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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gastrointestinal drug
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Accession:CHEBI:55324 term browser browse the term
Definition:A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion.
Synonyms:related_synonym: gastrointestinal agent;   gastrointestinal agents;   gastrointestinal drugs


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16,16-dimethylprostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions 		ISO 16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein
EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein] 		CTD PMID:15578100 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance
affects localization 		ISO BAX results in increased susceptibility to 16,16-Dimethylprostaglandin E2
16,16-Dimethylprostaglandin E2 affects the localization of BAX protein 		CTD PMID:15578100 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein] CTD PMID:15578100 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity ISO 16,16-Dimethylprostaglandin E2 results in increased activity of HPGD protein CTD PMID:14736730 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11686837 PMID:11855677 PMID:11991626 PMID:18306037 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:11686837 PMID:11855677 PMID:11991626 PMID:15610444 PMID:18306037 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression 		ISO
EXP 		Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]
16,16-Dimethylprostaglandin E2 inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA] 		CTD PMID:9099957 PMID:15610444 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 16,16-Dimethylprostaglandin E2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] CTD PMID:9298541 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
3,7,12-trioxo-5beta-cholanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Dehydrocholic Acid CTD PMID:30926317 NCBI chr10:70,195,637...70,205,735
Ensembl chr10:70,195,637...70,205,893 		JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682 		JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr11:95,689,702...95,714,980
Ensembl chr11:95,689,919...95,714,981 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:109,114,322...109,134,855 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:129,639,736...129,644,891 		JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359 		JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563 		JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr 1:241,840,898...241,896,451
Ensembl chr 1:241,840,987...241,896,451 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:30,715,602...30,733,746 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr13:42,379,161...42,404,352
Ensembl chr13:42,379,162...42,465,467 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr 9:1,220,162...1,241,792
Ensembl chr 9:1,222,063...1,241,792 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
balsalazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase decreases activity ISO balsalazide results in decreased activity of MPO protein CTD PMID:19296261 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
ceruletide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression 		ISO PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of ACTA2 mRNA]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of ACTA2 protein]
Ceruletide results in increased expression of ACTA2 mRNA; Ceruletide results in increased expression of ACTA2 protein 		CTD PMID:25035110 PMID:38113986 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Ahcy adenosylhomocysteinase decreases expression EXP Ceruletide results in decreased expression of AHCY protein CTD PMID:18024178 NCBI chr 3:164,029,338...164,044,562
Ensembl chr 3:164,029,338...164,044,587 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression EXP Ceruletide results in increased expression of AKR1B1 protein CTD PMID:18024178 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein CTD PMID:26390243 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alb albumin decreases expression EXP Ceruletide results in decreased expression of ALB protein modified form CTD PMID:17169977 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO [2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of ATF4 protein CTD PMID:38407484 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions 		ISO Ceruletide results in increased expression of BCL2 mRNA; Ceruletide results in increased expression of BCL2 protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of BCL2 protein] 		CTD PMID:34423886 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdkrb1 bradykinin receptor B1 increases expression ISO Ceruletide results in increased expression of BDKRB1 mRNA CTD PMID:21484880 NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973 		JBrowse link
G Bdkrb2 bradykinin receptor B2 increases expression ISO Ceruletide results in increased expression of BDKRB2 mRNA CTD PMID:21484880 NCBI chr 6:130,237,055...130,267,205
Ensembl chr 6:130,237,255...130,267,209 		JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein CTD PMID:26390243 NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,866,997...11,946,923 		JBrowse link
G Casp1 caspase 1 increases cleavage
multiple interactions 		EXP Ceruletide results in increased cleavage of CASP1 protein
Acetylcysteine inhibits the reaction [Ceruletide results in increased cleavage of CASP1 protein]; Acetylcysteine promotes the reaction [saikosaponin D inhibits the reaction [Ceruletide results in increased cleavage of CASP1 protein]]; saikosaponin D inhibits the reaction [Ceruletide results in increased cleavage of CASP1 protein] 		CTD PMID:38462915 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Glycodeoxycholic Acid co-treated with Ceruletide] results in decreased activity of CASP3 protein; Ceruletide results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:16339139 PMID:18832452 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP Ceruletide results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16339139 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Ceruletide results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16339139 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression 		ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]]; limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]; PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]; Rosiglitazone inhibits the reaction [Ceruletide results in increased expression of CCL2 mRNA] CTD PMID:17463185 PMID:21484880 PMID:34423886 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression 		ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of CCND1 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]
Ceruletide results in increased expression of CCND1 mRNA; Ceruletide results in increased expression of CCND1 protein 		CTD PMID:34423886 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 increases expression EXP Ceruletide results in increased expression of CCT2 protein CTD PMID:18024178 NCBI chr 7:54,578,654...54,591,428
Ensembl chr 7:54,578,663...54,592,977 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression
multiple interactions 		EXP Ceruletide results in increased expression of CEBPA mRNA
[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPA mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPA mRNA] 		CTD PMID:26873426 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
increases expression 		EXP [Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPB mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPB mRNA] CTD PMID:26873426 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cgas cyclic GMP-AMP synthase multiple interactions
increases expression 		EXP Acetylcysteine inhibits the reaction [Ceruletide results in increased expression of CGAS protein]; Acetylcysteine promotes the reaction [saikosaponin D inhibits the reaction [Ceruletide results in increased expression of CGAS protein]]; saikosaponin D inhibits the reaction [Ceruletide results in increased expression of CGAS protein] CTD PMID:38462915 NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:88,174,512...88,185,859 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression 		ISO
EXP 		PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]
PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA] 		CTD PMID:22280800 PMID:25035110 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Crp C-reactive protein increases activity
multiple interactions 		EXP Ceruletide results in increased activity of CRP protein
saikosaponin D inhibits the reaction [Ceruletide results in increased activity of CRP protein] 		CTD PMID:38462915 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Ctsb cathepsin B affects localization
multiple interactions 		EXP Ceruletide affects the localization of CTSB protein
sodium arsenite inhibits the reaction [Ceruletide affects the localization of CTSB protein] 		CTD PMID:17941083 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions 		ISO Ceruletide results in increased expression of CXCL1 mRNA
AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; AM 251 promotes the reaction [iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; HU 211 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline promotes the reaction [AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA] 		CTD PMID:17463185 PMID:17484889 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of DDIT3 protein CTD PMID:38407484 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP Ceruletide results in increased expression of DUSP1 mRNA CTD PMID:11027531 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression EXP Ceruletide results in increased expression of DUSP10 mRNA CTD PMID:11027531 NCBI chr13:98,145,317...98,183,304
Ensembl chr13:98,145,893...98,183,304 		JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression EXP Ceruletide results in increased expression of DUSP6 mRNA CTD PMID:11027531 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO [2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:38407484 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression
multiple interactions 		EXP Ceruletide results in increased expression of ERN1 mRNA; Ceruletide results in increased expression of ERN1 protein
Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 protein] 		CTD PMID:26873426 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression EXP Ceruletide results in increased expression of GLUD1 protein CTD PMID:18024178 NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression 		ISO isoborneol inhibits the reaction [Ceruletide results in increased expression of GPT protein] CTD PMID:33166053 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions 		ISO Ceruletide results in increased expression of HMOX1 protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein] 		CTD PMID:34423886 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 increases expression EXP Ceruletide results in increased expression of HNRNPH1 protein CTD PMID:18024178 NCBI chr10:35,187,412...35,203,909
Ensembl chr10:35,193,890...35,203,906 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression EXP Ceruletide results in decreased expression of HSPA5 protein CTD PMID:18024178 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression EXP Ceruletide results in decreased expression of HSPA8 protein CTD PMID:18024178 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372 		JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression EXP Ceruletide results in increased expression of HYOU1 protein CTD PMID:18024178 NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:53,602,604...53,614,997 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression 		ISO PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]
rosiglitazone inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA] 		CTD PMID:17463185 PMID:25035110 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [resveratrol co-treated with Ceruletide] results in increased expression of IL10 protein CTD PMID:24234420 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il18 interleukin 18 increases secretion
