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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gonadorelin
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Accession:CHEBI:5520 term browser browse the term
Definition:A ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence.
Synonyms:related_synonym: 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide;   5-oxo-PHWSYGLRPGNH2;   Follicle-stimulating hormone-releasing factor;   GnRH-I;   Gonadoliberin I;   Gonadotropin-releasing factor;   Gonadotropin-releasing hormone I;   LH-Releasing factor;   LH-Releasing hormone;   Luteinizing hormone-releasing factor;   gonadorelina;   gonadorelinum;   luliberin;   p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
 xref: CAS:33515-09-2;   DrugBank:DB00644
 xref_mesh: MESH:D007987
 xref: Reaxys:741807;   drugcentral:2958;   kegg.compound:C07607;   kegg.drug:D08027;   pubmed:21872303;   pubmed:22112812;   pubmed:22214466;   pubmed:22289217;   pubmed:22504307;   pubmed:22761896;   wikipedia.en:Gonadorelin
 chemrof_formula: C55H75N17O13
 chemrof_smiles: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc2ccccc12)NC(=O)[C@H](Cc1cncn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O
 chemrof_inchi: InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
 chemrof_inchikey: XLXSAKCOAKORKW-AQJXLSMYSA-N


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gonadorelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gonadotropin-Releasing Hormone results in decreased expression of ESR1 protein]; Gonadotropin-Releasing Hormone results in increased ubiquitination of and results in increased degradation of and results in decreased expression of ESR1 protein CTD PMID:16055746 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 increases expression ISO Gonadotropin-Releasing Hormone results in increased expression of UBE2D2 mRNA; Gonadotropin-Releasing Hormone results in increased expression of UBE2D2 protein CTD PMID:16055746 NCBI chr18:27,638,399...27,680,386
Ensembl chr18:27,638,527...27,683,074 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        molecular messenger 19151
          hormone 19098
            peptide hormone 153
              gonadorelin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carboxamide 17697
                                    peptide 11484
                                      oligopeptide 1362
                                        gonadorelin 2
paths to the root