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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ceftizoxime
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Accession:CHEBI:553473 term browser browse the term
Definition:A parenteral third-generation cephalosporin, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position.
Synonyms:exact_synonym: (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2,3-didehydropenam-2-carboxylic acid
 related_synonym: 7-[2-(2-Amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   CEFIZOX;   Formula=C13H13N5O5S2;   InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1;   InChIKey=NNULBSISHYWZJU-LLKWHZGFSA-N;   SMILES=[H][C@]12SCC=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\\c1csc(N)n1)C(O)=O;   ceftizoxima;   ceftizoximum;   syn-7-(2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-3-cephem-4-carboxylic acid
 alt_id: CHEBI:112105;   CHEBI:3511
 xref: CAS:68401-81-0;   DrugBank:DB01332;   Drug_Central:563;   KEGG:C06890;   KEGG:D07658
 xref_mesh: MESH:D015296
 xref: PMID:11452157;   PMID:11711261;   PMID:1384868;   PMID:15716453;   PMID:22726927;   PMID:23394621;   PMID:29017833;   Reaxys:5777502;   Wikipedia:Ceftizoxime
 cyclic_relationship: is_conjugate_acid_of CHEBI:55498


show annotations for term's descendants           Sort by:
ceftizoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase decreases activity ISO Ceftizoxime results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases uptake		 ISO Ceftizoxime inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
SLC22A6 protein results in increased uptake of Ceftizoxime		 CTD PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions		 ISO SLC22A8 protein results in increased uptake of Ceftizoxime
Ceftizoxime inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]		 CTD PMID:16098483 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        antimicrobial agent 18251
          antibacterial agent 16372
            antibacterial drug 7397
              ceftizoxime 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  carbon oxoacid 18660
                                    carboxylic acid 18657
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17551
                                            carboxamide 17551
                                              lactam 8389
                                                beta-lactam 831
                                                  beta-lactam antibiotic 816
                                                    cephem 550
                                                      cephalosporin 549
                                                        ceftizoxime 3
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