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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methyl 5-aminolevulinate hydrochloride
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Accession:CHEBI:60641 term browser browse the term
Definition:The hydrochloride salt of methyl 5-aminolevulinate. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application results in an accumulation of protoporphyrin IX in the skin lesions to which the cream has been applied. Subsequent illumination with red light results in the generation of toxic singlet oxygen that destroys cell membranes and thereby kills the tumour cells.
Synonyms:exact_synonym: 5-methoxy-2,5-dioxopentan-1-aminium chloride
 related_synonym: Formula=C6H12ClNO3;   InChI=1S/C6H11NO3.ClH/c1-10-6(9)3-2-5(8)4-7;/h2-4,7H2,1H3;1H;   InChIKey=UJYSYPVQHFNBML-UHFFFAOYSA-N;   SMILES=[Cl-].COC(=O)CCC(=O)C[NH3+];   methyl 5-amino-4-oxopentanoate hydrochloride;   methyl 5-amino-4-oxovalerate HCl;   methyl 5-amino-4-oxovalerate hydrochloride;   methyl 5-aminolevulinate HCl;   methyl aminolevulinate HCl;   methyl aminolevulinate hydrochloride;   methyl delta-aminolevulinate HCl;   methyl delta-aminolevulinate hydrochloride
 xref: CAS:79416-27-6;   KEGG:D04988;   Reaxys:5991317


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Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pro-agent 11549
          prodrug 11293
            methyl 5-aminolevulinate hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      monocarboxylic acid 18000
                                        fatty acid 16833
                                          saturated fatty acid 16556
                                            straight-chain saturated fatty acid 16090
                                              valeric acid 14525
                                                oxopentanoic acid 30
                                                  4-oxopentanoic acid 30
                                                    5-aminolevulinic acid 30
                                                      methyl 5-aminolevulinate 0
                                                        methyl 5-aminolevulinate hydrochloride 0
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