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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bridged diphenyl antifungal agent
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Accession:CHEBI:60644 term browser browse the term
Definition:Any organic aromatic compound containing two phenyl (or substituted phenyl) groups attached to a single carbon or heteroatom and which has significant antifungal properties.
Synonyms:related_synonym: bridged diphenyl antifungal agents



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4'-hydroxydiclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 4'-hydroxydiclofenac results in increased expression of CCL2 mRNA CTD PMID:24104198 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac CTD PMID:24246759 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Esr1 estrogen receptor 1 affects activity ISO 4'-hydroxydiclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases glutathionylation
multiple interactions
ISO GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]
CTD PMID:24246759 PMID:24552538 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Il10 interleukin 10 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein] CTD PMID:29777833 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il2 interleukin 2 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein] CTD PMID:29777833 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein] CTD PMID:29777833 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac CTD PMID:28754375 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac] CTD PMID:24552538 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac CTD PMID:29281794 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein CTD PMID:29777833 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Tnf tumor necrosis factor increases response to substance
multiple interactions
EXP
ISO
TNF protein results in increased susceptibility to 4'-hydroxydiclofenac
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]
CTD PMID:23939143 PMID:29777833 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
5-hydroxydiclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] CTD PMID:24246759 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] CTD PMID:24246759 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 5-hydroxydiclofenac CTD PMID:28754375 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
aceclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to aceclofenac CTD PMID:12147693 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO aceclofenac results in increased expression of GDF15 protein
aceclofenac results in increased expression of GDF15 mRNA
CTD PMID:15555568 PMID:18076062 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Sell selectin L decreases expression ISO aceclofenac results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein CTD PMID:17328244 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
bithionol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iyd iodotyrosine deiodinase multiple interactions ISO Bithionol inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bithionol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Thra thyroid hormone receptor alpha increases activity EXP Bithionol results in increased activity of THRA protein CTD PMID:22015988 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta increases activity EXP Bithionol results in increased activity of THRB protein CTD PMID:22015988 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tp53 tumor protein p53 affects activity ISO Bithionol affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
Dichlorophen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Iyd iodotyrosine deiodinase multiple interactions ISO Dichlorophen inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Tp53 tumor protein p53 affects activity ISO Dichlorophen affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO Diclofenac results in increased expression of A2M mRNA; Diclofenac results in increased expression of A2ML1 mRNA CTD PMID:26934552 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Aacs acetoacetyl-CoA synthetase decreases expression ISO Diclofenac results in decreased expression of AACS mRNA CTD PMID:26934552 NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954
JBrowse link
G Aars1 alanyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of AARS1 mRNA CTD PMID:35537566 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Diclofenac inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Diclofenac results in decreased activity of ABCB11 protein
CTD PMID:24014644 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases response to substance
decreases activity
ISO Diclofenac results in increased expression of ABCB1B mRNA
ABCB1A gene mutant form results in decreased susceptibility to Diclofenac
Diclofenac results in decreased activity of ABCB1A protein
CTD PMID:15458769 PMID:19022234 PMID:28193520 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B decreases expression EXP Diclofenac results in decreased expression of ABCB1B mRNA CTD PMID:19022234 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression
decreases activity
ISO Diclofenac results in decreased expression of ABCB4 mRNA
Diclofenac results in decreased activity of ABCB4 protein
CTD PMID:19022234 PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
increases expression
multiple interactions
ISO
EXP
Diclofenac results in decreased activity of ABCC2 protein
Diclofenac results in increased expression of ABCC2 mRNA
ABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to Diclofenac
CTD PMID:19022234 PMID:22646477 PMID:25450747 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression ISO Diclofenac affects the expression of ABCC4 mRNA CTD PMID:24752500 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase affects expression ISO Diclofenac affects the expression of ABL2 mRNA CTD PMID:24752500 NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742
JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Diclofenac results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 affects expression ISO Diclofenac affects the expression of ACIN1 mRNA CTD PMID:24752500 NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001
JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Diclofenac results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
JBrowse link
G Acot2 acyl-CoA thioesterase 2 decreases expression ISO Diclofenac results in decreased expression of ACOT2 mRNA CTD PMID:26934552 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP Diclofenac results in increased expression of ACOX1 mRNA CTD PMID:19022234 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acp3 acid phosphatase 3 increases expression ISO Diclofenac results in increased expression of ACP3 mRNA CTD PMID:26934552 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle affects expression ISO Diclofenac affects the expression of ACTA1 mRNA CTD PMID:24752500 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Actl9 actin-like 9 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of ACTL9 mRNA CTD PMID:37844793 NCBI chr 7:14,234,504...14,235,881
Ensembl chr 7:14,234,504...14,235,881
JBrowse link
G Actn1 actinin, alpha 1 affects expression EXP Diclofenac affects the expression of ACTN1 mRNA CTD PMID:19022234 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
JBrowse link
G Acvr1 activin A receptor type 1 affects expression ISO Diclofenac affects the expression of ACVR1 mRNA CTD PMID:24752500 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
JBrowse link
G Acvr1b activin A receptor type 1B affects expression
multiple interactions
ISO Diclofenac affects the expression of ACVR1B mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ACVR1B mRNA
CTD PMID:24752500 PMID:37844793 NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673
JBrowse link
G Acvr2b activin A receptor type 2B affects expression ISO Diclofenac affects the expression of ACVR2B mRNA CTD PMID:24752500 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
JBrowse link
G Adamdec1 ADAM-like, decysin 1 increases expression ISO Diclofenac results in increased expression of ADAMDEC1 mRNA CTD PMID:26934552 NCBI chr15:42,900,629...42,921,684
Ensembl chr15:42,900,636...42,921,712
JBrowse link
G Adcy6 adenylate cyclase 6 affects expression ISO Diclofenac affects the expression of ADCY6 mRNA CTD PMID:24752500 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Adcy9 adenylate cyclase 9 affects expression
decreases expression
ISO Diclofenac affects the expression of ADCY9 mRNA
Diclofenac results in decreased expression of ADCY9 mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide increases expression EXP Diclofenac results in increased expression of ADH1 protein CTD PMID:25772430 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide decreases expression ISO Diclofenac results in decreased expression of ADH7 mRNA CTD PMID:35537566 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
JBrowse link
G Adk adenosine kinase increases expression
decreases expression
ISO
EXP
Diclofenac results in increased expression of ADK mRNA
Diclofenac results in decreased expression of ADK mRNA
CTD PMID:19022234 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
JBrowse link
G Adora2a adenosine A2a receptor increases expression ISO Diclofenac results in increased expression of ADORA2A mRNA CTD PMID:26934552 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adora2b adenosine A2B receptor increases expression ISO Diclofenac results in increased expression of ADORA2B mRNA CTD PMID:26934552 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO Diclofenac results in increased expression of ADRB2 mRNA CTD PMID:26934552 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO Diclofenac results in increased expression of AEN mRNA CTD PMID:35537566 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Diclofenac results in increased expression of AGER mRNA CTD PMID:24747151 PMID:28138970 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Aggf1 angiogenic factor with G patch and FHA domains 1 affects expression ISO Diclofenac affects the expression of AGGF1 mRNA CTD PMID:24752500 NCBI chr 2:26,619,336...26,646,050
Ensembl chr 2:26,619,339...26,645,952
JBrowse link
G Ago2 argonaute RISC catalytic component 2 affects expression ISO Diclofenac affects the expression of AGO2 mRNA CTD PMID:24752500 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974
JBrowse link
G Ago3 argonaute RISC catalytic component 3 affects expression ISO Diclofenac affects the expression of AGO3 mRNA CTD PMID:24752500 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
JBrowse link
G Ago4 argonaute RISC component 4 affects expression ISO Diclofenac affects the expression of AGO4 mRNA CTD PMID:24752500 NCBI chr 5:138,780,446...138,825,898
Ensembl chr 5:138,783,069...138,825,632
JBrowse link
G Agrp agouti related neuropeptide increases expression EXP Diclofenac results in increased expression of AGRP mRNA CTD PMID:30723492 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Diclofenac results in increased expression of AHR mRNA CTD PMID:26934552 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ahsg alpha-2-HS-glycoprotein multiple interactions EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein CTD PMID:25772430 NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects expression ISO Diclofenac affects the expression of AIFM1 mRNA CTD PMID:24752500 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Aim2 absent in melanoma 2 increases expression ISO Diclofenac results in increased expression of AIM2 mRNA CTD PMID:26934552 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975
JBrowse link
G Akna AT-hook transcription factor decreases expression ISO Diclofenac results in decreased expression of AKNA mRNA CTD PMID:35537566 NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AKR1B7 mRNA CTD PMID:37844793 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects expression ISO Diclofenac affects the expression of AKT1 mRNA CTD PMID:24752500 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression ISO Diclofenac affects the expression of AKT2 mRNA CTD PMID:24752500 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ALAS1 mRNA CTD PMID:26934552 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 affects expression ISO Diclofenac affects the expression of ALAS2 mRNA CTD PMID:24752500 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G Alb albumin affects binding
decreases secretion
multiple interactions
decreases expression
increases expression
ISO
EXP
Diclofenac binds to ALB protein
Diclofenac results in decreased secretion of ALB protein
[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein]
Diclofenac results in decreased expression of ALB protein
Diclofenac results in increased expression of ALB mRNA
CTD PMID:9353694 PMID:19022234 PMID:28400101 PMID:36442613 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression
decreases expression
ISO Diclofenac results in increased expression of ALDH18A1 mRNA
Diclofenac results in decreased expression of ALDH18A1 mRNA
CTD PMID:26934552 PMID:35537566 NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Diclofenac results in increased expression of ALDH1B1 mRNA CTD PMID:26934552 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 decreases expression ISO Diclofenac results in decreased expression of ALDH1L2 mRNA CTD PMID:26934552 NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO Diclofenac results in decreased expression of ALDH3A2 mRNA CTD PMID:26934552 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression EXP Diclofenac results in increased expression of ALDOC mRNA CTD PMID:30723492 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression
multiple interactions
EXP
ISO
Diclofenac results in increased expression of ALOX15 mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ALOX15 mRNA
CTD PMID:23939143 PMID:37844793 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Amh anti-Mullerian hormone increases expression
multiple interactions
ISO Diclofenac results in increased expression of AMH mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AMH mRNA
CTD PMID:35537566 PMID:37844793 NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
JBrowse link
G Amotl2 angiomotin like 2 decreases expression ISO Diclofenac results in decreased expression of AMOTL2 mRNA CTD PMID:35537566 NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910
JBrowse link
G Ang angiogenin increases expression ISO Diclofenac results in increased expression of ANG mRNA CTD PMID:26934552 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Anxa8 annexin A8 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ANXA8 mRNA CTD PMID:37844793 NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043
JBrowse link
G Aoc3 amine oxidase, copper containing 3 decreases expression ISO Diclofenac results in decreased expression of AOC3 mRNA CTD PMID:26934552 NCBI chr10:86,272,757...86,280,702 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression ISO Diclofenac affects the expression of APAF1 mRNA CTD PMID:24752500 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apcs amyloid P component, serum multiple interactions
increases expression
EXP
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein
Diclofenac results in increased expression of APCS mRNA; Diclofenac results in increased expression of APCS protein
CTD PMID:25772430 PMID:26934552 NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Apoa4 apolipoprotein A4 affects expression ISO Diclofenac affects the expression of APOA4 mRNA CTD PMID:26934552 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Aqp2 aquaporin 2 decreases expression EXP Diclofenac results in decreased expression of AQP2 protein CTD PMID:15579502 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Aqp9 aquaporin 9 decreases expression ISO Diclofenac results in decreased expression of AQP9 mRNA CTD PMID:35537566 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Aqr aquarius intron-binding spliceosomal factor affects expression ISO Diclofenac affects the expression of AQR mRNA CTD PMID:24752500 NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044
