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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:NMDA receptor antagonist
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Accession:CHEBI:60643 term browser browse the term
Definition:Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
Synonyms:related_synonym: N-methyl-D-aspartate receptor antagonist;   N-methyl-D-aspartate receptor antagonists;   NMDA receptor antagonists;   NMDAR antagonist;   NMDAR antagonists
 alt_id: CHEBI:60797



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    Term Annotations click to browse term
      CHEBI ontology 19874
        role 19844
          biological role 19842
            pharmacological role 19072
              antagonist 17233
                excitatory amino acid antagonist 10773
                  NMDA receptor antagonist 9308
                    (1R,2S)-nortilidine + 0
                    (2R,3S)-PPDA + 0
                    (2S,3R)-PPDA + 0
                    (R)-ketamine 0
                    (R,R)-tramadol + 38
                    (R,R)-tramadol hydrochloride + 0
                    (S,S)-tramadol + 38
                    (S,S)-tramadol hydrochloride + 0
                    2-amino-5-phosphonopentanoic acid 1
                    7-chlorokynurenic acid 1
                    CGP 78608 0
                    CGP 78608 hydrochloride 0
                    N-[2-(4-phenoxybenzyl)benzimidazol-5-yl]methanesulfonamide 0
                    N-\{2-[(4-benzylpiperidin-1-yl)methyl]benzimidazol-5-yl\}methanesulfonamide 0
                    PPDA 0
                    Ro 25-6981 1
                    Ro 25-6981 maleate 0
                    amantadine 11
                    amantadine hydrochloride 0
                    amantadine sulfate 0
                    dextromethadone + 32
                    dextromethorphan + 52
                    dinitrogen oxide 8
                    dizocilpine 3
                    dizocilpine maleate 102
                    eliprodil 1
                    esketamine + 49
                    esketamine hydrochloride 0
                    ethanol + 8821
                    ginsenoside Rb3 0
                    isoliquiritigenin + 91
                    ketamine + 966
                    ketamine hydrochloride + 0
                    kynurenic acid + 19
                    levomethadone + 32
                    memantine 32
                    memantine hydrochloride 0
                    methadone + 32
                    midafotel 0
                    noribogaine 0
                    orphenadrine + 419
                    orphenadrine citrate 0
                    orphenadrine hydrochloride 0
                    pentamidine 34
                    phencyclidine 94
                    rolicyclidine 0
                    tenocyclidine 0
                    tramadol 38
                    tramadol hydrochloride 0
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