multiple interactions 		EXP Ceruletide results in increased secretion of IL18 protein
saikosaponin D inhibits the reaction [Ceruletide results in increased secretion of IL18 protein] 		CTD PMID:38462915 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions 		EXP
ISO 		Ceruletide results in increased expression of IL1B mRNA; Ceruletide results in increased expression of IL1B protein
Ceruletide results in increased secretion of IL1B protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]
Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL1B protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]; saikosaponin D inhibits the reaction [Ceruletide results in increased secretion of IL1B protein] 		CTD PMID:14751415 PMID:21484880 PMID:24234420 PMID:26873426 PMID:33166053 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
multiple interactions 		ISO
EXP 		Ceruletide results in increased expression of IL6 mRNA
Ceruletide results in increased secretion of IL6 protein
Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL6 protein]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]]
(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]]; HU 211 inhibits the reaction [Ceruletide results in increased expression of IL6 protein]; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of IL6 protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of IL6 protein]
Ceruletide results in increased expression of IL6 mRNA; Ceruletide results in increased expression of IL6 protein
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA] 		CTD PMID:17484889 PMID:22280800 PMID:25035110 PMID:26390243 PMID:26873426 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions
increases expression 		ISO coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of JAK2 protein] CTD PMID:34423886 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions 		ISO Ceruletide results in increased expression of JUN mRNA
rosiglitazone inhibits the reaction [Ceruletide results in increased expression of JUN mRNA] 		CTD PMID:17463185 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]] CTD PMID:26390243 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of and results in increased phosphorylation of MAPK8 protein CTD PMID:38407484 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mir216a microRNA 216a increases expression EXP Ceruletide results in increased expression of MIR216A mRNA CTD PMID:27521901 NCBI chr14:106,725,077...106,725,182
Ensembl chr14:106,725,077...106,725,182 		JBrowse link
G Mir216b microRNA 216b increases expression EXP Ceruletide results in increased expression of MIR216B mRNA CTD PMID:27521901 NCBI chr14:106,714,026...106,714,127
Ensembl chr14:106,714,026...106,714,127 		JBrowse link
G Mir217 microRNA 217 increases expression EXP Ceruletide results in increased expression of MIR217 mRNA CTD PMID:27521901 NCBI chr14:106,732,485...106,732,589
Ensembl chr14:106,732,485...106,732,589 		JBrowse link
G Mpo myeloperoxidase increases expression
increases activity
multiple interactions 		ISO Ceruletide results in increased expression of MPO protein
Ceruletide results in increased activity of MPO protein
HU 211 inhibits the reaction [Ceruletide results in increased expression of MPO protein]; isoborneol inhibits the reaction [Ceruletide results in increased activity of MPO protein] 		CTD PMID:17484889 PMID:33166053 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression 		ISO isoborneol inhibits the reaction [Ceruletide results in decreased expression of NFE2L2 protein] CTD PMID:33166053 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases degradation
multiple interactions 		EXP Ceruletide results in increased degradation of NFKBIA protein
sodium arsenite inhibits the reaction [Ceruletide results in increased degradation of NFKBIA protein] 		CTD PMID:17941083 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression 		EXP Acetylcysteine inhibits the reaction [Ceruletide results in increased expression of NLRP3 protein]; Acetylcysteine promotes the reaction [saikosaponin D inhibits the reaction [Ceruletide results in increased expression of NLRP3 protein]]; saikosaponin D inhibits the reaction [Ceruletide results in increased expression of NLRP3 protein] CTD PMID:38462915 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions 		ISO Ceruletide results in increased expression of NOS2 protein
isoborneol inhibits the reaction [Ceruletide results in increased expression of NOS2 protein] 		CTD PMID:33166053 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 increases expression EXP Ceruletide results in increased expression of PDIA4 protein CTD PMID:18024178 NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:78,134,144...78,153,191 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA] CTD PMID:17463185 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prdx2 peroxiredoxin 2 increases expression EXP Ceruletide results in increased expression of PRDX2 protein CTD PMID:18024178 NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ceruletide results in increased expression of PTGS2 mRNA; Ceruletide results in increased expression of PTGS2 protein CTD PMID:14751415 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions
affects response to substance
increases expression 		ISO
EXP 		PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
Ethanol results in increased susceptibility to [Ceruletide results in increased expression of PTHLH mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]
PTHLH protein affects the susceptibility to Ceruletide
Ceruletide results in increased expression of PTHLH mRNA; Ceruletide results in increased expression of PTHLH protein
PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA] 		CTD PMID:22280800 PMID:25035110 NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
increases expression 		ISO ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate inhibits the reaction [Ceruletide results in increased expression of RELA protein]; isoborneol inhibits the reaction [Ceruletide results in decreased phosphorylation of RELA protein] CTD PMID:22982818 PMID:33166053 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases cleavage EXP Ceruletide results in increased cleavage of RIPK1 protein CTD PMID:16339139 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167 		JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 increases expression EXP Ceruletide results in increased expression of RUVBL1 protein CTD PMID:18024178 NCBI chr 4:122,489,754...122,524,666
Ensembl chr 4:122,489,680...122,524,665 		JBrowse link
G Serpinf1 serpin family F member 1 increases activity EXP cerulein increases activity of Serpinf1 protein in blood RGD PMID:10423332 RGD:1625538 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO [Shuangshen co-treated with Ceruletide] results in decreased expression of SMAD2 protein CTD PMID:38113986 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smad3 SMAD family member 3 increases expression
multiple interactions 		ISO Ceruletide results in increased expression of SMAD3 protein
Shuangshen inhibits the reaction [Ceruletide results in increased expression of SMAD3 protein] 		CTD PMID:38113986 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression 		ISO
EXP 		isoborneol inhibits the reaction [Ceruletide results in decreased expression of SOD1 protein]
saikosaponin D inhibits the reaction [Ceruletide results in decreased expression of SOD1 protein] 		CTD PMID:33166053 PMID:38462915 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation 		ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]]; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]; limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein] CTD PMID:26390243 PMID:34423886 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 increases expression
multiple interactions 		EXP Ceruletide results in increased expression of STING1 protein
Acetylcysteine inhibits the reaction [Ceruletide results in increased expression of STING1 protein]; Acetylcysteine promotes the reaction [saikosaponin D inhibits the reaction [Ceruletide results in increased expression of STING1 protein]]; saikosaponin D inhibits the reaction [Ceruletide results in increased expression of STING1 protein] 		CTD PMID:38462915 NCBI chr18:27,606,196...27,612,544
Ensembl chr18:27,606,196...27,611,947 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression 		ISO Shuangshen inhibits the reaction [Ceruletide results in increased expression of TGFB1 protein] CTD PMID:38113986 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
multiple interactions 		EXP
ISO 		Ceruletide results in increased expression of TNF mRNA; Ceruletide results in increased expression of TNF protein
Ceruletide results in increased secretion of TNF protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of TNF protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of TNF protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of TNF protein]
2-acetoxy-5-(2-4-(trifluoromethyl)phenethylamino)benzoic acid inhibits the reaction [[Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; [Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; arsenic trioxide inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Ceruletide results in increased expression of TNF protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]] 		CTD PMID:10773043 PMID:17517186 PMID:22575522 PMID:26873426 PMID:33166053 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Ceruletide results in increased expression of TPI1 protein CTD PMID:18024178 NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413 		JBrowse link
G Vcp valosin-containing protein decreases expression EXP Ceruletide results in decreased expression of VCP protein CTD PMID:18024178 NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:62,005,985...62,025,387 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions 		EXP Ceruletide results in increased expression of XBP1 mRNA alternative form; Ceruletide results in increased expression of XBP1 protein alternative form
Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 protein alternative form] 		CTD PMID:26873426 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Xiap X-linked inhibitor of apoptosis increases degradation EXP Ceruletide results in increased degradation of XIAP protein CTD PMID:16339139 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
cisapride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Cisapride results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:31150804 NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:31150804 NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
affects chemical synthesis
decreases activity 		ISO Cisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein affects the metabolism of Cisapride
CYP3A4 protein affects the chemical synthesis of Cisapride metabolite
Cisapride results in decreased activity of CYP3A4 protein 		CTD PMID:11717173 PMID:15306208 PMID:19299527 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:31150804 NCBI chr 7:72,692,364...72,706,983
Ensembl chr 7:72,671,477...72,707,009 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:31150804 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects localization
affects binding 		ISO beta-Cyclodextrins analog inhibits the reaction [Cisapride results in decreased activity of KCNH2 protein]; Cisapride binds to and results in decreased activity of KCNH2 protein; Cisapride inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Cisapride affects the localization of KCNH2 protein mutant form
Cisapride binds to KCNH2 protein 		CTD PMID:9395068 PMID:10531299 PMID:11005845 PMID:11741928 PMID:12388285 More... NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:31150804 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 increases localization ISO Cisapride results in increased localization of SCN5A protein mutant form CTD PMID:16301357 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cisapride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:31150804 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
cyproheptadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression EXP Cyproheptadine results in increased expression of CASP3 protein CTD PMID:33675893 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Cyproheptadine results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Gh1 growth hormone 1 increases expression ISO Cyproheptadine results in increased expression of GH1 protein CTD PMID:642945 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Cyproheptadine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO Cyproheptadine binds to and results in decreased activity of HTR2A protein CTD PMID:17031071 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions 		ISO Cyproheptadine binds to HTR7 protein
Cyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein] 		CTD PMID:20827463 NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:243,049,081...243,173,230 		JBrowse link
G Il6 interleukin 6 decreases expression EXP Cyproheptadine results in decreased expression of IL6 protein CTD PMID:33675893 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Cyproheptadine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:40,004,693...40,445,043
Ensembl chr18:40,155,939...40,445,045 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression EXP Cyproheptadine results in decreased expression of NFKB1 protein CTD PMID:33675893 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Pomc proopiomelanocortin decreases secretion ISO Cyproheptadine results in decreased secretion of POMC protein CTD PMID:642945 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Prl prolactin decreases secretion ISO Cyproheptadine results in decreased secretion of PRL protein CTD PMID:642945 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Sirt1 sirtuin 1 increases expression EXP Cyproheptadine results in increased expression of SIRT1 protein CTD PMID:33675893 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cyproheptadine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine] CTD PMID:19821448 NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077 		JBrowse link
devazepide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amy2a3 amylase 2a3 multiple interactions EXP Devazepide inhibits the reaction [Melatonin results in increased secretion of AMY2A3 protein] CTD PMID:15009505 NCBI chr 2:204,005,840...204,014,412
Ensembl chr 2:204,005,840...204,014,413 		JBrowse link
G Cck cholecystokinin multiple interactions ISO Devazepide promotes the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]]; Devazepide promotes the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of TNF protein]] CTD PMID:32916201 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686 		JBrowse link
G Cckar cholecystokinin A receptor multiple interactions ISO Devazepide inhibits the reaction [CCKAR protein results in increased susceptibility to denatonium] CTD PMID:18003792 NCBI chr14:61,505,270...61,513,618
Ensembl chr14:61,505,270...61,513,618 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Devazepide inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased expression of FOS protein] CTD PMID:9372230 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Devazepide promotes the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]] CTD PMID:32916201 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Devazepide promotes the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of TNF protein]] CTD PMID:32916201 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
diphenoxylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO Diphenoxylate affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
eluxadoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to eluxadoline CTD PMID:25261794 NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999 		JBrowse link
kaolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F11 coagulation factor XI decreases activity ISO Kaolin results in decreased activity of F11 protein CTD PMID:6604052 NCBI chr16:53,720,502...53,741,547
Ensembl chr16:53,718,621...53,740,941 		JBrowse link
G F12 coagulation factor XII increases activity ISO Kaolin results in increased activity of F12 protein CTD PMID:6343536 NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,212,819...9,220,664 		JBrowse link
lactulose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag3 BAG cochaperone 3 increases expression ISO Lactulose results in increased expression of BAG3 mRNA CTD PMID:30335591 NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of CASP3 protein modified form]; Lactulose inhibits the reaction [Thioacetamide results in increased expression of CASP3 protein] CTD PMID:30450033 PMID:35961375 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of EGFR mRNA]; Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of EGFR protein] CTD PMID:36414212 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of GPT protein] CTD PMID:36414212 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Lactulose results in increased expression of HMOX1 mRNA CTD PMID:30450033 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hp haptoglobin multiple interactions EXP Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of HP protein] CTD PMID:36414212 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518 		JBrowse link
G Hspb8 heat shock protein family B (small) member 8 increases expression ISO Lactulose results in increased expression of HSPB8 mRNA CTD PMID:30335591 NCBI chr12:45,835,899...45,866,449
Ensembl chr12:45,837,066...45,851,937 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of IL1B protein] CTD PMID:30450033 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; Lactulose inhibits the reaction [Methamphetamine results in increased expression of IL6 protein] CTD PMID:30450033 PMID:36414212 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO Lactulose results in increased expression of MAP1LC3B mRNA CTD PMID:30335591 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions EXP Lactulose inhibits the reaction [Thioacetamide results in increased expression of MAP3K5 protein] CTD PMID:35961375 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Lactulose inhibits the reaction [Thioacetamide results in increased expression of MAPK8 protein] CTD PMID:35961375 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Maz MYC associated zinc finger protein multiple interactions EXP Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of MAZ mRNA]; Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of MAZ protein] CTD PMID:36414212 NCBI chr 1:191,060,271...191,065,722
Ensembl chr 1:191,060,280...191,065,339 		JBrowse link
G Mir34c microRNA 34c multiple interactions EXP Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in increased expression of MIR34C mRNA] CTD PMID:36414212 NCBI chr 8:60,306,091...60,306,167 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of MYD88 protein] CTD PMID:30450033 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Lactulose promotes the reaction [Methamphetamine results in increased expression of NFE2L2 mRNA] CTD PMID:30450033 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Lactulose inhibits the reaction [Thioacetamide results in increased expression of NFKB1 protein] CTD PMID:35961375 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Ocln occludin multiple interactions EXP Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of OCLN mRNA]; Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of OCLN protein] CTD PMID:36414212 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of PARP1 protein modified form] CTD PMID:30450033 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Lactulose inhibits the reaction [Thioacetamide results in decreased phosphorylation of PIK3R1 protein] CTD PMID:35961375 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of RELA protein] CTD PMID:30450033 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression 		EXP
ISO 		Lactulose promotes the reaction [Methamphetamine results in increased expression of SQSTM1 mRNA]
Lactulose results in increased expression of SQSTM1 mRNA 		CTD PMID:30335591 PMID:30450033 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Tfeb transcription factor EB affects localization
multiple interactions 		ISO Lactulose affects the localization of TFEB protein
Cyclosporine inhibits the reaction [Lactulose affects the localization of TFEB protein] 		CTD PMID:30335591 NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of TJP1 mRNA]; Lactulose inhibits the reaction [[Thioacetamide co-treated with Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of TJP1 protein] CTD PMID:36414212 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein] CTD PMID:30450033 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		Lactulose inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Lactulose inhibits the reaction [Methamphetamine results in increased expression of TNF protein]; Lactulose inhibits the reaction [Thioacetamide results in increased expression of TNF protein] 		CTD PMID:2311978 PMID:30450033 PMID:35961375 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions EXP Lactulose inhibits the reaction [Methamphetamine results in increased expression of TRAF6 protein] CTD PMID:30450033 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 increases expression ISO Lactulose results in increased expression of ZKSCAN3 mRNA CTD PMID:30335591 NCBI chr17:47,912,816...47,928,553
Ensembl chr17:47,912,912...47,928,551 		JBrowse link
loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Loperamide results in decreased expression of ABCB11 mRNA CTD PMID:35926757 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
decreases expression
multiple interactions
increases transport
affects response to substance 		ISO Loperamide binds to ABCB1 protein
Loperamide results in decreased expression of ABCB1 mRNA
Loperamide inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]
ABCB1 protein results in increased transport of Loperamide
ABCB1A protein affects the susceptibility to Loperamide 		CTD PMID:15502009 PMID:23976943 PMID:34719826 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Loperamide CTD PMID:15502009 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Loperamide results in decreased expression of ABCC2 mRNA CTD PMID:35926757 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO Loperamide results in decreased expression of ABCG5 mRNA CTD PMID:35926757 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376 		JBrowse link
G Ano1 anoctamin 1 decreases expression
multiple interactions 		ISO Loperamide results in decreased expression of ANO1 mRNA; Loperamide results in decreased expression of ANO1 protein
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 protein] 		CTD PMID:37375548 NCBI chr 1:209,180,755...209,329,413
Ensembl chr 1:209,180,755...209,329,550 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression 		ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]
Loperamide results in decreased expression of BCL2 mRNA 		CTD PMID:34719826 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Cat catalase decreases expression EXP Loperamide results in decreased expression of CAT protein CTD PMID:30597669 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions 		ISO Loperamide results in increased expression of CDKN1A mRNA
Loperamide promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA] 		CTD PMID:34719826 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Ces2h carboxylesterase 2H decreases activity
multiple interactions 		ISO Loperamide results in decreased activity of CES2 protein
[Loperamide results in decreased activity of CES2 protein] which results in increased susceptibility to Bisphenol A-Glycidyl Methacrylate 		CTD PMID:15687373 PMID:21951919 PMID:28647665 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752 		JBrowse link
G Ch25h cholesterol 25-hydroxylase increases expression ISO Loperamide results in increased expression of CH25H mRNA CTD PMID:35926757 NCBI chr 1:241,428,048...241,429,366
Ensembl chr 1:241,331,619...241,431,190 		JBrowse link
