CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | bridged diphenyl antifungal agent |
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Accession: | CHEBI:60644
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browse the term
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Definition: | Any organic aromatic compound containing two phenyl (or substituted phenyl) groups attached to a single carbon or heteroatom and which has significant antifungal properties. |
Synonyms: | related_synonym: | bridged diphenyl antifungal agents |
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Ar |
androgen receptor |
multiple interactions |
ISO |
4'-hydroxydiclofenac binds to and affects the activity of AR protein |
CTD |
PMID:29777833 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
4'-hydroxydiclofenac results in increased expression of CCL2 mRNA |
CTD |
PMID:24104198 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Esr1 |
estrogen receptor 1 |
affects activity |
ISO |
4'-hydroxydiclofenac affects the activity of ESR1 protein |
CTD |
PMID:29777833 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Gstp1 |
glutathione S-transferase pi 1 |
increases glutathionylation multiple interactions |
ISO |
GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] |
CTD |
PMID:24246759 PMID:24552538 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Il10 |
interleukin 10 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein] |
CTD |
PMID:29777833 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il2 |
interleukin 2 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] |
CTD |
PMID:29777833 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il4 |
interleukin 4 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein] |
CTD |
PMID:29777833 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6 |
interleukin 6 |
multiple interactions |
ISO |
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein] |
CTD |
PMID:29777833 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mpo |
myeloperoxidase |
multiple interactions |
ISO |
4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac |
CTD |
PMID:28754375 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac] |
CTD |
PMID:24552538 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nqo2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
multiple interactions |
ISO |
NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac |
CTD |
PMID:29281794 |
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NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein |
CTD |
PMID:29777833 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Tnf |
tumor necrosis factor |
increases response to substance multiple interactions |
EXP ISO |
TNF protein results in increased susceptibility to 4'-hydroxydiclofenac 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein] |
CTD |
PMID:23939143 PMID:29777833 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
[CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
ISO |
[CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions |
ISO |
[CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] |
CTD |
PMID:24246759 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
ISO |
[CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac |
CTD |
PMID:24246759 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] |
CTD |
PMID:24246759 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 5-hydroxydiclofenac |
CTD |
PMID:28754375 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Adam17 |
ADAM metallopeptidase domain 17 |
increases response to substance |
ISO |
ADAM17 results in increased susceptibility to aceclofenac |
CTD |
PMID:12147693 |
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NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
aceclofenac results in increased expression of GDF15 protein aceclofenac results in increased expression of GDF15 mRNA |
CTD |
PMID:15555568 PMID:18076062 |
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NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Sell |
selectin L |
decreases expression |
ISO |
aceclofenac results in decreased expression of SELL protein |
CTD |
PMID:12147693 |
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NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
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Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein |
CTD |
PMID:17328244 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Iyd |
iodotyrosine deiodinase |
multiple interactions |
ISO |
Bithionol inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] |
CTD |
PMID:33352258 |
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NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Bithionol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Thra |
thyroid hormone receptor alpha |
increases activity |
EXP |
Bithionol results in increased activity of THRA protein |
CTD |
PMID:22015988 |
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NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Thrb |
thyroid hormone receptor beta |
increases activity |
EXP |
Bithionol results in increased activity of THRB protein |
CTD |
PMID:22015988 |
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NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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Tp53 |
tumor protein p53 |
affects activity |
ISO |
Bithionol affects the activity of TP53 protein |
CTD |
PMID:35435491 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Iyd |
iodotyrosine deiodinase |
multiple interactions |
ISO |
Dichlorophen inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] |
CTD |
PMID:33352258 |
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NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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Tp53 |
tumor protein p53 |
affects activity |
ISO |
Dichlorophen affects the activity of TP53 protein |
CTD |
PMID:35435491 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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A2m |
alpha-2-macroglobulin |
increases expression |
ISO |
Diclofenac results in increased expression of A2M mRNA; Diclofenac results in increased expression of A2ML1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Aacs |
acetoacetyl-CoA synthetase |
decreases expression |
ISO |
Diclofenac results in decreased expression of AACS mRNA |
CTD |
PMID:26934552 |
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NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954
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Aars1 |
alanyl-tRNA synthetase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of AARS1 mRNA |
CTD |
PMID:35537566 |
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NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
Diclofenac inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Diclofenac results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 PMID:28437613 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression decreases response to substance decreases activity |
ISO |
Diclofenac results in increased expression of ABCB1B mRNA ABCB1A gene mutant form results in decreased susceptibility to Diclofenac Diclofenac results in decreased activity of ABCB1A protein |
CTD |
PMID:15458769 PMID:19022234 PMID:28193520 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b |
ATP-binding cassette, sub-family B member 1B |
decreases expression |
EXP |
Diclofenac results in decreased expression of ABCB1B mRNA |
CTD |
PMID:19022234 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases expression decreases activity |
ISO |
Diclofenac results in decreased expression of ABCB4 mRNA Diclofenac results in decreased activity of ABCB4 protein |
CTD |
PMID:19022234 PMID:28437613 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases activity increases expression multiple interactions |
ISO EXP |
Diclofenac results in decreased activity of ABCC2 protein Diclofenac results in increased expression of ABCC2 mRNA ABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to Diclofenac |
CTD |
PMID:19022234 PMID:22646477 PMID:25450747 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc4 |
ATP binding cassette subfamily C member 4 |
affects expression |
ISO |
Diclofenac affects the expression of ABCC4 mRNA |
CTD |
PMID:24752500 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Abl2 |
ABL proto-oncogene 2, non-receptor tyrosine kinase |
affects expression |
ISO |
Diclofenac affects the expression of ABL2 mRNA |
CTD |
PMID:24752500 |
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NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742
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G |
Ace2 |
angiotensin converting enzyme 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Acin1 |
apoptotic chromatin condensation inducer 1 |
affects expression |
ISO |
Diclofenac affects the expression of ACIN1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001
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G |
Ackr3 |
atypical chemokine receptor 3 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ACKR3 mRNA |
CTD |
PMID:19192274 |
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NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
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Acot2 |
acyl-CoA thioesterase 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ACOT2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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Acox1 |
acyl-CoA oxidase 1 |
increases expression |
EXP |
Diclofenac results in increased expression of ACOX1 mRNA |
CTD |
PMID:19022234 |
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NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Acp3 |
acid phosphatase 3 |
increases expression |
ISO |
Diclofenac results in increased expression of ACP3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236
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Acta1 |
actin, alpha 1, skeletal muscle |
affects expression |
ISO |
Diclofenac affects the expression of ACTA1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
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Actl9 |
actin-like 9 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of ACTL9 mRNA |
CTD |
PMID:37844793 |
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NCBI chr 7:14,234,504...14,235,881
Ensembl chr 7:14,234,504...14,235,881
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G |
Actn1 |
actinin, alpha 1 |
affects expression |
EXP |
Diclofenac affects the expression of ACTN1 mRNA |
CTD |
PMID:19022234 |
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NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
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Acvr1 |
activin A receptor type 1 |
affects expression |
ISO |
Diclofenac affects the expression of ACVR1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
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Acvr1b |
activin A receptor type 1B |
affects expression multiple interactions |
ISO |
Diclofenac affects the expression of ACVR1B mRNA [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ACVR1B mRNA |
CTD |
PMID:24752500 PMID:37844793 |
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NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673
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Acvr2b |
activin A receptor type 2B |
affects expression |
ISO |
Diclofenac affects the expression of ACVR2B mRNA |
CTD |
PMID:24752500 |
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NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
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G |
Adamdec1 |
ADAM-like, decysin 1 |
increases expression |
ISO |
Diclofenac results in increased expression of ADAMDEC1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr15:42,900,629...42,921,684
Ensembl chr15:42,900,636...42,921,712
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G |
Adcy6 |
adenylate cyclase 6 |
affects expression |
ISO |
Diclofenac affects the expression of ADCY6 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
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G |
Adcy9 |
adenylate cyclase 9 |
affects expression decreases expression |
ISO |
Diclofenac affects the expression of ADCY9 mRNA Diclofenac results in decreased expression of ADCY9 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
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NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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G |
Adh1c |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
increases expression |
EXP |
Diclofenac results in increased expression of ADH1 protein |
CTD |
PMID:25772430 |
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NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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G |
Adh7 |
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
decreases expression |
ISO |
Diclofenac results in decreased expression of ADH7 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
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G |
Adk |
adenosine kinase |
increases expression decreases expression |
ISO EXP |
Diclofenac results in increased expression of ADK mRNA Diclofenac results in decreased expression of ADK mRNA |
CTD |
PMID:19022234 |
|
NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
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G |
Adora2a |
adenosine A2a receptor |
increases expression |
ISO |
Diclofenac results in increased expression of ADORA2A mRNA |
CTD |
PMID:26934552 |
|
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Adora2b |
adenosine A2B receptor |
increases expression |
ISO |
Diclofenac results in increased expression of ADORA2B mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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G |
Adrb2 |
adrenoceptor beta 2 |
increases expression |
ISO |
Diclofenac results in increased expression of ADRB2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Aen |
apoptosis enhancing nuclease |
increases expression |
ISO |
Diclofenac results in increased expression of AEN mRNA |
CTD |
PMID:35537566 |
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NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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G |
Ager |
advanced glycosylation end product-specific receptor |
increases expression |
ISO |
Diclofenac results in increased expression of AGER mRNA |
CTD |
PMID:24747151 PMID:28138970 |
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NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Aggf1 |
angiogenic factor with G patch and FHA domains 1 |
affects expression |
ISO |
Diclofenac affects the expression of AGGF1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:26,619,336...26,646,050
Ensembl chr 2:26,619,339...26,645,952
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G |
Ago2 |
argonaute RISC catalytic component 2 |
affects expression |
ISO |
Diclofenac affects the expression of AGO2 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974
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G |
Ago3 |
argonaute RISC catalytic component 3 |
affects expression |
ISO |
Diclofenac affects the expression of AGO3 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
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G |
Ago4 |
argonaute RISC component 4 |
affects expression |
ISO |
Diclofenac affects the expression of AGO4 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:138,780,446...138,825,898
Ensembl chr 5:138,783,069...138,825,632
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G |
Agrp |
agouti related neuropeptide |
increases expression |
EXP |
Diclofenac results in increased expression of AGRP mRNA |
CTD |
PMID:30723492 |
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NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
Diclofenac results in increased expression of AHR mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ahsg |
alpha-2-HS-glycoprotein |
multiple interactions |
EXP |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein |
CTD |
PMID:25772430 |
|
NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
affects expression |
ISO |
Diclofenac affects the expression of AIFM1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Aim2 |
absent in melanoma 2 |
increases expression |
ISO |
Diclofenac results in increased expression of AIM2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975
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G |
Akna |
AT-hook transcription factor |
decreases expression |
ISO |
Diclofenac results in decreased expression of AKNA mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
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G |
Akr1b7 |
aldo-keto reductase family 1, member B7 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AKR1B7 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
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G |
Akt1 |
AKT serine/threonine kinase 1 |
affects expression |
ISO |
Diclofenac affects the expression of AKT1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
affects expression |
ISO |
Diclofenac affects the expression of AKT2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Alas1 |
5'-aminolevulinate synthase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ALAS1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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G |
Alas2 |
5'-aminolevulinate synthase 2 |
affects expression |
ISO |
Diclofenac affects the expression of ALAS2 mRNA |
CTD |
PMID:24752500 |
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NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
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G |
Alb |
albumin |
affects binding decreases secretion multiple interactions decreases expression increases expression |
ISO EXP |
Diclofenac binds to ALB protein Diclofenac results in decreased secretion of ALB protein [Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein] Diclofenac results in decreased expression of ALB protein Diclofenac results in increased expression of ALB mRNA |
CTD |
PMID:9353694 PMID:19022234 PMID:28400101 PMID:36442613 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh18a1 |
aldehyde dehydrogenase 18 family, member A1 |
increases expression decreases expression |
ISO |
Diclofenac results in increased expression of ALDH18A1 mRNA Diclofenac results in decreased expression of ALDH18A1 mRNA |
CTD |
PMID:26934552 PMID:35537566 |
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NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890
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G |
Aldh1b1 |
aldehyde dehydrogenase 1 family, member B1 |
increases expression |
ISO |
Diclofenac results in increased expression of ALDH1B1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
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G |
Aldh1l2 |
aldehyde dehydrogenase 1 family, member L2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ALDH1L2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776
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G |
Aldh3a2 |
aldehyde dehydrogenase 3 family, member A2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ALDH3A2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
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G |
Aldoc |
aldolase, fructose-bisphosphate C |
increases expression |
EXP |
Diclofenac results in increased expression of ALDOC mRNA |
CTD |
PMID:30723492 |
|
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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G |
Alox15 |
arachidonate 15-lipoxygenase |
increases expression multiple interactions |
EXP ISO |
Diclofenac results in increased expression of ALOX15 mRNA [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ALOX15 mRNA |
CTD |
PMID:23939143 PMID:37844793 |
|
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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G |
Amh |
anti-Mullerian hormone |
increases expression multiple interactions |
ISO |
Diclofenac results in increased expression of AMH mRNA [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AMH mRNA |
CTD |
PMID:35537566 PMID:37844793 |
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NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
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G |
Amotl2 |
angiomotin like 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of AMOTL2 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910
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G |
Ang |
angiogenin |
increases expression |
ISO |
Diclofenac results in increased expression of ANG mRNA |
CTD |
PMID:26934552 |
|
NCBI chr15:24,312,711...24,323,361
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G |
Anxa8 |
annexin A8 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ANXA8 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043
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G |
Aoc3 |
amine oxidase, copper containing 3 |
decreases expression |
ISO |
Diclofenac results in decreased expression of AOC3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:86,272,757...86,280,702
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
affects expression |
ISO |
Diclofenac affects the expression of APAF1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apcs |
amyloid P component, serum |
multiple interactions increases expression |
EXP ISO |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein Diclofenac results in increased expression of APCS mRNA; Diclofenac results in increased expression of APCS protein |
CTD |
PMID:25772430 PMID:26934552 |
|
NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298
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G |
Apoa4 |
apolipoprotein A4 |
affects expression |
ISO |
Diclofenac affects the expression of APOA4 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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G |
Aqp2 |
aquaporin 2 |
decreases expression |
EXP |
Diclofenac results in decreased expression of AQP2 protein |
CTD |
PMID:15579502 |
|
NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
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G |
Aqp9 |
aquaporin 9 |
decreases expression |
ISO |
