Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:opioid agent
go back to main search page
Accession:CHEBI:60598 term browser browse the term
Definition:Any agent that acts on an opioid receptor or affects the life cycle of an opioid transmitter.
Synonyms:related_synonym: opioid agents



show annotations for term's descendants           Sort by:
(R,R)-tramadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases expression EXP Tramadol results in increased expression of ADRA1A protein CTD PMID:15464068 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein] CTD PMID:31618080 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Tramadol results in increased expression of BAX protein CTD PMID:25550769 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Tramadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Casp3 caspase 3 affects activity
multiple interactions
increases expression
decreases activity
ISO
EXP
Tramadol affects the activity of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein
CTD PMID:27317026 PMID:28499616 PMID:31618080 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
CTD PMID:25550769 PMID:31618080 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ckb creatine kinase B decreases expression
multiple interactions
ISO
EXP
Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
CTD PMID:27317026 PMID:33645892 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein] CTD PMID:33645892 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Tramadol results in decreased activity of CYP17A1 protein CTD PMID:29100959 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing
ISO CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CTD PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Des desmin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of DES protein] CTD PMID:33645892 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Tramadol results in increased expression of DRD2 protein CTD PMID:15464068 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Tramadol results in increased expression of DRD3 protein CTD PMID:15464068 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein] CTD PMID:33645892 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein] CTD PMID:31618080 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
increases expression
EXP Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]
CTD PMID:28689766 PMID:31618080 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases activity
increases expression
multiple interactions
EXP Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
CTD PMID:18417104 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Ifng interferon gamma multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein] CTD PMID:33645892 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Tramadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Tramadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding
multiple interactions
EXP Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO Tramadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:58,486,699...58,553,533
Ensembl chr  X:58,486,554...58,553,557
JBrowse link
G Pdyn prodynorphin decreases expression EXP Tramadol results in decreased expression of PDYN mRNA CTD PMID:17401159 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA CTD PMID:31276069 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA CTD PMID:31276069 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:11723065 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
CTD PMID:25550769 PMID:31618080 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
EXP Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA
CTD PMID:25550769 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
EXP Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein] CTD PMID:33645892 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP [Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein] CTD PMID:17377112 PMID:31618080 PMID:33645892 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions
increases expression
EXP Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein] CTD PMID:33645892 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Vim vimentin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein] CTD PMID:33645892 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
alfentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A multiple interactions ISO CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]; CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil] CTD PMID:15557344 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
multiple interactions
ISO CYP3A4 protein affects the metabolism of Alfentanil
CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]
CTD PMID:15557344 PMID:15731592 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
affects metabolic processing
ISO CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil] CTD PMID:15557344 PMID:15731592 PMID:17554244 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Alfentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
buprenorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor decreases expression EXP Buprenorphine results in decreased expression of BDNF protein CTD PMID:24321744 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Buprenorphine results in decreased activity of CAT protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Buprenorphine] results in increased activity of CAT protein
CTD PMID:25683329 PMID:32113805 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of CREB1 protein CTD PMID:24321744 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing ISO CYP2C8 protein affects the metabolism of Buprenorphine CTD PMID:16010532
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
ISO CYP2D6 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP2D6 protein
CTD PMID:12756210 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
decreases alkylation
increases metabolic processing
decreases activity
ISO CYP3A4 protein affects the metabolism of Buprenorphine
CYP3A4 protein results in decreased alkylation of Buprenorphine
CYP3A4 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP3A4 protein
CTD PMID:12756210 PMID:15966752 PMID:16010532 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Buprenorphine results in increased activity of GPT protein CTD PMID:25683329 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Il2 interleukin 2 decreases expression ISO Buprenorphine results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression ISO Buprenorphine results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of NTRK2 protein CTD PMID:24321744 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP
ISO
Buprenorphine binds to OPRD1 protein
Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]
CTD PMID:7562497 PMID:21866885 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP
ISO
Buprenorphine binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]
CTD PMID:7562497 PMID:21866885 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO Buprenorphine binds to and results in increased activity of OPRL1 protein CTD PMID:10998549 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
Buprenorphine binds to and affects the activity of OPRM1 protein; Buprenorphine binds to and results in increased activity of OPRM1 protein; Buprenorphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]
Buprenorphine binds to OPRM1 protein
CTD PMID:7562497 PMID:16010532 PMID:21866885 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases activity EXP Buprenorphine results in decreased activity of PRKACA protein CTD PMID:24321744 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Buprenorphine CTD PMID:12756209 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
butorphanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects activity EXP Butorphanol affects the activity of OPRD1 protein CTD PMID:17909753 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity EXP Butorphanol affects the activity of OPRK1 protein CTD PMID:17909753 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects activity
increases activity
ISO
EXP
Butorphanol affects the activity of OPRM1 protein
Butorphanol results in increased activity of OPRM1 protein
CTD PMID:17909753 PMID:32734307 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Butorphanol affects the localization of PRKCD protein CTD PMID:29669290 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
JBrowse link
carfentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of carfentanil CTD PMID:33652071
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of carfentanil CTD PMID:33652071 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of carfentanil CTD PMID:33652071 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO Capsaicin inhibits the reaction [carfentanil binds to OPRM1 protein]; Cocaine affects the reaction [carfentanil binds to OPRM1 protein] CTD PMID:12406535 PMID:15953495 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
codeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Codeine results in increased secretion of CCL2 protein CTD PMID:17441793 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Codeine affects the secretion of and affects the expression of CCL5 protein CTD PMID:17441793 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Codeine analog CTD PMID:25445008 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
multiple interactions
increases metabolic processing
affects response to substance
decreases methylation
ISO CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine
[CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
[CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CYP2D6 protein polymorphism affects the susceptibility to Codeine
CYP2D6 protein results in decreased methylation of Codeine
CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine
CTD PMID:9696456 PMID:10911933 PMID:11823760 PMID:15286053 PMID:15625333 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP3A4 protein affects the metabolism of Codeine
CYP3A4 protein results in increased metabolism of Codeine
[CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CTD PMID:15286053 PMID:16595712 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Codeine results in decreased activity of KCNH2 protein CTD PMID:19034038 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Codeine binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Codeine binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Codeine binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
codeinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 6-codeinone results in increased expression of BAX protein CTD PMID:12894543 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 6-codeinone results in decreased expression of BCL2 protein CTD PMID:12894543 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO 6-codeinone results in increased activity of CASP3 protein
6-codeinone results in increased cleavage of CASP3 protein
CTD PMID:12606908 PMID:12894543 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO 6-codeinone results in increased activity of CASP9 protein CTD PMID:12894543 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 6-codeinone affects the localization of CYCS protein CTD PMID:12894543 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
dextropropoxyphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Ces1d carboxylesterase 1D affects binding ISO Dextropropoxyphene binds to CES1 protein CTD PMID:10381793 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Dextropropoxyphene binds to CES2 protein CTD PMID:10381793 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dextropropoxyphene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
DPDPE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects export EXP ABCC2 protein affects the export of Enkephalin, D-Penicillamine (2,5)- CTD PMID:15528320 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Enkephalin, D-Penicillamine (2,5)- CTD PMID:11880531 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases secretion ISO HNF4A protein results in increased secretion of Enkephalin, D-Penicillamine (2,5)- CTD PMID:27160211 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding
increases expression
EXP
ISO
[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum; [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine; naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine]
7-hydroxymitragynine affects the reaction [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein]; Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]; Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein
Enkephalin, D-Penicillamine (2,5)- binds to OPRD1 protein
Enkephalin, D-Penicillamine (2,5)- results in increased expression of OPRD1 mRNA
CTD PMID:7477890 PMID:7562497 PMID:9302088 PMID:19279569 PMID:21866885 More... NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Enkephalin, D-Penicillamine (2,5)- binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Enkephalin, D-Penicillamine (2,5)- binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects transport
affects uptake
ISO
EXP
SLCO1A4 protein affects the transport of Enkephalin, D-Penicillamine (2,5)-
SLCO1A4 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)-
CTD PMID:15528320 PMID:19833843 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects uptake EXP SLCO1B2 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)- CTD PMID:15528320 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
eluxadoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to eluxadoline CTD PMID:25261794 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
fentanyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
increases response to substance
ISO
EXP
ABCB1 protein results in increased transport of Fentanyl
tariquidar inhibits the reaction [ABCB1 protein results in increased transport of Fentanyl]
ABCB1 protein results in increased susceptibility to Fentanyl
CTD PMID:29669042 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acan aggrecan decreases expression EXP Fentanyl results in decreased expression of ACAN mRNA CTD PMID:36032789 NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 decreases expression EXP Fentanyl results in decreased expression of ADAMTS14 mRNA CTD PMID:36032789 NCBI chr20:29,143,029...29,219,846
Ensembl chr20:29,144,354...29,219,866
JBrowse link
G Adamtsl3 ADAMTS-like 3 affects expression EXP Fentanyl affects the expression of ADAMTSL3 mRNA CTD PMID:36032789 NCBI chr 1:136,288,793...136,596,986
Ensembl chr 1:136,288,793...136,596,986
JBrowse link
G Akap5 A-kinase anchoring protein 5 increases expression EXP Fentanyl results in increased expression of AKAP5 mRNA CTD PMID:36032789 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
JBrowse link
G Apln apelin decreases expression EXP Fentanyl results in decreased expression of APLN mRNA CTD PMID:36032789 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G Arrb2 arrestin, beta 2 affects localization
multiple interactions
ISO
EXP
Fentanyl affects the localization of ARRB2 protein
[Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein
CTD PMID:27030709 PMID:35477798 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Bdnf brain-derived neurotrophic factor affects expression EXP Fentanyl affects the expression of BDNF mRNA CTD PMID:36032789 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bgn biglycan affects expression EXP Fentanyl affects the expression of BGN mRNA CTD PMID:36032789 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression EXP Fentanyl results in increased expression of BIRC3 mRNA CTD PMID:36032789 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression EXP Fentanyl results in increased expression of BST2 mRNA CTD PMID:36032789 NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G C3 complement C3 increases expression EXP Fentanyl results in increased expression of C3 mRNA CTD PMID:36032789 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E affects expression EXP Fentanyl affects the expression of CACNA1E mRNA CTD PMID:36032789 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]] CTD PMID:27030709 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Cckbr cholecystokinin B receptor decreases expression EXP Fentanyl results in decreased expression of CCKBR mRNA CTD PMID:36032789 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Fentanyl results in increased expression of CCL2 mRNA CTD PMID:36032789 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression EXP Fentanyl results in increased expression of CCL20 mRNA CTD PMID:36032789 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP Fentanyl results in increased expression of CCL7 mRNA CTD PMID:36032789 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Cfb complement factor B increases expression EXP Fentanyl results in increased expression of CFB mRNA CTD PMID:36032789 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Chi3l1 chitinase 3 like 1 increases expression EXP Fentanyl results in increased expression of CHI3L1 mRNA CTD PMID:36032789 NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787
JBrowse link
G Clstn2 calsyntenin 2 affects expression EXP Fentanyl affects the expression of CLSTN2 mRNA CTD PMID:36032789 NCBI chr 8:98,020,406...98,637,232
Ensembl chr 8:98,021,666...98,637,731
JBrowse link
G Cntf ciliary neurotrophic factor increases expression EXP Fentanyl results in increased expression of CNTF mRNA CTD PMID:36032789 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
JBrowse link
G Col15a1 collagen type XV alpha 1 chain increases expression EXP Fentanyl results in increased expression of COL15A1 mRNA CTD PMID:36032789 NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591
JBrowse link
G Col26a1 collagen type XXVI alpha 1 chain increases expression EXP Fentanyl results in increased expression of COL26A1 mRNA CTD PMID:36032789 NCBI chr12:19,792,693...19,938,556
Ensembl chr12:19,792,728...19,938,556
JBrowse link
G Col3a1 collagen type III alpha 1 chain affects expression EXP Fentanyl affects the expression of COL3A1 mRNA CTD PMID:36032789 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Crh corticotropin releasing hormone affects expression
increases expression
EXP Fentanyl affects the expression of CRH mRNA
Fentanyl results in increased expression of CRH mRNA
CTD PMID:18819432 PMID:36032789 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crlf1 cytokine receptor-like factor 1 affects expression EXP Fentanyl affects the expression of CRLF1 mRNA CTD PMID:36032789 NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997
JBrowse link
G Csf1 colony stimulating factor 1 increases expression EXP Fentanyl results in increased expression of CSF1 mRNA CTD PMID:36032789 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Fentanyl results in increased expression of CXCL1 mRNA CTD PMID:36032789 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP Fentanyl results in increased expression of CXCL10 mRNA CTD PMID:36032789 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression EXP Fentanyl results in increased expression of CXCL11 mRNA CTD PMID:36032789 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression EXP Fentanyl results in increased expression of CXCL12 mRNA CTD PMID:36032789 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression EXP Fentanyl results in increased expression of CXCL13 mRNA CTD PMID:36032789 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 increases expression EXP Fentanyl results in increased expression of CXCL16 mRNA CTD PMID:36032789 NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity ISO Fentanyl results in increased activity of CYP2B6 protein CTD PMID:35914676 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Fentanyl CTD PMID:11811955 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dcn decorin increases expression EXP Fentanyl results in increased expression of DCN mRNA CTD PMID:36032789 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Ednrb endothelin receptor type B decreases expression EXP Fentanyl results in decreased expression of EDNRB mRNA CTD PMID:36032789 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Fbln5 fibulin 5 decreases expression EXP Fentanyl results in decreased expression of FBLN5 mRNA CTD PMID:36032789 NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase increases expression EXP Fentanyl results in increased expression of FGR mRNA CTD PMID:36032789 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Fentanyl results in increased expression of FOS protein CTD PMID:7970238 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gast gastrin multiple interactions EXP [fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gbp2 guanylate binding protein 2 increases expression EXP Fentanyl results in increased expression of GBP2 mRNA CTD PMID:36032789 NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist decreases expression EXP Fentanyl results in decreased expression of GREM1 mRNA CTD PMID:36032789 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects expression EXP Fentanyl affects the expression of GRIN2A mRNA CTD PMID:36032789 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects expression EXP Fentanyl affects the expression of GRIN2B mRNA CTD PMID:36032789 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grm1 glutamate metabotropic receptor 1 affects expression EXP Fentanyl affects the expression of GRM1 mRNA CTD PMID:36032789 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Grm3 glutamate metabotropic receptor 3 affects expression EXP Fentanyl affects the expression of GRM3 mRNA CTD PMID:36032789 NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804
JBrowse link
G Has1 hyaluronan synthase 1 decreases expression EXP Fentanyl results in decreased expression of HAS1 mRNA CTD PMID:36032789 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397
JBrowse link
G Hcrtr1 hypocretin receptor 1 decreases expression EXP Fentanyl results in decreased expression of HCRTR1 mRNA CTD PMID:36032789 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects expression EXP Fentanyl affects the expression of HTR2A mRNA CTD PMID:36032789 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression EXP Fentanyl results in increased expression of IFIT3 mRNA CTD PMID:36032789 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Fentanyl results in increased expression of IL1A mRNA CTD PMID:36032789 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il2 interleukin 2 decreases expression ISO Fentanyl results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression ISO Fentanyl results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il7 interleukin 7 increases expression EXP Fentanyl results in increased expression of IL7 mRNA CTD PMID:36032789 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Irf7 interferon regulatory factor 7 increases expression EXP Fentanyl results in increased expression of IRF7 mRNA CTD PMID:36032789 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression EXP Fentanyl results in increased expression of ISG15 mRNA CTD PMID:36032789 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Itga11 integrin subunit alpha 11 increases expression EXP Fentanyl results in increased expression of ITGA11 mRNA CTD PMID:36032789 NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407
JBrowse link
G Itgal integrin subunit alpha L increases expression EXP Fentanyl results in increased expression of ITGAL mRNA CTD PMID:36032789 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fentanyl results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression EXP Fentanyl results in decreased expression of LAMB3 mRNA CTD PMID:36032789 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
JBrowse link
G Lamc2 laminin subunit gamma 2 affects expression EXP Fentanyl affects the expression of LAMC2 mRNA CTD PMID:36032789 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Fentanyl results in increased expression of LCN2 mRNA CTD PMID:36032789 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lox lysyl oxidase decreases expression EXP Fentanyl results in decreased expression of LOX mRNA CTD PMID:36032789 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Loxl1 lysyl oxidase-like 1 increases expression EXP Fentanyl results in increased expression of LOXL1 mRNA CTD PMID:36032789 NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356
JBrowse link
G Loxl2 lysyl oxidase-like 2 decreases expression EXP Fentanyl results in decreased expression of LOXL2 mRNA CTD PMID:36032789 NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067
JBrowse link
G Ltb lymphotoxin beta increases expression EXP Fentanyl results in increased expression of LTB mRNA CTD PMID:36032789 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Fentanyl results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Fentanyl results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor decreases expression EXP Fentanyl results in decreased expression of MAS1 mRNA CTD PMID:36032789 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP Fentanyl results in increased expression of MMP2 mRNA CTD PMID:36032789 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP Fentanyl results in decreased expression of MMP9 mRNA CTD PMID:36032789 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mx1 MX dynamin like GTPase 1 increases expression EXP Fentanyl results in increased expression of MX1 mRNA CTD PMID:36032789 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Mx2 MX dynamin like GTPase 2 increases expression EXP Fentanyl results in increased expression of MX2 mRNA CTD PMID:36032789 NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO
EXP
Fentanyl results in increased expression of NFKBIA protein
Fentanyl results in increased expression of NFKBIA mRNA
CTD PMID:22258905 PMID:36032789 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nid2 nidogen 2 decreases expression EXP Fentanyl results in decreased expression of NID2 mRNA CTD PMID:36032789 NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843
JBrowse link
G Nppc natriuretic peptide C affects expression EXP Fentanyl affects the expression of NPPC mRNA CTD PMID:36032789 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
JBrowse link
G Nts neurotensin decreases expression EXP Fentanyl results in decreased expression of NTS mRNA CTD PMID:36032789 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP Fentanyl results in increased expression of OASL mRNA CTD PMID:36032789 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Fentanyl binds to OPRD1 protein CTD PMID:35477798 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Fentanyl binds to OPRK1 protein CTD PMID:35477798 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 increases phosphorylation
multiple interactions
ISO
EXP
Fentanyl results in increased phosphorylation of OPRM1 protein
[Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Fentanyl binds to and results in increased activity of OPRM1 protein
CTD PMID:17240843 PMID:21957251 PMID:23300227 PMID:35477798 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 decreases expression EXP Fentanyl results in decreased expression of P4HA2 mRNA CTD PMID:36032789 NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,243,139...38,287,314
JBrowse link
G Pdyn prodynorphin increases expression EXP Fentanyl results in increased expression of PDYN protein CTD PMID:19200067 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Pf4 platelet factor 4 increases expression EXP Fentanyl results in increased expression of PF4 mRNA CTD PMID:36032789 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Fentanyl results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions
ISO Fentanyl results in decreased expression of POMC protein alternative form
[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form
CTD PMID:20084599 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prlhr prolactin releasing hormone receptor decreases expression EXP Fentanyl results in decreased expression of PRLHR mRNA CTD PMID:36032789 NCBI chr 1:259,606,704...259,608,391
Ensembl chr 1:259,606,704...259,608,391
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 increases expression EXP Fentanyl results in increased expression of PSMB9 mRNA CTD PMID:36032789 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
JBrowse link
G Pthlh parathyroid hormone-like hormone affects expression EXP Fentanyl affects the expression of PTHLH mRNA CTD PMID:36032789 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptx3 pentraxin 3 increases expression EXP Fentanyl results in increased expression of PTX3 mRNA CTD PMID:36032789 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Reln reelin increases expression EXP Fentanyl results in increased expression of RELN mRNA CTD PMID:36032789 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Ren renin multiple interactions ISO [Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein CTD PMID:3284271 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Fentanyl results in increased expression of S100A8 mRNA CTD PMID:36032789 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G Scg2 secretogranin II affects expression EXP Fentanyl affects the expression of SCG2 mRNA CTD PMID:36032789 NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097
JBrowse link
G Sema3a semaphorin 3A decreases expression EXP Fentanyl results in decreased expression of SEMA3A mRNA CTD PMID:36032789 NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432
JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression EXP Fentanyl results in increased expression of SLC11A1 mRNA CTD PMID:36032789 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101
JBrowse link
G Slc8a2 solute carrier family 8 member A2 affects expression EXP Fentanyl affects the expression of SLC8A2 mRNA CTD PMID:36032789 NCBI chr 1:76,816,583...76,852,928
Ensembl chr 1:76,808,725...76,847,072
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Fentanyl results in increased expression of SOD2 mRNA CTD PMID:36032789 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sorcs3 sortilin-related VPS10 domain containing receptor 3 decreases expression EXP Fentanyl results in decreased expression of SORCS3 mRNA CTD PMID:36032789 NCBI chr 1:247,099,178...247,734,027
Ensembl chr 1:247,099,408...247,734,027
JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression EXP Fentanyl affects the expression of SPP1 mRNA CTD PMID:36032789 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tlr2 toll-like receptor 2 increases expression EXP Fentanyl results in increased expression of TLR2 mRNA CTD PMID:36032789 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression EXP Fentanyl results in increased expression of TNFRSF9 mRNA CTD PMID:36032789 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Fentanyl results in increased expression of VCAM1 mRNA CTD PMID:36032789 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP Fentanyl results in decreased expression of VEGFA mRNA CTD PMID:36032789 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vgf VGF nerve growth factor inducible affects expression EXP Fentanyl affects the expression of VGF mRNA CTD PMID:36032789 NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
JBrowse link
G Wnt10a Wnt family member 10A affects expression EXP Fentanyl affects the expression of WNT10A mRNA CTD PMID:36032789 NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400
JBrowse link
heroin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases metabolic processing
ISO [ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Actn2 actinin alpha 2 decreases expression ISO Heroin results in decreased expression of ACTN2 mRNA CTD PMID:16710320 NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622
JBrowse link
G Amph amphiphysin decreases expression ISO Heroin results in decreased expression of AMPH mRNA CTD PMID:16710320 NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Heroin results in decreased expression of APP mRNA CTD PMID:16710320 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases metabolic processing
ISO [BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
ISO
EXP
Heroin results in decreased expression of BDNF protein
Heroin results in decreased expression of BDNF mRNA
Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
CTD PMID:17715210 PMID:25643298 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 decreases expression ISO Heroin results in decreased expression of BLOC1S6 mRNA CTD PMID:16710320 NCBI chr 3:109,816,397...109,826,528
Ensembl chr 3:109,816,366...109,828,308
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein] CTD PMID:20600547 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ces1d carboxylesterase 1D decreases acetylation
increases hydrolysis
multiple interactions
affects binding
ISO CES1 protein results in decreased acetylation of Heroin
CES1 protein results in increased hydrolysis of Heroin
Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
Heroin binds to CES1 protein
CTD PMID:8930175 PMID:9311626 PMID:12679808 PMID:12773168 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis
ISO Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin] CTD PMID:8930175 PMID:9169443 PMID:25445008 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO Heroin results in decreased expression of CHURC1 mRNA CTD PMID:16710320 NCBI chr 6:95,464,488...95,485,208
Ensembl chr 6:95,470,683...95,619,586
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
heroin increases phosphorylation of Creb1 protein in brain
CTD
RGD
PMID:25643298 PMID:21362452 RGD:401901181 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Heroin results in decreased activity of CYP1A2 protein CTD PMID:35914676 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity ISO Heroin results in increased activity of CYP2B6 protein CTD PMID:35914676 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases activity ISO Heroin results in increased activity of CYP2D6 protein CTD PMID:35914676 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression ISO Heroin results in decreased expression of DEAF1 mRNA CTD PMID:16710320 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO Heroin results in decreased expression of DNPH1 mRNA CTD PMID:16710320 NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO Heroin results in decreased expression of DRD2 protein CTD PMID:11126397 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A decreases expression ISO Heroin results in decreased expression of EIF5A mRNA CTD PMID:16710320 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
JBrowse link
G Enho energy homeostasis associated decreases expression ISO Heroin results in decreased expression of ENHO mRNA CTD PMID:16710320 NCBI chr 5:56,800,980...56,802,777
Ensembl chr 5:56,800,980...56,802,777
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Heroin results in increased expression of FAS mRNA CTD PMID:16710320 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Heroin results in increased expression of FOS mRNA; Heroin results in increased expression of FOS protein
Dronabinol affects the reaction [Heroin results in increased expression of FOS protein]
CTD PMID:16137723 PMID:19169671 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP heroin decreases expression of Fosb protein in brain RGD PMID:21362452 RGD:401901181 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heroin results in increased expression of GPT protein CTD PMID:36502556 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IFNG protein CTD PMID:16766138 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL10 protein CTD PMID:16766138 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL2 protein CTD PMID:16766138 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 increases expression ISO Heroin results in increased expression of ITGB1BP1 mRNA CTD PMID:16710320 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
JBrowse link
G Ngf nerve growth factor decreases expression ISO Heroin results in decreased expression of NGF protein CTD PMID:17715210 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP Heroin results in decreased expression of NR4A2 mRNA CTD PMID:25643298 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Heroin results in increased expression of NTRK2 mRNA CTD PMID:16710320 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 decreases expression ISO Heroin results in decreased expression of NUCKS1 mRNA CTD PMID:16710320 NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO Heroin results in increased expression of PDE4DIP mRNA CTD PMID:16710320 NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379
JBrowse link
G Pdyn prodynorphin decreases expression
increases expression
ISO
EXP
Heroin results in decreased expression of PDYN mRNA
Heroin results in increased expression of PDYN mRNA
CTD PMID:16710320 PMID:19100723 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO Heroin results in decreased expression of PMEPA1 mRNA CTD PMID:16710320 NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
JBrowse link
G Prepl prolyl endopeptidase-like decreases expression ISO Heroin results in decreased expression of PREPL mRNA CTD PMID:16710320 NCBI chr 6:9,580,367...9,609,957
Ensembl chr 6:9,580,217...9,607,772
JBrowse link
G Septin4 septin 4 increases expression ISO Heroin results in increased expression of SEPTIN4 mRNA CTD PMID:16710320 NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768
JBrowse link
G Slc25a23 solute carrier family 25 member 23 decreases expression ISO Heroin results in decreased expression of SLC25A23 mRNA CTD PMID:16710320 NCBI chr 9:1,882,636...1,898,369
Ensembl chr 9:1,882,621...1,898,561
JBrowse link
G Slc25a37 solute carrier family 25 member 37 increases expression ISO Heroin results in increased expression of SLC25A37 mRNA CTD PMID:16710320 NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
JBrowse link
G Snap25 synaptosome associated protein 25 decreases expression ISO Heroin results in decreased expression of SNAP25 mRNA CTD PMID:16710320 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO Heroin results in decreased expression of STXBP1 mRNA CTD PMID:16710320 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Stxbp6 syntaxin binding protein 6 decreases expression ISO Heroin results in decreased expression of STXBP6 mRNA CTD PMID:16710320 NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a decreases expression ISO Heroin results in decreased expression of SV2A mRNA CTD PMID:16710320 NCBI chr 2:183,741,489...183,757,290
Ensembl chr 2:183,741,547...183,756,927
JBrowse link
G Syngr3 synaptogyrin 3 decreases expression ISO Heroin results in decreased expression of SYNGR3 mRNA CTD PMID:16710320 NCBI chr10:13,710,553...13,715,309
Ensembl chr10:13,704,998...13,715,669
JBrowse link
G Syt1 synaptotagmin 1 decreases expression ISO Heroin results in decreased expression of SYT1 mRNA CTD PMID:16710320 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
G Tfrc transferrin receptor increases expression ISO Heroin results in increased expression of TFRC mRNA CTD PMID:16710320 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of TNF protein CTD PMID:16766138 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO Heroin results in decreased expression of UGCG mRNA CTD PMID:16710320 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
JBrowse link
G Vti1b vesicle transport through interaction with t-SNAREs 1B decreases expression ISO Heroin results in decreased expression of VTI1B mRNA CTD PMID:16710320 NCBI chr 6:97,957,700...97,976,491
Ensembl chr 6:97,961,346...97,976,465
JBrowse link
hydrocodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects binding EXP Hydrocodone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Hydrocodone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Hydrocodone binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
hydromorphone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions EXP [Hydromorphone binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein CTD PMID:35449307 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Hydromorphone affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity
multiple interactions
ISO
EXP
Hydromorphone results in increased activity of OPRM1 protein
[Hydromorphone binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Hydromorphone binds to and results in increased activity of OPRM1 protein
CTD PMID:32734307 PMID:35449307 PMID:35477798 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp3 dipeptidylpeptidase 3 increases cleavage
multiple interactions
ISO DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]
CTD PMID:10873616 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Loperamide results in decreased expression of ABCB11 mRNA CTD PMID:35926757 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
decreases expression
multiple interactions
increases transport
affects response to substance
ISO Loperamide binds to ABCB1 protein
Loperamide results in decreased expression of ABCB1 mRNA
Loperamide inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]
ABCB1 protein results in increased transport of Loperamide
ABCB1A protein affects the susceptibility to Loperamide
CTD PMID:15502009 PMID:23976943 PMID:34719826 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Loperamide CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Loperamide results in decreased expression of ABCC2 mRNA CTD PMID:35926757 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO Loperamide results in decreased expression of ABCG5 mRNA CTD PMID:35926757 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Ano1 anoctamin 1 decreases expression
multiple interactions
ISO Loperamide results in decreased expression of ANO1 mRNA; Loperamide results in decreased expression of ANO1 protein
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 protein]
CTD PMID:37375548 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]
Loperamide results in decreased expression of BCL2 mRNA
CTD PMID:34719826 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Cat catalase decreases expression EXP Loperamide results in decreased expression of CAT protein CTD PMID:30597669 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Loperamide results in increased expression of CDKN1A mRNA
Loperamide promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]
CTD PMID:34719826 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ces2h carboxylesterase 2H decreases activity
multiple interactions
ISO Loperamide results in decreased activity of CES2 protein
[Loperamide results in decreased activity of CES2 protein] which results in increased susceptibility to Bisphenol A-Glycidyl Methacrylate
CTD PMID:15687373 PMID:21951919 PMID:28647665 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Ch25h cholesterol 25-hydroxylase increases expression ISO Loperamide results in increased expression of CH25H mRNA CTD PMID:35926757 NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195
JBrowse link
G Ckb creatine kinase B multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Loperamide results in increased expression of CYP7A1 mRNA CTD PMID:35926757 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression ISO Loperamide results in increased expression of FABP6 mRNA CTD PMID:35926757 NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression ISO Loperamide results in increased expression of FDPS mRNA CTD PMID:35926757 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases secretion EXP Loperamide results in increased secretion of GOT1 protein CTD PMID:30597669 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Loperamide results in increased expression of HMGCR mRNA CTD PMID:35926757 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions
decreases expression
ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA] CTD PMID:37375548 NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Loperamide results in increased expression of IDI1 mRNA CTD PMID:35926757 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Il2 interleukin 2 decreases expression ISO Loperamide results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression ISO Loperamide results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Lss lanosterol synthase increases expression ISO Loperamide results in increased expression of LSS mRNA CTD PMID:35926757 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
multiple interactions
ISO Loperamide results in decreased expression of MAPK8 mRNA
Loperamide promotes the reaction [Doxorubicin results in decreased expression of MAPK8 mRNA]
CTD PMID:34719826 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression
ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of MTOR mRNA]
Loperamide results in decreased expression of MTOR mRNA
CTD PMID:34719826 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mvk mevalonate kinase increases expression ISO Loperamide results in increased expression of MVK mRNA CTD PMID:35926757 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Mylk myosin light chain kinase decreases expression
multiple interactions
ISO Loperamide results in decreased expression of MYLK mRNA
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA]
CTD PMID:37375548 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Loperamide results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of NOS1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of NOS1 protein] CTD PMID:37375548 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Loperamide binds to and results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to Loperamide CTD PMID:25261794 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Loperamide results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Ryr3 ryanodine receptor 3 decreases expression
multiple interactions
