CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: ifosfamides
Accession: CHEBI:55369
browse the term
Definition: Compounds containing an ifosfamide skeleton.
Synonyms: related_synonym: isosfamides
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases expression multiple interactions
ISO
Ifosfamide results in increased expression of ABCB1 protein [Ifosfamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; NR1I2 protein promotes the reaction [Ifosfamide results in increased expression of ABCB1 protein]
CTD
PMID:20041327
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcb6
ATP binding cassette subfamily B member 6
increases expression
ISO
Ifosfamide results in increased expression of ABCB6 mRNA
CTD
PMID:25596134
NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
G
Abcb9
ATP binding cassette subfamily B member 9
increases expression
ISO
Ifosfamide results in increased expression of ABCB9 mRNA
CTD
PMID:25596134
NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931
G
Abcg1
ATP binding cassette subfamily G member 1
decreases expression
ISO
Ifosfamide results in decreased expression of ABCG1 mRNA
CTD
PMID:25596134
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
G
Abhd4
abhydrolase domain containing 4, N-acyl phospholipase B
increases expression
ISO
Ifosfamide results in increased expression of ABHD4 mRNA
CTD
PMID:25596134
NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
G
Ache
acetylcholinesterase
increases activity multiple interactions
EXP
Ifosfamide results in increased activity of ACHE protein morin inhibits the reaction [Ifosfamide results in increased activity of ACHE protein]
CTD
PMID:31722249
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Acsl1
acyl-CoA synthetase long-chain family member 1
decreases expression
ISO
Ifosfamide results in decreased expression of ACSL1 mRNA
CTD
PMID:25596134
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
G
Agrn
agrin
increases expression
ISO
Ifosfamide results in increased expression of AGRN mRNA
CTD
PMID:25596134
NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
G
Ahr
aryl hydrocarbon receptor
affects activity
ISO
Ifosfamide affects the activity of AHR protein
CTD
PMID:25596134
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Ak4
adenylate kinase 4
increases expression
ISO
Ifosfamide results in increased expression of AK4 mRNA
CTD
PMID:25596134
NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
G
Akr1c2
aldo-keto reductase family 1, member C2
increases expression
ISO
Ifosfamide results in increased expression of AKR1C2 mRNA
CTD
PMID:25596134
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
G
Aldh1a3
aldehyde dehydrogenase 1 family, member A3
increases expression
ISO
Ifosfamide results in increased expression of ALDH1A3 mRNA
CTD
PMID:25596134
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
G
Aldoa
aldolase, fructose-bisphosphate A
increases expression
ISO
Ifosfamide results in increased expression of ALDOA mRNA
CTD
PMID:25596134
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
G
Als2cl
ALS2 C-terminal like
affects expression
ISO
Ifosfamide affects the expression of ALS2CL mRNA
CTD
PMID:25596134
NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419
G
Ankra2
ankyrin repeat family A member 2
decreases expression
ISO
Ifosfamide results in decreased expression of ANKRA2 mRNA
CTD
PMID:25596134
NCBI chr 2:29,612,867...29,623,748
Ensembl chr 2:29,612,925...29,623,730
G
Arhgef10
Rho guanine nucleotide exchange factor 10
affects expression
ISO
Ifosfamide affects the expression of ARHGEF10 mRNA
CTD
PMID:25596134
NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173
G
Arln
allregulin
decreases expression
ISO
Ifosfamide results in decreased expression of ARLN mRNA
CTD
PMID:25596134
NCBI chr 2:211,055,925...211,057,685
Ensembl chr 2:211,055,911...211,057,681
G
Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Ifosfamide results in increased expression of ASNS mRNA
CTD
PMID:25596134
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
G
Atf4
activating transcription factor 4
affects activity
ISO
Ifosfamide affects the activity of ATF4 protein
CTD
PMID:25596134
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
G
Atosa
atos homolog A
decreases expression
ISO
Ifosfamide results in decreased expression of ATOSA mRNA
CTD
PMID:25596134
NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549
G
Atxn1
ataxin 1
decreases expression
ISO
Ifosfamide results in decreased expression of ATXN1 mRNA
CTD
PMID:25596134
NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360
G
Aurkb
aurora kinase B
increases expression
ISO
Ifosfamide results in increased expression of AURKB mRNA
CTD
PMID:25596134
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
G
Avp
arginine vasopressin
multiple interactions
ISO
[Ifosfamide co-treated with Mesna] results in increased expression of AVP protein
CTD
PMID:2261371
NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
G
Axl
Axl receptor tyrosine kinase
increases expression
ISO
Ifosfamide results in increased expression of AXL mRNA
CTD
PMID:25596134
NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265
G
B2m
beta-2 microglobulin
increases expression
ISO
Ifosfamide results in increased expression of B2M protein
CTD
PMID:8625085 PMID:9261752
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Ifosfamide results in increased expression of BAX mRNA
CTD
PMID:25596134
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcat1
branched chain amino acid transaminase 1
decreases expression
ISO
Ifosfamide results in decreased expression of BCAT1 mRNA
CTD
PMID:25596134
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
G
Bche
butyrylcholinesterase
increases activity multiple interactions
EXP
Ifosfamide results in increased activity of BCHE protein morin inhibits the reaction [Ifosfamide results in increased activity of BCHE protein]
CTD
PMID:31722249
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
G
Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO EXP
BCL2 protein inhibits the reaction [Ifosfamide results in increased activity of CASP9 protein] Ifosfamide results in decreased expression of BCL2 mRNA Carnitine inhibits the reaction [Ifosfamide results in decreased expression of BCL2 mRNA]; morin inhibits the reaction [Ifosfamide results in decreased expression of BCL2 mRNA]
CTD
PMID:11723234 PMID:23213347 PMID:31722249
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bdnf
brain-derived neurotrophic factor
multiple interactions increases expression
EXP
morin inhibits the reaction [Ifosfamide results in increased expression of BDNF mRNA]
CTD
PMID:31722249
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Bglap
bone gamma-carboxyglutamate protein
decreases expression
ISO
Ifosfamide results in decreased expression of BGLAP protein
CTD
PMID:1525342
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
G
Bhlhe40
basic helix-loop-helix family, member e40
increases expression
ISO
Ifosfamide results in increased expression of BHLHE40 mRNA
CTD
PMID:25596134
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
G
Bnip3
BCL2 interacting protein 3
decreases expression
ISO
Ifosfamide results in decreased expression of BNIP3 mRNA
CTD
PMID:25596134
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
G
Brd2
bromodomain containing 2
decreases expression
ISO
Ifosfamide results in decreased expression of BRD2 mRNA
CTD
PMID:25596134
NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
G
Btg2
BTG anti-proliferation factor 2
increases expression
ISO
Ifosfamide results in increased expression of BTG2 mRNA
CTD
PMID:25596134
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
