CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | opioid agent |
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Accession: | CHEBI:60598
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browse the term
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Definition: | Any agent that acts on an opioid receptor or affects the life cycle of an opioid transmitter. |
Synonyms: | related_synonym: | opioid agents |
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Adra1a |
adrenoceptor alpha 1A |
increases expression |
EXP |
Tramadol results in increased expression of ADRA1A protein |
CTD |
PMID:15464068 |
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NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions increases expression |
EXP |
Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein] |
CTD |
PMID:31618080 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
Tramadol results in increased expression of BAX protein |
CTD |
PMID:25550769 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bche |
butyrylcholinesterase |
decreases activity |
EXP |
Tramadol results in decreased activity of BCHE protein |
CTD |
PMID:28689766 |
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NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Casp3 |
caspase 3 |
affects activity multiple interactions increases expression decreases activity |
ISO EXP |
Tramadol affects the activity of CASP3 protein Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein] Tramadol results in decreased activity of CASP3 protein |
CTD |
PMID:27317026 PMID:28499616 PMID:31618080 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat |
catalase |
decreases expression multiple interactions |
EXP |
Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA] |
CTD |
PMID:25550769 PMID:31618080 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ckb |
creatine kinase B |
decreases expression multiple interactions |
ISO EXP |
Tramadol results in decreased expression of CKB mRNA Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein] |
CTD |
PMID:27317026 PMID:33645892 |
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NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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Ckm |
creatine kinase, M-type |
multiple interactions |
EXP |
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein] |
CTD |
PMID:33645892 |
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NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Tramadol results in decreased activity of CYP17A1 protein |
CTD |
PMID:29100959 |
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
affects metabolic processing affects methylation multiple interactions decreases methylation affects response to substance decreases response to substance increases response to substance increases metabolic processing |
ISO |
CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol CYP2D6 protein affects the methylation of Tramadol [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol CYP2D6 protein results in decreased methylation of Tramadol CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CYP2D6 gene mutant form results in increased susceptibility to Tramadol CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol |
CTD |
PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 PMID:17361124 PMID:17470523 PMID:17570739 PMID:18204346 PMID:18520597 PMID:18713907 PMID:29555325 PMID:31173123 More...
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Des |
desmin |
multiple interactions |
EXP |
Tramadol promotes the reaction [Ethanol results in increased expression of DES protein] |
CTD |
PMID:33645892 |
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NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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Drd2 |
dopamine receptor D2 |
increases expression |
EXP |
Tramadol results in increased expression of DRD2 protein |
CTD |
PMID:15464068 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Drd3 |
dopamine receptor D3 |
increases expression |
EXP |
Tramadol results in increased expression of DRD3 protein |
CTD |
PMID:15464068 |
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NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
EXP |
Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein] |
CTD |
PMID:33645892 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions increases expression |
EXP |
Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein] |
CTD |
PMID:31618080 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpt |
glutamic--pyruvic transaminase |
increases activity multiple interactions increases expression |
EXP |
Tramadol results in increased activity of GPT protein Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein] |
CTD |
PMID:28689766 PMID:31618080 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Htr2a |
5-hydroxytryptamine receptor 2A |
increases activity increases expression multiple interactions |
EXP |
Tramadol results in increased activity of HTR2A protein Tramadol results in increased expression of HTR2A mRNA Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein] |
CTD |
PMID:18417104 |
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NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Ifng |
interferon gamma |
multiple interactions |
EXP |
Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein] |
CTD |
PMID:33645892 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ldha |
lactate dehydrogenase A |
decreases expression |
ISO |
Tramadol results in decreased expression of LDHA mRNA |
CTD |
PMID:27317026 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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Ndufs1 |
NADH:ubiquinone oxidoreductase core subunit S1 |
decreases expression |
ISO |
Tramadol results in decreased expression of NDUFS1 mRNA |
CTD |
PMID:27317026 |
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NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
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Oprd1 |
opioid receptor, delta 1 |
affects binding multiple interactions |
EXP |
Tramadol binds to OPRD1 protein [Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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Oprk1 |
opioid receptor, kappa 1 |
affects binding multiple interactions |
EXP |
Tramadol binds to OPRK1 protein [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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Oprm1 |
opioid receptor, mu 1 |
affects binding multiple interactions |
EXP |
Tramadol binds to OPRM1 protein [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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Pdk3 |
pyruvate dehydrogenase kinase 3 |
increases expression |
ISO |
Tramadol results in increased expression of PDK3 mRNA |
CTD |
PMID:27317026 |
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NCBI chr X:58,486,699...58,553,533
Ensembl chr X:58,486,554...58,553,557
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Pdyn |
prodynorphin |
decreases expression |
EXP |
Tramadol results in decreased expression of PDYN mRNA |
CTD |
PMID:17401159 |
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NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
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Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
EXP |
[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA |
CTD |
PMID:31276069 |
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NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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Prkaa2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
multiple interactions |
EXP |
[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA |
CTD |
PMID:31276069 |
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NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
EXP |
Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] |
CTD |
PMID:11723065 |
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Sod1 |
superoxide dismutase 1 |
decreases expression multiple interactions |
EXP |
Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA] |
CTD |
PMID:25550769 PMID:31618080 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2 |
superoxide dismutase 2 |
multiple interactions decreases expression |
EXP |
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA] Tramadol results in decreased expression of SOD2 mRNA |
CTD |
PMID:25550769 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Spp1 |
secreted phosphoprotein 1 |
multiple interactions increases expression |
EXP |
Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein] |
CTD |
PMID:33645892 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Tnf |
tumor necrosis factor |
multiple interactions increases expression |
EXP |
[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein] |
CTD |
PMID:17377112 PMID:31618080 PMID:33645892 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnni3 |
troponin I3, cardiac type |
multiple interactions increases expression |
EXP |
Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein] |
CTD |
PMID:33645892 |
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NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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Vim |
vimentin |
multiple interactions |
EXP |
Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein] |
CTD |
PMID:33645892 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Cyb5a |
cytochrome b5 type A |
multiple interactions |
ISO |
CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]; CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil] |
CTD |
PMID:15557344 |
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NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
affects metabolic processing multiple interactions |
ISO |
CYP3A4 protein affects the metabolism of Alfentanil CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil] |
CTD |
PMID:15557344 PMID:15731592 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions affects metabolic processing |
ISO |
CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil] |
CTD |
PMID:15557344 PMID:15731592 PMID:17554244 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Htr3a |
5-hydroxytryptamine receptor 3A |
affects activity |
ISO |
Alfentanil affects the activity of HTR3A protein |
CTD |
PMID:18635474 |
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NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
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Bdnf |
brain-derived neurotrophic factor |
decreases expression |
EXP |
Buprenorphine results in decreased expression of BDNF protein |
CTD |
PMID:24321744 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Cat |
catalase |
decreases activity multiple interactions |
EXP ISO |
Buprenorphine results in decreased activity of CAT protein [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Buprenorphine] results in increased activity of CAT protein |
CTD |
PMID:25683329 PMID:32113805 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Creb1 |
cAMP responsive element binding protein 1 |
decreases phosphorylation |
EXP |
Buprenorphine results in decreased phosphorylation of CREB1 protein |
CTD |
PMID:24321744 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
affects metabolic processing |
ISO |
CYP2C8 protein affects the metabolism of Buprenorphine |
CTD |
PMID:16010532 |
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Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
increases metabolic processing decreases activity |
ISO |
CYP2D6 protein results in increased metabolism of Buprenorphine Buprenorphine results in decreased activity of CYP2D6 protein |
CTD |
PMID:12756210 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
affects metabolic processing decreases alkylation increases metabolic processing decreases activity |
ISO |
CYP3A4 protein affects the metabolism of Buprenorphine CYP3A4 protein results in decreased alkylation of Buprenorphine CYP3A4 protein results in increased metabolism of Buprenorphine Buprenorphine results in decreased activity of CYP3A4 protein |
CTD |
PMID:12756210 PMID:15966752 PMID:16010532 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Gpt |
glutamic--pyruvic transaminase |
increases activity |
EXP |
Buprenorphine results in increased activity of GPT protein |
CTD |
PMID:25683329 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Il2 |
interleukin 2 |
decreases expression |
ISO |
Buprenorphine results in decreased expression of IL2 mRNA |
CTD |
PMID:23965172 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il4 |
interleukin 4 |
increases expression |
ISO |
Buprenorphine results in increased expression of IL4 mRNA |
CTD |
PMID:23965172 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
Buprenorphine results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:23965172 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
Buprenorphine results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:23965172 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Ntrk2 |
neurotrophic receptor tyrosine kinase 2 |
decreases phosphorylation |
EXP |
Buprenorphine results in decreased phosphorylation of NTRK2 protein |
CTD |
PMID:24321744 |
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NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Oprd1 |
opioid receptor, delta 1 |
affects binding multiple interactions |
EXP ISO |
Buprenorphine binds to OPRD1 protein Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein] |
CTD |
PMID:7562497 PMID:21866885 |
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NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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Oprk1 |
opioid receptor, kappa 1 |
affects binding multiple interactions |
EXP ISO |
Buprenorphine binds to OPRK1 protein Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein] |
CTD |
PMID:7562497 PMID:21866885 |
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NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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Oprl1 |
opioid related nociceptin receptor 1 |
multiple interactions |
ISO |
Buprenorphine binds to and results in increased activity of OPRL1 protein |
CTD |
PMID:10998549 |
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NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
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Oprm1 |
opioid receptor, mu 1 |
multiple interactions affects binding |
ISO EXP |
Buprenorphine binds to and affects the activity of OPRM1 protein; Buprenorphine binds to and results in increased activity of OPRM1 protein; Buprenorphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein] Buprenorphine binds to OPRM1 protein |
CTD |
PMID:7562497 PMID:16010532 PMID:21866885 |
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NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
decreases activity |
EXP |
Buprenorphine results in decreased activity of PRKACA protein |
CTD |
PMID:24321744 |
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NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of Buprenorphine |
CTD |
PMID:12756209 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Oprd1 |
opioid receptor, delta 1 |
affects activity |
EXP |
Butorphanol affects the activity of OPRD1 protein |
CTD |
PMID:17909753 |
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NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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Oprk1 |
opioid receptor, kappa 1 |
affects activity |
EXP |
Butorphanol affects the activity of OPRK1 protein |
CTD |
PMID:17909753 |
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NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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G |
Oprm1 |
opioid receptor, mu 1 |
affects activity increases activity |
ISO EXP |
Butorphanol affects the activity of OPRM1 protein Butorphanol results in increased activity of OPRM1 protein |
CTD |
PMID:17909753 PMID:32734307 |
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NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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G |
Prkcd |
protein kinase C, delta |
affects localization |
ISO |
Butorphanol affects the localization of PRKCD protein |
CTD |
PMID:29669290 |
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NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
increases metabolic processing |
ISO |
CYP2C8 protein results in increased metabolism of carfentanil |
CTD |
PMID:33652071 |
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases metabolic processing |
ISO |
CYP3A4 protein results in increased metabolism of carfentanil |
CTD |
PMID:33652071 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases metabolic processing |
ISO |
CYP3A5 protein results in increased metabolism of carfentanil |
CTD |
PMID:33652071 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Oprm1 |
opioid receptor, mu 1 |
multiple interactions |
ISO |
Capsaicin inhibits the reaction [carfentanil binds to OPRM1 protein]; Cocaine affects the reaction [carfentanil binds to OPRM1 protein] |
CTD |
PMID:12406535 PMID:15953495 |
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NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases secretion |
ISO |
Codeine results in increased secretion of CCL2 protein |
CTD |
PMID:17441793 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Codeine affects the secretion of and affects the expression of CCL5 protein |
CTD |
PMID:17441793 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ces2h |
carboxylesterase 2H |
increases hydrolysis |
ISO |
CES2 protein results in increased hydrolysis of Codeine analog |
CTD |
PMID:25445008 |
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NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
affects metabolic processing multiple interactions increases metabolic processing affects response to substance decreases methylation |
ISO |
CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine [CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CYP2D6 protein polymorphism affects the susceptibility to Codeine CYP2D6 protein results in decreased methylation of Codeine CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine |
CTD |
PMID:9696456 PMID:10911933 PMID:11823760 PMID:15286053 PMID:15625333 PMID:16595712 PMID:17470523 PMID:17564651 PMID:21241245 More...
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
affects metabolic processing increases metabolic processing multiple interactions |
ISO |
CYP3A4 protein affects the metabolism of Codeine CYP3A4 protein results in increased metabolism of Codeine [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine |
CTD |
PMID:15286053 PMID:16595712 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Codeine results in decreased activity of KCNH2 protein |
CTD |
PMID:19034038 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Oprd1 |
opioid receptor, delta 1 |
affects binding |
EXP |
Codeine binds to OPRD1 protein |
CTD |
PMID:7562497 |
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NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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G |
Oprk1 |
opioid receptor, kappa 1 |
affects binding |
EXP |
Codeine binds to OPRK1 protein |
CTD |
PMID:7562497 |
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NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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G |
Oprm1 |
opioid receptor, mu 1 |
affects binding |
EXP |
Codeine binds to OPRM1 protein |
CTD |
PMID:7562497 |
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NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
6-codeinone results in increased expression of BAX protein |
CTD |
PMID:12894543 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
6-codeinone results in decreased expression of BCL2 protein |
CTD |
PMID:12894543 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
increases activity increases cleavage |
ISO |
6-codeinone results in increased activity of CASP3 protein 6-codeinone results in increased cleavage of CASP3 protein |
CTD |
PMID:12606908 PMID:12894543 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
increases activity |
ISO |
6-codeinone results in increased activity of CASP9 protein |
CTD |
PMID:12894543 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cycs |
cytochrome c, somatic |
affects localization |
ISO |
6-codeinone affects the localization of CYCS protein |
CTD |
PMID:12894543 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
affects response to substance |
ISO |
ABCB1A protein affects the susceptibility to Dextropropoxyphene |
CTD |
PMID:15502009 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
affects response to substance |
ISO |
ABCB1B protein affects the susceptibility to Dextropropoxyphene |
CTD |
PMID:15502009 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Ces1d |
carboxylesterase 1D |
affects binding |
ISO |
Dextropropoxyphene binds to CES1 protein |
CTD |
PMID:10381793 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Ces2h |
carboxylesterase 2H |
affects binding |
ISO |
Dextropropoxyphene binds to CES2 protein |
CTD |
PMID:10381793 |
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NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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G |
Oprd1 |
opioid receptor, delta 1 |
multiple interactions affects binding |
EXP |
[Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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G |
Oprk1 |
opioid receptor, kappa 1 |
multiple interactions affects binding |
EXP |
[Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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G |
Oprm1 |
opioid receptor, mu 1 |
multiple interactions affects binding |
EXP |
[Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Dextropropoxyphene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
affects export |
EXP |
ABCC2 protein affects the export of Enkephalin, D-Penicillamine (2,5)- |
CTD |
PMID:15528320 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Cckbr |
cholecystokinin B receptor |
affects response to substance |
ISO |
CCKBR protein affects the susceptibility to Enkephalin, D-Penicillamine (2,5)- |
CTD |
PMID:11880531 |
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NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
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G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
increases secretion |
ISO |
HNF4A protein results in increased secretion of Enkephalin, D-Penicillamine (2,5)- |
CTD |
PMID:27160211 |
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NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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G |
Oprd1 |
opioid receptor, delta 1 |
multiple interactions affects binding increases expression |
EXP ISO |
[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum; [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine; naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine] 7-hydroxymitragynine affects the reaction [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein]; Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]; Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein Enkephalin, D-Penicillamine (2,5)- binds to OPRD1 protein Enkephalin, D-Penicillamine (2,5)- results in increased expression of OPRD1 mRNA |
CTD |
PMID:7477890 PMID:7562497 PMID:9302088 PMID:19279569 PMID:21866885 PMID:27192616 More...