ISO Loperamide results in decreased expression of RYR3 mRNA
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA]
CTD PMID:37375548 NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Loperamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc51a solute carrier family 51 member A increases expression ISO Loperamide results in increased expression of SLC51A mRNA CTD PMID:35926757 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
JBrowse link
G Sqle squalene epoxidase increases expression ISO Loperamide results in increased expression of SQLE mRNA CTD PMID:35926757 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion EXP Loperamide results in increased secretion of TNNI3 protein CTD PMID:30597669 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 multiple interactions
decreases expression
ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of TRPM7 protein] CTD PMID:37375548 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
JBrowse link
methadone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
affects activity
ISO Methadone results in increased expression of ABCB1 protein
Methadone affects the activity of ABCB1 protein
CTD PMID:19840843 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects activity
increases expression
EXP Methadone affects the activity of ABCB1B protein
Methadone results in increased expression of ABCB1B protein
CTD PMID:19840843 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO Methadone affects the localization of BAX protein CTD PMID:20691259 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP Methadone results in increased secretion of CCL2 protein CTD PMID:20178837 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion EXP Methadone results in increased secretion of CCL3 protein CTD PMID:20178837 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases secretion EXP Methadone results in increased secretion of CX3CL1 protein CTD PMID:20178837 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion EXP Methadone results in increased secretion of CXCL1 protein CTD PMID:20178837 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Methadone affects the localization of CYCS protein CTD PMID:20691259 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
affects metabolic processing
ISO Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone] CTD PMID:15242824 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
ISO CYP2D22 protein results in increased metabolism of Methadone
Methadone results in decreased activity of CYP2D6 protein
CTD PMID:16595712 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
ISO CYP3A4 protein affects the metabolism of Methadone
CYP3A4 protein results in increased metabolism of Methadone
CTD PMID:15986265 PMID:16595712 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA] CTD PMID:18990547 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions EXP Methadone affects the reaction [Cocaine affects the expression of HCRT mRNA] CTD PMID:18990547 NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210
JBrowse link
G Il10 interleukin 10 increases secretion EXP Methadone results in increased secretion of IL10 protein CTD PMID:20178837 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Methadone results in increased expression of IL1A protein CTD PMID:20178837 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
EXP Methadone results in increased secretion of IL1B protein
Methadone results in increased expression of IL1B protein
CTD PMID:20178837 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 decreases expression ISO Methadone results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions
ISO Methadone results in increased expression of IL4 mRNA; Methadone results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Methadone results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Methadone results in increased expression of IL4 mRNA]
CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
EXP Methadone results in increased expression of IL6 mRNA; Methadone results in increased expression of IL6 protein
Methadone results in increased secretion of IL6 protein
CTD PMID:20178837 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 decreases response to substance ISO Methadone results in decreased susceptibility to INS protein CTD PMID:2554359 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Chlorobutanol promotes the reaction [Methadone results in decreased activity of KCNH2 protein] CTD PMID:14527710 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lep leptin increases expression ISO Methadone results in increased expression of LEP protein CTD PMID:15717844 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Methadone results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Methadone results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Methadone results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Methadone binds to OPRD1 protein
[Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Methadone binds to OPRK1 protein
[Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Methadone results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Prl prolactin affects secretion
increases secretion
increases expression
ISO Methadone affects the secretion of PRL protein
Methadone results in increased secretion of PRL protein
Methadone results in increased expression of PRL protein
CTD PMID:2554359 PMID:16675813 PMID:21094671 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Tlr4 toll-like receptor 4 affects binding
increases expression
affects response to substance
multiple interactions
ISO
EXP
Methadone binds to TLR4 protein
Methadone results in increased expression of TLR4 mRNA; Methadone results in increased expression of TLR4 protein
Methadone affects the susceptibility to TLR4 protein
Naloxone affects the reaction [Methadone binds to TLR4 protein]
CTD PMID:20178837 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression
EXP Methadone results in increased secretion of TNF protein
Methadone results in increased expression of TNF protein
CTD PMID:20178837 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
morphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects metabolic processing
multiple interactions
ISO
EXP
ABCB1 affects the metabolism of Morphine
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA
CTD PMID:23748253 PMID:26554626 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA CTD PMID:26554626 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 decreases expression ISO Morphine results in decreased expression of ABTB3 mRNA CTD PMID:21955143 NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression
multiple interactions
EXP Morphine results in decreased expression of ACAT1 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of ACAT1 protein]
CTD PMID:23056601 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases chemical synthesis
ISO [ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
ACHE protein results in increased chemical synthesis of Morphine
CTD PMID:30080993 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adcy1 adenylate cyclase 1 multiple interactions ISO [ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine CTD PMID:16914643 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
JBrowse link
G Adcy6 adenylate cyclase 6 affects expression EXP Morphine affects the expression of ADCY6 mRNA CTD PMID:15829634 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Adcy8 adenylate cyclase 8 affects response to substance
affects expression
multiple interactions
ISO
EXP
ADCY8 protein affects the susceptibility to Morphine
Morphine affects the expression of ADCY8 mRNA
[ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine
CTD PMID:15829634 PMID:16914643 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911
JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 decreases expression ISO Morphine results in decreased expression of ADGRA1 mRNA CTD PMID:21955143 NCBI chr 1:194,629,744...194,673,254
Ensembl chr 1:194,629,726...194,672,550
JBrowse link
G Adora1 adenosine A1 receptor affects response to substance
increases expression
multiple interactions
ISO
EXP
ADORA1 protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA1 mRNA; Morphine results in increased expression of ADORA1 protein
[lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA; [lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein
CTD PMID:9407998 PMID:26478469 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance
increases expression
ISO ADORA2A protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA2A mRNA
CTD PMID:14756803 PMID:21955143 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression EXP morphine increases expression of Adra2a mRNA in cerebral cortex RGD PMID:9105684 RGD:401976538 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Agrp agouti related neuropeptide increases expression ISO Morphine results in increased expression of AGRP mRNA CTD PMID:20144693 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression
EXP
ISO
[lead acetate co-treated with Morphine] results in increased expression of AIF1 mRNA
corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of AIF1 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]
CTD PMID:26478469 PMID:37394652 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Ak5 adenylate kinase 5 decreases expression ISO Morphine results in decreased expression of AK5 mRNA CTD PMID:21955143 NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 decreases expression EXP Morphine results in decreased expression of AKR1B1 protein CTD PMID:23056601 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression
decreases expression
ISO ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]
Morphine results in increased expression of AKT1 protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form]
CTD PMID:19239323 PMID:20600172 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of ALB protein] CTD PMID:23056601 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Ano3 anoctamin 3 increases expression ISO Morphine results in increased expression of ANO3 mRNA CTD PMID:21955143 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154
JBrowse link
G Anxa6 annexin A6 decreases expression EXP Morphine results in decreased expression of ANXA6 protein CTD PMID:23056601 NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433
JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP Morphine results in increased expression of APOA1 protein CTD PMID:23056601 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apob apolipoprotein B increases expression ISO Morphine results in increased expression of APOB protein CTD PMID:18980684 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoe apolipoprotein E increases expression
multiple interactions
EXP Morphine results in increased expression of APOE protein
Morphine deficiency affects the reaction [Morphine results in increased expression of APOE protein]
CTD PMID:23056601 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Morphine results in increased expression of AQP1 mRNA CTD PMID:21178816 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression EXP Morphine results in increased expression of AQP3 mRNA; Morphine results in increased expression of AQP3 protein CTD PMID:25766885 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO Morphine results in decreased expression of AQP4 mRNA CTD PMID:21955143 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP
IEP
morphine increases expression in Arc protein in nucleus accumbens
morphine increases expression of Arc mRNA in prefrontal cortex
morphine co-treated with naloxone increases expression of Arc protein in brain
Morphine increases expression of Arc protein in shell of nucleus accumbens
RGD PMID:21549764 PMID:30550948 PMID:19262551 PMID:25746394 RGD:401851922, RGD:401959617, RGD:401938601, RGD:11087075 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Arl4d ARF like GTPase 4D increases expression ISO Morphine results in increased expression of ARL4D mRNA CTD PMID:20144693 NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836
JBrowse link
G Arl6ip5 ARF like GTPase 6 interacting protein 5 multiple interactions
increases expression
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine results in increased expression of ARL6IP5 protein
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
CTD PMID:21600884 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 increases expression
decreases expression
ISO Morphine results in increased expression of ARPP21 mRNA
Morphine deficiency results in decreased expression of ARPP21 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297
JBrowse link
G Arrb2 arrestin, beta 2 affects response to substance
multiple interactions
ISO
EXP
ARRB2 gene SNP affects the susceptibility to Morphine
[Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein
ARRB2 protein affects the susceptibility to Morphine
[gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
CTD PMID:16103897 PMID:19239323 PMID:19477204 PMID:23300227 PMID:24063433 More... NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Art3 ADP-ribosyltransferase 3 multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein] CTD PMID:23056601 NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407
JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 increases expression ISO Morphine results in increased expression of ASIC4 mRNA CTD PMID:21178816 NCBI chr 9:76,941,532...76,962,900
Ensembl chr 9:76,941,532...76,962,900
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]] CTD PMID:37394652 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase decreases expression EXP Morphine results in decreased expression of ATIC protein CTD PMID:23056601 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO Morphine results in increased expression of ATRX mRNA CTD PMID:21955143 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330
JBrowse link
G Avp arginine vasopressin increases expression ISO Morphine increases expression of Avp mRNA in the dorsal striatum RGD PMID:29772497 RGD:408418735 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression ISO Morphine results in decreased expression of AVPR1A mRNA CTD PMID:21178816 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Bag3 BAG cochaperone 3 increases expression EXP Morphine results in increased expression of BAG3 protein CTD PMID:23056601 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Morphine results in increased expression of BAK1 protein CTD PMID:19070643 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Morphine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
Morphine results in increased expression of BAX mRNA; Morphine results in increased expression of BAX protein
Morphine results in decreased expression of BAX mRNA
epigallocatechin gallate inhibits the reaction [Morphine results in increased expression of BAX protein]; Lithium inhibits the reaction [Morphine results in increased expression of BAX mRNA]
TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein]
CTD PMID:10534122 PMID:10809959 PMID:12196588 PMID:12702572 PMID:12927789 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Morphine results in increased expression of BBC3 mRNA CTD PMID:19397953 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcas1 brain enriched myelin associated protein 1 decreases expression ISO Morphine results in decreased expression of BCAS1 mRNA CTD PMID:21955143 NCBI chr 3:159,136,077...159,219,072
