nickel ion - Ontology Report - Rat Genome Database

Nickel ion decreases activity of purified Hmbs protein

RGD

PMID:6732900

RGD:25394584

NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957

nickel sulfate

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Aass

aminoadipate-semialdehyde synthase

decreases expression

nickel sulfate results in decreased expression of AASS mRNA

NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136

Abca5

ATP binding cassette subfamily A member 5

increases expression

nickel sulfate results in increased expression of ABCA5 mRNA

NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976

Abca6

ATP binding cassette subfamily A member 6

decreases expression

nickel sulfate results in decreased expression of ABCA6 mRNA

NCBI chr10:95,142,805...95,212,087
Ensembl chr10:95,142,966...95,211,530

Abcc1

ATP binding cassette subfamily C member 1

increases expression

nickel sulfate results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

Abcc3

ATP binding cassette subfamily C member 3

increases expression

nickel sulfate results in increased expression of ABCC3 mRNA

PMID:16314067 PMID:22714537

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

Abhd10

abhydrolase domain containing 10, depalmitoylase

decreases expression

nickel sulfate results in decreased expression of ABHD10 mRNA

NCBI chr11:55,081,273...55,095,044
Ensembl chr11:55,081,049...55,107,866

Abhd12

abhydrolase domain containing 12, lysophospholipase

decreases expression

nickel sulfate results in decreased expression of ABHD12 mRNA

NCBI chr 3:139,659,315...139,719,529
Ensembl chr 3:139,659,317...139,719,564

Abhd17a

abhydrolase domain containing 17A, depalmitoylase

increases expression

nickel sulfate results in increased expression of ABHD17A mRNA

NCBI chr 7:9,124,332...9,132,762
Ensembl chr 7:9,124,332...9,130,762

Abi3bp

ABI family member 3 binding protein

increases expression

nickel sulfate results in increased expression of ABI3BP mRNA

NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929

Ablim1

actin-binding LIM protein 1

decreases expression

nickel sulfate results in decreased expression of ABLIM1 mRNA

NCBI chr 1:256,083,747...256,372,075
Ensembl chr 1:256,084,297...256,371,969

Abraxas1

abraxas 1, BRCA1 A complex subunit

decreases expression

nickel sulfate results in decreased expression of ABRAXAS1 mRNA

NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622

Acbd7

acyl-CoA binding domain containing 7

decreases expression

nickel sulfate results in decreased expression of ACBD7 mRNA

NCBI chr17:74,903,936...74,909,977
Ensembl chr17:74,903,177...74,905,811

Aco1

aconitase 1

decreases expression

nickel sulfate results in decreased expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

Aco2

aconitase 2

increases expression

nickel sulfate results in increased expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

Acot13

acyl-CoA thioesterase 13

increases expression

nickel sulfate results in increased expression of ACOT13 mRNA

NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851

Acot2

acyl-CoA thioesterase 2

increases expression

nickel sulfate results in increased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

Acot4

acyl-CoA thioesterase 4

decreases expression

nickel sulfate results in decreased expression of ACOT4 mRNA

NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917

Acox2

acyl-CoA oxidase 2

increases expression

nickel sulfate results in increased expression of ACOX2 mRNA

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

Acsl5

acyl-CoA synthetase long-chain family member 5

decreases expression

nickel sulfate results in decreased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

Acss2

acyl-CoA synthetase short-chain family member 2

increases expression

nickel sulfate results in increased expression of ACSS2 mRNA

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

Acta1

actin, alpha 1, skeletal muscle

increases expression

nickel sulfate results in increased expression of ACTA1 mRNA

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

Actc1

actin, alpha, cardiac muscle 1

decreases expression

nickel sulfate results in decreased expression of ACTC1 mRNA

NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523

Actg2

actin gamma 2, smooth muscle

increases expression

nickel sulfate results in increased expression of ACTG2 mRNA

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

Acvr1

activin A receptor type 1

increases expression

nickel sulfate results in increased expression of ACVR1 mRNA

NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241

Acvr1b

activin A receptor type 1B

increases expression

nickel sulfate results in increased expression of ACVR1B mRNA

NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673

Ada

adenosine deaminase

increases expression

nickel sulfate results in increased expression of ADA mRNA

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

Adam12

ADAM metallopeptidase domain 12

decreases expression

nickel sulfate results in decreased expression of ADAM12 mRNA

NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667

Adam19

ADAM metallopeptidase domain 19

decreases expression

nickel sulfate results in decreased expression of ADAM19 mRNA

NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105

Adam32

ADAM metallopeptidase domain 32

decreases expression

nickel sulfate results in decreased expression of ADAM32 mRNA

NCBI chr16:67,102,384...67,212,163
Ensembl chr16:67,102,320...67,212,161

Adam8

ADAM metallopeptidase domain 8

increases expression

nickel sulfate results in increased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

Adamts12

ADAM metallopeptidase with thrombospondin type 1 motif, 12

decreases expression

nickel sulfate results in decreased expression of ADAMTS12 mRNA

NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629

Adamts3

ADAM metallopeptidase with thrombospondin type 1, motif 3

decreases expression

nickel sulfate results in decreased expression of ADAMTS3 mRNA

NCBI chr14:18,231,128...18,437,771
Ensembl chr14:18,231,165...18,435,556

Adamtsl1

ADAMTS-like 1

decreases expression

nickel sulfate results in decreased expression of ADAMTSL1 mRNA

NCBI chr 5:99,964,406...100,919,786
Ensembl chr 5:99,964,486...100,918,384

Adamtsl3

ADAMTS-like 3

decreases expression

nickel sulfate results in decreased expression of ADAMTSL3 mRNA

NCBI chr 1:136,288,793...136,596,986
Ensembl chr 1:136,288,793...136,596,986

Adck2

aarF domain containing kinase 2

increases expression

nickel sulfate results in increased expression of ADCK2 mRNA

NCBI chr 4:68,348,853...68,362,725
Ensembl chr 4:68,348,864...68,374,608

Adcy7

adenylate cyclase 7

decreases expression

nickel sulfate results in decreased expression of ADCY7 mRNA

NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311

Add3

adducin 3

decreases expression

nickel sulfate results in decreased expression of ADD3 mRNA

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

Adgrg1

adhesion G protein-coupled receptor G1

increases expression

nickel sulfate results in increased expression of ADGRG1 mRNA

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

Adm

adrenomedullin

increases expression
decreases expression

nickel sulfate results in increased expression of ADM mRNA
nickel sulfate results in decreased expression of ADM mRNA

PMID:18651567 PMID:22714537

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

Adora2a

adenosine A2a receptor

increases expression

nickel sulfate results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

Adora2b

adenosine A2B receptor

increases expression

nickel sulfate results in increased expression of ADORA2B mRNA

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

Afap1l2

actin filament associated protein 1-like 2

decreases expression

nickel sulfate results in decreased expression of AFAP1L2 mRNA

NCBI chr 1:255,964,238...256,060,828
Ensembl chr 1:255,964,238...256,060,820

Aff3

ALF transcription elongation factor 3

increases expression

nickel sulfate results in increased expression of AFF3 mRNA

NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247

Agbl5

AGBL carboxypeptidase 5

increases expression

nickel sulfate results in increased expression of AGBL5 mRNA

NCBI chr 6:25,472,333...25,492,173
Ensembl chr 6:25,472,333...25,490,738

Agmat

agmatinase

decreases expression

nickel sulfate results in decreased expression of AGMAT mRNA

NCBI chr 5:154,043,665...154,074,278
Ensembl chr 5:154,060,151...154,074,276

Agtpbp1

ATP/GTP binding carboxypeptidase 1

decreases expression

nickel sulfate results in decreased expression of AGTPBP1 mRNA

NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869

Ahcyl1

adenosylhomocysteinase-like 1

affects expression

nickel sulfate affects the expression of AHCYL1 mRNA

NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815

Ahdc1

AT hook, DNA binding motif, containing 1

increases expression

nickel sulfate results in increased expression of AHDC1 mRNA

NCBI chr 5:145,228,228...145,294,170
Ensembl chr 5:145,228,227...145,294,145

Ahnak2

AHNAK nucleoprotein 2

increases expression

nickel sulfate results in increased expression of AHNAK2 mRNA

NCBI chr 6:131,830,668...131,876,311
Ensembl chr 6:131,831,454...131,854,463

Akap11

A-kinase anchoring protein 11

decreases expression

nickel sulfate results in decreased expression of AKAP11 mRNA

NCBI chr15:53,911,635...53,956,138
Ensembl chr15:53,911,657...53,941,605

Akr1b1

aldo-keto reductase family 1 member B1

increases expression

nickel sulfate results in increased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

Akr1b10

aldo-keto reductase family 1 member B10

increases expression

nickel sulfate results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

Akr1c1

aldo-keto reductase family 1, member C1

increases expression

nickel sulfate results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

Akr1c3

aldo-keto reductase family 1, member C3

increases expression

nickel sulfate results in increased expression of AKR1C3 mRNA

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

Akr1e2

aldo-keto reductase family 1, member E2

decreases expression

nickel sulfate results in decreased expression of AKR1E2 mRNA

NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441

Akt1

AKT serine/threonine kinase 1

increases phosphorylation

nickel sulfate results in increased phosphorylation of AKT1 protein

PMID:23445166

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Alcam

activated leukocyte cell adhesion molecule

increases expression

nickel sulfate results in increased expression of ALCAM mRNA

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

Aldh1l2

aldehyde dehydrogenase 1 family, member L2

decreases expression

nickel sulfate results in decreased expression of ALDH1L2 mRNA

NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776

Aldh3a2

aldehyde dehydrogenase 3 family, member A2

increases expression

nickel sulfate results in increased expression of ALDH3A2 mRNA

NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281

Aldh5a1

aldehyde dehydrogenase 5 family, member A1

increases expression

nickel sulfate results in increased expression of ALDH5A1 mRNA

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

Aldoc

aldolase, fructose-bisphosphate C

increases expression

nickel sulfate results in increased expression of ALDOC mRNA

PMID:17382205 PMID:22714537

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

Alg5

ALG5, dolichyl-phosphate beta-glucosyltransferase

decreases expression

nickel sulfate results in decreased expression of ALG5 mRNA

NCBI chr 2:138,936,998...138,951,228
Ensembl chr 2:138,936,993...138,951,216

Alox5ap

arachidonate 5-lipoxygenase activating protein

decreases expression

nickel sulfate results in decreased expression of ALOX5AP mRNA

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

Alpk2

alpha-kinase 2

decreases expression

nickel sulfate results in decreased expression of ALPK2 mRNA

NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258

Alyref

Aly/REF export factor

increases expression

nickel sulfate results in increased expression of THOC4 mRNA

NCBI chr10:105,871,424...105,875,076
Ensembl chr10:105,871,306...105,875,069

Ampd3

adenosine monophosphate deaminase 3

affects expression

nickel sulfate affects the expression of AMPD3 mRNA

NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887

Angptl4

angiopoietin-like 4

multiple interactions
increases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of ANGPTL4 mRNA
nickel sulfate results in increased expression of ANGPTL4 mRNA

PMID:16166746 PMID:17382205 PMID:18832182

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

Ankh

ANKH inorganic pyrophosphate transport regulator

increases expression

nickel sulfate results in increased expression of ANKH mRNA

NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187

Ankrd1

ankyrin repeat domain 1

decreases expression

nickel sulfate results in decreased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

Ankrd6

ankyrin repeat domain 6

increases expression

nickel sulfate results in increased expression of ANKRD6 mRNA

NCBI chr 5:47,197,981...47,343,183
Ensembl chr 5:47,202,873...47,343,090

Ano2

anoctamin 2

decreases expression

nickel sulfate results in decreased expression of ANO2 mRNA

NCBI chr 4:158,514,200...158,855,639
Ensembl chr 4:158,496,014...158,855,651

Anpep

alanyl aminopeptidase, membrane

decreases expression

nickel sulfate results in decreased expression of ANPEP mRNA

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

Antxr1

ANTXR cell adhesion molecule 1

increases expression

nickel sulfate results in increased expression of ANTXR1 mRNA

NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232

Antxr2

ANTXR cell adhesion molecule 2

increases expression
decreases expression

nickel sulfate results in increased expression of ANTXR2 mRNA
nickel sulfate results in decreased expression of ANTXR2 mRNA

NCBI chr14:11,541,718...11,682,110
Ensembl chr14:11,541,772...11,682,094

Anxa1

annexin A1

increases expression

nickel sulfate results in increased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

Anxa2

annexin A2

increases expression

nickel sulfate results in increased expression of ANXA2 mRNA

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

Anxa3

annexin A3

decreases expression

nickel sulfate results in decreased expression of ANXA3 mRNA

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

Aoc1

amine oxidase, copper containing 1

increases expression

nickel sulfate results in increased expression of AOC1 mRNA

NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840

Aox1

aldehyde oxidase 1

decreases expression

nickel sulfate results in decreased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

Ap1ar

adaptor-related protein complex 1 associated regulatory protein

decreases expression

nickel sulfate results in decreased expression of AP1AR mRNA

NCBI chr 2:216,276,631...216,309,020
Ensembl chr 2:216,276,631...216,309,013

Apba2

amyloid beta precursor protein binding family A member 2

increases expression

nickel sulfate results in increased expression of APBA2 mRNA

NCBI chr 1:118,053,270...118,286,858
Ensembl chr 1:118,103,219...118,285,699

Apmap

adipocyte plasma membrane associated protein

decreases expression

nickel sulfate results in decreased expression of APMAP mRNA

NCBI chr 3:139,409,021...139,437,296
Ensembl chr 3:139,409,022...139,437,341

Apoe

apolipoprotein E

decreases expression
increases expression

nickel sulfate results in decreased expression of APOE mRNA
nickel sulfate results in increased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

Aqp3

aquaporin 3 (Gill blood group)

decreases expression

nickel sulfate results in decreased expression of AQP3 mRNA

PMID:16780908 PMID:20713136

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

Aqp9

aquaporin 9

decreases expression

nickel sulfate results in decreased expression of AQP9 mRNA

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

androgen receptor

increases expression

nickel sulfate results in increased expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

Arap2

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

decreases expression

nickel sulfate results in decreased expression of ARAP2 mRNA

NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154

Areg

amphiregulin

increases expression
decreases expression

nickel sulfate results in increased expression of AREG mRNA
nickel sulfate results in decreased expression of AREG mRNA