G
C15h8orf58
similar to human chromosome 8 open reading frame 58
increases expression
ISO
Ifosfamide results in increased expression of C8ORF58 mRNA
CTD
PMID:25596134
NCBI chr15:45,228,615...45,235,274
Ensembl chr15:45,228,615...45,233,254
G
Camkk2
calcium/calmodulin-dependent protein kinase kinase 2
increases expression
ISO
Ifosfamide results in increased expression of CAMKK2 mRNA
CTD
PMID:25596134
NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
G
Cars1
cysteinyl-tRNA synthetase 1
decreases expression
ISO
Ifosfamide results in decreased expression of CARS1 mRNA
CTD
PMID:25596134
NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
G
Casp1
caspase 1
increases response to substance
ISO
CASP1 results in increased susceptibility to Ifosfamide
CTD
PMID:9491796
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Casp3
caspase 3
multiple interactions increases expression increases activity
EXP
Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP3 mRNA]; morin inhibits the reaction [Ifosfamide results in increased activity of CASP3 protein]
CTD
PMID:23213347 PMID:31722249
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
multiple interactions increases expression
ISO EXP
BCL2 protein inhibits the reaction [Ifosfamide results in increased activity of CASP9 protein] Ifosfamide results in increased expression of CASP9 mRNA Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP9 mRNA]
CTD
PMID:11723234 PMID:23213347
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cat
catalase
multiple interactions decreases expression decreases activity
EXP
Carnitine inhibits the reaction [Ifosfamide results in decreased expression of CAT mRNA]; morin inhibits the reaction [Ifosfamide results in decreased activity of CAT protein]
CTD
PMID:23213347 PMID:31722249
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ccdc90b
coiled-coil domain containing 90B
decreases expression
ISO
Ifosfamide results in decreased expression of CCDC90B mRNA
CTD
PMID:25596134
NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338
G
Ccne2
cyclin E2
increases expression
ISO
Ifosfamide results in increased expression of CCNE2 mRNA
CTD
PMID:25596134
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
G
Ccng2
cyclin G2
decreases expression
ISO
Ifosfamide results in decreased expression of CCNG2 mRNA
CTD
PMID:25596134
NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
G
Cda
cytidine deaminase
multiple interactions
EXP
[CYP2B1 co-treated with CDA] results in increased susceptibility to [Ifosfamide co-treated with Fluorouracil]; [CYP2B1 co-treated with CDA] results in increased susceptibility to Ifosfamide
CTD
PMID:10811482
NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231
G
Cdk6
cyclin-dependent kinase 6
affects expression
ISO
Ifosfamide affects the expression of CDK6 mRNA
CTD
PMID:25596134
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Ifosfamide results in increased expression of CDKN1A mRNA
CTD
PMID:25596134
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cers5
ceramide synthase 5
increases expression
ISO
Ifosfamide results in increased expression of CERS5 mRNA
CTD
PMID:25596134
NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947
G
Cmbl
carboxymethylenebutenolidase homolog
increases expression
ISO
Ifosfamide results in increased expression of CMBL mRNA
CTD
PMID:25596134
NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
G
Ctdp1
CTD phosphatase subunit 1
decreases expression
ISO
Ifosfamide results in decreased expression of CTDP1 mRNA
CTD
PMID:25596134
NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457
G
Cth
cystathionine gamma-lyase
affects expression
ISO
Ifosfamide affects the expression of CTH mRNA
CTD
PMID:25596134
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
G
Ctsc
cathepsin C
increases expression
ISO
Ifosfamide results in increased expression of CTSC mRNA
CTD
PMID:25596134
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
G
Cttn
cortactin
increases expression
ISO
Ifosfamide results in increased expression of CTTN mRNA
CTD
PMID:25596134
NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases response to substance decreases expression
ISO
CYP1A1 protein results in increased susceptibility to Ifosfamide Ifosfamide results in decreased expression of CYP1A1 mRNA
CTD
PMID:20507880 PMID:25596134
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO
Ifosfamide results in increased expression of CYP1A2 mRNA
CTD
PMID:25596134
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases expression
ISO
Ifosfamide results in decreased expression of CYP1B1 mRNA
CTD
PMID:25596134
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
multiple interactions increases hydroxylation increases metabolic processing increases activity increases response to substance
EXP
[CYP2B1 co-treated with CDA] results in increased susceptibility to [Ifosfamide co-treated with Fluorouracil]; [CYP2B1 co-treated with CDA] results in increased susceptibility to Ifosfamide; Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Ifosfamide]; Mitomycin affects the reaction [CYP2B1 results in increased susceptibility to Ifosfamide] CYP2B1 protein mutant form results in increased hydroxylation of Ifosfamide CYP2B1 protein results in increased metabolism of Ifosfamide; CYP2B1 results in increased metabolism of Ifosfamide CYP2B1 results in increased activity of Ifosfamide
CTD
PMID:2272335 PMID:7834628 PMID:8640822 PMID:9592392 PMID:10415877 PMID:10811482 PMID:15102956 More...
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases response to substance multiple interactions affects metabolic processing
ISO
CYP2B6 results in increased susceptibility to Ifosfamide POR promotes the reaction [CYP2B6 results in increased susceptibility to Ifosfamide] CYP2B6 protein affects the metabolism of Ifosfamide
CTD
PMID:9766669 PMID:15875221
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases activity increases response to substance multiple interactions increases metabolic processing
ISO
CYP2C18 results in increased activity of Ifosfamide CYP2C18 results in increased susceptibility to Ifosfamide POR promotes the reaction [CYP2C18 results in increased susceptibility to Ifosfamide] CYP2C18 results in increased metabolism of Ifosfamide
CTD
PMID:9241661 PMID:9766669 PMID:15301741
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases response to substance increases activity
ISO
CYP2C19 protein results in increased susceptibility to Ifosfamide CYP2C19 results in increased activity of Ifosfamide
CTD
PMID:9241661 PMID:20507880
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
increases activity
ISO
CYP2C8 results in increased activity of Ifosfamide
CTD
PMID:9241661
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
increases response to substance
ISO
CYP2D6 protein results in increased susceptibility to Ifosfamide
CTD
PMID:20507880
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression decreases ethylation affects degradation increases response to substance affects metabolic processing affects hydroxylation
ISO
Ifosfamide results in increased expression of CYP3A4 mRNA CYP3A4 gene mutant form results in decreased ethylation of Ifosfamide; CYP3A4 protein results in decreased ethylation of Ifosfamide CYP3A4 protein affects the degradation of Ifosfamide CYP3A4 protein results in increased susceptibility to Ifosfamide; CYP3A4 results in increased susceptibility to Ifosfamide CYP3A4 protein affects the metabolism of Ifosfamide CYP3A4 protein affects the hydroxylation of Ifosfamide
CTD
PMID:9766669 PMID:12136253 PMID:15821045 PMID:15875221 PMID:18839173 PMID:20507880 More...
