acetate salt - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	acetate salt	go back to main search page
Accession:	CHEBI:59230	browse the term
Definition:	Any salt prepared using acetic acid as the acid component.
Synonyms:	related_synonym:	acetate salts

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Genes (213)

ammonium acetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase

increases activity

ammonium acetate results in increased activity of ADA protein

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

adrenoceptor alpha 1A

decreases expression

ammonium acetate results in decreased expression of ADRA1A mRNA

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

adenosine monophosphate deaminase 2

increases activity

ammonium acetate results in increased activity of AMPD2 protein

NCBI chr 2:195,707,609...195,720,454
Ensembl chr 2:195,707,610...195,720,271

G

adenosine monophosphate deaminase 3

increases activity

ammonium acetate results in increased activity of AMPD3 protein

NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887

G

argininosuccinate lyase

increases activity

ammonium acetate results in increased activity of ASL protein

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

argininosuccinate synthase 1

increases activity

ammonium acetate results in increased activity of ASS1 protein

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ATPase Na+/K+ transporting subunit alpha 1

decreases expression

ammonium acetate results in decreased expression of ATP1A1 protein

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

ammonium acetate results in decreased expression of ATP1A2 protein

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit alpha 3

decreases expression

ammonium acetate results in decreased expression of ATP1A3 protein

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

decreases expression

ammonium acetate results in decreased expression of ATP2A2 protein

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATPase plasma membrane Ca2+ transporting 2

decreases expression

ammonium acetate results in decreased expression of ATP2B2 protein

NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665

G

ATPase plasma membrane Ca2+ transporting 3

decreases expression

ammonium acetate results in decreased expression of ATP2B3 protein

NCBI chr X:151,216,483...151,289,069
Ensembl chr X:151,216,507...151,286,775

G

ATPase plasma membrane Ca2+ transporting 4

decreases expression

ammonium acetate results in decreased expression of ATP2B4 protein

NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246

G

calreticulin

increases expression
decreases expression

ammonium acetate results in increased expression of CALR protein
ammonium acetate results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

catalase

increases activity
decreases activity
multiple interactions

ammonium acetate results in increased activity of CAT protein
ammonium acetate results in decreased activity of CAT protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of CAT protein]

PMID:12885441 PMID:15945352

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

CD74 molecule

increases expression

ammonium acetate results in increased expression of CD74 mRNA; ammonium acetate results in increased expression of CD74 protein

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

CD8 subunit alpha

increases expression

ammonium acetate results in increased expression of CD8A mRNA

NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040

G

cholinergic receptor nicotinic epsilon subunit

increases expression

ammonium acetate results in increased expression of CHRNE mRNA

NCBI chr10:55,331,211...55,339,923
Ensembl chr10:55,331,212...55,335,530

G

claudin 10

decreases expression

ammonium acetate results in decreased expression of CLDN10 mRNA; ammonium acetate results in decreased expression of CLDN10 protein

NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526

G

corticotropin releasing hormone receptor 2

increases expression

ammonium acetate results in increased expression of CRHR2 mRNA

NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904

G

G protein-coupled receptor 83

increases expression

ammonium acetate results in increased expression of GPR83 mRNA

NCBI chr 8:11,693,540...11,704,028
Ensembl chr 8:11,693,540...11,704,028

G

glutamate ionotropic receptor AMPA type subunit 4

decreases expression

ammonium acetate results in decreased expression of GRIA4 mRNA; ammonium acetate results in decreased expression of GRIA4 protein

NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions
decreases expression

Allopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein]