PMID:16166746 PMID:18651567 PMID:22714537

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

Arfip2

ARF interacting protein 2

increases expression

nickel sulfate results in increased expression of ARFIP2 mRNA

NCBI chr 1:159,974,255...159,980,398
Ensembl chr 1:159,974,201...159,980,336

Arg2

arginase 2

increases expression

nickel sulfate results in increased expression of ARG2 mRNA

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

Arhgap17

Rho GTPase activating protein 17

decreases expression

nickel sulfate results in decreased expression of ARHGAP17 mRNA

NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854

Arhgap18

Rho GTPase activating protein 18

increases expression

nickel sulfate results in increased expression of ARHGAP18 mRNA

NCBI chr 1:18,403,531...18,637,306
Ensembl chr 1:18,403,537...18,637,256

Arhgap42

Rho GTPase activating protein 42

decreases expression

nickel sulfate results in decreased expression of ARHGAP42 mRNA

NCBI chr 8:6,154,759...6,384,497
Ensembl chr 8:6,156,865...6,384,870

Arhgap44

Rho GTPase activating protein 44

increases expression

nickel sulfate results in increased expression of ARHGAP44 mRNA

NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297

Arhgap5

Rho GTPase activating protein 5

decreases expression

nickel sulfate results in decreased expression of ARHGAP5 mRNA

NCBI chr 6:69,975,904...70,039,299
Ensembl chr 6:69,976,214...70,037,660

Arhgef9

Cdc42 guanine nucleotide exchange factor 9

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of ARHGEF9 mRNA

NCBI chr X:59,919,560...60,077,538
Ensembl chr X:59,920,870...60,077,513

Arl10

ARF like GTPase 10

decreases expression

nickel sulfate results in decreased expression of ARL10 mRNA

NCBI chr17:10,030,213...10,038,625
Ensembl chr17:10,030,213...10,038,703

Arl4c

ARF like GTPase 4C

increases expression

nickel sulfate results in increased expression of ARL4C mRNA

PMID:17374397 PMID:18651567

NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513

Armcx1

armadillo repeat containing, X-linked 1

decreases expression

nickel sulfate results in decreased expression of ARMCX1 mRNA

NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299

Armcx2

armadillo repeat containing, X-linked 2

decreases expression

nickel sulfate results in decreased expression of ARMCX2 mRNA

NCBI chr X:97,980,662...97,985,523
Ensembl chr X:97,980,660...97,985,552

Armcx4

armadillo repeat containing, X-linked 4

decreases expression

nickel sulfate results in decreased expression of ARMCX4 mRNA

NCBI chr X:97,860,526...97,870,912
Ensembl chr X:97,860,629...97,870,912

Arnt

aryl hydrocarbon receptor nuclear translocator

affects localization

nickel sulfate affects the localization of ARNT protein

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

Arnt2

aryl hydrocarbon receptor nuclear translocator 2

increases expression

nickel sulfate results in increased expression of ARNT2 mRNA

NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153

Arpc2

actin related protein 2/3 complex, subunit 2

increases expression

nickel sulfate results in increased expression of ARPC2 mRNA

NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471

Arpc4

actin related protein 2/3 complex, subunit 4

increases expression

nickel sulfate results in increased expression of ARPC4 mRNA

NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785

Arrb1

arrestin, beta 1

increases expression

nickel sulfate results in increased expression of ARRB1 mRNA

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

Asah1

N-acylsphingosine amidohydrolase 1

decreases expression

nickel sulfate results in decreased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

Asgr1

asialoglycoprotein receptor 1

decreases expression

nickel sulfate results in decreased expression of ASGR1 mRNA

NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631

Asgr2

asialoglycoprotein receptor 2

decreases expression

nickel sulfate results in decreased expression of ASGR2 mRNA

NCBI chr10:54,821,407...54,834,624
Ensembl chr10:54,821,438...54,834,617

Asmtl

acetylserotonin O-methyltransferase-like

increases expression

nickel sulfate results in increased expression of ASMTL mRNA

NCBI chr12:16,315,335...16,318,083
Ensembl chr12:16,315,414...16,318,080

Ass1

argininosuccinate synthase 1

increases expression

nickel sulfate results in increased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

Atat1

alpha tubulin acetyltransferase 1

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of ATAT1 mRNA

NCBI chr20:2,844,595...2,857,809
Ensembl chr20:2,844,616...2,861,964

Atf3

activating transcription factor 3

increases expression

nickel sulfate results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

Atf6

activating transcription factor 6

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

Atl1

atlastin GTPase 1

decreases expression

nickel sulfate results in decreased expression of ATL1 mRNA

NCBI chr 6:88,377,168...88,475,242
Ensembl chr 6:88,377,239...88,475,204

Atl3

atlastin GTPase 3

decreases expression

nickel sulfate results in decreased expression of ATL3 mRNA

NCBI chr 1:204,680,958...204,727,360
Ensembl chr 1:204,680,968...204,723,354

Atp11a

ATPase phospholipid transporting 11A

decreases expression

nickel sulfate results in decreased expression of ATP11A mRNA

NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640

Atp1b1

ATPase Na+/K+ transporting subunit beta 1

decreases expression

nickel sulfate results in decreased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

Atp1b3

ATPase Na+/K+ transporting subunit beta 3

increases expression
decreases expression

nickel sulfate results in increased expression of ATP1B3 mRNA
nickel sulfate results in decreased expression of ATP1B3 mRNA

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
Ensembl chr 8:96,910,309...96,941,598

Atp2b4

ATPase plasma membrane Ca2+ transporting 4

decreases expression

nickel sulfate results in decreased expression of ATP2B4 mRNA

NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246

Atp6v1a

ATPase H+ transporting V1 subunit A

decreases expression

nickel sulfate results in decreased expression of ATP6V1A mRNA

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

Atp8b2

ATPase phospholipid transporting 8B2

decreases expression

nickel sulfate results in decreased expression of ATP8B2 mRNA

NCBI chr 2:175,378,514...175,402,265
Ensembl chr 2:175,378,517...175,401,883

Atp9a

ATPase phospholipid transporting 9A (putative)

increases expression

nickel sulfate results in increased expression of ATP9A mRNA

NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818

Atrn

attractin

decreases expression

nickel sulfate results in decreased expression of ATRN mRNA

NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322

Atxn1

ataxin 1

increases expression

nickel sulfate results in increased expression of ATXN1 mRNA

NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360

Atxn7l1

ataxin 7-like 1

increases expression

nickel sulfate results in increased expression of ATXN7L1 mRNA

NCBI chr 6:49,759,876...49,982,323
Ensembl chr 6:49,759,883...49,982,320

Auts2

activator of transcription and developmental regulator AUTS2

increases expression

nickel sulfate results in increased expression of AUTS2 mRNA

NCBI chr12:24,104,187...25,194,123
Ensembl chr12:24,104,192...25,194,416

Azin1

antizyme inhibitor 1

decreases expression

nickel sulfate results in decreased expression of AZIN1 mRNA

NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578

B3gat1

beta-1,3-glucuronyltransferase 1

decreases expression

nickel sulfate results in decreased expression of B3GAT1 mRNA

NCBI chr 8:25,087,123...25,114,692
Ensembl chr 8:25,087,547...25,113,395

B3gnt5

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

increases expression

nickel sulfate results in increased expression of B3GNT5 mRNA

NCBI chr11:81,141,102...81,153,206
Ensembl chr11:81,140,599...81,156,166

B4galnt1

beta-1,4-N-acetyl-galactosaminyl transferase 1

increases expression

nickel sulfate results in increased expression of B4GALNT1 mRNA

NCBI chr 7:62,988,429...62,996,190
Ensembl chr 7:62,988,930...62,996,190

Bach1

BTB domain and CNC homolog 1

increases expression

nickel sulfate results in increased expression of BACH1 mRNA

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

Baiap2l1

BAR/IMD domain containing adaptor protein 2 like 1

increases expression

nickel sulfate results in increased expression of BAIAP2L1 mRNA

NCBI chr12:10,250,434...10,339,937
Ensembl chr12:10,250,473...10,339,928

Bak1

BCL2-antagonist/killer 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]
nickel sulfate results in increased expression of BAK1 mRNA; nickel sulfate results in increased expression of BAK1 protein

PMID:28296042

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

Bambi

BMP and activin membrane-bound inhibitor

increases expression

nickel sulfate results in increased expression of BAMBI mRNA

PMID:20146380

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

Bax

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

sesamin inhibits the reaction [nickel sulfate results in increased expression of BAX protein]
pyrazolanthrone inhibits the reaction [nickel sulfate results in increased expression of BAX protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of BAX protein]
nickel sulfate results in increased expression of BAX mRNA; nickel sulfate results in increased expression of BAX protein

PMID:23317420 PMID:35499276

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Bbs5

Bardet-Biedl syndrome 5

increases expression

nickel sulfate results in increased expression of BBS5 mRNA

NCBI chr 3:54,410,429...54,431,831
Ensembl chr 3:54,410,775...54,431,829

Bcar1

BCAR1 scaffold protein, Cas family member

decreases expression

nickel sulfate results in decreased expression of BCAR1 mRNA

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

Bcl11a

BCL11 transcription factor A

decreases expression

nickel sulfate results in decreased expression of BCL11A mRNA

NCBI chr14:98,029,018...98,124,181
Ensembl chr14:98,030,461...98,124,180

Bcl2

BCL2, apoptosis regulator

increases expression
decreases expression
multiple interactions

nickel sulfate results in increased expression of BCL2 protein
nickel sulfate results in decreased expression of BCL2 protein
sesamin inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]
nickel sulfate results in decreased expression of BCL2 mRNA; nickel sulfate results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]; Selenium inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]

PMID:21776270 PMID:23317420 PMID:34612572 PMID:35499276

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

Bcl2a1

BCL2-related protein A1

increases expression

nickel sulfate results in increased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

Bcl2l1

Bcl2-like 1

increases expression
multiple interactions
decreases expression

nickel sulfate results in increased expression of BCL2L1 protein
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of BCL2L1 protein]
nickel sulfate results in decreased expression of BCL2L1 mRNA; nickel sulfate results in decreased expression of BCL2L1 protein

PMID:21776270 PMID:35499276

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

Bcl2l11

Bcl2-like 11

increases expression

nickel sulfate results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

Bcl9

BCL9, transcription coactivator

increases expression

nickel sulfate results in increased expression of BCL9 mRNA

NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435

Bdh1

3-hydroxybutyrate dehydrogenase 1

decreases expression

nickel sulfate results in decreased expression of BDH1 mRNA

NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671

Bex2

brain expressed X-linked 2

decreases expression

nickel sulfate results in decreased expression of BEX1 mRNA

NCBI chr X:99,019,847...99,021,375
Ensembl chr X:99,019,000...99,021,503

Bex4

brain expressed, X-linked 4

decreases expression

nickel sulfate results in decreased expression of BEX4 mRNA

NCBI chr X:99,131,985...99,133,417
Ensembl chr X:99,131,942...99,133,531

Bhlhe40

basic helix-loop-helix family, member e40

increases expression

nickel sulfate results in increased expression of BHLHE40 mRNA

PMID:18651567 PMID:22714537

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

Bicc1

BicC family RNA binding protein 1

decreases expression

nickel sulfate results in decreased expression of BICC1 mRNA

NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776

Bid

BH3 interacting domain death agonist

increases expression

nickel sulfate results in increased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

Bin1

bridging integrator 1

increases expression

nickel sulfate results in increased expression of BIN1 mRNA

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

Birc2

baculoviral IAP repeat-containing 2

increases expression

nickel sulfate results in increased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

Birc3

baculoviral IAP repeat-containing 3

increases expression

nickel sulfate results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

Birc5

baculoviral IAP repeat-containing 5

multiple interactions

nickel sulfate affects the localization of and results in increased expression of BIRC5 protein

PMID:21776270

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

Bmi1

BMI1 proto-oncogene, polycomb ring finger

decreases expression

nickel sulfate results in decreased expression of BMI1 mRNA

NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690

Bmp2

bone morphogenetic protein 2

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

Bmp4

bone morphogenetic protein 4

increases expression

nickel sulfate results in increased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

Bmp6

bone morphogenetic protein 6

increases expression

nickel sulfate results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

Bmper

BMP-binding endothelial regulator

decreases expression

nickel sulfate results in decreased expression of BMPER mRNA

NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256

Bnip3

BCL2 interacting protein 3

increases expression

nickel sulfate results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

Brcc3

BRCA1/BRCA2-containing complex subunit 3

decreases expression

nickel sulfate results in decreased expression of BRCC3 mRNA

NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080

Brd2

bromodomain containing 2

decreases expression

nickel sulfate results in decreased expression of BRD2 mRNA

NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388

Bst2

bone marrow stromal cell antigen 2

increases expression

nickel sulfate results in increased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

Btbd2

BTB domain containing 2

increases expression

nickel sulfate results in increased expression of BTBD2 mRNA

NCBI chr 7:9,058,609...9,075,341
Ensembl chr 7:9,060,788...9,075,344

Btbd3

BTB domain containing 3

decreases expression

nickel sulfate results in decreased expression of BTBD3 mRNA

NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038

Btg1

BTG anti-proliferation factor 1

increases expression

nickel sulfate results in increased expression of BTG1 mRNA

PMID:16780908 PMID:17374397 PMID:22714537

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

Bub1

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

nickel sulfate results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

C17h10orf67

similar to human chromosome 10 open reading frame 67

decreases expression

nickel sulfate results in decreased expression of C10ORF67 mRNA

NCBI chr17:82,062,461...82,174,401
Ensembl chr17:82,071,838...82,174,353

C19h1orf198

similar to human chromosome 1 open reading frame 198

increases expression

nickel sulfate results in increased expression of C1ORF198 mRNA

NCBI chr19:52,604,060...52,629,436
Ensembl chr19:52,604,060...52,629,436

C1h19orf33

similar to human chromosome 19 open reading frame 33

decreases expression

nickel sulfate results in decreased expression of C19ORF33 mRNA

NCBI chr 1:84,549,830...84,550,666
Ensembl chr 1:84,549,831...84,550,664

C1qa

complement C1q A chain

decreases expression

nickel sulfate results in decreased expression of C1QA mRNA

PMID:25673294

NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534

C1qb

complement C1q B chain

decreases expression

nickel sulfate results in decreased expression of C1QB mRNA

NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407

C1qc

complement C1q C chain

decreases expression

nickel sulfate results in decreased expression of C1QC mRNA

NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017

C1ql4

complement C1q like 4

increases expression

nickel sulfate results in increased expression of C1QL4 mRNA

NCBI chr 7:130,243,606...130,246,678
Ensembl chr 7:130,243,606...130,246,678

C1r

complement C1r

increases expression

nickel sulfate results in increased expression of C1R mRNA

NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484

C1s

complement C1s

increases expression

nickel sulfate results in increased expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

C3h15orf48

similar to human chromosome 15 open reading frame 48

increases expression

nickel sulfate results in increased expression of C15ORF48 mRNA

PMID:25673294

NCBI chr 3:109,719,952...109,723,505
Ensembl chr 3:109,719,897...109,724,006
Ensembl chr 3:109,719,897...109,724,006

complement C5

affects expression
decreases expression

nickel sulfate affects the expression of HC mRNA
nickel sulfate results in decreased expression of HC mRNA

PMID:12718980 PMID:16166746

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

C9h6orf132

similar to human chromosome 6 open reading frame 132

decreases expression

nickel sulfate results in decreased expression of C6ORF132 mRNA

NCBI chr 9:13,524,822...13,561,756
Ensembl chr 9:13,525,395...13,561,585

Cables1

Cdk5 and Abl enzyme substrate 1

increases expression

nickel sulfate results in increased expression of CABLES1 mRNA

NCBI chr18:3,076,556...3,181,181
Ensembl chr18:3,075,524...3,181,181

Cachd1

cache domain containing 1

increases expression

nickel sulfate results in increased expression of CACHD1 mRNA

NCBI chr 5:115,411,833...115,637,312
Ensembl chr 5:115,411,071...115,657,505

Cacna1i

calcium voltage-gated channel subunit alpha1 I

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of CACNA1I mRNA

NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688

Calcrl

calcitonin receptor like receptor

increases expression

nickel sulfate results in increased expression of CALCRL mRNA

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

Camk1

calcium/calmodulin-dependent protein kinase I

increases expression

nickel sulfate results in increased expression of CAMK1 mRNA

NCBI chr 4:146,481,196...146,492,039
Ensembl chr 4:146,481,196...146,492,081

Canx

calnexin

decreases expression

nickel sulfate results in decreased expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

