CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: (2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid
Accession: CHEBI:60776
browse the term
Definition: The 2(1),2(2),17-trimethyl ester of (2S,2(1)R)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid.
Synonyms: related_synonym: (4R,4aS)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid 9-methyl ester; 3-[(1Z,6Z,12Z,17Z,23R,24S)-14-ethenyl-22,23-bis(methoxycarbonyl)-5-(3-methoxy-3-oxopropyl)-4,10,15,24-tetramethyl-25,26,27,28-tetraazahexacyclo[16.6.1.1(3,6).1(8,11).113,16.019,24]octacosa-1,3(28),4,6,8,10,12,14,16(26),17,19,21-dodecaen-9-yl]propanoic acid; Formula=C41H42N4O8; InChI=1S/C41H42N4O8/c1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)25(12-15-37(48)51-6)33(44-30)18-32-24(11-14-36(46)47)21(3)28(43-32)16-31(23)42-29/h9-10,13,16-19,38,43,45H,1,11-12,14-15H2,2-8H3,(H,46,47)/b31-16-,33-18-,34-17-,35-19-/t38-,41+/m1/s1; InChIKey=ZCQHFRFEJXRZDF-BMADBYGRSA-N; SMILES=COC(=O)CCc1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(O)=O)c5C)c(C=C)c4C)C1=CC=C([C@H](C(=O)OC)[C@]31C)C(=O)OC
cyclic_relationship: is_enantiomer_of CHEBI:60775
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Acsl4
acyl-CoA synthetase long-chain family member 4
multiple interactions
EXP
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]]
CTD
PMID:35093381
NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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Amotl1
angiomotin-like 1
multiple interactions decreases response to substance
ISO
Verteporfin inhibits the reaction [AMOTL1 protein results in increased activity of YAP1 protein] Verteporfin results in decreased susceptibility to AMOTL1 protein
CTD
PMID:34480788
NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573
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Ankrd1
ankyrin repeat domain 1
multiple interactions decreases expression
ISO
verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA] verteporfin results in decreased expression of ANKRD1 mRNA Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANKRD1 mRNA]
CTD
PMID:29725256 PMID:29893953
NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
CTD
PMID:35093381
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
CTD
PMID:35093381
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Birc5
baculoviral IAP repeat-containing 5
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BIRC5 mRNA]
CTD
PMID:29893953
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Casp9
caspase 9
multiple interactions
EXP
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]
CTD
PMID:35093381
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein]
CTD
PMID:31812773
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL5 protein]
CTD
PMID:31812773
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccn1
cellular communication network factor 1
multiple interactions decreases expression
ISO
Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA] Verteporfin results in decreased expression of CCN1 mRNA Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCN1 mRNA]
CTD
PMID:29725256 PMID:29893953
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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Ccn2
cellular communication network factor 2
decreases expression multiple interactions
ISO
Verteporfin results in decreased expression of CCN2 mRNA Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA] Verteporfin inhibits the reaction [[XMU-MP-1 co-treated with Cadmium Chloride] results in increased expression of CCN2 mRNA]
CTD
PMID:29725256 PMID:35027733
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Ccna2
cyclin A2
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNA2 mRNA]
CTD
PMID:29893953
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNB1 mRNA]
CTD
PMID:29893953
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cma1
chymase 1
multiple interactions
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CMA1 protein]
CTD
PMID:31812773
NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
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Csf3
colony stimulating factor 3
multiple interactions
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CSF3 protein]
CTD
PMID:31812773
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA]
CTD
PMID:29893953
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2C55 mRNA]
CTD
PMID:29893953
NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
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Fundc1
FUN14 domain containing 1
multiple interactions
EXP
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]]
CTD
PMID:35093381
NCBI chr X:5,083,635...5,100,293
Ensembl chr X:5,083,617...5,100,284
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Gpx4
glutathione peroxidase 4
multiple interactions
EXP
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]]
CTD
PMID:35093381
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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Hmox1
heme oxygenase 1
increases expression
ISO
verteporfin results in increased expression of HMOX1 protein
CTD
PMID:16462769
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il6
interleukin 6
multiple interactions
ISO
[EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
