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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hexachlorophene
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Accession:CHEBI:5693 term browser browse the term
Definition:An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.
Synonyms:exact_synonym: 2,2'-methylenebis(3,4,6-trichlorophenol)
 related_synonym: 2,2',3,3',5,5'-hexachloro-6,6'-dihydroxydiphenylmethane;   2,2'-dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane;   2,2'-methanediylbis(3,4,6-trichlorophenol);   Acigena;   Almederm;   Armohex;   Distodin;   Esaclorofene;   Exofene;   Formula=C13H6Cl6O2;   Gamophen;   Gamophene;   Germa-medica;   Hexa-Germ;   Hexabalm;   Hexafen;   Hexascrub;   Hexide;   InChI=1S/C13H6Cl6O2/c14-6-2-8(16)12(20)4(10(6)18)1-5-11(19)7(15)3-9(17)13(5)21/h2-3,20-21H,1H2;   InChIKey=ACGUYXCXAPNIKK-UHFFFAOYSA-N;   Nabac;   Phiso-Scrub;   Phisodan;   SMILES=Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl;   Septi-Soft;   Septisol;   Septofen;   Solu-Heks;   Soy-Dome;   Staphene O;   Ster-Zac;   Steral;   Steraskin;   Surgi-Cen;   Surgi-cin;   Surofene;   Tersaseptic;   Turgex;   bis(2-hydroxy-3,5,6-trichlorophenyl)methane;   bis(3,5,6-trichloro-2-hydroxyphenyl)methane;   hexachlorophenum;   hexaclorofeno
 xref: CAS:70-30-4;   DrugBank:DB00756;   Drug_Central:1364;   HMDB:HMDB0014894;   KEGG:C08039;   KEGG:D00859;   LINCS:LSM-6032
 xref_mesh: MESH:D006582
 xref: PDBeChem:H3P;   PMID:1133685;   PMID:22313968;   PMID:23251633;   PMID:397166;   PMID:894425;   PMID:952574;   PPDB:381;   Patent:US2250480;   Patent:US2435593;   Patent:US2812365;   Reaxys:2064407;   Wikipedia:Hexachlorophene


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hexachlorophene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Hexachlorophene results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP Hexachlorophene results in decreased expression of BCL2 mRNA CTD PMID:25497112 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Hexachlorophene results in decreased expression of CCND1 mRNA; Hexachlorophene results in decreased expression of CCND1 protein CTD PMID:16735606 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit decreases expression ISO Hexachlorophene results in decreased expression of CHRNA4 mRNA CTD PMID:25943520 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit decreases expression EXP
ISO		 Hexachlorophene results in decreased expression of CHRNB2 mRNA CTD PMID:25497112 PMID:25943520 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases degradation		 ISO Hexachlorophene inhibits the reaction [Lithium Chloride results in increased expression of CTNNB1 protein]; Hexachlorophene inhibits the reaction [WNT3A protein results in increased expression of CTNNB1 protein]; SIAH1 protein promotes the reaction [Hexachlorophene results in increased degradation of CTNNB1 protein] CTD PMID:16735606 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Hexachlorophene results in increased expression of DDIT3 mRNA CTD PMID:32870474 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression ISO Hexachlorophene results in decreased expression of DLG4 mRNA CTD PMID:29301063 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dlx4 distal-less homeobox 4 increases methylation ISO Hexachlorophene results in increased methylation of DLX4 promoter CTD PMID:29301063 NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456 		JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 increases methylation ISO Hexachlorophene results in increased methylation of DMRT1 promoter CTD PMID:29301063 NCBI chr 1:223,142,859...223,241,333
Ensembl chr 1:223,142,859...223,241,333 		JBrowse link
G Eomes eomesodermin decreases expression ISO Hexachlorophene results in decreased expression of EOMES protein CTD PMID:25943520 NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions		 ISO Hexachlorophene binds to ESR1 protein
Hexachlorophene inhibits the reaction [Estradiol binds to ESR1 protein]		 CTD PMID:15081572 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression ISO Hexachlorophene results in decreased expression of GABBR1 mRNA CTD PMID:29301063 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 affects expression ISO Hexachlorophene affects the expression of GABBR2 mRNA CTD PMID:29301063 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 affects expression ISO Hexachlorophene affects the expression of GABRA1 mRNA CTD PMID:29301063 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 increases expression ISO Hexachlorophene results in increased expression of GABRB2 mRNA CTD PMID:29301063 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D decreases expression ISO Hexachlorophene results in decreased expression of GRIN2D mRNA CTD PMID:25943520 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression ISO Hexachlorophene results in decreased expression of GRM1 mRNA CTD PMID:25943520 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Hexachlorophene inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Homer1 homer scaffold protein 1 decreases expression ISO Hexachlorophene results in decreased expression of HOMER1 mRNA CTD PMID:29301063 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity ISO Hexachlorophene results in decreased activity of HSD3B1 protein CTD PMID:36965607 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity EXP Hexachlorophene results in decreased activity of HSD3B2 protein CTD PMID:36965607 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Hexachlorophene inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA] CTD PMID:32949729 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Hexachlorophene results in decreased expression of MYC protein CTD PMID:16735606 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nanog Nanog homeobox multiple interactions ISO Hexachlorophene inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of NANOG mRNA] CTD PMID:32949729 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions ISO Hexachlorophene inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of OTX2 mRNA] CTD PMID:32949729 NCBI chr15:21,942,233...21,953,034
Ensembl chr15:21,943,191...21,953,416 		JBrowse link
G Pax6 paired box 6 decreases expression
multiple interactions		 ISO Hexachlorophene results in decreased expression of PAX6 mRNA; Hexachlorophene results in decreased expression of PAX6 protein
Hexachlorophene inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA]		 CTD PMID:25943520 PMID:32949729 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 affects expression ISO Hexachlorophene affects the expression of PDK4 mRNA CTD PMID:32870474 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Plcb4 phospholipase C, beta 4 increases methylation ISO Hexachlorophene results in increased methylation of PLCB4 promoter CTD PMID:29301063 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO Hexachlorophene inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in decreased expression of POU5F1 mRNA] CTD PMID:32949729 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 increases expression
multiple interactions		 ISO Hexachlorophene results in increased expression of SIAH1 mRNA
SIAH1 protein promotes the reaction [Hexachlorophene results in increased degradation of CTNNB1 protein]		 CTD PMID:16735606 NCBI chr19:20,378,908...20,402,512
Ensembl chr19:20,378,439...20,403,808 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Hexachlorophene results in decreased expression of SOX2 mRNA; Hexachlorophene results in decreased expression of SOX2 protein CTD PMID:25943520 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Stx4 syntaxin 4 decreases expression ISO Hexachlorophene results in decreased expression of STX4A mRNA CTD PMID:29301063 NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979 		JBrowse link
G Tardbp TAR DNA binding protein decreases expression ISO Hexachlorophene results in decreased expression of TARDBP protein CTD PMID:25987361 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Hexachlorophene affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions ISO Hexachlorophene inhibits the reaction [WNT3A protein results in increased expression of CTNNB1 protein] CTD PMID:16735606 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
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  CHEBI ontology 19874
    role 19844
      application 19689
        pesticide 18062
          acaricide 13701
            hexachlorophene 36
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  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                carbocyclic compound 18579
                                  benzenoid aromatic compound 18003
                                    benzenes 17868
                                      chlorobenzenes 15043
                                        trichlorobenzene 2911
                                          hexachlorophene 36
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