The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Felodipine results in decreased activity of ABCB11 protein Felodipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of NFKB1 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of RELA protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF protein]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 protein]
Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of CCL2 protein]
Felodipine results in decreased activity of CYP2C8 protein Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine]
deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine]; Felodipine results in increased expression of and results in decreased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine] Felodipine results in increased expression of CYP3A4 mRNA
Felodipine inhibits the reaction [Fructose results in increased expression of IL18 mRNA]; Felodipine inhibits the reaction [Fructose results in increased expression of IL18 protein]
Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of NCF1 protein]
Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of NFKB1 protein]
Felodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; Felodipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] Felodipine results in increased activity of NR1H4 protein
Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of RAC1 protein]
Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which affects the activity of and affects the localization of RELA protein]
Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of TNF protein]
Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 mRNA]; Felodipine inhibits the reaction [[APOE gene mutant form affects the susceptibility to Cholesterol, Dietary] which results in increased expression of VCAM1 protein]
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