Caprin2

caprin family member 2

increases expression

nickel sulfate results in increased expression of CAPRIN2 mRNA

NCBI chr 4:181,806,105...181,860,754
Ensembl chr 4:181,806,575...181,860,830

Car13

carbonic anhydrase 13

decreases expression

nickel sulfate results in decreased expression of CA13 mRNA

NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525

Car2

carbonic anhydrase 2

decreases expression

nickel sulfate results in decreased expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

Car9

carbonic anhydrase 9

multiple interactions
decreases expression
increases expression

Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of CA9 protein]
nickel sulfate results in decreased expression of CA9 mRNA

PMID:16288478 PMID:22714537

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

Card10

caspase recruitment domain family, member 10

increases expression

nickel sulfate results in increased expression of CARD10 mRNA

NCBI chr 7:110,330,460...110,371,551
Ensembl chr 7:110,330,408...110,359,224

Carmil1

capping protein regulator and myosin 1 linker 1

increases expression

nickel sulfate results in increased expression of CARMIL1 mRNA

NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326

Cask

calcium/calmodulin dependent serine protein kinase

decreases expression

nickel sulfate results in decreased expression of CASK mRNA

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

Casp12

caspase 12

increases expression
multiple interactions

nickel sulfate results in increased expression of CASP12 mRNA; nickel sulfate results in increased expression of CASP12 protein
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP12 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]

PMID:28296042 PMID:34612572

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

Casp3

caspase 3

multiple interactions
increases cleavage
increases expression
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]]; nickel sulfate inhibits the reaction [Potassium Dichromate results in increased cleavage of and results in increased activity of CASP3 protein]; nickel sulfate results in increased cleavage of and results in increased activity of CASP3 protein; nickel sulfate results in increased expression of and results in increased cleavage of CASP3 protein; Potassium Dichromate inhibits the reaction [nickel sulfate results in increased cleavage of and results in increased activity of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in decreased expression of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]
nickel sulfate results in increased cleavage of CASP3 protein
sesamin inhibits the reaction [nickel sulfate results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]
nickel sulfate results in increased expression of CASP3 protein; nickel sulfate results in increased expression of CASP3 protein modified form
nickel sulfate results in increased expression of CASP3 mRNA; nickel sulfate results in increased expression of CASP3 protein modified form

PMID:20493934 PMID:23317420 PMID:28296042 PMID:34612572 PMID:35499276

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp9

caspase 9

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP9 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]
nickel sulfate results in increased expression of CASP9 mRNA; nickel sulfate results in increased expression of CASP9 protein

PMID:28296042 PMID:34612572

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

Cat

catalase

increases expression
multiple interactions
decreases activity
increases activity

nickel sulfate results in increased expression of CAT mRNA
naringin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]; Selenium inhibits the reaction [nickel sulfate results in increased activity of CAT protein]; Zinc inhibits the reaction [nickel sulfate results in increased activity of CAT protein]
sesamin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]

PMID:15535990 PMID:20566472 PMID:20950607 PMID:23317420 PMID:34612572

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Cblb

Cbl proto-oncogene B

increases expression

nickel sulfate results in increased expression of CBLB mRNA

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

Cbr2

carbonyl reductase 2

decreases expression

nickel sulfate results in decreased expression of CBR2 mRNA

NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001

Cbx2

chromobox 2

increases expression

nickel sulfate results in increased expression of CBX2 mRNA

NCBI chr10:104,278,517...104,287,384
Ensembl chr10:104,278,549...104,287,383

Ccdc167

coiled-coil domain containing 167

increases expression

nickel sulfate results in increased expression of CCDC167 mRNA

NCBI chr20:7,763,927...7,782,090
Ensembl chr20:7,751,782...7,781,613

Ccdc169

coiled-coil domain containing 169

decreases expression

nickel sulfate results in decreased expression of CCDC169 mRNA

NCBI chr 2:139,321,644...139,351,161
Ensembl chr 2:139,321,670...139,351,161

Ccdc18

coiled-coil domain containing 18

decreases expression

nickel sulfate results in decreased expression of CCDC18 mRNA

NCBI chr14:1,501,749...1,607,672
Ensembl chr14:1,501,784...1,607,711

Ccdc3

coiled-coil domain containing 3

increases expression

nickel sulfate results in increased expression of CCDC3 mRNA

NCBI chr17:73,031,891...73,135,173
Ensembl chr17:73,035,045...73,135,337

Ccdc68

coiled-coil domain containing 68

increases expression

nickel sulfate results in increased expression of CCDC68 mRNA

NCBI chr18:63,541,828...63,584,122
Ensembl chr18:63,541,896...63,584,119

Ccdc80

coiled-coil domain containing 80

decreases expression

nickel sulfate results in decreased expression of CCDC80 mRNA

NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137

Ccdc88c

coiled-coil domain containing 88C

increases expression

nickel sulfate results in increased expression of CCDC88C mRNA

NCBI chr 6:120,169,752...120,289,459
Ensembl chr 6:120,169,738...120,289,555

Ccl1

C-C motif chemokine ligand 1

increases expression

nickel sulfate results in increased expression of CCL1 mRNA

PMID:11145678

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

Ccl11

C-C motif chemokine ligand 11

decreases expression
increases expression
affects expression

nickel sulfate results in decreased expression of CCL11 mRNA
nickel sulfate results in increased expression of CCL11 mRNA
nickel sulfate affects the expression of CCL11 mRNA

PMID:16166746 PMID:18202158 PMID:18832182

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

Ccl12

C-C motif chemokine ligand 12

decreases expression

nickel sulfate results in decreased expression of CCL13 mRNA

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

Ccl17

C-C motif chemokine ligand 17

affects expression
increases expression

nickel sulfate affects the expression of CCL17 mRNA
nickel sulfate results in increased expression of CCL17 mRNA

PMID:16166746 PMID:18202158

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

Ccl2

C-C motif chemokine ligand 2

decreases expression
increases expression
multiple interactions

nickel sulfate results in decreased expression of CCL2 mRNA
nickel sulfate results in increased expression of CCL2 mRNA
[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of CCL2 mRNA

PMID:12060402 PMID:15585374 PMID:16100012 PMID:16166746 PMID:16780908 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Ccl20

C-C motif chemokine ligand 20

multiple interactions
increases secretion

IL1A protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]; TNF protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]

PMID:15679580 PMID:16099135

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

Ccl22

C-C motif chemokine ligand 22

affects expression
increases expression

nickel sulfate affects the expression of CCL22 mRNA
nickel sulfate results in increased expression of CCL22 mRNA

PMID:12060402 PMID:16166746 PMID:18202158

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

Ccl27

C-C motif chemokine ligand 27

increases secretion

nickel sulfate results in increased secretion of CCL27 protein

PMID:15679580

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

Ccl28

C-C motif chemokine ligand 28

decreases expression

nickel sulfate results in decreased expression of CCL28 mRNA

NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997

Ccl3

C-C motif chemokine ligand 3

affects expression
increases expression

nickel sulfate affects the expression of CCL3 mRNA
nickel sulfate results in increased expression of CCL3 mRNA

PMID:15585374 PMID:16780908 PMID:18202158 PMID:19732821

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

Ccl4

C-C motif chemokine ligand 4

increases expression
increases secretion

nickel sulfate results in increased expression of CCL4 mRNA; nickel sulfate results in increased expression of CCL4 protein
nickel sulfate results in increased secretion of CCL4 protein

PMID:12060402 PMID:15585374 PMID:16314067 PMID:16780908 PMID:18353026 More...

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

Ccl5

C-C motif chemokine ligand 5

affects expression
increases secretion

nickel sulfate affects the expression of CCL5 mRNA
nickel sulfate results in increased secretion of CCL5 protein

PMID:16099135 PMID:18202158

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

Ccl7

C-C motif chemokine ligand 7

increases expression

nickel sulfate results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

Ccr1

C-C motif chemokine receptor 1

affects expression

nickel sulfate affects the expression of CCR1 mRNA

NCBI chr 8:123,556,286...123,561,841

Ccr2

C-C motif chemokine receptor 2

decreases expression

nickel sulfate results in decreased expression of CCR2 mRNA

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

Ccr6

C-C motif chemokine receptor 6

decreases expression

nickel sulfate results in decreased expression of CCR6 protein

PMID:15924226

NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603

Ccr7

C-C motif chemokine receptor 7

affects expression
increases expression

nickel sulfate affects the expression of CCR7 mRNA
nickel sulfate results in increased expression of CCR7 mRNA

PMID:15304089 PMID:16780908 PMID:17374397 PMID:18202158 PMID:21697260

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

Ccr8

C-C motif chemokine receptor 8

affects expression
increases expression

nickel sulfate affects the expression of CCR8 mRNA
nickel sulfate results in increased expression of CCR8 mRNA

PMID:11145678 PMID:18202158

NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629

Cd200

Cd200 molecule

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CD200 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of CD200 mRNA

PMID:22714537 PMID:31734292

NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648

Cd207

CD207 molecule

multiple interactions
decreases expression

pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CD207 protein]

PMID:15588916

NCBI chr 4:116,155,229...116,161,587
Ensembl chr 4:116,155,212...116,161,518

Cd274

CD274 molecule

increases expression
decreases expression

nickel sulfate results in increased expression of CD274 protein
nickel sulfate results in decreased expression of CD274 mRNA

PMID:22714537 PMID:25673294

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

Cd276

Cd276 molecule

increases expression

nickel sulfate results in increased expression of CD276 mRNA

NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380

Cd36

CD36 molecule

decreases expression

nickel sulfate results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

Cd40

CD40 molecule

multiple interactions
increases expression

BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD40 protein]

PMID:17636246 PMID:25673294

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

Cd68

Cd68 molecule

increases expression

nickel sulfate results in increased expression of CD68 mRNA

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

Cd69

Cd69 molecule

increases expression

nickel sulfate results in increased expression of CD69 mRNA

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

Cd74

CD74 molecule

decreases expression

nickel sulfate results in decreased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

Cd79a

CD79a molecule

decreases expression

nickel sulfate results in decreased expression of CD79A mRNA

NCBI chr 1:80,493,581...80,497,936
Ensembl chr 1:80,493,581...80,497,935

Cd80

Cd80 molecule

increases expression

nickel sulfate results in increased expression of CD80 protein

PMID:25673294

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

Cd82

Cd82 molecule

increases expression

nickel sulfate results in increased expression of CD82 mRNA

NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809

Cd83

CD83 molecule

increases expression
multiple interactions

nickel sulfate results in increased expression of CD83 mRNA; nickel sulfate results in increased expression of CD83 protein
BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD83 protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [nickel sulfate results in increased expression of CD83 protein]; TNF protein promotes the reaction [nickel sulfate results in increased expression of CD83 protein]

PMID:16099135 PMID:16780908 PMID:17636246 PMID:21697260 PMID:25673294

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

Cd86

CD86 molecule

increases expression
affects expression
multiple interactions

nickel sulfate results in increased expression of CD86 mRNA; nickel sulfate results in increased expression of CD86 protein
nickel sulfate affects the expression of CD86 mRNA
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]

PMID:16099135 PMID:16780908 PMID:17374397 PMID:17636246 PMID:18202158 More...

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

Cd8a

CD8 subunit alpha

increases expression

nickel sulfate results in increased expression of CD8A mRNA

NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040

Cd99

CD99 molecule (Xg blood group)

increases expression

nickel sulfate results in increased expression of CD99 mRNA

NCBI chr20:54,418,239...54,422,882

Cdc25b

cell division cycle 25B

decreases expression

nickel sulfate results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

Cdc34

cell division cycle 34, ubiqiutin conjugating enzyme

increases expression

nickel sulfate results in increased expression of CDC34 mRNA

NCBI chr 7:10,017,588...10,023,586
Ensembl chr 7:10,017,588...10,023,186

Cdh1

cadherin 1

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CDH1 mRNA; nickel sulfate results in decreased expression of CDH1 protein
pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CDH1 protein]

PMID:15588916 PMID:16780908 PMID:22648416

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

Cdh13

cadherin 13

decreases expression

nickel sulfate results in decreased expression of CDH13 mRNA

NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459

Cdh16

cadherin 16

decreases expression

nickel sulfate results in decreased expression of CDH16 mRNA

NCBI chr19:360,824...371,008
Ensembl chr19:360,824...371,007

Cdh3

cadherin 3

decreases expression

nickel sulfate results in decreased expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

Cdh8

cadherin 8

decreases expression

nickel sulfate results in decreased expression of CDH8 mRNA

NCBI chr19:5,494,038...5,901,810
Ensembl chr19:5,494,174...5,895,669

Cdk10

cyclin-dependent kinase 10

increases expression

nickel sulfate results in increased expression of CDK10 mRNA

NCBI chr19:51,260,012...51,273,009
Ensembl chr19:51,261,356...51,269,078

Cdk14

cyclin-dependent kinase 14

decreases expression

nickel sulfate results in decreased expression of CDK14 mRNA

NCBI chr 4:28,666,416...29,258,865
Ensembl chr 4:28,666,843...29,258,861

Cdk6

cyclin-dependent kinase 6

decreases expression

nickel sulfate results in decreased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

Cdkl2

cyclin dependent kinase like 2

increases expression

nickel sulfate results in increased expression of CDKL2 mRNA

NCBI chr14:16,027,381...16,063,257
Ensembl chr14:16,028,363...16,063,252

Cdkl5

cyclin-dependent kinase-like 5

decreases expression

nickel sulfate results in decreased expression of CDKL5 mRNA

NCBI chr X:33,757,605...33,988,075
Ensembl chr X:33,821,257...33,986,582

Cdkn1a

cyclin-dependent kinase inhibitor 1A

increases expression

nickel sulfate results in increased expression of CDKN1A mRNA

PMID:16100012 PMID:16166746 PMID:16314067

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Cdkn2d

cyclin dependent kinase inhibitor 2D

increases expression

nickel sulfate results in increased expression of CDKN2D mRNA

NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674

Cdo1

cysteine dioxygenase type 1

decreases expression

nickel sulfate results in decreased expression of CDO1 mRNA

NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296

Cds2

CDP-diacylglycerol synthase 2

decreases expression

nickel sulfate results in decreased expression of CDS2 mRNA

NCBI chr 3:119,514,963...119,553,555
Ensembl chr 3:119,515,000...119,553,541

Cdt1

chromatin licensing and DNA replication factor 1

increases expression

nickel sulfate results in increased expression of CDT1 mRNA

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

Cept1

choline/ethanolamine phosphotransferase 1

decreases expression

nickel sulfate results in decreased expression of CEPT1 mRNA

NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578

Cerkl

CERK like autophagy regulator

decreases expression

nickel sulfate results in decreased expression of CERKL mRNA

NCBI chr 3:64,238,714...64,344,695
Ensembl chr 3:64,237,522...64,340,675

Cers6

ceramide synthase 6

increases expression

nickel sulfate results in increased expression of LASS6 mRNA

NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848

Cfap119

cilia and flagella associated protein 119

increases expression

nickel sulfate results in increased expression of CFAP119 mRNA

NCBI chr 1:182,197,171...182,216,936
Ensembl chr 1:182,192,947...182,202,338

Cfap251

cilia and flagella associated protein 251

decreases expression

nickel sulfate results in decreased expression of CFAP251 mRNA

NCBI chr12:33,261,622...33,337,028
Ensembl chr12:33,261,476...33,293,932

Cfap44

cilia and flagella associated protein 44

decreases expression

nickel sulfate results in decreased expression of CFAP44 mRNA

NCBI chr11:56,199,772...56,283,964
Ensembl chr11:56,201,049...56,283,986

Cfap69

cilia and flagella associated protein 69

increases expression

nickel sulfate results in increased expression of CFAP69 mRNA

NCBI chr 4:28,379,604...28,452,562
Ensembl chr 4:28,375,996...28,450,698

Cflar

CASP8 and FADD-like apoptosis regulator

increases expression

nickel sulfate results in increased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