Diclofenac results in decreased expression of AQP9 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G |
Aqr |
aquarius intron-binding spliceosomal factor |
affects expression |
ISO |
Diclofenac affects the expression of AQR mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044
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G |
Ar |
androgen receptor |
affects activity |
ISO |
Diclofenac affects the activity of AR protein |
CTD |
PMID:29777833 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Araf |
A-Raf proto-oncogene, serine/threonine kinase |
affects expression |
ISO |
Diclofenac affects the expression of ARAF mRNA |
CTD |
PMID:24752500 |
|
NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073
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G |
Arhgap20 |
Rho GTPase activating protein 20 |
increases expression |
EXP |
Diclofenac results in increased expression of ARHGAP20 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr 8:52,074,472...52,155,739
Ensembl chr 8:52,074,158...52,155,739
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G |
Arhgap26 |
Rho GTPase activating protein 26 |
affects expression |
ISO |
Diclofenac affects the expression of ARHGAP26 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr18:30,835,806...31,237,945
Ensembl chr18:30,838,671...31,235,194
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G |
Arhgef2 |
Rho/Rac guanine nucleotide exchange factor 2 |
affects expression |
ISO |
Diclofenac affects the expression of ARHGEF2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
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G |
Arhgef3 |
Rho guanine nucleotide exchange factor 3 |
affects expression decreases expression |
ISO |
Diclofenac affects the expression of ARHGEF3 mRNA Diclofenac results in decreased expression of ARHGEF3 mRNA |
CTD |
PMID:24752500 PMID:35537566 |
|
NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945
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G |
Arhgef7 |
Rho guanine nucleotide exchange factor 7 |
affects expression |
ISO |
Diclofenac affects the expression of ARHGEF7 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697
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G |
Arid4a |
AT-rich interaction domain 4A |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ARID4A mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 6:89,522,459...89,593,868
Ensembl chr 6:89,522,442...89,593,510
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G |
Arid5a |
AT-rich interaction domain 5A |
decreases expression |
ISO |
Diclofenac results in decreased expression of ARID5A mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597
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G |
Arid5b |
AT-rich interaction domain 5B |
decreases expression |
ISO |
Diclofenac results in decreased expression of ARID5B mRNA |
CTD |
PMID:26934552 |
|
NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433
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G |
Arl11 |
ADP-ribosylation factor like GTPase 11 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ARL11 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr15:35,483,330...35,485,579
Ensembl chr15:35,480,018...35,496,596
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G |
Armcx1 |
armadillo repeat containing, X-linked 1 |
increases expression |
EXP |
Diclofenac results in increased expression of ARMCX1 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299
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|
G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
affects expression |
ISO |
Diclofenac affects the expression of ARNT mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Arrb1 |
arrestin, beta 1 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ARRB1 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
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G |
Arrdc3 |
arrestin domain containing 3 |
increases expression |
ISO |
Diclofenac results in increased expression of ARRDC3 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978
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G |
Asap1 |
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 |
affects expression |
ISO |
Diclofenac affects the expression of ASAP1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754
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|
G |
Ash2l |
ASH2 like histone lysine methyltransferase complex subunit |
affects expression |
ISO |
Diclofenac affects the expression of ASH2L mRNA |
CTD |
PMID:24752500 |
|
NCBI chr16:66,242,205...66,264,064
Ensembl chr16:66,242,212...66,264,061
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|
G |
Asic1 |
acid sensing ion channel subunit 1 |
decreases expression |
EXP |
Diclofenac results in decreased expression of ASIC1 mRNA |
CTD |
PMID:11588175 |
|
NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
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G |
Asic2 |
acid sensing ion channel subunit 2 |
decreases expression |
EXP |
Diclofenac results in decreased expression of ASIC2 mRNA |
CTD |
PMID:11588175 |
|
NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424
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G |
Asic3 |
acid sensing ion channel subunit 3 |
decreases expression decreases activity |
EXP |
Diclofenac results in decreased expression of ASIC3 mRNA Diclofenac results in decreased activity of ASIC3 protein |
CTD |
PMID:11588175 |
|
NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643
|
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G |
Asl |
argininosuccinate lyase |
affects expression |
ISO |
Diclofenac affects the expression of ASL mRNA |
CTD |
PMID:24752500 |
|
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
|
|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
decreases expression increases expression |
ISO |
Diclofenac results in decreased expression of ASNS mRNA Diclofenac results in increased expression of ASNS mRNA |
CTD |
PMID:19192274 PMID:26934552 PMID:35537566 |
|
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
|
|
G |
Ass1 |
argininosuccinate synthase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ASS1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
|
|
G |
Atf2 |
activating transcription factor 2 |
affects expression |
ISO |
Diclofenac affects the expression of ATF2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
|
|
G |
Atf4 |
activating transcription factor 4 |
affects expression decreases expression increases expression |
ISO |
Diclofenac affects the expression of ATF4 mRNA Diclofenac results in decreased expression of ATF4 mRNA Diclofenac results in increased expression of ATF4 mRNA |
CTD |
PMID:24752500 PMID:27313093 PMID:35537566 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
|
|
G |
Atf5 |
activating transcription factor 5 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ATF5 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
|
|
G |
Atp11a |
ATPase phospholipid transporting 11A |
increases expression |
ISO |
Diclofenac results in increased expression of ATP11A mRNA |
CTD |
PMID:26934552 |
|
NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
|
|
G |
Atp5f1a |
ATP synthase F1 subunit alpha |
multiple interactions increases expression |
EXP |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1A protein Diclofenac results in increased expression of ATP5F1A protein |
CTD |
PMID:25772430 |
|
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
|
|
G |
Atp5f1b |
ATP synthase F1 subunit beta |
multiple interactions increases expression |
EXP |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1B protein Diclofenac results in increased expression of ATP5F1B protein |
CTD |
PMID:25772430 |
|
NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
|
|
G |
Atp5pf |
ATP synthase peripheral stalk subunit F6 |
multiple interactions increases expression |
EXP |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5PF protein Diclofenac results in increased expression of ATP5PF protein |
CTD |
PMID:25772430 |
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NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
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G |
Azin1 |
antizyme inhibitor 1 |
affects expression |
ISO |
Diclofenac affects the expression of AZIN1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578
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G |
B3galt1 |
Beta-1,3-galactosyltransferase 1 |
increases expression |
ISO |
Diclofenac results in increased expression of B3GALT1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313
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G |
Bach1 |
BTB domain and CNC homolog 1 |
affects expression |
ISO |
Diclofenac affects the expression of BACH1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases activity |
ISO |
Diclofenac results in increased activity of BAK1 protein |
CTD |
PMID:18191430 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bard1 |
BRCA1 associated RING domain 1 |
affects expression |
ISO |
Diclofenac affects the expression of BARD1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases activity increases expression affects localization |
ISO EXP |
Diclofenac results in increased activity of BAX protein Diclofenac results in increased expression of BAX mRNA Diclofenac affects the localization of BAX protein |
CTD |
PMID:18191430 PMID:29027214 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcar3 |
BCAR3 adaptor protein, NSP family member |
decreases expression |
ISO |
Diclofenac results in decreased expression of BCAR3 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
ISO EXP |
Diclofenac results in increased expression of BCL2 mRNA |
CTD |
PMID:29027214 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2a1 |
BCL2-related protein A1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of BCL2A1 mRNA |
CTD |
PMID:19192274 |
|
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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G |
Bcl2l1 |
Bcl2-like 1 |
increases expression affects expression |
ISO |
Diclofenac results in increased expression of BCL2L1 mRNA alternative form Diclofenac affects the expression of BCL2L1 mRNA |
CTD |
PMID:14609740 PMID:24752500 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
affects expression |
ISO |
Diclofenac affects the expression of BCL2L11 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bcl3 |
BCL3, transcription coactivator |
increases expression |
ISO |
Diclofenac results in increased expression of BCL3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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G |
Bcl6 |
BCL6, transcription repressor |
decreases expression |
ISO |
Diclofenac results in decreased expression of BCL6 mRNA |
CTD |
PMID:26934552 |
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NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
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G |
Bdh1 |
3-hydroxybutyrate dehydrogenase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of BDH1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions affects expression increases activity |
ISO |
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Diclofenac results in increased activity of BID protein] Diclofenac affects the expression of BID mRNA |
CTD |
PMID:18191430 PMID:24752500 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Bmp4 |
bone morphogenetic protein 4 |
affects expression |
ISO |
Diclofenac affects the expression of BMP4 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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G |
Bmp6 |
bone morphogenetic protein 6 |
decreases expression increases expression |
ISO |
Diclofenac results in decreased expression of BMP6 mRNA Diclofenac results in increased expression of BMP6 mRNA |
CTD |
PMID:26934552 PMID:32816093 |
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NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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G |
Braf |
B-Raf proto-oncogene, serine/threonine kinase |
affects expression |
ISO |
Diclofenac affects the expression of BRAF mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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G |
Brca1 |
BRCA1, DNA repair associated |
increases expression |
ISO |
Diclofenac results in increased expression of BRCA1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Brca2 |
BRCA2, DNA repair associated |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of BRCA2 mRNA |
CTD |
PMID:37844793 |
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NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
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G |
Brd3os |
BRD3 opposite strand |
decreases expression |
ISO |
Diclofenac results in decreased expression of BRD3OS mRNA |
CTD |
PMID:35537566 |
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NCBI chr 3:10,770,229...10,771,860
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G |
Brdt |
bromodomain testis associated |
decreases expression |
ISO |
Diclofenac results in decreased expression of BRDT mRNA |
CTD |
PMID:35537566 |
|
NCBI chr14:2,387,372...2,445,857
Ensembl chr14:2,387,796...2,445,842
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G |
Brip1 |
BRCA1 interacting helicase 1 |
affects expression |
ISO |
Diclofenac affects the expression of BRIP1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
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G |
Btg1 |
BTG anti-proliferation factor 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of BTG1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
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G |
C1qa |
complement C1q A chain |
increases expression |
ISO |
Diclofenac results in increased expression of C1QA mRNA |
CTD |
PMID:26934552 |
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NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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G |
C1qb |
complement C1q B chain |
increases expression |
ISO |
Diclofenac results in increased expression of C1QB mRNA |
CTD |
PMID:26934552 |
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NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
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G |
C1qc |
complement C1q C chain |
increases expression |
ISO |
Diclofenac results in increased expression of C1QC mRNA |
CTD |
PMID:26934552 |
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NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
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G |
C2 |
complement C2 |
increases expression |
ISO |
Diclofenac results in increased expression of C2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505
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G |
C4b |
complement C4B |
increases expression |
ISO |
Diclofenac results in increased expression of C4B mRNA |
CTD |
PMID:26934552 |
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NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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G |
Cacna1b |
calcium voltage-gated channel subunit alpha1 B |
decreases expression |
ISO |
Diclofenac results in decreased expression of CACNA1B mRNA |
CTD |
PMID:26934552 |
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NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091
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G |
Calca |
calcitonin-related polypeptide alpha |
decreases expression |
EXP |
Diclofenac results in decreased expression of CALCA mRNA |
CTD |
PMID:11588175 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Calm1 |
calmodulin 1 |
affects expression |
ISO |
Diclofenac affects the expression of CALM1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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G |
Calml3 |
calmodulin-like 3 |
increases expression |
EXP |
Diclofenac results in increased expression of CALML3 mRNA |
CTD |
PMID:30723492 |
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NCBI chr17:66,419,844...66,423,083
Ensembl chr17:66,419,882...66,423,175
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G |
Calr |
calreticulin |
affects expression decreases expression |
EXP |
Diclofenac affects the expression of CALR mRNA Diclofenac results in decreased expression of CALR mRNA |
CTD |
PMID:18246545 |
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NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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G |
Camk1d |
calcium/calmodulin-dependent protein kinase ID |
increases expression |
ISO |
Diclofenac results in increased expression of CAMK1D mRNA |
CTD |
PMID:26934552 |
|
NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556
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G |
Camk2b |
calcium/calmodulin-dependent protein kinase II beta |
increases expression |
EXP |
Diclofenac results in increased expression of CAMK2B mRNA |
CTD |
PMID:30723492 |
|
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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G |
Camp |
cathelicidin antimicrobial peptide |
increases expression |
ISO |
Diclofenac results in increased expression of CAMP mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
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G |
Capn10 |
calpain 10 |
affects expression |
ISO |
Diclofenac affects the expression of CAPN10 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494
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G |
Car1 |
carbonic anhydrase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CAR1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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G |
Car13 |
carbonic anhydrase 13 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CAR13 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525
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G |
Car3 |
carbonic anhydrase 3 |
decreases expression increases secretion |
ISO EXP |
Diclofenac results in decreased expression of CAR3 mRNA Diclofenac results in increased secretion of CAR3 protein |
CTD |
PMID:24038040 PMID:26934552 |
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NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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G |
Cars1 |
cysteinyl-tRNA synthetase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CARS1 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
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G |
Casp1 |
caspase 1 |
multiple interactions increases cleavage |
EXP |
diacerein inhibits the reaction [Diclofenac results in increased cleavage of CASP1 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] |
CTD |
PMID:25450234 PMID:38582345 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp2 |
caspase 2 |
multiple interactions affects expression |
ISO |
Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP2 protein] Diclofenac affects the expression of CASP2 mRNA |
CTD |
PMID:16388830 PMID:24752500 |
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NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO EXP |
Diclofenac results in increased activity of CASP3 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein] 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein]; Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein] |
CTD |
PMID:12826271 PMID:14599462 PMID:14609740 PMID:16388830 PMID:24770551 PMID:26609140 PMID:27313093 PMID:31042592 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
affects expression |
ISO |
Diclofenac affects the expression of CASP6 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp8 |
caspase 8 |
increases activity affects expression multiple interactions |
EXP ISO |
Diclofenac results in increased activity of CASP8 protein Diclofenac affects the expression of CASP8 mRNA [Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein] |
CTD |
PMID:14609740 PMID:20237495 PMID:24752500 PMID:27313093 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression increases activity |
ISO EXP |
[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP9 protein] Diclofenac results in increased expression of CASP9 mRNA |
CTD |
PMID:14609740 PMID:16388830 PMID:25014874 PMID:27313093 PMID:29027214 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
increases activity decreases activity multiple interactions |
EXP ISO |
Diclofenac results in increased activity of CAT protein Diclofenac results in decreased activity of CAT protein Ondansetron promotes the reaction [Diclofenac results in decreased activity of CAT protein] [Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of CAT protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of CAT protein] |
CTD |
PMID:17274466 PMID:23994749 PMID:28535741 PMID:31042592 PMID:31332906 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cbl |
Cbl proto-oncogene |
affects expression |
ISO |
Diclofenac affects the expression of CBL mRNA |
CTD |
PMID:24752500 |
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NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
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G |
Cbr1 |
carbonyl reductase 1 |
affects expression |
ISO |
Diclofenac affects the expression of CBR1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Cbs |
cystathionine beta synthase |
affects expression |
ISO |
Diclofenac affects the expression of CBS mRNA |
CTD |
PMID:24752500 |
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NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
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G |
Ccdc137 |
coiled-coil domain containing 137 |
increases expression |
ISO |
Diclofenac results in increased expression of CCDC137 mRNA |
CTD |
PMID:35537566 |
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NCBI chr10:105,730,776...105,737,158
Ensembl chr10:105,730,739...105,737,158
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases secretion increases expression affects expression |
EXP ISO |
[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein] Diclofenac analog results in increased secretion of CCL2 protein SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA] Diclofenac results in increased expression of CCL2 protein Diclofenac affects the expression of CCL2 mRNA Diclofenac results in increased expression of CCL2 mRNA |
CTD |
PMID:22285467 PMID:23939143 PMID:24104198 PMID:25051504 PMID:27671914 PMID:31042592 More...