JBrowse link
G Ar androgen receptor affects activity ISO Diclofenac affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase affects expression ISO Diclofenac affects the expression of ARAF mRNA CTD PMID:24752500 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073
JBrowse link
G Arhgap20 Rho GTPase activating protein 20 increases expression EXP Diclofenac results in increased expression of ARHGAP20 mRNA CTD PMID:30723492 NCBI chr 8:52,074,472...52,155,739
Ensembl chr 8:52,074,158...52,155,739
JBrowse link
G Arhgap26 Rho GTPase activating protein 26 affects expression ISO Diclofenac affects the expression of ARHGAP26 mRNA CTD PMID:24752500 NCBI chr18:30,835,806...31,237,945
Ensembl chr18:30,838,671...31,235,194
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 affects expression ISO Diclofenac affects the expression of ARHGEF2 mRNA CTD PMID:24752500 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 affects expression
decreases expression
ISO Diclofenac affects the expression of ARHGEF3 mRNA
Diclofenac results in decreased expression of ARHGEF3 mRNA
CTD PMID:24752500 PMID:35537566 NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 affects expression ISO Diclofenac affects the expression of ARHGEF7 mRNA CTD PMID:24752500 NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697
JBrowse link
G Arid4a AT-rich interaction domain 4A multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ARID4A mRNA CTD PMID:37844793 NCBI chr 6:89,522,459...89,593,868
Ensembl chr 6:89,522,442...89,593,510
JBrowse link
G Arid5a AT-rich interaction domain 5A decreases expression ISO Diclofenac results in decreased expression of ARID5A mRNA CTD PMID:35537566 NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597
JBrowse link
G Arid5b AT-rich interaction domain 5B decreases expression ISO Diclofenac results in decreased expression of ARID5B mRNA CTD PMID:26934552 NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433
JBrowse link
G Arl11 ADP-ribosylation factor like GTPase 11 decreases expression ISO Diclofenac results in decreased expression of ARL11 mRNA CTD PMID:35537566 NCBI chr15:35,483,330...35,485,579
Ensembl chr15:35,480,018...35,496,596
JBrowse link
G Armcx1 armadillo repeat containing, X-linked 1 increases expression EXP Diclofenac results in increased expression of ARMCX1 mRNA CTD PMID:30723492 NCBI chr  X:97,898,969...97,902,874
Ensembl chr  X:97,898,883...97,903,299
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator affects expression ISO Diclofenac affects the expression of ARNT mRNA CTD PMID:24752500 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ARRB1 mRNA CTD PMID:37844793 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Diclofenac results in increased expression of ARRDC3 mRNA CTD PMID:35537566 NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 affects expression ISO Diclofenac affects the expression of ASAP1 mRNA CTD PMID:24752500 NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754
JBrowse link
G Ash2l ASH2 like histone lysine methyltransferase complex subunit affects expression ISO Diclofenac affects the expression of ASH2L mRNA CTD PMID:24752500 NCBI chr16:66,242,205...66,264,064
Ensembl chr16:66,242,212...66,264,061
JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases expression EXP Diclofenac results in decreased expression of ASIC1 mRNA CTD PMID:11588175 NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
JBrowse link
G Asic2 acid sensing ion channel subunit 2 decreases expression EXP Diclofenac results in decreased expression of ASIC2 mRNA CTD PMID:11588175 NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424
JBrowse link
G Asic3 acid sensing ion channel subunit 3 decreases expression
decreases activity
EXP Diclofenac results in decreased expression of ASIC3 mRNA
Diclofenac results in decreased activity of ASIC3 protein
CTD PMID:11588175 NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643
JBrowse link
G Asl argininosuccinate lyase affects expression ISO Diclofenac affects the expression of ASL mRNA CTD PMID:24752500 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression
increases expression
ISO Diclofenac results in decreased expression of ASNS mRNA
Diclofenac results in increased expression of ASNS mRNA
CTD PMID:19192274 PMID:26934552 PMID:35537566 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ASS1 mRNA CTD PMID:26934552 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atf2 activating transcription factor 2 affects expression ISO Diclofenac affects the expression of ATF2 mRNA CTD PMID:24752500 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atf4 activating transcription factor 4 affects expression
decreases expression
increases expression
ISO Diclofenac affects the expression of ATF4 mRNA
Diclofenac results in decreased expression of ATF4 mRNA
Diclofenac results in increased expression of ATF4 mRNA
CTD PMID:24752500 PMID:27313093 PMID:35537566 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO Diclofenac results in decreased expression of ATF5 mRNA CTD PMID:35537566 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
JBrowse link
G Atp11a ATPase phospholipid transporting 11A increases expression ISO Diclofenac results in increased expression of ATP11A mRNA CTD PMID:26934552 NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1A protein
Diclofenac results in increased expression of ATP5F1A protein
CTD PMID:25772430 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1B protein
Diclofenac results in increased expression of ATP5F1B protein
CTD PMID:25772430 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5PF protein
Diclofenac results in increased expression of ATP5PF protein
CTD PMID:25772430 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
JBrowse link
G Azin1 antizyme inhibitor 1 affects expression ISO Diclofenac affects the expression of AZIN1 mRNA CTD PMID:24752500 NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578
JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 increases expression ISO Diclofenac results in increased expression of B3GALT1 mRNA CTD PMID:26934552 NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313
JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects expression ISO Diclofenac affects the expression of BACH1 mRNA CTD PMID:24752500 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity ISO Diclofenac results in increased activity of BAK1 protein CTD PMID:18191430 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bard1 BRCA1 associated RING domain 1 affects expression ISO Diclofenac affects the expression of BARD1 mRNA CTD PMID:24752500 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases activity
increases expression
affects localization
ISO
EXP
Diclofenac results in increased activity of BAX protein
Diclofenac results in increased expression of BAX mRNA
Diclofenac affects the localization of BAX protein
CTD PMID:18191430 PMID:29027214 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member decreases expression ISO Diclofenac results in decreased expression of BCAR3 mRNA CTD PMID:35537566 NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO
EXP
Diclofenac results in increased expression of BCL2 mRNA CTD PMID:29027214 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Diclofenac results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
affects expression
ISO Diclofenac results in increased expression of BCL2L1 mRNA alternative form
Diclofenac affects the expression of BCL2L1 mRNA
CTD PMID:14609740 PMID:24752500 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 Bcl2-like 11 affects expression ISO Diclofenac affects the expression of BCL2L11 mRNA CTD PMID:24752500 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Diclofenac results in increased expression of BCL3 mRNA CTD PMID:26934552 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Diclofenac results in decreased expression of BCL6 mRNA CTD PMID:26934552 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Diclofenac results in decreased expression of BDH1 mRNA CTD PMID:26934552 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
affects expression
increases activity
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Diclofenac results in increased activity of BID protein]
Diclofenac affects the expression of BID mRNA
CTD PMID:18191430 PMID:24752500 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Bmp4 bone morphogenetic protein 4 affects expression ISO Diclofenac affects the expression of BMP4 mRNA CTD PMID:24752500 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression
increases expression
ISO Diclofenac results in decreased expression of BMP6 mRNA
Diclofenac results in increased expression of BMP6 mRNA
CTD PMID:26934552 PMID:32816093 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase affects expression ISO Diclofenac affects the expression of BRAF mRNA CTD PMID:24752500 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO Diclofenac results in increased expression of BRCA1 mRNA CTD PMID:26934552 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of BRCA2 mRNA CTD PMID:37844793 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Brd3os BRD3 opposite strand decreases expression ISO Diclofenac results in decreased expression of BRD3OS mRNA CTD PMID:35537566 NCBI chr 3:10,770,229...10,771,860 JBrowse link
G Brdt bromodomain testis associated decreases expression ISO Diclofenac results in decreased expression of BRDT mRNA CTD PMID:35537566 NCBI chr14:2,387,372...2,445,857
Ensembl chr14:2,387,796...2,445,842
JBrowse link
G Brip1 BRCA1 interacting helicase 1 affects expression ISO Diclofenac affects the expression of BRIP1 mRNA CTD PMID:24752500 NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Diclofenac results in decreased expression of BTG1 mRNA CTD PMID:26934552 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G C1qa complement C1q A chain increases expression ISO Diclofenac results in increased expression of C1QA mRNA CTD PMID:26934552 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C1qb complement C1q B chain increases expression ISO Diclofenac results in increased expression of C1QB mRNA CTD PMID:26934552 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
JBrowse link
G C1qc complement C1q C chain increases expression ISO Diclofenac results in increased expression of C1QC mRNA CTD PMID:26934552 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G C2 complement C2 increases expression ISO Diclofenac results in increased expression of C2 mRNA CTD PMID:26934552 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G C4b complement C4B increases expression ISO Diclofenac results in increased expression of C4B mRNA CTD PMID:26934552 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B decreases expression ISO Diclofenac results in decreased expression of CACNA1B mRNA CTD PMID:26934552 NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091
JBrowse link
G Calca calcitonin-related polypeptide alpha decreases expression EXP Diclofenac results in decreased expression of CALCA mRNA CTD PMID:11588175 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Calm1 calmodulin 1 affects expression ISO Diclofenac affects the expression of CALM1 mRNA CTD PMID:24752500 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calml3 calmodulin-like 3 increases expression EXP Diclofenac results in increased expression of CALML3 mRNA CTD PMID:30723492 NCBI chr17:66,419,844...66,423,083
Ensembl chr17:66,419,882...66,423,175
JBrowse link
G Calr calreticulin affects expression
decreases expression
EXP Diclofenac affects the expression of CALR mRNA
Diclofenac results in decreased expression of CALR mRNA
CTD PMID:18246545 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO Diclofenac results in increased expression of CAMK1D mRNA CTD PMID:26934552 NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression EXP Diclofenac results in increased expression of CAMK2B mRNA CTD PMID:30723492 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO Diclofenac results in increased expression of CAMP mRNA CTD PMID:26934552 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
JBrowse link
G Capn10 calpain 10 affects expression ISO Diclofenac affects the expression of CAPN10 mRNA CTD PMID:24752500 NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494
JBrowse link
G Car1 carbonic anhydrase 1 decreases expression ISO Diclofenac results in decreased expression of CAR1 mRNA CTD PMID:26934552 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car13 carbonic anhydrase 13 decreases expression ISO Diclofenac results in decreased expression of CAR13 mRNA CTD PMID:26934552 NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525
JBrowse link
G Car3 carbonic anhydrase 3 decreases expression
increases secretion
ISO
EXP
Diclofenac results in decreased expression of CAR3 mRNA
Diclofenac results in increased secretion of CAR3 protein
CTD PMID:24038040 PMID:26934552 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of CARS1 mRNA CTD PMID:35537566 NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
JBrowse link
G Casp1 caspase 1 multiple interactions
increases cleavage
EXP diacerein inhibits the reaction [Diclofenac results in increased cleavage of CASP1 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] CTD PMID:25450234 PMID:38582345 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp2 caspase 2 multiple interactions
affects expression
ISO Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP2 protein]
Diclofenac affects the expression of CASP2 mRNA
CTD PMID:16388830 PMID:24752500 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
Diclofenac results in increased activity of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein]; Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]
CTD PMID:12826271 PMID:14599462 PMID:14609740 PMID:16388830 PMID:24770551 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 affects expression ISO Diclofenac affects the expression of CASP6 mRNA CTD PMID:24752500 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp8 caspase 8 increases activity
affects expression
multiple interactions
EXP
ISO
Diclofenac results in increased activity of CASP8 protein
Diclofenac affects the expression of CASP8 mRNA
[Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]
CTD PMID:14609740 PMID:20237495 PMID:24752500 PMID:27313093 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
ISO
EXP
[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP9 protein]
Diclofenac results in increased expression of CASP9 mRNA
CTD PMID:14609740 PMID:16388830 PMID:25014874 PMID:27313093 PMID:29027214 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases activity
decreases activity
multiple interactions
EXP
ISO
Diclofenac results in increased activity of CAT protein
Diclofenac results in decreased activity of CAT protein
Ondansetron promotes the reaction [Diclofenac results in decreased activity of CAT protein]
[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of CAT protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of CAT protein]
CTD PMID:17274466 PMID:23994749 PMID:28535741 PMID:31042592 PMID:31332906 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbl Cbl proto-oncogene affects expression ISO Diclofenac affects the expression of CBL mRNA CTD PMID:24752500 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
JBrowse link
G Cbr1 carbonyl reductase 1 affects expression ISO Diclofenac affects the expression of CBR1 mRNA CTD PMID:24752500 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Cbs cystathionine beta synthase affects expression ISO Diclofenac affects the expression of CBS mRNA CTD PMID:24752500 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Ccdc137 coiled-coil domain containing 137 increases expression ISO Diclofenac results in increased expression of CCDC137 mRNA CTD PMID:35537566 NCBI chr10:105,730,776...105,737,158
Ensembl chr10:105,730,739...105,737,158
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression
affects expression
EXP
ISO
[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein]
Diclofenac analog results in increased secretion of CCL2 protein
SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]
Diclofenac results in increased expression of CCL2 protein
Diclofenac affects the expression of CCL2 mRNA
Diclofenac results in increased expression of CCL2 mRNA
CTD PMID:22285467 PMID:23939143 PMID:24104198 PMID:25051504 PMID:27671914 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression
EXP
ISO
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]
Diclofenac results in decreased expression of CCL3 mRNA
CTD PMID:23939143 PMID:35537566 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 increases expression ISO Diclofenac results in increased expression of CCL6 mRNA CTD PMID:26934552 NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
JBrowse link
G Ccn1 cellular communication network factor 1 affects expression
increases expression
ISO Diclofenac affects the expression of CCN1 mRNA
Diclofenac results in increased expression of CCN1 mRNA
CTD PMID:19192274 PMID:24752500 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
affects expression
decreases expression
increases expression
ISO
EXP
Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
Diclofenac affects the expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 mRNA
Diclofenac results in increased expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 protein
CTD PMID:15188006 PMID:15489888 PMID:19022234 PMID:26934552 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 affects expression ISO Diclofenac affects the expression of CCND3 mRNA CTD PMID:24752500 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 affects expression ISO Diclofenac affects the expression of CCNE1 mRNA CTD PMID:24752500 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccne2 cyclin E2 affects expression ISO Diclofenac affects the expression of CCNE2 mRNA CTD PMID:24752500 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccnf cyclin F affects expression ISO Diclofenac affects the expression of CCNF mRNA CTD PMID:24752500 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
JBrowse link
G Ccng1 cyclin G1 increases expression EXP Diclofenac results in increased expression of CCNG1 mRNA CTD PMID:19022234 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Ccnh cyclin H affects expression ISO Diclofenac affects the expression of CCNH mRNA CTD PMID:24752500 NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO Diclofenac results in increased expression of CCR1 mRNA CTD PMID:26934552 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Diclofenac results in increased expression of CCR5 mRNA CTD PMID:26934552 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cd14 CD14 molecule increases expression ISO Diclofenac results in increased expression of CD14 mRNA CTD PMID:26934552 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd163 CD163 molecule increases expression ISO Diclofenac results in increased expression of CD163 mRNA CTD PMID:26934552 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Cd200r1l CD200 receptor 1-like decreases expression ISO Diclofenac results in decreased expression of CD200R4 mRNA CTD PMID:35537566 NCBI chr11:55,842,632...55,860,914
Ensembl chr11:55,842,634...55,885,680
JBrowse link
G Cd244 CD244 molecule decreases expression ISO Diclofenac results in decreased expression of CD244 mRNA CTD PMID:35537566 NCBI chr13:84,051,339...84,082,864
Ensembl chr13:84,052,493...84,074,492
JBrowse link
G Cd28 Cd28 molecule increases expression ISO Diclofenac results in increased expression of CD28 mRNA CTD PMID:26934552 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd44 CD44 molecule increases expression ISO Diclofenac results in increased expression of CD44 mRNA CTD PMID:26934552 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Diclofenac results in increased expression of CD55 mRNA CTD PMID:26934552 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cd5l Cd5 molecule-like increases expression ISO Diclofenac results in increased expression of CD5L mRNA CTD PMID:26934552 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
JBrowse link
G Cd9 CD9 molecule increases expression ISO Diclofenac results in increased expression of CD9 mRNA CTD PMID:26934552 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
JBrowse link
G Cdc42ep5 CDC42 effector protein 5 decreases expression ISO Diclofenac results in decreased expression of CDC42EP5 mRNA CTD PMID:26934552 NCBI chr 1:70,035,921...70,038,990 JBrowse link
G Cdc6 cell division cycle 6 affects expression ISO Diclofenac affects the expression of CDC6 mRNA CTD PMID:24752500 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Cdc7 cell division cycle 7 affects expression ISO Diclofenac affects the expression of CDC7 mRNA CTD PMID:24752500 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
JBrowse link
G Cdca5 cell division cycle associated 5 increases expression ISO Diclofenac results in increased expression of CDCA5 mRNA CTD PMID:26934552 NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023
JBrowse link
G Cdh1 cadherin 1 increases expression
affects expression
decreases expression
ISO
EXP
Diclofenac results in increased expression of CDH1 protein
Diclofenac affects the expression of CDH1 mRNA
Diclofenac results in decreased expression of CDH1 mRNA
CTD PMID:19022234 PMID:19628293 PMID:24752500 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk2 cyclin dependent kinase 2 affects expression ISO Diclofenac affects the expression of CDK2 mRNA CTD PMID:24752500 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk5 cyclin-dependent kinase 5 affects expression ISO Diclofenac affects the expression of CDK5 mRNA CTD PMID:24752500 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression EXP Diclofenac results in increased expression of CDK5R1 mRNA CTD PMID:30723492 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Diclofenac affects the expression of CDK6 mRNA CTD PMID:24752500 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdk7 cyclin-dependent kinase 7 affects expression ISO Diclofenac affects the expression of CDK7 mRNA CTD PMID:24752500 NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP
Diclofenac results in increased expression of CDKN1A mRNA CTD PMID:19022234 PMID:26934552 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO Diclofenac affects the expression of CDKN1B mRNA CTD PMID:24752500 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 affects expression ISO Diclofenac affects the expression of CDT1 mRNA CTD PMID:24752500 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
affects expression
ISO
EXP
Diclofenac results in increased expression of CEBPB mRNA
Diclofenac affects the expression of CEBPB mRNA
CTD PMID:19022234 PMID:24752500 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma decreases expression ISO Diclofenac results in decreased expression of CEBPG mRNA CTD PMID:35537566 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
JBrowse link
G Cep162 centrosomal protein 162 decreases expression ISO Diclofenac results in decreased expression of CEP162 mRNA CTD PMID:35537566 NCBI chr 8:88,149,726...88,208,249
Ensembl chr 8:88,149,726...88,206,830
JBrowse link
G Cers6 ceramide synthase 6 increases expression ISO Diclofenac results in increased expression of CERS6 mRNA CTD PMID:26934552 NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848
JBrowse link
G Ces1d carboxylesterase 1D decreases expression ISO Diclofenac results in decreased expression of CES1D mRNA CTD PMID:26934552 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Cfap97d1 CFAP97 domain containing 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CFAP97D1 mRNA CTD PMID:37844793 NCBI chr10:86,933,585...86,944,566
Ensembl chr10:86,933,808...86,938,244
JBrowse link
G Cfh complement factor H increases expression ISO Diclofenac results in increased expression of CFH mRNA CTD PMID:26934552 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
affects expression
ISO [Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein
Diclofenac affects the expression of CFLAR mRNA
CTD PMID:20237495 PMID:24752500 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 decreases expression ISO Diclofenac results in decreased expression of CGREF1 mRNA CTD PMID:26934552 NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression
decreases expression
ISO Diclofenac results in increased expression of CHAC1 mRNA
Diclofenac results in decreased expression of CHAC1 mRNA
CTD PMID:26934552 PMID:35537566 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
JBrowse link
G Chchd1 coiled-coil-helix-coiled-coil-helix domain containing 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CHCHD1 mRNA CTD PMID:37844793 NCBI chr15:3,592,719...3,593,901
Ensembl chr15:3,592,727...3,593,901
JBrowse link
G Chdh choline dehydrogenase affects expression ISO Diclofenac affects the expression of CHDH mRNA CTD PMID:24752500 NCBI chr16:5,194,269...5,225,541
Ensembl chr16:5,194,269...5,225,537
JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO Diclofenac affects the expression of CHEK1 mRNA CTD PMID:24752500 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chka choline kinase alpha affects expression ISO Diclofenac affects the expression of CHKA mRNA CTD PMID:24752500 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
JBrowse link
G Chkb choline kinase beta affects expression ISO Diclofenac affects the expression of CHKB mRNA CTD PMID:24752500 NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461
JBrowse link
G Chl1 cell adhesion molecule L1-like increases expression ISO Diclofenac results in increased expression of CHL1 mRNA CTD PMID:26934552 NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265
JBrowse link
G Chst4 carbohydrate sulfotransferase 4 decreases expression ISO Diclofenac results in decreased expression of CHST4 mRNA CTD PMID:26934552 NCBI chr19:37,993,471...38,002,123
Ensembl chr19:37,991,417...38,003,608
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO
EXP
Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein]
CTD PMID:15489888 PMID:25935278 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cib1 calcium and integrin binding 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CIB1 mRNA CTD PMID:37844793 NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423
JBrowse link
G Clec4a C-type lectin domain family 4, member A increases expression ISO Diclofenac results in increased expression of CLEC4N mRNA CTD PMID:26934552 NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402
JBrowse link
G Clu clusterin increases expression
multiple interactions
ISO
EXP
Diclofenac results in increased expression of CLU protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein
CTD PMID:23506792 PMID:25772430 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cmpk2 cytidine/uridine monophosphate kinase 2 affects expression ISO Diclofenac affects the expression of CMPK2 mRNA CTD PMID:24752500 NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions
ISO
EXP
Diclofenac results in decreased expression of COL3A1 mRNA
[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein]
CTD PMID:26934552 PMID:31042592 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 increases expression ISO Diclofenac results in increased expression of COTL1 mRNA CTD PMID:26934552 NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689
JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 increases expression ISO Diclofenac results in increased expression of COX4I2 mRNA CTD PMID:35537566 NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331
JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 decreases expression ISO Diclofenac results in decreased expression of COX6A2 mRNA CTD PMID:35537566 NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274
JBrowse link
G Cpb2 carboxypeptidase B2 increases expression ISO Diclofenac results in increased expression of CPB2 mRNA CTD PMID:26934552 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
JBrowse link
G Cplx1 complexin 1 increases expression EXP Diclofenac results in increased expression of CPLX1 mRNA CTD PMID:30723492 NCBI chr14:1,184,677...1,216,392 JBrowse link
G Cplx4 complexin 4 increases expression EXP Diclofenac results in increased expression of CPLX4 mRNA CTD PMID:30723492 NCBI chr18:59,481,360...59,504,716
Ensembl chr18:59,481,986...59,497,778
JBrowse link
G Cpne8 copine 8 increases expression ISO Diclofenac results in increased expression of CPNE8 mRNA CTD PMID:26934552 NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377
JBrowse link
G Cpsf6 cleavage and polyadenylation specific factor 6 affects expression ISO Diclofenac affects the expression of CPSF6 mRNA CTD PMID:24752500 NCBI chr 7:52,956,589...53,001,783
Ensembl chr 7:52,956,589...52,988,122
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO
EXP
Diclofenac results in increased expression of CPT1A mRNA CTD PMID:19022234 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cr1l complement C3b/C4b receptor 1 like multiple interactions EXP [Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein] CTD PMID:31042592 NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Cr2 complement C3d receptor 2 affects expression ISO Diclofenac affects the expression of CR2 mRNA CTD PMID:26934552 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 increases expression ISO Diclofenac results in increased expression of CREB3L2 mRNA CTD PMID:26934552 NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763
JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 affects expression ISO Diclofenac affects the expression of CREB3L4 mRNA CTD PMID:24752500 NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932
JBrowse link
G Crp C-reactive protein multiple interactions
decreases expression
EXP
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CRP protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CRP protein]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Diclofenac results in decreased expression of CRP protein]
Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]
CTD PMID:25772430 PMID:27313093 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Diclofenac results in decreased expression of CRY1 mRNA CTD PMID:26934552 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
JBrowse link
G Csf1 colony stimulating factor 1 decreases expression ISO Diclofenac results in decreased expression of CSF1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression
increases secretion
ISO Diclofenac results in increased expression of CSF1R mRNA
Diclofenac results in increased secretion of CSF1R protein
CTD PMID:26934552 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Diclofenac results in increased expression of CSF2RB mRNA; Diclofenac results in increased expression of CSF2RB2 mRNA CTD PMID:26934552 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 affects expression ISO Diclofenac affects the expression of CSNK2A1 mRNA CTD PMID:24752500 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 affects expression ISO Diclofenac affects the expression of CSNK2A2 mRNA CTD PMID:24752500 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080
JBrowse link
G Csrnp3 cysteine and serine rich nuclear protein 3 increases expression EXP Diclofenac results in increased expression of CSRNP3 mRNA CTD PMID:30723492 NCBI chr 3:50,498,379...50,695,598
Ensembl chr 3:50,498,633...50,685,950
JBrowse link
G Cstf2 cleavage stimulation factor subunit 2 affects expression ISO Diclofenac affects the expression of CSTF2 mRNA CTD PMID:24752500 NCBI chr  X:97,253,559...97,279,476
Ensembl chr  X:97,253,586...97,279,476
JBrowse link
G Cstf3 cleavage stimulation factor subunit 3 affects expression ISO Diclofenac affects the expression of CSTF3 mRNA CTD PMID:24752500 NCBI chr 3:90,966,415...91,037,669
Ensembl chr 3:90,966,354...91,042,196
JBrowse link
G Ctbp2 C-terminal binding protein 2 affects expression ISO Diclofenac affects the expression of CTBP2 mRNA CTD PMID:24752500 NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222
JBrowse link
G Cth cystathionine gamma-lyase affects expression
decreases expression
ISO Diclofenac affects the expression of CTH mRNA
Diclofenac results in decreased expression of CTH mRNA
