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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.14.13.132 (squalene monooxygenase) inhibitor
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Accession:CHEBI:59285 term browser browse the term
Definition:An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of squalene monooxygenase (EC 1.14.13.132).
Synonyms:related_synonym: EC 1.14.13.132 (squalene monooxygenase) inhibitors;   squalene 2,3-oxidocyclase inhibitor;   squalene 2,3-oxidocyclase inhibitors;   squalene epoxidase inhibitor;   squalene epoxidase inhibitors;   squalene hydroxylase inhibitor;   squalene hydroxylase inhibitors;   squalene monooxygenase inhibitor;   squalene monooxygenase inhibitors;   squalene oxydocyclase inhibitor;   squalene oxydocyclase inhibitors;   squalene-2,3-epoxidase inhibitor;   squalene-2,3-epoxidase inhibitors;   squalene-2,3-epoxide cyclase inhibitor;   squalene-2,3-epoxide cyclase inhibitors



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amorolfine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:68,820,330...68,824,906 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO amorolfine inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; amorolfine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:15,989,066...15,991,263 JBrowse link
G Il4 interleukin 4 multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; amorolfine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:23688403 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO amorolfine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO amorolfine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:24471457 NCBI chr 9:56,911,522...56,951,926 JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,723,990...24,728,419 JBrowse link
butenafine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:68,820,330...68,824,906 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]]; butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:15,989,066...15,991,263 JBrowse link
G Il4 interleukin 4 multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; butenafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:23688403 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO butenafine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased activity of STAT1 protein]]; butenafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:24471457 NCBI chr 9:56,911,522...56,951,926 JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,723,990...24,728,419 JBrowse link
naftifine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO naftifine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424 JBrowse link
terbinafine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein] CTD PMID:16784723 NCBI chr10:67,503,077...67,504,875 JBrowse link
G Ccl27 C-C motif chemokine ligand 27 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein] CTD PMID:16784723 NCBI chr 5:56,941,402...56,948,511 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein] CTD PMID:16784723 PMID:23688403 NCBI chr10:68,820,330...68,824,906 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Terbinafine inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Terbinafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:15,989,066...15,991,263 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Terbinafine results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Terbinafine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
ISO [terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] CTD PMID:24894748 NCBI chr 7:115,762,662...115,771,832 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases response to substance
increases expression
ISO CYP3A4 protein results in increased susceptibility to Terbinafine
Terbinafine results in increased expression of CYP3A4 mRNA
CTD PMID:21540358 PMID:36356836 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO terbinafine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242 JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
decreases secretion
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; terbinafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:11886533 PMID:15284827 PMID:23688403 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion
decreases expression
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Terbinafine results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Terbinafine results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Terbinafine results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Terbinafine results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Terbinafine results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Terbinafine results in decreased secretion of IL5 protein]
terbinafine results in decreased secretion of IL5 protein
terbinafine results in decreased expression of IL5 mRNA
CTD PMID:11886533 PMID:15284827 NCBI chr10:38,375,132...38,378,003 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO terbinafine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO terbinafine results in increased phosphorylation of MAPK1 protein CTD PMID:20816994 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO terbinafine results in increased phosphorylation of MAPK3 protein CTD PMID:20816994 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO terbinafine results in decreased expression of MMP2 mRNA CTD PMID:17172416 NCBI chr19:30,327,643...30,355,856 JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO terbinafine results in decreased expression of MMP9 mRNA CTD PMID:17172416 NCBI chr 3:174,103,474...174,111,434 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to terbinafine CTD PMID:21540358 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions
increases response to substance
ISO PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER2 protein results in increased susceptibility to terbinafine
CTD PMID:16784723 NCBI chr15:18,215,013...18,228,714 JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions
increases response to substance
ISO PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER3 protein results in increased susceptibility to terbinafine
CTD PMID:16784723 NCBI chr 2:246,606,131...246,750,970 JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO terbinafine results in decreased phosphorylation of PTK2 protein CTD PMID:17172416 NCBI chr 7:107,015,730...107,220,865 JBrowse link
G Pxn paxillin decreases phosphorylation ISO terbinafine results in decreased phosphorylation of PXN protein CTD PMID:17172416 NCBI chr12:41,060,791...41,107,952 JBrowse link
G Rhoa ras homolog family member A increases localization ISO terbinafine results in increased localization of RHOA protein CTD PMID:17172416 NCBI chr 8:117,870,548...117,904,303 JBrowse link
G Rhob ras homolog family member B decreases expression ISO terbinafine results in decreased expression of RHOB protein CTD PMID:17172416 NCBI chr 6:31,363,752...31,365,926 JBrowse link
G Rhoc ras homolog family member C increases localization ISO terbinafine results in increased localization of RHOC protein CTD PMID:17172416 NCBI chr 2:192,287,065...192,293,292 JBrowse link
G RT1-CE16 RT1 class I, locus CE16 affects response to substance ISO HLA-A gene polymorphism affects the susceptibility to Terbinafine CTD PMID:28043905 NCBI chr20:3,261,656...3,265,548 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO terbinafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:24471457 NCBI chr 9:56,911,522...56,951,926 JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Terbinafine inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; Terbinafine promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; U 0126 inhibits the reaction [Terbinafine results in increased expression of TNF protein]
terbinafine results in increased expression of TNF protein
CTD PMID:16784723 PMID:20816994 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,723,990...24,728,419 JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        biochemical role 19577
          enzyme inhibitor 18779
            EC 1.* (oxidoreductase) inhibitor 17563
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 15998
                EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor 10290
                  EC 1.14.13.132 (squalene monooxygenase) inhibitor 30
                    amorolfine 7
                    amorolfine hydrochloride 0
                    butenafine + 7
                    butenafine hydrochloride 0
                    naftifine 1
                    terbinafine 29
                    terbinafine hydrochloride 0
paths to the root