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NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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G |
Oprk1 |
opioid receptor, kappa 1 |
affects binding |
EXP |
Enkephalin, D-Penicillamine (2,5)- binds to OPRK1 protein |
CTD |
PMID:7562497 |
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NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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G |
Oprm1 |
opioid receptor, mu 1 |
affects binding |
EXP |
Enkephalin, D-Penicillamine (2,5)- binds to OPRM1 protein |
CTD |
PMID:7562497 |
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NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
affects transport affects uptake |
ISO EXP |
SLCO1A4 protein affects the transport of Enkephalin, D-Penicillamine (2,5)- SLCO1A4 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)- |
CTD |
PMID:15528320 PMID:19833843 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
affects uptake |
EXP |
SLCO1B2 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)- |
CTD |
PMID:15528320 |
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NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Oprd1 |
opioid receptor, delta 1 |
affects response to substance |
ISO |
OPRD1 protein affects the susceptibility to eluxadoline |
CTD |
PMID:25261794 |
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NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport multiple interactions increases response to substance |
ISO EXP |
ABCB1 protein results in increased transport of Fentanyl tariquidar inhibits the reaction [ABCB1 protein results in increased transport of Fentanyl] ABCB1 protein results in increased susceptibility to Fentanyl |
CTD |
PMID:29669042 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Acan |
aggrecan |
decreases expression |
EXP |
Fentanyl results in decreased expression of ACAN mRNA |
CTD |
PMID:36032789 |
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NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
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G |
Adamts14 |
ADAM metallopeptidase with thrombospondin type 1 motif, 14 |
decreases expression |
EXP |
Fentanyl results in decreased expression of ADAMTS14 mRNA |
CTD |
PMID:36032789 |
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NCBI chr20:29,143,029...29,219,846
Ensembl chr20:29,144,354...29,219,866
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G |
Adamtsl3 |
ADAMTS-like 3 |
affects expression |
EXP |
Fentanyl affects the expression of ADAMTSL3 mRNA |
CTD |
PMID:36032789 |
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NCBI chr 1:136,288,793...136,596,986
Ensembl chr 1:136,288,793...136,596,986
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G |
Akap5 |
A-kinase anchoring protein 5 |
increases expression |
EXP |
Fentanyl results in increased expression of AKAP5 mRNA |
CTD |
PMID:36032789 |
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NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
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G |
Apln |
apelin |
decreases expression |
EXP |
Fentanyl results in decreased expression of APLN mRNA |
CTD |
PMID:36032789 |
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NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391
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G |
Arrb2 |
arrestin, beta 2 |
affects localization multiple interactions |
ISO EXP |
Fentanyl affects the localization of ARRB2 protein [Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein |
CTD |
PMID:27030709 PMID:35477798 |
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NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
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G |
Bdnf |
brain-derived neurotrophic factor |
affects expression |
EXP |
Fentanyl affects the expression of BDNF mRNA |
CTD |
PMID:36032789 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Bgn |
biglycan |
affects expression |
EXP |
Fentanyl affects the expression of BGN mRNA |
CTD |
PMID:36032789 |
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NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
increases expression |
EXP |
Fentanyl results in increased expression of BIRC3 mRNA |
CTD |
PMID:36032789 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Bst2 |
bone marrow stromal cell antigen 2 |
increases expression |
EXP |
Fentanyl results in increased expression of BST2 mRNA |
CTD |
PMID:36032789 |
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NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979
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G |
C3 |
complement C3 |
increases expression |
EXP |
Fentanyl results in increased expression of C3 mRNA |
CTD |
PMID:36032789 |
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NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
Cacna1e |
calcium voltage-gated channel subunit alpha1 E |
affects expression |
EXP |
Fentanyl affects the expression of CACNA1E mRNA |
CTD |
PMID:36032789 |
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NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
EXP |
Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]] |
CTD |
PMID:27030709 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Cckbr |
cholecystokinin B receptor |
decreases expression |
EXP |
Fentanyl results in decreased expression of CCKBR mRNA |
CTD |
PMID:36032789 |
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NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
EXP |
Fentanyl results in increased expression of CCL2 mRNA |
CTD |
PMID:36032789 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
increases expression |
EXP |
Fentanyl results in increased expression of CCL20 mRNA |
CTD |
PMID:36032789 |
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NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
increases expression |
EXP |
Fentanyl results in increased expression of CCL7 mRNA |
CTD |
PMID:36032789 |
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NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
Cfb |
complement factor B |
increases expression |
EXP |
Fentanyl results in increased expression of CFB mRNA |
CTD |
PMID:36032789 |
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NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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G |
Chi3l1 |
chitinase 3 like 1 |
increases expression |
EXP |
Fentanyl results in increased expression of CHI3L1 mRNA |
CTD |
PMID:36032789 |
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NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787
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G |
Clstn2 |
calsyntenin 2 |
affects expression |
EXP |
Fentanyl affects the expression of CLSTN2 mRNA |
CTD |
PMID:36032789 |
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NCBI chr 8:98,020,406...98,637,232
Ensembl chr 8:98,021,666...98,637,731
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G |
Cntf |
ciliary neurotrophic factor |
increases expression |
EXP |
Fentanyl results in increased expression of CNTF mRNA |
CTD |
PMID:36032789 |
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NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
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G |
Col15a1 |
collagen type XV alpha 1 chain |
increases expression |
EXP |
Fentanyl results in increased expression of COL15A1 mRNA |
CTD |
PMID:36032789 |
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NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591
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G |
Col26a1 |
collagen type XXVI alpha 1 chain |
increases expression |
EXP |
Fentanyl results in increased expression of COL26A1 mRNA |
CTD |
PMID:36032789 |
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NCBI chr12:19,792,693...19,938,556
Ensembl chr12:19,792,728...19,938,556
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G |
Col3a1 |
collagen type III alpha 1 chain |
affects expression |
EXP |
Fentanyl affects the expression of COL3A1 mRNA |
CTD |
PMID:36032789 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Crh |
corticotropin releasing hormone |
affects expression increases expression |
EXP |
Fentanyl affects the expression of CRH mRNA Fentanyl results in increased expression of CRH mRNA |
CTD |
PMID:18819432 PMID:36032789 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Crlf1 |
cytokine receptor-like factor 1 |
affects expression |
EXP |
Fentanyl affects the expression of CRLF1 mRNA |
CTD |
PMID:36032789 |
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NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997
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G |
Csf1 |
colony stimulating factor 1 |
increases expression |
EXP |
Fentanyl results in increased expression of CSF1 mRNA |
CTD |
PMID:36032789 |
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NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases expression |
EXP |
Fentanyl results in increased expression of CXCL1 mRNA |
CTD |
PMID:36032789 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
increases expression |
EXP |
Fentanyl results in increased expression of CXCL10 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl11 |
C-X-C motif chemokine ligand 11 |
increases expression |
EXP |
Fentanyl results in increased expression of CXCL11 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
increases expression |
EXP |
Fentanyl results in increased expression of CXCL12 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl13 |
C-X-C motif chemokine ligand 13 |
increases expression |
EXP |
Fentanyl results in increased expression of CXCL13 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
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G |
Cxcl16 |
C-X-C motif chemokine ligand 16 |
increases expression |
EXP |
Fentanyl results in increased expression of CXCL16 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases activity |
ISO |
Fentanyl results in increased activity of CYP2B6 protein |
CTD |
PMID:35914676 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases metabolic processing |
ISO |
CYP3A4 protein results in increased metabolism of Fentanyl |
CTD |
PMID:11811955 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Dcn |
decorin |
increases expression |
EXP |
Fentanyl results in increased expression of DCN mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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G |
Ednrb |
endothelin receptor type B |
decreases expression |
EXP |
Fentanyl results in decreased expression of EDNRB mRNA |
CTD |
PMID:36032789 |
|
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Fbln5 |
fibulin 5 |
decreases expression |
EXP |
Fentanyl results in decreased expression of FBLN5 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755
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G |
Fgr |
FGR proto-oncogene, Src family tyrosine kinase |
increases expression |
EXP |
Fentanyl results in increased expression of FGR mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Fentanyl results in increased expression of FOS protein |
CTD |
PMID:7970238 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gast |
gastrin |
multiple interactions |
EXP |
[fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine] |
CTD |
PMID:10864877 |
|
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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G |
Gbp2 |
guanylate binding protein 2 |
increases expression |
EXP |
Fentanyl results in increased expression of GBP2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
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G |
Grem1 |
gremlin 1, DAN family BMP antagonist |
decreases expression |
EXP |
Fentanyl results in decreased expression of GREM1 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
affects expression |
EXP |
Fentanyl affects the expression of GRIN2A mRNA |
CTD |
PMID:36032789 |
|
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
affects expression |
EXP |
Fentanyl affects the expression of GRIN2B mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Grm1 |
glutamate metabotropic receptor 1 |
affects expression |
EXP |
Fentanyl affects the expression of GRM1 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
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G |
Grm3 |
glutamate metabotropic receptor 3 |
affects expression |
EXP |
Fentanyl affects the expression of GRM3 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804
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|
G |
Has1 |
hyaluronan synthase 1 |
decreases expression |
EXP |
Fentanyl results in decreased expression of HAS1 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397
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G |
Hcrtr1 |
hypocretin receptor 1 |
decreases expression |
EXP |
Fentanyl results in decreased expression of HCRTR1 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
affects expression |
EXP |
Fentanyl affects the expression of HTR2A mRNA |
CTD |
PMID:36032789 |
|
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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G |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
increases expression |
EXP |
Fentanyl results in increased expression of IFIT3 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
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G |
Il1a |
interleukin 1 alpha |
increases expression |
EXP |
Fentanyl results in increased expression of IL1A mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il2 |
interleukin 2 |
decreases expression |
ISO |
Fentanyl results in decreased expression of IL2 mRNA |
CTD |
PMID:23965172 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il4 |
interleukin 4 |
increases expression |
ISO |
Fentanyl results in increased expression of IL4 mRNA |
CTD |
PMID:23965172 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il7 |
interleukin 7 |
increases expression |
EXP |
Fentanyl results in increased expression of IL7 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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G |
Irf7 |
interferon regulatory factor 7 |
increases expression |
EXP |
Fentanyl results in increased expression of IRF7 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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G |
Isg15 |
ISG15 ubiquitin-like modifier |
increases expression |
EXP |
Fentanyl results in increased expression of ISG15 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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|
G |
Itga11 |
integrin subunit alpha 11 |
increases expression |
EXP |
Fentanyl results in increased expression of ITGA11 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407
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G |
Itgal |
integrin subunit alpha L |
increases expression |
EXP |
Fentanyl results in increased expression of ITGAL mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Fentanyl results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Lamb3 |
laminin subunit beta 3 |
decreases expression |
EXP |
Fentanyl results in decreased expression of LAMB3 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
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G |
Lamc2 |
laminin subunit gamma 2 |
affects expression |
EXP |
Fentanyl affects the expression of LAMC2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
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G |
Lcn2 |
lipocalin 2 |
increases expression |
EXP |
Fentanyl results in increased expression of LCN2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lox |
lysyl oxidase |
decreases expression |
EXP |
Fentanyl results in decreased expression of LOX mRNA |
CTD |
PMID:36032789 |
|
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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G |
Loxl1 |
lysyl oxidase-like 1 |
increases expression |
EXP |
Fentanyl results in increased expression of LOXL1 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356
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G |
Loxl2 |
lysyl oxidase-like 2 |
decreases expression |
EXP |
Fentanyl results in decreased expression of LOXL2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067
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G |
Ltb |
lymphotoxin beta |
increases expression |
EXP |
Fentanyl results in increased expression of LTB mRNA |
CTD |
PMID:36032789 |
|
NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
Fentanyl results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:23965172 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
Fentanyl results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:23965172 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
decreases expression |
EXP |
Fentanyl results in decreased expression of MAS1 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
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G |
Mmp2 |
matrix metallopeptidase 2 |
increases expression |
EXP |
Fentanyl results in increased expression of MMP2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
EXP |
Fentanyl results in decreased expression of MMP9 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mx1 |
MX dynamin like GTPase 1 |
increases expression |
EXP |
Fentanyl results in increased expression of MX1 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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G |
Mx2 |
MX dynamin like GTPase 2 |
increases expression |
EXP |
Fentanyl results in increased expression of MX2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression |
ISO EXP |
Fentanyl results in increased expression of NFKBIA protein Fentanyl results in increased expression of NFKBIA mRNA |
CTD |
PMID:22258905 PMID:36032789 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nid2 |
nidogen 2 |
decreases expression |
EXP |
Fentanyl results in decreased expression of NID2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843
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G |
Nppc |
natriuretic peptide C |
affects expression |
EXP |
Fentanyl affects the expression of NPPC mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
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G |
Nts |
neurotensin |
decreases expression |
EXP |
Fentanyl results in decreased expression of NTS mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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G |
Oasl |
2'-5'-oligoadenylate synthetase-like |
increases expression |
EXP |
Fentanyl results in increased expression of OASL mRNA |
CTD |
PMID:36032789 |
|
NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
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G |
Oprd1 |
opioid receptor, delta 1 |
affects binding |
EXP |
Fentanyl binds to OPRD1 protein |
CTD |
PMID:35477798 |
|
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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G |
Oprk1 |
opioid receptor, kappa 1 |
affects binding |
EXP |
Fentanyl binds to OPRK1 protein |
CTD |
PMID:35477798 |
|
NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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G |
Oprm1 |
opioid receptor, mu 1 |
increases phosphorylation multiple interactions |
ISO EXP |
Fentanyl results in increased phosphorylation of OPRM1 protein [Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Fentanyl binds to and results in increased activity of OPRM1 protein |
CTD |
PMID:17240843 PMID:21957251 PMID:23300227 PMID:35477798 |
|
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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G |
P4ha2 |
prolyl 4-hydroxylase subunit alpha 2 |
decreases expression |
EXP |
Fentanyl results in decreased expression of P4HA2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,243,139...38,287,314
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G |
Pdyn |
prodynorphin |
increases expression |
EXP |
Fentanyl results in increased expression of PDYN protein |
CTD |
PMID:19200067 |
|
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
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G |
Pf4 |
platelet factor 4 |
increases expression |
EXP |
Fentanyl results in increased expression of PF4 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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G |
Pld2 |
phospholipase D2 |
increases activity |
ISO |
Fentanyl results in increased activity of PLD2 protein |
CTD |
PMID:23965172 |
|
NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
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G |
Pomc |
proopiomelanocortin |
decreases expression multiple interactions |
ISO |
Fentanyl results in decreased expression of POMC protein alternative form [Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form |
CTD |
PMID:20084599 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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|
G |
Prlhr |
prolactin releasing hormone receptor |
decreases expression |
EXP |
Fentanyl results in decreased expression of PRLHR mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 1:259,606,704...259,608,391
Ensembl chr 1:259,606,704...259,608,391
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G |
Psmb9 |
proteasome 20S subunit beta 9 |
increases expression |
EXP |
Fentanyl results in increased expression of PSMB9 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
|
|
G |
Pthlh |
parathyroid hormone-like hormone |
affects expression |
EXP |
Fentanyl affects the expression of PTHLH mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
|
|
G |
Ptx3 |
pentraxin 3 |
increases expression |
EXP |
Fentanyl results in increased expression of PTX3 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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|
G |
Reln |
reelin |
increases expression |
EXP |
Fentanyl results in increased expression of RELN mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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G |
Ren |
renin |
multiple interactions |
ISO |
[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein |
CTD |
PMID:3284271 |
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
|
|
G |
S100a8 |
S100 calcium binding protein A8 |
increases expression |
EXP |