CTD PMID:24752500 PMID:35537566 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 increases expression ISO Diclofenac results in increased expression of CTLA4 protein CTD PMID:26934552 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Ctnnb1 catenin beta 1 affects expression ISO Diclofenac affects the expression of CTNNB1 mRNA CTD PMID:24752500 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctps1 CTP synthase 1 affects expression ISO Diclofenac affects the expression of CTPS1 mRNA CTD PMID:24752500 NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
JBrowse link
G Ctps2 CTP synthase 2 affects expression ISO Diclofenac affects the expression of CTPS2 mRNA CTD PMID:24752500 NCBI chr  X:31,645,873...31,786,733
Ensembl chr  X:31,645,873...31,786,733
JBrowse link
G Ctsc cathepsin C increases expression ISO Diclofenac results in increased expression of CTSC mRNA CTD PMID:26934552 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Ctse cathepsin E decreases expression ISO Diclofenac results in decreased expression of CTSE mRNA CTD PMID:35537566 NCBI chr13:43,091,954...43,114,509
Ensembl chr13:43,092,128...43,114,502
JBrowse link
G Ctss cathepsin S increases expression ISO Diclofenac results in increased expression of CTSS mRNA CTD PMID:26934552 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cul3 cullin 3 affects expression ISO Diclofenac affects the expression of CUL3 mRNA CTD PMID:24752500 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462
JBrowse link
G Cul7 cullin 7 decreases expression ISO Diclofenac results in decreased expression of CUL7 mRNA CTD PMID:26934552 NCBI chr 9:14,319,102...14,333,035
Ensembl chr 9:14,319,108...14,332,741
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein] CTD PMID:23939143 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression ISO Diclofenac results in increased expression of CXCL13 mRNA CTD PMID:26934552 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO Diclofenac results in increased expression of CXCL14 mRNA CTD PMID:26934552 NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression
EXP
ISO
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 mRNA]
Diclofenac results in increased expression of CXCL2 mRNA; Diclofenac results in increased expression of CXCL2 protein
CTD PMID:22285467 PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
decreases expression
ISO Diclofenac results in increased expression of CXCL1 mRNA; Diclofenac results in increased expression of CXCL1 protein
Diclofenac results in decreased expression of CXCL1 mRNA
CTD PMID:26934552 PMID:27671914 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Diclofenac results in decreased expression of CXCR4 mRNA CTD PMID:19192274 PMID:35537566 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyb561 cytochrome b-561 increases expression ISO Diclofenac results in increased expression of CYB561 mRNA CTD PMID:26934552 NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787
JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression ISO Diclofenac results in increased expression of CYBA mRNA CTD PMID:26934552 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO Diclofenac results in increased expression of CYBB mRNA CTD PMID:26934552 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic affects expression ISO Diclofenac affects the expression of CYCS mRNA CTD PMID:24752500 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Diclofenac results in increased expression of CYP17A1 mRNA CTD PMID:26934552 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of CYP19A1 mRNA CTD PMID:37844793 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
ISO Diclofenac results in increased expression of CYP1A1 mRNA; Diclofenac results in increased expression of CYP1A1 protein
Diclofenac results in decreased activity of CYP1A1 protein
CTD PMID:18420780 PMID:21784029 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases activity
multiple interactions
ISO Diclofenac results in increased expression of CYP1A2 mRNA; Diclofenac results in increased expression of CYP1A2 protein
Diclofenac metabolite results in decreased activity of CYP1A2 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac
CTD PMID:21784029 PMID:23397584 PMID:28960974 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Diclofenac results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Diclofenac results in decreased expression of CYP26A1 mRNA CTD PMID:26934552 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of CYP26B1 mRNA CTD PMID:37844793 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity
affects expression
ISO Diclofenac results in decreased activity of CYP2A4 protein
Diclofenac affects the expression of CYP2A4 mRNA
CTD PMID:18420780 PMID:26934552 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Diclofenac results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 decreases expression ISO Diclofenac results in decreased expression of CYP2C55 mRNA CTD PMID:26934552 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases hydroxylation
decreases activity
increases response to substance
multiple interactions
EXP
ISO
CYP2C6 protein results in increased hydroxylation of Diclofenac
Diclofenac results in decreased activity of CYP2C29 protein
CYP2C19 protein results in increased susceptibility to Diclofenac
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac
CYP2C19 protein results in increased hydroxylation of Diclofenac
CTD PMID:11911841 PMID:15486075 PMID:18420780 PMID:18511451 PMID:23397584 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac CTD PMID:23397584 PMID:24246759 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Diclofenac metabolite results in decreased activity of CYP2E1 protein CTD PMID:28960974 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases expression ISO Diclofenac results in increased expression of CYP39A1 mRNA CTD PMID:26934552 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases metabolic processing
increases expression
multiple interactions
increases response to substance
ISO Diclofenac metabolite results in decreased activity of CYP3A4 protein; Diclofenac results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of Diclofenac
Diclofenac results in increased expression of CYP3A4 mRNA
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
CYP3A4 protein results in increased susceptibility to Diclofenac
CTD PMID:15135088 PMID:19022234 PMID:23397584 PMID:24104198 PMID:24246759 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Diclofenac results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19022234 PMID:29027214 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity
increases expression
ISO Diclofenac metabolite results in decreased activity of CYP3A13 protein
Diclofenac results in increased expression of CYP3A13 mRNA
CTD PMID:26934552 PMID:28960974 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 increases hydroxylation ISO CYP46A1 protein results in increased hydroxylation of Diclofenac CTD PMID:14640697 NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760
JBrowse link
G Cyp4f39 cytochrome P450, family 4, subfamily f, polypeptide 39 decreases expression ISO Diclofenac results in decreased expression of CYP4F39 mRNA CTD PMID:35537566 NCBI chr 7:11,426,806...11,505,553
Ensembl chr 7:11,433,371...11,536,181
JBrowse link
G Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 decreases expression ISO Diclofenac results in decreased expression of CYP4V3 mRNA CTD PMID:26934552 NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
increases expression
ISO Diclofenac metabolite results in decreased activity of CYP51A1 protein
Diclofenac results in increased expression of CYP51 mRNA
CTD PMID:26934552 PMID:28960974 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Diclofenac results in increased expression of CYP7A1 mRNA CTD PMID:26934552 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Diclofenac results in decreased expression of CYP8B1 mRNA CTD PMID:26934552 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dap death-associated protein increases expression ISO Diclofenac results in increased expression of DAP mRNA CTD PMID:26934552 NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 affects expression ISO Diclofenac affects the expression of DBT mRNA CTD PMID:24752500 NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609
JBrowse link
G Dctpp1 dCTP pyrophosphatase 1 affects expression ISO Diclofenac affects the expression of DCTPP1 mRNA CTD PMID:24752500 NCBI chr 1:181,877,440...181,880,833
Ensembl chr 1:181,877,437...181,880,839
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases response to substance
decreases expression
increases expression
ISO
EXP
DDIT3 results in increased susceptibility to Diclofenac
Diclofenac results in decreased expression of DDIT3 mRNA
Diclofenac results in increased expression of DDIT3 mRNA; Diclofenac results in increased expression of DDIT3 protein
CTD PMID:18172885 PMID:20668000 PMID:24752500 PMID:27313093 PMID:27358234 More... NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Diclofenac results in increased expression of DDIT4 mRNA CTD PMID:26934552 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 affects expression ISO Diclofenac affects the expression of DDR1 mRNA CTD PMID:24752500 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
JBrowse link
G Ddt D-dopachrome tautomerase decreases expression ISO Diclofenac results in decreased expression of DDT mRNA CTD PMID:26934552 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482
JBrowse link
G Ddx5 DEAD-box helicase 5 affects expression ISO Diclofenac affects the expression of DDX5 mRNA CTD PMID:24752500 NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 increases expression EXP Diclofenac results in increased expression of DECR1 protein CTD PMID:25772430 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
JBrowse link
G Dennd2d DENN domain containing 2D decreases expression ISO Diclofenac results in decreased expression of DENND2D mRNA CTD PMID:35537566 NCBI chr 2:193,973,231...193,992,275
Ensembl chr 2:193,973,231...193,992,270
JBrowse link
G Derl1 derlin 1 increases expression ISO Diclofenac results in increased expression of DERL1 mRNA CTD PMID:26934552 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145
JBrowse link
G Derl3 derlin 3 increases expression ISO Diclofenac results in increased expression of DERL3 mRNA CTD PMID:26934552 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027
JBrowse link
G Dffa DNA fragmentation factor subunit alpha affects expression ISO Diclofenac affects the expression of DFFA mRNA CTD PMID:24752500 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO Diclofenac results in increased expression of DHCR24 mRNA CTD PMID:26934552 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhfr dihydrofolate reductase affects expression ISO Diclofenac affects the expression of DHFR mRNA CTD PMID:24752500 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 decreases expression ISO Diclofenac results in decreased expression of DHRS3 mRNA CTD PMID:35537566 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 affects expression ISO Diclofenac affects the expression of DKK1 mRNA CTD PMID:24752500 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Dnaaf2 dynein, axonemal, assembly factor 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of DNAAF2 mRNA CTD PMID:37844793 NCBI chr 6:87,661,101...87,670,267
Ensembl chr 6:87,660,821...87,670,199
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 affects expression ISO Diclofenac affects the expression of DNAJA1 mRNA CTD PMID:24752500 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 affects expression ISO Diclofenac affects the expression of DNAJA2 mRNA CTD PMID:24752500 NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 affects expression
decreases expression
ISO Diclofenac affects the expression of DNAJA3 mRNA
Diclofenac results in decreased expression of DNAJA3 mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 affects expression ISO Diclofenac affects the expression of DNAJB1 mRNA CTD PMID:24752500 NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
JBrowse link
G Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 affects expression ISO Diclofenac affects the expression of DNAJB14 mRNA CTD PMID:24752500 NCBI chr 2:226,358,988...226,409,461
Ensembl chr 2:226,358,996...226,402,490
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 affects expression ISO Diclofenac affects the expression of DNAJB4 mRNA CTD PMID:24752500 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 affects expression ISO Diclofenac affects the expression of DNAJB6 mRNA CTD PMID:24752500 NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659
JBrowse link
G Dnajb7 DnaJ heat shock protein family (Hsp40) member B7 increases expression EXP Diclofenac results in increased expression of DNAJB7 mRNA CTD PMID:30723492 NCBI chr 7:112,932,736...112,934,050
Ensembl chr 7:112,932,616...112,945,537
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 affects expression
increases expression
ISO Diclofenac affects the expression of DNAJB9 mRNA
Diclofenac results in increased expression of DNAJB9 mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 affects expression
increases expression
ISO Diclofenac affects the expression of DNAJC10 mRNA
Diclofenac results in increased expression of DNAJC10 mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719
JBrowse link
G Dnajc11 DnaJ heat shock protein family (Hsp40) member C11 affects expression ISO Diclofenac affects the expression of DNAJC11 mRNA CTD PMID:24752500 NCBI chr 5:162,442,042...162,487,966
Ensembl chr 5:162,442,026...162,488,169
JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 increases expression
decreases expression
ISO Diclofenac results in increased expression of DNAJC12 mRNA
Diclofenac results in decreased expression of DNAJC12 mRNA
CTD PMID:26934552 NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521
JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 affects expression ISO Diclofenac affects the expression of DNAJC15 mRNA CTD PMID:24752500 NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
JBrowse link
G Dnajc18 DnaJ heat shock protein family (Hsp40) member C18 affects expression ISO Diclofenac affects the expression of DNAJC18 mRNA CTD PMID:24752500 NCBI chr18:27,269,350...27,303,453
Ensembl chr18:27,269,355...27,298,344
JBrowse link
G Dnajc21 DnaJ heat shock protein family (Hsp40) member C21 affects expression ISO Diclofenac affects the expression of DNAJC21 mRNA CTD PMID:24752500 NCBI chr 2:59,419,507...59,446,746
Ensembl chr 2:59,419,510...59,446,752
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Diclofenac results in increased expression of DNAJC3 mRNA CTD PMID:26934552 NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 affects expression ISO Diclofenac affects the expression of DNAJC5 mRNA CTD PMID:24752500 NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935
JBrowse link
G Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 affects expression ISO Diclofenac affects the expression of DNAJC6 mRNA CTD PMID:24752500 NCBI chr 5:116,120,069...116,283,448
Ensembl chr 5:116,119,676...116,283,448
JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 affects expression ISO Diclofenac affects the expression of DNAJC7 mRNA CTD PMID:24752500 NCBI chr10:85,518,637...85,555,079
Ensembl chr10:85,518,621...85,555,575
JBrowse link
G Dnajc8 DnaJ heat shock protein family (Hsp40) member C8 affects expression ISO Diclofenac affects the expression of DNAJC8 mRNA CTD PMID:24752500 NCBI chr 5:144,745,055...144,763,106
Ensembl chr 5:144,745,036...144,763,108
JBrowse link
G Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 affects expression ISO Diclofenac affects the expression of DNAJC9 mRNA CTD PMID:24752500 NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118
JBrowse link
G Dnd1 DND microRNA-mediated repression inhibitor 1 increases expression ISO Diclofenac results in increased expression of DND1 mRNA CTD PMID:35537566 NCBI chr18:28,378,692...28,381,316
Ensembl chr18:28,378,692...28,381,316
JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression ISO Diclofenac results in decreased expression of DNER mRNA CTD PMID:35537566 NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 affects expression ISO Diclofenac affects the expression of DPYSL2 mRNA CTD PMID:24752500 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Drd1 dopamine receptor D1 increases expression ISO Diclofenac results in increased expression of DRD1 mRNA CTD PMID:26934552 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Dtymk deoxythymidylate kinase affects expression ISO Diclofenac affects the expression of DTYMK mRNA CTD PMID:24752500 NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression
decreases expression
ISO Diclofenac affects the expression of DUSP1 mRNA
Diclofenac results in decreased expression of DUSP1 mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dut deoxyuridine triphosphatase affects expression ISO Diclofenac affects the expression of DUT mRNA CTD PMID:24752500 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 increases expression EXP Diclofenac results in increased expression of DYNC1I1 mRNA CTD PMID:30723492 NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149
JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO Diclofenac affects the expression of E2F1 mRNA CTD PMID:24752500 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO Diclofenac affects the expression of E2F2 mRNA CTD PMID:24752500 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G E2f5 E2F transcription factor 5 affects expression ISO Diclofenac affects the expression of E2F5 mRNA CTD PMID:24752500 NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Ebln1 endogenous Bornavirus like nucleoprotein 1 increases expression EXP Diclofenac results in increased expression of IGKV8-24 mRNA CTD PMID:30723492 NCBI chr10:78,938,645...78,940,651 JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO Diclofenac results in decreased expression of ECM1 mRNA CTD PMID:26934552 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
JBrowse link
G Ect2 epithelial cell transforming 2 increases expression ISO Diclofenac results in increased expression of ECT2 mRNA CTD PMID:26934552 NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Diclofenac results in increased expression of EDEM1 mRNA CTD PMID:26934552 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 decreases expression ISO Diclofenac results in decreased expression of EDIL3 mRNA CTD PMID:26934552 NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium] CTD PMID:15083534 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Edn2 endothelin 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of EDN2 mRNA CTD PMID:37844793 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression ISO Diclofenac results in decreased expression of EEF2K mRNA CTD PMID:35537566 NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164
JBrowse link
G Egf epidermal growth factor increases expression ISO Diclofenac results in increased expression of EGF protein CTD PMID:23506792 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Diclofenac results in increased expression of EGFR mRNA CTD PMID:26934552 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
affects expression
ISO Diclofenac results in increased expression of EGR1 mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of EGR1 mRNA
Diclofenac affects the expression of EGR1 mRNA
CTD PMID:15509713 PMID:26934552 PMID:37844793 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 affects expression ISO Diclofenac affects the expression of EIF1 mRNA CTD PMID:24752500 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
JBrowse link
G Eif1a eukaryotic translation initiation factor 1A increases expression ISO Diclofenac results in increased expression of EIF1A mRNA CTD PMID:26934552 NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696
JBrowse link
G Eif1ax eukaryotic translation initiation factor 1A, X-linked affects expression ISO Diclofenac affects the expression of EIF1AX mRNA CTD PMID:24752500 NCBI chr  X:35,498,698...35,513,402
Ensembl chr  X:35,498,517...35,513,335
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A affects expression ISO Diclofenac affects the expression of EIF2A mRNA CTD PMID:24752500 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 affects expression
decreases expression
ISO Diclofenac affects the expression of EIF2AK1 mRNA
Diclofenac results in decreased expression of EIF2AK1 mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 affects expression
increases expression
increases phosphorylation
multiple interactions
increases activity
ISO Diclofenac affects the expression of EIF2AK3 mRNA
Diclofenac results in increased expression of EIF2AK3 mRNA
Diclofenac results in increased phosphorylation of EIF2AK3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]
Diclofenac results in increased activity of EIF2AK3 protein
CTD PMID:24752500 PMID:26609140 PMID:26934552 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 affects expression ISO Diclofenac affects the expression of EIF2AK4 mRNA CTD PMID:24752500 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630
JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha affects expression ISO Diclofenac affects the expression of EIF2B1 mRNA CTD PMID:24752500 NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects expression
multiple interactions
ISO Diclofenac affects the expression of EIF2S1 mRNA
[TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein
CTD PMID:24752500 PMID:27313093 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta affects expression ISO Diclofenac affects the expression of EIF2S2 mRNA CTD PMID:24752500 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A affects expression ISO Diclofenac affects the expression of EIF3A mRNA CTD PMID:24752500 NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976
JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B affects expression ISO Diclofenac affects the expression of EIF3B mRNA CTD PMID:24752500 NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C affects expression ISO Diclofenac affects the expression of EIF3C mRNA CTD PMID:24752500 NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 affects expression ISO Diclofenac affects the expression of EIF4A1 mRNA CTD PMID:24752500 NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 affects expression ISO Diclofenac affects the expression of EIF4A2 mRNA CTD PMID:24752500 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression
decreases expression
affects expression
EXP
ISO
Diclofenac results in increased expression of EIF4EBP1 mRNA
Diclofenac results in decreased expression of EIF4EBP1 mRNA
Diclofenac affects the expression of EIF4EBP1 mRNA
CTD PMID:18172885 PMID:24752500 PMID:35537566 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 affects expression ISO Diclofenac affects the expression of EIF4G1 mRNA CTD PMID:24752500 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 affects expression ISO Diclofenac affects the expression of EIF4G3 mRNA CTD PMID:24752500 NCBI chr 5:150,197,410...150,418,862
Ensembl chr 5:150,195,226...150,418,363
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 affects expression ISO Diclofenac affects the expression of EIF5 mRNA CTD PMID:24752500 NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656
JBrowse link
G Elf2 E74 like ETS transcription factor 2 affects expression ISO Diclofenac affects the expression of ELF2 mRNA CTD PMID:24752500 NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947
JBrowse link
G Elf3 E74 like ETS transcription factor 3 affects expression ISO Diclofenac affects the expression of ELF3 mRNA CTD PMID:24752500 NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481
JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 affects expression ISO Diclofenac affects the expression of ELOVL2 mRNA CTD PMID:24752500 NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Diclofenac results in increased expression of ELOVL6 mRNA CTD PMID:35537566 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 increases expression ISO Diclofenac results in increased expression of EME2 mRNA CTD PMID:26934552 NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968
JBrowse link
G Endog endonuclease G affects expression ISO Diclofenac affects the expression of ENDOG mRNA CTD PMID:24752500 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Eno1 enolase 1 increases expression ISO Diclofenac results in increased expression of ENO1 mRNA CTD PMID:26934552 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 affects expression ISO Diclofenac affects the expression of ENPP1 mRNA CTD PMID:24752500 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO Diclofenac results in increased expression of ENPP2 mRNA CTD PMID:26934552 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 affects expression ISO Diclofenac affects the expression of ENTPD4 mRNA CTD PMID:24752500 NCBI chr15:44,630,878...44,658,654
Ensembl chr15:44,630,873...44,658,706
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 affects expression ISO Diclofenac affects the expression of ENTPD5 mRNA CTD PMID:24752500 NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 affects expression ISO Diclofenac affects the expression of ENTPD7 mRNA CTD PMID:24752500 NCBI chr 1:242,559,365...242,601,044
Ensembl chr 1:242,559,365...242,601,447
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO Diclofenac results in decreased expression of EPAS1 protein CTD PMID:12912967 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epc2 enhancer of polycomb homolog 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of EPC2 mRNA CTD PMID:37844793 NCBI chr 3:33,867,219...33,967,908
Ensembl chr 3:33,867,219...33,967,150
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP Diclofenac results in decreased expression of EPHX1 mRNA CTD PMID:17202759 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Epn2 epsin 2 affects expression ISO Diclofenac affects the expression of EPN2 mRNA CTD PMID:24752500 NCBI chr10:46,197,785...46,259,673
Ensembl chr10:46,197,785...46,259,642
JBrowse link
G Epn3 epsin 3 affects expression ISO Diclofenac affects the expression of EPN3 mRNA CTD PMID:24752500 NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356
JBrowse link
G Epo erythropoietin affects expression ISO Diclofenac affects the expression of EPO mRNA CTD PMID:24752500 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ERBB4 mRNA CTD PMID:37844793 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Ereg epiregulin increases expression ISO Diclofenac results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 affects expression ISO Diclofenac affects the expression of ERN1 mRNA CTD PMID:24752500 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Diclofenac results in increased expression of ERO1A mRNA CTD PMID:26934552 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
JBrowse link
G Esr1 estrogen receptor 1 affects activity ISO Diclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase decreases expression ISO Diclofenac results in decreased expression of ETNPPL mRNA CTD PMID:26934552 NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212
JBrowse link
G Evi5 ecotropic viral integration site 5 decreases expression ISO Diclofenac results in decreased expression of EVI5 mRNA CTD PMID:35537566 NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678
JBrowse link
G Extl1 exostosin-like glycosyltransferase 1 decreases expression ISO Diclofenac results in decreased expression of EXTL1 mRNA CTD PMID:35537566 NCBI chr 5:146,573,911...146,589,115
Ensembl chr 5:146,573,912...146,589,115
JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 decreases expression ISO Diclofenac results in decreased expression of EYA4 mRNA CTD PMID:26934552 NCBI chr 1:22,172,275...22,415,978
Ensembl chr 1:22,172,275...22,415,976
JBrowse link
G F13a1 coagulation factor XIII A1 chain increases expression ISO Diclofenac results in increased expression of F13A1 mRNA CTD PMID:26934552 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
JBrowse link
G Faap24 FA core complex associated protein 24 increases expression ISO Diclofenac results in increased expression of FAAP24 mRNA CTD PMID:26934552 NCBI chr 1:88,051,523...88,057,997
Ensembl chr 1:88,051,911...88,057,989
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression
increases expression
ISO Diclofenac results in decreased expression of FABP1 mRNA
Diclofenac results in increased expression of FABP1 protein
CTD PMID:19022234 PMID:23506792 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp2 fatty acid binding protein 2 decreases expression EXP
ISO
Diclofenac results in decreased expression of FABP2 mRNA CTD PMID:19022234 PMID:26934552 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FABP3 mRNA CTD PMID:37844793 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Diclofenac results in decreased expression of FABP4 mRNA CTD PMID:35537566 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO Diclofenac results in increased expression of FABP5 mRNA CTD PMID:26934552 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression ISO Diclofenac results in decreased expression of FADS1 mRNA CTD PMID:26934552 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fam209 family with sequence similarity 209 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FAM209 mRNA CTD PMID:37844793 NCBI chr 3:161,240,062...161,241,747
Ensembl chr 3:161,240,034...161,241,755
JBrowse link
G Fancb FA complementation group B affects expression ISO Diclofenac affects the expression of FANCB mRNA CTD PMID:24752500 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192
JBrowse link
G Fancc FA complementation group C affects expression ISO Diclofenac affects the expression of FANCC mRNA CTD PMID:24752500 NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376
JBrowse link
G Fance FA complementation group E increases expression ISO Diclofenac results in increased expression of FANCE mRNA CTD PMID:26934552 NCBI chr20:6,369,416...6,386,631
Ensembl chr20:6,375,573...6,386,631
JBrowse link
G Fancf FA complementation group F affects expression ISO Diclofenac affects the expression of FANCF mRNA CTD PMID:24752500 NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923
JBrowse link
G Fancg FA complementation group G affects expression ISO Diclofenac affects the expression of FANCG mRNA CTD PMID:24752500 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029
JBrowse link
G Fancl FA complementation group L affects expression ISO Diclofenac affects the expression of FANCL mRNA CTD PMID:24752500 NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255
JBrowse link
G Fancm FA complementation group M affects expression ISO Diclofenac affects the expression of FANCM mRNA CTD PMID:24752500 NCBI chr 6:83,126,903...83,180,455
Ensembl chr 6:83,127,093...83,180,028
JBrowse link
G Fas Fas cell surface death receptor affects expression
increases expression
ISO Diclofenac affects the expression of FAS mRNA
Diclofenac results in increased expression of FAS mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO Diclofenac results in increased expression of FASL mRNA CTD PMID:22285467 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Diclofenac results in decreased expression of FASN mRNA CTD PMID:19022234 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fastk Fas-activated serine/threonine kinase multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FASTK mRNA CTD PMID:37844793 NCBI chr 4:10,732,273...10,736,332
Ensembl chr 4:10,732,256...10,737,430
JBrowse link
G Fastkd2 FAST kinase domains 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FASTKD2 mRNA CTD PMID:37844793 NCBI chr 9:65,166,148...65,188,184
Ensembl chr 9:65,168,228...65,188,174
JBrowse link
G Fbxo33 F-box protein 33 increases expression ISO Diclofenac results in increased expression of FBXO33 mRNA CTD PMID:35537566 NCBI chr 6:76,900,619...76,934,232
Ensembl chr 6:76,900,631...76,932,669
JBrowse link
G Fbxo5 F-box protein 5 decreases expression ISO Diclofenac results in decreased expression of FBXO5 mRNA CTD PMID:35537566 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Fcer1g Fc epsilon receptor Ig increases expression ISO Diclofenac results in increased expression of FCER1G mRNA CTD PMID:26934552 NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Fcgr2a Fc gamma receptor 2A increases expression ISO Diclofenac results in increased expression of FCGR3 mRNA CTD PMID:26934552 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