Cga

glycoprotein hormones, alpha polypeptide

increases expression
multiple interactions

nickel sulfate results in increased expression of CGA mRNA
[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 protein; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 protein; [CGA protein co-treated with nickel sulfate] results in decreased expression of HSD17B3 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of STAR mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of STAR protein

PMID:18651567 PMID:29567110

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

Chd1l

chromodomain helicase DNA binding protein 1-like

decreases expression

nickel sulfate results in decreased expression of CHD1L mRNA

NCBI chr 2:185,138,526...185,217,498
Ensembl chr 2:185,139,308...185,217,595

Chka

choline kinase alpha

increases expression

nickel sulfate results in increased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

Chmp1a

charged multivesicular body protein 1A

increases expression

nickel sulfate results in increased expression of CHMP1A mRNA

NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436

Chrdl1

chordin-like 1

decreases expression

nickel sulfate results in decreased expression of CHRDL1 mRNA

NCBI chr X:106,889,125...106,992,937
Ensembl chr X:106,889,125...106,992,921

Chst11

carbohydrate sulfotransferase 11

decreases expression

nickel sulfate results in decreased expression of CHST11 mRNA

NCBI chr 7:20,524,535...20,743,008
Ensembl chr 7:20,528,100...20,743,111

Chst15

carbohydrate sulfotransferase 15

decreases expression

nickel sulfate results in decreased expression of CHST15 mRNA

NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707

Cidea

cell death-inducing DFFA-like effector a

multiple interactions
decreases expression

[nickel sulfate co-treated with Particulate Matter] results in decreased expression of CIDEA mRNA
nickel sulfate results in decreased expression of CIDEA mRNA

PMID:23126276

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

Cidec

cell death-inducing DFFA-like effector c

increases expression

nickel sulfate results in increased expression of CIDEC mRNA

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

Cisd1

CDGSH iron sulfur domain 1

decreases expression

nickel sulfate results in decreased expression of CISD1 mRNA

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

Cited2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression

nickel sulfate results in decreased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

Ckb

creatine kinase B

decreases expression

nickel sulfate results in decreased expression of CKB mRNA

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

Clcn4

chloride voltage-gated channel 4

increases expression

nickel sulfate results in increased expression of CLCN4 mRNA

NCBI chr X:23,729,194...23,795,391
Ensembl chr X:23,729,338...23,793,238

Cldn11

claudin 11

increases expression

nickel sulfate results in increased expression of CLDN11 mRNA

NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050

Clic4

chloride intracellular channel 4

increases expression

nickel sulfate results in increased expression of CLIC4 mRNA

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

Clip2

CAP-GLY domain containing linker protein 2

increases expression

nickel sulfate results in increased expression of CLIP2 mRNA

NCBI chr12:22,163,044...22,227,023
Ensembl chr12:22,163,218...22,227,023

Cltb

clathrin, light chain B

decreases expression
increases expression

nickel sulfate results in decreased expression of CLTB mRNA
nickel sulfate results in increased expression of CLTB mRNA

NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169

Cmbl

carboxymethylenebutenolidase homolog

increases expression

nickel sulfate results in increased expression of CMBL mRNA

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009

Cmip

c-Maf-inducing protein

increases expression

nickel sulfate results in increased expression of CMIP mRNA

NCBI chr19:45,304,597...45,510,653
Ensembl chr19:45,304,031...45,508,709

Cmpk2

cytidine/uridine monophosphate kinase 2

decreases expression

nickel sulfate results in decreased expression of CMPK2 mRNA

NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183

Cnn1

calponin 1

decreases expression

nickel sulfate results in decreased expression of CNN1 mRNA

NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098

Cnnm1

cyclin and CBS domain divalent metal cation transport mediator 1

decreases expression

nickel sulfate results in decreased expression of CNNM1 mRNA

NCBI chr 1:242,296,367...242,354,957
Ensembl chr 1:242,296,422...242,353,513

Cntnap1

contactin associated protein 1

decreases expression

nickel sulfate results in decreased expression of CNTNAP1 mRNA

NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611

Cntnap3

contactin associated protein family member 3

increases expression

nickel sulfate results in increased expression of CNTNAP3 mRNA

NCBI chr17:267,379...455,478
Ensembl chr17:267,508...454,102

Coch

cochlin

decreases expression

nickel sulfate results in decreased expression of COCH mRNA

NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109

Col12a1

collagen type XII alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

Col15a1

collagen type XV alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL15A1 mRNA

NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591

Col16a1

collagen type XVI alpha 1 chain

increases expression

nickel sulfate results in increased expression of COL16A1 mRNA

NCBI chr 5:142,388,376...142,442,825
Ensembl chr 5:142,388,426...142,442,825

Col1a1

collagen type I alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

Col3a1

collagen type III alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

Col4a1

collagen type IV alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

Col4a4

collagen type IV alpha 4 chain

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of COL4A4 mRNA

NCBI chr 9:83,833,173...83,875,436
Ensembl chr 9:83,755,515...83,875,876

Col4a5

collagen type IV alpha 5 chain

decreases expression

nickel sulfate results in decreased expression of COL4A5 mRNA

NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692

Col5a1

collagen type V alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

Col5a2

collagen type V alpha 2 chain

increases expression

nickel sulfate results in increased expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

Col6a3

collagen type VI alpha 3 chain

decreases expression

nickel sulfate results in decreased expression of COL6A3 mRNA

NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471

Col8a1

collagen type VIII alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL8A1 mRNA

NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424

Commd3

COMM domain containing 3

decreases expression

nickel sulfate results in decreased expression of COMMD3 mRNA

NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177

Comt

catechol-O-methyltransferase

increases expression

nickel sulfate results in increased expression of COMT mRNA

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

Coro2b

coronin 2B

decreases expression

nickel sulfate results in decreased expression of CORO2B mRNA

NCBI chr 8:62,906,861...63,017,295
Ensembl chr 8:62,906,867...63,017,302

Cpe

carboxypeptidase E

decreases expression

nickel sulfate results in decreased expression of CPE mRNA

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

Cpeb3

cytoplasmic polyadenylation element binding protein 3

decreases expression

nickel sulfate results in decreased expression of CPEB3 mRNA

NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560

Cpne3

copine 3

decreases expression

nickel sulfate results in decreased expression of CPNE3 mRNA

NCBI chr 5:33,014,658...33,063,934
Ensembl chr 5:33,016,307...33,063,934

Cpped1

calcineurin-like phosphoesterase domain containing 1

increases expression

nickel sulfate results in increased expression of CPPED1 mRNA

NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054

Cpq

carboxypeptidase Q

increases expression

nickel sulfate results in increased expression of PGCP mRNA

NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546

Cpt1c

carnitine palmitoyltransferase 1c

decreases expression

nickel sulfate results in decreased expression of CPT1C mRNA

NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342

Cpvl

carboxypeptidase, vitellogenic-like

increases expression

nickel sulfate results in increased expression of CPVL mRNA

NCBI chr 4:82,981,421...83,091,730
Ensembl chr 4:82,981,422...83,085,655

Crabp2

cellular retinoic acid binding protein 2

decreases expression

nickel sulfate results in decreased expression of CRABP2 mRNA

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

Creb1

cAMP responsive element binding protein 1

affects expression
multiple interactions
increases phosphorylation

nickel sulfate affects the expression of CREB1 mRNA
puerarin inhibits the reaction [nickel sulfate results in increased phosphorylation of CREB1 protein]
[nickel sulfate co-treated with Dinoprostone] results in increased expression of CREB1 protein; CREB1 protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]

PMID:20385217 PMID:23526216 PMID:26607348

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

Creb5

cAMP responsive element binding protein 5

decreases expression

nickel sulfate results in decreased expression of CREB5 mRNA

NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325

Crem

cAMP responsive element modulator

increases expression

nickel sulfate results in increased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

Crim1

cysteine rich transmembrane BMP regulator 1

increases expression

nickel sulfate results in increased expression of CRIM1 mRNA

NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259

Crls1

cardiolipin synthase 1

decreases expression

nickel sulfate results in decreased expression of CRLS1 mRNA

NCBI chr 3:120,119,822...120,138,674
Ensembl chr 3:120,119,852...120,138,655

Crnkl1

crooked neck pre-mRNA splicing factor 1

decreases expression

nickel sulfate results in decreased expression of CRNKL1 mRNA

NCBI chr 3:133,338,593...133,354,329
Ensembl chr 3:133,337,039...133,354,302
Ensembl chr 6:133,337,039...133,354,302

Crybg3

crystallin beta-gamma domain containing 3

decreases expression

nickel sulfate results in decreased expression of CRYBG3 mRNA

NCBI chr11:40,749,198...40,861,753
Ensembl chr11:40,749,214...40,861,752

Csf2rb

colony stimulating factor 2 receptor subunit beta

affects expression

nickel sulfate affects the expression of CSF2RB mRNA

NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157

Csf3r

colony stimulating factor 3 receptor

increases expression

nickel sulfate results in increased expression of CSF3R mRNA

NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881

Csnk2a1

casein kinase 2 alpha 1

decreases expression

nickel sulfate results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

Cspg4

chondroitin sulfate proteoglycan 4

decreases expression

nickel sulfate results in decreased expression of CSPG4 mRNA

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010

Csta

cystatin A

decreases expression

nickel sulfate results in decreased expression of CSTA mRNA

NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488

Cth

cystathionine gamma-lyase

decreases expression

nickel sulfate results in decreased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

Ctnnal1

catenin alpha-like 1

decreases expression

nickel sulfate results in decreased expression of CTNNAL1 mRNA

NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431

Ctps1

CTP synthase 1

increases expression

nickel sulfate results in increased expression of CTPS1 mRNA

NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180

Ctsb

cathepsin B

increases expression

nickel sulfate results in increased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

Ctsc

cathepsin C

decreases expression

nickel sulfate results in decreased expression of CTSC mRNA

PMID:16780908 PMID:17374397 PMID:22714537 PMID:25673294

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

Ctsf

cathepsin F

decreases expression

nickel sulfate results in decreased expression of CTSF mRNA

NCBI chr 1:202,152,777...202,158,525
Ensembl chr 1:202,152,728...202,158,525

Ctsl

cathepsin L

increases expression
decreases expression

nickel sulfate results in increased expression of CTSL mRNA
nickel sulfate results in decreased expression of CTSL mRNA

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

Cul4b

cullin 4B

decreases expression

nickel sulfate results in decreased expression of CUL4B mRNA

NCBI chr X:117,287,481...117,326,688
Ensembl chr X:117,287,484...117,326,688

Cxadr

CXADR, Ig-like cell adhesion molecule

decreases expression

nickel sulfate results in decreased expression of CXADR mRNA

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

Cxcl1

C-X-C motif chemokine ligand 1

multiple interactions
increases expression

HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL1 protein]; macrophage stimulatory lipopeptide 2 promotes the reaction [nickel sulfate results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL1 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL1 protein]

PMID:16780908 PMID:18832182

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

Cxcl10

C-X-C motif chemokine ligand 10

increases expression
decreases expression
multiple interactions

nickel sulfate results in increased expression of CXCL10 mRNA
nickel sulfate results in decreased expression of CXCL10 mRNA
[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of CXCL10 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [nickel sulfate inhibits the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL10 protein]]; nickel sulfate inhibits the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL10 mRNA]; nickel sulfate inhibits the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL10 protein]

PMID:12060402 PMID:18096868 PMID:18832182 PMID:23445166

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

Cxcl16

C-X-C motif chemokine ligand 16

increases expression

nickel sulfate results in increased expression of CXCL16 mRNA

NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592

Cxcl2

C-X-C motif chemokine ligand 2

affects expression
increases expression

nickel sulfate affects the expression of CXCL2 mRNA
nickel sulfate results in increased expression of CXCL2 mRNA

PMID:11708899 PMID:18202158

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

Cxcl3

C-X-C motif chemokine ligand 3

multiple interactions
increases expression

PMID:16166746 PMID:16780908 PMID:18832182

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

Cxcl6

C-X-C motif chemokine ligand 6

multiple interactions

nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL6 mRNA]

PMID:18832182

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

Cxcr4

C-X-C motif chemokine receptor 4

decreases expression
increases expression
affects expression

nickel sulfate results in decreased expression of CXCR4 protein
nickel sulfate results in increased expression of CXCR4 mRNA
nickel sulfate affects the expression of CXCR4 mRNA

PMID:15924226 PMID:16780908 PMID:17374397 PMID:17382205 PMID:18202158

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

Cxhxorf38

similar to human chromosome X open reading frame 38

decreases expression

nickel sulfate results in decreased expression of CXORF38 mRNA

NCBI chr X:10,128,070...10,150,904
Ensembl chr X:10,129,657...10,150,900

Cyba

cytochrome b-245 alpha chain

increases expression

nickel sulfate results in increased expression of CYBA mRNA

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

Cycs

cytochrome c, somatic

increases expression
multiple interactions

nickel sulfate results in increased expression of CYCS mRNA; nickel sulfate results in increased expression of CYCS protein
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CYCS mRNA]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CYCS mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]

PMID:28296042 PMID:34612572

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

Cygb

cytoglobin

decreases expression

nickel sulfate results in decreased expression of CYGB mRNA

NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442

Cyp11a1

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CYP11A1 mRNA; nickel sulfate results in decreased expression of CYP11A1 protein
[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 protein; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]

PMID:29567110

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

Cyp17a1

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions
decreases expression

[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 protein; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]
nickel sulfate results in decreased expression of CYP17A1 mRNA; nickel sulfate results in decreased expression of CYP17A1 protein

PMID:29567110

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases expression

nickel sulfate results in increased expression of CYP1A1 mRNA
nickel sulfate results in decreased expression of CYP1A1 mRNA

PMID:20491607 PMID:20713136

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

Cyp1b1

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CYP1B1 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of CYP1B1 mRNA

PMID:22714537 PMID:31734292

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

Cyp27a1

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression
multiple interactions
increases expression

nickel sulfate results in decreased expression of CYP27A1 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of CYP27A1 mRNA
nickel sulfate results in increased expression of CYP27A1 mRNA

PMID:20713136 PMID:22714537 PMID:31734292

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

Cyp2b3

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases expression

nickel sulfate results in decreased expression of CYP2B10 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

Cyp2f4

cytochrome P450, family 2, subfamily f, polypeptide 4

affects expression
decreases expression

nickel sulfate affects the expression of CYP2F2 mRNA
nickel sulfate results in decreased expression of CYP2F2 mRNA