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions decreases expression |
EXP ISO |
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA] Diclofenac results in decreased expression of CCL3 mRNA |
CTD |
PMID:23939143 PMID:35537566 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccl9 |
C-C motif chemokine ligand 9 |
increases expression |
ISO |
Diclofenac results in increased expression of CCL6 mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
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G |
Ccn1 |
cellular communication network factor 1 |
affects expression increases expression |
ISO |
Diclofenac affects the expression of CCN1 mRNA Diclofenac results in increased expression of CCN1 mRNA |
CTD |
PMID:19192274 PMID:24752500 |
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NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G |
Ccnd1 |
cyclin D1 |
multiple interactions affects expression decreases expression increases expression |
ISO EXP |
Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein] Diclofenac affects the expression of CCND1 mRNA Diclofenac results in decreased expression of CCND1 mRNA Diclofenac results in increased expression of CCND1 mRNA Diclofenac results in decreased expression of CCND1 protein |
CTD |
PMID:15188006 PMID:15489888 PMID:19022234 PMID:26934552 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd3 |
cyclin D3 |
affects expression |
ISO |
Diclofenac affects the expression of CCND3 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
affects expression |
ISO |
Diclofenac affects the expression of CCNE1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccne2 |
cyclin E2 |
affects expression |
ISO |
Diclofenac affects the expression of CCNE2 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Ccnf |
cyclin F |
affects expression |
ISO |
Diclofenac affects the expression of CCNF mRNA |
CTD |
PMID:24752500 |
|
NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
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G |
Ccng1 |
cyclin G1 |
increases expression |
EXP |
Diclofenac results in increased expression of CCNG1 mRNA |
CTD |
PMID:19022234 |
|
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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G |
Ccnh |
cyclin H |
affects expression |
ISO |
Diclofenac affects the expression of CCNH mRNA |
CTD |
PMID:24752500 |
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NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819
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G |
Ccr1 |
C-C motif chemokine receptor 1 |
increases expression |
ISO |
Diclofenac results in increased expression of CCR1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 8:123,556,286...123,561,841
|
|
G |
Ccr5 |
C-C motif chemokine receptor 5 |
increases expression |
ISO |
Diclofenac results in increased expression of CCR5 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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|
G |
Cd14 |
CD14 molecule |
increases expression |
ISO |
Diclofenac results in increased expression of CD14 mRNA |
CTD |
PMID:26934552 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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|
G |
Cd163 |
CD163 molecule |
increases expression |
ISO |
Diclofenac results in increased expression of CD163 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
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|
G |
Cd200r1l |
CD200 receptor 1-like |
decreases expression |
ISO |
Diclofenac results in decreased expression of CD200R4 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr11:55,842,632...55,860,914
Ensembl chr11:55,842,634...55,885,680
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|
G |
Cd244 |
CD244 molecule |
decreases expression |
ISO |
Diclofenac results in decreased expression of CD244 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr13:84,051,339...84,082,864
Ensembl chr13:84,052,493...84,074,492
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|
G |
Cd28 |
Cd28 molecule |
increases expression |
ISO |
Diclofenac results in increased expression of CD28 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
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|
G |
Cd44 |
CD44 molecule |
increases expression |
ISO |
Diclofenac results in increased expression of CD44 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd55 |
CD55 molecule (Cromer blood group) |
increases expression |
ISO |
Diclofenac results in increased expression of CD55 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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G |
Cd5l |
Cd5 molecule-like |
increases expression |
ISO |
Diclofenac results in increased expression of CD5L mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
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|
G |
Cd9 |
CD9 molecule |
increases expression |
ISO |
Diclofenac results in increased expression of CD9 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
|
|
G |
Cdc42ep5 |
CDC42 effector protein 5 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CDC42EP5 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 1:70,035,921...70,038,990
|
|
G |
Cdc6 |
cell division cycle 6 |
affects expression |
ISO |
Diclofenac affects the expression of CDC6 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
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G |
Cdc7 |
cell division cycle 7 |
affects expression |
ISO |
Diclofenac affects the expression of CDC7 mRNA |
CTD |
PMID:24752500 |
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NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
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G |
Cdca5 |
cell division cycle associated 5 |
increases expression |
ISO |
Diclofenac results in increased expression of CDCA5 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023
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G |
Cdh1 |
cadherin 1 |
increases expression affects expression decreases expression |
ISO EXP |
Diclofenac results in increased expression of CDH1 protein Diclofenac affects the expression of CDH1 mRNA Diclofenac results in decreased expression of CDH1 mRNA |
CTD |
PMID:19022234 PMID:19628293 PMID:24752500 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdk2 |
cyclin dependent kinase 2 |
affects expression |
ISO |
Diclofenac affects the expression of CDK2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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|
G |
Cdk5 |
cyclin-dependent kinase 5 |
affects expression |
ISO |
Diclofenac affects the expression of CDK5 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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G |
Cdk5r1 |
cyclin-dependent kinase 5 regulatory subunit 1 |
increases expression |
EXP |
Diclofenac results in increased expression of CDK5R1 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
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G |
Cdk6 |
cyclin-dependent kinase 6 |
affects expression |
ISO |
Diclofenac affects the expression of CDK6 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdk7 |
cyclin-dependent kinase 7 |
affects expression |
ISO |
Diclofenac affects the expression of CDK7 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO EXP |
Diclofenac results in increased expression of CDKN1A mRNA |
CTD |
PMID:19022234 PMID:26934552 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
affects expression |
ISO |
Diclofenac affects the expression of CDKN1B mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdt1 |
chromatin licensing and DNA replication factor 1 |
affects expression |
ISO |
Diclofenac affects the expression of CDT1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659
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|
G |
Cebpb |
CCAAT/enhancer binding protein beta |
increases expression affects expression |
ISO EXP |
Diclofenac results in increased expression of CEBPB mRNA Diclofenac affects the expression of CEBPB mRNA |
CTD |
PMID:19022234 PMID:24752500 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Cebpg |
CCAAT/enhancer binding protein gamma |
decreases expression |
ISO |
Diclofenac results in decreased expression of CEBPG mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
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G |
Cep162 |
centrosomal protein 162 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CEP162 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 8:88,149,726...88,208,249
Ensembl chr 8:88,149,726...88,206,830
|
|
G |
Cers6 |
ceramide synthase 6 |
increases expression |
ISO |
Diclofenac results in increased expression of CERS6 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848
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G |
Ces1d |
carboxylesterase 1D |
decreases expression |
ISO |
Diclofenac results in decreased expression of CES1D mRNA |
CTD |
PMID:26934552 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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|
G |
Cfap97d1 |
CFAP97 domain containing 1 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CFAP97D1 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr10:86,933,585...86,944,566
Ensembl chr10:86,933,808...86,938,244
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G |
Cfh |
complement factor H |
increases expression |
ISO |
Diclofenac results in increased expression of CFH mRNA |
CTD |
PMID:26934552 |
|
NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
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|
G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions affects expression |
ISO |
[Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein Diclofenac affects the expression of CFLAR mRNA |
CTD |
PMID:20237495 PMID:24752500 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Cgref1 |
cell growth regulator with EF hand domain 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CGREF1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852
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|
G |
Chac1 |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
increases expression decreases expression |
ISO |
Diclofenac results in increased expression of CHAC1 mRNA Diclofenac results in decreased expression of CHAC1 mRNA |
CTD |
PMID:26934552 PMID:35537566 |
|
NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
|
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G |
Chchd1 |
coiled-coil-helix-coiled-coil-helix domain containing 1 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CHCHD1 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr15:3,592,719...3,593,901
Ensembl chr15:3,592,727...3,593,901
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|
G |
Chdh |
choline dehydrogenase |
affects expression |
ISO |
Diclofenac affects the expression of CHDH mRNA |
CTD |
PMID:24752500 |
|
NCBI chr16:5,194,269...5,225,541
Ensembl chr16:5,194,269...5,225,537
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|
G |
Chek1 |
checkpoint kinase 1 |
affects expression |
ISO |
Diclofenac affects the expression of CHEK1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
|
|
G |
Chka |
choline kinase alpha |
affects expression |
ISO |
Diclofenac affects the expression of CHKA mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
|
|
G |
Chkb |
choline kinase beta |
affects expression |
ISO |
Diclofenac affects the expression of CHKB mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461
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|
G |
Chl1 |
cell adhesion molecule L1-like |
increases expression |
ISO |
Diclofenac results in increased expression of CHL1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265
|
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G |
Chst4 |
carbohydrate sulfotransferase 4 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CHST4 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr19:37,993,471...38,002,123
Ensembl chr19:37,991,417...38,003,608
|
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO EXP |
Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein] Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein] |
CTD |
PMID:15489888 PMID:25935278 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
|
|
G |
Cib1 |
calcium and integrin binding 1 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CIB1 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423
|
|
G |
Clec4a |
C-type lectin domain family 4, member A |
increases expression |
ISO |
Diclofenac results in increased expression of CLEC4N mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402
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G |
Clu |
clusterin |
increases expression multiple interactions |
ISO EXP |
Diclofenac results in increased expression of CLU protein [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein |
CTD |
PMID:23506792 PMID:25772430 |
|
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
|
|
G |
Cmpk2 |
cytidine/uridine monophosphate kinase 2 |
affects expression |
ISO |
Diclofenac affects the expression of CMPK2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183
|
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G |
Col3a1 |
collagen type III alpha 1 chain |
decreases expression multiple interactions |
ISO EXP |
Diclofenac results in decreased expression of COL3A1 mRNA [Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein] |
CTD |
PMID:26934552 PMID:31042592 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Cotl1 |
coactosin-like F-actin binding protein 1 |
increases expression |
ISO |
Diclofenac results in increased expression of COTL1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689
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G |
Cox4i2 |
cytochrome c oxidase subunit 4i2 |
increases expression |
ISO |
Diclofenac results in increased expression of COX4I2 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331
|
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G |
Cox6a2 |
cytochrome c oxidase subunit 6A2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of COX6A2 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274
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G |
Cpb2 |
carboxypeptidase B2 |
increases expression |
ISO |
Diclofenac results in increased expression of CPB2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
|
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G |
Cplx1 |
complexin 1 |
increases expression |
EXP |
Diclofenac results in increased expression of CPLX1 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr14:1,184,677...1,216,392
|
|
G |
Cplx4 |
complexin 4 |
increases expression |
EXP |
Diclofenac results in increased expression of CPLX4 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr18:59,481,360...59,504,716
Ensembl chr18:59,481,986...59,497,778
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G |
Cpne8 |
copine 8 |
increases expression |
ISO |
Diclofenac results in increased expression of CPNE8 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377
|
|
G |
Cpsf6 |
cleavage and polyadenylation specific factor 6 |
affects expression |
ISO |
Diclofenac affects the expression of CPSF6 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122
|
|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
ISO EXP |
Diclofenac results in increased expression of CPT1A mRNA |
CTD |
PMID:19022234 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
|
|
G |
Cr1l |
complement C3b/C4b receptor 1 like |
multiple interactions |
EXP |
[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein] |
CTD |
PMID:31042592 |
|
NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
|
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G |
Cr2 |
complement C3d receptor 2 |
affects expression |
ISO |
Diclofenac affects the expression of CR2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
|
|
G |
Creb3l2 |
cAMP responsive element binding protein 3-like 2 |
increases expression |
ISO |
Diclofenac results in increased expression of CREB3L2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763
|
|
G |
Creb3l4 |
cAMP responsive element binding protein 3-like 4 |
affects expression |
ISO |
Diclofenac affects the expression of CREB3L4 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932
|
|
G |
Crp |
C-reactive protein |
multiple interactions decreases expression |
EXP ISO |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CRP protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CRP protein]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Diclofenac results in decreased expression of CRP protein] Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein] |
CTD |
PMID:25772430 PMID:27313093 |
|
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
|
|
G |
Cry1 |
cryptochrome circadian regulator 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CRY1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
|
|
G |
Csf1 |
colony stimulating factor 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CSF1 mRNA |
CTD |
PMID:26934552 PMID:35537566 |
|
NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
|
|
G |
Csf1r |
colony stimulating factor 1 receptor |
increases expression increases secretion |
ISO |
Diclofenac results in increased expression of CSF1R mRNA Diclofenac results in increased secretion of CSF1R protein |
CTD |
PMID:26934552 |
|
NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
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Csf2rb |
colony stimulating factor 2 receptor subunit beta |
increases expression |
ISO |
Diclofenac results in increased expression of CSF2RB mRNA; Diclofenac results in increased expression of CSF2RB2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
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G |
Csnk2a1 |
casein kinase 2 alpha 1 |
affects expression |
ISO |
Diclofenac affects the expression of CSNK2A1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
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G |
Csnk2a2 |
casein kinase 2 alpha 2 |
affects expression |
ISO |
Diclofenac affects the expression of CSNK2A2 mRNA |
CTD |
PMID:24752500 |
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NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080
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G |
Csrnp3 |
cysteine and serine rich nuclear protein 3 |
increases expression |
EXP |
Diclofenac results in increased expression of CSRNP3 mRNA |
CTD |
PMID:30723492 |
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NCBI chr 3:50,498,379...50,695,598
Ensembl chr 3:50,498,633...50,685,950
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G |
Cstf2 |
cleavage stimulation factor subunit 2 |
affects expression |
ISO |
Diclofenac affects the expression of CSTF2 mRNA |
CTD |
PMID:24752500 |
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NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476
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G |
Cstf3 |
cleavage stimulation factor subunit 3 |
affects expression |
ISO |
Diclofenac affects the expression of CSTF3 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 3:90,966,415...91,037,669
Ensembl chr 3:90,966,354...91,042,196
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G |
Ctbp2 |
C-terminal binding protein 2 |
affects expression |
ISO |
Diclofenac affects the expression of CTBP2 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222
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G |
Cth |
cystathionine gamma-lyase |
affects expression decreases expression |
ISO |
Diclofenac affects the expression of CTH mRNA Diclofenac results in decreased expression of CTH mRNA |
CTD |
PMID:24752500 PMID:35537566 |
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NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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G |
Ctla4 |
cytotoxic T-lymphocyte-associated protein 4 |
increases expression |
ISO |
Diclofenac results in increased expression of CTLA4 protein |
CTD |
PMID:26934552 |
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NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
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G |
Ctnnb1 |
catenin beta 1 |
affects expression |
ISO |
Diclofenac affects the expression of CTNNB1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctps1 |
CTP synthase 1 |
affects expression |
ISO |
Diclofenac affects the expression of CTPS1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
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G |
Ctps2 |
CTP synthase 2 |
affects expression |
ISO |
Diclofenac affects the expression of CTPS2 mRNA |
CTD |
PMID:24752500 |
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NCBI chr X:31,645,873...31,786,733
Ensembl chr X:31,645,873...31,786,733
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G |
Ctsc |
cathepsin C |
increases expression |
ISO |
Diclofenac results in increased expression of CTSC mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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G |
Ctse |
cathepsin E |
decreases expression |
ISO |
Diclofenac results in decreased expression of CTSE mRNA |
CTD |
PMID:35537566 |
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NCBI chr13:43,091,954...43,114,509
Ensembl chr13:43,092,128...43,114,502
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G |
Ctss |
cathepsin S |
increases expression |
ISO |
Diclofenac results in increased expression of CTSS mRNA |
CTD |
PMID:26934552 |
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NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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G |
Cul3 |
cullin 3 |
affects expression |
ISO |
Diclofenac affects the expression of CUL3 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
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G |
Cul7 |
cullin 7 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CUL7 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 9:14,319,102...14,333,035
Ensembl chr 9:14,319,108...14,332,741
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions |
EXP |
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein] |
CTD |
PMID:23939143 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl13 |
C-X-C motif chemokine ligand 13 |
increases expression |
ISO |
Diclofenac results in increased expression of CXCL13 mRNA |
CTD |
PMID:26934552 |
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NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
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G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
increases expression |
ISO |
Diclofenac results in increased expression of CXCL14 mRNA |
CTD |
PMID:26934552 |
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NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
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Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions increases expression |
EXP ISO |
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 mRNA] Diclofenac results in increased expression of CXCL2 mRNA; Diclofenac results in increased expression of CXCL2 protein |
CTD |
PMID:22285467 PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression decreases expression |
ISO |
Diclofenac results in increased expression of CXCL1 mRNA; Diclofenac results in increased expression of CXCL1 protein Diclofenac results in decreased expression of CXCL1 mRNA |
CTD |
PMID:26934552 PMID:27671914 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CXCR4 mRNA |
CTD |
PMID:19192274 PMID:35537566 |
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NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cyb561 |
cytochrome b-561 |
increases expression |
ISO |
Diclofenac results in increased expression of CYB561 mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787
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Cyba |
cytochrome b-245 alpha chain |
increases expression |
ISO |
Diclofenac results in increased expression of CYBA mRNA |
CTD |
PMID:26934552 |
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NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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G |
Cybb |
cytochrome b-245 beta chain |
increases expression |
ISO |
Diclofenac results in increased expression of CYBB mRNA |
CTD |
PMID:26934552 |
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NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Cycs |
cytochrome c, somatic |
affects expression |
ISO |
Diclofenac affects the expression of CYCS mRNA |
CTD |
PMID:24752500 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases expression |
ISO |
Diclofenac results in increased expression of CYP17A1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of CYP19A1 mRNA |
CTD |
PMID:37844793 |
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NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression decreases activity |
ISO |
Diclofenac results in increased expression of CYP1A1 mRNA; Diclofenac results in increased expression of CYP1A1 protein Diclofenac results in decreased activity of CYP1A1 protein |
CTD |
PMID:18420780 PMID:21784029 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression decreases activity multiple interactions |
ISO |
Diclofenac results in increased expression of CYP1A2 mRNA; Diclofenac results in increased expression of CYP1A2 protein Diclofenac metabolite results in decreased activity of CYP1A2 protein [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac |
CTD |
PMID:21784029 PMID:23397584 PMID:28960974 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Diclofenac results in decreased activity of CYP1B1 protein |
CTD |
PMID:18420780 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CYP26A1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Cyp26b1 |
cytochrome P450, family 26, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of CYP26B1 mRNA |
CTD |
PMID:37844793 |
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NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
decreases activity affects expression |
ISO |
Diclofenac results in decreased activity of CYP2A4 protein Diclofenac affects the expression of CYP2A4 mRNA |
CTD |
PMID:18420780 PMID:26934552 |
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NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
decreases activity |
ISO |
Diclofenac results in decreased activity of CYP2B10 protein |
CTD |
PMID:18420780 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c24 |
cytochrome P450, family 2, subfamily c, polypeptide 24 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CYP2C55 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
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Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
increases hydroxylation decreases activity increases response to substance multiple interactions |
EXP ISO |
CYP2C6 protein results in increased hydroxylation of Diclofenac Diclofenac results in decreased activity of CYP2C29 protein CYP2C19 protein results in increased susceptibility to Diclofenac [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac CYP2C19 protein results in increased hydroxylation of Diclofenac |
CTD |
PMID:11911841 PMID:15486075 PMID:18420780 PMID:18511451 PMID:23397584 PMID:28762043 More...