Fentanyl results in increased expression of S100A8 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
|
|
G |
Scg2 |
secretogranin II |
affects expression |
EXP |
Fentanyl affects the expression of SCG2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097
|
|
G |
Sema3a |
semaphorin 3A |
decreases expression |
EXP |
Fentanyl results in decreased expression of SEMA3A mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432
|
|
G |
Slc11a1 |
solute carrier family 11 member 1 |
increases expression |
EXP |
Fentanyl results in increased expression of SLC11A1 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101
|
|
G |
Slc8a2 |
solute carrier family 8 member A2 |
affects expression |
EXP |
Fentanyl affects the expression of SLC8A2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 1:76,816,583...76,852,928
Ensembl chr 1:76,808,725...76,847,072
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|
G |
Sod2 |
superoxide dismutase 2 |
increases expression |
EXP |
Fentanyl results in increased expression of SOD2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sorcs3 |
sortilin-related VPS10 domain containing receptor 3 |
decreases expression |
EXP |
Fentanyl results in decreased expression of SORCS3 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 1:247,099,178...247,734,027
Ensembl chr 1:247,099,408...247,734,027
|
|
G |
Spp1 |
secreted phosphoprotein 1 |
affects expression |
EXP |
Fentanyl affects the expression of SPP1 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
|
|
G |
Tlr2 |
toll-like receptor 2 |
increases expression |
EXP |
Fentanyl results in increased expression of TLR2 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
|
|
G |
Tnfrsf9 |
TNF receptor superfamily member 9 |
increases expression |
EXP |
Fentanyl results in increased expression of TNFRSF9 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
|
|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
increases expression |
EXP |
Fentanyl results in increased expression of VCAM1 mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
|
|
G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
EXP |
Fentanyl results in decreased expression of VEGFA mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vgf |
VGF nerve growth factor inducible |
affects expression |
EXP |
Fentanyl affects the expression of VGF mRNA |
CTD |
PMID:36032789 |
|
NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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G |
Wnt10a |
Wnt family member 10A |
affects expression |
EXP |
Fentanyl affects the expression of WNT10A mRNA |
CTD |
PMID:36032789 |
|
NCBI chr 9:76,349,931...76,362,400
Ensembl chr 9:76,349,931...76,362,400
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G |
Ache |
acetylcholinesterase |
multiple interactions increases metabolic processing |
ISO |
[ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine |
CTD |
PMID:30080993 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Actn2 |
actinin alpha 2 |
decreases expression |
ISO |
Heroin results in decreased expression of ACTN2 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622
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G |
Amph |
amphiphysin |
decreases expression |
ISO |
Heroin results in decreased expression of AMPH mRNA |
CTD |
PMID:16710320 |
|
NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315
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G |
App |
amyloid beta precursor protein |
decreases expression |
ISO |
Heroin results in decreased expression of APP mRNA |
CTD |
PMID:16710320 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Bche |
butyrylcholinesterase |
multiple interactions increases metabolic processing |
ISO |
[BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine |
CTD |
PMID:30080993 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Bdnf |
brain-derived neurotrophic factor |
decreases expression multiple interactions |
ISO EXP |
Heroin results in decreased expression of BDNF protein Heroin results in decreased expression of BDNF mRNA Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter] |
CTD |
PMID:17715210 PMID:25643298 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Bloc1s6 |
biogenesis of lysosomal organelles complex 1 subunit 6 |
decreases expression |
ISO |
Heroin results in decreased expression of BLOC1S6 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 3:109,816,397...109,826,528
Ensembl chr 3:109,816,366...109,828,308
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
[Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein] |
CTD |
PMID:20600547 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ces1d |
carboxylesterase 1D |
decreases acetylation increases hydrolysis multiple interactions affects binding |
ISO |
CES1 protein results in decreased acetylation of Heroin CES1 protein results in increased hydrolysis of Heroin Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin] Heroin binds to CES1 protein |
CTD |
PMID:8930175 PMID:9311626 PMID:12679808 PMID:12773168 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Ces2h |
carboxylesterase 2H |
multiple interactions increases hydrolysis |
ISO |
Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin] |
CTD |
PMID:8930175 PMID:9169443 PMID:25445008 |
|
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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G |
Churc1 |
churchill domain containing 1 |
decreases expression |
ISO |
Heroin results in decreased expression of CHURC1 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 6:95,464,488...95,485,208
Ensembl chr 6:95,470,683...95,619,586
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions increases phosphorylation |
EXP |
Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter] heroin increases phosphorylation of Creb1 protein in brain |
CTD RGD |
PMID:25643298 PMID:21362452 |
RGD:401901181 |
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
Heroin results in decreased activity of CYP1A2 protein |
CTD |
PMID:35914676 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases activity |
ISO |
Heroin results in increased activity of CYP2B6 protein |
CTD |
PMID:35914676 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
increases activity |
ISO |
Heroin results in increased activity of CYP2D6 protein |
CTD |
PMID:35914676 |
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Deaf1 |
DEAF1 transcription factor |
decreases expression |
ISO |
Heroin results in decreased expression of DEAF1 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541
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G |
Dnph1 |
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
decreases expression |
ISO |
Heroin results in decreased expression of DNPH1 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022
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G |
Drd2 |
dopamine receptor D2 |
decreases expression |
ISO |
Heroin results in decreased expression of DRD2 protein |
CTD |
PMID:11126397 |
|
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Eif5a |
eukaryotic translation initiation factor 5A |
decreases expression |
ISO |
Heroin results in decreased expression of EIF5A mRNA |
CTD |
PMID:16710320 |
|
NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
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G |
Enho |
energy homeostasis associated |
decreases expression |
ISO |
Heroin results in decreased expression of ENHO mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 5:56,800,980...56,802,777
Ensembl chr 5:56,800,980...56,802,777
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
Heroin results in increased expression of FAS mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP |
Heroin results in increased expression of FOS mRNA; Heroin results in increased expression of FOS protein Dronabinol affects the reaction [Heroin results in increased expression of FOS protein] |
CTD |
PMID:16137723 PMID:19169671 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
EXP |
heroin decreases expression of Fosb protein in brain |
RGD |
PMID:21362452 |
RGD:401901181 |
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Gpt |
glutamic--pyruvic transaminase |
increases expression |
ISO |
Heroin results in increased expression of GPT protein |
CTD |
PMID:36502556 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Cocaine co-treated with Heroin] results in increased expression of IFNG protein |
CTD |
PMID:16766138 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
[Cocaine co-treated with Heroin] results in increased expression of IL10 protein |
CTD |
PMID:16766138 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
[Cocaine co-treated with Heroin] results in increased expression of IL2 protein |
CTD |
PMID:16766138 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
[Cocaine co-treated with Heroin] results in increased expression of IL4 protein |
CTD |
PMID:16766138 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Itgb1bp1 |
integrin subunit beta 1 binding protein 1 |
increases expression |
ISO |
Heroin results in increased expression of ITGB1BP1 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
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G |
Ngf |
nerve growth factor |
decreases expression |
ISO |
Heroin results in decreased expression of NGF protein |
CTD |
PMID:17715210 |
|
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
decreases expression |
EXP |
Heroin results in decreased expression of NR4A2 mRNA |
CTD |
PMID:25643298 |
|
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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G |
Ntrk2 |
neurotrophic receptor tyrosine kinase 2 |
increases expression |
ISO |
Heroin results in increased expression of NTRK2 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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G |
Nucks1 |
nuclear casein kinase and cyclin-dependent kinase substrate 1 |
decreases expression |
ISO |
Heroin results in decreased expression of NUCKS1 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229
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G |
Pde4dip |
phosphodiesterase 4D interacting protein |
increases expression |
ISO |
Heroin results in increased expression of PDE4DIP mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379
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G |
Pdyn |
prodynorphin |
decreases expression increases expression |
ISO EXP |
Heroin results in decreased expression of PDYN mRNA Heroin results in increased expression of PDYN mRNA |
CTD |
PMID:16710320 PMID:19100723 |
|
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
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G |
Pmepa1 |
prostate transmembrane protein, androgen induced 1 |
decreases expression |
ISO |
Heroin results in decreased expression of PMEPA1 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
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G |
Prepl |
prolyl endopeptidase-like |
decreases expression |
ISO |
Heroin results in decreased expression of PREPL mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 6:9,580,367...9,609,957
Ensembl chr 6:9,580,217...9,607,772
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G |
Septin4 |
septin 4 |
increases expression |
ISO |
Heroin results in increased expression of SEPTIN4 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768
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G |
Slc25a23 |
solute carrier family 25 member 23 |
decreases expression |
ISO |
Heroin results in decreased expression of SLC25A23 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 9:1,882,636...1,898,369
Ensembl chr 9:1,882,621...1,898,561
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G |
Slc25a37 |
solute carrier family 25 member 37 |
increases expression |
ISO |
Heroin results in increased expression of SLC25A37 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
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G |
Snap25 |
synaptosome associated protein 25 |
decreases expression |
ISO |
Heroin results in decreased expression of SNAP25 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
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G |
Stxbp1 |
syntaxin binding protein 1 |
decreases expression |
ISO |
Heroin results in decreased expression of STXBP1 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
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G |
Stxbp6 |
syntaxin binding protein 6 |
decreases expression |
ISO |
Heroin results in decreased expression of STXBP6 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024
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G |
Sv2a |
synaptic vesicle glycoprotein 2a |
decreases expression |
ISO |
Heroin results in decreased expression of SV2A mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 2:183,741,489...183,757,290
Ensembl chr 2:183,741,547...183,756,927
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G |
Syngr3 |
synaptogyrin 3 |
decreases expression |
ISO |
Heroin results in decreased expression of SYNGR3 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr10:13,710,553...13,715,309
Ensembl chr10:13,704,998...13,715,669
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G |
Syt1 |
synaptotagmin 1 |
decreases expression |
ISO |
Heroin results in decreased expression of SYT1 mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
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G |
Tfrc |
transferrin receptor |
increases expression |
ISO |
Heroin results in increased expression of TFRC mRNA |
CTD |
PMID:16710320 |
|
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Cocaine co-treated with Heroin] results in increased expression of TNF protein |
CTD |
PMID:16766138 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ugcg |
UDP-glucose ceramide glucosyltransferase |
decreases expression |
ISO |
Heroin results in decreased expression of UGCG mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
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G |
Vti1b |
vesicle transport through interaction with t-SNAREs 1B |
decreases expression |
ISO |
Heroin results in decreased expression of VTI1B mRNA |
CTD |
PMID:16710320 |
|
NCBI chr 6:97,957,700...97,976,491
Ensembl chr 6:97,961,346...97,976,465
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G |
Oprd1 |
opioid receptor, delta 1 |
affects binding |
EXP |
Hydrocodone binds to OPRD1 protein |
CTD |
PMID:7562497 |
|
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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G |
Oprk1 |
opioid receptor, kappa 1 |
affects binding |
EXP |
Hydrocodone binds to OPRK1 protein |
CTD |
PMID:7562497 |
|
NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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G |
Oprm1 |
opioid receptor, mu 1 |
affects binding |
EXP |
Hydrocodone binds to OPRM1 protein |
CTD |
PMID:7562497 |
|
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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G |
Arrb2 |
arrestin, beta 2 |
multiple interactions |
EXP |
[Hydromorphone binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein |
CTD |
PMID:35449307 |
|
NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
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G |
Htr3a |
5-hydroxytryptamine receptor 3A |
affects activity |
ISO |
Hydromorphone affects the activity of HTR3A protein |
CTD |
PMID:18635474 |
|
NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
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G |
Oprm1 |
opioid receptor, mu 1 |
increases activity multiple interactions |
ISO EXP |
Hydromorphone results in increased activity of OPRM1 protein [Hydromorphone binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Hydromorphone binds to and results in increased activity of OPRM1 protein |
CTD |
PMID:32734307 PMID:35449307 PMID:35477798 |
|
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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|
|
G |
Dpp3 |
dipeptidylpeptidase 3 |
increases cleavage multiple interactions |
ISO |
DPP3 protein results in increased cleavage of Enkephalin, Leucine spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine] |
CTD |
PMID:10873616 |
|
NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
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G |
Oprd1 |
opioid receptor, delta 1 |
increases activity |
ISO |
Enkephalin, Leucine results in increased activity of OPRD1 protein |
CTD |
PMID:26476280 |
|
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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G |
Oprm1 |
opioid receptor, mu 1 |
increases activity |
ISO |
Enkephalin, Leucine results in increased activity of OPRM1 protein |
CTD |
PMID:26476280 |
|
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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|
|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases expression |
ISO |
Loperamide results in decreased expression of ABCB11 mRNA |
CTD |
PMID:35926757 |
|
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
affects binding decreases expression multiple interactions increases transport affects response to substance |
ISO |
Loperamide binds to ABCB1 protein Loperamide results in decreased expression of ABCB1 mRNA Loperamide inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA] ABCB1 protein results in increased transport of Loperamide ABCB1A protein affects the susceptibility to Loperamide |
CTD |
PMID:15502009 PMID:23976943 PMID:34719826 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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|
G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
affects response to substance |
ISO |
ABCB1B protein affects the susceptibility to Loperamide |
CTD |
PMID:15502009 |
|
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases expression |
ISO |
Loperamide results in decreased expression of ABCC2 mRNA |
CTD |
PMID:35926757 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcg5 |
ATP binding cassette subfamily G member 5 |
decreases expression |
ISO |
Loperamide results in decreased expression of ABCG5 mRNA |
CTD |
PMID:35926757 |
|
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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G |
Ano1 |
anoctamin 1 |
decreases expression multiple interactions |
ISO |
Loperamide results in decreased expression of ANO1 mRNA; Loperamide results in decreased expression of ANO1 protein Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 protein] |
CTD |
PMID:37375548 |
|
NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
Loperamide promotes the reaction [Doxorubicin results in decreased expression of BCL2 mRNA] Loperamide results in decreased expression of BCL2 mRNA |
CTD |
PMID:34719826 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G |
Cat |
catalase |
decreases expression |
EXP |
Loperamide results in decreased expression of CAT protein |
CTD |
PMID:30597669 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
ISO |
Loperamide results in increased expression of CDKN1A mRNA Loperamide promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA] |
CTD |
PMID:34719826 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Ces2h |
carboxylesterase 2H |
decreases activity multiple interactions |
ISO |
Loperamide results in decreased activity of CES2 protein [Loperamide results in decreased activity of CES2 protein] which results in increased susceptibility to Bisphenol A-Glycidyl Methacrylate |
CTD |
PMID:15687373 PMID:21951919 PMID:28647665 |
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NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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G |
Ch25h |
cholesterol 25-hydroxylase |
increases expression |
ISO |
Loperamide results in increased expression of CH25H mRNA |
CTD |
PMID:35926757 |
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NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195
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G |
Ckb |
creatine kinase B |
multiple interactions |
EXP |
Loperamide results in increased secretion of [CKM protein binds to CKB protein] |
CTD |
PMID:30597669 |
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NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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G |
Ckm |
creatine kinase, M-type |
multiple interactions |
EXP |
Loperamide results in increased secretion of [CKM protein binds to CKB protein] |
CTD |
PMID:30597669 |
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NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide |
CTD |
PMID:31299239 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases expression |
ISO |
Loperamide results in increased expression of CYP7A1 mRNA |
CTD |
PMID:35926757 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Fabp6 |
fatty acid binding protein 6 |
increases expression |
ISO |
Loperamide results in increased expression of FABP6 mRNA |
CTD |
PMID:35926757 |
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NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282
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Fdps |
farnesyl diphosphate synthase |
increases expression |
ISO |
Loperamide results in increased expression of FDPS mRNA |
CTD |
PMID:35926757 |
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NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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Got1 |
glutamic-oxaloacetic transaminase 1 |
increases secretion |
EXP |
Loperamide results in increased secretion of GOT1 protein |
CTD |
PMID:30597669 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression |
ISO |
Loperamide results in increased expression of HMGCR mRNA |
CTD |
PMID:35926757 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Htr4 |
5-hydroxytryptamine receptor 4 |
multiple interactions decreases expression |
ISO |
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA] |
CTD |
PMID:37375548 |
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NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321
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G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
increases expression |
ISO |
Loperamide results in increased expression of IDI1 mRNA |
CTD |
PMID:35926757 |
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NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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G |