G Ckb creatine kinase B multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Loperamide results in increased expression of CYP7A1 mRNA CTD PMID:35926757 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression ISO Loperamide results in increased expression of FABP6 mRNA CTD PMID:35926757 NCBI chr10:28,565,054...28,569,727
Ensembl chr10:28,565,054...28,573,058 		JBrowse link
G Fdps farnesyl diphosphate synthase increases expression ISO Loperamide results in increased expression of FDPS mRNA CTD PMID:35926757 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases secretion EXP Loperamide results in increased secretion of GOT1 protein CTD PMID:30597669 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Loperamide results in increased expression of HMGCR mRNA CTD PMID:35926757 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions
decreases expression 		ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA] CTD PMID:37375548 NCBI chr18:58,036,277...58,221,327
Ensembl chr18:58,036,277...58,219,622 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Loperamide results in increased expression of IDI1 mRNA CTD PMID:35926757 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Loperamide results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il4 interleukin 4 increases expression ISO Loperamide results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Lss lanosterol synthase increases expression ISO Loperamide results in increased expression of LSS mRNA CTD PMID:35926757 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
multiple interactions 		ISO Loperamide results in decreased expression of MAPK8 mRNA
Loperamide promotes the reaction [Doxorubicin results in decreased expression of MAPK8 mRNA] 		CTD PMID:34719826 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression 		ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of MTOR mRNA]
Loperamide results in decreased expression of MTOR mRNA 		CTD PMID:34719826 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Mvk mevalonate kinase increases expression ISO Loperamide results in increased expression of MVK mRNA CTD PMID:35926757 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503 		JBrowse link
G Mylk myosin light chain kinase decreases expression
multiple interactions 		ISO Loperamide results in decreased expression of MYLK mRNA
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA] 		CTD PMID:37375548 NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Loperamide results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression 		ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of NOS1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of NOS1 protein] CTD PMID:37375548 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Loperamide binds to and results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to Loperamide CTD PMID:25261794 NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999 		JBrowse link
G Pld2 phospholipase D2 increases activity ISO Loperamide results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435 		JBrowse link
G Ryr3 ryanodine receptor 3 decreases expression
multiple interactions 		ISO Loperamide results in decreased expression of RYR3 mRNA
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA] 		CTD PMID:37375548 NCBI chr 3:119,886,129...120,433,465
Ensembl chr 3:119,885,878...120,433,677 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Loperamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc51a solute carrier family 51 member A increases expression ISO Loperamide results in increased expression of SLC51A mRNA CTD PMID:35926757 NCBI chr11:81,804,141...81,818,539
Ensembl chr11:81,803,972...81,818,539 		JBrowse link
G Sqle squalene epoxidase increases expression ISO Loperamide results in increased expression of SQLE mRNA CTD PMID:35926757 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion EXP Loperamide results in increased secretion of TNNI3 protein CTD PMID:30597669 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253 		JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 multiple interactions
decreases expression 		ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of TRPM7 protein] CTD PMID:37375548 NCBI chr 3:134,499,617...134,588,113
Ensembl chr 3:134,499,617...134,588,113 		JBrowse link
metoclopramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Metoclopramide CTD PMID:15502009 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Metoclopramide CTD PMID:15502009 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Metoclopramide binds to and results in decreased activity of ACHE protein; Metoclopramide inhibits the reaction [mipafox binds to and results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [mipafox results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein] CTD PMID:12518340 PMID:14635269 PMID:15052610 PMID:16193528 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Metoclopramide results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:80,758,641...80,837,891
Ensembl chr 8:80,758,142...80,837,883 		JBrowse link
G Amy2a3 amylase 2a3 multiple interactions EXP Metoclopramide inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:204,005,840...204,014,412
Ensembl chr 2:204,005,840...204,014,413 		JBrowse link
G Ar androgen receptor affects expression
increases expression
multiple interactions 		EXP Metoclopramide affects the expression of AR protein
Metoclopramide results in increased expression of AR protein
[Metoclopramide results in decreased abundance of Testosterone] which results in decreased expression of AR protein 		CTD PMID:14655152 PMID:16529173 PMID:16584088 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Avp arginine vasopressin multiple interactions ISO Metoclopramide inhibits the reaction [Apomorphine results in increased expression of AVP protein] CTD PMID:16575035 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522 		JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO Metoclopramide inhibits the reaction [mipafox binds to and results in decreased activity of BCHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of BCHE protein] CTD PMID:12518340 PMID:15052610 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Metoclopramide inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein]; Metoclopramide inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased activity of and results in increased cleavage of CASP3 protein]; Metoclopramide inhibits the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:29027213 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
affects binding 		EXP [Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol; Metoclopramide inhibits the reaction [4-diphenylacetoxy-N-methylpiperidine methobromide binds to CHRM3 protein]
Metoclopramide binds to CHRM3 protein 		CTD PMID:15105209 NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of CXCL2 mRNA] CTD PMID:21691039 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of CXCL1 mRNA] CTD PMID:21691039 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Metoclopramide results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 gene polymorphism affects the metabolism of Metoclopramide CTD PMID:16702617 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
increases expression 		ISO
EXP 		Metoclopramide binds to and results in decreased activity of DRD2 protein
Metoclopramide binds to DRD2 protein
Metoclopramide results in increased expression of DRD2 protein 		CTD PMID:1930352 PMID:9808703 PMID:11561213 PMID:12130853 PMID:12593651 More... NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [Metoclopramide co-treated with Estradiol] results in decreased expression of ESR1 protein CTD PMID:11786374 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Gcg glucagon increases secretion ISO Metoclopramide results in increased secretion of GCG protein CTD PMID:20829521 NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:67,522,489...67,531,533 		JBrowse link
G Gip gastric inhibitory polypeptide increases secretion ISO Metoclopramide results in increased secretion of GIP protein CTD PMID:20829521 NCBI chr10:81,465,070...81,473,216
Ensembl chr10:81,465,062...81,473,216 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
affects binding
decreases activity 		ISO
EXP 		[Dexamethasone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; [Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; Metoclopramide binds to and results in decreased activity of HTR3A protein; Metoclopramide inhibits the reaction [GR 65630 binds to HTR3A protein]
Metoclopramide binds to HTR3A protein
Metoclopramide results in decreased activity of HTR3A protein 		CTD PMID:12130853 PMID:12593651 PMID:15329590 PMID:16041395 PMID:17201744 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884 		JBrowse link
G Ins2 insulin 2 multiple interactions
increases expression 		ISO Dopamine promotes the reaction [Metoclopramide results in increased expression of INS protein] CTD PMID:18645345 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Metoclopramide results in decreased activity of KCNH2 protein CTD PMID:15640612 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression ISO Metoclopramide results in increased expression of LHB protein CTD PMID:2880862 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:21691039 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:21691039 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased cleavage of PARP1 protein] CTD PMID:29027213 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Prl prolactin multiple interactions
increases expression
increases secretion
affects expression 		ISO
EXP 		Lisuride inhibits the reaction [Metoclopramide results in increased secretion of PRL protein]; Metoclopramide results in increased expression of and results in increased secretion of PRL protein
Metoclopramide results in increased expression of PRL protein
Metoclopramide affects the expression of PRL protein 		CTD PMID:386688 PMID:1304515 PMID:1304992 PMID:2635674 PMID:3962302 More... NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Prlr prolactin receptor increases expression ISO Metoclopramide results in increased expression of PRLR mRNA; Metoclopramide results in increased expression of PRLR mRNA alternative form CTD PMID:19304288 NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Metoclopramide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression EXP Metoclopramide results in increased expression of SRD5A1 mRNA CTD PMID:18978642 NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 increases expression EXP Metoclopramide results in increased expression of SRD5A2 mRNA CTD PMID:18978642 NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:27,178,079...27,217,588 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Metoclopramide inhibits the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:29027213 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
rifaximin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression 		ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of ABCB1A mRNA
rifaximin results in increased expression of ABCB1 mRNA 		CTD PMID:21141967 PMID:22790967 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of ACTA2 mRNA CTD PMID:22790967 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Apoa4 apolipoprotein A4 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of APOA4 mRNA CTD PMID:22790967 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL3 protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL3 protein] CTD PMID:21599020 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CD36 protein CTD PMID:22790967 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cfd complement factor D multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CFD mRNA CTD PMID:22790967 NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:10,463,775...10,465,572 		JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CIDEC mRNA CTD PMID:22790967 NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of COL1A1 mRNA CTD PMID:22790967 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Rifaximin results in increased expression of CYP3A4 mRNA CTD PMID:21141967 PMID:27506419 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CYP7A1 protein CTD PMID:22790967 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of CYP7B1 protein CTD PMID:22790967 NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of DGAT2 mRNA CTD PMID:22790967 NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566 		JBrowse link