PMID:12718980 PMID:16100012

NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896

Cyp2u1

cytochrome P450, family 2, subfamily u, polypeptide 1

decreases expression

nickel sulfate results in decreased expression of CYP2U1 mRNA

NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882

Cytip

cytohesin 1 interacting protein

increases expression

nickel sulfate results in increased expression of CYTIP mRNA

NCBI chr 3:42,698,058...42,774,955
Ensembl chr 3:42,698,768...42,725,993

Dab1

DAB adaptor protein 1

increases expression

nickel sulfate results in increased expression of DAB1 mRNA

NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552

Dact1

dishevelled-binding antagonist of beta-catenin 1

decreases expression

nickel sulfate results in decreased expression of DACT1 mRNA

NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906

Dapk1

death associated protein kinase 1

decreases expression

nickel sulfate results in decreased expression of DAPK1 mRNA

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

Dcbld2

discoidin, CUB and LCCL domain containing 2

decreases expression

nickel sulfate results in decreased expression of DCBLD2 mRNA

NCBI chr11:42,125,525...42,179,927
Ensembl chr11:42,125,787...42,179,697

Dclk2

doublecortin-like kinase 2

increases expression

nickel sulfate results in increased expression of DCLK2 mRNA

NCBI chr 2:172,202,733...172,338,411
Ensembl chr 2:172,208,706...172,338,250

Dct

dopachrome tautomerase

increases expression

nickel sulfate results in increased expression of DCT mRNA

NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836

Dctpp1

dCTP pyrophosphatase 1

decreases expression

nickel sulfate results in decreased expression of DCTPP1 mRNA

NCBI chr 1:181,877,440...181,880,833
Ensembl chr 1:181,877,437...181,880,839

Ddah2

DDAH family member 2, ADMA-independent

increases expression

nickel sulfate results in increased expression of DDAH2 mRNA

NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511

Ddit3

DNA-damage inducible transcript 3

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of DDIT3 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of DDIT3 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of DDIT3 protein]
nickel sulfate results in increased expression of DDIT3 mRNA; nickel sulfate results in increased expression of DDIT3 protein

PMID:28296042

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

Ddit4

DNA-damage-inducible transcript 4

increases expression

nickel sulfate results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

Ddo

D-aspartate oxidase

increases expression

nickel sulfate results in increased expression of DDO mRNA

NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095

Ddr1

discoidin domain receptor tyrosine kinase 1

increases expression

nickel sulfate results in increased expression of DDR1 mRNA

NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468

Ddr2

discoidin domain receptor tyrosine kinase 2

increases expression

nickel sulfate results in increased expression of DDR2 mRNA

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

Ddrgk1

DDRGK domain containing 1

decreases expression

nickel sulfate results in decreased expression of DDRGK1 mRNA

NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680

Ddx17

DEAD-box helicase 17

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of DDX17 mRNA

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

Ddx39b

DExD-box helicase 39B

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of DDX39B mRNA

NCBI chr20:3,547,702...3,585,064
Ensembl chr20:3,572,056...3,584,996

Deaf1

DEAF1 transcription factor

increases expression

nickel sulfate results in increased expression of DEAF1 mRNA

NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541

Def8

differentially expressed in FDCP 8 homolog

increases expression

nickel sulfate results in increased expression of DEF8 mRNA

NCBI chr19:51,474,783...51,495,638
Ensembl chr19:51,474,878...51,495,638

Dennd1b

DENN domain containing 1B

increases expression

nickel sulfate results in increased expression of DENND1B mRNA

NCBI chr13:50,545,324...50,772,922
Ensembl chr13:50,545,836...50,770,601

Dennd2d

DENN domain containing 2D

decreases expression

nickel sulfate results in decreased expression of DENND2D mRNA

NCBI chr 2:193,973,231...193,992,275
Ensembl chr 2:193,973,231...193,992,270

Depp1

DEPP autophagy regulator 1

increases expression

nickel sulfate results in increased expression of DEPP1 mRNA

PMID:16780908 PMID:17382205

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

Dgka

diacylglycerol kinase, alpha

decreases expression

nickel sulfate results in decreased expression of DGKA mRNA

NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110

Dgkh

diacylglycerol kinase, eta

decreases expression

nickel sulfate results in decreased expression of DGKH mRNA

NCBI chr15:53,981,079...54,150,470
Ensembl chr15:53,991,481...54,150,706

Dgki

diacylglycerol kinase, iota

decreases expression

nickel sulfate results in decreased expression of DGKI mRNA

NCBI chr 4:65,410,878...65,872,733
Ensembl chr 4:65,420,108...65,872,733

Dhrs11

dehydrogenase/reductase 11

increases expression

nickel sulfate results in increased expression of DHRS11 mRNA

NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295

Diaph2

diaphanous-related formin 2

decreases expression

nickel sulfate results in decreased expression of DIAPH2 mRNA

NCBI chr X:92,395,189...93,234,521
Ensembl chr X:92,395,251...93,229,869

Dio2

iodothyronine deiodinase 2

increases expression

nickel sulfate results in increased expression of DIO2 mRNA

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

Dkc1

dyskerin pseudouridine synthase 1

decreases expression

nickel sulfate results in decreased expression of DKC1 mRNA

Dlx1

distal-less homeobox 1

increases expression

nickel sulfate results in increased expression of DLX1 mRNA

NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780

Dlx2

distal-less homeobox 2

increases expression

nickel sulfate results in increased expression of DLX2 mRNA

NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597

Dnaaf9

dynein axonemal assembly factor 9

decreases expression

nickel sulfate results in decreased expression of DNAAF9 mRNA

NCBI chr 3:117,918,047...118,052,641
Ensembl chr 3:117,921,620...118,052,630

Dnah11

dynein, axonemal, heavy chain 11

increases expression

nickel sulfate results in increased expression of DNAH11 mRNA

NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536

Dnah9

dynein, axonemal, heavy chain 9

decreases expression

nickel sulfate results in decreased expression of DNAH9 mRNA

NCBI chr10:50,496,174...50,864,909
Ensembl chr10:50,497,688...50,864,949

Dnaja4

DnaJ heat shock protein family (Hsp40) member A4

decreases expression

nickel sulfate results in decreased expression of DNAJA4 mRNA

NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207

Dnajb6

DnaJ heat shock protein family (Hsp40) member B6

increases expression

nickel sulfate results in increased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

Dnajc1

DnaJ heat shock protein family (Hsp40) member C1

decreases expression

nickel sulfate results in decreased expression of DNAJC1 mRNA

NCBI chr17:80,955,209...81,112,025
Ensembl chr17:80,955,237...81,111,988

Dnali1

dynein, axonemal, light intermediate chain 1

decreases expression

nickel sulfate results in decreased expression of DNALI1 mRNA

NCBI chr 5:137,318,475...137,327,313
Ensembl chr 5:137,318,477...137,327,336

Dnm3

dynamin 3

decreases expression

nickel sulfate results in decreased expression of DNM3 mRNA

NCBI chr13:74,359,043...74,838,135
Ensembl chr13:74,359,213...74,838,108

Dock10

dedicator of cytokinesis 10

increases expression

nickel sulfate results in increased expression of DOCK10 mRNA

NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525

Dock11

dedicator of cytokinesis 11

increases expression

nickel sulfate results in increased expression of DOCK11 mRNA

NCBI chr X:115,131,720...115,314,854
Ensembl chr X:115,131,909...115,314,854

Dpp4

dipeptidylpeptidase 4

decreases expression
increases expression

nickel sulfate results in decreased expression of DPP4 mRNA
nickel sulfate results in increased expression of DPP4 mRNA

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

Dpp7

dipeptidylpeptidase 7

decreases expression

nickel sulfate results in decreased expression of DPP7 mRNA

NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355

Dpy19l3

dpy-19 like C-mannosyltransferase 3

decreases expression

nickel sulfate results in decreased expression of DPY19L3 mRNA

NCBI chr 1:88,350,303...88,417,339
Ensembl chr 1:88,350,303...88,417,339

Dpyd

dihydropyrimidine dehydrogenase

decreases expression

nickel sulfate results in decreased expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

Dram1

DNA-damage regulated autophagy modulator 1

increases expression

nickel sulfate results in increased expression of DRAM1 mRNA

NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765

Dse

dermatan sulfate epimerase

decreases expression

nickel sulfate results in decreased expression of DSE mRNA

NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992

Dsel

dermatan sulfate epimerase-like

increases expression

nickel sulfate results in increased expression of DSEL mRNA

NCBI chr13:186,413...192,592
Ensembl chr13:175,805...192,647

Dsg2

desmoglein 2

increases expression

nickel sulfate results in increased expression of DSG2 mRNA

NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156

Dstn

destrin, actin depolymerizing factor

decreases expression

nickel sulfate results in decreased expression of DSTN mRNA

NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379

Dtd1

D-aminoacyl-tRNA deacylase 1

decreases expression

nickel sulfate results in decreased expression of DTD1 mRNA

NCBI chr 3:131,995,870...132,158,646
Ensembl chr 3:131,995,861...132,158,659

Dtx3

deltex E3 ubiquitin ligase 3

decreases expression

nickel sulfate results in decreased expression of DTX3 mRNA

NCBI chr 7:63,013,769...63,018,431
Ensembl chr 7:63,013,371...63,018,522

Dusp1

dual specificity phosphatase 1

increases expression

nickel sulfate results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

Dusp10

dual specificity phosphatase 10

increases expression

nickel sulfate results in increased expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

Dusp22

dual specificity phosphatase 22

increases expression

nickel sulfate results in increased expression of DUSP22 mRNA

NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321

Dusp23

dual specificity phosphatase 23

decreases expression

nickel sulfate results in decreased expression of DUSP23 mRNA

NCBI chr13:85,097,899...85,100,054
Ensembl chr13:85,097,899...85,100,093

Dusp4

dual specificity phosphatase 4

increases expression

nickel sulfate results in increased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

Dusp5

dual specificity phosphatase 5

increases expression

nickel sulfate results in increased expression of DUSP5 mRNA

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

Dync2h1

dynein cytoplasmic 2 heavy chain 1

decreases expression

nickel sulfate results in decreased expression of DYNC2H1 mRNA

NCBI chr 8:4,189,067...4,412,183
Ensembl chr 8:4,189,257...4,412,183

Dysf

dysferlin

decreases expression

nickel sulfate results in decreased expression of DYSF mRNA

NCBI chr 4:116,490,877...116,690,709
Ensembl chr 4:116,490,616...116,690,709

Ebi3

Epstein-Barr virus induced 3

increases expression
multiple interactions

nickel sulfate results in increased expression of EBI3 mRNA
BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of EBI3 mRNA]; TLR4 protein affects the reaction [nickel sulfate results in increased expression of EBI3 mRNA]

PMID:16780908 PMID:30421605

NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544

Ece1

endothelin converting enzyme 1

increases expression

nickel sulfate results in increased expression of ECE1 mRNA

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

Echdc3

enoyl CoA hydratase domain containing 3

decreases expression

nickel sulfate results in decreased expression of ECHDC3 mRNA

NCBI chr17:72,070,697...72,093,519
Ensembl chr17:72,070,668...72,093,516

Ecm1

extracellular matrix protein 1

increases expression

nickel sulfate results in increased expression of ECM1 mRNA

NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671

Edaradd

EDAR associated via death domain

increases expression

nickel sulfate results in increased expression of EDARADD mRNA

NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447

Edem3

ER degradation enhancing alpha-mannosidase like protein 3

decreases expression

nickel sulfate results in decreased expression of EDEM3 mRNA

NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523

Edil3

EGF like repeats and discoidin domains 3

decreases expression

nickel sulfate results in decreased expression of EDIL3 mRNA

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008

Edn1

endothelin 1

increases expression

nickel sulfate results in increased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

Efemp2

EGF containing fibulin extracellular matrix protein 2

decreases expression

nickel sulfate results in decreased expression of EFEMP2 mRNA

NCBI chr 1:202,781,692...202,789,784
Ensembl chr 1:202,781,665...202,789,414

Efhc1

EF-hand domain containing 1

increases expression

nickel sulfate results in increased expression of EFHC1 mRNA

NCBI chr 9:23,375,815...23,414,283
Ensembl chr 9:23,375,840...23,414,283

Efna1

ephrin A1

multiple interactions
increases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of EFNA1 mRNA
nickel sulfate results in increased expression of EFNA1 mRNA

PMID:18651567 PMID:18832182

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

Efna3

ephrin A3

increases expression
multiple interactions

nickel sulfate results in increased expression of EFNA3 mRNA
[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of EFNA3 mRNA

PMID:18832182

NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736

Efna5

ephrin A5

decreases expression

nickel sulfate results in decreased expression of EFNA5 mRNA

NCBI chr 9:102,316,753...102,595,480
Ensembl chr 9:102,320,295...102,597,413

Egfr

epidermal growth factor receptor

multiple interactions

[TGFA protein binds to and affects the activity of EGFR protein] which results in decreased susceptibility to nickel sulfate

PMID:19131640

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

Egr1

early growth response 1

increases expression

nickel sulfate results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

Ehhadh

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

increases expression

nickel sulfate results in increased expression of EHHADH mRNA

PMID:17374397 PMID:22714537

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

Ehmt2

euchromatic histone lysine methyltransferase 2

increases expression

nickel sulfate results in increased expression of EHMT2 mRNA

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

Ei24

EI24, autophagy associated transmembrane protein

decreases expression

nickel sulfate results in decreased expression of EI24 mRNA

NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571

Eif1ax

eukaryotic translation initiation factor 1A, X-linked

decreases expression

nickel sulfate results in decreased expression of EIF1A mRNA

NCBI chr X:35,498,698...35,513,402
Ensembl chr X:35,498,517...35,513,335

Eif4g1

eukaryotic translation initiation factor 4 gamma 1

increases expression

nickel sulfate results in increased expression of EIF4G1 mRNA

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

Eln

elastin

increases expression

nickel sulfate results in increased expression of ELN mRNA

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

Elovl2

ELOVL fatty acid elongase 2

increases expression

nickel sulfate results in increased expression of ELOVL2 mRNA

NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848

Elovl3

ELOVL fatty acid elongase 3

multiple interactions

[nickel sulfate co-treated with Particulate Matter] results in decreased expression of ELOVL3 mRNA

PMID:23126276

NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115

Elovl7

ELOVL fatty acid elongase 7

increases expression

nickel sulfate results in increased expression of ELOVL7 mRNA

NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845

Emb

embigin

decreases expression

nickel sulfate results in decreased expression of EMB mRNA

NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050

Emc8

ER membrane protein complex subunit 8

increases expression

nickel sulfate results in increased expression of EMC8 mRNA

NCBI chr19:48,708,304...48,721,626
Ensembl chr19:48,582,574...48,721,543

Eml1

EMAP like 1

increases expression

nickel sulfate results in increased expression of EML1 mRNA

NCBI chr 6:127,283,968...127,457,246
Ensembl chr 6:127,284,029...127,457,246

Emp1

epithelial membrane protein 1

decreases expression

nickel sulfate results in decreased expression of EMP1 mRNA

NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904

Enc1

ectodermal-neural cortex 1

decreases expression

nickel sulfate results in decreased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

Endod1

endonuclease domain containing 1

decreases expression

nickel sulfate results in decreased expression of ENDOD1 mRNA

NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:11,211,110...11,238,892

Eno1

enolase 1

increases expression

nickel sulfate results in increased expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