Ensembl chr 3:159,136,083...159,219,106
JBrowse link
G Bche butyrylcholinesterase increases chemical synthesis
multiple interactions
ISO BCHE protein results in increased chemical synthesis of Morphine
[BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
CTD PMID:30080993 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl11b BCL11 transcription factor B increases expression
decreases expression
ISO Morphine results in increased expression of BCL11B mRNA
Morphine deficiency results in decreased expression of BCL11B mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]; PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]
Morphine results in decreased expression of BCL2 mRNA; Morphine results in decreased expression of BCL2 protein
epigallocatechin gallate inhibits the reaction [Morphine results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA]
CTD PMID:10534122 PMID:12196588 PMID:12927789 PMID:17542780 PMID:18976035 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Morphine results in decreased expression of BCL2L1 mRNA CTD PMID:15183518 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO Morphine results in increased expression of BCL2L11 protein CTD PMID:19292871 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
increases expression
decreases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of BDNF mRNA; Morphine results in increased expression of BDNF protein
Morphine increases expression of Bdnf mRNA in ventral tegmental area
Morphine results in decreased expression of BDNF mRNA; Morphine results in decreased expression of BDNF mRNA alternative form
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]; Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]; Morphine promotes the reaction [ING2 protein binds to BDNF promoter]; Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]; Morphine promotes the reaction [SIN3A protein binds to BDNF promoter]; Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter]
AM 251 inhibits the reaction [Morphine results in increased expression of BDNF protein]; BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]
CTD
RGD
PMID:19033880 PMID:25643298 PMID:27461790 PMID:30550948 RGD:401959617 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]
Morphine results in increased expression of BECN1 protein
CTD PMID:20190558 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bex4 brain expressed, X-linked 4 increases expression ISO Morphine results in increased expression of BEX4 mRNA CTD PMID:21178816 NCBI chr  X:99,131,985...99,133,417
Ensembl chr  X:99,131,942...99,133,531
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Morphine results in decreased expression of BOK mRNA CTD PMID:21955143 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G C1ql3 complement C1q like 3 increases expression ISO Morphine results in increased expression of C1QL3 mRNA CTD PMID:21178816 NCBI chr17:76,119,344...76,129,170
Ensembl chr17:76,119,447...76,128,530
JBrowse link
G Calb1 calbindin 1 increases expression ISO Morphine results in increased expression of CALB1 mRNA CTD PMID:21178816 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression
multiple interactions
EXP
ISO
Morphine results in increased expression of CALCA mRNA; Morphine results in increased expression of CALCA protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]
GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]
CTD PMID:16935424 PMID:20359526 PMID:20568289 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha affects response to substance
increases expression
ISO CAMK2A protein affects the susceptibility to Morphine
Morphine results in increased expression of CAMK2A mRNA
CTD PMID:20053885 PMID:21955143 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 decreases expression ISO Morphine results in decreased expression of CAP1 mRNA CTD PMID:21955143 NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769
JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO Morphine results in increased expression of CAR2 mRNA CTD PMID:20144693 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 increases expression ISO Morphine results in increased expression of CARHSP1 mRNA CTD PMID:21178816 NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019
JBrowse link
G Cartpt CART prepropeptide increases expression ISO Morphine results in increased expression of CARTPT mRNA CTD PMID:20144693 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp1 caspase 1 decreases expression EXP Morphine results in decreased expression of CASP1 mRNA CTD PMID:15183518 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Morphine results in increased activity of and results in increased cleavage of CASP3 protein; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]
Morphine results in increased cleavage of CASP3 protein
Morphine results in increased expression of CASP3 protein
epigallocatechin gallate inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]
corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form]; SB 203580 inhibits the reaction [Morphine results in increased activity of CASP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]
Morphine results in increased expression of CASP3 protein; Morphine results in increased expression of CASP3 protein alternative form
CTD PMID:10534122 PMID:11590188 PMID:12196588 PMID:16102899 PMID:17542780 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
decreases expression
ISO ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
Morphine results in increased activity of CASP8 protein
CTD PMID:11590188 PMID:19070643 PMID:19239323 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
ISO
EXP
Morphine results in increased activity of CASP9 protein
Morphine results in increased expression of CASP9 mRNA
CTD PMID:15183518 PMID:19292871 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Morphine results in increased abundance of Hydrogen Peroxide] CTD PMID:14871405 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbln1 cerebellin 1 precursor decreases expression ISO Morphine results in decreased expression of CBLN1 mRNA CTD PMID:21955143 NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572
JBrowse link
G Ccdc136 coiled-coil domain containing 136 decreases expression ISO Morphine results in decreased expression of CCDC136 mRNA CTD PMID:21955143 NCBI chr 4:57,997,825...58,027,598
Ensembl chr 4:57,997,853...58,027,646
JBrowse link
G Cck cholecystokinin decreases expression ISO Morphine results in decreased expression of CCK mRNA CTD PMID:21955143 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Morphine CTD PMID:11403953 PMID:11880531 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP Morphine results in increased secretion of CCL2 protein CTD PMID:20178837 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion EXP Morphine results in increased secretion of CCL3 protein CTD PMID:20178837 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
ISO beta-funaltrexamine inhibits the reaction [Morphine results in decreased expression of CCL5 protein]; Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd38 CD38 molecule affects response to substance ISO CD38 affects the susceptibility to Morphine CTD PMID:20551293 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Cd79b CD79b molecule increases expression ISO Morphine results in increased expression of CD79B mRNA CTD PMID:20144693 NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625
JBrowse link
G Cd9 CD9 molecule increases expression EXP Morphine results in increased expression of CD9 protein CTD PMID:23056601 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
JBrowse link
G Cdh22 cadherin 22 increases expression ISO Morphine results in increased expression of CDH22 mRNA CTD PMID:21178816 NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein CTD PMID:12702572 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cep83 centrosomal protein 83 increases expression ISO Morphine results in increased expression of CEP83 mRNA CTD PMID:20144693 NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:29,280,419...29,389,574
JBrowse link
G Ces2h carboxylesterase 2H increases chemical synthesis
multiple interactions
ISO CES2 protein results in increased chemical synthesis of Morphine
Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine]
CTD PMID:8930175 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 affects response to substance ISO CHRM5 protein affects the susceptibility to Morphine CTD PMID:12154229 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Morphine results in increased expression of CIRBP mRNA CTD PMID:21955143 NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
JBrowse link
G Cldn2 claudin 2 increases expression ISO Morphine results in increased expression of CLDN2 mRNA CTD PMID:21178816 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Morphine results in decreased expression of CMBL protein CTD PMID:23056601 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 increases expression ISO Morphine results in increased expression of CMTM5 mRNA CTD PMID:21955143 NCBI chr15:28,412,624...28,415,304
Ensembl chr15:28,412,624...28,415,287
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of CNBP protein] CTD PMID:23056601 NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases expression
increases expression
EXP
ISO
[Morphine results in increased expression of CNR1 mRNA] which results in increased susceptibility to Dronabinol; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
Morphine deficiency results in decreased expression of CNR1 mRNA
CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
CTD PMID:9351646 PMID:21955143 PMID:22258905 PMID:27126842 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Comt catechol-O-methyltransferase affects response to substance
multiple interactions
ISO COMT protein affects the susceptibility to Morphine
[COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine
CTD PMID:18834357 PMID:21127283 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Coq9 coenzyme Q9 decreases expression EXP Morphine results in decreased expression of COQ9 protein CTD PMID:23056601 NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949
JBrowse link
G Cpe carboxypeptidase E increases expression ISO Morphine results in increased expression of CPE mRNA CTD PMID:20144693 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
decreases phosphorylation
increases phosphorylation
multiple interactions
increases expression
EXP
ISO
Morphine results in decreased expression of CREB1 mRNA
morphine decreases phosphorylation of Creb1 protein in prefrontal cortex
morphine increases phosphorylation of Creb protein in Cortical cell
AM 251 inhibits the reaction [Morphine results in increased phosphorylation of CREB1 protein]; suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein]
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter]
Morphine results in decreased phosphorylation of CREB1 protein
CTD
RGD
PMID:14750654 PMID:15183518 PMID:16598705 PMID:23292329 PMID:25643298 More... RGD:401901600, RGD:401901284 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Morphine results in increased expression of CREM mRNA CTD PMID:22454534 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Crh corticotropin releasing hormone increases expression ISO Morphine deficiency results in increased expression of CRH mRNA; Morphine results in increased expression of CRH mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Morphine deficiency
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25582704 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Crp C-reactive protein increases expression ISO Morphine results in increased expression of CRP protein CTD PMID:18980684 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cryab crystallin, alpha B decreases expression
increases expression
ISO
EXP
Morphine results in decreased expression of CRYAB mRNA
Morphine results in increased expression of CRYAB protein
CTD PMID:21955143 PMID:23056601 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Csdc2 cold shock domain containing C2 decreases expression ISO Morphine results in decreased expression of CSDC2 mRNA CTD PMID:21955143 NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:113,451,998...113,466,463
JBrowse link
G Cstb cystatin B decreases expression EXP Morphine results in decreased expression of CSTB protein CTD PMID:23056601 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
JBrowse link
G Ctnnal1 catenin alpha-like 1 increases expression ISO Morphine results in increased expression of CTNNAL1 mRNA CTD PMID:21178816 NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431
JBrowse link
G Ctsb cathepsin B increases expression EXP Morphine results in increased expression of CTSB mRNA CTD PMID:9429908 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Cux2 cut-like homeobox 2 increases expression ISO Morphine results in increased expression of CUX2 mRNA CTD PMID:21178816 NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects response to substance
increases secretion
EXP CX3CL1 protein affects the susceptibility to Morphine
Morphine results in increased secretion of CX3CL1 protein
CTD PMID:15317861 PMID:20178837 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion EXP Morphine results in increased secretion of CXCL1 protein CTD PMID:20178837 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxxc1 CXXC finger protein 1 affects expression ISO Morphine affects the expression of CXXC1 mRNA CTD PMID:33891991 NCBI chr18:67,813,185...67,818,556
Ensembl chr18:67,813,206...67,818,551
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression
multiple interactions
ISO Morphine results in increased expression of CYBB protein
Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein]
CTD PMID:14871405 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic increases secretion
decreases secretion
multiple interactions
ISO
EXP
Morphine results in increased secretion of CYCS protein
Morphine results in decreased secretion of CYCS protein
Morphine inhibits the reaction [Doxorubicin affects the localization of CYCS protein]
CTD PMID:15345483 PMID:17542780 PMID:19292871 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Morphine results in decreased activity of CYP1A2 protein CTD PMID:35914676 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Morphine results in increased expression of CYP27A1 mRNA CTD PMID:20144693 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity ISO Morphine results in increased activity of CYP2B6 protein CTD PMID:35914676 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects chemical synthesis
increases activity
multiple interactions
ISO CYP2D6 protein affects the chemical synthesis of Morphine
Morphine results in increased activity of CYP2D6 protein
[CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
CTD PMID:15625333 PMID:16595712 PMID:21241245 PMID:35914676 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Dbi diazepam binding inhibitor increases expression EXP morphine increases expression of Dbi mRNA in brain RGD PMID:15950760 RGD:408361840 NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of DCXR protein] CTD PMID:23056601 NCBI chr10:106,006,404...106,008,293 JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein] CTD PMID:23056601 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression
multiple interactions
ISO Morphine results in increased expression of DDB2 mRNA
Naloxone inhibits the reaction [Morphine results in increased expression of DDB2]
CTD PMID:19397953 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]] CTD PMID:37394652 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Morphine results in decreased expression of DHCR24 mRNA CTD PMID:21955143 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B increases expression ISO Morphine results in increased expression of DHRS7B mRNA CTD PMID:21178816 NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
increases expression
EXP
ISO
Morphine results in decreased expression of DLG4 mRNA; Morphine results in decreased expression of DLG4 protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]
Morphine results in increased expression of DLG4 mRNA
CTD PMID:15183518 PMID:16598705 PMID:21955143 PMID:22713680 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dlx5 distal-less homeobox 5 increases expression ISO Morphine results in increased expression of DLX5 mRNA CTD PMID:21178816 NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:34,999,139...35,003,407
JBrowse link
G Dnah3 dynein, axonemal, heavy chain 3 decreases expression ISO Morphine results in decreased expression of DNAH3 mRNA CTD PMID:21178816 NCBI chr 1:174,305,929...174,479,490
Ensembl chr 1:174,306,644...174,479,474
JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO Morphine results in increased expression of DNMT1 mRNA CTD PMID:33891991 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha affects expression ISO Morphine affects the expression of DNMT3A mRNA CTD PMID:33891991 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta affects expression ISO Morphine affects the expression of DNMT3B mRNA CTD PMID:33891991 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO Morphine results in increased expression of DOCK10 mRNA CTD PMID:21178816 NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of DPYSL2 protein] CTD PMID:23056601 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 multiple interactions
decreases expression
EXP Morphine deficiency promotes the reaction [Morphine results in decreased expression of DPYSL3 protein] CTD PMID:23056601 NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
JBrowse link
G Drd1 dopamine receptor D1 increases expression
decreases expression
ISO Morphine results in increased expression of DRD1 mRNA
Morphine deficiency results in decreased expression of DRD1 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 decreases expression
multiple interactions
affects response to substance
increases expression
EXP
ISO
Morphine results in decreased expression of DRD2 mRNA
Morphine deficiency results in decreased expression of DRD2 mRNA
[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA; [lead acetate co-treated with Morphine] results in increased expression of DRD2 protein
DRD2 protein affects the susceptibility to Morphine
Morphine results in increased expression of DRD2 mRNA
CTD PMID:2571179 PMID:15183518 PMID:17063042 PMID:23702354 PMID:27126842 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd4 dopamine receptor D4 increases expression EXP Morphine results in increased expression of DRD4 mRNA CTD PMID:15183518 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases expression ISO Morphine results in increased expression of DSCAML1 mRNA CTD PMID:20144693 NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Morphine deficiency results in increased expression of DUSP6 mRNA; Morphine results in increased expression of DUSP6 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO Morphine results in decreased expression of DYNC1H1 mRNA CTD PMID:21178816 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Morphine results in decreased expression of ECH1 protein CTD PMID:23056601 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Eed embryonic ectoderm development increases expression ISO Morphine results in increased expression of EED mRNA CTD PMID:33891991 NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974
JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO Morphine results in decreased expression of EFHD1 mRNA CTD PMID:21955143 NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917
JBrowse link
G Egr1 early growth response 1 increases expression
increases expression
ISO
EXP
Morphine deficiency results in increased expression of EGR1 mRNA; Morphine results in increased expression of EGR1 mRNA
Morphine increases expression of Egr1 mRNA in ventral tegmental area and prefrontal cortex
CTD
RGD
PMID:21955143 PMID:27126842 PMID:30550948 RGD:401959617 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 increases expression ISO Morphine results in increased expression of EGR2 mRNA CTD PMID:22454534 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Egr3 early growth response 3 increases expression ISO Morphine results in increased expression of EGR3 mRNA CTD PMID:21955143 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Egr4 early growth response 4 multiple interactions
increases expression
affects response to substance
ISO
EXP
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA]; [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
EGR4 protein affects the susceptibility to Morphine
CTD PMID:22454534 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
JBrowse link
G Ehd1 EH-domain containing 1 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of EHD1 protein] CTD PMID:23056601 NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212
JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 affects expression ISO Morphine affects the expression of EHMT1 mRNA CTD PMID:33891991 NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 affects expression ISO Morphine affects the expression of EHMT2 mRNA CTD PMID:33891991 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]] CTD PMID:37394652 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A increases expression ISO Morphine results in increased expression of EIF5A mRNA CTD PMID:19397953 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
JBrowse link
G Elk1 ETS transcription factor ELK1 affects response to substance
increases activity
multiple interactions
ISO ELK1 protein affects the susceptibility to Morphine
Morphine results in increased activity of ELK1 protein
[Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
CTD PMID:22454534 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Eml2 EMAP like 2 increases expression EXP Morphine results in increased expression of EML2 protein CTD PMID:23056601 NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression EXP Morphine results in increased expression of ENPP3 protein CTD PMID:23056601 NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041
JBrowse link
G Ephx2 epoxide hydrolase 2 increases expression ISO Morphine results in increased expression of EPHX2 mRNA CTD PMID:21178816 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO Morphine results in increased expression of ERP44 mRNA CTD PMID:21178816 NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions
affects expression
EXP
ISO
Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]
Morphine affects the expression of EZH2 mRNA
CTD PMID:25643298 PMID:33891991 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G F2 coagulation factor II, thrombin increases expression
multiple interactions
EXP Morphine results in increased expression of F2 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of F2 protein]
CTD PMID:23056601 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F7 coagulation factor VII increases expression ISO Morphine results in increased expression of F7 protein CTD PMID:18980684 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fam107a family with sequence similarity 107, member A increases expression ISO Morphine results in increased expression of FAM107A mRNA CTD PMID:21955143 NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein
Morphine results in increased expression of FAS mRNA
CTD PMID:12702572 PMID:16210602 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of FASL mRNA
CTD PMID:16210602 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fblim1 filamin binding LIM protein 1 increases expression
multiple interactions
EXP Morphine results in increased expression of FBLIM1 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of FBLIM1 protein]
CTD PMID:23056601 NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO Morphine results in decreased expression of FBN1 mRNA CTD PMID:21178816 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fga fibrinogen alpha chain affects secretion EXP Morphine affects the secretion of FGA protein modified form CTD PMID:24855564 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases secretion
multiple interactions
ISO Morphine results in decreased secretion of FGF2 protein
Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
CTD PMID:20564181 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression EXP Morphine results in increased expression of FGFR1 mRNA CTD PMID:15183518 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fh fumarate hydratase increases expression EXP Morphine results in increased expression of FH protein CTD PMID:23056601 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
JBrowse link
G Fhl2 four and a half LIM domains 2 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein] CTD PMID:23056601 NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Morphine results in increased expression of FN1 mRNA CTD PMID:20144693 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects expression
increases expression
ISO
EXP
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein; [Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Plant Extracts inhibits the reaction [Morphine results in increased expression of FOS protein]
Morphine deficiency affects the expression of FOS protein
Morphine results in increased expression of FOS mRNA; Morphine results in increased expression of FOS protein
Morphine affects the expression of FOS mRNA
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Morphine results in increased expression of FOS protein]; [Morphine co-treated with Cocaine] affects the expression of FOS; [Morphine co-treated with N-Methyl-3,4-methylenedioxyamphetamine] affects the expression of FOS; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; Genistein inhibits the reaction [Morphine results in increased expression of FOS protein]; Morphine affects the reaction [Formaldehyde results in increased expression of FOS protein]; N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide inhibits the reaction [Morphine results in increased expression of FOS protein]; Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]; SCH772984 inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; U 0126 inhibits the reaction [Morphine results in increased expression of FOS protein]
CTD PMID:10521585 PMID:10814832 PMID:12821175 PMID:12934646 PMID:15183518 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein]
morphine increases expression of Fosb protein in nucleus accumbens and caudate-putamen
morphine increases expression of FosB mRNA in striatum
morphine increases expression of Fosb protein in the Brainstem
morphine increases expression of Fosb protein in brain
Morphine results in increased expression of FOSB mRNA
Morphine results in increased expression of FOSB mRNA; Morphine results in increased expression of FOSB protein; Morphine results in increased expression of FOSB protein alternative form; Morphine results in increased expression of FOSB protein modified form
CTD
RGD
PMID:15899480 PMID:18293355 PMID:22454534 PMID:23185589 PMID:19324071 More... RGD:401901600, RGD:401901284, RGD:401851072, RGD:401900159, RGD:401851068 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Foxp1 forkhead box P1 increases expression
decreases expression
ISO Morphine results in increased expression of FOXP1 mRNA
Morphine deficiency results in decreased expression of FOXP1 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 decreases expression ISO Morphine results in decreased expression of FXYD7 mRNA CTD PMID:21955143 NCBI chr 1:86,277,678...86,286,954
Ensembl chr 1:86,277,678...86,286,954
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression
increases expression
EXP Morphine results in decreased expression of GABRA1 mRNA
Morphine results in increased expression of GABRA1 mRNA
CTD PMID:15183518 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Morphine results in increased expression of GABRA4 mRNA CTD PMID:21178816 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP Morphine results in increased expression of GABRD mRNA CTD PMID:15183518 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Morphine results in increased expression of GABRG2 mRNA CTD PMID:21955143 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Morphine results in increased expression of GAD1 mRNA CTD PMID:15673448 PMID:18312583 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO Morphine results in increased expression of GAD2 mRNA CTD PMID:21178816 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression
decreases expression
ISO Morphine results in increased expression of GAL mRNA
Morphine results in decreased expression of GAL mRNA
CTD PMID:21178816 PMID:21955143 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Galr1 galanin receptor 1 increases expression ISO morphine co-treated with naltrexone increases expression of Galr1 in locus ceruleus RGD PMID:10882839 RGD:407984714 NCBI chr18:75,772,021...75,787,577
Ensembl chr18:75,772,023...75,787,577
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP Morphine results in decreased expression of GAPDH protein CTD PMID:23056601 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression
decreases expression
ISO Morphine results in increased expression of GCNT2 mRNA
Morphine deficiency results in decreased expression of GCNT2 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
ISO
EXP
Morphine results in decreased expression of GFAP mRNA
[lead acetate co-treated with Morphine] results in increased expression of GFAP mRNA
CTD PMID:21955143 PMID:26478469 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 decreases expression EXP Morphine results in decreased expression of GFM1 protein CTD PMID:23056601 NCBI chr 2:151,700,573...151,745,477
Ensembl chr 2:151,700,564...151,745,471
JBrowse link
G Gh1 growth hormone 1 decreases expression
increases secretion
ISO
EXP
Morphine results in decreased expression of GH mRNA
Morphine results in increased secretion of GH1 protein
CTD PMID:7201058 PMID:21178816 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Gjc2 gap junction protein, gamma 2 decreases expression ISO Morphine results in decreased expression of GJC2 mRNA CTD PMID:21955143 NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467
JBrowse link
G Glra2 glycine receptor, alpha 2 increases expression ISO Morphine results in increased expression of GLRA2 mRNA CTD PMID:21178816 NCBI chr  X:29,020,377...29,241,666