Il2 |
interleukin 2 |
decreases expression |
ISO |
Loperamide results in decreased expression of IL2 mRNA |
CTD |
PMID:23965172 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il4 |
interleukin 4 |
increases expression |
ISO |
Loperamide results in increased expression of IL4 mRNA |
CTD |
PMID:23965172 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Lss |
lanosterol synthase |
increases expression |
ISO |
Loperamide results in increased expression of LSS mRNA |
CTD |
PMID:35926757 |
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NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
Loperamide results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:23965172 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
Loperamide results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:23965172 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
decreases expression multiple interactions |
ISO |
Loperamide results in decreased expression of MAPK8 mRNA Loperamide promotes the reaction [Doxorubicin results in decreased expression of MAPK8 mRNA] |
CTD |
PMID:34719826 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases expression |
ISO |
Loperamide promotes the reaction [Doxorubicin results in decreased expression of MTOR mRNA] Loperamide results in decreased expression of MTOR mRNA |
CTD |
PMID:34719826 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Mvk |
mevalonate kinase |
increases expression |
ISO |
Loperamide results in increased expression of MVK mRNA |
CTD |
PMID:35926757 |
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NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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G |
Mylk |
myosin light chain kinase |
decreases expression multiple interactions |
ISO |
Loperamide results in decreased expression of MYLK mRNA Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA] |
CTD |
PMID:37375548 |
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NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression |
ISO |
Loperamide results in increased expression of NFKBIA protein |
CTD |
PMID:22258905 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions decreases expression |
ISO |
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of NOS1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of NOS1 protein] |
CTD |
PMID:37375548 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
[Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein |
CTD |
PMID:20869355 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
[Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Loperamide binds to and results in decreased activity of NR1I3 protein alternative form |
CTD |
PMID:20869355 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Oprd1 |
opioid receptor, delta 1 |
affects response to substance |
ISO |
OPRD1 protein affects the susceptibility to Loperamide |
CTD |
PMID:25261794 |
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NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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G |
Pld2 |
phospholipase D2 |
increases activity |
ISO |
Loperamide results in increased activity of PLD2 protein |
CTD |
PMID:23965172 |
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NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
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G |
Ryr3 |
ryanodine receptor 3 |
decreases expression multiple interactions |
ISO |
Loperamide results in decreased expression of RYR3 mRNA Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA] |
CTD |
PMID:37375548 |
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NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Loperamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc51a |
solute carrier family 51 member A |
increases expression |
ISO |
Loperamide results in increased expression of SLC51A mRNA |
CTD |
PMID:35926757 |
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NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
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G |
Sqle |
squalene epoxidase |
increases expression |
ISO |
Loperamide results in increased expression of SQLE mRNA |
CTD |
PMID:35926757 |
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NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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G |
Tnni3 |
troponin I3, cardiac type |
increases secretion |
EXP |
Loperamide results in increased secretion of TNNI3 protein |
CTD |
PMID:30597669 |
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NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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G |
Trpm7 |
transient receptor potential cation channel, subfamily M, member 7 |
multiple interactions decreases expression |
ISO |
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of TRPM7 protein] |
CTD |
PMID:37375548 |
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NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression affects activity |
ISO |
Methadone results in increased expression of ABCB1 protein Methadone affects the activity of ABCB1 protein |
CTD |
PMID:19840843 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
affects activity increases expression |
EXP |
Methadone affects the activity of ABCB1B protein Methadone results in increased expression of ABCB1B protein |
CTD |
PMID:19840843 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Bax |
BCL2 associated X, apoptosis regulator |
affects localization |
ISO |
Methadone affects the localization of BAX protein |
CTD |
PMID:20691259 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases secretion |
EXP |
Methadone results in increased secretion of CCL2 protein |
CTD |
PMID:20178837 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases secretion |
EXP |
Methadone results in increased secretion of CCL3 protein |
CTD |
PMID:20178837 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
increases secretion |
EXP |
Methadone results in increased secretion of CX3CL1 protein |
CTD |
PMID:20178837 |
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NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases secretion |
EXP |
Methadone results in increased secretion of CXCL1 protein |
CTD |
PMID:20178837 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cycs |
cytochrome c, somatic |
affects localization |
ISO |
Methadone affects the localization of CYCS protein |
CTD |
PMID:20691259 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
multiple interactions affects metabolic processing |
ISO |
Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone] |
CTD |
PMID:15242824 |
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NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
increases metabolic processing decreases activity |
ISO |
CYP2D22 protein results in increased metabolism of Methadone Methadone results in decreased activity of CYP2D6 protein |
CTD |
PMID:16595712 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
affects metabolic processing increases metabolic processing |
ISO |
CYP3A4 protein affects the metabolism of Methadone CYP3A4 protein results in increased metabolism of Methadone |
CTD |
PMID:15986265 PMID:16595712 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP |
Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA] |
CTD |
PMID:18990547 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Hcrt |
hypocretin neuropeptide precursor |
multiple interactions |
EXP |
Methadone affects the reaction [Cocaine affects the expression of HCRT mRNA] |
CTD |
PMID:18990547 |
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NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210
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G |
Il10 |
interleukin 10 |
increases secretion |
EXP |
Methadone results in increased secretion of IL10 protein |
CTD |
PMID:20178837 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1a |
interleukin 1 alpha |
increases expression |
EXP |
Methadone results in increased expression of IL1A protein |
CTD |
PMID:20178837 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
increases secretion increases expression |
EXP |
Methadone results in increased secretion of IL1B protein Methadone results in increased expression of IL1B protein |
CTD |
PMID:20178837 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
decreases expression |
ISO |
Methadone results in decreased expression of IL2 mRNA |
CTD |
PMID:23965172 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il4 |
interleukin 4 |
increases expression multiple interactions |
ISO |
Methadone results in increased expression of IL4 mRNA; Methadone results in increased expression of IL4 protein CTAP octapeptide inhibits the reaction [Methadone results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Methadone results in increased expression of IL4 mRNA] |
CTD |
PMID:23965172 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
increases expression increases secretion |
EXP |
Methadone results in increased expression of IL6 mRNA; Methadone results in increased expression of IL6 protein Methadone results in increased secretion of IL6 protein |
CTD |
PMID:20178837 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins2 |
insulin 2 |
decreases response to substance |
ISO |
Methadone results in decreased susceptibility to INS protein |
CTD |
PMID:2554359 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions decreases activity |
ISO |
Chlorobutanol promotes the reaction [Methadone results in decreased activity of KCNH2 protein] |
CTD |
PMID:14527710 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Lep |
leptin |
increases expression |
ISO |
Methadone results in increased expression of LEP protein |
CTD |
PMID:15717844 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation |
ISO |
Methadone results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:23965172 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation |
ISO |
Methadone results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:23965172 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression |
ISO |
Methadone results in increased expression of NFKBIA protein |
CTD |
PMID:22258905 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Oprd1 |
opioid receptor, delta 1 |
affects binding multiple interactions |
EXP |
Methadone binds to OPRD1 protein [Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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G |
Oprk1 |
opioid receptor, kappa 1 |
affects binding multiple interactions |
EXP |
Methadone binds to OPRK1 protein [Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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G |
Oprm1 |
opioid receptor, mu 1 |
multiple interactions affects binding |
EXP |
[Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin |
CTD |
PMID:7562497 |
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NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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G |
Pld2 |
phospholipase D2 |
increases activity |
ISO |
Methadone results in increased activity of PLD2 protein |
CTD |
PMID:23965172 |
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NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
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G |
Prl |
prolactin |
affects secretion increases secretion increases expression |
ISO |
Methadone affects the secretion of PRL protein Methadone results in increased secretion of PRL protein Methadone results in increased expression of PRL protein |
CTD |
PMID:2554359 PMID:16675813 PMID:21094671 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Tlr4 |
toll-like receptor 4 |
affects binding increases expression affects response to substance multiple interactions |
ISO EXP |
Methadone binds to TLR4 protein Methadone results in increased expression of TLR4 mRNA; Methadone results in increased expression of TLR4 protein Methadone affects the susceptibility to TLR4 protein Naloxone affects the reaction [Methadone binds to TLR4 protein] |
CTD |
PMID:20178837 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
increases secretion increases expression |
EXP |
Methadone results in increased secretion of TNF protein Methadone results in increased expression of TNF protein |
CTD |
PMID:20178837 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
affects metabolic processing multiple interactions |
ISO EXP |
ABCB1 affects the metabolism of Morphine [Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA |
CTD |
PMID:23748253 PMID:26554626 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions |
EXP |
[Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA |
CTD |
PMID:26554626 |
|
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Abtb3 |
ankyrin repeat and BTB domain containing 3 |
decreases expression |
ISO |
Morphine results in decreased expression of ABTB3 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834
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G |
Acat1 |
acetyl-CoA acetyltransferase 1 |
decreases expression multiple interactions |
EXP |
Morphine results in decreased expression of ACAT1 protein Morphine deficiency affects the reaction [Morphine results in decreased expression of ACAT1 protein] |
CTD |
PMID:23056601 |
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NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
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Ache |
acetylcholinesterase |
multiple interactions increases chemical synthesis |
ISO |
[ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine ACHE protein results in increased chemical synthesis of Morphine |
CTD |
PMID:30080993 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Adcy1 |
adenylate cyclase 1 |
multiple interactions |
ISO |
[ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine |
CTD |
PMID:16914643 |
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NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
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G |
Adcy6 |
adenylate cyclase 6 |
affects expression |
EXP |
Morphine affects the expression of ADCY6 mRNA |
CTD |
PMID:15829634 |
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NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
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G |
Adcy8 |
adenylate cyclase 8 |
affects response to substance affects expression multiple interactions |
ISO EXP |
ADCY8 protein affects the susceptibility to Morphine Morphine affects the expression of ADCY8 mRNA [ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine |
CTD |
PMID:15829634 PMID:16914643 |
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NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911
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Adgra1 |
adhesion G protein-coupled receptor A1 |
decreases expression |
ISO |
Morphine results in decreased expression of ADGRA1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 1:194,629,744...194,673,254
Ensembl chr 1:194,629,726...194,672,550
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G |
Adora1 |
adenosine A1 receptor |
affects response to substance increases expression multiple interactions |
ISO EXP |
ADORA1 protein affects the susceptibility to Morphine Morphine results in increased expression of ADORA1 mRNA; Morphine results in increased expression of ADORA1 protein [lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA; [lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein |
CTD |
PMID:9407998 PMID:26478469 |
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NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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G |
Adora2a |
adenosine A2a receptor |
affects response to substance increases expression |
ISO |
ADORA2A protein affects the susceptibility to Morphine Morphine results in increased expression of ADORA2A mRNA |
CTD |
PMID:14756803 PMID:21955143 |
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NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Adra2a |
adrenoceptor alpha 2A |
increases expression |
EXP |
morphine increases expression of Adra2a mRNA in cerebral cortex |
RGD |
PMID:9105684 |
RGD:401976538 |
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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G |
Agrp |
agouti related neuropeptide |
increases expression |
ISO |
Morphine results in increased expression of AGRP mRNA |
CTD |
PMID:20144693 |
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NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
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G |
Aif1 |
allograft inflammatory factor 1 |
multiple interactions increases expression |
EXP ISO |
[lead acetate co-treated with Morphine] results in increased expression of AIF1 mRNA corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of AIF1 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]] |
CTD |
PMID:26478469 PMID:37394652 |
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NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Ak5 |
adenylate kinase 5 |
decreases expression |
ISO |
Morphine results in decreased expression of AK5 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
decreases expression |
EXP |
Morphine results in decreased expression of AKR1B1 protein |
CTD |
PMID:23056601 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases expression decreases expression |
ISO |
ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form] Morphine results in increased expression of AKT1 protein modified form Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form] |
CTD |
PMID:19239323 PMID:20600172 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb |
albumin |
multiple interactions decreases expression |
EXP |
Morphine deficiency inhibits the reaction [Morphine results in decreased expression of ALB protein] |
CTD |
PMID:23056601 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Ano3 |
anoctamin 3 |
increases expression |
ISO |
Morphine results in increased expression of ANO3 mRNA |
CTD |
PMID:21955143 |
|
NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154
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G |
Anxa6 |
annexin A6 |
decreases expression |
EXP |
Morphine results in decreased expression of ANXA6 protein |
CTD |
PMID:23056601 |
|
NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433
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G |
Apoa1 |
apolipoprotein A1 |
increases expression |
EXP |
Morphine results in increased expression of APOA1 protein |
CTD |
PMID:23056601 |
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NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apob |
apolipoprotein B |
increases expression |
ISO |
Morphine results in increased expression of APOB protein |
CTD |
PMID:18980684 |
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NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
Apoe |
apolipoprotein E |
increases expression multiple interactions |
EXP |
Morphine results in increased expression of APOE protein Morphine deficiency affects the reaction [Morphine results in increased expression of APOE protein] |
CTD |
PMID:23056601 |
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NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
Aqp1 |
aquaporin 1 |
increases expression |
ISO |
Morphine results in increased expression of AQP1 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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G |
Aqp3 |
aquaporin 3 (Gill blood group) |
increases expression |
EXP |
Morphine results in increased expression of AQP3 mRNA; Morphine results in increased expression of AQP3 protein |
CTD |
PMID:25766885 |
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NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
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G |
Aqp4 |
aquaporin 4 |
decreases expression |
ISO |
Morphine results in decreased expression of AQP4 mRNA |
CTD |
PMID:21955143 |
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NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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G |
Arc |
activity-regulated cytoskeleton-associated protein |
increases expression |
EXP IEP |
morphine increases expression in Arc protein in nucleus accumbens morphine increases expression of Arc mRNA in prefrontal cortex morphine co-treated with naloxone increases expression of Arc protein in brain Morphine increases expression of Arc protein in shell of nucleus accumbens |
RGD |
PMID:21549764 PMID:30550948 PMID:19262551 PMID:25746394 |
RGD:401851922, RGD:401959617, RGD:401938601, RGD:11087075 |
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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Arl4d |
ARF like GTPase 4D |
increases expression |
ISO |
Morphine results in increased expression of ARL4D mRNA |
CTD |
PMID:20144693 |
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NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836
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G |
Arl6ip5 |
ARF like GTPase 6 interacting protein 5 |
multiple interactions increases expression |
ISO EXP |
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein] Morphine results in increased expression of ARL6IP5 protein ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein] |
CTD |
PMID:21600884 |
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NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
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G |
Arpp21 |
cAMP regulated phosphoprotein 21 |
increases expression decreases expression |
ISO |
Morphine results in increased expression of ARPP21 mRNA Morphine deficiency results in decreased expression of ARPP21 mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297
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G |
Arrb2 |
arrestin, beta 2 |
affects response to substance multiple interactions |
ISO EXP |
ARRB2 gene SNP affects the susceptibility to Morphine [Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein ARRB2 protein affects the susceptibility to Morphine [gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form] |
CTD |
PMID:16103897 PMID:19239323 PMID:19477204 PMID:23300227 PMID:24063433 PMID:35477798 More...