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases hydroxylation
EXP
CYP3A23-3A1 protein results in increased hydroxylation of Ifosfamide
CTD
PMID:15919850
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
affects metabolic processing decreases ethylation
ISO
CYP3A5 protein affects the metabolism of Ifosfamide CYP3A5 protein results in decreased ethylation of Ifosfamide
CTD
PMID:15821045 PMID:15875221
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Ifosfamide results in increased expression of DDIT3 mRNA
CTD
PMID:25596134
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Ddit4
DNA-damage-inducible transcript 4
increases expression
ISO
Ifosfamide results in increased expression of DDIT4 mRNA
CTD
PMID:25596134
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
G
Ddx17
DEAD-box helicase 17
decreases expression
ISO
Ifosfamide results in decreased expression of DDX17 mRNA
CTD
PMID:25596134
NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
G
Dgka
diacylglycerol kinase, alpha
increases expression
ISO
Ifosfamide results in increased expression of DGKA mRNA
CTD
PMID:25596134
NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
G
Dlx1
distal-less homeobox 1
decreases expression
ISO
Ifosfamide results in decreased expression of DLX1 mRNA
CTD
PMID:25596134
NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780
G
Dnai3
dynein axonemal intermediate chain 3
decreases expression
ISO
Ifosfamide results in decreased expression of DNAI3 mRNA
CTD
PMID:25596134
NCBI chr 2:234,947,910...235,006,173
Ensembl chr 2:234,929,677...235,006,173
G
Dnajb2
DnaJ heat shock protein family (Hsp40) member B2
increases expression
ISO
Ifosfamide results in increased expression of DNAJB2 mRNA
CTD
PMID:25596134
NCBI chr 9:76,731,060...76,739,278
Ensembl chr 9:76,731,065...76,739,277
G
Dnajb9
DnaJ heat shock protein family (Hsp40) member B9
increases expression
ISO
Ifosfamide results in increased expression of DNAJB9 mRNA
CTD
PMID:25596134
NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
G
Dnmbp
dynamin binding protein
increases expression
ISO
Ifosfamide results in increased expression of DNMBP mRNA
CTD
PMID:25596134
NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604
G
Dpm3
dolichyl-phosphate mannosyltransferase subunit 3, regulatory
increases expression
ISO
Ifosfamide results in increased expression of DPM3 mRNA
CTD
PMID:25596134
NCBI chr 2:174,676,532...174,677,047
Ensembl chr 2:174,676,363...174,677,668 Ensembl chr15:174,676,363...174,677,668
G
Dusp22
dual specificity phosphatase 22
increases expression
ISO
Ifosfamide results in increased expression of DUSP22 mRNA
CTD
PMID:25596134
NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321
G
Efna1
ephrin A1
decreases expression
ISO
Ifosfamide results in decreased expression of EFNA1 mRNA
CTD
PMID:25596134
NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
G
Eif1
eukaryotic translation initiation factor 1
increases expression
ISO
Ifosfamide results in increased expression of EIF1 mRNA
CTD
PMID:25596134
NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327 Ensembl chr 5:85,246,764...85,427,327
G
Eif3c
eukaryotic translation initiation factor 3, subunit C
decreases expression
ISO
Ifosfamide results in decreased expression of EIF3C mRNA
CTD
PMID:25596134
NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
G
Elf4
E74 like ETS transcription factor 4
increases expression
ISO
Ifosfamide results in increased expression of ELF4 mRNA
CTD
PMID:25596134
NCBI chr X:127,587,401...127,639,063
Ensembl chr X:127,590,650...127,630,200
G
Elk4
ETS transcription factor ELK4
decreases expression
ISO
Ifosfamide results in decreased expression of ELK4 mRNA
CTD
PMID:25596134
NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035
G
Eno2
enolase 2
increases expression
ISO
Ifosfamide results in increased expression of ENO2 mRNA
CTD
PMID:25596134
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
G
Enosf1
enolase superfamily member 1
decreases expression
ISO
Ifosfamide results in decreased expression of ENOSF1 mRNA
CTD
PMID:25596134
NCBI chr 9:113,275,267...113,314,842
G
Ep400
E1A binding protein p400
decreases expression
ISO
Ifosfamide results in decreased expression of EP400 mRNA
CTD
PMID:25596134
NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861
G
Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
increases expression
ISO
Ifosfamide results in increased expression of ERO1A mRNA
CTD
PMID:25596134
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
G
Exoc7
exocyst complex component 7
increases expression
ISO
Ifosfamide results in increased expression of EXOC7 mRNA
CTD
PMID:25596134
NCBI chr10:101,521,630...101,540,425
Ensembl chr10:101,520,927...101,540,561
G
Fabp3
fatty acid binding protein 3
decreases expression
ISO
Ifosfamide results in decreased expression of FABP3 mRNA
CTD
PMID:25596134
NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
G
Fam162a
family with sequence similarity 162, member A
decreases expression
ISO
Ifosfamide results in decreased expression of FAM162A mRNA
CTD
PMID:25596134
NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239
G
Fam210b
family with sequence similarity 210, member B
decreases expression
ISO
Ifosfamide results in decreased expression of FAM210B mRNA
CTD
PMID:25596134
NCBI chr 3:161,118,228...161,128,400
Ensembl chr 3:161,118,239...161,128,397
G
Fam89a
family with sequence similarity 89, member A
increases expression
ISO
Ifosfamide results in increased expression of FAM89A mRNA
CTD
PMID:25596134
NCBI chr19:52,710,002...52,722,630
Ensembl chr19:52,710,019...52,722,631
G
Faslg
Fas ligand
increases expression
ISO
Ifosfamide results in increased expression of FASL
CTD
PMID:16453328
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
G
Fbxo22
F-box protein 22
increases expression
ISO
Ifosfamide results in increased expression of FBXO22 mRNA
CTD
PMID:25596134
NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
G
Fbxo30
F-box protein 30
decreases expression
ISO
Ifosfamide results in decreased expression of FBXO30 mRNA
CTD
PMID:25596134
NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
G
Fech
ferrochelatase
decreases expression
ISO
Ifosfamide results in decreased expression of FECH mRNA
CTD
PMID:25596134
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
G
Flvcr2
FLVCR choline and putative heme transporter 2
decreases expression
ISO
Ifosfamide results in decreased expression of FLVCR2 mRNA
CTD
PMID:25596134
NCBI chr 6:105,408,355...105,472,355
Ensembl chr 6:105,408,339...105,472,353
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