Ensembl chr  X:29,020,557...29,241,666
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression
multiple interactions
increases expression
EXP
ISO
Morphine results in decreased expression of GNAI2 mRNA
Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]
Morphine results in increased expression of GNAI2 mRNA
CTD PMID:15183518 PMID:18652891 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnas GNAS complex locus increases expression EXP Morphine results in increased expression of GNAS mRNA; Morphine results in increased expression of GNAS protein CTD PMID:17893922 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnaz G protein subunit alpha z multiple interactions ISO Morphine promotes the reaction [GNAZ protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907
JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Morphine results in decreased expression of GNG11 mRNA CTD PMID:21955143 NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442
JBrowse link
G Gng2 G protein subunit gamma 2 increases expression EXP Morphine results in increased expression of GNG2 mRNA CTD PMID:15183518 NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183
JBrowse link
G Gpr6 G protein-coupled receptor 6 decreases expression ISO Morphine results in decreased expression of GPR6 mRNA CTD PMID:21955143 NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624
JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression
decreases expression
ISO Morphine results in increased expression of GPR88 mRNA
Morphine deficiency results in decreased expression of GPR88 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 2:204,191,443...204,199,576
Ensembl chr 2:204,191,427...204,199,733
JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B decreases expression ISO Morphine results in decreased expression of GPRC5B mRNA CTD PMID:21955143 NCBI chr 1:173,316,904...173,340,933
Ensembl chr 1:173,316,907...173,340,932
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 affects response to substance
increases localization
increases expression
decreases phosphorylation
affects expression
increases phosphorylation
multiple interactions
decreases expression
ISO
EXP
GRIA1 protein affects the susceptibility to Morphine
Morphine increases localization of Gria1 protein on shell of nucleus accumbens cell surface
Morphine increases expression of Gria protein in the nucleus accumbens
Morphine increases localization of Gria1 protein on nucleus accumbens cell surface
Morphine decreases phosphorylation of Gria1 protein in the caudate-putamen, nucleus accumbens
Morphine alters expression of Gria1 protein in prefrontal cortex membrane
Morphine withdrawal increases phosphorylation of Gria1 protein in hippocampal formation postsynaptic density
Morphine increases expression of Gria1 protein in the striatum
Morphine increases expression of Gria1 protein in the central amygdaloid nucleus
Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]
Morphine results in increased expression of GRIA1 mRNA
Morphine results in decreased expression of GRIA1 mRNA; Morphine results in decreased expression of GRIA1 protein
Morphine results in decreased phosphorylation of GRIA1 protein
CTD
RGD
PMID:11404432 PMID:15183518 PMID:15287884 PMID:23711322 PMID:25643298 More... RGD:11087075, RGD:405818276, RGD:405650668, RGD:405650198, RGD:405649863, RGD:405101691, RGD:405100728, RGD:405100238 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP Morphine results in decreased expression of GRIA2 protein CTD PMID:23711322 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP Morphine results in decreased expression of GRIA3 mRNA CTD PMID:15183518 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096
JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression EXP Morphine results in decreased expression of GRIA4 mRNA CTD PMID:15183518 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions
affects response to substance
ISO GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]
GRIK1 protein affects the susceptibility to Morphine
CTD PMID:20359526 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
increases expression
increases phosphorylation
decreases phosphorylation
affects phosphorylation
ISO
EXP
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]
morphine increases expression of Nr1 protein in cortical neurons
morphine increases phosphorylation of Nr1 protein in frontal cortex and cortical neurons
Morphine results in increased expression of GRIN1 protein
Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]; Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein]
Morphine results in decreased phosphorylation of GRIN1 protein
Morphine affects the phosphorylation of GRIN1 protein
CTD
RGD
PMID:15287884 PMID:17996026 PMID:20519536 PMID:20950603 PMID:22713680 More... RGD:401901284, RGD:401901284 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression
affects response to substance
ISO Morphine results in increased expression of GRIN2A protein
GRIN2A protein affects the susceptibility to Morphine
CTD PMID:12878694 PMID:33609567 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases expression
increases phosphorylation
ISO
EXP
MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]
Morphine results in increased expression of GRIN2B protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN2B protein]
CTD PMID:20519536 PMID:22713680 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C increases expression EXP Morphine results in increased expression of GRIN2C mRNA CTD PMID:15183518 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 increases expression EXP Morphine results in increased expression of GRK5 mRNA CTD PMID:15183518 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
JBrowse link
G Grm1 glutamate metabotropic receptor 1 increases expression EXP Morphine results in increased expression of GRM1 mRNA CTD PMID:15183518 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Grm5 glutamate metabotropic receptor 5 increases expression
decreases expression
ISO Morphine results in increased expression of GRM5 mRNA
Morphine deficiency results in decreased expression of GRM5 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions
ISO Morphine results in increased expression of GSK3B protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form]
CTD PMID:20600172 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hcrtr1 hypocretin receptor 1 increases expression EXP Morphine results in increased expression of HCRTR1 mRNA; Morphine results in increased expression of HCRTR1 protein CTD PMID:32319158 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674
JBrowse link
G Hdac5 histone deacetylase 5 increases expression EXP Morphine results in increased expression of HDAC5 protein CTD PMID:35461814 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions
increases response to substance
ISO HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
HINT1 gene mutant form results in increased susceptibility to Morphine
CTD PMID:18652891 PMID:21235400 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO Morphine results in decreased expression of HMGCS1 mRNA CTD PMID:21955143 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO Morphine results in increased expression of HMGCS2 mRNA CTD PMID:20144693 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Morphine results in increased expression of HMOX1 protein CTD PMID:14871405 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 decreases activity
increases activity
EXP Morphine results in decreased activity of HMOX2 protein
Morphine results in increased activity of HMOX2 protein
CTD PMID:12812915 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like increases expression ISO Morphine results in increased expression of HNRNPDL mRNA CTD PMID:20144693 NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506
JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L increases expression ISO Morphine deficiency results in increased expression of HNRNPL mRNA; Morphine results in increased expression of HNRNPL mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553
JBrowse link
G Homer1 homer scaffold protein 1 increases expression ISO Morphine results in increased expression of HOMER1 mRNA CTD PMID:21955143 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hp haptoglobin decreases expression EXP Morphine results in decreased expression of HP protein CTD PMID:23056601 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Hpca hippocalcin increases expression
decreases expression
ISO Morphine results in increased expression of HPCA mRNA
Morphine deficiency results in decreased expression of HPCA mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases response to substance
ISO Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine] CTD PMID:12128009 PMID:14569158 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases response to substance
ISO [zolantidine binds to and results in decreased activity of HRH2 protein] which results in increased susceptibility to Morphine; Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]
HRH2 protein results in decreased susceptibility to Morphine; HRH2 results in decreased susceptibility to Morphine
CTD PMID:14569158 PMID:16806305 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 increases expression ISO Morphine results in increased expression of HS6ST2 mRNA CTD PMID:21178816 NCBI chr  X:130,966,547...131,261,629
Ensembl chr  X:130,968,385...131,261,492
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Morphine results in decreased expression of HSD11B1 mRNA CTD PMID:21955143 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP Morphine results in increased expression of HSP90AB1 mRNA CTD PMID:15497504 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression EXP Morphine results in decreased expression of HSP90B1 protein CTD PMID:23056601 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
EXP Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA]
Morphine results in increased expression of HSPA1A mRNA; Morphine results in increased expression of HSPA1A protein
CTD PMID:15497504 PMID:23056601 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Morphine results in increased expression of HSPA5 protein
corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]]
CTD PMID:37394652 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Morphine results in increased expression of HSPA8 mRNA CTD PMID:15497504 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Morphine results in increased expression of HSPB1 mRNA; Morphine results in increased expression of HSPB1 protein CTD PMID:15497504 PMID:23056601 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP Morphine results in increased expression of HSPE1 protein CTD PMID:23056601 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
decreases expression
EXP 4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine
Morphine decreases expression of Htr1a mRNA in the dorsal raphe nucleus
CTD
RGD
PMID:10640309 PMID:24055683 RGD:405866344 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases expression ISO Morphine results in increased expression of HTR3A mRNA CTD PMID:21178816 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP Morphine results in decreased expression of ICAM1 protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]
CTD PMID:10070497 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression
multiple interactions
EXP Morphine results in decreased expression of IDH3B protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of IDH3B protein]
CTD PMID:23056601 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO Morphine results in decreased expression of IFNG
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]
CTD PMID:11590188 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO Morphine results in decreased expression of IGSF1 mRNA CTD PMID:21955143 NCBI chr  X:129,069,891...129,085,331
Ensembl chr  X:129,069,896...129,085,139
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Morphine affects the expression of [IL12A protein binds to IL12B protein] CTD PMID:16299287 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions
affects expression
ISO Morphine affects the expression of [IL12A protein binds to IL12B protein]
Morphine affects the expression of IL12B protein
CTD PMID:16299287 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13 interleukin 13 increases expression ISO Morphine results in increased expression of IL13 protein CTD PMID:16210602 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression
ISO Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]; Dexamethasone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Dexamethasone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]; Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]; Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] CTD PMID:12182845 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
EXP
ISO
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL1B mRNA]
corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]
Morphine results in increased expression of IL1B mRNA; Morphine results in increased expression of IL1B protein
Morphine results in increased secretion of IL1B protein
CTD PMID:12427855 PMID:20178837 PMID:21081778 PMID:22713680 PMID:24756886 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist affects response to substance ISO IL1RN protein affects the susceptibility to Morphine CTD PMID:15317861 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
ISO Morphine results in decreased expression of IL2
Morphine results in decreased expression of IL2 mRNA
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]
CTD PMID:11590188 PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of IL4 mRNA; Morphine results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Morphine results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Morphine results in increased expression of IL4 mRNA]
CTD PMID:16210602 PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression
ISO
EXP
Morphine results in increased secretion of IL6 protein
corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]
Morphine results in increased expression of IL6 mRNA; Morphine results in increased expression of IL6 protein
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL6 mRNA]
CTD PMID:12427855 PMID:15317861 PMID:20564181 PMID:21081778 PMID:22713680 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ing2 inhibitor of growth family, member 2 multiple interactions EXP Morphine promotes the reaction [ING2 protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Morphine results in increased expression of ITGAM mRNA CTD PMID:37981055 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; Morphine results in increased phosphorylation of and results in increased activity of JUN protein; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein] CTD PMID:19292871 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Morphine results in increased expression of JUNB mRNA CTD PMID:21955143 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Klf7 KLF transcription factor 7 increases expression
multiple interactions
ISO Morphine results in increased expression of KLF7 mRNA; Morphine results in increased expression of KLF7 protein
Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA]
CTD PMID:14644156 NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261
JBrowse link
G Klrk1 killer cell lectin like receptor K1 decreases expression ISO Morphine results in decreased expression of KLRK1 mRNA CTD PMID:20144693 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459
JBrowse link
G Kmt2a lysine methyltransferase 2A multiple interactions
affects expression
EXP
ISO
Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]
Morphine affects the expression of KMT2A mRNA
CTD PMID:25643298 PMID:33891991 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Krt1 keratin 1 decreases expression EXP Morphine results in decreased expression of KRT1 protein CTD PMID:23056601 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Krt10 keratin 10 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of KRT10 protein] CTD PMID:23056601 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
JBrowse link
G Krt2 keratin 2 decreases expression
multiple interactions
EXP Morphine results in decreased expression of KRT2 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT2 protein]
CTD PMID:23056601 NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:132,940,862...132,947,963
JBrowse link
G Krt33a keratin 33A multiple interactions
increases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein]]; Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein] CTD PMID:23056601 NCBI chr10:84,942,584...84,947,544
Ensembl chr10:84,942,573...84,947,478
JBrowse link
G Krt5 keratin 5 decreases expression EXP Morphine results in decreased expression of KRT5 protein CTD PMID:23056601 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Krt8 keratin 8 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein]]; Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein] CTD PMID:23056601 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Morphine results in increased expression of LCN2 mRNA CTD PMID:20144693 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lepr leptin receptor increases expression ISO Morphine results in increased expression of LEPR mRNA CTD PMID:20144693 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Morphine results in decreased expression of LHB protein CTD PMID:7022252 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO Morphine results in decreased expression of LIN7C mRNA CTD PMID:21955143 NCBI chr 3:96,406,800...96,417,779
Ensembl chr 3:96,406,813...96,417,728
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor decreases expression ISO Morphine results in decreased expression of LITAF mRNA CTD PMID:21955143 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Lmo7 LIM domain 7 increases expression ISO Morphine results in increased expression of LMO7 mRNA CTD PMID:21955143 NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783
JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta increases expression ISO Morphine results in increased expression of LMX1B mRNA CTD PMID:19397953 NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:16,862,195...16,940,899
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Morphine results in increased expression of LPL mRNA CTD PMID:21955143 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Morphine results in decreased expression of LRP1 mRNA CTD PMID:21178816 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression ISO Morphine results in increased expression of LRPPRC mRNA CTD PMID:20144693 NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293
JBrowse link
G Map2 microtubule-associated protein 2 decreases expression EXP Morphine results in decreased expression of MAP2 mRNA CTD PMID:15183518 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
increases phosphorylation
multiple interactions
ISO
EXP
Morphine results in increased expression of MAPK1 protein modified form
Morphine results in increased phosphorylation of MAPK1 protein
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
Morphine deficiency results in increased phosphorylation of MAPK1 protein; Morphine results in increased phosphorylation of MAPK1 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
CTD PMID:15196791 PMID:20359526 PMID:20519536 PMID:21235400 PMID:21483469 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression EXP Morphine results in increased expression of MAPK14 protein CTD PMID:23056601 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine deficiency results in increased phosphorylation of MAPK3 protein; Morphine results in increased phosphorylation of MAPK3 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
CTD PMID:20519536 PMID:21235400 PMID:21483469 PMID:21600884 PMID:23965172 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau increases expression EXP Morphine results in increased expression of MAPT mRNA CTD PMID:15183518 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression EXP Morphine results in decreased expression of MARCKS protein CTD PMID:23056601 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
JBrowse link
G Mavs mitochondrial antiviral signaling protein increases expression EXP Morphine results in increased expression of MAVS protein CTD PMID:23056601 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094
JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 affects expression ISO Morphine affects the expression of MBD1 mRNA CTD PMID:33891991 NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 decreases expression ISO Morphine results in decreased expression of MBD3 mRNA CTD PMID:33891991 NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165
JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase affects expression ISO Morphine affects the expression of MBD4 mRNA CTD PMID:33891991 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Morphine results in increased expression of MCL1 mRNA CTD PMID:20144693 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression ISO Morphine results in increased expression of MCTP1 mRNA CTD PMID:21955143 NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833
JBrowse link
G Me3 malic enzyme 3 increases expression ISO Morphine results in increased expression of ME3 mRNA CTD PMID:21178816 NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132
JBrowse link
G Mir107 microRNA 107 decreases expression ISO Morphine results in decreased expression of MIR107 CTD PMID:20564181 NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853
JBrowse link
G Mir132 microRNA 132 increases expression ISO Morphine results in increased expression of MIR132 CTD PMID:20564181 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
JBrowse link
G Mir146a microRNA 146a increases expression ISO Morphine results in increased expression of MIR146A CTD PMID:20564181 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir150 microRNA 150 increases expression ISO Morphine results in increased expression of MIR150 CTD PMID:20564181 NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108
JBrowse link
G Mir155 microRNA 155 increases expression ISO Morphine results in increased expression of MIR155 CTD PMID:20564181 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir15b microRNA 15b increases expression ISO Morphine results in increased expression of MIR15B CTD PMID:20564181 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
JBrowse link
G Mir191 microRNA 191 decreases expression ISO Morphine results in decreased expression of MIR191 CTD PMID:20564181 NCBI chr 8:109,264,098...109,264,188 JBrowse link
G Mir21 microRNA 21 decreases expression ISO Morphine results in decreased expression of MIR21 CTD PMID:20564181 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir221 microRNA 221 increases expression ISO Morphine results in increased expression of MIR221 CTD PMID:20564181 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573
JBrowse link
G Mir23a microRNA 23a increases expression ISO Morphine results in increased expression of MIR23A CTD PMID:20564181 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071
JBrowse link
G Mir23b microRNA 23b increases expression ISO Morphine results in increased expression of MIR23B CTD PMID:20564181 NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763
JBrowse link
G Mir26a microRNA 26a decreases expression ISO Morphine results in decreased expression of MIR26A1 CTD PMID:20564181 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378
JBrowse link
G Mir26b microRNA 26b decreases expression ISO Morphine results in decreased expression of MIR26B CTD PMID:20564181 NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680
JBrowse link
G Mir320a microRNA 320a decreases expression ISO Morphine results in decreased expression of MIR320A CTD PMID:20564181 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
JBrowse link
G Mir423 microRNA 423 decreases expression ISO Morphine results in decreased expression of MIR423 CTD PMID:20564181 NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226
JBrowse link
G Mir99b microRNA 99b decreases expression ISO Morphine results in decreased expression of MIR99B CTD PMID:20564181 NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions
increases activity
EXP Naloxone inhibits the reaction [Morphine results in increased activity of MME protein]; phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases activity
ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine results in increased activity of MMP9 protein
CTD PMID:20519536 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Morphine results in increased expression of MPEG1 mRNA CTD PMID:21178816 NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855
JBrowse link
G Myo19 myosin XIX decreases expression ISO Morphine results in decreased expression of MYO19 mRNA CTD PMID:21178816 NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression EXP Morphine results in increased expression of NAIP mRNA CTD PMID:15183518 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542
JBrowse link
G Nav1 neuron navigator 1 decreases expression ISO Morphine results in decreased expression of NAV1 mRNA CTD PMID:21178816 NCBI chr13:46,866,972...47,119,368
Ensembl chr13:46,873,689...47,126,449
JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression EXP Morphine results in decreased expression of NCAM1 protein modified form CTD PMID:15673448 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 affects expression ISO Morphine affects the expression of NDUFAB1 mRNA CTD PMID:20144693 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Morphine results in increased expression of NDUFV2 protein CTD PMID:23056601 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
JBrowse link
G Nefh neurofilament heavy chain increases expression EXP Morphine results in increased expression of NEFH mRNA CTD PMID:15183518 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nes nestin decreases expression ISO Morphine results in decreased expression of NES mRNA CTD PMID:26877219 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP Morphine results in increased expression of NFKB1 mRNA CTD PMID:15183518 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
affects response to substance
increases expression
increases degradation
multiple interactions
ISO
EXP
Morphine results in increased phosphorylation of NFKBIA protein
NFKBIA protein affects the susceptibility to Morphine
Morphine results in increased expression of NFKBIA protein
Morphine results in increased degradation of NFKBIA protein
Morphine results in increased expression of NFKBIA mRNA; Morphine results in increased expression of NFKBIA protein
Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Cycloheximide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Morphine inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
CTD PMID:17542780 PMID:19070643 PMID:22258905 PMID:24068670 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ninj1 ninjurin 1 increases expression ISO Morphine results in increased expression of NINJ1 mRNA CTD PMID:19397953 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
ISO corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]] CTD PMID:37394652 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
increases expression
ISO
EXP
[7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]
Morphine results in decreased expression of NOS1 protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]
CTD PMID:16598705 PMID:20519536 PMID:20568289 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
affects response to substance
ISO Morphine results in increased expression of NOS2 mRNA; Morphine results in increased expression of NOS2 protein
corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of NOS2 protein]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]
NOS2 protein affects the susceptibility to Morphine
CTD PMID:11590188 PMID:15220775 PMID:16325209 PMID:19751225 PMID:24756886 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npy neuropeptide Y increases expression ISO Morphine results in increased expression of NPY mRNA CTD PMID:20144693 PMID:21178816 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Npy1r neuropeptide Y receptor Y1 decreases expression ISO Morphine results in decreased expression of NPY1R mRNA CTD PMID:20144693 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP [Mifepristone binds to and results in decreased activity of NR3C1 protein] which results in decreased susceptibility to Morphine CTD PMID:15014116 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Morphine results in increased expression of NR4A1 mRNA CTD PMID:21955143 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions
decreases expression
affects response to substance
ISO
EXP
BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]
Morphine results in decreased expression of NR4A2 mRNA
Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]
CTD PMID:25643298 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nrcam neuronal cell adhesion molecule increases expression EXP Morphine results in increased expression of NRCAM mRNA; Morphine results in increased expression of NRCAM mRNA alternative form CTD PMID:16123759 NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
JBrowse link
G Nrn1 neuritin 1 decreases expression ISO Morphine results in decreased expression of NRN1 mRNA CTD PMID:21955143 NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,129,977...28,138,896
JBrowse link
G Nrxn3 neurexin 3 increases expression ISO Morphine results in increased expression of NRXN3 mRNA CTD PMID:21955143 NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044
JBrowse link
G Ntng1 netrin G1 decreases expression ISO Morphine results in decreased expression of NTNG1 mRNA CTD PMID:21955143 NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997
JBrowse link
G Ntsr1 neurotensin receptor 1 affects response to substance ISO NTSR1 protein affects the susceptibility to Morphine CTD PMID:20727387 NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377
JBrowse link
G Opalin oligodendrocytic myelin paranodal and inner loop protein decreases expression ISO Morphine results in decreased expression of OPALIN mRNA CTD PMID:21955143 NCBI chr 1:239,891,137...239,909,388
Ensembl chr 1:239,891,142...239,908,788
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
increases expression
affects binding
ISO