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NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
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G |
Art3 |
ADP-ribosyltransferase 3 |
multiple interactions increases expression |
EXP |
Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein] |
CTD |
PMID:23056601 |
|
NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407
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G |
Asic4 |
acid sensing ion channel subunit family member 4 |
increases expression |
ISO |
Morphine results in increased expression of ASIC4 mRNA |
CTD |
PMID:21178816 |
|
NCBI chr 9:76,941,532...76,962,900
Ensembl chr 9:76,941,532...76,962,900
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO |
corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]] |
CTD |
PMID:37394652 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atic |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
decreases expression |
EXP |
Morphine results in decreased expression of ATIC protein |
CTD |
PMID:23056601 |
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NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889
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G |
Atrx |
ATRX, chromatin remodeler |
increases expression |
ISO |
Morphine results in increased expression of ATRX mRNA |
CTD |
PMID:21955143 |
|
NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330
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G |
Avp |
arginine vasopressin |
increases expression |
ISO |
Morphine increases expression of Avp mRNA in the dorsal striatum |
RGD |
PMID:29772497 |
RGD:408418735 |
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
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G |
Avpr1a |
arginine vasopressin receptor 1A |
decreases expression |
ISO |
Morphine results in decreased expression of AVPR1A mRNA |
CTD |
PMID:21178816 |
|
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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G |
Bag3 |
BAG cochaperone 3 |
increases expression |
EXP |
Morphine results in increased expression of BAG3 protein |
CTD |
PMID:23056601 |
|
NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
Morphine results in increased expression of BAK1 protein |
CTD |
PMID:19070643 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression decreases expression |
ISO EXP |
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Morphine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein] Morphine results in increased expression of BAX mRNA; Morphine results in increased expression of BAX protein Morphine results in decreased expression of BAX mRNA epigallocatechin gallate inhibits the reaction [Morphine results in increased expression of BAX protein]; Lithium inhibits the reaction [Morphine results in increased expression of BAX mRNA] TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein] |
CTD |
PMID:10534122 PMID:10809959 PMID:12196588 PMID:12702572 PMID:12927789 PMID:15183518 PMID:17542780 PMID:18976035 PMID:19070643 PMID:21483469 PMID:32129083 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
Morphine results in increased expression of BBC3 mRNA |
CTD |
PMID:19397953 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcas1 |
brain enriched myelin associated protein 1 |
decreases expression |
ISO |
Morphine results in decreased expression of BCAS1 mRNA |
CTD |
PMID:21955143 |
|
NCBI chr 3:159,136,077...159,219,072
Ensembl chr 3:159,136,083...159,219,106
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G |
Bche |
butyrylcholinesterase |
increases chemical synthesis multiple interactions |
ISO |
BCHE protein results in increased chemical synthesis of Morphine [BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine |
CTD |
PMID:30080993 |
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NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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G |
Bcl11b |
BCL11 transcription factor B |
increases expression decreases expression |
ISO |
Morphine results in increased expression of BCL11B mRNA Morphine deficiency results in decreased expression of BCL11B mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO EXP |
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]; PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein] Morphine results in decreased expression of BCL2 mRNA; Morphine results in decreased expression of BCL2 protein epigallocatechin gallate inhibits the reaction [Morphine results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA] |
CTD |
PMID:10534122 PMID:12196588 PMID:12927789 PMID:17542780 PMID:18976035 PMID:19292871 PMID:20190558 PMID:21483469 PMID:32129083 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
EXP |
Morphine results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:15183518 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
Morphine results in increased expression of BCL2L11 protein |
CTD |
PMID:19292871 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bdnf |
brain-derived neurotrophic factor |
increases expression increases expression decreases expression multiple interactions |
ISO EXP |
Morphine results in increased expression of BDNF mRNA; Morphine results in increased expression of BDNF protein Morphine increases expression of Bdnf mRNA in ventral tegmental area Morphine results in decreased expression of BDNF mRNA; Morphine results in decreased expression of BDNF mRNA alternative form Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]; Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]; Morphine promotes the reaction [ING2 protein binds to BDNF promoter]; Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]; Morphine promotes the reaction [SIN3A protein binds to BDNF promoter]; Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter] AM 251 inhibits the reaction [Morphine results in increased expression of BDNF protein]; BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA] |
CTD RGD |
PMID:19033880 PMID:25643298 PMID:27461790 PMID:30550948 |
RGD:401959617 |
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Becn1 |
beclin 1 |
multiple interactions increases expression |
ISO |
Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein] Morphine results in increased expression of BECN1 protein |
CTD |
PMID:20190558 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bex4 |
brain expressed, X-linked 4 |
increases expression |
ISO |
Morphine results in increased expression of BEX4 mRNA |
CTD |
PMID:21178816 |
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NCBI chr X:99,131,985...99,133,417
Ensembl chr X:99,131,942...99,133,531
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G |
Bok |
BCL2 family apoptosis regulator BOK |
decreases expression |
ISO |
Morphine results in decreased expression of BOK mRNA |
CTD |
PMID:21955143 |
|
NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
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G |
C1ql3 |
complement C1q like 3 |
increases expression |
ISO |
Morphine results in increased expression of C1QL3 mRNA |
CTD |
PMID:21178816 |
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NCBI chr17:76,119,344...76,129,170
Ensembl chr17:76,119,447...76,128,530
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G |
Calb1 |
calbindin 1 |
increases expression |
ISO |
Morphine results in increased expression of CALB1 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
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G |
Calca |
calcitonin-related polypeptide alpha |
increases expression multiple interactions |
EXP ISO |
Morphine results in increased expression of CALCA mRNA; Morphine results in increased expression of CALCA protein PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein] GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein] |
CTD |
PMID:16935424 PMID:20359526 PMID:20568289 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
affects response to substance increases expression |
ISO |
CAMK2A protein affects the susceptibility to Morphine Morphine results in increased expression of CAMK2A mRNA |
CTD |
PMID:20053885 PMID:21955143 |
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NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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G |
Cap1 |
cyclase associated actin cytoskeleton regulatory protein 1 |
decreases expression |
ISO |
Morphine results in decreased expression of CAP1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769
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G |
Car2 |
carbonic anhydrase 2 |
increases expression |
ISO |
Morphine results in increased expression of CAR2 mRNA |
CTD |
PMID:20144693 |
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NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Carhsp1 |
calcium regulated heat stable protein 1 |
increases expression |
ISO |
Morphine results in increased expression of CARHSP1 mRNA |
CTD |
PMID:21178816 |
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NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019
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G |
Cartpt |
CART prepropeptide |
increases expression |
ISO |
Morphine results in increased expression of CARTPT mRNA |
CTD |
PMID:20144693 |
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NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
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G |
Casp1 |
caspase 1 |
decreases expression |
EXP |
Morphine results in decreased expression of CASP1 mRNA |
CTD |
PMID:15183518 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage increases activity increases expression |
ISO EXP |
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Morphine results in increased activity of and results in increased cleavage of CASP3 protein; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein] Morphine results in increased cleavage of CASP3 protein Morphine results in increased expression of CASP3 protein epigallocatechin gallate inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein] corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form]; SB 203580 inhibits the reaction [Morphine results in increased activity of CASP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]] Morphine results in increased expression of CASP3 protein; Morphine results in increased expression of CASP3 protein alternative form |
CTD |
PMID:10534122 PMID:11590188 PMID:12196588 PMID:16102899 PMID:17542780 PMID:18756534 PMID:18832014 PMID:19070643 PMID:19292871 PMID:20600172 PMID:20711699 PMID:21483469 PMID:32129083 PMID:37394652 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8 |
caspase 8 |
multiple interactions increases activity decreases expression |
ISO |
ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form] Morphine results in increased activity of CASP8 protein |
CTD |
PMID:11590188 PMID:19070643 PMID:19239323 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9 |
caspase 9 |
increases activity increases expression |
ISO EXP |
Morphine results in increased activity of CASP9 protein Morphine results in increased expression of CASP9 mRNA |
CTD |
PMID:15183518 PMID:19292871 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat |
catalase |
multiple interactions |
ISO |
CAT protein inhibits the reaction [Morphine results in increased abundance of Hydrogen Peroxide] |
CTD |
PMID:14871405 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cbln1 |
cerebellin 1 precursor |
decreases expression |
ISO |
Morphine results in decreased expression of CBLN1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572
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Ccdc136 |
coiled-coil domain containing 136 |
decreases expression |
ISO |
Morphine results in decreased expression of CCDC136 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 4:57,997,825...58,027,598
Ensembl chr 4:57,997,853...58,027,646
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Cck |
cholecystokinin |
decreases expression |
ISO |
Morphine results in decreased expression of CCK mRNA |
CTD |
PMID:21955143 |
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NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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Cckbr |
cholecystokinin B receptor |
affects response to substance |
ISO |
CCKBR protein affects the susceptibility to Morphine |
CTD |
PMID:11403953 PMID:11880531 |
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NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
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Ccl2 |
C-C motif chemokine ligand 2 |
increases secretion |
EXP |
Morphine results in increased secretion of CCL2 protein |
CTD |
PMID:20178837 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl3 |
C-C motif chemokine ligand 3 |
increases secretion |
EXP |
Morphine results in increased secretion of CCL3 protein |
CTD |
PMID:20178837 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions decreases expression |
ISO |
beta-funaltrexamine inhibits the reaction [Morphine results in decreased expression of CCL5 protein]; Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] |
CTD |
PMID:11106302 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Cd38 |
CD38 molecule |
affects response to substance |
ISO |
CD38 affects the susceptibility to Morphine |
CTD |
PMID:20551293 |
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NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
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Cd79b |
CD79b molecule |
increases expression |
ISO |
Morphine results in increased expression of CD79B mRNA |
CTD |
PMID:20144693 |
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NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625
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Cd9 |
CD9 molecule |
increases expression |
EXP |
Morphine results in increased expression of CD9 protein |
CTD |
PMID:23056601 |
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NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
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Cdh22 |
cadherin 22 |
increases expression |
ISO |
Morphine results in increased expression of CDH22 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein |
CTD |
PMID:12702572 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cep83 |
centrosomal protein 83 |
increases expression |
ISO |
Morphine results in increased expression of CEP83 mRNA |
CTD |
PMID:20144693 |
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NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:29,280,419...29,389,574
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Ces2h |
carboxylesterase 2H |
increases chemical synthesis multiple interactions |
ISO |
CES2 protein results in increased chemical synthesis of Morphine Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine] |
CTD |
PMID:8930175 |
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NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Chrm5 |
cholinergic receptor, muscarinic 5 |
affects response to substance |
ISO |
CHRM5 protein affects the susceptibility to Morphine |
CTD |
PMID:12154229 |
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NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
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Cirbp |
cold inducible RNA binding protein |
increases expression |
ISO |
Morphine results in increased expression of CIRBP mRNA |
CTD |
PMID:21955143 |
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NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
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Cldn2 |
claudin 2 |
increases expression |
ISO |
Morphine results in increased expression of CLDN2 mRNA |
CTD |
PMID:21178816 |
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NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
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Cmbl |
carboxymethylenebutenolidase homolog |
decreases expression |
EXP |
Morphine results in decreased expression of CMBL protein |
CTD |
PMID:23056601 |
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NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
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Cmtm5 |
CKLF-like MARVEL transmembrane domain containing 5 |
increases expression |
ISO |
Morphine results in increased expression of CMTM5 mRNA |
CTD |
PMID:21955143 |
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NCBI chr15:28,412,624...28,415,304
Ensembl chr15:28,412,624...28,415,287
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G |
Cnbp |
CCHC-type zinc finger, nucleic acid binding protein |
multiple interactions decreases expression |
EXP |
Morphine deficiency affects the reaction [Morphine results in decreased expression of CNBP protein] |
CTD |
PMID:23056601 |
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NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637
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Cnr1 |
cannabinoid receptor 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
[Morphine results in increased expression of CNR1 mRNA] which results in increased susceptibility to Dronabinol; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA] Morphine deficiency results in decreased expression of CNR1 mRNA CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA] |
CTD |
PMID:9351646 PMID:21955143 PMID:22258905 PMID:27126842 |
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NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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Comt |
catechol-O-methyltransferase |
affects response to substance multiple interactions |
ISO |
COMT protein affects the susceptibility to Morphine [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine |
CTD |
PMID:18834357 PMID:21127283 |
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NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Coq9 |
coenzyme Q9 |
decreases expression |
EXP |
Morphine results in decreased expression of COQ9 protein |
CTD |
PMID:23056601 |
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NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949
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Cpe |
carboxypeptidase E |
increases expression |
ISO |
Morphine results in increased expression of CPE mRNA |
CTD |
PMID:20144693 |
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NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
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Creb1 |
cAMP responsive element binding protein 1 |
decreases expression decreases phosphorylation increases phosphorylation multiple interactions increases expression |
EXP ISO |
Morphine results in decreased expression of CREB1 mRNA morphine decreases phosphorylation of Creb1 protein in prefrontal cortex morphine increases phosphorylation of Creb protein in Cortical cell AM 251 inhibits the reaction [Morphine results in increased phosphorylation of CREB1 protein]; suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein] Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter] Morphine results in decreased phosphorylation of CREB1 protein |
CTD RGD |
PMID:14750654 PMID:15183518 PMID:16598705 PMID:23292329 PMID:25643298 PMID:27461790 PMID:33609567 PMID:19324071 PMID:30632088 More...