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c7 |
cytochrome P450, family 2, subfamily c, polypeptide 7 |
affects metabolic processing |
EXP |
CYP2C9 protein affects the metabolism of Diclofenac |
CTD |
PMID:15801540 |
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NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac |
CTD |
PMID:23397584 PMID:24246759 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
Diclofenac metabolite results in decreased activity of CYP2E1 protein |
CTD |
PMID:28960974 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp39a1 |
cytochrome P450, family 39, subfamily a, polypeptide 1 |
increases expression |
ISO |
Diclofenac results in increased expression of CYP39A1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity increases metabolic processing increases expression multiple interactions increases response to substance |
ISO |
Diclofenac metabolite results in decreased activity of CYP3A4 protein; Diclofenac results in decreased activity of CYP3A4 protein CYP3A4 protein results in increased metabolism of Diclofenac Diclofenac results in increased expression of CYP3A4 mRNA [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac CYP3A4 protein results in increased susceptibility to Diclofenac |
CTD |
PMID:15135088 PMID:19022234 PMID:23397584 PMID:24104198 PMID:24246759 PMID:28762043 PMID:28960974 PMID:29027214 PMID:33259822 More...
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases expression |
EXP |
Diclofenac results in increased expression of CYP3A23-3A1 mRNA |
CTD |
PMID:19022234 PMID:29027214 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
decreases activity increases expression |
ISO |
Diclofenac metabolite results in decreased activity of CYP3A13 protein Diclofenac results in increased expression of CYP3A13 mRNA |
CTD |
PMID:26934552 PMID:28960974 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Cyp46a1 |
cytochrome P450, family 46, subfamily a, polypeptide 1 |
increases hydroxylation |
ISO |
CYP46A1 protein results in increased hydroxylation of Diclofenac |
CTD |
PMID:14640697 |
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NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760
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G |
Cyp4f39 |
cytochrome P450, family 4, subfamily f, polypeptide 39 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CYP4F39 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 7:11,426,806...11,505,553
Ensembl chr 7:11,433,371...11,536,181
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G |
Cyp4v3 |
cytochrome P450, family 4, subfamily v, polypeptide 3 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CYP4V3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395
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G |
Cyp51 |
cytochrome P450, family 51 |
decreases activity increases expression |
ISO |
Diclofenac metabolite results in decreased activity of CYP51A1 protein Diclofenac results in increased expression of CYP51 mRNA |
CTD |
PMID:26934552 PMID:28960974 |
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NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases expression |
ISO |
Diclofenac results in increased expression of CYP7A1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Cyp8b1 |
cytochrome P450 family 8 subfamily B member 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of CYP8B1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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G |
Dap |
death-associated protein |
increases expression |
ISO |
Diclofenac results in increased expression of DAP mRNA |
CTD |
PMID:26934552 |
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NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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G |
Dbt |
dihydrolipoamide branched chain transacylase E2 |
affects expression |
ISO |
Diclofenac affects the expression of DBT mRNA |
CTD |
PMID:24752500 |
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NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609
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G |
Dctpp1 |
dCTP pyrophosphatase 1 |
affects expression |
ISO |
Diclofenac affects the expression of DCTPP1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 1:181,877,440...181,880,833
Ensembl chr 1:181,877,437...181,880,839
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases response to substance decreases expression increases expression |
ISO EXP |
DDIT3 results in increased susceptibility to Diclofenac Diclofenac results in decreased expression of DDIT3 mRNA Diclofenac results in increased expression of DDIT3 mRNA; Diclofenac results in increased expression of DDIT3 protein |
CTD |
PMID:18172885 PMID:20668000 PMID:24752500 PMID:27313093 PMID:27358234 PMID:35537566 More...
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4 |
DNA-damage-inducible transcript 4 |
increases expression |
ISO |
Diclofenac results in increased expression of DDIT4 mRNA |
CTD |
PMID:26934552 |
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NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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G |
Ddr1 |
discoidin domain receptor tyrosine kinase 1 |
affects expression |
ISO |
Diclofenac affects the expression of DDR1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
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G |
Ddt |
D-dopachrome tautomerase |
decreases expression |
ISO |
Diclofenac results in decreased expression of DDT mRNA |
CTD |
PMID:26934552 |
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NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482
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G |
Ddx5 |
DEAD-box helicase 5 |
affects expression |
ISO |
Diclofenac affects the expression of DDX5 mRNA |
CTD |
PMID:24752500 |
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NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283
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G |
Decr1 |
2,4-dienoyl-CoA reductase 1 |
increases expression |
EXP |
Diclofenac results in increased expression of DECR1 protein |
CTD |
PMID:25772430 |
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NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
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G |
Dennd2d |
DENN domain containing 2D |
decreases expression |
ISO |
Diclofenac results in decreased expression of DENND2D mRNA |
CTD |
PMID:35537566 |
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NCBI chr 2:193,973,231...193,992,275
Ensembl chr 2:193,973,231...193,992,270
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G |
Derl1 |
derlin 1 |
increases expression |
ISO |
Diclofenac results in increased expression of DERL1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145
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G |
Derl3 |
derlin 3 |
increases expression |
ISO |
Diclofenac results in increased expression of DERL3 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027
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G |
Dffa |
DNA fragmentation factor subunit alpha |
affects expression |
ISO |
Diclofenac affects the expression of DFFA mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
increases expression |
ISO |
Diclofenac results in increased expression of DHCR24 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhfr |
dihydrofolate reductase |
affects expression |
ISO |
Diclofenac affects the expression of DHFR mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
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G |
Dhrs3 |
dehydrogenase/reductase 3 |
decreases expression |
ISO |
Diclofenac results in decreased expression of DHRS3 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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G |
Dkk1 |
dickkopf WNT signaling pathway inhibitor 1 |
affects expression |
ISO |
Diclofenac affects the expression of DKK1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
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G |
Dnaaf2 |
dynein, axonemal, assembly factor 2 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of DNAAF2 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 6:87,661,101...87,670,267
Ensembl chr 6:87,660,821...87,670,199
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G |
Dnaja1 |
DnaJ heat shock protein family (Hsp40) member A1 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJA1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
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G |
Dnaja2 |
DnaJ heat shock protein family (Hsp40) member A2 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJA2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901
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G |
Dnaja3 |
DnaJ heat shock protein family (Hsp40) member A3 |
affects expression decreases expression |
ISO |
Diclofenac affects the expression of DNAJA3 mRNA Diclofenac results in decreased expression of DNAJA3 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
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NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
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G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJB1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
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G |
Dnajb14 |
DnaJ heat shock protein family (Hsp40) member B14 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJB14 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490
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G |
Dnajb4 |
DnaJ heat shock protein family (Hsp40) member B4 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJB4 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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G |
Dnajb6 |
DnaJ heat shock protein family (Hsp40) member B6 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJB6 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659
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G |
Dnajb7 |
DnaJ heat shock protein family (Hsp40) member B7 |
increases expression |
EXP |
Diclofenac results in increased expression of DNAJB7 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr 7:112,932,736...112,934,050
Ensembl chr 7:112,932,616...112,945,537
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
affects expression increases expression |
ISO |
Diclofenac affects the expression of DNAJB9 mRNA Diclofenac results in increased expression of DNAJB9 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
|
NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Dnajc10 |
DnaJ heat shock protein family (Hsp40) member C10 |
affects expression increases expression |
ISO |
Diclofenac affects the expression of DNAJC10 mRNA Diclofenac results in increased expression of DNAJC10 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
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NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719
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G |
Dnajc11 |
DnaJ heat shock protein family (Hsp40) member C11 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJC11 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:162,442,042...162,487,966
Ensembl chr 5:162,442,026...162,488,169
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G |
Dnajc12 |
DnaJ heat shock protein family (Hsp40) member C12 |
increases expression decreases expression |
ISO |
Diclofenac results in increased expression of DNAJC12 mRNA Diclofenac results in decreased expression of DNAJC12 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521
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G |
Dnajc15 |
DnaJ heat shock protein family (Hsp40) member C15 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJC15 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
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G |
Dnajc18 |
DnaJ heat shock protein family (Hsp40) member C18 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJC18 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr18:27,269,350...27,303,453
Ensembl chr18:27,269,355...27,298,344
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G |
Dnajc21 |
DnaJ heat shock protein family (Hsp40) member C21 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJC21 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:59,419,507...59,446,746
Ensembl chr 2:59,419,510...59,446,752
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G |
Dnajc3 |
DnaJ heat shock protein family (Hsp40) member C3 |
increases expression |
ISO |
Diclofenac results in increased expression of DNAJC3 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
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G |
Dnajc5 |
DnaJ heat shock protein family (Hsp40) member C5 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJC5 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935
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G |
Dnajc6 |
DnaJ heat shock protein family (Hsp40) member C6 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJC6 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:116,120,069...116,283,448
Ensembl chr 5:116,119,676...116,283,448
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G |
Dnajc7 |
DnaJ heat shock protein family (Hsp40) member C7 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJC7 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575
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G |
Dnajc8 |
DnaJ heat shock protein family (Hsp40) member C8 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJC8 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:144,745,055...144,763,106
Ensembl chr 5:144,745,036...144,763,108
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G |
Dnajc9 |
DnaJ heat shock protein family (Hsp40) member C9 |
affects expression |
ISO |
Diclofenac affects the expression of DNAJC9 mRNA |
CTD |
PMID:24752500 |
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NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118
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G |
Dnd1 |
DND microRNA-mediated repression inhibitor 1 |
increases expression |
ISO |
Diclofenac results in increased expression of DND1 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr18:28,378,692...28,381,316
Ensembl chr18:28,378,692...28,381,316
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G |
Dner |
delta/notch-like EGF repeat containing |
decreases expression |
ISO |
Diclofenac results in decreased expression of DNER mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637
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G |
Dpysl2 |
dihydropyrimidinase-like 2 |
affects expression |
ISO |
Diclofenac affects the expression of DPYSL2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
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G |
Drd1 |
dopamine receptor D1 |
increases expression |
ISO |
Diclofenac results in increased expression of DRD1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Dtymk |
deoxythymidylate kinase |
affects expression |
ISO |
Diclofenac affects the expression of DTYMK mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
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G |
Dusp1 |
dual specificity phosphatase 1 |
affects expression decreases expression |
ISO |
Diclofenac affects the expression of DUSP1 mRNA Diclofenac results in decreased expression of DUSP1 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
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NCBI chr10:16,680,478...16,683,275
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G |
Dut |
deoxyuridine triphosphatase |
affects expression |
ISO |
Diclofenac affects the expression of DUT mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
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G |
Dync1i1 |
dynein cytoplasmic 1 intermediate chain 1 |
increases expression |
EXP |
Diclofenac results in increased expression of DYNC1I1 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149
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G |
E2f1 |
E2F transcription factor 1 |
affects expression |
ISO |
Diclofenac affects the expression of E2F1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f2 |
E2F transcription factor 2 |
affects expression |
ISO |
Diclofenac affects the expression of E2F2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
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G |
E2f5 |
E2F transcription factor 5 |
affects expression |
ISO |
Diclofenac affects the expression of E2F5 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
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G |
Ebln1 |
endogenous Bornavirus like nucleoprotein 1 |
increases expression |
EXP |
Diclofenac results in increased expression of IGKV8-24 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr10:78,938,645...78,940,651
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|
G |
Ecm1 |
extracellular matrix protein 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ECM1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
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G |
Ect2 |
epithelial cell transforming 2 |
increases expression |
ISO |
Diclofenac results in increased expression of ECT2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
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G |
Edem1 |
ER degradation enhancing alpha-mannosidase like protein 1 |
increases expression |
ISO |
Diclofenac results in increased expression of EDEM1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
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G |
Edil3 |
EGF like repeats and discoidin domains 3 |
decreases expression |
ISO |
Diclofenac results in decreased expression of EDIL3 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium] |
CTD |
PMID:15083534 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Edn2 |
endothelin 2 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of EDN2 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
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G |
Eef2k |