EXP
morin inhibits the reaction [Ifosfamide results in increased expression of FOS protein]
CTD
PMID:31722249
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
ISO
Ifosfamide results in increased expression of FOSL1 mRNA
CTD
PMID:25596134
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
G
Gars1
glycyl-tRNA synthetase 1
increases expression
ISO
Ifosfamide results in increased expression of GARS1 mRNA
CTD
PMID:25596134
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
G
Gclc
glutamate-cysteine ligase, catalytic subunit
decreases expression
ISO
Ifosfamide results in decreased expression of GCLC mRNA
CTD
PMID:25596134
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Ifosfamide results in increased expression of GCLM mRNA
CTD
PMID:25596134
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gdf15
growth differentiation factor 15
increases expression
ISO
Ifosfamide results in increased expression of GDF15 mRNA
CTD
PMID:25596134
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
G
Gfap
glial fibrillary acidic protein
increases expression multiple interactions
EXP
Ifosfamide results in increased expression of GFAP protein morin inhibits the reaction [Ifosfamide results in increased expression of GFAP protein]
CTD
PMID:31722249
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Gpat3
glycerol-3-phosphate acyltransferase 3
increases expression
ISO
Ifosfamide results in increased expression of GPAT3 mRNA
CTD
PMID:25596134
NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
G
Gpr87
G protein-coupled receptor 87
decreases expression
ISO
Ifosfamide results in decreased expression of GPR87 mRNA
CTD
PMID:25596134
NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190
G
Gpr88
G-protein coupled receptor 88
increases expression
ISO
Ifosfamide results in increased expression of GPR88 mRNA
CTD
PMID:25596134
NCBI chr 2:204,191,443...204,199,576
Ensembl chr 2:204,191,427...204,199,733
G
Gpx1
glutathione peroxidase 1
multiple interactions decreases expression
EXP
Carnitine inhibits the reaction [Ifosfamide results in decreased expression of GPX1 mRNA]
CTD
PMID:23213347
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Gpx3
glutathione peroxidase 3
decreases activity
ISO
Ifosfamide results in decreased activity of GPX3 protein
CTD
PMID:9851889
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
G
Gsr
glutathione-disulfide reductase
increases expression
ISO
Ifosfamide results in increased expression of GSR mRNA
CTD
PMID:25596134
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gstp1
glutathione S-transferase pi 1
affects response to substance increases response to substance
ISO
GSTP1 gene polymorphism affects the susceptibility to Ifosfamide GSTP1 gene polymorphism results in increased susceptibility to Ifosfamide
CTD
PMID:12868187 PMID:16282887
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Herc3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
decreases expression
ISO
Ifosfamide results in decreased expression of HERC3 mRNA
CTD
PMID:25596134
NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488
G
Hif1a
hypoxia inducible factor 1 subunit alpha
affects activity
ISO
Ifosfamide affects the activity of HIF1A protein
CTD
PMID:25596134
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Hspa1b
heat shock protein family A (Hsp70) member 1B
increases expression
ISO
Ifosfamide results in increased expression of HSPA1B mRNA
CTD
PMID:25596134
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
G
Iars1
isoleucyl-tRNA synthetase 1
increases expression
ISO
Ifosfamide results in increased expression of IARS1 mRNA
CTD
PMID:25596134
NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
G
Ids
iduronate 2-sulfatase
decreases expression
ISO
Ifosfamide results in decreased expression of IDS mRNA
CTD
PMID:25596134
NCBI chr X:149,025,976...149,046,641
Ensembl chr X:149,025,976...149,046,663
G
Ifnb1
interferon beta 1
multiple interactions
ISO
[Ifosfamide co-treated with IFNB1] affects the expression of MMP9 mRNA; [Ifosfamide co-treated with IFNB1] affects the expression of MMP9 protein; [Ifosfamide co-treated with IFNB1] results in decreased expression of PLAUR protein; IFNB1 promotes the reaction [Ifosfamide results in decreased activity of MMP9 protein]; IFNB1 promotes the reaction [Ifosfamide results in decreased expression of VEGFA protein]
CTD
PMID:15659795
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
G
Igf2r
insulin-like growth factor 2 receptor
increases expression
ISO
Ifosfamide results in increased expression of IGF2R mRNA
CTD
PMID:25596134
NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
G
Il19
interleukin 19
increases secretion
ISO
Ifosfamide results in increased secretion of IL19 protein
CTD
PMID:24714768
NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
G
Il1b
interleukin 1 beta
increases secretion multiple interactions
EXP
Ifosfamide results in increased secretion of IL1B protein resveratrol inhibits the reaction [Ifosfamide results in increased secretion of IL1B protein]
CTD
PMID:17481685
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
increases secretion multiple interactions
EXP
Ifosfamide results in increased secretion of IL6 protein resveratrol inhibits the reaction [Ifosfamide results in increased secretion of IL6 protein]
CTD
PMID:17481685
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Inka2
inka box actin regulator 2
increases expression
ISO
Ifosfamide results in increased expression of INKA2 mRNA
CTD
PMID:25596134
NCBI chr 2:193,185,275...193,200,643
Ensembl chr 2:193,185,275...193,200,642
G
Insig2
insulin induced gene 2
increases expression
ISO
Ifosfamide results in increased expression of INSIG2 mRNA
CTD
PMID:25596134
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
G
Itfg2
integrin alpha FG-GAP repeat containing 2
decreases expression
ISO
Ifosfamide results in decreased expression of ITFG2 mRNA
CTD
PMID:25596134
NCBI chr 4:161,684,249...161,698,315
Ensembl chr 4:161,684,249...161,698,422
G
Itgb1
integrin subunit beta 1
affects expression
ISO
Ifosfamide affects the expression of ITGB1 mRNA
CTD
PMID:25596134
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Kat6b
lysine acetyltransferase 6B
decreases expression
ISO
Ifosfamide results in decreased expression of KAT6B mRNA
CTD
PMID:25596134
NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316
G
Kdm3a
lysine demethylase 3A
decreases expression
ISO
Ifosfamide results in decreased expression of KDM3A mRNA
CTD
PMID:25596134
NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073