Eno2

enolase 2

increases expression

nickel sulfate results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

Eno3

enolase 3

affects expression

nickel sulfate affects the expression of ENO3 mRNA

PMID:12718980

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

Enpp1

ectonucleotide pyrophosphatase/phosphodiesterase 1

increases expression

nickel sulfate results in increased expression of ENPP1 mRNA

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

Enpp4

ectonucleotide pyrophosphatase/phosphodiesterase 4

decreases expression

nickel sulfate results in decreased expression of ENPP4 mRNA

NCBI chr 9:16,888,923...16,898,860
Ensembl chr 9:16,887,739...16,898,860

Entpd1

ectonucleoside triphosphate diphosphohydrolase 1

increases expression

nickel sulfate results in increased expression of ENTPD1 mRNA

NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317

Entpd6

ectonucleoside triphosphate diphosphohydrolase 6

decreases expression

nickel sulfate results in decreased expression of ENTPD6 mRNA

NCBI chr 3:139,575,659...139,598,163
Ensembl chr 3:139,575,686...139,598,154

Epas1

endothelial PAS domain protein 1

multiple interactions
increases expression
increases stability

[HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in decreased expression of USP28 protein]; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in increased degradation of MYC protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of EPAS1 protein]
nickel sulfate results in increased expression of EPAS1 mRNA; nickel sulfate results in increased expression of EPAS1 protein
nickel sulfate results in increased stability of EPAS1 protein

PMID:16288478 PMID:20046830 PMID:22714537

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

Epcam

epithelial cell adhesion molecule

decreases expression

nickel sulfate results in decreased expression of EPCAM mRNA

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

Epdr1

ependymin related 1

increases expression

nickel sulfate results in increased expression of EPDR1 mRNA

NCBI chr17:45,333,932...45,358,597
Ensembl chr17:45,333,956...45,358,594

Epha4

Eph receptor A4

increases expression

nickel sulfate results in increased expression of EPHA4 mRNA

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

Ephb6

Eph receptor B6

increases expression

nickel sulfate results in increased expression of EPHB6 mRNA

NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230

Epm2aip1

EPM2A interacting protein 1

decreases expression

nickel sulfate results in decreased expression of EPM2AIP1 mRNA

NCBI chr 8:111,233,871...111,241,219
Ensembl chr 8:111,233,826...111,241,871

Erbb3

erb-b2 receptor tyrosine kinase 3

decreases expression

nickel sulfate results in decreased expression of ERBB3 mRNA

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

Esd

esterase D

increases expression

nickel sulfate results in increased expression of ESD mRNA

NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144

Esf1

ESF1 nucleolar pre-rRNA processing protein homolog

decreases expression

nickel sulfate results in decreased expression of ESF1 mRNA

NCBI chr 3:127,454,744...127,507,941
Ensembl chr 3:127,454,811...127,507,817

Etl4

enhancer trap locus 4

decreases expression

nickel sulfate results in decreased expression of KIAA1217 mRNA

NCBI chr17:82,841,075...83,304,868
Ensembl chr17:82,495,041...83,304,715

Ets1

ETS proto-oncogene 1, transcription factor

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

Ets2

ETS proto-oncogene 2, transcription factor

increases expression

nickel sulfate results in increased expression of ETS2 mRNA

NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319

Etv2

ETS variant transcription factor 2

increases expression

nickel sulfate results in increased expression of ETV2 mRNA

NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431

Etv6

ETS variant transcription factor 6

increases expression

nickel sulfate results in increased expression of ETV6 mRNA

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

Eva1c

eva-1 homolog C

increases expression

nickel sulfate results in increased expression of EVA1C mRNA

NCBI chr11:30,089,510...30,163,596
Ensembl chr11:30,089,365...30,163,596

Evi2b

ecotropic viral integration site 2B

increases expression

nickel sulfate results in increased expression of EVI2B mRNA

NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560

Exoc2

exocyst complex component 2

increases expression

nickel sulfate results in increased expression of EXOC2 mRNA

NCBI chr17:33,506,289...33,698,246
Ensembl chr17:33,506,338...33,693,289

Exoc6

exocyst complex component 6

decreases expression

nickel sulfate results in decreased expression of EXOC6 mRNA

NCBI chr 1:235,314,612...235,457,824
Ensembl chr 1:235,300,369...235,457,015

Exosc8

exosome component 8

decreases expression

nickel sulfate results in decreased expression of EXOSC8 mRNA

NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928

Exph5

exophilin 5

decreases expression

nickel sulfate results in decreased expression of EXPH5 mRNA

NCBI chr 8:53,698,825...53,775,371
Ensembl chr 8:53,698,852...53,773,169

Eya1

EYA transcriptional coactivator and phosphatase 1

decreases expression

nickel sulfate results in decreased expression of EYA1 mRNA

NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483

Eya2

EYA transcriptional coactivator and phosphatase 2

decreases expression

nickel sulfate results in decreased expression of EYA2 mRNA

NCBI chr 3:154,335,598...154,519,006
Ensembl chr 3:154,335,400...154,518,793

F13a1

coagulation factor XIII A1 chain

decreases expression

nickel sulfate results in decreased expression of F13A1 mRNA

NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700

F2rl2

coagulation factor II (thrombin) receptor-like 2

decreases expression

nickel sulfate results in decreased expression of F2RL2 mRNA

NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098

coagulation factor III, tissue factor

increases expression
decreases expression

nickel sulfate results in increased expression of F3 mRNA
nickel sulfate results in decreased expression of F3 mRNA

PMID:16100012 PMID:22714537

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

Fabp3

fatty acid binding protein 3

increases expression
decreases expression

nickel sulfate results in increased expression of FABP3 mRNA
nickel sulfate results in decreased expression of FABP3 mRNA

PMID:17382205 PMID:22714537

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

Fabp5

fatty acid binding protein 5

increases expression
decreases expression

nickel sulfate results in increased expression of FABP5 mRNA
nickel sulfate results in decreased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

Fahd2a

fumarylacetoacetate hydrolase domain containing 2A

increases expression

nickel sulfate results in increased expression of FAHD2A mRNA

NCBI chr 3:114,657,176...114,665,349
Ensembl chr 3:114,655,865...114,665,356

Fam117b

family with sequence similarity 117, member B

increases expression

nickel sulfate results in increased expression of FAM117B mRNA

NCBI chr 9:61,340,284...61,418,531
Ensembl chr 9:61,340,249...61,408,483

Fam120c

family with sequence similarity 120 member C

increases expression

nickel sulfate results in increased expression of FAM120C mRNA

NCBI chr X:20,324,046...20,477,831
Ensembl chr X:20,323,381...20,477,275

Fam162a

family with sequence similarity 162, member A

increases expression
decreases expression

nickel sulfate results in increased expression of FAM162A mRNA
nickel sulfate results in decreased expression of FAM162A mRNA

PMID:17382205 PMID:22714537

NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239

Fam171b

family with sequence similarity 171, member B

increases expression

nickel sulfate results in increased expression of FAM171B mRNA

NCBI chr 3:68,930,755...68,986,113
Ensembl chr 3:68,930,822...68,986,127

Fam221a

family with sequence similarity 221, member A

decreases expression

nickel sulfate results in decreased expression of FAM221A mRNA

NCBI chr 4:78,337,296...78,358,918
Ensembl chr 4:78,337,296...78,358,909

Fam3c

FAM3 metabolism regulating signaling molecule C

decreases expression

nickel sulfate results in decreased expression of FAM3C mRNA

NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078

Fam43a

family with sequence similarity 43, member A

increases expression

nickel sulfate results in increased expression of FAM43A mRNA

NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401

Fam81a

family with sequence similarity 81, member A

increases expression

nickel sulfate results in increased expression of FAM81A mRNA

NCBI chr 8:70,762,852...70,821,898
Ensembl chr 8:70,763,614...70,821,875

Fanca

FA complementation group A

increases expression

nickel sulfate results in increased expression of FANCA mRNA

NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527

Farp1

FERM, ARH/RhoGEF and pleckstrin domain protein 1

increases expression

nickel sulfate results in increased expression of FARP1 mRNA

NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299

Fars2

phenylalanyl-tRNA synthetase 2, mitochondrial

increases expression

nickel sulfate results in increased expression of FARS2 mRNA

NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337

Fasn

fatty acid synthase

increases expression
decreases expression

nickel sulfate results in increased expression of FASN mRNA
nickel sulfate results in decreased expression of FASN mRNA

PMID:16100012 PMID:16780908

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

Faxc

failed axon connections homolog, metaxin like GST domain containing

increases expression

nickel sulfate results in increased expression of FAXC mRNA

NCBI chr 5:35,480,137...35,539,741
Ensembl chr 5:35,480,402...35,544,446

Fbln2

fibulin 2

decreases expression

nickel sulfate results in decreased expression of FBLN2 mRNA

NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948

Fbn1

fibrillin 1

decreases expression

nickel sulfate results in decreased expression of FBN1 mRNA

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

Fbn2

fibrillin 2

decreases expression

nickel sulfate results in decreased expression of FBN2 mRNA

NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976

Fbxo32

F-box protein 32

increases expression

nickel sulfate results in increased expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

Fbxo4

F-box protein 4

decreases expression

nickel sulfate results in decreased expression of FBXO4 mRNA

NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792

Fbxo9

f-box protein 9

decreases expression

nickel sulfate results in decreased expression of FBXO9 mRNA

NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949

Fbxw7

F-box and WD repeat domain containing 7

multiple interactions

FBXW7 mRNA affects the reaction [nickel sulfate results in increased degradation of MYC protein]; FBXW7 protein affects the reaction [nickel sulfate results in increased degradation of MYC protein]

PMID:20046830

NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941

Fcgr2b

Fc gamma receptor 2B

increases expression

nickel sulfate results in increased expression of FCGR2B mRNA

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

Fech

ferrochelatase

increases expression

nickel sulfate results in increased expression of FECH mRNA

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

Fetub

fetuin B

decreases expression

nickel sulfate results in decreased expression of FETUB mRNA

NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135

Fez2

fasciculation and elongation protein zeta 2

increases expression

nickel sulfate results in increased expression of FEZ2 mRNA

NCBI chr 6:16,654,572...16,694,628
Ensembl chr 6:16,654,614...16,694,626

Fgf1

fibroblast growth factor 1

decreases expression

nickel sulfate results in decreased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

Fgf2

fibroblast growth factor 2

increases expression

nickel sulfate results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

Fgf5

fibroblast growth factor 5

decreases expression

nickel sulfate results in decreased expression of FGF5 mRNA

NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997

Fgfr2

fibroblast growth factor receptor 2

increases expression

nickel sulfate results in increased expression of FGFR2 protein

PMID:12930308

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

Fgl2

fibrinogen-like 2

decreases expression

nickel sulfate results in decreased expression of FGL2 mRNA

NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207

Filip1l

filamin A interacting protein 1-like

decreases expression

nickel sulfate results in decreased expression of FILIP1L mRNA

NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415

Fkbp1a

FKBP prolyl isomerase 1A

decreases expression

nickel sulfate results in decreased expression of FKBP1A mRNA

NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743

Fkbp1b

FKBP prolyl isomerase 1B

decreases expression

nickel sulfate results in decreased expression of FKBP1B mRNA

NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653

Flg

filaggrin

decreases expression

nickel sulfate results in decreased expression of FLG mRNA

NCBI chr 2:178,884,793...178,912,986

Fli1

Fli-1 proto-oncogene, ETS transcription factor

increases expression

nickel sulfate results in increased expression of FLI1 mRNA

NCBI chr 8:30,831,422...30,950,468
Ensembl chr 8:30,832,753...30,950,433

Flna

filamin A

increases expression

nickel sulfate results in increased expression of FLNA mRNA

NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052

Flnc

filamin C

decreases expression

nickel sulfate results in decreased expression of FLNC mRNA

NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844

Flot1

flotillin 1

increases expression

nickel sulfate results in increased expression of FLOT1 mRNA

NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978

Flt1

Fms related receptor tyrosine kinase 1

increases expression

nickel sulfate results in increased expression of FLT1 mRNA

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

Flt3lg

Fms related receptor tyrosine kinase 3 ligand

decreases expression

nickel sulfate results in decreased expression of FLT3L mRNA

NCBI chr 1:95,615,056...95,620,463
Ensembl chr 1:95,609,370...95,620,463

Fmr1

fragile X messenger ribonucleoprotein 1

decreases expression

nickel sulfate results in decreased expression of FMR1 mRNA

NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050

Fn1

fibronectin 1

increases expression

nickel sulfate results in increased expression of FN1 mRNA; nickel sulfate results in increased expression of FN1 protein

PMID:22648416

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

Fndc3a

fibronectin type III domain containing 3a

increases expression

nickel sulfate results in increased expression of FNDC3A mRNA

PMID:11114790

NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

nickel sulfate results in increased expression of FOS mRNA

PMID:16780908 PMID:19131640

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Fosl2

FOS like 2, AP-1 transcription factor subunit

decreases expression
increases expression

nickel sulfate results in decreased expression of FOSL2 mRNA
nickel sulfate results in increased expression of FOSL2 mRNA

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

Foxc2

forkhead box C2

increases expression

nickel sulfate results in increased expression of FOXC2 mRNA

NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737

Foxf2

forkhead box F2

increases expression

nickel sulfate results in increased expression of FOXF2 mRNA

NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176

Frmd3

FERM domain containing 3

increases expression

nickel sulfate results in increased expression of FRMD3 mRNA

NCBI chr 5:87,764,755...88,031,091
Ensembl chr 5:87,764,604...88,031,091

Frmd4a

FERM domain containing 4A

decreases expression

nickel sulfate results in decreased expression of FRMD4A mRNA

NCBI chr17:73,667,787...74,258,487
Ensembl chr17:73,667,789...74,258,687

Frmd5

FERM domain containing 5

decreases expression

nickel sulfate results in decreased expression of FRMD5 mRNA

NCBI chr 3:108,492,099...108,763,715
Ensembl chr 3:108,474,562...108,763,498

Fry

FRY microtubule binding protein

decreases expression

nickel sulfate results in decreased expression of FRY mRNA

NCBI chr12:4,493,890...4,887,118
Ensembl chr12:4,493,891...4,799,116

Fst

follistatin

increases expression

nickel sulfate results in increased expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

Fstl3

follistatin like 3

decreases expression

nickel sulfate results in decreased expression of FSTL3 mRNA

NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639

Fth1

ferritin heavy chain 1

increases expression

nickel sulfate results in increased expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

Ftl1

ferritin light chain 1

increases expression

nickel sulfate results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

Ftmt

ferritin mitochondrial

increases expression

nickel sulfate results in increased expression of FTMT protein

PMID:19679144

NCBI chr18:45,758,874...45,760,123
Ensembl chr18:45,758,874...45,760,123

Fuca1

alpha-L-fucosidase 1

decreases expression

nickel sulfate results in decreased expression of FUCA1 mRNA

NCBI chr 5:148,152,718...148,169,972
Ensembl chr 5:148,152,700...148,169,972

Fundc2

FUN14 domain containing 2

decreases expression

nickel sulfate results in decreased expression of FUNDC2 mRNA

NCBI chr18:128,473...138,232
Ensembl chr18:132,248...138,345

Fus

Fus RNA binding protein

increases expression

nickel sulfate results in increased expression of FUS mRNA

NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414

Fyn

FYN proto-oncogene, Src family tyrosine kinase

increases expression

nickel sulfate results in increased expression of FYN mRNA

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

Fzd2

frizzled class receptor 2

decreases expression

nickel sulfate results in decreased expression of FZD2 mRNA

PMID:16100012 PMID:16166746

NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334

Fzd3

frizzled class receptor 3

decreases expression

nickel sulfate results in decreased expression of FZD3 mRNA

NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369

Fzd6

frizzled class receptor 6

increases expression

nickel sulfate results in increased expression of FZD6 mRNA

NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776

G4 protein

increases expression

nickel sulfate results in increased expression of C6ORF47 mRNA

NCBI chr20:3,693,691...3,696,194
Ensembl chr20:3,693,649...3,696,088

G6pd

glucose-6-phosphate dehydrogenase

increases expression
multiple interactions
decreases activity

nickel sulfate results in increased expression of G6PD mRNA
naringin inhibits the reaction [nickel sulfate results in decreased activity of G6PD protein]