eukaryotic elongation factor-2 kinase |
decreases expression |
ISO |
Diclofenac results in decreased expression of EEF2K mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164
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G |
Egf |
epidermal growth factor |
increases expression |
ISO |
Diclofenac results in increased expression of EGF protein |
CTD |
PMID:23506792 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
increases expression |
ISO |
Diclofenac results in increased expression of EGFR mRNA |
CTD |
PMID:26934552 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
increases expression multiple interactions affects expression |
ISO |
Diclofenac results in increased expression of EGR1 mRNA [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of EGR1 mRNA Diclofenac affects the expression of EGR1 mRNA |
CTD |
PMID:15509713 PMID:26934552 PMID:37844793 |
|
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Eif1 |
eukaryotic translation initiation factor 1 |
affects expression |
ISO |
Diclofenac affects the expression of EIF1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
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G |
Eif1a |
eukaryotic translation initiation factor 1A |
increases expression |
ISO |
Diclofenac results in increased expression of EIF1A mRNA |
CTD |
PMID:26934552 |
|
NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696
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G |
Eif1ax |
eukaryotic translation initiation factor 1A, X-linked |
affects expression |
ISO |
Diclofenac affects the expression of EIF1AX mRNA |
CTD |
PMID:24752500 |
|
NCBI chr X:35,498,698...35,513,402
Ensembl chr X:35,498,517...35,513,335
|
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
affects expression |
ISO |
Diclofenac affects the expression of EIF2A mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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G |
Eif2ak1 |
eukaryotic translation initiation factor 2 alpha kinase 1 |
affects expression decreases expression |
ISO |
Diclofenac affects the expression of EIF2AK1 mRNA Diclofenac results in decreased expression of EIF2AK1 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
|
NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
affects expression increases expression increases phosphorylation multiple interactions increases activity |
ISO |
Diclofenac affects the expression of EIF2AK3 mRNA Diclofenac results in increased expression of EIF2AK3 mRNA Diclofenac results in increased phosphorylation of EIF2AK3 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein] Diclofenac results in increased activity of EIF2AK3 protein |
CTD |
PMID:24752500 PMID:26609140 PMID:26934552 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2ak4 |
eukaryotic translation initiation factor 2 alpha kinase 4 |
affects expression |
ISO |
Diclofenac affects the expression of EIF2AK4 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630
|
|
G |
Eif2b1 |
eukaryotic translation initiation factor 2B subunit alpha |
affects expression |
ISO |
Diclofenac affects the expression of EIF2B1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601
|
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
affects expression multiple interactions |
ISO |
Diclofenac affects the expression of EIF2S1 mRNA [TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:24752500 PMID:27313093 |
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Eif2s2 |
eukaryotic translation initiation factor 2 subunit beta |
affects expression |
ISO |
Diclofenac affects the expression of EIF2S2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
|
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G |
Eif3a |
eukaryotic translation initiation factor 3, subunit A |
affects expression |
ISO |
Diclofenac affects the expression of EIF3A mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976
|
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G |
Eif3b |
eukaryotic translation initiation factor 3, subunit B |
affects expression |
ISO |
Diclofenac affects the expression of EIF3B mRNA |
CTD |
PMID:24752500 |
|
NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886
|
|
G |
Eif3c |
eukaryotic translation initiation factor 3, subunit C |
affects expression |
ISO |
Diclofenac affects the expression of EIF3C mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
|
|
G |
Eif4a1 |
eukaryotic translation initiation factor 4A1 |
affects expression |
ISO |
Diclofenac affects the expression of EIF4A1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858
|
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G |
Eif4a2 |
eukaryotic translation initiation factor 4A2 |
affects expression |
ISO |
Diclofenac affects the expression of EIF4A2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
|
|
G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
increases expression decreases expression affects expression |
EXP ISO |
Diclofenac results in increased expression of EIF4EBP1 mRNA Diclofenac results in decreased expression of EIF4EBP1 mRNA Diclofenac affects the expression of EIF4EBP1 mRNA |
CTD |
PMID:18172885 PMID:24752500 PMID:35537566 |
|
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
|
|
G |
Eif4g1 |
eukaryotic translation initiation factor 4 gamma 1 |
affects expression |
ISO |
Diclofenac affects the expression of EIF4G1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
|
|
G |
Eif4g3 |
eukaryotic translation initiation factor 4 gamma, 3 |
affects expression |
ISO |
Diclofenac affects the expression of EIF4G3 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:150,197,410...150,418,862
Ensembl chr 5:150,195,226...150,418,363
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G |
Eif5 |
eukaryotic translation initiation factor 5 |
affects expression |
ISO |
Diclofenac affects the expression of EIF5 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656
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|
G |
Elf2 |
E74 like ETS transcription factor 2 |
affects expression |
ISO |
Diclofenac affects the expression of ELF2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947
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G |
Elf3 |
E74 like ETS transcription factor 3 |
affects expression |
ISO |
Diclofenac affects the expression of ELF3 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481
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G |
Elovl2 |
ELOVL fatty acid elongase 2 |
affects expression |
ISO |
Diclofenac affects the expression of ELOVL2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848
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G |
Elovl6 |
ELOVL fatty acid elongase 6 |
increases expression |
ISO |
Diclofenac results in increased expression of ELOVL6 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
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G |
Eme2 |
essential meiotic structure-specific endonuclease subunit 2 |
increases expression |
ISO |
Diclofenac results in increased expression of EME2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968
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G |
Endog |
endonuclease G |
affects expression |
ISO |
Diclofenac affects the expression of ENDOG mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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G |
Eno1 |
enolase 1 |
increases expression |
ISO |
Diclofenac results in increased expression of ENO1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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|
G |
Enpp1 |
ectonucleotide pyrophosphatase/phosphodiesterase 1 |
affects expression |
ISO |
Diclofenac affects the expression of ENPP1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
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G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
increases expression |
ISO |
Diclofenac results in increased expression of ENPP2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
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|
G |
Entpd4 |
ectonucleoside triphosphate diphosphohydrolase 4 |
affects expression |
ISO |
Diclofenac affects the expression of ENTPD4 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr15:44,630,878...44,658,654
Ensembl chr15:44,630,873...44,658,706
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G |
Entpd5 |
ectonucleoside triphosphate diphosphohydrolase 5 |
affects expression |
ISO |
Diclofenac affects the expression of ENTPD5 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
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G |
Entpd7 |
ectonucleoside triphosphate diphosphohydrolase 7 |
affects expression |
ISO |
Diclofenac affects the expression of ENTPD7 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:242,559,365...242,601,044
Ensembl chr 1:242,559,365...242,601,447
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G |
Epas1 |
endothelial PAS domain protein 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of EPAS1 protein |
CTD |
PMID:12912967 |
|
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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G |
Epc2 |
enhancer of polycomb homolog 2 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of EPC2 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 3:33,867,219...33,967,908
Ensembl chr 3:33,867,219...33,967,150
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G |
Ephx1 |
epoxide hydrolase 1 |
decreases expression |
EXP |
Diclofenac results in decreased expression of EPHX1 mRNA |
CTD |
PMID:17202759 |
|
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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G |
Epn2 |
epsin 2 |
affects expression |
ISO |
Diclofenac affects the expression of EPN2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr10:46,197,785...46,259,673
Ensembl chr10:46,197,785...46,259,642
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G |
Epn3 |
epsin 3 |
affects expression |
ISO |
Diclofenac affects the expression of EPN3 mRNA |
CTD |
PMID:24752500 |
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NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356
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G |
Epo |
erythropoietin |
affects expression |
ISO |
Diclofenac affects the expression of EPO mRNA |
CTD |
PMID:24752500 |
|
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Erbb4 |
erb-b2 receptor tyrosine kinase 4 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ERBB4 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
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G |
Ereg |
epiregulin |
increases expression |
ISO |
Diclofenac results in increased expression of EREG mRNA |
CTD |
PMID:32816093 |
|
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
affects expression |
ISO |
Diclofenac affects the expression of ERN1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Ero1a |
endoplasmic reticulum oxidoreductase 1 alpha |
increases expression |
ISO |
Diclofenac results in increased expression of ERO1A mRNA |
CTD |
PMID:26934552 |
|
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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G |
Esr1 |
estrogen receptor 1 |
affects activity |
ISO |
Diclofenac affects the activity of ESR1 protein |
CTD |
PMID:29777833 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Etnppl |
ethanolamine-phosphate phospho-lyase |
decreases expression |
ISO |
Diclofenac results in decreased expression of ETNPPL mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212
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G |
Evi5 |
ecotropic viral integration site 5 |
decreases expression |
ISO |
Diclofenac results in decreased expression of EVI5 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678
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G |
Extl1 |
exostosin-like glycosyltransferase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of EXTL1 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 5:146,573,911...146,589,115
Ensembl chr 5:146,573,912...146,589,115
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G |
Eya4 |
EYA transcriptional coactivator and phosphatase 4 |
decreases expression |
ISO |
Diclofenac results in decreased expression of EYA4 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 1:22,172,275...22,415,978
Ensembl chr 1:22,172,275...22,415,976
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G |
F13a1 |
coagulation factor XIII A1 chain |
increases expression |
ISO |
Diclofenac results in increased expression of F13A1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
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G |
Faap24 |
FA core complex associated protein 24 |
increases expression |
ISO |
Diclofenac results in increased expression of FAAP24 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 1:88,051,523...88,057,997
Ensembl chr 1:88,051,911...88,057,989
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G |
Fabp1 |
fatty acid binding protein 1 |
decreases expression increases expression |
ISO |
Diclofenac results in decreased expression of FABP1 mRNA Diclofenac results in increased expression of FABP1 protein |
CTD |
PMID:19022234 PMID:23506792 |
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NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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G |
Fabp2 |
fatty acid binding protein 2 |
decreases expression |
EXP ISO |
Diclofenac results in decreased expression of FABP2 mRNA |
CTD |
PMID:19022234 PMID:26934552 |
|
NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
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G |
Fabp3 |
fatty acid binding protein 3 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FABP3 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO |
Diclofenac results in decreased expression of FABP4 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fabp5 |
fatty acid binding protein 5 |
increases expression |
ISO |
Diclofenac results in increased expression of FABP5 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
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G |
Fads1 |
fatty acid desaturase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of FADS1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
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G |
Fam209 |
family with sequence similarity 209 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FAM209 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 3:161,240,062...161,241,747
Ensembl chr 3:161,240,034...161,241,755
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G |
Fancb |
FA complementation group B |
affects expression |
ISO |
Diclofenac affects the expression of FANCB mRNA |
CTD |
PMID:24752500 |
|
NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192
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G |
Fancc |
FA complementation group C |
affects expression |
ISO |
Diclofenac affects the expression of FANCC mRNA |
CTD |
PMID:24752500 |
|
NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376
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G |
Fance |
FA complementation group E |
increases expression |
ISO |
Diclofenac results in increased expression of FANCE mRNA |
CTD |
PMID:26934552 |
|
NCBI chr20:6,369,416...6,386,631
Ensembl chr20:6,375,573...6,386,631
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G |
Fancf |
FA complementation group F |
affects expression |
ISO |
Diclofenac affects the expression of FANCF mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923
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G |
Fancg |
FA complementation group G |
affects expression |
ISO |
Diclofenac affects the expression of FANCG mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029
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G |
Fancl |
FA complementation group L |
affects expression |
ISO |
Diclofenac affects the expression of FANCL mRNA |
CTD |
PMID:24752500 |
|
NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255
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G |
Fancm |
FA complementation group M |
affects expression |
ISO |
Diclofenac affects the expression of FANCM mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028
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G |
Fas |
Fas cell surface death receptor |
affects expression increases expression |
ISO |
Diclofenac affects the expression of FAS mRNA Diclofenac results in increased expression of FAS mRNA |
CTD |
PMID:24752500 PMID:26934552 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
increases expression |
ISO |
Diclofenac results in increased expression of FASL mRNA |
CTD |
PMID:22285467 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
decreases expression |
EXP |
Diclofenac results in decreased expression of FASN mRNA |
CTD |
PMID:19022234 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
|
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G |
Fastk |
Fas-activated serine/threonine kinase |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FASTK mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 4:10,732,273...10,736,332
Ensembl chr 4:10,732,256...10,737,430
|
|
G |
Fastkd2 |
FAST kinase domains 2 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FASTKD2 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 9:65,166,148...65,188,184
Ensembl chr 9:65,168,228...65,188,174
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G |
Fbxo33 |
F-box protein 33 |
increases expression |
ISO |
Diclofenac results in increased expression of FBXO33 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 6:76,900,619...76,934,232
Ensembl chr 6:76,900,631...76,932,669
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G |
Fbxo5 |
F-box protein 5 |
decreases expression |
ISO |
Diclofenac results in decreased expression of FBXO5 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
|
|
G |
Fcer1g |
Fc epsilon receptor Ig |
increases expression |
ISO |
Diclofenac results in increased expression of FCER1G mRNA |
CTD |
PMID:26934552 |
|
NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443
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G |
Fcgr2a |
Fc gamma receptor 2A |