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RGD:401901600, RGD:401901284 |
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Crem |
cAMP responsive element modulator |
increases expression |
ISO |
Morphine results in increased expression of CREM mRNA |
CTD |
PMID:22454534 |
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NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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Crh |
corticotropin releasing hormone |
increases expression |
ISO |
Morphine deficiency results in increased expression of CRH mRNA; Morphine results in increased expression of CRH mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Crhr1 |
corticotropin releasing hormone receptor 1 |
multiple interactions |
EXP ISO |
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Morphine deficiency CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein] |
CTD |
PMID:24398105 PMID:25582704 |
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NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
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Crp |
C-reactive protein |
increases expression |
ISO |
Morphine results in increased expression of CRP protein |
CTD |
PMID:18980684 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Cryab |
crystallin, alpha B |
decreases expression increases expression |
ISO EXP |
Morphine results in decreased expression of CRYAB mRNA Morphine results in increased expression of CRYAB protein |
CTD |
PMID:21955143 PMID:23056601 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Csdc2 |
cold shock domain containing C2 |
decreases expression |
ISO |
Morphine results in decreased expression of CSDC2 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:113,451,998...113,466,463
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Cstb |
cystatin B |
decreases expression |
EXP |
Morphine results in decreased expression of CSTB protein |
CTD |
PMID:23056601 |
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NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
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G |
Ctnnal1 |
catenin alpha-like 1 |
increases expression |
ISO |
Morphine results in increased expression of CTNNAL1 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431
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Ctsb |
cathepsin B |
increases expression |
EXP |
Morphine results in increased expression of CTSB mRNA |
CTD |
PMID:9429908 |
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Cux2 |
cut-like homeobox 2 |
increases expression |
ISO |
Morphine results in increased expression of CUX2 mRNA |
CTD |
PMID:21178816 |
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NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
affects response to substance increases secretion |
EXP |
CX3CL1 protein affects the susceptibility to Morphine Morphine results in increased secretion of CX3CL1 protein |
CTD |
PMID:15317861 PMID:20178837 |
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NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases secretion |
EXP |
Morphine results in increased secretion of CXCL1 protein |
CTD |
PMID:20178837 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxxc1 |
CXXC finger protein 1 |
affects expression |
ISO |
Morphine affects the expression of CXXC1 mRNA |
CTD |
PMID:33891991 |
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NCBI chr18:67,813,185...67,818,556
Ensembl chr18:67,813,206...67,818,551
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Cybb |
cytochrome b-245 beta chain |
increases expression multiple interactions |
ISO |
Morphine results in increased expression of CYBB protein Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein] |
CTD |
PMID:14871405 |
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NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Cycs |
cytochrome c, somatic |
increases secretion decreases secretion multiple interactions |
ISO EXP |
Morphine results in increased secretion of CYCS protein Morphine results in decreased secretion of CYCS protein Morphine inhibits the reaction [Doxorubicin affects the localization of CYCS protein] |
CTD |
PMID:15345483 PMID:17542780 PMID:19292871 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
Morphine results in decreased activity of CYP1A2 protein |
CTD |
PMID:35914676 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
increases expression |
ISO |
Morphine results in increased expression of CYP27A1 mRNA |
CTD |
PMID:20144693 |
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NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases activity |
ISO |
Morphine results in increased activity of CYP2B6 protein |
CTD |
PMID:35914676 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
affects chemical synthesis increases activity multiple interactions |
ISO |
CYP2D6 protein affects the chemical synthesis of Morphine Morphine results in increased activity of CYP2D6 protein [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine |
CTD |
PMID:15625333 PMID:16595712 PMID:21241245 PMID:35914676 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Dbi |
diazepam binding inhibitor |
increases expression |
EXP |
morphine increases expression of Dbi mRNA in brain |
RGD |
PMID:15950760 |
RGD:408361840 |
NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
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Dcxr |
dicarbonyl and L-xylulose reductase |
multiple interactions decreases expression |
EXP |
Morphine deficiency affects the reaction [Morphine results in decreased expression of DCXR protein] |
CTD |
PMID:23056601 |
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NCBI chr10:106,006,404...106,008,293
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Ddah2 |
DDAH family member 2, ADMA-independent |
multiple interactions increases expression |
EXP |
Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein] |
CTD |
PMID:23056601 |
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NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
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G |
Ddb2 |
damage specific DNA binding protein 2 |
increases expression multiple interactions |
ISO |
Morphine results in increased expression of DDB2 mRNA Naloxone inhibits the reaction [Morphine results in increased expression of DDB2] |
CTD |
PMID:19397953 |
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NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]] |
CTD |
PMID:37394652 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression |
ISO |
Morphine results in decreased expression of DHCR24 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhrs7b |
dehydrogenase/reductase 7B |
increases expression |
ISO |
Morphine results in increased expression of DHRS7B mRNA |
CTD |
PMID:21178816 |
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NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
decreases expression multiple interactions increases expression |
EXP ISO |
Morphine results in decreased expression of DLG4 mRNA; Morphine results in decreased expression of DLG4 protein Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]] Morphine results in increased expression of DLG4 mRNA |
CTD |
PMID:15183518 PMID:16598705 PMID:21955143 PMID:22713680 |
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NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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G |
Dlx5 |
distal-less homeobox 5 |
increases expression |
ISO |
Morphine results in increased expression of DLX5 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:34,999,139...35,003,407
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G |
Dnah3 |
dynein, axonemal, heavy chain 3 |
decreases expression |
ISO |
Morphine results in decreased expression of DNAH3 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 1:174,305,929...174,479,490
Ensembl chr 1:174,306,644...174,479,474
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G |
Dnmt1 |
DNA methyltransferase 1 |
increases expression |
ISO |
Morphine results in increased expression of DNMT1 mRNA |
CTD |
PMID:33891991 |
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NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
affects expression |
ISO |
Morphine affects the expression of DNMT3A mRNA |
CTD |
PMID:33891991 |
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NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
affects expression |
ISO |
Morphine affects the expression of DNMT3B mRNA |
CTD |
PMID:33891991 |
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NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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G |
Dock10 |
dedicator of cytokinesis 10 |
increases expression |
ISO |
Morphine results in increased expression of DOCK10 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525
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G |
Dpysl2 |
dihydropyrimidinase-like 2 |
multiple interactions decreases expression |
EXP |
Morphine deficiency affects the reaction [Morphine results in decreased expression of DPYSL2 protein] |
CTD |
PMID:23056601 |
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NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
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G |
Dpysl3 |
dihydropyrimidinase-like 3 |
multiple interactions decreases expression |
EXP |
Morphine deficiency promotes the reaction [Morphine results in decreased expression of DPYSL3 protein] |
CTD |
PMID:23056601 |
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NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
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G |
Drd1 |
dopamine receptor D1 |
increases expression decreases expression |
ISO |
Morphine results in increased expression of DRD1 mRNA Morphine deficiency results in decreased expression of DRD1 mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
decreases expression multiple interactions affects response to substance increases expression |
EXP ISO |
Morphine results in decreased expression of DRD2 mRNA Morphine deficiency results in decreased expression of DRD2 mRNA [lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA; [lead acetate co-treated with Morphine] results in increased expression of DRD2 protein DRD2 protein affects the susceptibility to Morphine Morphine results in increased expression of DRD2 mRNA |
CTD |
PMID:2571179 PMID:15183518 PMID:17063042 PMID:23702354 PMID:27126842 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Drd4 |
dopamine receptor D4 |
increases expression |
EXP |
Morphine results in increased expression of DRD4 mRNA |
CTD |
PMID:15183518 |
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NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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G |
Dscaml1 |
DS cell adhesion molecule-like 1 |
increases expression |
ISO |
Morphine results in increased expression of DSCAML1 mRNA |
CTD |
PMID:20144693 |
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NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320
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G |
Dusp6 |
dual specificity phosphatase 6 |
increases expression |
ISO |
Morphine deficiency results in increased expression of DUSP6 mRNA; Morphine results in increased expression of DUSP6 mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
Dync1h1 |
dynein cytoplasmic 1 heavy chain 1 |
decreases expression |
ISO |
Morphine results in decreased expression of DYNC1H1 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
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G |
Ech1 |
enoyl-CoA hydratase 1 |
decreases expression |
EXP |
Morphine results in decreased expression of ECH1 protein |
CTD |
PMID:23056601 |
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NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
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G |
Eed |
embryonic ectoderm development |
increases expression |
ISO |
Morphine results in increased expression of EED mRNA |
CTD |
PMID:33891991 |
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NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974
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G |
Efhd1 |
EF-hand domain family, member D1 |
decreases expression |
ISO |
Morphine results in decreased expression of EFHD1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917
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G |
Egr1 |
early growth response 1 |
increases expression increases expression |
ISO EXP |
Morphine deficiency results in increased expression of EGR1 mRNA; Morphine results in increased expression of EGR1 mRNA Morphine increases expression of Egr1 mRNA in ventral tegmental area and prefrontal cortex |
CTD RGD |
PMID:21955143 PMID:27126842 PMID:30550948 |
RGD:401959617 |
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Egr2 |
early growth response 2 |
increases expression |
ISO |
Morphine results in increased expression of EGR2 mRNA |
CTD |
PMID:22454534 |
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NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Egr3 |
early growth response 3 |
increases expression |
ISO |
Morphine results in increased expression of EGR3 mRNA |
CTD |
PMID:21955143 |
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NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627
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G |
Egr4 |
early growth response 4 |
multiple interactions increases expression affects response to substance |
ISO EXP |
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA]; [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA EGR4 protein affects the susceptibility to Morphine |
CTD |
PMID:22454534 |
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NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
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G |
Ehd1 |
EH-domain containing 1 |
multiple interactions decreases expression |
EXP |
Morphine deficiency inhibits the reaction [Morphine results in decreased expression of EHD1 protein] |
CTD |
PMID:23056601 |
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NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212
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G |
Ehmt1 |
euchromatic histone lysine methyltransferase 1 |
affects expression |
ISO |
Morphine affects the expression of EHMT1 mRNA |
CTD |
PMID:33891991 |
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NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007
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G |
Ehmt2 |
euchromatic histone lysine methyltransferase 2 |
affects expression |
ISO |
Morphine affects the expression of EHMT2 mRNA |
CTD |
PMID:33891991 |
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NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases phosphorylation |
ISO |
corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]] |
CTD |
PMID:37394652 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif5a |
eukaryotic translation initiation factor 5A |
increases expression |
ISO |
Morphine results in increased expression of EIF5A mRNA |
CTD |
PMID:19397953 |
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NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
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G |
Elk1 |
ETS transcription factor ELK1 |
affects response to substance increases activity multiple interactions |
ISO |
ELK1 protein affects the susceptibility to Morphine Morphine results in increased activity of ELK1 protein [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA |
CTD |
PMID:22454534 |
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NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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G |
Eml2 |
EMAP like 2 |
increases expression |
EXP |
Morphine results in increased expression of EML2 protein |
CTD |
PMID:23056601 |
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NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341
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G |
Enpp3 |
ectonucleotide pyrophosphatase/phosphodiesterase 3 |
increases expression |
EXP |
Morphine results in increased expression of ENPP3 protein |
CTD |
PMID:23056601 |
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NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041
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G |
Ephx2 |
epoxide hydrolase 2 |
increases expression |
ISO |
Morphine results in increased expression of EPHX2 mRNA |
CTD |
PMID:21178816 |
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NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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G |
Erp44 |
endoplasmic reticulum protein 44 |
increases expression |
ISO |
Morphine results in increased expression of ERP44 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761
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G |
Ezh2 |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
multiple interactions affects expression |
EXP ISO |
Morphine promotes the reaction [EZH2 protein binds to BDNF promoter] Morphine affects the expression of EZH2 mRNA |
CTD |
PMID:25643298 PMID:33891991 |
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NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
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G |
F2 |
coagulation factor II, thrombin |
increases expression multiple interactions |
EXP |
Morphine results in increased expression of F2 protein Morphine deficiency affects the reaction [Morphine results in increased expression of F2 protein] |
CTD |
PMID:23056601 |
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F7 |
coagulation factor VII |
increases expression |
ISO |
Morphine results in increased expression of F7 protein |
CTD |
PMID:18980684 |
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NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
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G |
Fam107a |
family with sequence similarity 107, member A |
increases expression |
ISO |
Morphine results in increased expression of FAM107A mRNA |
CTD |
PMID:21955143 |
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NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
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G |
Fas |
Fas cell surface death receptor |
multiple interactions increases expression |
ISO |
[FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein] [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein Morphine results in increased expression of FAS mRNA |
CTD |
PMID:12702572 PMID:16210602 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions increases expression |
ISO |
[FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein] Morphine results in increased expression of FASL mRNA |
CTD |
PMID:16210602 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fblim1 |
filamin binding LIM protein 1 |
increases expression multiple interactions |
EXP |
Morphine results in increased expression of FBLIM1 protein Morphine deficiency affects the reaction [Morphine results in increased expression of FBLIM1 protein] |
CTD |
PMID:23056601 |
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NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757
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G |
Fbn1 |
fibrillin 1 |
decreases expression |
ISO |
Morphine results in decreased expression of FBN1 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
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G |
Fga |
fibrinogen alpha chain |
affects secretion |
EXP |
Morphine affects the secretion of FGA protein modified form |
CTD |
PMID:24855564 |
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NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases secretion multiple interactions |
ISO |
Morphine results in decreased secretion of FGF2 protein Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein] |
CTD |
PMID:20564181 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fgfr1 |
Fibroblast growth factor receptor 1 |
increases expression |
EXP |
Morphine results in increased expression of FGFR1 mRNA |
CTD |
PMID:15183518 |
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NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
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G |
Fh |
fumarate hydratase |
increases expression |
EXP |
Morphine results in increased expression of FH protein |
CTD |
PMID:23056601 |
|
NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
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G |
Fhl2 |
four and a half LIM domains 2 |
multiple interactions decreases expression |
EXP |
Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein] |
CTD |
PMID:23056601 |
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NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192
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G |
Fn1 |
fibronectin 1 |
increases expression |
ISO |
Morphine results in increased expression of FN1 mRNA |
CTD |
PMID:20144693 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions affects expression increases expression |
ISO EXP |
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein; [Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Plant Extracts inhibits the reaction [Morphine results in increased expression of FOS protein] Morphine deficiency affects the expression of FOS protein Morphine results in increased expression of FOS mRNA; Morphine results in increased expression of FOS protein Morphine affects the expression of FOS mRNA 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Morphine results in increased expression of FOS protein]; [Morphine co-treated with Cocaine] affects the expression of FOS; [Morphine co-treated with N-Methyl-3,4-methylenedioxyamphetamine] affects the expression of FOS; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; Genistein inhibits the reaction [Morphine results in increased expression of FOS protein]; Morphine affects the reaction [Formaldehyde results in increased expression of FOS protein]; N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide inhibits the reaction [Morphine results in increased expression of FOS protein]; Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]; SCH772984 inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; U 0126 inhibits the reaction [Morphine results in increased expression of FOS protein] |
CTD |
PMID:10521585 PMID:10814832 PMID:12821175 PMID:12934646 PMID:15183518 PMID:15196791 PMID:15196794 PMID:16935424 PMID:20727678 PMID:22258905 PMID:22590628 PMID:25308750 PMID:27126842 PMID:32319158 More...
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
EXP ISO |
Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein] morphine increases expression of Fosb protein in nucleus accumbens and caudate-putamen morphine increases expression of FosB mRNA in striatum morphine increases expression of Fosb protein in the Brainstem morphine increases expression of Fosb protein in brain Morphine results in increased expression of FOSB mRNA Morphine results in increased expression of FOSB mRNA; Morphine results in increased expression of FOSB protein; Morphine results in increased expression of FOSB protein alternative form; Morphine results in increased expression of FOSB protein modified form |
CTD RGD |
PMID:15899480 PMID:18293355 PMID:22454534 PMID:23185589 PMID:19324071 PMID:30632088 PMID:31442272 PMID:20438612 PMID:23185589 More...