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

ammonium acetate results in decreased expression of GRIN2B protein

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glutamate metabotropic receptor 6

increases expression

ammonium acetate results in increased expression of GRM6 mRNA

NCBI chr10:35,167,985...35,182,717
Ensembl chr10:35,167,985...35,182,717

G

heme oxygenase 1

increases expression

ammonium acetate results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

intercellular adhesion molecule 1

increases expression

ammonium acetate results in increased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 beta

multiple interactions
increases expression

[Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Ibuprofen inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression
multiple interactions

ammonium acetate results in increased expression of IL6 mRNA
[Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Ibuprofen inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inositol 1,4,5-trisphosphate receptor, type 1

decreases expression

ammonium acetate results in decreased expression of ITPR1

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

G

luteinizing hormone subunit beta

increases expression

ammonium acetate results in increased expression of LHB mRNA

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

myelin-associated glycoprotein

increases expression

ammonium acetate results in increased expression of MAG mRNA

NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656

G

monoamine oxidase A

increases activity
multiple interactions

ammonium acetate results in increased activity of MAOA protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein]

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

neuropeptide Y receptor Y1

decreases expression

ammonium acetate results in decreased expression of NPY1R mRNA

NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759

G

poly (ADP-ribose) polymerase 1

increases expression
multiple interactions

ammonium acetate results in increased expression of PARP1 protein
Cycloheximide inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein]; Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

protein phosphatase 1 catalytic subunit gamma

increases expression

ammonium acetate results in increased expression of PPP1CC protein

NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553

G

RT1 class Ia, locus A1

decreases expression

ammonium acetate results in decreased expression of RT1-A1 mRNA

NCBI chr20:4,905,309...4,914,593

G

RT1 class Ia, locus A2

decreases expression

ammonium acetate results in decreased expression of RT1-A2 mRNA

NCBI chr20:4,870,939...4,910,183

G

RT1 class I, locus CE10

decreases expression

ammonium acetate results in decreased expression of RT1-CE10 mRNA

NCBI chr20:3,377,284...3,380,301

G

solute carrier family 8 member A2

decreases expression

ammonium acetate results in decreased expression of SLC8A2 protein

NCBI chr 1:76,816,583...76,852,928
Ensembl chr 1:76,808,725...76,847,072

G

superoxide dismutase 2

decreases activity
multiple interactions

ammonium acetate results in decreased activity of SOD2 protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

xanthine dehydrogenase

affects activity
multiple interactions

ammonium acetate affects the activity of XDH protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate affects the activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

cobalt(II) acetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hypoxia inducible factor 1 subunit alpha

increases expression

cobalt(II) acetate results in increased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

lead tetraacetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

decreases expression

lead tetraacetate results in decreased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

microtubule-associated protein tau

decreases expression

lead tetraacetate results in decreased expression of MAPT mRNA

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

neurexin 1

decreases expression

lead tetraacetate results in decreased expression of NRXN1 mRNA

NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710

G

prion protein

decreases expression

lead tetraacetate results in decreased expression of PRNP mRNA

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

synaptophysin

decreases expression

lead tetraacetate results in decreased expression of SYP mRNA

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

tubulin, beta 3 class III

decreases expression

lead tetraacetate results in decreased expression of TUBB3 mRNA

NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243

thallium(I) acetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkB homolog 5, RNA demethylase

multiple interactions
decreases expression

3-deazaadenosine inhibits the reaction [thallium acetate results in decreased expression of ALKBH5 protein]; ALKBH5 protein affects the reaction [thallium acetate results in increased expression of ATP13A3 protein]

NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331

G

ATPase 13A3

increases expression
multiple interactions
increases stability

thallium acetate results in increased expression of ATP13A3 protein
3-deazaadenosine inhibits the reaction [thallium acetate results in increased expression of and results in increased methylation of ATP13A3 mRNA]; 3-deazaadenosine inhibits the reaction [thallium acetate results in increased expression of ATP13A3 protein]; ALKBH5 protein affects the reaction [thallium acetate results in increased expression of ATP13A3 protein]; METTL14 protein affects the reaction [thallium acetate results in increased expression of ATP13A3 protein]; METTL3 protein affects the reaction [thallium acetate results in increased expression of ATP13A3 protein]; thallium acetate results in increased expression of and results in increased methylation of ATP13A3 mRNA
thallium acetate results in increased stability of ATP13A3 mRNA