G Fabp2 fatty acid binding protein 2 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of FABP2 protein CTD PMID:22790967 NCBI chr 2:213,724,629...213,728,686
Ensembl chr 2:213,724,629...213,728,686 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein] CTD PMID:21599020 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [rifaximin co-treated with Trinitrobenzenesulfonic Acid] results in increased expression of IL10 protein CTD PMID:21599020 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Lta lymphotoxin alpha multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of LTA mRNA CTD PMID:22790967 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein] CTD PMID:21599020 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of NR1H4 protein CTD PMID:22790967 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
increases expression
increases response to substance 		ISO [NR1I2 results in increased susceptibility to Rifaximin] which results in increased abundance of Triglycerides; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of ABCB1A mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of ACTA2 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of APOA4 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CD36 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CFD mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CIDEC mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of COL1A1 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CYP3A11 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CYP7A1 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of CYP7B1 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of DGAT2 mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of FABP2 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of LTA mRNA; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of NR1H4 protein; [NR1I2 results in increased susceptibility to Rifaximin] which results in increased expression of PPARG mRNA; [Rifaximin binds to and results in increased activity of NR1I2 protein] which results in decreased susceptibility to Trinitrobenzenesulfonic Acid; bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate inhibits the reaction [Rifaximin results in increased activity of NR1I2 protein]; bisphenol AF inhibits the reaction [Rifaximin results in increased activity of NR1I2 protein]; bisphenol AF metabolite inhibits the reaction [Rifaximin results in increased activity of NR1I2 protein]; Rifaximin binds to and results in increased activity of NR1I2 protein
[Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL3 protein]; [Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]; [Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]; [Rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
rifaximin results in increased expression of NR1I2 mRNA
NR1I2 results in increased susceptibility to rifaximin 		CTD PMID:21599020 PMID:22291955 PMID:22790967 PMID:27506419 PMID:30408883 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of PPARG mRNA CTD PMID:22790967 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [rifaximin co-treated with Trinitrobenzenesulfonic Acid] results in increased expression of TGFB1 protein CTD PMID:21599020 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [rifaximin binds to and results in increased activity of NR1I2 protein] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; rifaximin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] CTD PMID:21599020 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
sulfasalazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase increases expression ISO Sulfasalazine results in increased expression of AADAT mRNA CTD PMID:22016648 NCBI chr16:34,520,236...34,566,388
Ensembl chr16:34,520,238...34,566,540 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium CTD PMID:19853032 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases transport
increases activity
affects transport
decreases methylation
multiple interactions 		ISO ABCG2 protein results in increased transport of Sulfasalazine
Sulfasalazine results in increased activity of ABCG2 protein
ABCG2 gene polymorphism affects the transport of Sulfasalazine
Sulfasalazine results in decreased methylation of ABCG2 promoter
[Sulfasalazine results in decreased methylation of ABCG2 promoter] which results in increased expression of ABCG2 mRNA; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Sulfasalazine promotes the reaction [Cholesterol results in increased activity of ABCG2 protein]; yu ping feng san inhibits the reaction [Sulfasalazine results in increased activity of ABCG2 protein] 		CTD PMID:18167504 PMID:18408567 PMID:20019844 PMID:27475308 PMID:30083819 More... NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression ISO Sulfasalazine results in increased expression of ACAA1B mRNA CTD PMID:31830553 NCBI chr 8:127,750,771...127,759,589
Ensembl chr 8:127,750,743...127,759,569 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Sulfasalazine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO Sulfasalazine results in increased expression of ACOT1 mRNA CTD PMID:31830553 NCBI chr 6:109,367,274...109,375,268
Ensembl chr 6:109,367,268...109,380,749 		JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression ISO Sulfasalazine results in increased expression of ACOT3 mRNA CTD PMID:31830553 NCBI chr 6:109,413,617...109,419,840
Ensembl chr 6:109,413,534...109,421,427
Ensembl chr 6:109,413,534...109,421,427 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO Sulfasalazine results in increased expression of ACOX1 mRNA CTD PMID:31830553 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:15633128 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adrm1 ADRM1 26S proteasome ubiquitin receptor increases expression EXP Sulfasalazine results in increased expression of ADRM1 protein CTD PMID:15928459 NCBI chr 3:187,643,043...187,647,805
Ensembl chr 3:187,642,654...187,648,483 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
affects localization 		ISO BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein] CTD PMID:12381674 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of AKT1 protein] CTD PMID:36806191 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
increases expression 		ISO
EXP 		Sulfasalazine results in decreased expression of ALDH1A1 mRNA
Sulfasalazine results in increased expression of ALDH1A1 protein 		CTD PMID:15928459 PMID:31830553 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases expression EXP Sulfasalazine results in increased expression of ALDH2 protein CTD PMID:15928459 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 decreases expression EXP Sulfasalazine results in decreased expression of ALDH6A1 protein CTD PMID:15928459 NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:109,809,122...109,829,743 		JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of ALPI protein] CTD PMID:15867298 NCBI chr 9:95,221,314...95,224,780
Ensembl chr 9:95,221,314...95,224,780 		JBrowse link
G Anxa2 annexin A2 increases expression ISO Sulfasalazine results in increased expression of ANXA2 mRNA CTD PMID:22016648 NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression ISO Sulfasalazine results in decreased expression of APOA4 mRNA CTD PMID:31830553 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression EXP Sulfasalazine results in increased expression of ATP5F1A protein CTD PMID:15928459 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922 		JBrowse link
G Azin1 antizyme inhibitor 1 increases expression ISO Sulfasalazine results in increased expression of AZIN1 mRNA CTD PMID:22016648 NCBI chr 7:71,539,711...71,566,515
Ensembl chr 7:71,539,711...71,566,515 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
multiple interactions 		ISO
EXP 		Sulfasalazine affects the localization of BAX protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein] 		CTD PMID:12381674 PMID:31428839 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP 		BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon 		CTD
RGD		 PMID:12381674 PMID:31428839 PMID:29572553 RGD:152995414 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G C6 complement C6 decreases expression ISO Sulfasalazine results in decreased expression of C6 mRNA CTD PMID:31830553 NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:55,573,653...55,649,120 		JBrowse link
G Calr calreticulin decreases expression EXP Sulfasalazine results in decreased expression of CALR protein CTD PMID:15928459 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP
ISO 		Sulfasalazine inhibits the reaction [Acetic Acid results in increased cleavage of CASP1 protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP1 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein] 		CTD PMID:30408459 PMID:35595039 PMID:36577154 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity 		ISO
EXP 		Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]; Sulfasalazine results in increased cleavage of and results in increased activity of CASP3 protein
Sulfasalazine results in increased activity of CASP3 protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein] 		CTD PMID:12381674 PMID:16322111 PMID:17051331 PMID:19473188 PMID:19859796 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage 		ISO Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP9 protein]
Sulfasalazine results in increased cleavage of CASP9 protein 		CTD PMID:16322111 PMID:19859796 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase increases activity
multiple interactions
decreases activity 		EXP
ISO 		Sulfasalazine results in increased activity of CAT protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]
Sulfasalazine results in decreased activity of CAT protein 		CTD PMID:19028562 PMID:19071188 PMID:28421826 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA CTD PMID:19015640 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740 		JBrowse link
G Cbr1 carbonyl reductase 1 decreases expression EXP Sulfasalazine results in decreased expression of CBR1 protein CTD PMID:15928459 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL2 mRNA] CTD PMID:17449585 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression 		ISO
EXP 		[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA
Sulfasalazine results in decreased expression of CCND1 mRNA 		CTD PMID:17202759 PMID:19015640 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO Sulfasalazine results in increased expression of CCNG1 mRNA CTD PMID:22016648 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA CTD PMID:28863153 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cd19 CD19 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA CTD PMID:28863153 NCBI chr 1:190,417,853...190,424,494
Ensembl chr 1:190,417,853...190,424,355 		JBrowse link
G Cd27 CD27 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA CTD PMID:28863153 NCBI chr 4:159,716,932...159,721,823
Ensembl chr 4:159,716,935...159,721,823 		JBrowse link
G Cd38 CD38 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA CTD PMID:28863153 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505 		JBrowse link
G Cd3d CD3 delta subunit of T-cell receptor complex multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA CTD PMID:28863153 NCBI chr 8:54,184,573...54,190,112
Ensembl chr 8:54,175,155...54,196,722 		JBrowse link
G Cd46 CD46 molecule decreases expression EXP Sulfasalazine results in decreased expression of CD46 mRNA CTD PMID:15625186 NCBI chr13:109,104,122...109,134,903 JBrowse link
G Cd55 CD55 molecule (Cromer blood group) decreases expression EXP Sulfasalazine results in decreased expression of CD55 mRNA CTD PMID:15625186 PMID:17166698 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:44,409,587...44,438,107 		JBrowse link