PMID:20566472 PMID:20950607

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

Gabarapl1

GABA type A receptor associated protein like 1

increases expression

nickel sulfate results in increased expression of GABARAPL1 mRNA

NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450

Gad1

glutamate decarboxylase 1

increases expression

nickel sulfate results in increased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

Gal

galanin and GMAP prepropeptide

decreases expression

nickel sulfate results in decreased expression of GAL mRNA

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

Gal3st4

galactose-3-O-sulfotransferase 4

increases expression

nickel sulfate results in increased expression of GAL3ST4 mRNA

NCBI chr12:17,267,963...17,276,951
Ensembl chr12:17,267,963...17,276,833

Galc

galactosylceramidase

decreases expression

nickel sulfate results in decreased expression of GALC mRNA

NCBI chr 6:117,452,888...117,522,281
Ensembl chr 6:117,452,895...117,515,830

Galns

galactosamine (N-acetyl)-6-sulfatase

increases expression

nickel sulfate results in increased expression of GALNS mRNA

NCBI chr19:50,628,639...50,662,477
Ensembl chr19:50,628,552...50,662,246

Gan

gigaxonin

increases expression

nickel sulfate results in increased expression of GAN mRNA

NCBI chr19:45,207,783...45,265,066
Ensembl chr19:45,207,184...45,254,107

Gapdh

glyceraldehyde-3-phosphate dehydrogenase

affects expression

nickel sulfate affects the expression of GAPDH mRNA

PMID:12718980

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

Gas6

growth arrest specific 6

decreases expression

nickel sulfate results in decreased expression of GAS6 mRNA

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

Gas8

growth arrest specific 8

increases expression

nickel sulfate results in increased expression of GAS8 mRNA

NCBI chr19:51,552,770...51,572,323
Ensembl chr19:51,552,816...51,572,305

Gatm

glycine amidinotransferase

decreases expression

nickel sulfate results in decreased expression of GATM mRNA

NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129

Gbp1

guanylate binding protein 1

increases expression

nickel sulfate results in increased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

Gbp4

guanylate binding protein 4

increases expression

nickel sulfate results in increased expression of GBP4 mRNA

NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879

Gclc

glutamate-cysteine ligase, catalytic subunit

increases expression

nickel sulfate results in increased expression of GCLC mRNA

PMID:16100012 PMID:20491607 PMID:20566472

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

Gclm

glutamate cysteine ligase, modifier subunit

increases expression

nickel sulfate results in increased expression of GCLM mRNA

PMID:16314067 PMID:20566472

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

Gcnt2

glucosaminyl (N-acetyl) transferase 2

increases expression

nickel sulfate results in increased expression of GCNT2 mRNA

NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611

Gcnt4

glucosaminyl (N-acetyl) transferase 4

increases expression

nickel sulfate results in increased expression of GCNT4 mRNA

NCBI chr 2:28,253,325...28,283,082
Ensembl chr 2:28,252,860...28,283,082

Gcsh

glycine cleavage system protein H

increases expression

nickel sulfate results in increased expression of GCSH mRNA

NCBI chr19:45,036,013...45,046,770
Ensembl chr19:45,036,011...45,046,792

Gdf15

growth differentiation factor 15

increases expression

nickel sulfate results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

Gdnf

glial cell derived neurotrophic factor

decreases expression

nickel sulfate results in decreased expression of GDNF mRNA

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

Gfpt2

glutamine-fructose-6-phosphate transaminase 2

increases expression

nickel sulfate results in increased expression of GFPT2 mRNA

NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329

Gfra2

GDNF family receptor alpha 2

decreases expression

nickel sulfate results in decreased expression of GFRA2 mRNA

NCBI chr15:45,941,841...46,033,715
Ensembl chr15:45,941,828...46,033,714

Gfus

GDP-L-fucose synthase

increases expression

nickel sulfate results in increased expression of GFUS mRNA

NCBI chr 7:107,612,087...107,617,005
Ensembl chr 7:107,612,094...107,616,948

Ggt1

gamma-glutamyltransferase 1

increases activity
multiple interactions

nickel sulfate results in increased activity of GGT1 protein
troxerutin inhibits the reaction [nickel sulfate results in increased activity of GGT1 protein]

PMID:24112957

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

Gins1

GINS complex subunit 1

decreases expression

nickel sulfate results in decreased expression of GINS1 mRNA

NCBI chr 3:139,724,513...139,745,930
Ensembl chr 3:139,724,490...139,745,936

Gins2

GINS complex subunit 2

increases expression

nickel sulfate results in increased expression of GINS2 mRNA

NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339

Gja1

gap junction protein, alpha 1

increases expression

nickel sulfate results in increased expression of GJA1 mRNA

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

Glcci1

glucocorticoid induced 1

decreases expression

nickel sulfate results in decreased expression of GLCCI1 mRNA

NCBI chr 4:36,307,956...36,635,614
Ensembl chr 4:36,307,903...36,635,612

Glipr1

GLI pathogenesis-related 1

decreases expression

nickel sulfate results in decreased expression of GLIPR1 mRNA

NCBI chr 7:47,487,342...47,498,974
Ensembl chr 7:47,487,345...47,498,429

Glipr2

GLI pathogenesis-related 2

decreases expression

nickel sulfate results in decreased expression of GLIPR2 mRNA

NCBI chr 5:58,170,417...58,202,258
Ensembl chr 5:58,170,425...58,202,272

Glis3

GLIS family zinc finger 3

decreases expression

nickel sulfate results in decreased expression of GLIS3 mRNA

NCBI chr 1:225,976,029...226,395,849
Ensembl chr 1:225,976,326...226,395,899

Glp2r

glucagon-like peptide 2 receptor

increases expression

nickel sulfate results in increased expression of GLP2R mRNA

NCBI chr10:52,402,748...52,466,012
Ensembl chr10:52,402,748...52,466,012

Glrb

glycine receptor, beta

decreases expression

nickel sulfate results in decreased expression of GLRB mRNA

NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489

Glul

glutamate-ammonia ligase

increases expression

nickel sulfate results in increased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

Gm2a

ganglioside GM2 activator

decreases expression
increases expression

nickel sulfate results in decreased expression of GM2A mRNA
nickel sulfate results in increased expression of GM2A mRNA

NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757

Gmpr

guanosine monophosphate reductase

increases expression

nickel sulfate results in increased expression of GMPR mRNA

NCBI chr17:19,151,820...19,189,626
Ensembl chr17:19,151,815...19,189,621

Gna15

G protein subunit alpha 15

increases expression

nickel sulfate results in increased expression of GNA15 mRNA

NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508

Gnal

G protein subunit alpha L

increases expression

nickel sulfate results in increased expression of GNAL mRNA

NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599

Gnaz

G protein subunit alpha z

increases expression

nickel sulfate results in increased expression of GNAZ mRNA

NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907

Gnb2

G protein subunit beta 2

increases expression

nickel sulfate results in increased expression of GNB2 mRNA

NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019

Gng11

G protein subunit gamma 11

increases expression

nickel sulfate results in increased expression of GNG11 mRNA

NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442

Gp9

glycoprotein IX (platelet)

increases expression

nickel sulfate results in increased expression of GP9 mRNA

NCBI chr 4:120,235,500...120,237,110
Ensembl chr 4:120,235,421...120,237,110

Gpat3

glycerol-3-phosphate acyltransferase 3

increases expression

nickel sulfate results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

Gpatch2l

G patch domain containing 2-like

decreases expression

nickel sulfate results in decreased expression of GPATCH2L mRNA

NCBI chr 6:105,883,383...105,935,644
Ensembl chr 6:105,883,460...105,934,888

Gpc4

glypican 4

increases expression

nickel sulfate results in increased expression of GPC4 mRNA

NCBI chr X:131,644,711...131,755,349
Ensembl chr X:131,644,704...131,755,284

Gper1

G protein-coupled estrogen receptor 1

increases expression

nickel sulfate results in increased expression of GPER1 mRNA

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

Gphn

gephyrin

decreases expression

nickel sulfate results in decreased expression of GPHN mRNA

NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612

Gpm6b

glycoprotein m6b

increases expression

nickel sulfate results in increased expression of GPM6B mRNA

NCBI chr X:28,057,788...28,204,409
Ensembl chr X:28,059,450...28,204,211

Gpnmb

glycoprotein nmb

increases expression

nickel sulfate results in increased expression of GPNMB mRNA

PMID:16314067 PMID:22714537

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

Gpr39

G protein-coupled receptor 39

increases expression

nickel sulfate results in increased expression of GPR39 mRNA

NCBI chr13:37,115,258...37,327,312
Ensembl chr13:37,115,102...37,328,267

Gpr4

G protein-coupled receptor 4

decreases expression

nickel sulfate results in decreased expression of GPR4 mRNA

NCBI chr 1:78,865,376...78,877,126
Ensembl chr 1:78,865,409...78,876,599

Gprc5b

G protein-coupled receptor, class C, group 5, member B

increases expression

nickel sulfate results in increased expression of GPRC5B mRNA

NCBI chr 1:173,316,904...173,340,933
Ensembl chr 1:173,316,907...173,340,932

Gpt

glutamic--pyruvic transaminase

increases activity
multiple interactions

nickel sulfate results in increased activity of GPT protein
puerarin inhibits the reaction [nickel sulfate results in increased activity of GPT protein]
troxerutin inhibits the reaction [nickel sulfate results in increased activity of GPT protein]

PMID:24112957 PMID:26607348

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

Gpx3

glutathione peroxidase 3

increases expression

nickel sulfate results in increased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

Gpx4

glutathione peroxidase 4

increases expression
multiple interactions

nickel sulfate results in increased expression of GPX4 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of GPX4 mRNA

PMID:18651567 PMID:31734292

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

Gpx7

glutathione peroxidase 7

decreases expression

nickel sulfate results in decreased expression of GPX7 mRNA

NCBI chr 5:123,145,151...123,153,141
Ensembl chr 5:123,144,331...123,153,004

Gramd1c

GRAM domain containing 1C

increases expression

nickel sulfate results in increased expression of GRAMD1C mRNA

NCBI chr11:56,633,229...56,718,570
Ensembl chr11:56,633,227...56,718,570

Grem1

gremlin 1, DAN family BMP antagonist

decreases expression

nickel sulfate results in decreased expression of GREM1 mRNA

NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082

Gse1

Gse1 coiled-coil protein

increases expression

nickel sulfate results in increased expression of GSE1 mRNA

NCBI chr19:48,274,164...48,629,456
Ensembl chr19:48,274,127...48,629,458

Gsk3b

glycogen synthase kinase 3 beta

increases expression

nickel sulfate results in increased expression of GSK3B mRNA

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

Gsn

gelsolin

increases expression

nickel sulfate results in increased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

Gspt2

G1 to S phase transition 2

decreases expression

nickel sulfate results in decreased expression of GSPT2 mRNA

NCBI chr X:59,587,237...59,589,758
Ensembl chr X:59,587,276...59,594,162

Gsr

glutathione-disulfide reductase

increases expression
decreases activity
multiple interactions

nickel sulfate results in increased expression of GSR mRNA
nickel sulfate results in decreased activity of GSR protein
naringin inhibits the reaction [nickel sulfate results in decreased activity of GSR protein]

PMID:20566472 PMID:20950607

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

Gtf2b

general transcription factor IIB

increases expression

nickel sulfate results in increased expression of GTF2B mRNA

NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651

Gtpbp6

GTP binding protein 6 (putative)

increases expression

nickel sulfate results in increased expression of GTPBP6 mRNA

NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873

Guk1

guanylate kinase 1

increases expression

nickel sulfate results in increased expression of GUK1 mRNA

NCBI chr10:43,971,514...43,988,658
Ensembl chr10:43,971,509...43,980,107

Gulp1

GULP PTB domain containing engulfment adaptor 1

increases expression

nickel sulfate results in increased expression of GULP1 mRNA

NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005

Gzf1

GDNF-inducible zinc finger protein 1

decreases expression

nickel sulfate results in decreased expression of GZF1 mRNA

NCBI chr 3:136,119,004...136,131,223
Ensembl chr 3:136,119,113...136,131,223

Gzmf

granzyme F

decreases expression

nickel sulfate results in decreased expression of GZMF mRNA

NCBI chr15:30,005,361...30,018,649
Ensembl chr15:30,007,267...30,018,649

H1f0

H1.0 linker histone

decreases expression

nickel sulfate results in decreased expression of H1-0 mRNA

NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694

H1f10

H1.10 linker histone

increases expression

nickel sulfate results in increased expression of H1-10 mRNA

NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448

H2ac18

H2A clustered histone 18

increases expression

nickel sulfate results in increased expression of H2AC18 mRNA

NCBI chr 2:183,808,398...183,808,992

H3f4

H3.4 histone, cluster member

increases methylation

nickel sulfate results in increased methylation of H3-4 protein
nickel sulfate results in increased methylation of H3F4 protein

PMID:19371620

NCBI chr10:43,740,702...43,741,262

H4cl1

histone H4C like 1

decreases expression

nickel sulfate results in decreased expression of H4C6 mRNA

NCBI chr17:41,368,743...41,426,735

Hacd4

3-hydroxyacyl-CoA dehydratase 4

decreases expression

nickel sulfate results in decreased expression of HACD4 mRNA

NCBI chr 5:102,887,597...102,915,376
Ensembl chr 5:102,887,588...102,915,338

Hba-a1

hemoglobin alpha, adult chain 1

affects expression

nickel sulfate affects the expression of HBA-A1 mRNA

PMID:12718980

NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392

Hbb-b2

hemoglobin, beta adult minor chain

decreases expression

nickel sulfate results in decreased expression of HBB-B2 mRNA

NCBI chr 1:158,243,696...158,245,076
Ensembl chr 1:158,120,200...158,252,012

Heatr5b

HEAT repeat containing 5B

decreases expression

nickel sulfate results in decreased expression of HEATR5B mRNA

NCBI chr 6:16,243,424...16,323,444
Ensembl chr 6:16,243,461...16,323,435

Herc4

HECT and RLD domain containing E3 ubiquitin protein ligase 4

decreases expression

nickel sulfate results in decreased expression of HERC4 mRNA

NCBI chr20:25,329,972...25,404,657
Ensembl chr20:25,330,280...25,404,657

Herc6

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

increases expression

nickel sulfate results in increased expression of HERC6 mRNA

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

Hes1

hes family bHLH transcription factor 1

increases expression

nickel sulfate results in increased expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

Hif1a

hypoxia inducible factor 1 subunit alpha

increases expression
increases stability
decreases hydroxylation
decreases expression
multiple interactions

nickel sulfate results in increased expression of HIF1A mRNA; nickel sulfate results in increased expression of HIF1A protein
nickel sulfate results in increased stability of HIF1A protein
nickel sulfate results in decreased hydroxylation of HIF1A protein
nickel sulfate results in decreased expression of HIF1A mRNA
[chromium hexavalent ion co-treated with nickel sulfate] results in increased expression of HIF1A protein; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in decreased expression of USP28 protein]; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in increased degradation of MYC protein]; [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in decreased expression of HIF1A mRNA; [nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of HIF1A protein; [potassium chromate(VI) co-treated with nickel sulfate] results in increased expression of HIF1A protein; [U 0126 co-treated with SB 203580] inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of HIF1A protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in decreased hydroxylation of HIF1A protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of HIF1A protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in increased stability of HIF1A protein]; Dinoprostone promotes the reaction [nickel sulfate results in increased expression of and results in increased activity of HIF1A protein]; HIF1A mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PTGS2 mRNA]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PTGS2 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL1 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL5 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL8 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of VEGFA protein]; HIF1A protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; macrophage stimulatory lipopeptide 2 co-treated with [nickel sulfate results in increased expression of HIF1A protein]; nickel sulfate affects the localization of and results in increased stability of HIF1A protein; nickel sulfate promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; nickel sulfate results in increased expression of and results in increased activity of HIF1A protein; SB 203580 inhibits the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of HIF1A protein]; U 0126 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of HIF1A protein]

PMID:16288478 PMID:16314067 PMID:17382205 PMID:18832182 PMID:19074761 More...