NCBI chr11:70,364,998...70,442,005
Ensembl chr11:70,365,322...70,441,235

G

H2A.X variant histone

increases expression

thallium acetate results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit

multiple interactions
increases expression

3-deazaadenosine inhibits the reaction [thallium acetate results in increased expression of METTL14 protein]; METTL14 protein affects the reaction [thallium acetate results in increased expression of ATP13A3 protein]

NCBI chr 2:211,530,598...211,546,845
Ensembl chr 2:211,530,602...211,546,821

G

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

multiple interactions
increases expression

3-deazaadenosine inhibits the reaction [thallium acetate results in increased expression of METTL3 protein]; METTL3 protein affects the reaction [thallium acetate results in increased expression of ATP13A3 protein]

NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041

G

superoxide dismutase 1

decreases activity

thallium acetate results in decreased activity of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

zinc acetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of AGL mRNA
Zinc Acetate results in decreased expression of AGL mRNA

NCBI chr 2:204,705,053...204,760,966
Ensembl chr 2:204,705,053...204,760,828

G

aminolevulinate dehydratase

multiple interactions
increases activity

[Zinc Acetate results in increased activity of ALAD protein] which results in increased chemical synthesis of Porphobilinogen; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

aldehyde dehydrogenase 5 family, member A1

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of ALDH5A1 mRNA]

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

aldehyde dehydrogenase 6 family, member A1

multiple interactions
increases expression

Zinc Acetate inhibits the reaction [motexafin gadolinium results in decreased expression of ALDH6A1 mRNA]
Zinc Acetate results in increased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

Rho GTPase activating protein 17

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ARHGAP17 mRNA
Zinc Acetate results in decreased expression of ARHGAP17 mRNA

NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854

G

activating transcription factor 3

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of ATF3 mRNA]

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATM serine/threonine kinase

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of ATM mRNA]

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase copper transporting beta

increases response to substance
multiple interactions

ATP7B gene mutant form results in increased susceptibility to Zinc Acetate
[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of ABCB11 mRNA; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of NR0B2 mRNA; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of RXRA mRNA

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

ATR serine/threonine kinase

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ATR mRNA
Zinc Acetate results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

BTB domain and CNC homolog 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BACH1 mRNA
Zinc Acetate results in increased expression of BACH1 mRNA

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

BAG cochaperone 3

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of BAG3 mRNA]

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

Bcl-2 binding component 3

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein]

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

baculoviral IAP repeat-containing 5

increases expression
multiple interactions

Zinc Acetate results in increased expression of BIRC5 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of BIRC5 mRNA]

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BCL2 interacting protein 3

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3 mRNA
Zinc Acetate results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 interacting protein 3 like

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3L mRNA
Zinc Acetate results in increased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

basigin

multiple interactions

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BSG protein]

NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387

G

calnexin

increases expression
multiple interactions

Zinc Acetate results in increased expression of CANX mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

caspase 3

multiple interactions
decreases expression

[Taurine co-treated with Zinc Acetate] inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
Zinc Acetate results in decreased expression of CASP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CASP3 mRNA

PMID:16357179 PMID:26335259

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

core-binding factor subunit beta

increases expression
multiple interactions

Zinc Acetate results in increased expression of CBFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CBFB mRNA

NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751

G

cyclin B1

multiple interactions

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCNB1 protein]

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin J

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CCNJ mRNA
Zinc Acetate results in decreased expression of CCNJ mRNA

NCBI chr 1:239,659,588...239,677,367

G

cell division cycle 16

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC16 mRNA
Zinc Acetate results in decreased expression of CDC16 mRNA

NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550

G

cell division cycle 25C

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDC25C mRNA
Zinc Acetate results in increased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 27

increases expression
multiple interactions

Zinc Acetate results in increased expression of CDC27 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CDC27 mRNA

