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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:radicicol
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Accession:CHEBI:556075 term browser browse the term
Definition:An antifungal macrolactone antibiotic, obtained from Diheterospora chlamydosporia and Chaetomium chiversii that inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90).
Synonyms:related_synonym: (1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione;   Monorden
 alt_id: CHEBI:47650;   CHEBI:47652;   CHEBI:68728
 xref: CAS:12772-57-5;   DrugBank:DB03758
 xref_mesh: MESH:C035359
 xref: Reaxys:15865423;   pdb-ccd:RDC;   pubmed:16232632;   pubmed:16920739;   pubmed:18667483;   pubmed:20093793;   pubmed:20961859;   pubmed:21800052;   wikipedia.en:Radicicol
 chemrof_formula: C18H17ClO6
 chemrof_smiles: C[C@@H]1C[C@H]2O[C@@H]2/C=CC=CC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1
 chemrof_inchi: InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
 chemrof_inchikey: WYZWZEOGROVVHK-GTMNPGAYSA-N


show annotations for term's descendants           Sort by:
radicicol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases expression
multiple interactions 		ISO monorden results in decreased expression of AHR protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [monorden results in decreased expression of AHR protein] 		CTD PMID:20057149 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO monorden inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] CTD PMID:12530016 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Eln elastin increases expression ISO monorden results in increased expression of ELN protein CTD PMID:21880723 NCBI chr12:27,604,983...27,648,413
Ensembl chr12:27,604,680...27,648,413 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO monorden analog results in decreased expression of ESR1 protein; monorden results in decreased expression of ESR1 protein CTD PMID:11448926 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP monorden inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of GJA1 protein] CTD PMID:29155206 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [monorden co-treated with cobaltous chloride] results in increased expression of HIF1A protein CTD PMID:29155206 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO monorden analog results in increased expression of HSPA1A protein; monorden results in increased expression of HSPA1A protein CTD PMID:11448926 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP monorden inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
decreases expression 		ISO monorden results in decreased activity of KCNH2 protein
monorden results in decreased expression of KCNH2 protein modified form 		CTD PMID:12775586 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP monorden inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:15583003 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G P2rx1 purinergic receptor P2X 1 multiple interactions EXP monorden promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX1] CTD PMID:11930156 NCBI chr10:58,117,107...58,132,167
Ensembl chr10:58,117,088...58,132,164 		JBrowse link
G Pgr progesterone receptor decreases expression ISO monorden analog results in decreased expression of PGR protein alternative form CTD PMID:11448926 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation ISO monorden affects the phosphorylation of RB1 protein CTD PMID:21880723 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rngtt RNA guanylyltransferase and 5'-phosphatase decreases expression ISO monorden results in decreased expression of RNGTT protein CTD PMID:30166341 NCBI chr 5:52,503,335...52,709,604
Ensembl chr 5:52,503,313...52,709,597 		JBrowse link
G Vldlr very low density lipoprotein receptor multiple interactions EXP monorden inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein] CTD PMID:15808840 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        antimicrobial agent 18216
          macrolide antibiotic 760
            radicicol 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  ester 17841
                                    carboxylic ester 17347
                                      lactone 13231
                                        macrocyclic lactone 7632
                                          macrolide 4488
                                            macrolide antibiotic 760
                                              radicicol 15
paths to the root