CTD
PMID:31812773
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Jak1
Janus kinase 1
multiple interactions decreases expression
ISO
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK1 protein Verteporfin results in decreased expression of JAK1 protein
CTD
PMID:31812773
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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Jak2
Janus kinase 2
decreases expression multiple interactions
ISO
Verteporfin results in decreased expression of JAK2 protein [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK2 protein
CTD
PMID:31812773
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Mcm2
minichromosome maintenance complex component 2
multiple interactions
ISO
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM2 mRNA]
CTD
PMID:29893953
NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
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Mki67
marker of proliferation Ki-67
multiple interactions
ISO
Verteporfin inhibits the reaction [perfluorooctanoic acid results in increased expression of MKI67 protein]
CTD
PMID:36152675
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mt1
metallothionein 1
multiple interactions
ISO
[Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]
CTD
PMID:35027733
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mt2A
metallothionein 2A
multiple interactions
ISO
[Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA]
CTD
PMID:35027733
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Nppb
natriuretic peptide B
multiple interactions
EXP
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]]
CTD
PMID:35093381
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Opa1
OPA1, mitochondrial dynamin like GTPase
multiple interactions
EXP
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]
CTD
PMID:35093381
NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
Verteporfin results in increased cleavage of PARP1 protein
CTD
PMID:31494105
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Rasal2
RAS protein activator like 2
multiple interactions
ISO
Verteporfin inhibits the reaction [RASAL2 protein results in increased activity of YAP1 protein]
CTD
PMID:34826200
NCBI chr13:69,279,882...69,569,161
Ensembl chr13:69,258,622...69,569,940
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of RELA protein; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased phosphorylation of RELA protein]
CTD
PMID:31812773
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Stat1
signal transducer and activator of transcription 1
decreases expression multiple interactions
ISO
Verteporfin results in decreased expression of STAT1 protein Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT1 protein]
CTD
PMID:31812773
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
multiple interactions decreases expression
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT3 protein] Verteporfin results in decreased expression of STAT3 protein
CTD
PMID:31812773
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tead1
TEA domain transcription factor 1
multiple interactions
ISO
Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]
CTD
PMID:29893953
NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369
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Tnf
tumor necrosis factor
multiple interactions
ISO
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] [EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
CTD
PMID:31812773
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Yap1
Yes1 associated transcriptional regulator
multiple interactions decreases expression decreases activity
ISO EXP
Verteporfin inhibits the reaction [AMOTL1 protein results in increased activity of YAP1 protein]; Verteporfin inhibits the reaction [RASAL2 protein results in increased activity of YAP1 protein]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA] Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein] Verteporfin results in decreased expression of YAP1 protein Verteporfin results in decreased activity of YAP1 protein Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased phosphorylation of YAP1 protein]]
CTD
PMID:29725256 PMID:29893953 PMID:31494105 PMID:34351699 PMID:34480788 PMID:34826200 PMID:35093381 More...
NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19874
role
19844
application
19689
fuel
11355
methanol
3971
methyl ester
3917
(2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid
37
verteporfin
37
Path 2
CHEBI ontology
19874
subatomic particle
19872
composite particle
19872
hadron
19872
baryon
19872
nucleon
19872
atomic nucleus
19872
atom
19872
main group element atom
19811
p-block element atom
19811
carbon group element atom
19751
carbon atom
19748
organic molecular entity
19748
organic molecule
19700
organic cyclic compound
19490
organic heterocyclic compound
18868
organonitrogen heterocyclic compound
18148
polypyrrole
698
tetrapyrrole
585
cyclic tetrapyrrole
456
porphyrins
372
beta-substituted porphyrin
37
(2S,2(1)R)-2(1),2(2)-dicarboxy-8-ethenyl-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13,17-dipropanoic acid
37
(2S,2(1)R)-8-ethenyl-2(1),2(2)-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,2(1)-dihydrobenzo[b]porphyrin-13-propanoic acid
37
verteporfin
37