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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-17-propanoic acid
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Accession:CHEBI:60779 term browser browse the term
Definition:The 2(1),2(2),13-trimethyl ester of (2S,2(1)R)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid.
Synonyms:related_synonym: (4R,4aS)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid 13-methyl ester;   3-[(1Z,6Z,12Z,17Z,23R,24S)-14-ethenyl-22,23-bis(methoxycarbonyl)-9-(3-methoxy-3-oxopropyl)-4,10,15,24-tetramethyl-25,26,27,28-tetraazahexacyclo[16.6.1.1(3,6).1(8,11).1(13,16).0(19,24)]octacosa-1,3(28),4,6,8,10,12,14,16(26),17,19,21-dodecaen-5-yl]propanoic acid;   Formula=C41H42N4O8;   InChI=1S/C41H42N4O8/c1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)24(11-14-36(46)47)32(44-30)18-33-25(12-15-37(48)51-6)21(3)28(43-33)16-31(23)42-29/h9-10,13,16-19,38,43,45H,1,11-12,14-15H2,2-8H3,(H,46,47)/b31-16-,32-18-,34-17-,35-19-/t38-,41+/m1/s1;   InChIKey=MNCZEEFHIBYYSK-SFOJKEPJSA-N;   SMILES=COC(=O)CCc1c(C)c2cc3nc(cc4[nH]c(cc5nc(cc1[nH]2)c(CCC(O)=O)c5C)[C@@]1(C)[C@@H](C(=O)OC)C(=CC=C41)C(=O)OC)c(C)c3C=C
 cyclic_relationship: is_enantiomer_of CHEBI:60778


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verteporfin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]] CTD PMID:35093381 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Amotl1 angiomotin-like 1 multiple interactions
decreases response to substance		 ISO Verteporfin inhibits the reaction [AMOTL1 protein results in increased activity of YAP1 protein]
Verteporfin results in decreased susceptibility to AMOTL1 protein		 CTD PMID:34480788 NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 multiple interactions
decreases expression		 ISO verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]
verteporfin results in decreased expression of ANKRD1 mRNA
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANKRD1 mRNA]		 CTD PMID:29725256 PMID:29893953 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]] CTD PMID:35093381 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]] CTD PMID:35093381 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BIRC5 mRNA] CTD PMID:29893953 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]] CTD PMID:35093381 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein] CTD PMID:31812773 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL5 protein] CTD PMID:31812773 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
decreases expression		 ISO Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]
Verteporfin results in decreased expression of CCN1 mRNA
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCN1 mRNA]		 CTD PMID:29725256 PMID:29893953 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions		 ISO Verteporfin results in decreased expression of CCN2 mRNA
Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
Verteporfin inhibits the reaction [[XMU-MP-1 co-treated with Cadmium Chloride] results in increased expression of CCN2 mRNA]		 CTD PMID:29725256 PMID:35027733 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNA2 mRNA] CTD PMID:29893953 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNB1 mRNA] CTD PMID:29893953 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cma1 chymase 1 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CMA1 protein] CTD PMID:31812773 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CSF3 protein] CTD PMID:31812773 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA] CTD PMID:29893953 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2C55 mRNA] CTD PMID:29893953 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238 		JBrowse link
G Fundc1 FUN14 domain containing 1 multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]] CTD PMID:35093381 NCBI chr  X:5,083,635...5,100,293
Ensembl chr  X:5,083,617...5,100,284 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]] CTD PMID:35093381 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO verteporfin results in increased expression of HMOX1 protein CTD PMID:16462769 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]		 CTD PMID:31812773 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak1 Janus kinase 1 multiple interactions
decreases expression		 ISO [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK1 protein
Verteporfin results in decreased expression of JAK1 protein		 CTD PMID:31812773 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 decreases expression
multiple interactions		 ISO Verteporfin results in decreased expression of JAK2 protein
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK2 protein		 CTD PMID:31812773 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions ISO Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM2 mRNA] CTD PMID:29893953 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO Verteporfin inhibits the reaction [perfluorooctanoic acid results in increased expression of MKI67 protein] CTD PMID:36152675 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT1 mRNA] CTD PMID:35027733 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA] CTD PMID:35027733 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]] CTD PMID:35093381 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]] CTD PMID:35093381 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Verteporfin results in increased cleavage of PARP1 protein CTD PMID:31494105 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rasal2 RAS protein activator like 2 multiple interactions ISO Verteporfin inhibits the reaction [RASAL2 protein results in increased activity of YAP1 protein] CTD PMID:34826200 NCBI chr13:69,279,882...69,569,161
Ensembl chr13:69,258,622...69,569,940 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of RELA protein; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased phosphorylation of RELA protein] CTD PMID:31812773 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression
multiple interactions		 ISO Verteporfin results in decreased expression of STAT1 protein
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT1 protein]		 CTD PMID:31812773 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression		 ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT3 protein]
Verteporfin results in decreased expression of STAT3 protein		 CTD PMID:31812773 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tead1 TEA domain transcription factor 1 multiple interactions ISO Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein] CTD PMID:29893953 NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
[EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]		 CTD PMID:31812773 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
decreases expression
decreases activity		 ISO
EXP		 Verteporfin inhibits the reaction [AMOTL1 protein results in increased activity of YAP1 protein]; Verteporfin inhibits the reaction [RASAL2 protein results in increased activity of YAP1 protein]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]
Verteporfin results in decreased expression of YAP1 protein
Verteporfin results in decreased activity of YAP1 protein
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased phosphorylation of YAP1 protein]]		 CTD PMID:29725256 PMID:29893953 PMID:31494105 PMID:34351699 PMID:34480788 More... NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        fuel 11355
          methanol 3971
            methyl ester 3917
              (2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-17-propanoic acid 37
                verteporfin 37
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organonitrogen heterocyclic compound 18148
                                    polypyrrole 698
                                      tetrapyrrole 585
                                        cyclic tetrapyrrole 456
                                          porphyrins 372
                                            beta-substituted porphyrin 37
                                              (2S,2(1)R)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid 37
                                                (2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-17-propanoic acid 37
                                                  verteporfin 37
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