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Hilpda

hypoxia inducible lipid droplet-associated

increases expression

nickel sulfate results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

Hint3

histidine triad nucleotide binding protein 3

increases expression

nickel sulfate results in increased expression of HINT3 mRNA

NCBI chr 1:27,035,936...27,045,799
Ensembl chr 1:27,035,905...27,047,721

Hip1

huntingtin interacting protein 1

increases expression

nickel sulfate results in increased expression of HIP1 mRNA

NCBI chr12:21,133,364...21,267,796
Ensembl chr12:21,133,406...21,267,725

Hipk2

homeodomain interacting protein kinase 2

increases expression

nickel sulfate results in increased expression of HIPK2 mRNA

NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223

Hivep1

HIVEP zinc finger 1

increases expression

nickel sulfate results in increased expression of HIVEP1 mRNA

NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956

Hk2

hexokinase 2

decreases expression

nickel sulfate results in decreased expression of HK2 mRNA

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

Hmgcs1

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

nickel sulfate results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

Hmox1

heme oxygenase 1

increases expression
multiple interactions
decreases expression

nickel sulfate results in increased expression of HMOX1 mRNA
Quercetin inhibits the reaction [nickel sulfate results in decreased expression of HMOX1 protein]

PMID:16314067 PMID:19033392 PMID:20146380 PMID:20491607 PMID:20566472 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hnrnpa1

heterogeneous nuclear ribonucleoprotein A1

increases expression

nickel sulfate results in increased expression of HNRNPA1 mRNA

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

Homer1

homer scaffold protein 1

increases expression

nickel sulfate results in increased expression of HOMER1 mRNA

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

Hoxa1

homeobox A1

increases expression

nickel sulfate results in increased expression of HOXA1 mRNA

NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504

Hoxa2

homeobox A2

increases expression

nickel sulfate results in increased expression of HOXA2 mRNA

NCBI chr 4:81,262,668...81,266,970
Ensembl chr 4:81,262,768...81,265,044

Hoxa3

homeobox A3

increases expression

nickel sulfate results in increased expression of HOXA3 mRNA

NCBI chr 4:81,269,243...81,313,218
Ensembl chr 4:81,269,243...81,313,218

Hoxc10

homeo box C10

increases expression

nickel sulfate results in increased expression of HOXC10 mRNA

NCBI chr 7:134,103,741...134,108,966
Ensembl chr 7:134,103,643...134,108,966

Hoxc13

homeobox C13

increases expression

nickel sulfate results in increased expression of HOXC13 mRNA

NCBI chr 7:134,058,640...134,065,479
Ensembl chr 7:134,058,640...134,064,800

Hoxc9

homeobox C9

increases expression

nickel sulfate results in increased expression of HOXC9 mRNA

NCBI chr 7:134,118,817...134,121,497
Ensembl chr 7:134,118,817...134,121,492

Hpcal1

hippocalcin-like 1

increases expression

nickel sulfate results in increased expression of HPCAL1 mRNA

NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687

Hpgd

15-hydroxyprostaglandin dehydrogenase

decreases expression

nickel sulfate results in decreased expression of HPGD mRNA

NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228

Hprt1

hypoxanthine phosphoribosyltransferase 1

affects expression

nickel sulfate affects the expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

Hps5

HPS5, biogenesis of lysosomal organelles complex 2 subunit 2

increases expression

nickel sulfate results in increased expression of HPS5 mRNA

NCBI chr 1:97,281,626...97,320,945
Ensembl chr 1:97,247,598...97,321,019

Hs6st1

heparan sulfate 6-O-sulfotransferase 1

increases expression

nickel sulfate results in increased expression of HS6ST1 mRNA

NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683

Hsd17b3

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions
decreases expression

[CGA protein co-treated with nickel sulfate] results in decreased expression of HSD17B3 mRNA; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]

PMID:29567110

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

Hsd17b6

hydroxysteroid (17-beta) dehydrogenase 6

increases expression

nickel sulfate results in increased expression of HSD17B6 mRNA

NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425

Hsd17b7

hydroxysteroid (17-beta) dehydrogenase 7

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of HSD17B7 mRNA

NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017

Hsdl1

hydroxysteroid dehydrogenase like 1

increases expression

nickel sulfate results in increased expression of HSDL1 mRNA

NCBI chr19:47,615,794...47,631,892
Ensembl chr19:47,615,796...47,631,846

Hsf1

heat shock transcription factor 1

increases expression

nickel sulfate results in increased expression of HSF1 mRNA

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

Hspa12a

heat shock protein family A (Hsp70) member 12A

increases expression

nickel sulfate results in increased expression of HSPA12A mRNA

NCBI chr 1:257,935,642...258,096,602
Ensembl chr 1:257,935,644...258,096,846

Hspa1a

heat shock protein family A (Hsp70) member 1A

increases expression

nickel sulfate results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

Hspa5

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]
nickel sulfate results in increased expression of HSPA5 mRNA; nickel sulfate results in increased expression of HSPA5 protein

PMID:28296042

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

Hspa6l-ps1

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

nickel sulfate results in increased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

Hspb8

heat shock protein family B (small) member 8

increases expression

nickel sulfate results in increased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

Hspg2

heparan sulfate proteoglycan 2

decreases expression

nickel sulfate results in decreased expression of HSPG2 mRNA

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

Htatip2

HIV-1 Tat interactive protein 2

increases expression

nickel sulfate results in increased expression of HTATIP2 mRNA

NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629

Htr1d

5-hydroxytryptamine receptor 1D

increases expression

nickel sulfate results in increased expression of HTR1D mRNA

NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619

Htr7

5-hydroxytryptamine receptor 7

decreases expression

nickel sulfate results in decreased expression of HTR7 mRNA

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

Icam1

intercellular adhesion molecule 1

increases expression
affects expression

nickel sulfate results in increased expression of ICAM1 mRNA
nickel sulfate results in increased expression of ICAM1 protein
nickel sulfate affects the expression of ICAM1 mRNA

PMID:11114790 PMID:18202158 PMID:19702435 PMID:20417223 PMID:29540657

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Id1

inhibitor of DNA binding 1

increases expression

nickel sulfate results in increased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

Id2

inhibitor of DNA binding 2

increases expression

nickel sulfate results in increased expression of ID2 mRNA

PMID:16780908 PMID:20146380

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

Id3

inhibitor of DNA binding 3

increases expression

nickel sulfate results in increased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

Id4

inhibitor of DNA binding 4

increases expression

nickel sulfate results in increased expression of ID4 mRNA

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

Idh3b

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta

decreases expression

nickel sulfate results in decreased expression of IDH3B mRNA

NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982

Ido1

indoleamine 2,3-dioxygenase 1

increases expression

nickel sulfate results in increased expression of IDO1 mRNA

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

Ids

iduronate 2-sulfatase

decreases expression

nickel sulfate results in decreased expression of IDS mRNA

NCBI chr X:149,025,976...149,046,641
Ensembl chr X:149,025,976...149,046,663

Ier2

immediate early response 2

increases expression

nickel sulfate results in increased expression of IER2 mRNA

NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211

Ier3

immediate early response 3

increases expression

nickel sulfate results in increased expression of IER3 mRNA

PMID:17374397 PMID:18651567 PMID:22714537

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

Ifi30

IFI30, lysosomal thiol reductase

increases expression

nickel sulfate results in increased expression of IFI30 mRNA

NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175

Ifi44

interferon-induced protein 44

increases expression

nickel sulfate results in increased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

Ifih1

interferon induced with helicase C domain 1

increases expression

nickel sulfate results in increased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

Ifit2

interferon-induced protein with tetratricopeptide repeats 2

decreases expression

nickel sulfate results in decreased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

Ifitm1

interferon induced transmembrane protein 1

increases expression

nickel sulfate results in increased expression of IFITM1 mRNA

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

Ifnb1

interferon beta 1

increases expression

nickel sulfate results in increased expression of IFNB1 mRNA

PMID:20525893

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

Ifne

interferon, epsilon

decreases expression

nickel sulfate results in decreased expression of IFNE mRNA

NCBI chr 5:103,571,630...103,572,290
Ensembl chr 5:103,569,675...103,572,256

Ifng

interferon gamma

multiple interactions
increases secretion
affects expression
increases expression

[nickel sulfate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Cholecalciferol inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Cyclosporine inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Hydrocortisone inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; IFNG protein promotes the reaction [nickel sulfate results in increased expression of IL27 mRNA]; Zinc Sulfate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]
nickel sulfate affects the expression of IFNG mRNA
nickel sulfate results in increased expression of IFNG mRNA

PMID:10929769 PMID:11145678 PMID:14650623 PMID:15270870 PMID:15663561 More...

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

Ifrd1

interferon-related developmental regulator 1

increases expression

nickel sulfate results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

Ift56

intraflagellar transport 56

increases expression

nickel sulfate results in increased expression of IFT56 mRNA

NCBI chr 4:67,090,622...67,154,707
Ensembl chr 4:67,090,660...67,147,903

Ift70a2

intraflagellar transport 70A2

increases expression

nickel sulfate results in increased expression of IFT70A mRNA

NCBI chr 3:60,899,193...60,901,634
Ensembl chr 3:60,899,196...60,901,634

Ift88

intraflagellar transport 88

decreases expression

nickel sulfate results in decreased expression of IFT88 mRNA

NCBI chr15:31,573,325...31,666,068
Ensembl chr15:31,573,376...31,672,147

Igf2bp1

insulin-like growth factor 2 mRNA binding protein 1

decreases expression

nickel sulfate results in decreased expression of IGF2BP1 mRNA

NCBI chr10:80,908,300...80,951,097
Ensembl chr10:80,908,076...80,951,129

Igfbp4

insulin-like growth factor binding protein 4

decreases expression

nickel sulfate results in decreased expression of IGFBP4 mRNA

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

Igfbp6

insulin-like growth factor binding protein 6

decreases expression
increases expression

nickel sulfate results in decreased expression of IGFBP6 mRNA
nickel sulfate results in increased expression of IGFBP6 mRNA

PMID:16100012 PMID:16780908 PMID:17374397

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

Il10

interleukin 10

increases secretion
increases expression

nickel sulfate results in increased secretion of IL10 protein
nickel sulfate results in increased expression of IL10 mRNA

PMID:11145678 PMID:15347381

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

Il11

interleukin 11

decreases expression

nickel sulfate results in decreased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

Il12a

interleukin 12A

increases expression

nickel sulfate results in increased expression of IL12A mRNA

PMID:30421605

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

Il12b

interleukin 12B

affects expression
increases expression
increases secretion
multiple interactions

nickel sulfate affects the expression of IL12B mRNA
nickel sulfate results in increased expression of IL12B mRNA; nickel sulfate results in increased expression of IL12B protein
nickel sulfate results in increased secretion of IL12B protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [nickel sulfate results in increased secretion of IL12B protein]; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]

PMID:17636246 PMID:18202158 PMID:19101624 PMID:20525893 PMID:25673294 More...

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

Il13ra1

interleukin 13 receptor subunit alpha 1

increases expression

nickel sulfate results in increased expression of IL13RA1 mRNA

NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681

Il15

interleukin 15

affects expression

nickel sulfate affects the expression of IL15 mRNA

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

Il18

interleukin 18

decreases expression
increases expression

nickel sulfate results in decreased expression of IL18 mRNA
nickel sulfate results in increased expression of IL18 protein

PMID:18651567 PMID:23063874

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

Il1a

interleukin 1 alpha

increases secretion
multiple interactions

nickel sulfate results in increased secretion of IL1A protein
IL1A protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]; IL1A protein affects the reaction [nickel sulfate results in increased secretion of CXCL8 protein]

PMID:15679580

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

Il1b

interleukin 1 beta

increases expression
decreases expression
multiple interactions
increases secretion

nickel sulfate results in increased expression of IL1B mRNA
nickel sulfate results in decreased expression of IL1B mRNA
Quercetin inhibits the reaction [nickel sulfate results in increased expression of IL1B protein]
nickel sulfate results in increased expression of IL1B mRNA; nickel sulfate results in increased expression of IL1B protein
[Tetradecanoylphorbol Acetate co-treated with nickel sulfate] results in increased expression of and results in increased secretion of IL1B protein; Zinc Sulfate inhibits the reaction [nickel sulfate results in increased secretion of IL1B protein]

PMID:11033066 PMID:11114790 PMID:11751209 PMID:14650623 PMID:16166746 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il1r1

interleukin 1 receptor type 1

increases expression

nickel sulfate results in increased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

Il1r2

interleukin 1 receptor type 2

increases expression

nickel sulfate results in increased expression of IL1R2 mRNA

PMID:16166746 PMID:16780908

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

Il1rn

interleukin 1 receptor antagonist

increases expression

nickel sulfate results in increased expression of IL1RN mRNA

PMID:16166746 PMID:16780908

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

Il2

interleukin 2

increases secretion
multiple interactions
increases expression

nickel sulfate results in increased secretion of IL2 protein
[nickel sulfate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
nickel sulfate results in increased expression of IL2 protein

PMID:12925207 PMID:22381623 PMID:29594315

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

Il23a

interleukin 23 subunit alpha

increases expression

nickel sulfate results in increased expression of IL23A mRNA

PMID:30421605

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

Il24

interleukin 24

decreases expression

nickel sulfate results in decreased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

Il27

interleukin 27

increases expression
multiple interactions

nickel sulfate results in increased expression of IL27 mRNA
BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of IL27 mRNA]; IFNG protein promotes the reaction [nickel sulfate results in increased expression of IL27 mRNA]; Janus Kinase Inhibitors inhibits the reaction [nickel sulfate results in increased secretion of IL27 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of IL27 mRNA]; TLR4 protein affects the reaction [nickel sulfate results in increased expression of IL27 mRNA]

PMID:30421605

NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582

Il4

interleukin 4

increases secretion
increases expression

nickel sulfate results in increased secretion of IL4 protein
nickel sulfate results in increased expression of IL4 mRNA

PMID:10929769 PMID:11145678

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

Il4r

interleukin 4 receptor

increases expression

nickel sulfate results in increased expression of IL4RA mRNA; nickel sulfate results in increased expression of IL4RA protein

PMID:16100012 PMID:22381623

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

Il5

interleukin 5

multiple interactions
increases secretion

Cyclosporine inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]; Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]; Hydrocortisone inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]

PMID:10929769 PMID:15270870 PMID:15347381 PMID:15663561 PMID:19572476

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

Il6

interleukin 6

increases expression
multiple interactions
increases secretion