NCBI chr10:89,400,720...89,449,816
Ensembl chr10:89,400,940...89,449,736

G

cell division cycle 5-like

decreases expression
multiple interactions

Zinc Acetate results in decreased expression of CDC5L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC5L mRNA

NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450

G

cell division cycle associated 2

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDCA2 mRNA
Zinc Acetate results in decreased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cyclin-dependent kinase 19

increases expression

Zinc Acetate results in increased expression of CDK19 mRNA

NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628

G

cyclin dependent kinase 2

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of CDK2 mRNA]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDKN1B mRNA
Zinc Acetate results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cystathionine gamma-lyase

increases expression
multiple interactions

Zinc Acetate results in increased expression of CTH mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

cullin 3

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA
Zinc Acetate results in decreased expression of CUL3 mRNA

NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462

G

C-X-C motif chemokine ligand 1

increases secretion

Zinc Acetate results in increased secretion of CXCL1 protein

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 3

increases secretion

Zinc Acetate results in increased secretion of CXCL1 protein

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome b5 reductase 1

increases expression
multiple interactions

Zinc Acetate results in increased expression of CYB5R1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CYB5R1 mRNA

NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458

G

death-associated protein kinase 3

increases expression
multiple interactions

Zinc Acetate results in increased expression of DAPK3 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DAPK3 mRNA]

NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DDIT3 mRNA]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of DDIT4 mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of DDIT4 mRNA]

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

death effector domain containing 2

increases expression
multiple interactions

Zinc Acetate results in increased expression of DEDD2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DEDD2 mRNA]

NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714

G

DNA fragmentation factor subunit beta

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of DFFB mRNA
Zinc Acetate results in decreased expression of DFFB mRNA

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

7-dehydrocholesterol reductase

decreases expression

Zinc Acetate results in decreased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

DnaJ heat shock protein family (Hsp40) member B1

decreases expression
multiple interactions

Zinc Acetate results in decreased expression of DNAJB1 mRNA
motexafin gadolinium inhibits the reaction [Zinc Acetate results in decreased expression of DNAJB1 mRNA]

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B4

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB4 mRNA
Zinc Acetate results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member B6

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB6 mRNA
Zinc Acetate results in increased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member C3

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of DNAJC3 mRNA]

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

dopamine receptor D1

multiple interactions

Zinc Acetate inhibits the reaction [SCH 23390 binds to DRD1 protein]

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions

Zinc Acetate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dual specificity phosphatase 1

multiple interactions

[Taurine co-treated with Zinc Acetate] results in increased expression of DUSP1 mRNA; [Taurine co-treated with Zinc Acetate] results in increased expression of DUSP1 protein

NCBI chr10:16,680,478...16,683,275

G

E2F transcription factor 1

increases expression
multiple interactions

Zinc Acetate results in increased expression of E2F1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F3 mRNA
Zinc Acetate results in increased expression of E2F3 mRNA

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

egl-9 family hypoxia-inducible factor 1

increases expression
multiple interactions

Zinc Acetate results in increased expression of EGLN1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of EGLN1 mRNA

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

elongator acetyltransferase complex subunit 1

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ELP1 mRNA
Zinc Acetate results in decreased expression of ELP1 mRNA

NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762

G

enolase 1

increases expression

Zinc Acetate results in increased expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

Fas associated via death domain

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FADD mRNA
Zinc Acetate results in decreased expression of FADD mRNA

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas apoptotic inhibitory molecule

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FAIM mRNA
Zinc Acetate results in decreased expression of FAIM mRNA

NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562

G

family with sequence similarity 162, member A

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FAM162A mRNA
Zinc Acetate results in increased expression of FAM162A mRNA

NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239

G

fatty acid synthase

decreases expression

Zinc Acetate results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

forkhead box O3

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA
Zinc Acetate results in increased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

glutamate cysteine ligase, modifier subunit

increases expression
multiple interactions

Zinc Acetate results in increased expression of GCLM mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutaminase

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GLS mRNA
Zinc Acetate results in decreased expression of GLS mRNA

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

G protein-coupled receptor 146

increases expression

Zinc Acetate results in increased expression of GPR146 mRNA

NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206

G

glutamic--pyruvic transaminase 2

increases expression

Zinc Acetate results in increased expression of GPT2 mRNA

NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610

G

glutathione peroxidase 1

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions
decreases activity
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GSR mRNA
Zinc Acetate results in decreased activity of GSR protein
Zinc Acetate results in increased expression of GSR mRNA

PMID:16357179 PMID:17382203

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

general transcription factor IIIC subunit 2

increases expression

Zinc Acetate results in increased expression of GTF3C2 mRNA

NCBI chr 6:25,196,439...25,221,338
Ensembl chr 6:25,197,268...25,220,490

G

HMG-box transcription factor 1

increases expression
multiple interactions

Zinc Acetate results in increased expression of HBP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HBP1 mRNA

NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HIF1A protein
Zinc Acetate results in increased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hypoxia inducible lipid droplet-associated

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HILPDA mRNA
Zinc Acetate results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

homeodomain interacting protein kinase 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HIPK1 mRNA]

NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902

G

helicase-like transcription factor

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of HLTF mRNA
Zinc Acetate results in decreased expression of HLTF mRNA

NCBI chr 2:102,549,724...102,609,492
Ensembl chr 2:102,549,724...102,609,327

G

heme oxygenase 1

multiple interactions
increases expression

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HMOX1 protein; motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HMOX1 mRNA]
[Taurine co-treated with Zinc Acetate] results in increased expression of HMOX1 protein

PMID:16357179 PMID:26335259

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

harakiri, BCL2 interacting protein

increases expression
multiple interactions

Zinc Acetate results in increased expression of HRK mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HRK mRNA

NCBI chr12:38,387,484...38,409,652

G

heat shock protein 90 alpha family class B member 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSP90AB1 mRNA
Zinc Acetate results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1A mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1A mRNA]

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1B mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1B mRNA]

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 4

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4 mRNA
Zinc Acetate results in increased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 4 like

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4L mRNA
Zinc Acetate results in increased expression of HSPA4L mRNA

NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084

G

heat shock protein family B (small) member 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPB1 mRNA]

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPD1 mRNA]

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family H (Hsp110) member 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPH1 mRNA]

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

intercellular adhesion molecule 1

multiple interactions
increases expression

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]; [Zinc Acetate results in increased phosphorylation of NFKBIA protein] inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]; MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 2

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA
Zinc Acetate results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IKBKE mRNA
Zinc Acetate results in increased expression of IKBKE mRNA

NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143

G

interleukin 10

increases secretion

Zinc Acetate results in increased secretion of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

[Taurine co-treated with Zinc Acetate] results in decreased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases secretion

Zinc Acetate results in increased secretion of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 7

increases secretion

Zinc Acetate results in increased secretion of IL7 protein

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

G

interferon regulatory factor 2 binding protein 2

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IRF2BP2 mRNA
Zinc Acetate results in increased expression of IRF2BP2 mRNA

NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of JUND mRNA
Zinc Acetate results in increased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

lysine demethylase 3A

increases expression

Zinc Acetate results in increased expression of KDM3A mRNA

NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073

G

mitogen-activated protein kinase 8

multiple interactions

[Taurine co-treated with Zinc Acetate] results in decreased expression of MAPK8 protein modified form

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

[Taurine co-treated with Zinc Acetate] results in decreased expression of MAPK9 protein modified form

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein tau

multiple interactions

[Zinc Acetate results in decreased abundance of Copper] which results in decreased phosphorylation of MAPT protein

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

MDM2 proto-oncogene

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA]

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

MOB kinase activator 1A

increases expression
multiple interactions

Zinc Acetate results in increased expression of MOB1A mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MOB1A mRNA]

NCBI chr 4:115,831,581...115,848,561
Ensembl chr 4:115,831,551...115,848,561
Ensembl chr 1:115,831,551...115,848,561

