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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:colesevelam hydrochloride
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Accession:CHEBI:59599 term browser browse the term
Definition:The hydrochloride of colesevelam. It is used as an orally administered bile acid sequestrant to reduce the amount of cholesterol and certain fatty substances in the blood.
Synonyms:related_synonym: colesevelam HCl
 xref: CAS:182815-44-7;   DrugBank:DB00930;   KEGG:D03582
 xref_mesh: MESH:C107058
 xref: Patent:US5693675;   Patent:WO9534585


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colesevelam hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein decreases expression ISO Colesevelam Hydrochloride results in decreased expression of CRP protein CTD PMID:16616026 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression		 ISO Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA]
Colesevelam Hydrochloride results in increased expression of HMGCR mRNA		 CTD PMID:22120639 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Colesevelam Hydrochloride results in increased expression of LDLR mRNA CTD PMID:22120639 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      application 19713
        pharmaceutical 19548
          drug 19548
            antilipemic drug 9326
              anticholesteremic drug 3946
                colesevelam hydrochloride 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19669
                        hydrogen molecular entity 19651
                          hydrides 19162
                            inorganic hydride 18183
                              pnictogen hydride 18173
                                nitrogen hydride 18086
                                  ammonium 8325
                                    ammonium ion derivative 8320
                                      ammonium compound 5207
                                        organoammonium salt 672
                                          quaternary ammonium salt 554
                                            colesevelam 3
                                              colesevelam hydrochloride 3
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