G Cd59b CD59b molecule decreases expression EXP Sulfasalazine results in decreased expression of CD59 mRNA; Sulfasalazine results in decreased expression of CD59 protein CTD PMID:15625186 PMID:17166698 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:110,914,091...110,935,310 		JBrowse link
G Cd74 CD74 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA CTD PMID:28863153 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA CTD PMID:19015640 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression 		EXP protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein] CTD PMID:19234301 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cldn2 claudin 2 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 protein] CTD PMID:35290143 NCBI chr  X:108,248,383...108,258,847
Ensembl chr  X:108,237,676...108,262,377 		JBrowse link
G Clu clusterin increases expression ISO Sulfasalazine results in increased expression of CLU mRNA CTD PMID:22016648 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein] CTD PMID:15633128 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein] CTD PMID:17051331 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA CTD PMID:28863153 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:69,813,265...69,819,973 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO
EXP 		[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 protein] 		CTD PMID:19015640 PMID:26165751 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
affects secretion 		ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein] CTD PMID:12231210 PMID:28863153 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects secretion
multiple interactions 		ISO Sulfasalazine affects the secretion of CXCL1 protein
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein] 		CTD PMID:12231210 PMID:28863153 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Sulfasalazine results in increased expression of CYP1A1 mRNA CTD PMID:17202759 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 decreases expression ISO Sulfasalazine results in decreased expression of CYP27B1 mRNA CTD PMID:15243130 NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:64,756,626...64,761,570 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Sulfasalazine results in increased expression of CYP2B10 mRNA CTD PMID:31830553 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases expression ISO Sulfasalazine results in increased expression of CYP2C55 mRNA; Sulfasalazine results in increased expression of CYP2C55 protein CTD PMID:31830553 NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:246,286,341...246,348,607 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression ISO Sulfasalazine results in increased expression of CYP2C29 mRNA CTD PMID:31830553 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Sulfasalazine results in increased expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA] CTD PMID:16614379 NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO
EXP 		Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA] 		CTD PMID:16728495 PMID:21068073 NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594 		JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 increases expression ISO Sulfasalazine results in increased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr19:37,671,019...37,689,163
Ensembl chr19:37,670,945...37,690,120 		JBrowse link
G Egf epidermal growth factor increases expression ISO Sulfasalazine results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression 		ISO [Sulfasalazine co-treated with celastrol] affects the expression of EGFR protein; [Sulfasalazine co-treated with celastrol] results in decreased expression of EGFR protein; geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
Sulfasalazine results in decreased expression of EGFR mRNA; Sulfasalazine results in decreased expression of EGFR protein 		CTD PMID:20007406 PMID:31830553 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Egr1 early growth response 1 decreases expression ISO Sulfasalazine results in decreased expression of EGR1 mRNA CTD PMID:31830553 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO Sulfasalazine results in increased expression of EPHX1 mRNA CTD PMID:22016648 PMID:31830553 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Sulfasalazine results in increased expression of FABP4 mRNA CTD PMID:22016648 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fga fibrinogen alpha chain increases expression ISO Sulfasalazine results in increased expression of FGA mRNA CTD PMID:22016648 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577 		JBrowse link
G Fh fumarate hydratase decreases expression EXP Sulfasalazine results in decreased expression of FH protein CTD PMID:15928459 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627 		JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 decreases expression ISO Sulfasalazine results in decreased expression of FMC1 mRNA CTD PMID:31830553 NCBI chr 4:68,241,009...68,249,045
Ensembl chr 4:68,241,009...68,268,534 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein] CTD PMID:28421826 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Sulfasalazine results in increased expression of FTL1 mRNA CTD PMID:22016648 NCBI chr 1:105,072,858...105,074,705
Ensembl chr  X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915 		JBrowse link
G G0s2 G0/G1switch 2 increases expression ISO Sulfasalazine results in increased expression of G0S2 mRNA CTD PMID:31830553 NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression EXP Sulfasalazine results in decreased expression of GADD45B mRNA CTD PMID:15633128 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP Sulfasalazine results in decreased expression of GAPDH protein CTD PMID:15928459 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein] CTD PMID:14687604 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Sulfasalazine results in increased expression of GPT protein CTD PMID:31830553 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO Sulfasalazine results in decreased expression of GPX3 mRNA CTD PMID:31830553 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein] CTD PMID:26165751 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Sulfasalazine results in decreased activity of GSR protein CTD PMID:19028562 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO Sulfasalazine results in increased expression of GSTA1 mRNA CTD PMID:31830553 NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Sulfasalazine results in increased expression of GSTA5 mRNA CTD PMID:17202759 NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP Sulfasalazine results in decreased expression of GSTM1 protein CTD PMID:15928459 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Sulfasalazine results in increased expression of GSTM2 mRNA CTD PMID:31830553 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Sulfasalazine results in increased expression of GSTM3 mRNA CTD PMID:31830553 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP Sulfasalazine results in decreased expression of GSTP1 mRNA CTD PMID:16141653 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA] CTD PMID:12745093 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity 		ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]
Sulfasalazine results in increased activity of HIF1A protein 		CTD PMID:12808024 PMID:19502547 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Sulfasalazine results in increased expression of HINT1 mRNA CTD PMID:22016648 NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:93,430,926...93,431,642
Ensembl chr10:93,430,926...93,431,642 		JBrowse link
G Hmgb1 high mobility group box 1 increases expression
multiple interactions 		EXP Sulfasalazine results in increased expression of HMGB1 mRNA
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon 		CTD
RGD		 PMID:16141653 PMID:29572553 RGD:152995414 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
multiple interactions
increases expression 		EXP HMOX1 protein results in increased susceptibility to Sulfasalazine
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]
[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein; Sulfasalazine results in increased expression of HMOX1 mRNA; Sulfasalazine results in increased expression of HMOX1 protein 		CTD PMID:19234301 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression EXP Sulfasalazine results in decreased expression of HSD17B3 mRNA CTD PMID:29197623 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO Sulfasalazine results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Sulfasalazine results in decreased expression of HSD3B1 mRNA CTD PMID:29197623 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO Sulfasalazine results in increased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Sulfasalazine results in increased expression of HSPA1A mRNA CTD PMID:22016648 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression EXP Sulfasalazine results in decreased expression of HSPA1B mRNA CTD PMID:16141653 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression EXP Sulfasalazine results in decreased expression of HSPA2 protein CTD PMID:15928459 NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
increases expression
multiple interactions 		ISO
EXP 		Sulfasalazine results in decreased expression of ICAM1 mRNA; Sulfasalazine results in decreased expression of ICAM1 protein
Sulfasalazine results in increased expression of ICAM1 protein
Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon 		CTD
RGD		 PMID:11264155 PMID:15553846 PMID:17259377 PMID:20823682 PMID:26165751 More... RGD:152995414 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta increases expression ISO Sulfasalazine results in increased expression of IDH3B mRNA CTD PMID:22016648 NCBI chr 3:137,934,971...137,940,275
Ensembl chr 3:137,934,697...137,940,107 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IDO1 mRNA] CTD PMID:20884048 NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased expression of CXCL8 protein]
Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein] 		CTD PMID:11529938 PMID:15269287 PMID:17051331 PMID:25231984 PMID:29594315 More... NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression EXP Sulfasalazine affects the expression of IGFBP3 mRNA CTD PMID:16141653 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO Sulfasalazine results in decreased expression of IKBKB protein CTD PMID:15564333 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP 		Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]; Sulfasalazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon 		CTD
RGD		 PMID:15604057 PMID:17051331 PMID:25231984 PMID:25727887 PMID:29731490 More... RGD:152995414 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA CTD PMID:28863153 NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:54,459,882...54,475,028 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]] CTD PMID:11529938 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP
ISO 		Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL18 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein] 		CTD PMID:35595039 PMID:36577154 PMID:38764152 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression 		ISO
EXP 		[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL8 protein]; Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of IL1B mRNA
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein] 		CTD PMID:12133438 PMID:12231210 PMID:15604057 PMID:15793857 PMID:15867298 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA] CTD PMID:17449585 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA] CTD PMID:15867298 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL2 protein] 		CTD PMID:17051331 PMID:29594315 PMID:32272095 PMID:35362542 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein] CTD PMID:7815356 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein] CTD PMID:25729217 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP 		Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] 		CTD PMID:12135912 PMID:17051331 PMID:19956958 PMID:20884048 PMID:21070844 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Insr insulin receptor increases expression ISO Sulfasalazine results in increased expression of INSR protein CTD PMID:15564333 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803 		JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA CTD PMID:28863153 NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,930,471...33,948,730 		JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression ISO Sulfasalazine results in decreased expression of IRS2 mRNA CTD PMID:31830553 NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein] CTD PMID:8094364 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein] CTD PMID:8094364 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182 		JBrowse link