JBrowse link
G Fcgr2b Fc gamma receptor 2B decreases expression ISO Diclofenac results in decreased expression of FCGR2B mRNA CTD PMID:35537566 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression ISO Diclofenac results in increased expression of FEN1 mRNA CTD PMID:26934552 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Fer FER tyrosine kinase affects expression ISO Diclofenac affects the expression of FER mRNA CTD PMID:24752500 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451
JBrowse link
G Fermt1 FERM domain containing kindlin 1 increases expression EXP Diclofenac results in increased expression of FERMT1 mRNA CTD PMID:30723492 NCBI chr 3:120,171,301...120,213,555
Ensembl chr 3:120,171,561...120,213,555
JBrowse link
G Fgb fibrinogen beta chain multiple interactions
increases expression
EXP
ISO
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGB protein
Diclofenac results in increased expression of FGB mRNA
CTD PMID:25772430 PMID:26934552 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Diclofenac results in decreased expression of FGF1 mRNA CTD PMID:26934552 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf3 fibroblast growth factor 3 increases expression ISO Diclofenac results in increased expression of FGF3 mRNA CTD PMID:26934552 NCBI chr 1:200,001,162...200,005,539
Ensembl chr 1:200,001,261...200,005,187
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO Diclofenac affects the expression of FGFR1 mRNA CTD PMID:24752500 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgfr1op2 FGFR1 oncogene partner 2 decreases expression ISO Diclofenac results in decreased expression of FGFR1OP2 mRNA CTD PMID:26934552 NCBI chr 4:179,491,602...179,512,630
Ensembl chr 4:179,491,599...179,512,630
JBrowse link
G Fgg fibrinogen gamma chain multiple interactions
decreases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGG protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in decreased expression of FGG protein] CTD PMID:25772430 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Fgl1 fibrinogen-like 1 increases expression ISO Diclofenac results in increased expression of FGL1 mRNA CTD PMID:26934552 NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093
JBrowse link
G Fmod fibromodulin decreases expression ISO Diclofenac results in decreased expression of FMOD mRNA CTD PMID:26934552 NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Diclofenac results in increased expression of FN1 mRNA; Diclofenac results in increased expression of FN1 protein CTD PMID:26934552 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fnbp1 formin binding protein 1 affects expression ISO Diclofenac affects the expression of FNBP1 mRNA CTD PMID:24752500 NCBI chr 3:14,309,067...14,424,378
Ensembl chr 3:14,309,640...14,424,881
JBrowse link
G Fndc3b fibronectin type III domain containing 3B increases expression ISO Diclofenac results in increased expression of FNDC3B mRNA CTD PMID:26934552 NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830
JBrowse link
G Fnip1 folliculin interacting protein 1 decreases expression ISO Diclofenac results in decreased expression of FNIP1 mRNA CTD PMID:26934552 NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824
JBrowse link
G Fnip2 folliculin interacting protein 2 decreases expression ISO Diclofenac results in decreased expression of FNIP2 mRNA CTD PMID:26934552 NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
affects expression
ISO Diclofenac results in increased expression of FOS mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FOS mRNA
Diclofenac affects the expression of FOS mRNA
CTD PMID:12730611 PMID:24752500 PMID:37844793 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression ISO Diclofenac results in increased expression of FOSL2 mRNA CTD PMID:26934552 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Foxa1 forkhead box A1 affects expression ISO Diclofenac affects the expression of FOXA1 mRNA CTD PMID:24752500 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G Foxa3 forkhead box A3 increases expression ISO Diclofenac results in increased expression of FOXA3 mRNA CTD PMID:26934552 NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155
JBrowse link
G Foxo1 forkhead box O1 affects expression ISO Diclofenac affects the expression of FOXO1 mRNA CTD PMID:24752500 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxo3 forkhead box O3 affects expression
decreases expression
ISO Diclofenac affects the expression of FOXO3 mRNA
Diclofenac results in decreased expression of FOXO3 mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Fpr2 formyl peptide receptor 2 increases expression ISO Diclofenac results in increased expression of FPR2 mRNA CTD PMID:26934552 NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019
JBrowse link
G Frat2 FRAT regulator of WNT signaling pathway 2 decreases expression ISO Diclofenac results in decreased expression of FRAT2 mRNA CTD PMID:35537566 NCBI chr 1:240,654,120...240,656,449
Ensembl chr 1:240,654,137...240,656,517
JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 affects expression ISO Diclofenac affects the expression of FRS2 mRNA CTD PMID:24752500 NCBI chr 7:52,711,255...52,792,738
Ensembl chr 7:52,711,257...52,792,743
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase affects expression ISO Diclofenac affects the expression of FTCD mRNA CTD PMID:24752500 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735
JBrowse link
G Fyb1 FYN binding protein 1 increases expression ISO Diclofenac results in increased expression of FYB1 mRNA CTD PMID:26934552 NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629
JBrowse link
G Fzd3 frizzled class receptor 3 affects expression ISO Diclofenac affects the expression of FZD3 mRNA CTD PMID:24752500 NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369
JBrowse link
G Fzd4 frizzled class receptor 4 affects expression ISO Diclofenac affects the expression of FZD4 mRNA CTD PMID:24752500 NCBI chr 1:143,279,934...143,288,799
Ensembl chr 1:143,280,065...143,285,724
JBrowse link
G Fzd5 frizzled class receptor 5 affects expression ISO Diclofenac affects the expression of FZD5 mRNA CTD PMID:24752500 NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457
JBrowse link
G Fzd6 frizzled class receptor 6 affects expression ISO Diclofenac affects the expression of FZD6 mRNA CTD PMID:24752500 NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776
JBrowse link
G Fzd7 frizzled class receptor 7 affects expression ISO Diclofenac affects the expression of FZD7 mRNA CTD PMID:24752500 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
JBrowse link
G Gab1 GRB2-associated binding protein 1 affects expression ISO Diclofenac affects the expression of GAB1 mRNA CTD PMID:24752500 NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236
JBrowse link
G Gab2 GRB2-associated binding protein 2 affects expression ISO Diclofenac affects the expression of GAB2 mRNA CTD PMID:24752500 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 decreases expression ISO Diclofenac results in decreased expression of GABRA5 mRNA CTD PMID:26934552 NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
decreases expression
affects expression
ISO
EXP
Diclofenac results in increased expression of GADD45A mRNA
Diclofenac results in decreased expression of GADD45A mRNA
Diclofenac affects the expression of GADD45A mRNA
CTD PMID:18172885 PMID:19022234 PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Diclofenac results in increased expression of GADD45G mRNA CTD PMID:26934552 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 increases expression EXP Diclofenac results in increased expression of GALNT3 mRNA CTD PMID:30723492 NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268
JBrowse link
G Gars1 glycyl-tRNA synthetase 1 affects expression
decreases expression
ISO Diclofenac affects the expression of GARS1 mRNA
Diclofenac results in decreased expression of GARS1 mRNA
CTD PMID:24752500 PMID:35537566 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase affects expression ISO Diclofenac affects the expression of GART mRNA CTD PMID:24752500 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO Diclofenac results in decreased expression of GAS1 mRNA CTD PMID:26934552 NCBI chr17:4,482,168...4,485,153 JBrowse link
G Gata4 GATA binding protein 4 affects expression ISO Diclofenac affects the expression of GATA4 mRNA CTD PMID:24752500 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO Diclofenac results in increased expression of GATA6 mRNA CTD PMID:26934552 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Diclofenac results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131
JBrowse link
G Gbp4 guanylate binding protein 4 increases expression ISO Diclofenac results in increased expression of GBP3 mRNA CTD PMID:26934552 NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879
JBrowse link
G Gc GC, vitamin D binding protein multiple interactions EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GC protein CTD PMID:25772430 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
JBrowse link
G Gck glucokinase affects expression ISO Diclofenac affects the expression of GCK mRNA CTD PMID:26934552 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
affects expression
affects response to substance
EXP
ISO
Diclofenac results in decreased expression of GCLC mRNA
Diclofenac affects the expression of GCLC mRNA
GCLC protein affects the susceptibility to Diclofenac
CTD PMID:17202759 PMID:19481141 PMID:24752500 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit affects expression ISO Diclofenac affects the expression of GCLM mRNA CTD PMID:24752500 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Diclofenac results in increased expression of GDF15 mRNA
Diclofenac results in increased expression of GDF15 protein
CTD PMID:15555568 PMID:18076062 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gdf6 growth differentiation factor 6 increases expression EXP Diclofenac results in increased expression of GDF6 mRNA CTD PMID:30723492 NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567
JBrowse link
G Gdf9 growth differentiation factor 9 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of GDF9 mRNA CTD PMID:37844793 NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672
JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 increases expression ISO Diclofenac results in increased expression of GFPT1 mRNA CTD PMID:26934552 NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP [lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GGT1 protein CTD PMID:23939143 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Ghr growth hormone receptor affects expression ISO Diclofenac affects the expression of GHR protein CTD PMID:26934552 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
JBrowse link
G Git2 GIT ArfGAP 2 affects expression ISO Diclofenac affects the expression of GIT2 mRNA CTD PMID:24752500 NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Diclofenac results in increased expression of GJA1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja3 gap junction protein, alpha 3 increases expression ISO Diclofenac results in increased expression of GJA3 mRNA CTD PMID:26934552 NCBI chr15:31,181,360...31,206,820
Ensembl chr15:31,181,369...31,206,810
JBrowse link
G Gldc glycine decarboxylase affects expression ISO Diclofenac affects the expression of GLDC mRNA CTD PMID:24752500 NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097
JBrowse link
G Glyctk glycerate kinase affects expression ISO Diclofenac affects the expression of GLYCTK mRNA CTD PMID:24752500 NCBI chr 8:106,795,461...106,802,675
Ensembl chr 8:106,797,343...106,802,397
JBrowse link
G Gna13 G protein subunit alpha 13 affects expression ISO Diclofenac affects the expression of GNA13 mRNA CTD PMID:24752500 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774
JBrowse link
G Gnaq G protein subunit alpha q affects expression ISO Diclofenac affects the expression of GNAQ mRNA CTD PMID:24752500 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gnas GNAS complex locus affects expression ISO Diclofenac affects the expression of GNAS mRNA CTD PMID:24752500 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnat1 G protein subunit alpha transducin 1 increases expression ISO Diclofenac results in increased expression of GNAT1 mRNA CTD PMID:26934552 NCBI chr 8:108,350,935...108,355,671
Ensembl chr 8:108,350,935...108,355,671
JBrowse link
G Gnb5 G protein subunit beta 5 affects expression ISO Diclofenac affects the expression of GNB5 mRNA CTD PMID:24752500 NCBI chr 8:76,076,120...76,105,069
Ensembl chr 8:76,073,306...76,105,069
JBrowse link
G Gng4 G protein subunit gamma 4 affects expression ISO Diclofenac affects the expression of GNG4 mRNA CTD PMID:24752500 NCBI chr17:86,448,708...86,497,560
Ensembl chr17:86,449,022...86,495,254
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects expression
increases secretion
ISO Diclofenac affects the expression of GOT1 mRNA
Diclofenac results in increased secretion of GOT1 protein
CTD PMID:24752500 PMID:36442613 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions EXP Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of GPD1 protein] CTD PMID:25772430 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 affects expression ISO Diclofenac affects the expression of GPLD1 mRNA CTD PMID:24752500 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939
JBrowse link
G Gpr176 G protein-coupled receptor 176 decreases expression ISO Diclofenac results in decreased expression of GPR176 mRNA CTD PMID:35537566 NCBI chr 3:105,236,794...105,337,664
Ensembl chr 3:105,236,795...105,337,226
JBrowse link
G Gpr20 G protein-coupled receptor 20 decreases expression EXP Diclofenac results in decreased expression of GPR20 mRNA CTD PMID:30723492 NCBI chr 7:105,601,761...105,611,959
Ensembl chr 7:105,602,368...105,603,430
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases secretion
increases expression
increases activity
EXP
ISO
[lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GPT protein; Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]; Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]]
Diclofenac results in increased secretion of GPT protein
Diclofenac results in increased expression of GPT protein
Diclofenac results in increased activity of GPT protein
eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]
CTD PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 PMID:30925002 More... NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 decreases expression ISO Diclofenac results in decreased expression of GPT2 mRNA CTD PMID:35537566 NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression EXP
ISO
Diclofenac results in increased expression of GPX1 mRNA; Diclofenac results in increased expression of GPX1 protein CTD PMID:25772430 PMID:29027214 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 affects expression ISO Diclofenac affects the expression of GPX2 mRNA CTD PMID:24752500 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Grb10 growth factor receptor bound protein 10 affects expression ISO Diclofenac affects the expression of GRB10 mRNA CTD PMID:24752500 NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806
JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of GRID2 mRNA CTD PMID:37844793 NCBI chr 4:92,415,019...93,892,472
Ensembl chr 4:92,415,230...93,889,355
JBrowse link
G Grm7 glutamate metabotropic receptor 7 increases expression ISO Diclofenac results in increased expression of GRM7 mRNA CTD PMID:26934552 NCBI chr 4:143,730,862...144,613,230
Ensembl chr 4:143,731,259...144,612,344
JBrowse link
G Gsdmd gasdermin D increases cleavage
multiple interactions
EXP Diclofenac results in increased cleavage of GSDMD protein
diacerein inhibits the reaction [Diclofenac results in increased cleavage of GSDMD protein]