increases expression |
ISO |
Diclofenac results in increased expression of FCGR3 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
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G |
Fcgr2b |
Fc gamma receptor 2B |
decreases expression |
ISO |
Diclofenac results in decreased expression of FCGR2B mRNA |
CTD |
PMID:35537566 |
|
NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
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G |
Fen1 |
flap structure-specific endonuclease 1 |
increases expression |
ISO |
Diclofenac results in increased expression of FEN1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
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|
G |
Fer |
FER tyrosine kinase |
affects expression |
ISO |
Diclofenac affects the expression of FER mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451
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G |
Fermt1 |
FERM domain containing kindlin 1 |
increases expression |
EXP |
Diclofenac results in increased expression of FERMT1 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr 3:120,171,301...120,213,555
Ensembl chr 3:120,171,561...120,213,555
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|
G |
Fgb |
fibrinogen beta chain |
multiple interactions increases expression |
EXP ISO |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGB protein Diclofenac results in increased expression of FGB mRNA |
CTD |
PMID:25772430 PMID:26934552 |
|
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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G |
Fgf1 |
fibroblast growth factor 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of FGF1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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|
G |
Fgf3 |
fibroblast growth factor 3 |
increases expression |
ISO |
Diclofenac results in increased expression of FGF3 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 1:200,001,162...200,005,539
Ensembl chr 1:200,001,261...200,005,187
|
|
G |
Fgfr1 |
Fibroblast growth factor receptor 1 |
affects expression |
ISO |
Diclofenac affects the expression of FGFR1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
|
|
G |
Fgfr1op2 |
FGFR1 oncogene partner 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of FGFR1OP2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 4:179,491,602...179,512,630
Ensembl chr 4:179,491,599...179,512,630
|
|
G |
Fgg |
fibrinogen gamma chain |
multiple interactions decreases expression |
EXP |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGG protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in decreased expression of FGG protein] |
CTD |
PMID:25772430 |
|
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
|
|
G |
Fgl1 |
fibrinogen-like 1 |
increases expression |
ISO |
Diclofenac results in increased expression of FGL1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093
|
|
G |
Fmod |
fibromodulin |
decreases expression |
ISO |
Diclofenac results in decreased expression of FMOD mRNA |
CTD |
PMID:26934552 |
|
NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133
|
|
G |
Fn1 |
fibronectin 1 |
increases expression |
ISO |
Diclofenac results in increased expression of FN1 mRNA; Diclofenac results in increased expression of FN1 protein |
CTD |
PMID:26934552 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
Fnbp1 |
formin binding protein 1 |
affects expression |
ISO |
Diclofenac affects the expression of FNBP1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 3:14,309,067...14,424,378
Ensembl chr 3:14,309,640...14,424,881
|
|
G |
Fndc3b |
fibronectin type III domain containing 3B |
increases expression |
ISO |
Diclofenac results in increased expression of FNDC3B mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830
|
|
G |
Fnip1 |
folliculin interacting protein 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of FNIP1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824
|
|
G |
Fnip2 |
folliculin interacting protein 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of FNIP2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions affects expression |
ISO |
Diclofenac results in increased expression of FOS mRNA [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FOS mRNA Diclofenac affects the expression of FOS mRNA |
CTD |
PMID:12730611 PMID:24752500 PMID:37844793 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
increases expression |
ISO |
Diclofenac results in increased expression of FOSL2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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G |
Foxa1 |
forkhead box A1 |
affects expression |
ISO |
Diclofenac affects the expression of FOXA1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
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G |
Foxa3 |
forkhead box A3 |
increases expression |
ISO |
Diclofenac results in increased expression of FOXA3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155
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G |
Foxo1 |
forkhead box O1 |
affects expression |
ISO |
Diclofenac affects the expression of FOXO1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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|
G |
Foxo3 |
forkhead box O3 |
affects expression decreases expression |
ISO |
Diclofenac affects the expression of FOXO3 mRNA Diclofenac results in decreased expression of FOXO3 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
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NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
Fpr2 |
formyl peptide receptor 2 |
increases expression |
ISO |
Diclofenac results in increased expression of FPR2 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019
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G |
Frat2 |
FRAT regulator of WNT signaling pathway 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of FRAT2 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 1:240,654,120...240,656,449
Ensembl chr 1:240,654,137...240,656,517
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G |
Frs2 |
fibroblast growth factor receptor substrate 2 |
affects expression |
ISO |
Diclofenac affects the expression of FRS2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 7:52,711,255...52,792,738
Ensembl chr 7:52,711,257...52,792,743
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G |
Ftcd |
formimidoyltransferase cyclodeaminase |
affects expression |
ISO |
Diclofenac affects the expression of FTCD mRNA |
CTD |
PMID:24752500 |
|
NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735
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G |
Fyb1 |
FYN binding protein 1 |
increases expression |
ISO |
Diclofenac results in increased expression of FYB1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629
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G |
Fzd3 |
frizzled class receptor 3 |
affects expression |
ISO |
Diclofenac affects the expression of FZD3 mRNA |
CTD |
PMID:24752500 |
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NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369
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G |
Fzd4 |
frizzled class receptor 4 |
affects expression |
ISO |
Diclofenac affects the expression of FZD4 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 1:143,279,934...143,288,799
Ensembl chr 1:143,280,065...143,285,724
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G |
Fzd5 |
frizzled class receptor 5 |
affects expression |
ISO |
Diclofenac affects the expression of FZD5 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457
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G |
Fzd6 |
frizzled class receptor 6 |
affects expression |
ISO |
Diclofenac affects the expression of FZD6 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776
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G |
Fzd7 |
frizzled class receptor 7 |
affects expression |
ISO |
Diclofenac affects the expression of FZD7 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
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G |
Gab1 |
GRB2-associated binding protein 1 |
affects expression |
ISO |
Diclofenac affects the expression of GAB1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236
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G |
Gab2 |
GRB2-associated binding protein 2 |
affects expression |
ISO |
Diclofenac affects the expression of GAB2 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
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G |
Gabra5 |
gamma-aminobutyric acid type A receptor subunit alpha 5 |
decreases expression |
ISO |
Diclofenac results in decreased expression of GABRA5 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression decreases expression affects expression |
ISO EXP |
Diclofenac results in increased expression of GADD45A mRNA Diclofenac results in decreased expression of GADD45A mRNA Diclofenac affects the expression of GADD45A mRNA |
CTD |
PMID:18172885 PMID:19022234 PMID:24752500 PMID:26934552 PMID:35537566 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
increases expression |
ISO |
Diclofenac results in increased expression of GADD45G mRNA |
CTD |
PMID:26934552 |
|
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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G |
Galnt3 |
polypeptide N-acetylgalactosaminyltransferase 3 |
increases expression |
EXP |
Diclofenac results in increased expression of GALNT3 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268
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G |
Gars1 |
glycyl-tRNA synthetase 1 |
affects expression decreases expression |
ISO |
Diclofenac affects the expression of GARS1 mRNA Diclofenac results in decreased expression of GARS1 mRNA |
CTD |
PMID:24752500 PMID:35537566 |
|
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
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G |
Gart |
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase |
affects expression |
ISO |
Diclofenac affects the expression of GART mRNA |
CTD |
PMID:24752500 |
|
NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125
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G |
Gas1 |
growth arrest-specific 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of GAS1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr17:4,482,168...4,485,153
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G |
Gata4 |
GATA binding protein 4 |
affects expression |
ISO |
Diclofenac affects the expression of GATA4 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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G |
Gata6 |
GATA binding protein 6 |
increases expression |
ISO |
Diclofenac results in increased expression of GATA6 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
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G |
Gbp1 |
guanylate binding protein 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of GBP1 mRNA |
CTD |
PMID:19192274 |
|
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
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G |
Gbp4 |
guanylate binding protein 4 |
increases expression |
ISO |
Diclofenac results in increased expression of GBP3 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879
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G |
Gc |
GC, vitamin D binding protein |
multiple interactions |
EXP |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GC protein |
CTD |
PMID:25772430 |
|
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
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G |
Gck |
glucokinase |
affects expression |
ISO |
Diclofenac affects the expression of GCK mRNA |
CTD |
PMID:26934552 |
|
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
decreases expression affects expression affects response to substance |
EXP ISO |
Diclofenac results in decreased expression of GCLC mRNA Diclofenac affects the expression of GCLC mRNA GCLC protein affects the susceptibility to Diclofenac |
CTD |
PMID:17202759 PMID:19481141 PMID:24752500 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
affects expression |
ISO |
Diclofenac affects the expression of GCLM mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
Diclofenac results in increased expression of GDF15 mRNA Diclofenac results in increased expression of GDF15 protein |
CTD |
PMID:15555568 PMID:18076062 |
|
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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G |
Gdf6 |
growth differentiation factor 6 |
increases expression |
EXP |
Diclofenac results in increased expression of GDF6 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567
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G |
Gdf9 |
growth differentiation factor 9 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of GDF9 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
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G |
Gfpt1 |
glutamine fructose-6-phosphate transaminase 1 |
increases expression |
ISO |
Diclofenac results in increased expression of GFPT1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
EXP |
[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GGT1 protein |
CTD |
PMID:23939143 |
|
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Ghr |
growth hormone receptor |
affects expression |
ISO |
Diclofenac affects the expression of GHR protein |
CTD |
PMID:26934552 |
|
NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
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G |
Git2 |
GIT ArfGAP 2 |
affects expression |
ISO |
Diclofenac affects the expression of GIT2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097
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G |
Gja1 |
gap junction protein, alpha 1 |
increases expression |
ISO |
Diclofenac results in increased expression of GJA1 mRNA |
CTD |
PMID:26934552 PMID:35537566 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gja3 |
gap junction protein, alpha 3 |
increases expression |
ISO |
Diclofenac results in increased expression of GJA3 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr15:31,181,360...31,206,820
Ensembl chr15:31,181,369...31,206,810
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G |
Gldc |
glycine decarboxylase |
affects expression |
ISO |
Diclofenac affects the expression of GLDC mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097
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G |
Glyctk |
glycerate kinase |
affects expression |
ISO |
Diclofenac affects the expression of GLYCTK mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 8:106,795,461...106,802,675
Ensembl chr 8:106,797,343...106,802,397
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G |
Gna13 |
G protein subunit alpha 13 |
affects expression |
ISO |
Diclofenac affects the expression of GNA13 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774
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G |
Gnaq |
G protein subunit alpha q |
affects expression |
ISO |
Diclofenac affects the expression of GNAQ mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
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G |
Gnas |
GNAS complex locus |
affects expression |
ISO |
Diclofenac affects the expression of GNAS mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
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G |
Gnat1 |
G protein subunit alpha transducin 1 |
increases expression |
ISO |
Diclofenac results in increased expression of GNAT1 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 8:108,350,935...108,355,671
Ensembl chr 8:108,350,935...108,355,671
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G |
Gnb5 |
G protein subunit beta 5 |
affects expression |
ISO |
Diclofenac affects the expression of GNB5 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 8:76,076,120...76,105,069
Ensembl chr 8:76,073,306...76,105,069
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G |
Gng4 |
G protein subunit gamma 4 |
affects expression |
ISO |
Diclofenac affects the expression of GNG4 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr17:86,448,708...86,497,560
Ensembl chr17:86,449,022...86,495,254
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
affects expression increases secretion |
ISO |
Diclofenac affects the expression of GOT1 mRNA Diclofenac results in increased secretion of GOT1 protein |
CTD |
PMID:24752500 PMID:36442613 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gpd1 |
glycerol-3-phosphate dehydrogenase 1 |
multiple interactions |
EXP |
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of GPD1 protein] |
CTD |
PMID:25772430 |
|
NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
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G |
Gpld1 |
glycosylphosphatidylinositol specific phospholipase D1 |
affects expression |
ISO |
Diclofenac affects the expression of GPLD1 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939
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G |
Gpr176 |
G protein-coupled receptor 176 |
decreases expression |
ISO |
Diclofenac results in decreased expression of GPR176 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr 3:105,236,794...105,337,664
Ensembl chr 3:105,236,795...105,337,226
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G |
Gpr20 |
G protein-coupled receptor 20 |
decreases expression |
EXP |
Diclofenac results in decreased expression of GPR20 mRNA |
CTD |
PMID:30723492 |
|
NCBI chr 7:105,601,761...105,611,959
Ensembl chr 7:105,602,368...105,603,430
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions increases secretion increases expression increases activity |
EXP ISO |
[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GPT protein; Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]; Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]] Diclofenac results in increased secretion of GPT protein Diclofenac results in increased expression of GPT protein Diclofenac results in increased activity of GPT protein eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein] |
CTD |
PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 PMID:30925002 PMID:31813902 PMID:36442613 More...