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RGD:401901600, RGD:401901284, RGD:401851072, RGD:401900159, RGD:401851068 |
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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G |
Foxp1 |
forkhead box P1 |
increases expression decreases expression |
ISO |
Morphine results in increased expression of FOXP1 mRNA Morphine deficiency results in decreased expression of FOXP1 mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
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G |
Fxyd7 |
FXYD domain-containing ion transport regulator 7 |
decreases expression |
ISO |
Morphine results in decreased expression of FXYD7 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 1:86,277,678...86,286,954
Ensembl chr 1:86,277,678...86,286,954
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G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
decreases expression increases expression |
EXP |
Morphine results in decreased expression of GABRA1 mRNA Morphine results in increased expression of GABRA1 mRNA |
CTD |
PMID:15183518 |
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NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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G |
Gabra4 |
gamma-aminobutyric acid type A receptor subunit alpha 4 |
increases expression |
ISO |
Morphine results in increased expression of GABRA4 mRNA |
CTD |
PMID:21178816 |
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NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
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G |
Gabrd |
gamma-aminobutyric acid type A receptor subunit delta |
increases expression |
EXP |
Morphine results in increased expression of GABRD mRNA |
CTD |
PMID:15183518 |
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NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
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G |
Gabrg2 |
gamma-aminobutyric acid type A receptor subunit gamma 2 |
increases expression |
ISO |
Morphine results in increased expression of GABRG2 mRNA |
CTD |
PMID:21955143 |
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NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
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G |
Gad1 |
glutamate decarboxylase 1 |
increases expression |
EXP |
Morphine results in increased expression of GAD1 mRNA |
CTD |
PMID:15673448 PMID:18312583 |
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NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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G |
Gad2 |
glutamate decarboxylase 2 |
increases expression |
ISO |
Morphine results in increased expression of GAD2 mRNA |
CTD |
PMID:21178816 |
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NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
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G |
Gal |
galanin and GMAP prepropeptide |
increases expression decreases expression |
ISO |
Morphine results in increased expression of GAL mRNA Morphine results in decreased expression of GAL mRNA |
CTD |
PMID:21178816 PMID:21955143 |
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NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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G |
Galr1 |
galanin receptor 1 |
increases expression |
ISO |
morphine co-treated with naltrexone increases expression of Galr1 in locus ceruleus |
RGD |
PMID:10882839 |
RGD:407984714 |
NCBI chr18:75,772,021...75,787,577
Ensembl chr18:75,772,023...75,787,577
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
decreases expression |
EXP |
Morphine results in decreased expression of GAPDH protein |
CTD |
PMID:23056601 |
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NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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G |
Gcnt2 |
glucosaminyl (N-acetyl) transferase 2 |
increases expression decreases expression |
ISO |
Morphine results in increased expression of GCNT2 mRNA Morphine deficiency results in decreased expression of GCNT2 mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression multiple interactions |
ISO EXP |
Morphine results in decreased expression of GFAP mRNA [lead acetate co-treated with Morphine] results in increased expression of GFAP mRNA |
CTD |
PMID:21955143 PMID:26478469 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gfm1 |
G elongation factor, mitochondrial 1 |
decreases expression |
EXP |
Morphine results in decreased expression of GFM1 protein |
CTD |
PMID:23056601 |
|
NCBI chr 2:151,700,573...151,745,477
Ensembl chr 2:151,700,564...151,745,471
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G |
Gh1 |
growth hormone 1 |
decreases expression increases secretion |
ISO EXP |
Morphine results in decreased expression of GH mRNA Morphine results in increased secretion of GH1 protein |
CTD |
PMID:7201058 PMID:21178816 |
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NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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G |
Gjc2 |
gap junction protein, gamma 2 |
decreases expression |
ISO |
Morphine results in decreased expression of GJC2 mRNA |
CTD |
PMID:21955143 |
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NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467
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G |
Glra2 |
glycine receptor, alpha 2 |
increases expression |
ISO |
Morphine results in increased expression of GLRA2 mRNA |
CTD |
PMID:21178816 |
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NCBI chr X:29,020,377...29,241,666
Ensembl chr X:29,020,557...29,241,666
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G |
Gnai2 |
G protein subunit alpha i2 |
decreases expression multiple interactions increases expression |
EXP ISO |
Morphine results in decreased expression of GNAI2 mRNA Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein] Morphine results in increased expression of GNAI2 mRNA |
CTD |
PMID:15183518 PMID:18652891 |
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NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
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G |
Gnas |
GNAS complex locus |
increases expression |
EXP |
Morphine results in increased expression of GNAS mRNA; Morphine results in increased expression of GNAS protein |
CTD |
PMID:17893922 |
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NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
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G |
Gnaz |
G protein subunit alpha z |
multiple interactions |
ISO |
Morphine promotes the reaction [GNAZ protein binds to RGS17 protein] |
CTD |
PMID:18652891 |
|
NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907
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G |
Gng11 |
G protein subunit gamma 11 |
decreases expression |
ISO |
Morphine results in decreased expression of GNG11 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442
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G |
Gng2 |
G protein subunit gamma 2 |
increases expression |
EXP |
Morphine results in increased expression of GNG2 mRNA |
CTD |
PMID:15183518 |
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NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183
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G |
Gpr6 |
G protein-coupled receptor 6 |
decreases expression |
ISO |
Morphine results in decreased expression of GPR6 mRNA |
CTD |
PMID:21955143 |
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NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624
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G |
Gpr88 |
G-protein coupled receptor 88 |
increases expression decreases expression |
ISO |
Morphine results in increased expression of GPR88 mRNA Morphine deficiency results in decreased expression of GPR88 mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr 2:204,191,443...204,199,576
Ensembl chr 2:204,191,427...204,199,733
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G |
Gprc5b |
G protein-coupled receptor, class C, group 5, member B |
decreases expression |
ISO |
Morphine results in decreased expression of GPRC5B mRNA |
CTD |
PMID:21955143 |
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NCBI chr 1:173,316,904...173,340,933
Ensembl chr 1:173,316,907...173,340,932
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G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
affects response to substance increases localization increases expression decreases phosphorylation affects expression increases phosphorylation multiple interactions decreases expression |
ISO EXP |
GRIA1 protein affects the susceptibility to Morphine Morphine increases localization of Gria1 protein on shell of nucleus accumbens cell surface Morphine increases expression of Gria protein in the nucleus accumbens Morphine increases localization of Gria1 protein on nucleus accumbens cell surface Morphine decreases phosphorylation of Gria1 protein in the caudate-putamen, nucleus accumbens Morphine alters expression of Gria1 protein in prefrontal cortex membrane Morphine withdrawal increases phosphorylation of Gria1 protein in hippocampal formation postsynaptic density Morphine increases expression of Gria1 protein in the striatum Morphine increases expression of Gria1 protein in the central amygdaloid nucleus Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter] Morphine results in increased expression of GRIA1 mRNA Morphine results in decreased expression of GRIA1 mRNA; Morphine results in decreased expression of GRIA1 protein Morphine results in decreased phosphorylation of GRIA1 protein |
CTD RGD |
PMID:11404432 PMID:15183518 PMID:15287884 PMID:23711322 PMID:25643298 PMID:25746394 PMID:34390773 PMID:27225765 PMID:15287884 PMID:31209728 PMID:19077125 PMID:32717192 PMID:31863796 More...
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RGD:11087075, RGD:405818276, RGD:405650668, RGD:405650198, RGD:405649863, RGD:405101691, RGD:405100728, RGD:405100238 |
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
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G |
Gria2 |
glutamate ionotropic receptor AMPA type subunit 2 |
decreases expression |
EXP |
Morphine results in decreased expression of GRIA2 protein |
CTD |
PMID:23711322 |
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NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
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G |
Gria3 |
glutamate ionotropic receptor AMPA type subunit 3 |
decreases expression |
EXP |
Morphine results in decreased expression of GRIA3 mRNA |
CTD |
PMID:15183518 |
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NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096
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G |
Gria4 |
glutamate ionotropic receptor AMPA type subunit 4 |
decreases expression |
EXP |
Morphine results in decreased expression of GRIA4 mRNA |
CTD |
PMID:15183518 |
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NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979
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G |
Grik1 |
glutamate ionotropic receptor kainate type subunit 1 |
multiple interactions affects response to substance |
ISO |
GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form] GRIK1 protein affects the susceptibility to Morphine |
CTD |
PMID:20359526 |
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NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
multiple interactions increases expression increases phosphorylation decreases phosphorylation affects phosphorylation |
ISO EXP |
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein] morphine increases expression of Nr1 protein in cortical neurons morphine increases phosphorylation of Nr1 protein in frontal cortex and cortical neurons Morphine results in increased expression of GRIN1 protein Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]; Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein] Morphine results in decreased phosphorylation of GRIN1 protein Morphine affects the phosphorylation of GRIN1 protein |
CTD RGD |
PMID:15287884 PMID:17996026 PMID:20519536 PMID:20950603 PMID:22713680 PMID:30632088 PMID:30632088 More...
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RGD:401901284, RGD:401901284 |
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
increases expression affects response to substance |
ISO |
Morphine results in increased expression of GRIN2A protein GRIN2A protein affects the susceptibility to Morphine |
CTD |
PMID:12878694 PMID:33609567 |
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NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions increases expression increases phosphorylation |
ISO EXP |
MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein] Morphine results in increased expression of GRIN2B protein Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN2B protein] |
CTD |
PMID:20519536 PMID:22713680 |
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NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Grin2c |
glutamate ionotropic receptor NMDA type subunit 2C |
increases expression |
EXP |
Morphine results in increased expression of GRIN2C mRNA |
CTD |
PMID:15183518 |
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NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
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G |
Grk5 |
G protein-coupled receptor kinase 5 |
increases expression |
EXP |
Morphine results in increased expression of GRK5 mRNA |
CTD |
PMID:15183518 |
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NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
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G |
Grm1 |
glutamate metabotropic receptor 1 |
increases expression |
EXP |
Morphine results in increased expression of GRM1 mRNA |
CTD |
PMID:15183518 |
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NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
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G |
Grm5 |
glutamate metabotropic receptor 5 |
increases expression decreases expression |
ISO |
Morphine results in increased expression of GRM5 mRNA Morphine deficiency results in decreased expression of GRM5 mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases expression multiple interactions |
ISO |
Morphine results in increased expression of GSK3B protein modified form Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form] |
CTD |
PMID:20600172 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Hcrtr1 |
hypocretin receptor 1 |
increases expression |
EXP |
Morphine results in increased expression of HCRTR1 mRNA; Morphine results in increased expression of HCRTR1 protein |
CTD |
PMID:32319158 |
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NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674
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G |
Hdac5 |
histone deacetylase 5 |
increases expression |
EXP |
Morphine results in increased expression of HDAC5 protein |
CTD |
PMID:35461814 |
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NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
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G |
Hint1 |
histidine triad nucleotide binding protein 1 |
multiple interactions increases response to substance |
ISO |
HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein] HINT1 gene mutant form results in increased susceptibility to Morphine |
CTD |
PMID:18652891 PMID:21235400 |
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NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
decreases expression |
ISO |
Morphine results in decreased expression of HMGCS1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
increases expression |
ISO |
Morphine results in increased expression of HMGCS2 mRNA |
CTD |
PMID:20144693 |
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NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
Morphine results in increased expression of HMOX1 protein |
CTD |
PMID:14871405 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hmox2 |
heme oxygenase 2 |
decreases activity increases activity |
EXP |
Morphine results in decreased activity of HMOX2 protein Morphine results in increased activity of HMOX2 protein |
CTD |
PMID:12812915 |
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NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
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G |
Hnrnpdl |
heterogeneous nuclear ribonucleoprotein D-like |
increases expression |
ISO |
Morphine results in increased expression of HNRNPDL mRNA |
CTD |
PMID:20144693 |
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NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506
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G |
Hnrnpl |
heterogeneous nuclear ribonucleoprotein L |
increases expression |
ISO |
Morphine deficiency results in increased expression of HNRNPL mRNA; Morphine results in increased expression of HNRNPL mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553
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G |
Homer1 |
homer scaffold protein 1 |
increases expression |
ISO |
Morphine results in increased expression of HOMER1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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G |
Hp |
haptoglobin |
decreases expression |
EXP |
Morphine results in decreased expression of HP protein |
CTD |
PMID:23056601 |
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NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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G |
Hpca |
hippocalcin |
increases expression decreases expression |
ISO |
Morphine results in increased expression of HPCA mRNA Morphine deficiency results in decreased expression of HPCA mRNA |
CTD |
PMID:21955143 PMID:27126842 |
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NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841
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G |
Hrh1 |
histamine receptor H 1 |
multiple interactions decreases response to substance |
ISO |
Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine] |
CTD |
PMID:12128009 PMID:14569158 |
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NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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G |
Hrh2 |
histamine receptor H 2 |
multiple interactions decreases response to substance |
ISO |
[zolantidine binds to and results in decreased activity of HRH2 protein] which results in increased susceptibility to Morphine; Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine] HRH2 protein results in decreased susceptibility to Morphine; HRH2 results in decreased susceptibility to Morphine |
CTD |
PMID:14569158 PMID:16806305 |
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NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
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G |
Hs6st2 |
heparan sulfate 6-O-sulfotransferase 2 |
increases expression |
ISO |
Morphine results in increased expression of HS6ST2 mRNA |
CTD |
PMID:21178816 |
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NCBI chr X:130,966,547...131,261,629
Ensembl chr X:130,968,385...131,261,492
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
decreases expression |
ISO |
Morphine results in decreased expression of HSD11B1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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G |
Hsp90ab1 |
heat shock protein 90 alpha family class B member 1 |
increases expression |
EXP |
Morphine results in increased expression of HSP90AB1 mRNA |
CTD |
PMID:15497504 |
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NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
decreases expression |
EXP |
Morphine results in decreased expression of HSP90B1 protein |
CTD |
PMID:23056601 |
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NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
multiple interactions increases expression |
EXP |
Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA] Morphine results in increased expression of HSPA1A mRNA; Morphine results in increased expression of HSPA1A protein |
CTD |
PMID:15497504 PMID:23056601 |
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NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
ISO |
Morphine results in increased expression of HSPA5 protein corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]] |
CTD |
PMID:37394652 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
increases expression |
EXP |
Morphine results in increased expression of HSPA8 mRNA |
CTD |
PMID:15497504 |
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NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
increases expression |
EXP |
Morphine results in increased expression of HSPB1 mRNA; Morphine results in increased expression of HSPB1 protein |
CTD |
PMID:15497504 PMID:23056601 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Hspe1 |
heat shock protein family E (Hsp10) member 1 |
increases expression |
EXP |
Morphine results in increased expression of HSPE1 protein |
CTD |
PMID:23056601 |
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NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions decreases expression |
EXP |
4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine Morphine decreases expression of Htr1a mRNA in the dorsal raphe nucleus |
CTD RGD |
PMID:10640309 PMID:24055683 |
RGD:405866344 |
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr3a |
5-hydroxytryptamine receptor 3A |
increases expression |
ISO |
Morphine results in increased expression of HTR3A mRNA |
CTD |
PMID:21178816 |
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NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
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G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression multiple interactions |
EXP |
Morphine results in decreased expression of ICAM1 protein alternative form Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form] |
CTD |
PMID:10070497 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Idh3b |
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta |
decreases expression multiple interactions |
EXP |
Morphine results in decreased expression of IDH3B protein Morphine deficiency affects the reaction [Morphine results in decreased expression of IDH3B protein] |
CTD |
PMID:23056601 |
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NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982
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G |
Ifng |
interferon gamma |
decreases expression multiple interactions |
ISO |
Morphine results in decreased expression of IFNG OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG] |
CTD |
PMID:11590188 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igsf1 |
immunoglobulin superfamily, member 1 |
decreases expression |
ISO |
Morphine results in decreased expression of IGSF1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr X:129,069,891...129,085,331
Ensembl chr X:129,069,896...129,085,139
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
Morphine affects the expression of [IL12A protein binds to IL12B protein] |
CTD |
PMID:16299287 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions affects expression |
ISO |
Morphine affects the expression of [IL12A protein binds to IL12B protein] Morphine affects the expression of IL12B protein |
CTD |
PMID:16299287 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il13 |
interleukin 13 |
increases expression |
ISO |
Morphine results in increased expression of IL13 protein |
CTD |
PMID:16210602 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il1a |
interleukin 1 alpha |
multiple interactions decreases expression |
ISO |
Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]; Dexamethasone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Dexamethasone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]; Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]; Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] |
CTD |
PMID:12182845 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression increases secretion |
EXP ISO |
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL1B mRNA] corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]] Morphine results in increased expression of IL1B mRNA; Morphine results in increased expression of IL1B protein Morphine results in increased secretion of IL1B protein |
CTD |
PMID:12427855 PMID:20178837 PMID:21081778 PMID:22713680 PMID:24756886 PMID:37394652 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
affects response to substance |
ISO |
IL1RN protein affects the susceptibility to Morphine |
CTD |
PMID:15317861 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il2 |
interleukin 2 |
decreases expression multiple interactions |
ISO |
Morphine results in decreased expression of IL2 Morphine results in decreased expression of IL2 mRNA OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2] |