G
Keap1
Kelch-like ECH-associated protein 1
increases expression
ISO
Ifosfamide results in increased expression of KEAP1 mRNA
CTD
PMID:25596134
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
G
Krt15
keratin 15
increases expression
ISO
Ifosfamide results in increased expression of KRT15 mRNA
CTD
PMID:25596134
NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799
G
Krt19
keratin 19
increases expression
ISO
Ifosfamide results in increased expression of KRT19 mRNA
CTD
PMID:25596134
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
G
Lama3
laminin subunit alpha 3
increases expression
ISO
Ifosfamide results in increased expression of LAMA3 mRNA
CTD
PMID:25596134
NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
G
Lmcd1
LIM and cysteine-rich domains 1
decreases expression
ISO
Ifosfamide results in decreased expression of LMCD1 mRNA
CTD
PMID:25596134
NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
G
Ltn1
listerin E3 ubiquitin protein ligase 1
decreases expression
ISO
Ifosfamide results in decreased expression of LTN1 mRNA
CTD
PMID:25596134
NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886
G
Mafg
MAF bZIP transcription factor G
increases expression
ISO
Ifosfamide results in increased expression of MAFG mRNA
CTD
PMID:25596134
NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
G
Mapk8
mitogen-activated protein kinase 8
increases activity multiple interactions
EXP
Ifosfamide results in increased activity of MAPK8 protein morin inhibits the reaction [Ifosfamide results in increased activity of MAPK8 protein]
CTD
PMID:31722249
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mdm2
MDM2 proto-oncogene
increases expression
ISO
Ifosfamide results in increased expression of MDM2 mRNA
CTD
PMID:25596134
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
G
Me1
malic enzyme 1
decreases expression
ISO
Ifosfamide results in decreased expression of ME1 mRNA
CTD
PMID:25596134
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
G
Mmp9
matrix metallopeptidase 9
multiple interactions affects expression decreases activity
ISO
[Ifosfamide co-treated with IFNA2] affects the expression of MMP9 mRNA; [Ifosfamide co-treated with IFNA2] affects the expression of MMP9 protein; [Ifosfamide co-treated with IFNB1] affects the expression of MMP9 mRNA; [Ifosfamide co-treated with IFNB1] affects the expression of MMP9 protein; IFNA2 promotes the reaction [Ifosfamide results in decreased activity of MMP9 protein]; IFNB1 promotes the reaction [Ifosfamide results in decreased activity of MMP9 protein] Ifosfamide affects the expression of MMP9 mRNA
CTD
PMID:15659795
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mr1
major histocompatibility complex, class I-related
affects expression
ISO
Ifosfamide affects the expression of MR1 mRNA
CTD
PMID:25811541
NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
G
Mt2A
metallothionein 2A
increases expression
ISO
Ifosfamide results in increased expression of MT2A mRNA
CTD
PMID:25596134
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
G
Mtdh
metadherin
decreases expression
ISO
Ifosfamide results in decreased expression of MTDH mRNA
CTD
PMID:25596134
NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413
G
Mtfp1
mitochondrial fission process 1
increases expression
ISO
Ifosfamide results in increased expression of MTFP1 mRNA
CTD
PMID:25596134
NCBI chr14:78,968,434...78,972,274
Ensembl chr14:78,968,442...78,972,274
G
Mxi1
MAX interactor 1, dimerization protein
decreases expression
ISO
Ifosfamide results in decreased expression of MXI1 mRNA
CTD
PMID:25596134
NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
G
Ncapd2
non-SMC condensin I complex, subunit D2
increases expression
ISO
Ifosfamide results in increased expression of NCAPD2 mRNA
CTD
PMID:25596134
NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020
G
Nedd9
neural precursor cell expressed, developmentally down-regulated 9
decreases expression
ISO
Ifosfamide results in decreased expression of NEDD9 mRNA
CTD
PMID:25596134
NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
G
Nfe2l2
NFE2 like bZIP transcription factor 2
affects activity multiple interactions decreases expression
ISO EXP
Ifosfamide affects the activity of NFE2L2 protein morin inhibits the reaction [Ifosfamide results in decreased expression of NFE2L2 protein]
CTD
PMID:25596134 PMID:31722249
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nin
ninein
decreases expression
ISO
Ifosfamide results in decreased expression of NIN mRNA
CTD
PMID:25596134
NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
G
Nos1
nitric oxide synthase 1
increases activity multiple interactions
EXP
Ifosfamide results in increased activity of NOS1 protein morin inhibits the reaction [Ifosfamide results in increased activity of NOS1 protein]
CTD
PMID:31722249
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
G
Nos2
nitric oxide synthase 2
multiple interactions increases expression
EXP
Carnitine inhibits the reaction [Ifosfamide results in increased expression of NOS2 mRNA]
CTD
PMID:23213347
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Npy1r
neuropeptide Y receptor Y1
increases expression
ISO
Ifosfamide results in increased expression of NPY1R mRNA
CTD
PMID:25596134
NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
G
Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression
ISO
Ifosfamide results in decreased expression of NQO1 mRNA
CTD
PMID:25596134
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity
ISO
[Ifosfamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; Ifosfamide binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Ifosfamide results in increased expression of ABCB1 protein]
CTD
PMID:18839173 PMID:20041327
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nrep
neuronal regeneration related protein
affects expression
ISO
Ifosfamide affects the expression of NREP mRNA
CTD
PMID:25596134
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
G
Ntpcr
nucleoside-triphosphatase, cancer-related
increases expression
ISO
Ifosfamide results in increased expression of NTPCR mRNA
CTD
PMID:25596134
NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202
G
Nuak1
NUAK family kinase 1
decreases expression
ISO
Ifosfamide results in decreased expression of NUAK1 mRNA
CTD
PMID:25596134
NCBI chr 7:19,330,034...19,401,918
Ensembl chr 7:19,329,933...19,401,913
G
Osgin1
oxidative stress induced growth inhibitor 1
decreases expression
ISO
Ifosfamide results in decreased expression of OSGIN1 mRNA
CTD
PMID:25596134