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpt2 |
glutamic--pyruvic transaminase 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of GPT2 mRNA |
CTD |
PMID:35537566 |
|
NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression |
EXP ISO |
Diclofenac results in increased expression of GPX1 mRNA; Diclofenac results in increased expression of GPX1 protein |
CTD |
PMID:25772430 PMID:29027214 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx2 |
glutathione peroxidase 2 |
affects expression |
ISO |
Diclofenac affects the expression of GPX2 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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G |
Grb10 |
growth factor receptor bound protein 10 |
affects expression |
ISO |
Diclofenac affects the expression of GRB10 mRNA |
CTD |
PMID:24752500 |
|
NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806
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G |
Grid2 |
glutamate ionotropic receptor delta type subunit 2 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of GRID2 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 4:92,415,019...93,892,472
Ensembl chr 4:92,415,230...93,889,355
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G |
Grm7 |
glutamate metabotropic receptor 7 |
increases expression |
ISO |
Diclofenac results in increased expression of GRM7 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 4:143,730,862...144,613,230
Ensembl chr 4:143,731,259...144,612,344
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G |
Gsdmd |
gasdermin D |
increases cleavage multiple interactions |
EXP |
Diclofenac results in increased cleavage of GSDMD protein diacerein inhibits the reaction [Diclofenac results in increased cleavage of GSDMD protein] |
CTD |
PMID:38582345 |
|
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
affects expression |
ISO |
Diclofenac affects the expression of GSK3B mRNA |
CTD |
PMID:24752500 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsn |
gelsolin |
decreases expression |
ISO |
Diclofenac results in decreased expression of GSN mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
decreases activity |
ISO |
Diclofenac results in decreased activity of GSTA1 protein |
CTD |
PMID:27183920 |
|
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gsta4 |
glutathione S-transferase alpha 4 |
decreases activity |
ISO |
Diclofenac results in decreased activity of GSTA4 protein |
CTD |
PMID:27183920 |
|
NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
multiple interactions increases expression |
EXP |
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GSTA5 protein Diclofenac results in increased expression of GSTA5 protein |
CTD |
PMID:25772430 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Gstm1 |
glutathione S-transferase mu 1 |
decreases activity decreases expression |
ISO |
Diclofenac results in decreased activity of GSTM1 protein Diclofenac results in decreased expression of GSTM1 mRNA |
CTD |
PMID:26934552 PMID:27183920 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstm2 |
glutathione S-transferase mu 2 |
decreases activity |
ISO |
Diclofenac results in decreased activity of GSTM2 protein |
CTD |
PMID:27183920 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstm4 |
glutathione S-transferase mu 4 |
affects activity |
ISO |
Diclofenac affects the activity of GSTM4 protein |
CTD |
PMID:27183920 |
|
NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
increases expression |
ISO |
Diclofenac results in increased expression of GSTM3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions affects activity affects metabolic processing |
ISO |
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac Diclofenac affects the activity of GSTP1 protein GSTP1 protein affects the metabolism of Diclofenac metabolite; GSTP1 protein polymorphism affects the metabolism of Diclofenac metabolite |
CTD |
PMID:24185126 PMID:24246759 PMID:27183920 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gstt1 |
glutathione S-transferase theta 1 |
affects expression affects activity |
ISO |
Diclofenac affects the expression of GSTT1 mRNA Diclofenac affects the activity of GSTT1 protein |
CTD |
PMID:24752500 PMID:27183920 |
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NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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G |
Gtf2h4 |
general transcription factor 2H subunit 4 |
affects expression |
ISO |
Diclofenac affects the expression of GTF2H4 mRNA |
CTD |
PMID:24752500 |
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NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984
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G |
Gtf2h5 |
general transcription factor IIH subunit 5 |
affects expression |
ISO |
Diclofenac affects the expression of GTF2H5 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939
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G |
Gtpbp2 |
GTP binding protein 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of GTPBP2 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241
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G |
H2ax |
H2A.X variant histone |
increases expression |
ISO |
Diclofenac results in increased expression of H2AX protein |
CTD |
PMID:32087850 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hamp |
hepcidin antimicrobial peptide |
affects expression decreases secretion |
ISO |
Diclofenac affects the expression of HAMP mRNA Diclofenac results in decreased secretion of HAMP protein |
CTD |
PMID:24038040 PMID:26934552 |
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NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Hat1 |
histone acetyltransferase 1 |
affects expression |
ISO |
Diclofenac affects the expression of HAT1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
increases expression multiple interactions increases secretion |
ISO EXP |
Diclofenac results in increased expression of HAVCR1 mRNA diacerein inhibits the reaction [Diclofenac results in increased secretion of HAVCR1 protein] |
CTD |
PMID:23506792 PMID:38582345 |
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NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hba-a2 |
hemoglobin alpha, adult chain 2 |
increases expression |
EXP |
Diclofenac results in increased expression of HBA-A2 protein |
CTD |
PMID:14565772 |
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NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
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G |
Hbb |
hemoglobin subunit beta |
increases expression |
EXP |
Diclofenac results in increased expression of HBB protein |
CTD |
PMID:14565772 |
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NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
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G |
Hbegf |
heparin-binding EGF-like growth factor |
affects expression decreases expression increases expression |
ISO |
Diclofenac affects the expression of HBEGF mRNA Diclofenac results in decreased expression of HBEGF mRNA Diclofenac results in increased expression of HBEGF mRNA |
CTD |
PMID:24752500 PMID:26934552 PMID:35537566 |
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NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
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G |
Hck |
HCK proto-oncogene, Src family tyrosine kinase |
increases expression |
ISO |
Diclofenac results in increased expression of HCK mRNA |
CTD |
PMID:26934552 |
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NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
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G |
Herc6 |
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
decreases expression increases expression |
ISO |
Diclofenac results in decreased expression of HERC6 mRNA Diclofenac results in increased expression of HERC6 mRNA |
CTD |
PMID:19192274 PMID:26934552 |
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NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
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G |
Herpud1 |
homocysteine inducible ER protein with ubiquitin like domain 1 |
affects expression decreases expression |
ISO |
Diclofenac affects the expression of HERPUD1 mRNA Diclofenac results in decreased expression of HERPUD1 mRNA |
CTD |
PMID:24752500 PMID:26934552 PMID:35537566 |
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NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
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G |
Hes6 |
hes family bHLH transcription factor 6 |
decreases expression |
ISO |
Diclofenac results in decreased expression of HES6 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559
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G |
Hhex |
hematopoietically expressed homeobox |
decreases expression |
ISO |
Diclofenac results in decreased expression of HHEX mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression |
ISO |
Diclofenac results in decreased expression of HIF1A protein |
CTD |
PMID:12912967 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hist1h2bc |
histone cluster 1, H2bc |
decreases expression |
ISO |
Diclofenac results in decreased expression of H2BC21 mRNA |
CTD |
PMID:26934552 |
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NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642
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G |
Hk1 |
hexokinase 1 |
increases expression |
ISO |
Diclofenac results in increased expression of HK1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions increases expression affects expression |
EXP ISO |
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein] Diclofenac results in increased expression of HMGB1 mRNA; Diclofenac results in increased expression of HMGB1 protein Diclofenac affects the expression of HMGB1 mRNA |
CTD |
PMID:23939143 PMID:24747151 PMID:24752500 PMID:26934552 |
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NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of HMGCS2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions decreases expression increases expression affects expression |
ISO EXP |
1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA] Diclofenac results in decreased expression of HMOX1 protein Diclofenac results in increased expression of HMOX1 mRNA; Diclofenac results in increased expression of HMOX1 protein Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein] Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; diacerein inhibits the reaction [Diclofenac results in decreased expression of HMOX1 protein]; Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA]; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] Diclofenac affects the expression of HMOX1 protein |
CTD |
PMID:12763371 PMID:18172885 PMID:18227147 PMID:19022234 PMID:19952508 PMID:23939143 PMID:27313093 PMID:29027214 PMID:38582345 More...
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hmx3 |
H6 family homeobox 3 |
decreases expression |
ISO |
Diclofenac results in decreased expression of HMX3 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 1:186,313,237...186,315,201
Ensembl chr 1:186,313,063...186,315,201
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G |
Hnf1a |
HNF1 homeobox A |
affects expression |
ISO |
Diclofenac affects the expression of HNF1A mRNA |
CTD |
PMID:24752500 |
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NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
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G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
decreases expression |
EXP |
Diclofenac results in decreased expression of HNF4A mRNA |
CTD |
PMID:19022234 |
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NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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G |
Hnrnpd |
heterogeneous nuclear ribonucleoprotein D |
affects expression |
ISO |
Diclofenac affects the expression of HNRNPD mRNA |
CTD |
PMID:24752500 |
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NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
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G |
Hoatz |
HOATZ cilia and flagella associated protein |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HOATZ mRNA |
CTD |
PMID:37844793 |
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NCBI chr 8:51,385,931...51,409,796
Ensembl chr 8:51,388,382...51,412,514
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G |
Hp |
haptoglobin |
decreases expression increases expression |
ISO |
Diclofenac results in decreased expression of HP mRNA Diclofenac results in increased expression of HP mRNA |
CTD |
PMID:26934552 |
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NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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G |
Hpgd |
15-hydroxyprostaglandin dehydrogenase |
increases activity multiple interactions increases expression |
ISO |
Diclofenac results in increased activity of HPGD protein [Diclofenac co-treated with NAD] binds to HPGD protein Diclofenac results in increased expression of HPGD mRNA |
CTD |
PMID:19501039 PMID:25526675 |
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NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
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G |
Hras |
HRas proto-oncogene, GTPase |
affects expression |
ISO |
Diclofenac affects the expression of HRAS mRNA |
CTD |
PMID:24752500 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hs3st3b1 |
heparan sulfate-glucosamine 3-sulfotransferase 3B1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of HS3ST3B1 mRNA |
CTD |
PMID:35537566 |
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NCBI chr10:48,561,473...48,593,970
Ensembl chr10:48,561,473...48,593,970
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G |
Hs6st2 |
heparan sulfate 6-O-sulfotransferase 2 |
increases expression |
ISO |
Diclofenac results in increased expression of HS6ST2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr X:130,966,547...131,261,629
Ensembl chr X:130,968,385...131,261,492
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of HSD3B2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
Diclofenac results in increased activity of HSF1 protein |
CTD |
PMID:34170685 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
multiple interactions |
EXP |
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA] |
CTD |
PMID:23939143 |
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NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
multiple interactions increases expression affects expression |
EXP ISO |
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA1A mRNA] [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HSPA1A mRNA Diclofenac results in increased expression of HSPA1A mRNA Diclofenac affects the expression of HSPA1A mRNA |
CTD |
PMID:19022234 PMID:23939143 PMID:25014874 PMID:26934552 PMID:37844793 |
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NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression multiple interactions |
ISO |
Diclofenac results in increased expression of HSPA1B mRNA [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HSPA1B mRNA |
CTD |
PMID:26934552 PMID:37844793 |
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NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
EXP ISO |
Diclofenac results in increased expression of HSPA5 mRNA [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HSPA5 protein |
CTD |
PMID:25014874 PMID:25772430 PMID:27313093 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
multiple interactions increases expression |
EXP ISO |
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA8 mRNA] Diclofenac results in increased expression of HSPA8 mRNA |
CTD |
PMID:23939143 PMID:26934552 |
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NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of HSPB1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Hspb8 |
heat shock protein family B (small) member 8 |
increases expression |
ISO |
Diclofenac results in increased expression of HSPB8 mRNA |
CTD |
PMID:26934552 |
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NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
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G |
Iars1 |
isoleucyl-tRNA synthetase 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IARS1 mRNA |
CTD |
PMID:35537566 |
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NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
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G |
Ibtk |
inhibitor of Bruton tyrosine kinase |
increases expression |
ISO |
Diclofenac results in increased expression of IBTK mRNA |
CTD |
PMID:26934552 |
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NCBI chr 8:86,625,591...86,698,661
Ensembl chr 8:86,625,597...86,698,260
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions decreases expression increases expression affects expression |
EXP ISO |
Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein] Diclofenac results in decreased expression of ICAM1 mRNA Diclofenac results in increased expression of ICAM1 mRNA Diclofenac affects the expression of ICAM1 mRNA |
CTD |
PMID:14716214 PMID:18460984 PMID:24752500 PMID:26934552 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id2 |
inhibitor of DNA binding 2 |
increases expression |
ISO |
Diclofenac results in increased expression of ID2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Id3 |
inhibitor of DNA binding 3 |
increases expression |
ISO |
Diclofenac results in increased expression of ID3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IDH2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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G |
Ier3 |
immediate early response 3 |
increases expression |
ISO |
Diclofenac results in increased expression of IER3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
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G |
Ifi27 |
interferon, alpha-inducible protein 27 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IFI27 mRNA |
CTD |
PMID:19192274 |
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NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
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G |
Ifi35 |
interferon-induced protein 35 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IFI35 mRNA |
CTD |
PMID:19192274 |
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NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
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G |
Ifi44 |
interferon-induced protein 44 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IFI44 mRNA |
CTD |
PMID:19192274 PMID:35537566 |
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NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
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G |
Ifi44l |
interferon-induced protein 44-like |
decreases expression |
ISO |
Diclofenac results in decreased expression of IFI44L mRNA |
CTD |
PMID:19192274 |
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NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
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G |
Ifih1 |
interferon induced with helicase C domain 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IFIH1 mRNA |
CTD |
PMID:19192274 |
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NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
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G |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IFIT3 mRNA |
CTD |
PMID:19192274 |
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NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
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G |
Ifitm2 |
interferon induced transmembrane protein 2 |
increases expression |
ISO |
Diclofenac results in increased expression of IFITM2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741
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G |
Ifitm3 |
interferon induced transmembrane protein 3 |
increases expression |
ISO |
Diclofenac results in increased expression of IFITM3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
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G |
Ifng |
interferon gamma |
multiple interactions decreases expression |
EXP ISO |
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein] Diclofenac results in decreased expression of IFNG mRNA |
CTD |
PMID:19393675 PMID:22285467 PMID:23395999 PMID:23939143 PMID:26609140 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifrd1 |
interferon-related developmental regulator 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IFRD1 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
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G |
Igf1r |
insulin-like growth factor 1 receptor |
affects expression |
ISO |
Diclofenac affects the expression of IGF1R mRNA |
CTD |
PMID:24752500 |
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NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G |
Igf2r |
insulin-like growth factor 2 receptor |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of IGF2R mRNA |
CTD |
PMID:37844793 |
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NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
affects expression increases expression |
ISO |
Diclofenac affects the expression of IGFBP1 mRNA Diclofenac results in increased expression of IGFBP1 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
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NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Igfbp2 |
insulin-like growth factor binding protein 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IGFBP2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
affects expression |
ISO |
Diclofenac affects the expression of IGFBP3 mRNA |
CTD |
PMID:24752500 |
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NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
EXP |
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:25935278 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Ikbke |
inhibitor of nuclear factor kappa B kinase subunit epsilon |
increases expression |
ISO |
Diclofenac results in increased expression of IKBKE mRNA |
CTD |
PMID:26934552 |
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NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
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G |
Ikbkg |
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
affects expression |
ISO |
Diclofenac affects the expression of IKBKG mRNA |
CTD |
PMID:24752500 |
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NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
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G |
Il10 |
interleukin 10 |
increases response to substance multiple interactions |
ISO EXP |
IL10 gene polymorphism results in increased susceptibility to Diclofenac [Gum Arabic co-treated with Water deficiency co-treated with Diclofenac] results in increased expression of IL10 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein] |
CTD |
PMID:15122773 PMID:23939143 PMID:31042592 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12rb1 |
interleukin 12 receptor subunit beta 1 |
increases expression |
EXP |
Diclofenac results in increased expression of IL12RB1 mRNA |
CTD |
PMID:30723492 |
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NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769
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G |
Il13ra1 |
interleukin 13 receptor subunit alpha 1 |
increases expression |
ISO |
Diclofenac results in increased expression of IL13RA1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681 Ensembl chr11:115,348,860...115,408,681
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G |
Il16 |
interleukin 16 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IL16 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
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G |
Il17a |
interleukin 17A |
increases expression multiple interactions |
ISO EXP |
Diclofenac results in increased expression of IL17A protein Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein] |
CTD |
PMID:22285467 PMID:25450234 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
multiple interactions increases expression |
EXP |
diacerein inhibits the reaction [Diclofenac results in increased expression of IL18 protein] |
CTD |
PMID:38582345 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il18bp |
interleukin 18 binding protein |
increases expression |
ISO |
Diclofenac results in increased expression of IL18BP mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963
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G |
Il1a |
interleukin 1 alpha |
multiple interactions increases expression |
ISO |
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac Diclofenac results in increased expression of IL1A mRNA |
CTD |
