Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isosorbide dinitrate
go back to main search page
Accession:CHEBI:6061 term browser browse the term
Definition:A glucitol derivative that has formula C6H8N2O8.
Synonyms:exact_synonym: 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol
 related_synonym: 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate;   Carvasin;   Cedocard Retard;   D-Isosorbide dinitrate;   Dianhydrosorbitol 2,5-dinitrate;   Dinitroisosorbide;   Dinitrosorbide;   Flindix;   Formula=C6H8N2O8;   InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1;   InChIKey=MOYKHGMNXAOIAT-JGWLITMVSA-N;   Isoket;   Isorbid;   Isordil;   Isosorbide 2,5-dinitrate;   Nitrosorbide;   SMILES=[H][C@]12OC[C@H](O[N+]([O-])=O)[C@@]1([H])OC[C@H]2O[N+]([O-])=O;   Sorbide nitrate;   Sorbidilat;   Sorbidnitrate;   dinitrato de isosorbida;   isosorbidi dinitras
 xref: Beilstein:88225;   CAS:87-33-2;   DrugBank:DB00883;   Drug_Central:1505;   KEGG:C07456;   KEGG:D00516
 xref_mesh: MESH:D007548


show annotations for term's descendants           Sort by:
isosorbide dinitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Isosorbide Dinitrate results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO [Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA CTD PMID:15719745 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases response to substance ISO G6PD protein results in decreased susceptibility to Isosorbide Dinitrate CTD PMID:6401899 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [Isosorbide Dinitrate co-treated with Ascorbic Acid] affects the expression of NOS3 mRNA; [Isosorbide Dinitrate co-treated with Plant Preparations] results in increased expression of NOS3 mRNA CTD PMID:15719745 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      chemical role 19498
        donor 18950
          nitric oxide donor 2784
            isosorbide dinitrate 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  carbohydrates and carbohydrate derivatives 15308
                                    carbohydrate 15308
                                      alditol 3311
                                        hexitol 134
                                          glucitol 46
                                            glucitol derivative 5
                                              isosorbide dinitrate 4
paths to the root