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
G
P4ha1
prolyl 4-hydroxylase subunit alpha 1
decreases expression
ISO
Ifosfamide results in decreased expression of P4HA1 mRNA
CTD
PMID:25596134
NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
G
Pank1
pantothenate kinase 1
decreases expression
ISO
Ifosfamide results in decreased expression of PANK1 mRNA
CTD
PMID:25596134
NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829
G
Pde8a
phosphodiesterase 8A
decreases expression
ISO
Ifosfamide results in decreased expression of PDE8A mRNA
CTD
PMID:25596134
NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
G
Pdia5
protein disulfide isomerase family A, member 5
increases expression
ISO
Ifosfamide results in increased expression of PDIA5 mRNA
CTD
PMID:25596134
NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084
G
Pdk1
pyruvate dehydrogenase kinase 1
decreases expression
ISO
Ifosfamide results in decreased expression of PDK1 mRNA
CTD
PMID:25596134
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
G
Phgdh
phosphoglycerate dehydrogenase
increases expression
ISO
Ifosfamide results in increased expression of PHGDH mRNA
CTD
PMID:25596134
NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
G
Phlda3
pleckstrin homology-like domain, family A, member 3
increases expression
ISO
Ifosfamide results in increased expression of PHLDA3 mRNA
CTD
PMID:25596134
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
G
Pidd1
p53-induced death domain protein 1
decreases expression
ISO
Ifosfamide results in decreased expression of PIDD1 mRNA
CTD
PMID:25596134
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
G
Plaur
plasminogen activator, urokinase receptor
affects expression multiple interactions
ISO
Ifosfamide affects the expression of PLAUR protein [Ifosfamide co-treated with IFNA2] results in decreased expression of PLAUR protein; [Ifosfamide co-treated with IFNB1] results in decreased expression of PLAUR protein
CTD
PMID:15659795
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
G
Pmepa1
prostate transmembrane protein, androgen induced 1
increases expression
ISO
Ifosfamide results in increased expression of PMEPA1 mRNA
CTD
PMID:25596134
NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
G
Podxl
podocalyxin-like
decreases expression
ISO
Ifosfamide results in decreased expression of PODXL mRNA
CTD
PMID:25596134
NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899
G
Por
cytochrome p450 oxidoreductase
multiple interactions
ISO
POR promotes the reaction [CYP2B6 results in increased susceptibility to Ifosfamide]; POR promotes the reaction [CYP2C18 results in increased susceptibility to Ifosfamide]
CTD
PMID:9766669
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Pparg
peroxisome proliferator-activated receptor gamma
affects activity
ISO
Ifosfamide affects the activity of PPARG protein
CTD
PMID:25596134
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppfibp1
PPFIA binding protein 1
increases expression
ISO
Ifosfamide results in increased expression of PPFIBP1 mRNA
CTD
PMID:25596134
NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
G
Ppig
peptidylprolyl isomerase G
decreases expression
ISO
Ifosfamide results in decreased expression of PPIG mRNA
CTD
PMID:25596134
NCBI chr 3:54,484,023...54,512,929
Ensembl chr 3:54,484,023...54,512,926
G
Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
decreases expression
ISO
Ifosfamide results in decreased expression of PPM1D mRNA
CTD
PMID:25596134
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
G
Prc1
protein regulator of cytokinesis 1
increases expression
ISO
Ifosfamide results in increased expression of PRC1 mRNA
CTD
PMID:25596134
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
G
Prdm1
PR/SET domain 1
decreases expression
ISO
Ifosfamide results in decreased expression of PRDM1 mRNA
CTD
PMID:25596134
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
G
Prkab1
protein kinase AMP-activated non-catalytic subunit beta 1
affects expression
ISO
Ifosfamide affects the expression of PRKAB1 mRNA
CTD
PMID:25596134
NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
G
Prkab2
protein kinase AMP-activated non-catalytic subunit beta 2
affects expression
ISO
Ifosfamide affects the expression of PRKAB2 mRNA
CTD
PMID:25596134
NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872
G
Psat1
phosphoserine aminotransferase 1
increases expression
ISO
Ifosfamide results in increased expression of PSAT1 mRNA
CTD
PMID:25596134
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
G
Pspc1
paraspeckle component 1
decreases expression
ISO
Ifosfamide results in decreased expression of PSPC1 mRNA
CTD
PMID:25596134
NCBI chr15:30,828,617...30,911,315
Ensembl chr15:30,828,626...30,911,202
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
EXP
etoricoxib inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]; Indomethacin inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]; Pentoxifylline inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]; Thalidomide inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]
CTD
PMID:17638016
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Pycr1
pyrroline-5-carboxylate reductase 1
increases expression
ISO
Ifosfamide results in increased expression of PYCR1 mRNA
CTD
PMID:25596134
NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549
G
Pygl
glycogen phosphorylase L
decreases expression
ISO
Ifosfamide results in decreased expression of PYGL mRNA
CTD
PMID:25596134
NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
G
Rab31
RAB31, member RAS oncogene family
increases expression
ISO
Ifosfamide results in increased expression of RAB31 mRNA
CTD
PMID:25596134
NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253
G
Rffl
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
increases expression
ISO
Ifosfamide results in increased expression of RFFL mRNA
CTD
PMID:25596134
NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434
G
Rit1
Ras-like without CAAX 1
increases expression
ISO
Ifosfamide results in increased expression of RIT1 mRNA
CTD
PMID:25596134
NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455
G
Rlf
RLF zinc finger
increases expression
ISO
Ifosfamide results in increased expression of RLF mRNA
CTD
PMID:25596134
NCBI chr 5:134,711,612...134,767,274
Ensembl chr 5:134,711,619...134,767,257
G
Rnf121
ring finger protein 121
decreases expression
ISO
Ifosfamide results in decreased expression of RNF121 mRNA
CTD
PMID:25596134
NCBI chr 1:156,377,368...156,439,936
Ensembl chr 1:156,377,364...156,446,826
G
Ro60
Ro60, Y RNA binding protein