G

metallothionein 1

increases expression

Zinc Acetate results in increased expression of MT1 protein

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 1, pseudogene 3

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of MT1E mRNA
Zinc Acetate results in increased expression of MT1E mRNA

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2, pseudogene 1

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT1HL1 mRNA]

NCBI chr20:3,159,037...3,159,409
Ensembl chr 5:119,728,811...119,730,073

G

metallothionein 2A

increases expression
multiple interactions

Zinc Acetate results in increased expression of MT2 mRNA; Zinc Acetate results in increased expression of MT2 protein
Zinc Acetate results in increased expression of MT2A mRNA
motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT2A mRNA]

PMID:8876661 PMID:15306638 PMID:16357179

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

MYD88, innate immune signal transduction adaptor

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of MYD88 mRNA; MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of CXCL8 protein]; MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]
Zinc Acetate results in decreased expression of MYD88 mRNA

PMID:16357179 PMID:24080332

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NAD kinase

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NADK mRNA
Zinc Acetate results in increased expression of NADK mRNA

NCBI chr 5:166,145,708...166,176,328
Ensembl chr 5:166,145,481...166,176,322

G

neurofibromin 1

increases expression
multiple interactions

Zinc Acetate results in increased expression of NF1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NF1 mRNA

NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658

G

NFKB inhibitor alpha

increases degradation
multiple interactions
increases phosphorylation

Zinc Acetate results in increased degradation of NFKBIA protein
[Zinc Acetate results in increased phosphorylation of NFKBIA protein] inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]

PMID:21974847 PMID:24080332

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nischarin

decreases expression

Zinc Acetate results in decreased expression of NISCH mRNA

NCBI chr16:6,364,370...6,400,675
Ensembl chr16:6,364,374...6,400,668

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group D, member 2

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of NR1D2 mRNA]

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

prolyl 4-hydroxylase subunit beta

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of P4HB mRNA]

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

programmed cell death 11

decreases expression

Zinc Acetate results in decreased expression of PDCD11 mRNA

NCBI chr 1:245,980,840...246,021,999
Ensembl chr 1:245,980,880...246,021,999

G

programmed cell death 4

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PDCD4 mRNA
Zinc Acetate results in increased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

programmed cell death 5

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PDCD5 mRNA
Zinc Acetate results in decreased expression of PDCD5 mRNA

NCBI chr 1:88,305,869...88,311,200
Ensembl chr 1:88,305,869...88,311,200

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB3 mRNA
Zinc Acetate results in increased expression of PFKFB3 mRNA

NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB4 mRNA
Zinc Acetate results in increased expression of PFKFB4 mRNA

NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634

G

phosphofructokinase, muscle

multiple interactions

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PFKM protein]

NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192

G

phosphoglycerate kinase 1

increases expression
multiple interactions

Zinc Acetate results in increased expression of PGK1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PGK1 mRNA]

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

putative homeodomain transcription factor 2

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PHTF2 mRNA]

NCBI chr 4:14,215,190...14,330,549
Ensembl chr 4:14,215,263...14,330,513

G

protein inhibitor of activated STAT, 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PIAS1 mRNA]

NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905

G

phosphoinositide-3-kinase interacting protein 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PIK3IP1 mRNA
Zinc Acetate results in increased expression of PIK3IP1 mRNA

NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression
multiple interactions

Zinc Acetate results in increased expression of PMAIP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

protein kinase cAMP-activated catalytic subunit beta

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PRKACB mRNA
Zinc Acetate results in increased expression of PRKACB mRNA

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

G

protein kinase C, delta

decreases expression

Zinc Acetate results in decreased expression of PRKCD mRNA

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase D2

decreases expression

Zinc Acetate results in decreased expression of PRKD2 mRNA

NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376

G

protein kinase, DNA-activated, catalytic subunit

increases expression

Zinc Acetate results in increased expression of PRKDC mRNA

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

peptidyl-tRNA hydrolase 2

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PTRH2 mRNA
Zinc Acetate results in decreased expression of PTRH2 mRNA

