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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:floxuridine
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Accession:CHEBI:60761 term browser browse the term
Definition:A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Synonyms:related_synonym: 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil;   1-beta-D-2'-Deoxyribofuranosyl-5-flurouracil;   1beta-D-2'-Deoxyribofuranosyl-5-flurouracil;   2'-Deoxy-5-fluorouridine;   5-Fluoro-2-desoxyuridine;   5-Fluorodeoxyuridine;   5-Fluorouracil 2'-deoxyriboside;   5-Fluorouracil deoxyriboside;   5-fluoro-2'-deoxyuridine;   5FDU;   Deoxyfluorouridine;   FdU;   Floxuridin;   Fluorodeoxyuridine;   Fluoruridine deoxyribose;   Formula=C9H11FN2O5;   InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1;   InChIKey=ODKNJVUHOIMIIZ-RRKCRQDMSA-N;   SMILES=OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O;   beta-5-Fluoro-2'-deoxyuridine;   floxiridina;   floxuridinum
 xref: CAS:50-91-9;   DrugBank:DB00322;   Drug_Central:1184;   HMDB:HMDB0014467;   KEGG:C11736;   KEGG:D04197;   LINCS:LSM-5588
 xref_mesh: MESH:D005467
 xref: PMID:12520460;   PMID:19744858;   PMID:19917528;   PMID:20218622;   PMID:20363130;   PMID:20391188;   PMID:28166217;   PMID:29438107;   PMID:3950402;   Reaxys:90221;   Wikipedia:Floxuridine


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floxuridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance
decreases response to substance		 ISO APEX1 protein mutant form results in increased susceptibility to Floxuridine
APEX1 protein results in decreased susceptibility to Floxuridine		 CTD PMID:19470598 PMID:22194930 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Atr ATR serine/threonine kinase decreases response to substance ISO ATR protein results in decreased susceptibility to Floxuridine CTD PMID:21613406 PMID:22194930 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G C1qbp complement C1q binding protein decreases response to substance ISO C1QBP protein results in decreased susceptibility to Floxuridine CTD PMID:25354864 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO Floxuridine results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21613406 PMID:22194930 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases activity		 ISO Floxuridine results in increased phosphorylation of and results in increased activity of CHEK2 protein
Floxuridine results in increased activity of CHEK2 protein		 CTD PMID:21613406 PMID:22194930 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Mlh1 mutL homolog 1 multiple interactions
decreases response to substance		 ISO olaparib inhibits the reaction [MLH1 protein results in decreased susceptibility to Floxuridine] CTD PMID:22194930 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 multiple interactions
decreases response to substance		 ISO olaparib inhibits the reaction [MSH2 protein results in decreased susceptibility to Floxuridine] CTD PMID:22194930 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR protein affects the susceptibility to Floxuridine CTD PMID:18202788 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases response to substance ISO PARP1 protein results in decreased susceptibility to Floxuridine CTD PMID:21613406 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects response to substance
decreases response to substance		 ISO TIMP3 protein affects the susceptibility to Floxuridine
TIMP3 gene modified form results in decreased susceptibility to Floxuridine		 CTD PMID:18202788 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO Floxuridine results in increased expression of TK1 protein CTD PMID:16951200 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Tp53 tumor protein p53 increases expression
affects activity		 ISO Floxuridine results in increased expression of TP53 protein
Floxuridine affects the activity of TP53 protein		 CTD PMID:19015155 PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tyms thymidylate synthetase affects response to substance
decreases response to substance
increases response to substance		 ISO TYMS protein affects the susceptibility to Floxuridine
TYMS protein results in decreased susceptibility to Floxuridine
TYMS results in increased susceptibility to Floxuridine		 CTD PMID:2537495 PMID:10482907 PMID:15040806 PMID:17018589 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Ung uracil-DNA glycosylase affects expression
affects stability
increases response to substance		 ISO Floxuridine affects the expression of UNG mRNA; Floxuridine affects the expression of UNG protein
Floxuridine affects the stability of UNG protein alternative form
UNG protein results in increased susceptibility to Floxuridine		 CTD PMID:16951200 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases response to substance ISO XRCC1 protein results in decreased susceptibility to Floxuridine CTD PMID:21613406 PMID:22194930 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance ISO XRCC4 results in decreased susceptibility to Floxuridine CTD PMID:21785230 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          antimetabolite 10285
            floxuridine 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbohydrates and carbohydrate derivatives 15289
                                    carbohydrate 15289
                                      carbohydrate derivative 14305
                                        glycosyl compound 13067
                                          N-glycosyl compound 5873
                                            nucleoside 5731
                                              deoxyribonucleoside 2889
                                                2'-deoxyribonucleoside 2246
                                                  pyrimidine 2'-deoxyribonucleoside 353
                                                    floxuridine 16
paths to the root