decreases expression
ISO
Ifosfamide results in decreased expression of RO60 mRNA
CTD
PMID:25596134
NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504
G
Rps27l
ribosomal protein S27-like
increases expression
ISO
Ifosfamide results in increased expression of RPS27L mRNA
CTD
PMID:25596134
NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418 Ensembl chr12:67,562,483...67,567,418 Ensembl chr 2:67,562,483...67,567,418
G
Rrm2b
ribonucleotide reductase regulatory TP53 inducible subunit M2B
decreases expression
ISO
Ifosfamide results in decreased expression of RRM2B mRNA
CTD
PMID:25596134
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
G
Rrp12
ribosomal RNA processing 12
increases expression
ISO
Ifosfamide results in increased expression of RRP12 mRNA
CTD
PMID:25596134
NCBI chr 1:240,672,378...240,705,992
Ensembl chr 1:240,672,382...240,706,018
G
Rsrc2
arginine and serine rich coiled-coil 2
decreases expression
ISO
Ifosfamide results in decreased expression of RSRC2 mRNA
CTD
PMID:25596134
NCBI chr12:32,839,840...32,859,820
Ensembl chr12:32,839,809...32,859,799
G
RT1-CE16
RT1 class I, locus CE16
affects expression
ISO
Ifosfamide affects the expression of HLA-A mRNA
CTD
PMID:25811541
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
G
RT1-M3-1
RT1 class Ib, locus M3, gene 1
affects expression
ISO
Ifosfamide affects the expression of HLA-G mRNA
CTD
PMID:25811541
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
G
Sars1
seryl-tRNA synthetase 1
increases expression
ISO
Ifosfamide results in increased expression of SARS1 mRNA
CTD
PMID:25596134
NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
G
Sertad1
SERTA domain containing 1
increases expression
ISO
Ifosfamide results in increased expression of SERTAD1 mRNA
CTD
PMID:25596134
NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
G
Sesn1
sestrin 1
increases expression
ISO
Ifosfamide results in increased expression of SESN1 mRNA
CTD
PMID:25596134
NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
G
Sfn
stratifin
increases expression
ISO
Ifosfamide results in increased expression of SFN mRNA
CTD
PMID:25596134
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
G
Sh3tc1
SH3 domain and tetratricopeptide repeats 1
decreases expression
ISO
Ifosfamide results in decreased expression of SH3TC1 mRNA
CTD
PMID:25596134
NCBI chr14:75,005,691...75,050,001
Ensembl chr14:75,016,875...75,049,995
G
Siah2
siah E3 ubiquitin protein ligase 2
increases expression
ISO
Ifosfamide results in increased expression of SIAH2 mRNA
CTD
PMID:25596134
NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950
G
Sipa1l2
signal-induced proliferation-associated 1 like 2
decreases expression
ISO
Ifosfamide results in decreased expression of SIPA1L2 mRNA
CTD
PMID:25596134
NCBI chr19:53,389,792...53,540,466
Ensembl chr19:53,389,805...53,540,428
G
Siva1
SIVA1, apoptosis-inducing factor
increases expression
ISO
Ifosfamide results in increased expression of SIVA1 mRNA
CTD
PMID:25596134
NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690
G
Slc12a8
solute carrier family 12, member 8
decreases expression
ISO
Ifosfamide results in decreased expression of SLC12A8 mRNA
CTD
PMID:25596134
NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834
G
Slc1a5
solute carrier family 1 member 5
increases expression
ISO
Ifosfamide results in increased expression of SLC1A5 mRNA
CTD
PMID:25596134
NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
G
Slc22a5
solute carrier family 22 member 5
decreases expression
EXP
Ifosfamide results in decreased expression of SLC22A5 mRNA; Ifosfamide results in decreased expression of SLC22A5 protein
CTD
PMID:22701146
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
G
Slc25a20
solute carrier family 25 member 20
increases expression
ISO
Ifosfamide results in increased expression of SLC25A20 mRNA
CTD
PMID:25596134
NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
G
Slc2a1
solute carrier family 2 member 1
increases expression
ISO
Ifosfamide results in increased expression of SLC2A1 mRNA
CTD
PMID:25596134
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
G
Slc3a2
solute carrier family 3 member 2
increases expression
ISO
Ifosfamide results in increased expression of SLC3A2 mRNA
CTD
PMID:25596134
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
G
Slc6a9
solute carrier family 6 member 9
decreases expression
ISO
Ifosfamide results in decreased expression of SLC6A9 mRNA
CTD
PMID:25596134
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
G
Slc7a5
solute carrier family 7 member 5
increases expression
ISO
Ifosfamide results in increased expression of SLC7A5 mRNA
CTD
PMID:25596134
NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
G
Son
SON DNA and RNA binding protein
decreases expression
ISO
Ifosfamide results in decreased expression of SON mRNA
CTD
PMID:25596134
NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167
G
Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
increases expression
ISO
Ifosfamide results in increased expression of SPSB1 mRNA
CTD
PMID:25596134
NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
G
Sqstm1
sequestosome 1
increases expression
ISO
Ifosfamide results in increased expression of SQSTM1 mRNA
CTD
PMID:25596134
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
G
Srd5a3
steroid 5 alpha-reductase 3
decreases expression
ISO
Ifosfamide results in decreased expression of SRD5A3 mRNA
CTD
PMID:25596134
NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747
G
Srxn1
sulfiredoxin 1
increases expression
ISO
Ifosfamide results in increased expression of SRXN1 mRNA
CTD
PMID:25596134
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
G
Sulf2
sulfatase 2
decreases expression
ISO
Ifosfamide results in decreased expression of SULF2 mRNA
CTD
PMID:25596134
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
G
Taldo1
transaldolase 1
increases expression
ISO
Ifosfamide results in increased expression of TALDO1 mRNA
CTD
PMID:25596134
NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
G
Tars1
threonyl-tRNA synthetase 1
decreases expression
ISO
Ifosfamide results in decreased expression of TARS1 mRNA
CTD
PMID:25596134
NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717
G
Tbxas1
thromboxane A synthase 1
increases expression
ISO
Ifosfamide results in increased expression of TBXAS1 mRNA
CTD
PMID:25596134
NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
G
Tfap2a
transcription factor AP-2 alpha
decreases expression
ISO
Ifosfamide results in decreased expression of TFAP2A mRNA
CTD
PMID:25596134
NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507
G
Thbs2
thrombospondin 2
decreases expression
ISO
Ifosfamide results in decreased expression of THBS2 mRNA
CTD
PMID:25596134
NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
G
Tigar
TP53 induced glycolysis regulatory phosphatase
increases expression
ISO
Ifosfamide results in increased expression of TIGAR mRNA
CTD
PMID:25596134
NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029 Ensembl chr 6:159,927,139...159,946,029
G
Timm17b
translocase of inner mitochondrial membrane 17b
decreases expression
ISO
Ifosfamide results in decreased expression of TIMM17B mRNA
CTD
PMID:25596134
NCBI chr X:14,596,330...14,603,491
Ensembl chr X:14,594,577...14,603,416
G
Tlr4
toll-like receptor 4
increases expression
ISO
Ifosfamide results in increased expression of TLR4 mRNA
CTD
PMID:25596134
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tmem94
transmembrane protein 94
decreases expression
ISO
Ifosfamide results in decreased expression of TMEM94 mRNA
CTD
PMID:25596134
NCBI chr10:100,991,523...101,027,046
Ensembl chr10:100,991,573...101,027,394
G
Tmtc2
transmembrane O-mannosyltransferase targeting cadherins 2
decreases expression
ISO
Ifosfamide results in decreased expression of TMTC2 mRNA
CTD
PMID:25596134
NCBI chr 7:40,392,377...40,806,685
Ensembl chr 7:40,394,220...40,807,298
G
Tnf
tumor necrosis factor
increases secretion multiple interactions increases expression
EXP
Ifosfamide results in increased secretion of TNF protein morin inhibits the reaction [Ifosfamide results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Ifosfamide results in increased secretion of TNF protein]
CTD
PMID:17481685 PMID:31722249
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfaip8
TNF alpha induced protein 8
increases expression
ISO
Ifosfamide results in increased expression of TNFAIP8 mRNA
CTD
PMID:25596134
NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517
G
Tnfsf9
TNF superfamily member 9
increases expression
ISO
Ifosfamide results in increased expression of TNFSF9 mRNA
CTD
PMID:25596134
NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
G
Top1
DNA topoisomerase I
increases expression
ISO
Ifosfamide results in increased expression of TOP1 mRNA
CTD
PMID:25596134
NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
G
Top2a
DNA topoisomerase II alpha
multiple interactions
ISO
TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide]
CTD
PMID:11325482
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
G
Tp53
tumor protein p53
affects activity increases expression multiple interactions
ISO EXP
Ifosfamide affects the activity of TP53 protein Ifosfamide results in increased expression of TP53 protein morin inhibits the reaction [Ifosfamide results in increased expression of TP53 protein]
CTD
PMID:25596134 PMID:31722249
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Tp53i3
tumor protein p53 inducible protein 3
increases expression
ISO
Ifosfamide results in increased expression of TP53I3 mRNA
CTD
PMID:25596134
NCBI chr 6:27,818,327...27,825,753
G
Tp53inp1
tumor protein p53 inducible nuclear protein 1
increases expression
ISO
Ifosfamide results in increased expression of TP53INP1 mRNA
CTD
PMID:25596134
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
G
Trafd1
TRAF type zinc finger domain containing 1
increases expression
ISO
Ifosfamide results in increased expression of TRAFD1 mRNA
CTD
PMID:25596134
NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525
G
Triap1
TP53 regulated inhibitor of apoptosis 1
increases expression
ISO
Ifosfamide results in increased expression of TRIAP1 mRNA
CTD
PMID:25596134
NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
G
Tspan12
tetraspanin 12
decreases expression
ISO
Ifosfamide results in decreased expression of TSPAN12 mRNA
CTD
PMID:25596134
NCBI chr 4:50,313,768...50,389,246
Ensembl chr 4:50,313,772...50,389,246
G
Txn1
thioredoxin 1
increases expression
ISO
Ifosfamide results in increased expression of TXN mRNA
CTD
PMID:25596134
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
G
Txnrd1
thioredoxin reductase 1
increases expression
ISO
Ifosfamide results in increased expression of TXNRD1 mRNA
CTD
PMID:25596134
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
G
Ube2g2
ubiquitin-conjugating enzyme E2G 2
increases expression
ISO
Ifosfamide results in increased expression of UBE2G2 mRNA
CTD
PMID:25596134
NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447
G
Unkl
unk like zinc finger
increases expression
ISO
Ifosfamide results in increased expression of UNKL mRNA
CTD
PMID:25596134
NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225
G
Usp3
ubiquitin specific peptidase 3
increases expression
ISO
Ifosfamide results in increased expression of USP3 mRNA
CTD
PMID:25596134
NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111
G
Vars1
valyl-tRNA synthetase 1
increases expression
ISO
Ifosfamide results in increased expression of VARS1 mRNA
CTD
PMID:25596134
NCBI chr20:3,805,774...3,820,468
Ensembl chr20:3,805,776...3,820,298
G
Vegfa
vascular endothelial growth factor A
multiple interactions decreases expression
ISO
IFNA2 promotes the reaction [Ifosfamide results in decreased expression of VEGFA protein]; IFNB1 promotes the reaction [Ifosfamide results in decreased expression of VEGFA protein]
CTD
PMID:15659795
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Wars1
tryptophanyl-tRNA synthetase 1
increases expression
ISO
Ifosfamide results in increased expression of WARS1 mRNA
CTD
PMID:25596134
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
G
Wwc2
WW and C2 domain containing 2
decreases expression
ISO
Ifosfamide results in decreased expression of WWC2 mRNA
CTD
PMID:25596134
NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812
G
Xbp1
X-box binding protein 1
affects activity
ISO
Ifosfamide affects the activity of XBP1 protein
CTD
PMID:25596134
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
G
Xpc
XPC complex subunit, DNA damage recognition and repair factor
increases expression
ISO
Ifosfamide results in increased expression of XPC mRNA
CTD
PMID:25596134
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
G
Yeats2
YEATS domain containing 2
affects expression
ISO
Ifosfamide affects the expression of YEATS2 mRNA
CTD
PMID:25596134
NCBI chr11:80,743,134...80,829,253
Ensembl chr11:80,743,134...80,829,208
G
Zmat3
zinc finger, matrin type 3
increases expression
ISO
Ifosfamide results in increased expression of ZMAT3 mRNA
CTD
PMID:25596134
NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all