NCBI chr10:71,505,113...71,515,297
Ensembl chr10:71,504,956...71,515,398

G

PTTG1 regulator of sister chromatid separation, securin

multiple interactions

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTTG1 protein]

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

RB transcriptional corepressor 1

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RB1 mRNA
Zinc Acetate results in decreased expression of RB1 mRNA

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RCC1 and BTB domain containing protein 2

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RCBTB2 mRNA
Zinc Acetate results in decreased expression of RCBTB2 mRNA

NCBI chr15:48,319,809...48,364,441
Ensembl chr15:48,323,866...48,383,750

G

RELB proto-oncogene, NF-kB subunit

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of RELB mRNA
Zinc Acetate results in increased expression of RELB mRNA

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

retinoid X receptor alpha

multiple interactions

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of RXRA mRNA

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

S-adenosylmethionine sensor upstream of mTORC1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SAMTOR mRNA
Zinc Acetate results in increased expression of SAMTOR mRNA

NCBI chr 4:41,881,630...41,945,472
Ensembl chr 4:41,879,993...41,945,539

G

selenoprotein W

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SELENOW mRNA
Zinc Acetate results in increased expression of SELENOW mRNA

NCBI chr 1:76,599,441...76,604,514
Ensembl chr 1:76,598,779...76,604,724
Ensembl chr 1:76,598,779...76,604,724

G

sestrin 2

multiple interactions
increases expression

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA; [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]
Zinc Acetate results in increased expression of SESN2 mRNA

PMID:16357179 PMID:20530418

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

solute carrier family 16 member 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC16A1 mRNA]

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 16 member 3

multiple interactions

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of SLC16A3 protein]

NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562

G

solute carrier family 16, member 6

increases expression
multiple interactions

Zinc Acetate results in increased expression of SLC16A6 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC16A6 mRNA

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 1 member 4

increases expression
multiple interactions

Zinc Acetate results in increased expression of SLC1A4 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC1A4 mRNA]

NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 2 member 1

multiple interactions

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 protein]

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 30 member 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC30A1 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC30A1 mRNA]

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 31 member 1

increases expression

Zinc Acetate results in increased expression of SLC31A1 mRNA

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 38, member 2

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC38A2 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC38A2 mRNA]

NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 39 member 10

affects expression
multiple interactions

Zinc Acetate affects the expression of SLC39A10 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A10 mRNA

NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325

G

solute carrier family 39 member 14

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A14 mRNA
Zinc Acetate results in increased expression of SLC39A14 mRNA

NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524

G

solute carrier family 39, member 9

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC39A9 mRNA
Zinc Acetate results in increased expression of SLC39A9 mRNA

NCBI chr 6:100,291,537...100,330,419
Ensembl chr 6:100,291,573...100,330,408

G

solute carrier family 3 member 2

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC3A2 mRNA
Zinc Acetate results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 43 member 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC43A1 mRNA
Zinc Acetate results in increased expression of SLC43A1 mRNA

NCBI chr 3:69,920,586...69,946,768
Ensembl chr 3:69,920,649...69,946,768

G

solute carrier family 7 member 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A1 mRNA
Zinc Acetate results in increased expression of SLC7A1 mRNA

NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849

G

solute carrier family 7 member 11

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A11 mRNA
Zinc Acetate results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA4 mRNA
Zinc Acetate results in decreased expression of SMARCA4 mRNA

NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975

G

SNF2 related chromatin remodeling ATPase 5

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA5 mRNA
Zinc Acetate results in decreased expression of SMARCA5 mRNA

NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594

G

superoxide dismutase 1

multiple interactions

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

Sp1 transcription factor

increases expression

Zinc Acetate results in increased expression of SP1 mRNA

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

T-cell activation RhoGTPase activating protein

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TAGAP mRNA
Zinc Acetate results in increased expression of TAGAP mRNA

