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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Hexachloro-1,3-butadiene
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Accession:CHEBI:5691 term browser browse the term
Definition:An organochlorine compound that has formula C4Cl6.
Synonyms:related_synonym: Formula=C4Cl6;   HCBD;   Hexachlorobutadiene;   InChI=1S/C4Cl6/c5-1(3(7)8)2(6)4(9)10;   InChIKey=RWNKSTSCBHKHTB-UHFFFAOYSA-N;   SMILES=ClC(Cl)=C(Cl)C(Cl)=C(Cl)Cl
 xref: CAS:87-68-3;   KEGG:C11091
 xref_mesh: MESH:C001335


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Hexachloro-1,3-butadiene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP hexachlorobutadiene results in increased expression of ABCC3 mRNA CTD PMID:21905055 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Alb albumin increases expression EXP hexachlorobutadiene results in increased expression of ALB protein CTD PMID:21259293 PMID:21905055 PMID:23136149 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Anxa7 annexin A7 increases expression
affects expression		 EXP hexachlorobutadiene results in increased expression of ANXA7 mRNA
hexachlorobutadiene affects the expression of ANXA7 mRNA		 CTD PMID:21905055 PMID:23136149 NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385 		JBrowse link
G B2m beta-2 microglobulin increases expression EXP hexachlorobutadiene results in increased expression of B2M protein CTD PMID:2202081 PMID:21259293 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP hexachlorobutadiene results in increased expression of CCL2 mRNA CTD PMID:21905055 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Clu clusterin increases expression EXP hexachlorobutadiene results in increased expression of CLU protein CTD PMID:21259293 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Col1a1 collagen type I alpha 1 chain affects expression
decreases expression		 EXP hexachlorobutadiene affects the expression of COL1A1 mRNA
hexachlorobutadiene results in decreased expression of COL1A1 mRNA		 CTD PMID:21905055 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cryab crystallin, alpha B affects expression
increases expression		 EXP hexachlorobutadiene affects the expression of CRYAB mRNA
hexachlorobutadiene results in increased expression of CRYAB mRNA		 CTD PMID:21905055 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Cst3 cystatin C increases expression EXP hexachlorobutadiene results in increased expression of CST3 protein CTD PMID:21259293 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression		 EXP
ISO		 hexachlorobutadiene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
hexachlorobutadiene results in decreased expression of CYP1A1 mRNA		 CTD PMID:18493746 PMID:21905055 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of hexachlorobutadiene CTD PMID:8555406 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of hexachlorobutadiene CTD PMID:8555406 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions
decreases activity		 EXP hexachlorobutadiene affects the reaction [S-pentachlorobuta-1,3-dien-yl-cysteine results in decreased activity of DLD protein]
hexachlorobutadiene results in decreased activity of DLD protein		 CTD PMID:2360207 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression EXP hexachlorobutadiene results in increased expression of EPHX1 mRNA CTD PMID:21905055 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases expression
increases expression		 EXP hexachlorobutadiene results in decreased expression of G6PDX mRNA
hexachlorobutadiene results in increased expression of G6PDX mRNA		 CTD PMID:21905055 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
increases expression		 EXP hexachlorobutadiene results in decreased expression of GCLC mRNA
hexachlorobutadiene results in increased expression of GCLC mRNA		 CTD PMID:21905055 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Glul glutamate-ammonia ligase increases expression EXP hexachlorobutadiene results in increased expression of GLUL protein CTD PMID:10463391 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gpnmb glycoprotein nmb decreases expression
increases expression		 EXP hexachlorobutadiene results in decreased expression of GPNMB mRNA
hexachlorobutadiene results in increased expression of GPNMB mRNA		 CTD PMID:21905055 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
increases expression		 EXP hexachlorobutadiene results in decreased activity of GSR protein
hexachlorobutadiene results in increased expression of GSR mRNA		 CTD PMID:2360207 PMID:21905055 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gss glutathione synthetase decreases activity EXP hexachlorobutadiene results in decreased activity of GSS protein CTD PMID:15669050 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP hexachlorobutadiene results in increased expression of GSTA3 mRNA CTD PMID:21905055 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP hexachlorobutadiene results in increased expression of GSTM1 protein CTD PMID:21259293 PMID:21905055 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression EXP hexachlorobutadiene results in increased expression of GSTM4 mRNA CTD PMID:21905055 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP hexachlorobutadiene results in increased expression of HAVCR1 mRNA; hexachlorobutadiene results in increased expression of HAVCR1 protein CTD PMID:20305092 PMID:21259293 PMID:21905055 PMID:23136149 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP hexachlorobutadiene results in increased expression of HMOX1 mRNA CTD PMID:21905055 PMID:23136149 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta increases expression EXP hexachlorobutadiene results in increased expression of IL1B mRNA CTD PMID:21905055 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kng1 kininogen 1 decreases expression
increases expression		 EXP hexachlorobutadiene results in decreased expression of KNG1 mRNA
hexachlorobutadiene results in increased expression of KNG1 mRNA		 CTD PMID:21905055 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases expression
decreases activity		 EXP hexachlorobutadiene results in increased expression of KYAT1 protein
hexachlorobutadiene results in decreased activity of KYAT1 protein		 CTD PMID:9049049 PMID:9765069 PMID:15012908 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355 		JBrowse link
G Lcn2 lipocalin 2 decreases expression
increases expression
affects expression		 EXP hexachlorobutadiene results in decreased expression of LCN2 mRNA
hexachlorobutadiene results in increased expression of LCN2 protein
hexachlorobutadiene affects the expression of LCN2 mRNA		 CTD PMID:21259293 PMID:21905055 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP hexachlorobutadiene results in increased expression of MMP2 mRNA CTD PMID:21905055 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP hexachlorobutadiene results in increased expression of NQO1 mRNA CTD PMID:21905055 PMID:23136149 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Rgn regucalcin decreases expression EXP hexachlorobutadiene results in decreased expression of RGN mRNA CTD PMID:18805471 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP hexachlorobutadiene results in increased expression of SPP1 protein CTD PMID:21259293 PMID:23136149 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP hexachlorobutadiene results in increased expression of STAT3 mRNA CTD PMID:21905055 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
increases expression		 EXP hexachlorobutadiene results in decreased expression of TIMP1 mRNA
hexachlorobutadiene results in increased expression of TIMP1 mRNA; hexachlorobutadiene results in increased expression of TIMP1 protein		 CTD PMID:21259293 PMID:21905055 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP hexachlorobutadiene results in increased expression of TXNRD1 mRNA CTD PMID:21905055 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP hexachlorobutadiene results in increased expression of UGT1A6 mRNA CTD PMID:21905055 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
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  CHEBI ontology 19874
    chemical entity 19872
      molecular entity 19872
        main group molecular entity 19811
          p-block molecular entity 19811
            halogen molecular entity 18673
              chlorine molecular entity 18457
                organochlorine compound 18295
                  Hexachloro-1,3-butadiene 37
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  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      p-block molecular entity 19811
                        carbon group molecular entity 19751
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organohalogen compound 18523
                                organochlorine compound 18295
                                  Hexachloro-1,3-butadiene 37
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