PMID:19362101 PMID:32816093 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO EXP |
Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein] Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein] Diclofenac results in increased expression of IL1B mRNA Diclofenac results in increased expression of IL1B mRNA; Diclofenac results in increased expression of IL1B protein 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; diacerein inhibits the reaction [Diclofenac results in increased expression of IL1B protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]] |
CTD |
PMID:15135310 PMID:15705740 PMID:19393675 PMID:22285467 PMID:23395999 PMID:23939143 PMID:24747151 PMID:25051504 PMID:25450234 PMID:25935278 PMID:28138970 PMID:29027214 PMID:31042592 PMID:31926916 PMID:32816093 PMID:38582345 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1r1 |
interleukin 1 receptor type 1 |
affects expression increases expression |
ISO |
Diclofenac affects the expression of IL1R1 mRNA Diclofenac results in increased expression of IL1R1 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
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NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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G |
Il1r2 |
interleukin 1 receptor type 2 |
increases expression |
ISO EXP |
Diclofenac results in increased expression of IL1R2 mRNA |
CTD |
PMID:26934552 PMID:30723492 |
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NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
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G |
Il1rn |
interleukin 1 receptor antagonist |
increases expression decreases expression increases secretion multiple interactions |
ISO |
Diclofenac results in increased expression of IL1RN mRNA Diclofenac results in decreased expression of IL1RN mRNA Diclofenac results in increased secretion of IL1RN protein Lipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein] |
CTD |
PMID:9491209 PMID:26934552 PMID:35537566 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] |
CTD |
PMID:29777833 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il23a |
interleukin 23 subunit alpha |
decreases expression |
ISO |
Diclofenac results in decreased expression of IL23A mRNA |
CTD |
PMID:19192274 |
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NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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G |
Il24 |
interleukin 24 |
increases expression |
ISO |
Diclofenac results in increased expression of IL24 mRNA |
CTD |
PMID:32816093 |
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NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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G |
Il2rg |
interleukin 2 receptor subunit gamma |
increases expression |
ISO |
Diclofenac results in increased expression of IL2RG mRNA |
CTD |
PMID:26934552 |
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NCBI chr X:66,395,330...66,399,026
Ensembl chr X:66,392,542...66,399,823
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G |
Il33 |
interleukin 33 |
increases expression decreases expression |
ISO |
Diclofenac results in increased expression of IL33 mRNA Diclofenac results in decreased expression of IL33 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Il4 |
interleukin 4 |
increases response to substance |
ISO |
IL4 gene polymorphism results in increased susceptibility to Diclofenac |
CTD |
PMID:15122773 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein] |
CTD |
PMID:15663561 |
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NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression decreases expression |
ISO EXP |
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]; Diclofenac inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Diclofenac results in increased expression of IL6 protein] Diclofenac results in increased expression of IL6 mRNA Diclofenac results in decreased expression of IL6 mRNA; Diclofenac results in decreased expression of IL6 protein Diclofenac results in increased expression of IL6 mRNA; Diclofenac results in increased expression of IL6 protein Diclofenac inhibits the reaction [Carrageenan results in increased expression of IL6 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein] |
CTD |
PMID:19192274 PMID:19362101 PMID:23506792 PMID:23939143 PMID:24412305 PMID:25450234 PMID:25935278 PMID:27671914 PMID:29777833 PMID:31048000 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Immt |
inner membrane mitochondrial protein |
affects expression |
ISO |
Diclofenac affects the expression of IMMT mRNA |
CTD |
PMID:26934552 |
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NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109
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G |
Inhbb |
inhibin subunit beta B |
increases expression |
ISO EXP |
Diclofenac results in increased expression of INHBB mRNA |
CTD |
PMID:26934552 PMID:30723492 |
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NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832
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G |
Inka2 |
inka box actin regulator 2 |
increases expression |
ISO |
Diclofenac results in increased expression of FAM212B mRNA |
CTD |
PMID:35537566 |
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NCBI chr 2:193,185,275...193,200,643
Ensembl chr 2:193,185,275...193,200,642
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G |
Inmt |
indolethylamine N-methyltransferase |
decreases expression |
ISO |
Diclofenac results in decreased expression of INMT mRNA |
CTD |
PMID:26934552 |
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NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
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G |
Insl3 |
insulin-like 3 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of INSL3 mRNA |
CTD |
PMID:37844793 |
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NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
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G |
Insl6 |
insulin-like 6 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of INSL6 mRNA |
CTD |
PMID:37844793 |
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NCBI chr 1:227,069,958...227,073,493
Ensembl chr 1:227,069,958...227,073,493
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G |
Insr |
insulin receptor |
affects expression |
ISO |
Diclofenac affects the expression of INSR mRNA |
CTD |
PMID:24752500 |
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NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Iqcf1 |
IQ motif containing F1 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of IQCF1 mRNA |
CTD |
PMID:37844793 |
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NCBI chr 8:107,129,462...107,133,242
Ensembl chr 8:107,130,704...107,133,249
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G |
Irak4 |
interleukin-1 receptor-associated kinase 4 |
increases expression |
ISO |
Diclofenac results in increased expression of IRAK4 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837
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G |
Irf7 |
interferon regulatory factor 7 |
decreases expression |
ISO |
Diclofenac results in decreased expression of IRF7 mRNA |
CTD |
PMID:19192274 |
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NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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G |
Irgm |
immunity-related GTPase M |
increases expression |
ISO |
Diclofenac results in increased expression of IRGM1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
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G |
Irs1 |
insulin receptor substrate 1 |
affects expression |
ISO |
Diclofenac affects the expression of IRS1 mRNA |
CTD |
PMID:24752500 PMID:26934552 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Isg15 |
ISG15 ubiquitin-like modifier |
decreases expression |
ISO |
Diclofenac results in decreased expression of ISG15 mRNA |
CTD |
PMID:19192274 |
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NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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G |
Isg20 |
interferon stimulated exonuclease gene 20 |
decreases expression |
ISO |
Diclofenac results in decreased expression of ISG20 mRNA |
CTD |
PMID:19192274 |
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NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
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G |
Isyna1 |
inositol-3-phosphate synthase 1 |
increases expression |
ISO |
Diclofenac results in increased expression of ISYNA1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979
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G |
Itga2 |
integrin subunit alpha 2 |
affects expression |
ISO |
Diclofenac affects the expression of ITGA2 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
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G |
Itgal |
integrin subunit alpha L |
increases expression |
ISO |
Diclofenac results in increased expression of ITGAL mRNA |
CTD |
PMID:26934552 |
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NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
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G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
Diclofenac results in increased expression of ITGAM mRNA |
CTD |
PMID:27671914 |
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NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Itgax |
integrin subunit alpha X |
decreases expression |
ISO |
Diclofenac results in decreased expression of ITGAX mRNA |
CTD |
PMID:35537566 |
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NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
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G |
Itgb1 |
integrin subunit beta 1 |
affects expression |
ISO |
Diclofenac affects the expression of ITGB1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgb2 |
integrin subunit beta 2 |
increases expression |
ISO |
Diclofenac results in increased expression of ITGB2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
ISO |
Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein] |
CTD |
PMID:19691487 |
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NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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Itih3 |
inter-alpha trypsin inhibitor, heavy chain 3 |
increases expression |
ISO |
Diclofenac results in increased expression of ITIH3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
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Itih4 |
inter-alpha-trypsin inhibitor heavy chain 4 |
increases expression |
ISO |
Diclofenac results in increased expression of ITIH4 mRNA |
CTD |
PMID:26934552 |
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NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
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Itm2a |
integral membrane protein 2A |
increases expression |
ISO |
Diclofenac results in increased expression of ITM2A mRNA |
CTD |
PMID:17379860 |
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NCBI chr X:72,486,383...72,492,344
Ensembl chr X:72,486,381...72,492,363
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G |
Jade2 |
jade family PHD finger 2 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of JADE2 mRNA |
CTD |
PMID:37844793 |
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NCBI chr10:36,075,239...36,124,210
Ensembl chr10:36,078,917...36,116,984
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G |
Jade3 |
jade family PHD finger 3 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of JADE3 mRNA |
CTD |
PMID:37844793 |
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NCBI chr X:1,668,873...1,848,781
Ensembl chr X:1,669,930...1,845,138
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G |
Jdp2 |
Jun dimerization protein 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of JDP2 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
affects expression increases expression |
ISO |
Diclofenac affects the expression of JUN mRNA Diclofenac results in increased expression of JUN mRNA |
CTD |
PMID:24752500 PMID:26934552 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of JUNB mRNA |
CTD |
PMID:37844793 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO EXP |
Diclofenac results in increased expression of JUND mRNA |
CTD |
PMID:19022234 |
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NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Kat6b |
lysine acetyltransferase 6B |
affects expression |
ISO |
Diclofenac affects the expression of KAT6B mRNA |
CTD |
PMID:24752500 |
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NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316
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G |
Kbtbd11 |
kelch repeat and BTB domain containing 11 |
increases expression |
EXP |
Diclofenac results in increased expression of KBTBD11 mRNA |
CTD |
PMID:30723492 |
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NCBI chr16:74,618,291...74,638,010
Ensembl chr16:74,615,792...74,637,736
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G |
Khdc3 |
KH domain containing 3, subcortical maternal complex member |
increases expression |
EXP |
Diclofenac results in increased expression of KHDC3 mRNA |
CTD |
PMID:30723492 |
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NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248
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G |
Kif5c |
kinesin family member 5C |
increases expression |
EXP |
Diclofenac results in increased expression of KIF5C mRNA |
CTD |
PMID:30723492 |
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NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
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G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of KIT mRNA |
CTD |
PMID:37844793 |
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NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
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G |
Klf4 |
KLF transcription factor 4 |
decreases expression |
ISO |
Diclofenac results in decreased expression of KLF4 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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G |
Klhl33 |
kelch-like family member 33 |
decreases expression |
ISO |
Diclofenac results in decreased expression of KLHL33 mRNA |
CTD |
PMID:35537566 |
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NCBI chr15:24,105,923...24,114,445
Ensembl chr15:24,105,930...24,114,438
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G |
Klk1 |
kallikrein 1 |
increases expression |
ISO |
Diclofenac results in increased expression of KLK1 protein |
CTD |
PMID:23506792 |
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NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754
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G |
Kndc1 |
kinase non-catalytic C-lobe domain containing 1 |
increases expression |
EXP |
Diclofenac results in increased expression of KNDC1 mRNA |
CTD |
PMID:30723492 |
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NCBI chr 1:194,689,962...194,738,353
Ensembl chr 1:194,690,135...194,738,362
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Kng1 |
kininogen 1 |
increases expression multiple interactions |
EXP |
Diclofenac results in increased expression of KNG1 protein [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of KNG1 protein; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in increased expression of KNG1 protein] |
CTD |
PMID:25772430 |
|
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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G |
Kras |
KRAS proto-oncogene, GTPase |
affects expression |
ISO |
Diclofenac affects the expression of KRAS mRNA |
CTD |
PMID:24752500 |
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NCBI chr 4:178,185,418...178,218,484
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G |
Lax1 |
lymphocyte transmembrane adaptor 1 |
decreases expression |
ISO |
Diclofenac results in decreased expression of LAX1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr13:45,134,825...45,145,381
Ensembl chr13:45,134,834...45,145,381
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G |
Lbp |
lipopolysaccharide binding protein |
increases expression decreases expression affects expression |
ISO |
Diclofenac results in increased expression of LBP protein Diclofenac results in decreased expression of LBP mRNA Diclofenac affects the expression of LBP mRNA |
CTD |
PMID:26934552 |
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NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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G |
Lcn2 |
lipocalin 2 |
increases expression increases secretion multiple interactions |
EXP ISO |
Diclofenac results in increased expression of LCN2 mRNA Diclofenac results in increased secretion of LCN2 protein diacerein inhibits the reaction [Diclofenac results in increased secretion of LCN2 protein]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA] |
CTD |
PMID:23939143 PMID:26934552 PMID:38582345 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lcp2 |
lymphocyte cytosolic protein 2 |
increases expression |
ISO |
Diclofenac results in increased expression of LCP2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559
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G |
Ldha |
lactate dehydrogenase A |
increases expression |
EXP |
Diclofenac results in increased expression of LDHA protein |
CTD |
PMID:25772430 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Leap2 |
liver enriched antimicrobial peptide 2 |
increases expression |
ISO |
Diclofenac results in increased expression of LEAP2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244
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G |
Lepr |
leptin receptor |
affects expression increases expression |
ISO |
Diclofenac affects the expression of LEPR mRNA Diclofenac results in increased expression of LEPR protein |
CTD |
PMID:26934552 |
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NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Lgals3 |
galectin 3 |
increases expression |
ISO |
Diclofenac results in increased expression of LGALS3 mRNA |
CTD |
PMID:26934552 |
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NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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G |
Lgmn |
legumain |
increases expression |
ISO |
Diclofenac results in increased expression of LGMN mRNA |
CTD |
PMID:26934552 |
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NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
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G |
Lgr4 |
leucine-rich repeat-containing G protein-coupled receptor 4 |
increases expression |
ISO |
Diclofenac results in increased expression of LGR4 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899
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G |
Lhx2 |
LIM homeobox 2 |
decreases expression |
ISO |
Diclofenac results in decreased expression of LHX2 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908
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G |
Lifr |
LIF receptor subunit alpha |
decreases expression |
ISO |
Diclofenac results in decreased expression of LIFR mRNA |
CTD |
PMID:26934552 |
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NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
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G |
Lipc |
lipase C, hepatic type |
decreases expression |
ISO |
Diclofenac results in decreased expression of LIPC mRNA |
CTD |
PMID:26934552 |
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NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
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G |
Litaf |
lipopolysaccharide-induced TNF factor |
increases expression |
ISO |
Diclofenac results in increased expression of LITAF mRNA |
CTD |
PMID:26934552 |
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NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
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G |
Lmnb1 |
lamin B1 |
increases expression |
ISO |
Diclofenac results in increased expression of LMNB1 mRNA |
CTD |
PMID:35537566 |
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NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
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G |
Lmo4 |
LIM domain only 4 |
decreases expression |
ISO |
Diclofenac results in decreased expression of LMO4 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880
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G |
Lpar4 |
lysophosphatidic acid receptor 4 |
decreases expression |
ISO |
Diclofenac results in decreased expression of LPAR4 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr X:72,033,486...72,046,978
Ensembl chr X:72,033,486...72,046,977
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G |
Lpl |
lipoprotein lipase |
increases expression |
ISO |
Diclofenac results in increased expression of LPL mRNA |
CTD |
PMID:26934552 |
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Lrg1 |
leucine-rich alpha-2-glycoprotein 1 |
increases expression |
ISO |
Diclofenac results in increased expression of LRG1 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813
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G |
Lrp8 |
LDL receptor related protein 8 |
increases expression |
ISO |
Diclofenac results in increased expression of LRP8 mRNA |
CTD |
PMID:35537566 |
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NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352
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G |
Ltc4s |
leukotriene C4 synthase |
increases expression |
EXP |
Diclofenac results in increased expression of LTC4S mRNA |
CTD |
PMID:30723492 |
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NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
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G |
Lxn |
latexin |
increases expression |
ISO |
Diclofenac results in increased expression of LXN mRNA |
CTD |
PMID:19192274 |
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NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460
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G |
Ly6e |
lymphocyte antigen 6 family member E |
decreases expression increases expression |
ISO |
Diclofenac results in decreased expression of LY6E mRNA Diclofenac results in increased expression of LY6E mRNA |
CTD |
PMID:19192274 PMID:26934552 |
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NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
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G |
Ly75 |
lymphocyte antigen 75 |
increases expression |
ISO |
Diclofenac results in increased expression of LY75 mRNA |
CTD |
PMID:26934552 |
|
NCBI chr 3:44,764,702...44,852,219
Ensembl chr 3:44,765,122...44,852,374
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G |
Lyz2 |
lysozyme 2 |
increases expression |
ISO |
Diclofenac results in increased expression of LYZ2 mRNA |
CTD |
PMID:26934552 |
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NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
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G |
Magi1 |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
affects expression |
ISO |
Diclofenac affects the expression of MAGI1 mRNA |
CTD |
PMID:24752500 |
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NCBI chr 4:126,205,663...126,811,354
Ensembl chr 4:126,206,816...126,811,691
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G |
Malsu1 |
mitochondrial assembly of ribosomal large subunit 1 |
multiple interactions |
ISO |
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MALSU1 mRNA |
CTD |
PMID:37844793 |
|
NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905
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G |
Maoa |
monoamine oxidase A |
affects expression |
ISO |
Diclofenac affects the expression of MAOA mRNA |
CTD |
PMID:24752500 |
|
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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G |
Maob |
monoamine oxidase B |
affects expression |
ISO |
Diclofenac affects the expression of MAOB mRNA |
CTD |
PMID:24752500 |
|
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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G |
Map2k3 |
mitogen activated protein kinase kinase 3 |
affects expression |
ISO |
Diclofenac affects the expression of MAP2K3 mRNA |
CTD |
PMID:24752500 |
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NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
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G |
Map2k5 |
mitogen activated protein kinase kinase 5 |
affects expression |
ISO |
Diclofenac affects the expression of MAP2K5 mRNA |
CTD |
PMID:24752500 |
|
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