NCBI chr 1:47,170,725...47,179,705
Ensembl chr 1:47,170,725...47,179,792

G

transferrin receptor

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of TFRC mRNA]

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

TNF alpha induced protein 8

decreases expression
multiple interactions

Zinc Acetate results in decreased expression of TNFAIP8 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFAIP8 mRNA

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 17

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFRSF17 mRNA
Zinc Acetate results in decreased expression of TNFRSF17 mRNA

NCBI chr10:4,301,023...4,306,889
Ensembl chr10:4,301,038...4,306,788

G

TNF receptor superfamily member 1A

increases expression
multiple interactions

Zinc Acetate results in increased expression of TNFRSF1A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 8

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of TNFSF8 mRNA]

NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421

G

TNFAIP3 interacting protein 2

decreases expression

Zinc Acetate results in decreased expression of TNIP2 mRNA

NCBI chr14:76,228,350...76,245,553
Ensembl chr14:76,228,371...76,275,265

G

tumor protein p53

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein; Acetylcysteine inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tribbles pseudokinase 3

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TRIB3 mRNA
Zinc Acetate results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

thioredoxin reductase 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TXNRD1 mRNA
Zinc Acetate results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

UDP glucuronosyltransferase 2 family, polypeptide B1

multiple interactions

[Taurine co-treated with Zinc Acetate] results in increased expression of UGT2B1 mRNA

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

vascular endothelial growth factor A

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of VEGFA mRNA
Zinc Acetate results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

von Hippel-Lindau tumor suppressor

increases expression
multiple interactions

Zinc Acetate results in increased expression of VHL mRNA
motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of VHL mRNA]

NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19899
chemical entity	19897
molecular entity	19897
ion	17101
cation	16892
salt	16302
organic salt	3331
acetate salt	213
(2S)-2-Ethylhexyl acetate	0
1-dodecylguanidine acetate	0
L-arginyl-L-glutamic acid monoacetate	0
[dodecanoyl(methyl)amino]acetate	0
ammonium acetate	42
barium acetate	0
caspofungin acetate	0
ceftaroline fosamil acetate +	0
cetrorelix acetate	0
chlorhexidine acetate	0
cobalt(II) acetate	1
desmopressin acetate (anhydrous) +	0
flecainide acetate	0
histrelin acetate	0
icatibant acetate	0
lead tetraacetate	6
leuprolide acetate	0
lithium acetate	0
motixafortide acetate	0
nafarelin acetate +	0
peginesatide acetate	0
praseodymium acetate	0
rezafungin acetate	0
saxitoxin acetate	0
thallium(I) acetate	6
tris acetate	0
zinc acetate	165
Path 2
Term	Annotations
CHEBI ontology	19899
subatomic particle	19897
composite particle	19897
hadron	19897
baryon	19897
nucleon	19897
atomic nucleus	19897
atom	19897
group	19850
polyatomic entity	19849
heteroatomic molecular entity	19806
salt	16302
organic salt	3331
acetate salt	213
(2S)-2-Ethylhexyl acetate	0
1-dodecylguanidine acetate	0
L-arginyl-L-glutamic acid monoacetate	0
[dodecanoyl(methyl)amino]acetate	0
ammonium acetate	42
barium acetate	0
caspofungin acetate	0
ceftaroline fosamil acetate +	0
cetrorelix acetate	0
chlorhexidine acetate	0
cobalt(II) acetate	1
desmopressin acetate (anhydrous) +	0
flecainide acetate	0
histrelin acetate	0
icatibant acetate	0
lead tetraacetate	6
leuprolide acetate	0
lithium acetate	0
motixafortide acetate	0
nafarelin acetate +	0
peginesatide acetate	0
praseodymium acetate	0
rezafungin acetate	0
saxitoxin acetate	0
thallium(I) acetate	6
tris acetate	0
zinc acetate	165

paths to the root