CTD PMID:38582345 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects expression ISO Diclofenac affects the expression of GSK3B mRNA CTD PMID:24752500 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsn gelsolin decreases expression ISO Diclofenac results in decreased expression of GSN mRNA CTD PMID:26934552 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Diclofenac results in decreased activity of GSTA1 protein CTD PMID:27183920 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases activity ISO Diclofenac results in decreased activity of GSTA4 protein CTD PMID:27183920 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
increases expression
EXP [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GSTA5 protein
Diclofenac results in increased expression of GSTA5 protein
CTD PMID:25772430 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity
decreases expression
ISO Diclofenac results in decreased activity of GSTM1 protein
Diclofenac results in decreased expression of GSTM1 mRNA
CTD PMID:26934552 PMID:27183920 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity ISO Diclofenac results in decreased activity of GSTM2 protein CTD PMID:27183920 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects activity ISO Diclofenac affects the activity of GSTM4 protein CTD PMID:27183920 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Diclofenac results in increased expression of GSTM3 mRNA CTD PMID:26934552 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
affects activity
affects metabolic processing
ISO [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
Diclofenac affects the activity of GSTP1 protein
GSTP1 protein affects the metabolism of Diclofenac metabolite; GSTP1 protein polymorphism affects the metabolism of Diclofenac metabolite
CTD PMID:24185126 PMID:24246759 PMID:27183920 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects expression
affects activity
ISO Diclofenac affects the expression of GSTT1 mRNA
Diclofenac affects the activity of GSTT1 protein
CTD PMID:24752500 PMID:27183920 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 affects expression ISO Diclofenac affects the expression of GTF2H4 mRNA CTD PMID:24752500 NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984
JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 affects expression ISO Diclofenac affects the expression of GTF2H5 mRNA CTD PMID:24752500 NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939
JBrowse link
G Gtpbp2 GTP binding protein 2 decreases expression ISO Diclofenac results in decreased expression of GTPBP2 mRNA CTD PMID:35537566 NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Diclofenac results in increased expression of H2AX protein CTD PMID:32087850 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hamp hepcidin antimicrobial peptide affects expression
decreases secretion
ISO Diclofenac affects the expression of HAMP mRNA
Diclofenac results in decreased secretion of HAMP protein
CTD PMID:24038040 PMID:26934552 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hat1 histone acetyltransferase 1 affects expression ISO Diclofenac affects the expression of HAT1 mRNA CTD PMID:24752500 NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression
multiple interactions
increases secretion
ISO
EXP
Diclofenac results in increased expression of HAVCR1 mRNA
diacerein inhibits the reaction [Diclofenac results in increased secretion of HAVCR1 protein]
CTD PMID:23506792 PMID:38582345 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 increases expression EXP Diclofenac results in increased expression of HBA-A2 protein CTD PMID:14565772 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hbb hemoglobin subunit beta increases expression EXP Diclofenac results in increased expression of HBB protein CTD PMID:14565772 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hbegf heparin-binding EGF-like growth factor affects expression
decreases expression
increases expression
ISO Diclofenac affects the expression of HBEGF mRNA
Diclofenac results in decreased expression of HBEGF mRNA
Diclofenac results in increased expression of HBEGF mRNA
CTD PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase increases expression ISO Diclofenac results in increased expression of HCK mRNA CTD PMID:26934552 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression
increases expression
ISO Diclofenac results in decreased expression of HERC6 mRNA
Diclofenac results in increased expression of HERC6 mRNA
CTD PMID:19192274 PMID:26934552 NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 affects expression
decreases expression
ISO Diclofenac affects the expression of HERPUD1 mRNA
Diclofenac results in decreased expression of HERPUD1 mRNA
CTD PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
JBrowse link
G Hes6 hes family bHLH transcription factor 6 decreases expression ISO Diclofenac results in decreased expression of HES6 mRNA CTD PMID:26934552 NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559
JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression ISO Diclofenac results in decreased expression of HHEX mRNA CTD PMID:26934552 NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Diclofenac results in decreased expression of HIF1A protein CTD PMID:12912967 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hist1h2bc histone cluster 1, H2bc decreases expression ISO Diclofenac results in decreased expression of H2BC21 mRNA CTD PMID:26934552 NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642
JBrowse link
G Hk1 hexokinase 1 increases expression ISO Diclofenac results in increased expression of HK1 mRNA CTD PMID:26934552 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression
affects expression
EXP
ISO
Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein]
Diclofenac results in increased expression of HMGB1 mRNA; Diclofenac results in increased expression of HMGB1 protein
Diclofenac affects the expression of HMGB1 mRNA
CTD PMID:23939143 PMID:24747151 PMID:24752500 PMID:26934552 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Diclofenac results in decreased expression of HMGCS2 mRNA CTD PMID:26934552 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression
affects expression
ISO
EXP
1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac results in decreased expression of HMOX1 protein
Diclofenac results in increased expression of HMOX1 mRNA; Diclofenac results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein]
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; diacerein inhibits the reaction [Diclofenac results in decreased expression of HMOX1 protein]; Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA]; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac affects the expression of HMOX1 protein
CTD PMID:12763371 PMID:18172885 PMID:18227147 PMID:19022234 PMID:19952508 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmx3 H6 family homeobox 3 decreases expression ISO Diclofenac results in decreased expression of HMX3 mRNA CTD PMID:35537566 NCBI chr 1:186,313,237...186,315,201
Ensembl chr 1:186,313,063...186,315,201
JBrowse link
G Hnf1a HNF1 homeobox A affects expression ISO Diclofenac affects the expression of HNF1A mRNA CTD PMID:24752500 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression EXP Diclofenac results in decreased expression of HNF4A mRNA CTD PMID:19022234 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects expression ISO Diclofenac affects the expression of HNRNPD mRNA CTD PMID:24752500 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
JBrowse link
G Hoatz HOATZ cilia and flagella associated protein multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HOATZ mRNA CTD PMID:37844793 NCBI chr 8:51,385,931...51,409,796
Ensembl chr 8:51,388,382...51,412,514
JBrowse link
G Hp haptoglobin decreases expression
increases expression
ISO Diclofenac results in decreased expression of HP mRNA
Diclofenac results in increased expression of HP mRNA
CTD PMID:26934552 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity
multiple interactions
increases expression
ISO Diclofenac results in increased activity of HPGD protein
[Diclofenac co-treated with NAD] binds to HPGD protein
Diclofenac results in increased expression of HPGD mRNA
CTD PMID:19501039 PMID:25526675 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Hras HRas proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of HRAS mRNA CTD PMID:24752500 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 decreases expression ISO Diclofenac results in decreased expression of HS3ST3B1 mRNA CTD PMID:35537566 NCBI chr10:48,561,473...48,593,970
Ensembl chr10:48,561,473...48,593,970
JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 increases expression ISO Diclofenac results in increased expression of HS6ST2 mRNA CTD PMID:26934552 NCBI chr  X:130,966,547...131,261,629
Ensembl chr  X:130,968,385...131,261,492
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO Diclofenac results in decreased expression of HSD3B2 mRNA CTD PMID:26934552 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Diclofenac results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA] CTD PMID:23939143 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
affects expression
EXP
ISO
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA1A mRNA]
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HSPA1A mRNA
Diclofenac results in increased expression of HSPA1A mRNA
Diclofenac affects the expression of HSPA1A mRNA
CTD PMID:19022234 PMID:23939143 PMID:25014874 PMID:26934552 PMID:37844793 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression
multiple interactions
ISO Diclofenac results in increased expression of HSPA1B mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HSPA1B mRNA
CTD PMID:26934552 PMID:37844793 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
EXP
ISO
Diclofenac results in increased expression of HSPA5 mRNA
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HSPA5 protein
CTD PMID:25014874 PMID:25772430 PMID:27313093 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions
increases expression
EXP
ISO
Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA8 mRNA]
Diclofenac results in increased expression of HSPA8 mRNA
CTD PMID:23939143 PMID:26934552 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO Diclofenac results in decreased expression of HSPB1 mRNA CTD PMID:26934552 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression ISO Diclofenac results in increased expression of HSPB8 mRNA CTD PMID:26934552 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of IARS1 mRNA CTD PMID:35537566 NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
JBrowse link
G Ibtk inhibitor of Bruton tyrosine kinase increases expression ISO Diclofenac results in increased expression of IBTK mRNA CTD PMID:26934552 NCBI chr 8:86,625,591...86,698,661
Ensembl chr 8:86,625,597...86,698,260
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
increases expression
affects expression
EXP
ISO
Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein]
Diclofenac results in decreased expression of ICAM1 mRNA
Diclofenac results in increased expression of ICAM1 mRNA
Diclofenac affects the expression of ICAM1 mRNA
CTD PMID:14716214 PMID:18460984 PMID:24752500 PMID:26934552 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Diclofenac results in increased expression of ID2 mRNA CTD PMID:26934552 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Diclofenac results in increased expression of ID3 mRNA CTD PMID:26934552 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression ISO Diclofenac results in decreased expression of IDH2 mRNA CTD PMID:26934552 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Ier3 immediate early response 3 increases expression ISO Diclofenac results in increased expression of IER3 mRNA CTD PMID:26934552 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Diclofenac results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Diclofenac results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Diclofenac results in decreased expression of IFI44 mRNA CTD PMID:19192274 PMID:35537566 NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Diclofenac results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Diclofenac results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Diclofenac results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 increases expression ISO Diclofenac results in increased expression of IFITM2 mRNA CTD PMID:26934552 NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 increases expression ISO Diclofenac results in increased expression of IFITM3 mRNA CTD PMID:26934552 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
EXP
ISO
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]
Diclofenac results in decreased expression of IFNG mRNA
CTD PMID:19393675 PMID:22285467 PMID:23395999 PMID:23939143 PMID:26609140 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 decreases expression ISO Diclofenac results in decreased expression of IFRD1 mRNA CTD PMID:35537566 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects expression ISO Diclofenac affects the expression of IGF1R mRNA CTD PMID:24752500 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igf2r insulin-like growth factor 2 receptor multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of IGF2R mRNA CTD PMID:37844793 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 affects expression
increases expression
ISO Diclofenac affects the expression of IGFBP1 mRNA
Diclofenac results in increased expression of IGFBP1 mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO Diclofenac results in decreased expression of IGFBP2 mRNA CTD PMID:26934552 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO Diclofenac affects the expression of IGFBP3 mRNA CTD PMID:24752500 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein] CTD PMID:25935278 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO Diclofenac results in increased expression of IKBKE mRNA CTD PMID:26934552 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma affects expression ISO Diclofenac affects the expression of IKBKG mRNA CTD PMID:24752500 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Il10 interleukin 10 increases response to substance
multiple interactions
ISO
EXP
IL10 gene polymorphism results in increased susceptibility to Diclofenac
[Gum Arabic co-treated with Water deficiency co-treated with Diclofenac] results in increased expression of IL10 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]
CTD PMID:15122773 PMID:23939143 PMID:31042592 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 increases expression EXP Diclofenac results in increased expression of IL12RB1 mRNA CTD PMID:30723492 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO Diclofenac results in increased expression of IL13RA1 mRNA CTD PMID:26934552 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681
JBrowse link
G Il16 interleukin 16 decreases expression ISO Diclofenac results in decreased expression of IL16 mRNA CTD PMID:35537566 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Il17a interleukin 17A increases expression
multiple interactions
ISO
EXP
Diclofenac results in increased expression of IL17A protein
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]
CTD PMID:22285467 PMID:25450234 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
EXP diacerein inhibits the reaction [Diclofenac results in increased expression of IL18 protein] CTD PMID:38582345 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il18bp interleukin 18 binding protein increases expression ISO Diclofenac results in increased expression of IL18BP mRNA CTD PMID:26934552 NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression
ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac
Diclofenac results in increased expression of IL1A mRNA
CTD PMID:19362101 PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]
Diclofenac results in increased expression of IL1B mRNA
Diclofenac results in increased expression of IL1B mRNA; Diclofenac results in increased expression of IL1B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; diacerein inhibits the reaction [Diclofenac results in increased expression of IL1B protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
