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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:homovanillic acid
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Accession:CHEBI:545959 term browser browse the term
Definition:A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Synonyms:exact_synonym: 2-(4-hydroxy-3-methoxyphenyl)acetic acid
 related_synonym: (4-hydroxy-3-methoxyphenyl)acetic acid;   3-Methoxy-4-hydroxyphenylacetate;   3-Methoxy-4-hydroxyphenylacetic acid;   4-Hydroxy-3-methoxybenzeneacetic acid;   Formula=C9H10O4;   HVA;   InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12);   InChIKey=QRMZSPFSDQBLIX-UHFFFAOYSA-N;   SMILES=COc1cc(CC(O)=O)ccc1O;   Vanillacetic acid
 alt_id: CHEBI:5758
 xref: CAS:306-08-1;   HMDB:HMDB0000118;   KEGG:C05582;   KNApSAcK:C00029504
 xref_mesh: MESH:D006719
 xref: MetaCyc:CPD-7651;   PMID:14688447;   PMID:24007816;   PMID:24416192;   PMID:24423636;   PMID:8353435;   Reaxys:2213447;   Wikipedia:Homovanillic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:133744


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homovanillic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 multiple interactions ISO AQP9 gene mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased abundance of Homovanillic Acid] CTD PMID:29566083 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO
EXP		 [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid CTD PMID:11793163 PMID:15190105 PMID:16012872 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Maob monoamine oxidase B multiple interactions EXP [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid CTD PMID:16012872 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of Homovanillic Acid] CTD PMID:11085313 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases abundance ISO NR3C1 protein results in increased abundance of Homovanillic Acid CTD PMID:11226678 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid] CTD PMID:8884884 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of Homovanillic Acid CTD PMID:10318960 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sct secretin increases abundance ISO SCT protein results in increased abundance of Homovanillic Acid CTD PMID:16168596 NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Homovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Tfam transcription factor A, mitochondrial decreases abundance ISO TFAM gene mutant form results in decreased abundance of Homovanillic Acid CTD PMID:28595911 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Vdr vitamin D receptor multiple interactions
increases abundance		 ISO Calcitriol promotes the reaction [VDR protein results in increased abundance of Homovanillic Acid] CTD PMID:27450565 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        poison 18678
          toxin 16002
            phenylacetic acid 1361
              (3,4-dihydroxyphenyl)acetic acid 20
                homovanillic acid 11
                  N-octylhomovanillamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      hydroxy carboxylic acid 3865
                                        hydroxy monocarboxylic acid 3865
                                          dihydroxy monocarboxylic acid 277
                                            dihydroxyphenylacetic acid 20
                                              (3,4-dihydroxyphenyl)acetic acid 20
                                                homovanillic acid 11
                                                  N-octylhomovanillamide 0
paths to the root