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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gossypin
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Accession:CHEBI:5525 term browser browse the term
Definition:A glycosyloxyflavone that is gossypetin attached to a β-D-glucopyranosyl residue at position 8 via a glycosidic linkage.
Synonyms:related_synonym: 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-oxo-4H-1-benzopyran-8-yl beta-D-glucopyranoside;   3,5,7,8,3',4'-Hexahydroxyflavone-8-glucoside;   Gossypetin 8-O-glucoside
 xref: CAS:652-78-8;   KNApSAcK:C00005690
 xref_mesh: MESH:C022944
 xref: Reaxys:71526;   kegg.compound:C10051;   lincs.smallmolecule:LSM-36969;   pubmed:23543365;   pubmed:23738444;   pubmed:24347764
 chemrof_formula: C21H20O13
 chemrof_inchi: InChI=1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13-,15+,17-,21+/m1/s1
 chemrof_smiles: O=c1c(O)c(-c2ccc(O)c(O)c2)oc2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(O)cc(O)c12
 chemrof_inchikey: SJRXVLUZMMDCNG-KKPQBLLMSA-N
 cyclic_relationship: has_functional_parent CHEBI:16400


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gossypin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf1 activating transcription factor 1 multiple interactions
decreases phosphorylation 		ISO gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein]
gossypin results in decreased phosphorylation of ATF1 protein 		CTD PMID:30536456 NCBI chr 7:133,240,774...133,283,488
Ensembl chr 7:133,241,197...133,283,485 		JBrowse link
G Aurka aurora kinase A multiple interactions ISO gossypin binds to and results in decreased activity of AURKA protein CTD PMID:30536456 NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:181,546,742...181,562,771 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO gossypin results in decreased expression of BCL2L1 protein CTD PMID:30536456 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO gossypin results in increased cleavage of CASP3 protein CTD PMID:30536456 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO gossypin results in increased cleavage of CASP7 protein CTD PMID:30536456 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO gossypin results in increased cleavage of CASP9 protein CTD PMID:30536456 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]; gossypin inhibits the reaction [Oleic Acid results in increased activity of CAT protein] CTD PMID:37148149 PMID:37696682 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO gossypin results in decreased expression of CCNA2 protein CTD PMID:30536456 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO gossypin results in decreased expression of CCNB1 protein CTD PMID:30536456 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation ISO gossypin results in decreased phosphorylation of CDK1 protein CTD PMID:30536456 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Crp C-reactive protein multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein] CTD PMID:37148149 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO gossypin inhibits the reaction [EGF protein results in increased phosphorylation of ATF1 protein] CTD PMID:30536456 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein] CTD PMID:37148149 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL10 protein] CTD PMID:37148149 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il13 interleukin 13 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL13 protein] CTD PMID:37148149 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL17A protein] CTD PMID:37148149 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL18 protein] CTD PMID:37148149 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL1B mRNA] CTD PMID:37148149 PMID:37696682 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 protein] CTD PMID:37148149 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL5 protein] CTD PMID:37148149 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA] CTD PMID:37148149 PMID:37696682 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation ISO gossypin results in decreased phosphorylation of JUN protein CTD PMID:30536456 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:37148149 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein] CTD PMID:37148149 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO gossypin results in increased cleavage of PARP1 protein CTD PMID:30536456 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:37148149 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 multiple interactions ISO gossypin binds to and results in decreased activity of RPS6KA3 protein CTD PMID:30536456 NCBI chr  X:39,325,926...39,432,017
Ensembl chr  X:39,325,926...39,433,678 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein] CTD PMID:37148149 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF mRNA]; gossypin inhibits the reaction [Oleic Acid results in increased expression of TNF protein] CTD PMID:37148149 PMID:37696682 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
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  CHEBI ontology 20874
    role 20844
      application 20572
        pharmaceutical 20359
          drug 20359
            protective agent 18433
              neuroprotective agent 15811
                gossypin 29
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  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbohydrates and carbohydrate derivatives 15263
                                    carbohydrate derivative 14522
                                      glycosyl compound 13128
                                        glycoside 12247
                                          glycosyloxyflavone 643
                                            gossypin 29
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