CTD PMID:15135310 PMID:15705740 PMID:19393675 PMID:22285467 PMID:23395999 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r1 interleukin 1 receptor type 1 affects expression
increases expression
ISO Diclofenac affects the expression of IL1R1 mRNA
Diclofenac results in increased expression of IL1R1 mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO
EXP
Diclofenac results in increased expression of IL1R2 mRNA CTD PMID:26934552 PMID:30723492 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression
decreases expression
increases secretion
multiple interactions
ISO Diclofenac results in increased expression of IL1RN mRNA
Diclofenac results in decreased expression of IL1RN mRNA
Diclofenac results in increased secretion of IL1RN protein
Lipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein]
CTD PMID:9491209 PMID:26934552 PMID:35537566 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Diclofenac results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il24 interleukin 24 increases expression ISO Diclofenac results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma increases expression ISO Diclofenac results in increased expression of IL2RG mRNA CTD PMID:26934552 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G Il33 interleukin 33 increases expression
decreases expression
ISO Diclofenac results in increased expression of IL33 mRNA
Diclofenac results in decreased expression of IL33 mRNA
CTD PMID:26934552 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il4 interleukin 4 increases response to substance ISO IL4 gene polymorphism results in increased susceptibility to Diclofenac CTD PMID:15122773 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions ISO Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein] CTD PMID:15663561 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression
ISO
EXP
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]; Diclofenac inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Diclofenac results in increased expression of IL6 protein]
Diclofenac results in increased expression of IL6 mRNA
Diclofenac results in decreased expression of IL6 mRNA; Diclofenac results in decreased expression of IL6 protein
Diclofenac results in increased expression of IL6 mRNA; Diclofenac results in increased expression of IL6 protein
Diclofenac inhibits the reaction [Carrageenan results in increased expression of IL6 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]
CTD PMID:19192274 PMID:19362101 PMID:23506792 PMID:23939143 PMID:24412305 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Immt inner membrane mitochondrial protein affects expression ISO Diclofenac affects the expression of IMMT mRNA CTD PMID:26934552 NCBI chr 4:103,880,482...103,919,116
Ensembl chr 4:103,880,459...103,919,109
JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO
EXP
Diclofenac results in increased expression of INHBB mRNA CTD PMID:26934552 PMID:30723492 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832
JBrowse link
G Inka2 inka box actin regulator 2 increases expression ISO Diclofenac results in increased expression of FAM212B mRNA CTD PMID:35537566 NCBI chr 2:193,185,275...193,200,643
Ensembl chr 2:193,185,275...193,200,642
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression ISO Diclofenac results in decreased expression of INMT mRNA CTD PMID:26934552 NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
JBrowse link
G Insl3 insulin-like 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of INSL3 mRNA CTD PMID:37844793 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
JBrowse link
G Insl6 insulin-like 6 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of INSL6 mRNA CTD PMID:37844793 NCBI chr 1:227,069,958...227,073,493
Ensembl chr 1:227,069,958...227,073,493
JBrowse link
G Insr insulin receptor affects expression ISO Diclofenac affects the expression of INSR mRNA CTD PMID:24752500 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Iqcf1 IQ motif containing F1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of IQCF1 mRNA CTD PMID:37844793 NCBI chr 8:107,129,462...107,133,242
Ensembl chr 8:107,130,704...107,133,249
JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 increases expression ISO Diclofenac results in increased expression of IRAK4 mRNA CTD PMID:26934552 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Diclofenac results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Irgm immunity-related GTPase M increases expression ISO Diclofenac results in increased expression of IRGM1 mRNA CTD PMID:26934552 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
JBrowse link
G Irs1 insulin receptor substrate 1 affects expression ISO Diclofenac affects the expression of IRS1 mRNA CTD PMID:24752500 PMID:26934552 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Diclofenac results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Diclofenac results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression ISO Diclofenac results in increased expression of ISYNA1 mRNA CTD PMID:26934552 NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979
JBrowse link
G Itga2 integrin subunit alpha 2 affects expression ISO Diclofenac affects the expression of ITGA2 mRNA CTD PMID:24752500 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgal integrin subunit alpha L increases expression ISO Diclofenac results in increased expression of ITGAL mRNA CTD PMID:26934552 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Diclofenac results in increased expression of ITGAM mRNA CTD PMID:27671914 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO Diclofenac results in decreased expression of ITGAX mRNA CTD PMID:35537566 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Itgb1 integrin subunit beta 1 affects expression ISO Diclofenac affects the expression of ITGB1 mRNA CTD PMID:24752500 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb2 integrin subunit beta 2 increases expression ISO Diclofenac results in increased expression of ITGB2 mRNA CTD PMID:26934552 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein] CTD PMID:19691487 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 increases expression ISO Diclofenac results in increased expression of ITIH3 mRNA CTD PMID:26934552 NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 increases expression ISO Diclofenac results in increased expression of ITIH4 mRNA CTD PMID:26934552 NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
JBrowse link
G Itm2a integral membrane protein 2A increases expression ISO Diclofenac results in increased expression of ITM2A mRNA CTD PMID:17379860 NCBI chr  X:72,486,383...72,492,344
Ensembl chr  X:72,486,381...72,492,363
JBrowse link
G Jade2 jade family PHD finger 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of JADE2 mRNA CTD PMID:37844793 NCBI chr10:36,075,239...36,124,210
Ensembl chr10:36,078,917...36,116,984
JBrowse link
G Jade3 jade family PHD finger 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of JADE3 mRNA CTD PMID:37844793 NCBI chr  X:1,668,873...1,848,781
Ensembl chr  X:1,669,930...1,845,138
JBrowse link
G Jdp2 Jun dimerization protein 2 decreases expression ISO Diclofenac results in decreased expression of JDP2 mRNA CTD PMID:35537566 NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression
increases expression
ISO Diclofenac affects the expression of JUN mRNA
Diclofenac results in increased expression of JUN mRNA
CTD PMID:24752500 PMID:26934552 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of JUNB mRNA CTD PMID:37844793 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO
EXP
Diclofenac results in increased expression of JUND mRNA CTD PMID:19022234 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Kat6b lysine acetyltransferase 6B affects expression ISO Diclofenac affects the expression of KAT6B mRNA CTD PMID:24752500 NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316
JBrowse link
G Kbtbd11 kelch repeat and BTB domain containing 11 increases expression EXP Diclofenac results in increased expression of KBTBD11 mRNA CTD PMID:30723492 NCBI chr16:74,618,291...74,638,010
Ensembl chr16:74,615,792...74,637,736
JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member increases expression EXP Diclofenac results in increased expression of KHDC3 mRNA CTD PMID:30723492 NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248
JBrowse link
G Kif5c kinesin family member 5C increases expression EXP Diclofenac results in increased expression of KIF5C mRNA CTD PMID:30723492 NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of KIT mRNA CTD PMID:37844793 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Klf4 KLF transcription factor 4 decreases expression ISO Diclofenac results in decreased expression of KLF4 mRNA CTD PMID:35537566 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klhl33 kelch-like family member 33 decreases expression ISO Diclofenac results in decreased expression of KLHL33 mRNA CTD PMID:35537566 NCBI chr15:24,105,923...24,114,445
Ensembl chr15:24,105,930...24,114,438
JBrowse link
G Klk1 kallikrein 1 increases expression ISO Diclofenac results in increased expression of KLK1 protein CTD PMID:23506792 NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754
JBrowse link
G Kndc1 kinase non-catalytic C-lobe domain containing 1 increases expression EXP Diclofenac results in increased expression of KNDC1 mRNA CTD PMID:30723492 NCBI chr 1:194,689,962...194,738,353
Ensembl chr 1:194,690,135...194,738,362
JBrowse link
G Kng1 kininogen 1 increases expression
multiple interactions
EXP Diclofenac results in increased expression of KNG1 protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of KNG1 protein; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in increased expression of KNG1 protein]
CTD PMID:25772430 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
JBrowse link
G Kras KRAS proto-oncogene, GTPase affects expression ISO Diclofenac affects the expression of KRAS mRNA CTD PMID:24752500 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lax1 lymphocyte transmembrane adaptor 1 decreases expression ISO Diclofenac results in decreased expression of LAX1 mRNA CTD PMID:26934552 NCBI chr13:45,134,825...45,145,381
Ensembl chr13:45,134,834...45,145,381
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression
decreases expression
affects expression
ISO Diclofenac results in increased expression of LBP protein
Diclofenac results in decreased expression of LBP mRNA
Diclofenac affects the expression of LBP mRNA
CTD PMID:26934552 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lcn2 lipocalin 2 increases expression
increases secretion
multiple interactions
EXP
ISO
Diclofenac results in increased expression of LCN2 mRNA
Diclofenac results in increased secretion of LCN2 protein
diacerein inhibits the reaction [Diclofenac results in increased secretion of LCN2 protein]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]
CTD PMID:23939143 PMID:26934552 PMID:38582345 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 increases expression ISO Diclofenac results in increased expression of LCP2 mRNA CTD PMID:26934552 NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559
JBrowse link
G Ldha lactate dehydrogenase A increases expression EXP Diclofenac results in increased expression of LDHA protein CTD PMID:25772430 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Leap2 liver enriched antimicrobial peptide 2 increases expression ISO Diclofenac results in increased expression of LEAP2 mRNA CTD PMID:26934552 NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244
JBrowse link
G Lepr leptin receptor affects expression
increases expression
ISO Diclofenac affects the expression of LEPR mRNA
Diclofenac results in increased expression of LEPR protein
CTD PMID:26934552 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lgals3 galectin 3 increases expression ISO Diclofenac results in increased expression of LGALS3 mRNA CTD PMID:26934552 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lgmn legumain increases expression ISO Diclofenac results in increased expression of LGMN mRNA CTD PMID:26934552 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 increases expression ISO Diclofenac results in increased expression of LGR4 mRNA CTD PMID:35537566 NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899
JBrowse link
G Lhx2 LIM homeobox 2 decreases expression ISO Diclofenac results in decreased expression of LHX2 mRNA CTD PMID:35537566 NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908
JBrowse link
G Lifr LIF receptor subunit alpha decreases expression ISO Diclofenac results in decreased expression of LIFR mRNA CTD PMID:26934552 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
JBrowse link
G Lipc lipase C, hepatic type decreases expression ISO Diclofenac results in decreased expression of LIPC mRNA CTD PMID:26934552 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression ISO Diclofenac results in increased expression of LITAF mRNA CTD PMID:26934552 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Lmnb1 lamin B1 increases expression ISO Diclofenac results in increased expression of LMNB1 mRNA CTD PMID:35537566 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Lmo4 LIM domain only 4 decreases expression ISO Diclofenac results in decreased expression of LMO4 mRNA CTD PMID:35537566 NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880
JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 decreases expression ISO Diclofenac results in decreased expression of LPAR4 mRNA CTD PMID:26934552 NCBI chr  X:72,033,486...72,046,978
Ensembl chr  X:72,033,486...72,046,977
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Diclofenac results in increased expression of LPL mRNA CTD PMID:26934552 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 increases expression ISO Diclofenac results in increased expression of LRG1 mRNA CTD PMID:26934552 NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813
JBrowse link
G Lrp8 LDL receptor related protein 8 increases expression ISO Diclofenac results in increased expression of LRP8 mRNA CTD PMID:35537566 NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352
JBrowse link
G Ltc4s leukotriene C4 synthase increases expression EXP Diclofenac results in increased expression of LTC4S mRNA CTD PMID:30723492 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Lxn latexin increases expression ISO Diclofenac results in increased expression of LXN mRNA CTD PMID:19192274 NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression
increases expression
ISO Diclofenac results in decreased expression of LY6E mRNA
Diclofenac results in increased expression of LY6E mRNA
CTD PMID:19192274 PMID:26934552 NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
JBrowse link
G Ly75 lymphocyte antigen 75 increases expression ISO Diclofenac results in increased expression of LY75 mRNA CTD PMID:26934552 NCBI chr 3:44,764,702...44,852,219
Ensembl chr 3:44,765,122...44,852,374
JBrowse link
G Lyz2 lysozyme 2 increases expression ISO Diclofenac results in increased expression of LYZ2 mRNA CTD PMID:26934552 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 affects expression ISO Diclofenac affects the expression of MAGI1 mRNA CTD PMID:24752500 NCBI chr 4:126,205,663...126,811,354
Ensembl chr 4:126,206,816...126,811,691
JBrowse link
G Malsu1 mitochondrial assembly of ribosomal large subunit 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MALSU1 mRNA CTD PMID:37844793 NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905
JBrowse link
G Maoa monoamine oxidase A affects expression ISO Diclofenac affects the expression of MAOA mRNA CTD PMID:24752500 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B affects expression ISO Diclofenac affects the expression of MAOB mRNA CTD PMID:24752500 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 affects expression ISO Diclofenac affects the expression of MAP2K3 mRNA CTD PMID:24752500 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 affects expression ISO Diclofenac affects the expression of MAP2K5 mRNA CTD PMID:24752500