G Itk IL2-inducible T-cell kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA CTD PMID:28863153 NCBI chr10:31,254,667...31,316,004
Ensembl chr10:31,254,667...31,316,004 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of JAK2 protein] CTD PMID:32272095 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Jchain joining chain of multimeric IgA and IgM multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA CTD PMID:28863153 NCBI chr14:19,822,976...19,831,072
Ensembl chr14:19,822,976...19,838,307 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA CTD PMID:28863153 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267 		JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions
increases activity 		ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein]
Sulfasalazine results in increased activity of LDHC protein 		CTD PMID:28421826 NCBI chr 1:106,522,140...106,539,649
Ensembl chr 1:106,522,236...106,542,802 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein] CTD PMID:28421826 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445 		JBrowse link
G Lsm10 LSM10, U7 small nuclear RNA associated decreases expression ISO Sulfasalazine results in decreased expression of LSM10 mRNA CTD PMID:31830553 NCBI chr 5:143,649,817...143,660,391
Ensembl chr 5:143,615,360...143,663,986 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO 		Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK1 protein] CTD PMID:36806191 PMID:38764152 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO 		Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK3 protein] CTD PMID:36806191 PMID:38764152 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP Sulfasalazine results in increased phosphorylation of MAPK9 protein CTD PMID:15633128 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mill1 MHC I like leukocyte 1 decreases expression ISO Sulfasalazine results in decreased expression of MICA mRNA; Sulfasalazine results in decreased expression of MICA protein CTD PMID:15494508 NCBI chr 1:87,500,591...87,526,983
Ensembl chr 1:87,500,676...87,526,981 		JBrowse link
G Mir223 microRNA 223 multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in decreased expression of MIR223 mRNA] CTD PMID:35595039 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:65,151,383...65,151,492 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA CTD PMID:28863153 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Sulfasalazine promotes the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein] CTD PMID:15633128 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP 		Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of MMP9 protein] 		CTD PMID:12745093 PMID:22119283 PMID:30972795 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity 		EXP
ISO 		Sulfasalazine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
Sulfasalazine results in decreased activity of MPO protein 		CTD
RGD		 PMID:17373747 PMID:20380826 PMID:22119283 PMID:23665423 PMID:25231984 More... RGD:152995414 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Sulfasalazine affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502 		JBrowse link
G Ms4a1 membrane spanning 4-domains A1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA CTD PMID:28863153 NCBI chr 1:217,331,274...217,351,934
Ensembl chr 1:217,331,274...217,343,447 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases response to substance ISO MTHFR gene polymorphism results in increased susceptibility to Sulfasalazine; MTHFR protein results in increased susceptibility to Sulfasalazine CTD PMID:19578646 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105 		JBrowse link
G Muc17 mucin 17, cell surface associated multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC17 mRNA] CTD PMID:17449585 NCBI chr12:25,139,076...25,175,249 JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA] CTD PMID:17449585 NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:206,229,035...206,261,280 		JBrowse link
G Muc4 mucin 4, cell surface associated multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA] CTD PMID:17449585 NCBI chr11:81,513,321...81,575,200 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP
ISO 		Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of MYD88 protein] 		CTD PMID:35290143 PMID:35362542 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nat2 N-acetyltransferase 2 affects metabolic processing
affects response to substance
increases metabolic processing
increases acetylation 		ISO NAT2 gene polymorphism affects the metabolism of Sulfasalazine; NAT2 protein affects the metabolism of Sulfasalazine; NAT2 protein polymorphism affects the metabolism of Sulfasalazine
NAT2 protein affects the susceptibility to Sulfasalazine
NAT2 protein results in increased metabolism of Sulfasalazine
NAT2 protein results in increased acetylation of Sulfasalazine 		CTD PMID:12465141 PMID:15032315 PMID:17377643 PMID:17502830 PMID:19560446 NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304 		JBrowse link
G Ncl nucleolin decreases expression EXP Sulfasalazine results in decreased expression of NCL protein CTD PMID:15928459 NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:94,446,682...94,456,083 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP 		[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein; Acetylcysteine inhibits the reaction [[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein]
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter] 		CTD PMID:19234301 PMID:31428839 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression
decreases localization 		ISO
EXP 		Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Sulfasalazine results in decreased expression of NFKB1 protein
Sulfasalazine results in decreased localization of NFKB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NFKB1 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKB1 protein] 		CTD PMID:9486988 PMID:12135912 PMID:15269287 PMID:17259377 PMID:26165751 More... NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
decreases phosphorylation
increases degradation 		ISO
EXP 		Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Sulfasalazine results in decreased expression of NFKBIA protein
Sulfasalazine results in decreased phosphorylation of NFKBIA protein
Sulfasalazine results in increased degradation of NFKBIA protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein] 		CTD PMID:9486988 PMID:11786414 PMID:15494508 PMID:15793857 PMID:16934226 More... NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP
ISO 		Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 mRNA]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein] 		CTD PMID:30408459 PMID:35595039 PMID:36577154 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression 		ISO
EXP 		Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Sulfasalazine affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]
Sulfasalazine results in decreased expression of NOS2 mRNA 		CTD PMID:11529938 PMID:15867298 PMID:16925772 PMID:16934226 PMID:17259377 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP
ISO 		Sulfasalazine results in increased expression of NQO1 mRNA CTD PMID:19234301 PMID:22016648 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO Sulfasalazine results in increased expression of NR3C1 mRNA; Sulfasalazine results in increased expression of NR3C1 protein CTD PMID:17267514 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Nsfl1c NSFL1 cofactor increases expression EXP Sulfasalazine results in increased expression of NSFL1C protein CTD PMID:15928459 NCBI chr 3:160,438,708...160,463,261
Ensembl chr 3:160,438,708...160,463,228 		JBrowse link
G Oat ornithine aminotransferase increases expression ISO Sulfasalazine results in increased expression of OAT mRNA CTD PMID:22016648 NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754 		JBrowse link
G Ocln occludin multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein] CTD PMID:35290143 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO Sulfasalazine results in increased expression of ODC1 mRNA CTD PMID:22016648 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA] CTD PMID:11901219 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Sulfasalazine results in increased expression of PCNA mRNA CTD PMID:22016648 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 decreases expression EXP Sulfasalazine results in decreased expression of PEBP1 protein CTD PMID:15928459 NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780 		JBrowse link
G Pgam2 phosphoglycerate mutase 2 increases expression ISO Sulfasalazine results in increased expression of PGAM2 mRNA CTD PMID:22016648 NCBI chr14:84,895,763...84,897,874
Ensembl chr14:84,895,744...84,897,894 		JBrowse link
G Pla2g1b phospholipase A2 group IB multiple interactions ISO Sulfasalazine inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein] CTD PMID:15528384 NCBI chr12:46,802,932...46,814,511
Ensembl chr12:46,802,939...46,813,693 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions 		EXP
ISO 		Sulfasalazine results in increased expression of PPARG mRNA
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein] 		CTD PMID:19365232 PMID:26165751 PMID:31830553 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA CTD PMID:28863153 NCBI chr20:49,542,465...49,564,088
Ensembl chr20:49,542,465...49,564,088 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP
ISO 		Sulfasalazine results in increased expression of PRDX1 mRNA CTD PMID:16141653 PMID:22016648 NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504 		JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Sulfasalazine results in increased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300 		JBrowse link
G Psma7 proteasome 20S subunit alpha 7 decreases expression EXP Sulfasalazine results in decreased expression of PSMA7 protein CTD PMID:15928459 NCBI chr 3:187,514,901...187,521,289
Ensembl chr 3:187,513,441...187,521,253 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression EXP Sulfasalazine results in decreased expression of PSMB9 mRNA CTD PMID:17202759 NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,668,739...4,674,421 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions 		EXP
ISO 		Sulfasalazine results in decreased expression of PTGS2 mRNA
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein] 		CTD PMID:17259377 PMID:19956958 PMID:25576893 PMID:29187079 PMID:30408459 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 increases expression ISO Sulfasalazine results in increased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr 3:97,345,752...97,355,396
Ensembl chr 3:97,345,752...97,355,254 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA CTD PMID:28863153 NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:124,622,313...124,684,434 		JBrowse link
G Rbp4 retinol binding protein 4 affects expression ISO Sulfasalazine affects the expression of RBP4 mRNA CTD PMID:22016648 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:245,306,349...245,313,898 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization
affects localization
increases localization
decreases activity 		ISO
EXP 		Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine results in decreased expression of and results in decreased activity of RELA protein; Sulfasalazine results in decreased phosphorylation of and results in decreased activity of RELA protein
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon
Sulfasalazine results in decreased localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine affects the localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine results in increased localization of RELA protein
Sulfasalazine results in decreased activity of RELA protein 		CTD
RGD		 PMID:9486988 PMID:12135912 PMID:14687604 PMID:15269287 PMID:15564333 More... RGD:152995414 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Sulfasalazine results in increased expression of RGS16 mRNA CTD PMID:31830553 NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA] CTD PMID:19693652 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663 		JBrowse link
G Rnf186 ring finger protein 186 decreases expression ISO Sulfasalazine results in decreased expression of RNF186 mRNA CTD PMID:31830553 NCBI chr 5:156,493,750...156,494,974
Ensembl chr 5:156,493,752...156,494,978 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression EXP Sulfasalazine affects the expression of RT1-BB mRNA CTD PMID:17202759 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of S100A9 protein] CTD PMID:35362542 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870 		JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA CTD PMID:28863153 NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:37,297,010...37,304,500 		JBrowse link
G Sele selectin E increases expression ISO Sulfasalazine results in increased expression of SELE protein CTD PMID:11264155 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Serpina4 serpin family A member 4 decreases expression ISO Sulfasalazine results in decreased expression of SERPINA4-PS1 mRNA CTD PMID:31830553 NCBI chr 6:128,764,738...128,773,858
Ensembl chr 6:128,764,769...128,776,028 		JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Sulfasalazine results in increased expression of SERPINC1 mRNA CTD PMID:22016648 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:75,790,546...75,817,643 		JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression ISO Sulfasalazine results in decreased expression of SIK1 mRNA CTD PMID:31830553 NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698 		JBrowse link
G Slamf7 SLAM family member 7 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA CTD PMID:28863153 NCBI chr13:86,668,060...86,688,222
Ensembl chr13:86,668,060...86,686,341 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO Sulfasalazine results in decreased expression of SLC22A7 mRNA CTD PMID:31830553 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681 		JBrowse link
G Slc25a24 solute carrier family 25 member 24 decreases expression ISO Sulfasalazine results in decreased expression of SLC25A24 mRNA CTD PMID:31830553 NCBI chr 2:199,449,425...199,487,287
Ensembl chr 2:199,449,345...199,487,290 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 increases expression ISO Sulfasalazine results in increased expression of SLC25A6 mRNA CTD PMID:22016648 NCBI chr  X:120,897,616...120,900,683
Ensembl chr  X:120,897,563...120,900,688 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression ISO Sulfasalazine results in decreased expression of SLC30A1 mRNA CTD PMID:31830553 NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine] CTD PMID:19576933 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity 		ISO
EXP 		Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Methotrexate]
Sulfasalazine results in decreased activity of SLC46A1 protein
Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid] 		CTD PMID:17475902 PMID:18174275 PMID:19762432 NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,859,504...63,866,869 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases activity
multiple interactions 		ISO Sulfasalazine results in decreased activity of SLC7A11 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine] 		CTD PMID:19015640 PMID:19576933 PMID:20007406 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 decreases expression ISO Sulfasalazine results in decreased expression of SOCS2 mRNA CTD PMID:31830553 NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:31,874,463...31,930,423 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Sulfasalazine results in increased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO Sulfasalazine results in decreased expression of SOD3 mRNA CTD PMID:31830553 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Sulfasalazine results in increased expression of SPP1 mRNA CTD PMID:22016648 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 increases expression EXP Sulfasalazine results in increased expression of SRSF5 protein CTD PMID:15928459 NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
affects expression 		EXP Sulfasalazine results in decreased expression of STAR protein
Sulfasalazine affects the expression of STAR mRNA 		CTD PMID:29197623 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of STAT3 protein] CTD PMID:32272095 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions
decreases activity 		ISO [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2 CTD PMID:2572437 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA] CTD PMID:20884048 NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586 		JBrowse link
G Tff3 trefoil factor 3 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA] CTD PMID:17449585 NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,194,626...9,199,333 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
decreases expression 		ISO [Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of THRA mRNA; Sulfasalazine results in decreased expression of THRA mRNA alternative form 		CTD PMID:17641275 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA] CTD PMID:16614379 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:15633128 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Sulfasalazine results in increased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO Sulfasalazine results in increased expression of TIMP3 mRNA CTD PMID:22016648 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein] CTD PMID:35290143 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:12888452 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein] CTD PMID:19956958 PMID:32272095 PMID:35362542 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR9 protein] CTD PMID:35290143 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:115,742,889...115,750,148 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance
decreases expression
decreases secretion 		ISO
EXP 		[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine promotes the reaction [Ganciclovir results in increased secretion of TNF protein]
Sulfasalazine results in increased susceptibility to TNF protein
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine binds to and results in decreased activity of TNF protein; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased secretion of TNF protein]
Sulfasalazine results in decreased expression of TNF mRNA
Sulfasalazine results in decreased secretion of TNF protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon 		CTD
RGD		 PMID:8094364 PMID:8598465 PMID:9486988 PMID:11901219 PMID:12135912 More... RGD:152995414 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases secretion ISO Sulfasalazine results in increased secretion of TNFRSF11B protein CTD PMID:15593184 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075 		JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA CTD PMID:28863153 NCBI chr10:4,808,023...4,813,857 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNFRSF1A protein] CTD PMID:35595039 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Sulfasalazine results in decreased expression of TNFSF11 mRNA; Sulfasalazine results in decreased expression of TNFSF11 protein CTD PMID:15593184 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Tpm3 tropomyosin 3 decreases expression ISO Sulfasalazine results in decreased expression of TPM3 mRNA alternative form; Sulfasalazine results in decreased expression of TPM3 protein alternative form CTD PMID:19369484 NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TRAF6 protein] CTD PMID:32272095 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases secretion ISO Sulfasalazine results in increased secretion of TSHB protein CTD PMID:12587019 NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984 		JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO Sulfasalazine results in increased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726 		JBrowse link
G Tymp thymidine phosphorylase multiple interactions
decreases expression 		ISO Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine results in decreased expression of and results in decreased activity of TYMP protein
Sulfasalazine results in decreased expression of TYMP mRNA 		CTD PMID:15269287 NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:122,316,520...122,324,003 		JBrowse link
G Ubc ubiquitin C increases expression ISO Sulfasalazine results in increased expression of UBC mRNA CTD PMID:22016648 NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
increases expression 		ISO
EXP 		Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
Sulfasalazine results in decreased expression of VCAM1 mRNA; Sulfasalazine results in decreased expression of VCAM1 protein
Sulfasalazine results in increased expression of VCAM1 protein 		CTD PMID:11264155 PMID:15553846 PMID:17259377 PMID:19693652 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vim vimentin increases expression ISO Sulfasalazine results in increased expression of VIM mRNA CTD PMID:22016648 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA CTD PMID:28863153 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
tectochrysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases response to substance
decreases activity 		ISO [tectochrysin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
ABCB1 protein results in decreased susceptibility to tectochrysin 		CTD PMID:37259354 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO tectochrysin results in decreased activity of ABCG2 protein CTD PMID:15930306 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
tegaserod term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO tegaserod results in decreased activity of CYP1A2 protein CTD PMID:11560869 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
multiple interactions 		ISO CYP2D6 protein results in increased metabolism of tegaserod
tegaserod results in decreased activity of CYP2D6 protein
Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod] 		CTD PMID:11560869 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO tegaserod binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions ISO tegaserod binds to and results in increased activity of HTR4 protein CTD PMID:15238200 PMID:15961989 NCBI chr18:58,036,277...58,221,327
Ensembl chr18:58,036,277...58,219,622 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO tegaserod binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO tegaserod binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20871
    role 20829
      application 20632
        pharmaceutical 20427
          drug 20427
            gastrointestinal drug 383
              16,16-dimethylprostaglandin E2 8
              3,7,12-trioxo-5beta-cholanic acid 1
              alosetron + 0
              alpha-methylene gamma-butyrolactone + 0
              antidiarrhoeal drug + 46
              auraptene 24
              balsalazide + 1
              balsalazide disodium 0
              betazole + 0
              betazole dihydrochloride 0
              ceruletide + 74
              ceruletide diethylamine 0
              cisapride 11
              cyproheptadine + 14
              cyproheptadine hydrochloride sesquihydrate 0
              devazepide 6
              eluxadoline 1
              lactulose 28
              metoclopramide 31
              metoclopramide dihydrochloride monohydrate 0
              metoclopramide hydrochloride + 0
              mosapride 0
              proglumide + 0
              rifaximin 22
              sofalcone 0
              sulfasalazine 227
              tegaserod + 6
paths to the root