CTD |
PMID:11590188 PMID:23965172 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il4 |
interleukin 4 |
multiple interactions increases expression |
ISO |
[FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein] Morphine results in increased expression of IL4 mRNA; Morphine results in increased expression of IL4 protein CTAP octapeptide inhibits the reaction [Morphine results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Morphine results in increased expression of IL4 mRNA] |
CTD |
PMID:16210602 PMID:23965172 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
increases secretion multiple interactions increases expression |
ISO EXP |
Morphine results in increased secretion of IL6 protein corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]] Morphine results in increased expression of IL6 mRNA; Morphine results in increased expression of IL6 protein Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL6 mRNA] |
CTD |
PMID:12427855 PMID:15317861 PMID:20564181 PMID:21081778 PMID:22713680 PMID:24756886 PMID:37394652 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ing2 |
inhibitor of growth family, member 2 |
multiple interactions |
EXP |
Morphine promotes the reaction [ING2 protein binds to BDNF promoter] |
CTD |
PMID:25643298 |
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NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482
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G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
Morphine results in increased expression of ITGAM mRNA |
CTD |
PMID:37981055 |
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NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; Morphine results in increased phosphorylation of and results in increased activity of JUN protein; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein] |
CTD |
PMID:19292871 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Morphine results in increased expression of JUNB mRNA |
CTD |
PMID:21955143 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Klf7 |
KLF transcription factor 7 |
increases expression multiple interactions |
ISO |
Morphine results in increased expression of KLF7 mRNA; Morphine results in increased expression of KLF7 protein Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA] |
CTD |
PMID:14644156 |
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NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261
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G |
Klrk1 |
killer cell lectin like receptor K1 |
decreases expression |
ISO |
Morphine results in decreased expression of KLRK1 mRNA |
CTD |
PMID:20144693 |
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NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459
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G |
Kmt2a |
lysine methyltransferase 2A |
multiple interactions affects expression |
EXP ISO |
Morphine promotes the reaction [KMT2A protein binds to BDNF promoter] Morphine affects the expression of KMT2A mRNA |
CTD |
PMID:25643298 PMID:33891991 |
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NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
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G |
Krt1 |
keratin 1 |
decreases expression |
EXP |
Morphine results in decreased expression of KRT1 protein |
CTD |
PMID:23056601 |
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NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
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Krt10 |
keratin 10 |
multiple interactions decreases expression |
EXP |
Morphine deficiency inhibits the reaction [Morphine results in decreased expression of KRT10 protein] |
CTD |
PMID:23056601 |
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NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
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Krt2 |
keratin 2 |
decreases expression multiple interactions |
EXP |
Morphine results in decreased expression of KRT2 protein Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT2 protein] |
CTD |
PMID:23056601 |
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NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:132,940,862...132,947,963
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G |
Krt33a |
keratin 33A |
multiple interactions increases expression |
EXP |
Morphine deficiency inhibits the reaction [Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein]]; Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein] |
CTD |
PMID:23056601 |
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NCBI chr10:84,942,584...84,947,544
Ensembl chr10:84,942,573...84,947,478
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Krt5 |
keratin 5 |
decreases expression |
EXP |
Morphine results in decreased expression of KRT5 protein |
CTD |
PMID:23056601 |
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NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850
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G |
Krt8 |
keratin 8 |
multiple interactions decreases expression |
EXP |
Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein]]; Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein] |
CTD |
PMID:23056601 |
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NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
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G |
Lcn2 |
lipocalin 2 |
increases expression |
ISO |
Morphine results in increased expression of LCN2 mRNA |
CTD |
PMID:20144693 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lepr |
leptin receptor |
increases expression |
ISO |
Morphine results in increased expression of LEPR mRNA |
CTD |
PMID:20144693 |
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NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Lhb |
luteinizing hormone subunit beta |
decreases expression |
EXP |
Morphine results in decreased expression of LHB protein |
CTD |
PMID:7022252 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lin7c |
lin-7 homolog C, crumbs cell polarity complex component |
decreases expression |
ISO |
Morphine results in decreased expression of LIN7C mRNA |
CTD |
PMID:21955143 |
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NCBI chr 3:96,406,800...96,417,779
Ensembl chr 3:96,406,813...96,417,728
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G |
Litaf |
lipopolysaccharide-induced TNF factor |
decreases expression |
ISO |
Morphine results in decreased expression of LITAF mRNA |
CTD |
PMID:21955143 |
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NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
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Lmo7 |
LIM domain 7 |
increases expression |
ISO |
Morphine results in increased expression of LMO7 mRNA |
CTD |
PMID:21955143 |
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NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783
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G |
Lmx1b |
LIM homeobox transcription factor 1 beta |
increases expression |
ISO |
Morphine results in increased expression of LMX1B mRNA |
CTD |
PMID:19397953 |
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NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:16,862,195...16,940,899
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G |
Lpl |
lipoprotein lipase |
increases expression |
ISO |
Morphine results in increased expression of LPL mRNA |
CTD |
PMID:21955143 |
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Lrp1 |
LDL receptor related protein 1 |
decreases expression |
ISO |
Morphine results in decreased expression of LRP1 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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G |
Lrpprc |
leucine-rich pentatricopeptide repeat containing |
increases expression |
ISO |
Morphine results in increased expression of LRPPRC mRNA |
CTD |
PMID:20144693 |
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NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293
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G |
Map2 |
microtubule-associated protein 2 |
decreases expression |
EXP |
Morphine results in decreased expression of MAP2 mRNA |
CTD |
PMID:15183518 |
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NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases expression increases phosphorylation multiple interactions |
ISO EXP |
Morphine results in increased expression of MAPK1 protein modified form Morphine results in increased phosphorylation of MAPK1 protein [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] Morphine deficiency results in increased phosphorylation of MAPK1 protein; Morphine results in increased phosphorylation of MAPK1 protein [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein] ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:15196791 PMID:20359526 PMID:20519536 PMID:21235400 PMID:21483469 PMID:21600884 PMID:23965172 PMID:24398105 PMID:27461790 PMID:32319158 PMID:33609567 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
increases expression |
EXP |
Morphine results in increased expression of MAPK14 protein |
CTD |
PMID:23056601 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO EXP |
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein] Morphine deficiency results in increased phosphorylation of MAPK3 protein; Morphine results in increased phosphorylation of MAPK3 protein [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:20519536 PMID:21235400 PMID:21483469 PMID:21600884 PMID:23965172 PMID:24398105 PMID:27461790 PMID:32319158 PMID:33609567 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapt |
microtubule-associated protein tau |
increases expression |
EXP |
Morphine results in increased expression of MAPT mRNA |
CTD |
PMID:15183518 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Marcks |
myristoylated alanine rich protein kinase C substrate |
decreases expression |
EXP |
Morphine results in decreased expression of MARCKS protein |
CTD |
PMID:23056601 |
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NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
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G |
Mavs |
mitochondrial antiviral signaling protein |
increases expression |
EXP |
Morphine results in increased expression of MAVS protein |
CTD |
PMID:23056601 |
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NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094
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G |
Mbd1 |
methyl-CpG binding domain protein 1 |
affects expression |
ISO |
Morphine affects the expression of MBD1 mRNA |
CTD |
PMID:33891991 |
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NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554
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G |
Mbd3 |
methyl-CpG binding domain protein 3 |
decreases expression |
ISO |
Morphine results in decreased expression of MBD3 mRNA |
CTD |
PMID:33891991 |
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NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165
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G |
Mbd4 |
methyl-CpG binding domain 4 DNA glycosylase |
affects expression |
ISO |
Morphine affects the expression of MBD4 mRNA |
CTD |
PMID:33891991 |
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NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
increases expression |
ISO |
Morphine results in increased expression of MCL1 mRNA |
CTD |
PMID:20144693 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mctp1 |
multiple C2 and transmembrane domain containing 1 |
increases expression |
ISO |
Morphine results in increased expression of MCTP1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833
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G |
Me3 |
malic enzyme 3 |
increases expression |
ISO |
Morphine results in increased expression of ME3 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132
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G |
Mir107 |
microRNA 107 |
decreases expression |
ISO |
Morphine results in decreased expression of MIR107 |
CTD |
PMID:20564181 |
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NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853
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G |
Mir132 |
microRNA 132 |
increases expression |
ISO |
Morphine results in increased expression of MIR132 |
CTD |
PMID:20564181 |
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NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
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G |
Mir146a |
microRNA 146a |
increases expression |
ISO |
Morphine results in increased expression of MIR146A |
CTD |
PMID:20564181 |
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NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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G |
Mir150 |
microRNA 150 |
increases expression |
ISO |
Morphine results in increased expression of MIR150 |
CTD |
PMID:20564181 |
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NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108
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G |
Mir155 |
microRNA 155 |
increases expression |
ISO |
Morphine results in increased expression of MIR155 |
CTD |
PMID:20564181 |
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NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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G |
Mir15b |
microRNA 15b |
increases expression |
ISO |
Morphine results in increased expression of MIR15B |
CTD |
PMID:20564181 |
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NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
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G |
Mir191 |
microRNA 191 |
decreases expression |
ISO |
Morphine results in decreased expression of MIR191 |
CTD |
PMID:20564181 |
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NCBI chr 8:109,264,098...109,264,188
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G |
Mir21 |
microRNA 21 |
decreases expression |
ISO |
Morphine results in decreased expression of MIR21 |
CTD |
PMID:20564181 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mir221 |
microRNA 221 |
increases expression |
ISO |
Morphine results in increased expression of MIR221 |
CTD |
PMID:20564181 |
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NCBI chr X:3,429,465...3,429,573
Ensembl chr X:3,429,465...3,429,573
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G |
Mir23a |
microRNA 23a |
increases expression |
ISO |
Morphine results in increased expression of MIR23A |
CTD |
PMID:20564181 |
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NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071
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G |
Mir23b |
microRNA 23b |
increases expression |
ISO |
Morphine results in increased expression of MIR23B |
CTD |
PMID:20564181 |
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NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763
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G |
Mir26a |
microRNA 26a |
decreases expression |
ISO |
Morphine results in decreased expression of MIR26A1 |
CTD |
PMID:20564181 |
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NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378
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G |
Mir26b |
microRNA 26b |
decreases expression |
ISO |
Morphine results in decreased expression of MIR26B |
CTD |
PMID:20564181 |
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NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680
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G |
Mir320a |
microRNA 320a |
decreases expression |
ISO |
Morphine results in decreased expression of MIR320A |
CTD |
PMID:20564181 |
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NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
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G |
Mir423 |
microRNA 423 |
decreases expression |
ISO |
Morphine results in decreased expression of MIR423 |
CTD |
PMID:20564181 |
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NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226
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G |
Mir99b |
microRNA 99b |
decreases expression |
ISO |
Morphine results in decreased expression of MIR99B |
CTD |
PMID:20564181 |
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NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090
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G |
Mme |
membrane metallo-endopeptidase |
multiple interactions increases activity |
EXP |
Naloxone inhibits the reaction [Morphine results in increased activity of MME protein]; phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein] |
CTD |
PMID:10070497 |
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NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases activity |
ISO |
[7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein] Morphine results in increased activity of MMP9 protein |
CTD |
PMID:20519536 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpeg1 |
macrophage expressed 1 |
increases expression |
ISO |
Morphine results in increased expression of MPEG1 mRNA |
CTD |
PMID:21178816 |
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NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855
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G |
Myo19 |
myosin XIX |
decreases expression |
ISO |
Morphine results in decreased expression of MYO19 mRNA |
CTD |
PMID:21178816 |
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NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450
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G |
Naip6 |
NLR family, apoptosis inhibitory protein 6 |
increases expression |
EXP |
Morphine results in increased expression of NAIP mRNA |
CTD |
PMID:15183518 |
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NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542
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G |
Nav1 |
neuron navigator 1 |
decreases expression |
ISO |
Morphine results in decreased expression of NAV1 mRNA |
CTD |
PMID:21178816 |
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NCBI chr13:46,866,972...47,119,368
Ensembl chr13:46,873,689...47,126,449
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G |
Ncam1 |
neural cell adhesion molecule 1 |
decreases expression |
EXP |
Morphine results in decreased expression of NCAM1 protein modified form |
CTD |
PMID:15673448 |
|
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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G |
Ndufab1 |
NADH:ubiquinone oxidoreductase subunit AB1 |
affects expression |
ISO |
Morphine affects the expression of NDUFAB1 mRNA |
CTD |
PMID:20144693 |
|
NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
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G |
Ndufv2 |
NADH:ubiquinone oxidoreductase core subunit V2 |
increases expression |
EXP |
Morphine results in increased expression of NDUFV2 protein |
CTD |
PMID:23056601 |
|
NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
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G |
Nefh |
neurofilament heavy chain |
increases expression |
EXP |
Morphine results in increased expression of NEFH mRNA |
CTD |
PMID:15183518 |
|
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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G |
Nes |
nestin |
decreases expression |
ISO |
Morphine results in decreased expression of NES mRNA |
CTD |
PMID:26877219 |
|
NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
increases expression |
EXP |
Morphine results in increased expression of NFKB1 mRNA |
CTD |
PMID:15183518 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
increases phosphorylation affects response to substance increases expression increases degradation multiple interactions |
ISO EXP |
Morphine results in increased phosphorylation of NFKBIA protein NFKBIA protein affects the susceptibility to Morphine Morphine results in increased expression of NFKBIA protein Morphine results in increased degradation of NFKBIA protein Morphine results in increased expression of NFKBIA mRNA; Morphine results in increased expression of NFKBIA protein Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Cycloheximide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Morphine inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]] |
CTD |
PMID:17542780 PMID:19070643 PMID:22258905 PMID:24068670 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Ninj1 |
ninjurin 1 |
increases expression |
ISO |
Morphine results in increased expression of NINJ1 mRNA |
CTD |
PMID:19397953 |
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NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions increases expression |
ISO |
corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]] |
CTD |
PMID:37394652 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
[7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein] Morphine results in decreased expression of NOS1 protein PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein] |
CTD |
PMID:16598705 PMID:20519536 PMID:20568289 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
increases expression multiple interactions affects response to substance |
ISO |
Morphine results in increased expression of NOS2 mRNA; Morphine results in increased expression of NOS2 protein corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of NOS2 protein]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]] NOS2 protein affects the susceptibility to Morphine |
CTD |
PMID:11590188 PMID:15220775 PMID:16325209 PMID:19751225 PMID:24756886 PMID:37394652 More...
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Npy |
neuropeptide Y |
increases expression |
ISO |
Morphine results in increased expression of NPY mRNA |
CTD |
PMID:20144693 PMID:21178816 |
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NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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G |
Npy1r |
neuropeptide Y receptor Y1 |
decreases expression |
ISO |
Morphine results in decreased expression of NPY1R mRNA |
CTD |
PMID:20144693 |
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NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
EXP |
[Mifepristone binds to and results in decreased activity of NR3C1 protein] which results in decreased susceptibility to Morphine |
CTD |
PMID:15014116 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
increases expression |
ISO |
Morphine results in increased expression of NR4A1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
multiple interactions decreases expression affects response to substance |
ISO EXP |
BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine] Morphine results in decreased expression of NR4A2 mRNA Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter] |
CTD |
PMID:25643298 |
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NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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G |
Nrcam |
neuronal cell adhesion molecule |
increases expression |
EXP |
Morphine results in increased expression of NRCAM mRNA; Morphine results in increased expression of NRCAM mRNA alternative form |
CTD |
PMID:16123759 |
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NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
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G |
Nrn1 |
neuritin 1 |
decreases expression |
ISO |
Morphine results in decreased expression of NRN1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,129,977...28,138,896
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G |
Nrxn3 |
neurexin 3 |
increases expression |
ISO |
Morphine results in increased expression of NRXN3 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044
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G |
Ntng1 |
netrin G1 |
decreases expression |
ISO |
Morphine results in decreased expression of NTNG1 mRNA |
CTD |
PMID:21955143 |
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NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997
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G |
Ntsr1 |
neurotensin receptor 1 |
affects response to substance |
ISO |
NTSR1 protein affects the susceptibility to Morphine |
CTD |
PMID:20727387 |
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NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377
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G |
Opalin |
oligodendrocytic myelin paranodal and inner loop protein |
decreases expression |
ISO |
Morphine results in decreased expression of OPALIN mRNA |
CTD |
PMID:21955143 |
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NCBI chr 1:239,891,137...239,909,388
Ensembl chr 1:239,891,142...239,908,788
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G |
Oprd1 |
opioid receptor, delta 1 |
multiple interactions increases expression affects binding |
ISO
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