4'-hydroxydiclofenac - Ontology Report

4'-hydroxydiclofenac binds to and affects the activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

Ccl2

C-C motif chemokine ligand 2

increases expression

4'-hydroxydiclofenac results in increased expression of CCL2 mRNA

PMID:24104198

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Cyp2d4

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

[[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac

PMID:24246759

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

Esr1

estrogen receptor 1

affects activity

4'-hydroxydiclofenac affects the activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

Gstp1

glutathione S-transferase pi 1

increases glutathionylation
multiple interactions

GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]

PMID:24246759 PMID:24552538

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

Il10

interleukin 10

multiple interactions

4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

Il2

interleukin 2

multiple interactions

4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

Il4

interleukin 4

multiple interactions

4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

Il6

interleukin 6

multiple interactions

4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Mpo

myeloperoxidase

multiple interactions

4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased activity of MPO protein]; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to 4'-hydroxydiclofenac

PMID:28754375

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

Nqo1

NAD(P)H quinone dehydrogenase 1

multiple interactions

NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of 4'-hydroxydiclofenac]

PMID:24552538

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

Nqo2

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

multiple interactions

NQO2 protein results in increased reduction of and results in decreased glutathionylation of 4'-hydroxydiclofenac

PMID:29281794

NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320

Nr3c1

nuclear receptor subfamily 3, group C, member 1

multiple interactions

4'-hydroxydiclofenac binds to and affects the activity of NR3C1 protein

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

Tnf

tumor necrosis factor

increases response to substance
multiple interactions

EXP
ISO

TNF protein results in increased susceptibility to 4'-hydroxydiclofenac
4'-hydroxydiclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]