Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:hexamethylene diisocyanate
go back to main search page
Accession:CHEBI:53578 term browser browse the term
Definition:A diisocyanate compound with the two isocyanates linked by a hexane-1,6-diyl group.
Synonyms:related_synonym: 1,6-Diisocyanatohexane;   1,6-Hexamethylene diisocyanate;   1,6-Hexanediol diisocyanate;   1,6-Hexylene diisocyanate;   Formula=C8H12N2O2;   HDI;   HMDI;   Hexane 1,6-diisocyanate;   InChI=1S/C8H12N2O2/c11-7-9-5-3-1-2-4-6-10-8-12/h1-6H2;   InChIKey=RRAMGCGOFNQTLD-UHFFFAOYSA-N;   SMILES=O=C=NCCCCCCN=C=O
 xref: Beilstein:956709;   CAS:822-06-0;   Gmelin:50636
 xref_mesh: MESH:C015262
 xref: PMID:11927838;   PMID:16731584;   PMID:17042142;   PMID:21878336;   PMID:22293954;   PMID:22419182;   PMID:22449630;   PMID:23178851;   PMID:23262421;   PMID:23421488;   PMID:24083673;   PMID:6296214;   Reaxys:956709;   Wikipedia:Hexamethylene_diisocyanate


show annotations for term's descendants           Sort by:
hexamethylene diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887 		JBrowse link
G Aqp10 aquaporin 10 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of AQP10 mRNA CTD PMID:19527780 NCBI chr 2:175,402,609...175,407,677
Ensembl chr 2:175,403,263...175,406,815 		JBrowse link
G Atox1 antioxidant 1 copper chaperone increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATOX1 promoter CTD PMID:25445006 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950 		JBrowse link
G Atp8a2 ATPase phospholipid transporting 8A2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATP8A2 gene CTD PMID:25445006 NCBI chr15:33,817,309...34,350,193
Ensembl chr15:33,819,755...34,350,223 		JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ATP9B gene CTD PMID:25445006 NCBI chr18:74,176,863...74,368,993
Ensembl chr18:74,176,863...74,368,953 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of CACNA1H gene CTD PMID:25445006 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Dhx29 DExH-box helicase 29 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of DHX29 mRNA CTD PMID:19527780 NCBI chr 2:44,560,653...44,611,450
Ensembl chr 2:44,560,714...44,611,445 		JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of DSCAML1 gene CTD PMID:25445006 NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320 		JBrowse link
G Ebag9 estrogen receptor binding site associated antigen 9 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of EBAG9 gene CTD PMID:25445006 NCBI chr 7:75,810,950...75,828,902
Ensembl chr 7:75,810,594...75,861,248 		JBrowse link
G Fam210a family with sequence similarity 210, member A increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FAM210A promoter CTD PMID:25445006 NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171 		JBrowse link
G Farp1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FARP1 gene CTD PMID:25445006 NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299 		JBrowse link
G Fbxw4 F-box and WD repeat domain containing 4 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of FBXW4 gene CTD PMID:25445006 NCBI chr 1:244,426,892...244,514,188
Ensembl chr 1:244,426,896...244,514,163 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of FTH1 mRNA CTD PMID:24211530 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of GCLM mRNA CTD PMID:24211530 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gnrhr gonadotropin releasing hormone receptor affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of GNRHR mRNA CTD PMID:19527780 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance ISO GSTM1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gypc glycophorin C increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of GYPC gene CTD PMID:25445006 NCBI chr18:24,160,738...24,193,408
Ensembl chr18:24,160,739...24,193,204 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of HMOX1 mRNA CTD PMID:24211530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of HSPA6 mRNA CTD PMID:19110044 NCBI chr13:83,273,176...83,274,317 JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of ICAM1 protein CTD PMID:11698162 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of IFNG protein CTD PMID:12884401 PMID:19422874 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of IL10 protein CTD PMID:12884401 PMID:19422874 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 increases secretion ISO 1,6-hexamethylene diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of IL22RA2 gene CTD PMID:25445006 NCBI chr 1:14,353,736...14,377,844
Ensembl chr 1:14,364,489...14,377,844 		JBrowse link
G Il4 interleukin 4 increases expression
increases secretion		 ISO 1,6-hexamethylene diisocyanate results in increased expression of IL4 protein
1,6-hexamethylene diisocyanate results in increased secretion of IL4 protein		 CTD PMID:12884401 PMID:17693426 PMID:19422874 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 increases secretion ISO 1,6-hexamethylene diisocyanate results in increased secretion of IL5 protein CTD PMID:17693426 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ISG20 promoter CTD PMID:25445006 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027 		JBrowse link
G Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ISLR2 gene CTD PMID:25445006 NCBI chr 8:58,608,165...58,616,246
Ensembl chr 8:58,608,709...58,614,650 		JBrowse link
G Kitlg KIT ligand affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of KITLG mRNA CTD PMID:19110044 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Lca5l lebercilin LCA5 like increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of LCA5L gene CTD PMID:25445006 NCBI chr11:35,460,646...35,495,133
Ensembl chr11:35,461,118...35,495,047 		JBrowse link
G Ldha lactate dehydrogenase A affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of LDHA mRNA CTD PMID:19110044 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of LRRN4 gene CTD PMID:25445006 NCBI chr 3:120,138,093...120,150,877
Ensembl chr 3:120,139,410...120,150,831 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 1,6-hexamethylene diisocyanate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK1 protein		 CTD PMID:27129696 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 1,6-hexamethylene diisocyanate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK3 protein		 CTD PMID:27129696 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 ISO 1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK8 protein		 CTD PMID:27129696 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO 1,6-hexamethylene diisocyanate results in increased phosphorylation of MAPK9 protein
1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]		 CTD PMID:27129696 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mrpl58 mitochondrial ribosomal protein L58 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of MRPL58 gene CTD PMID:25445006 NCBI chr10:100,646,374...100,652,871
Ensembl chr10:100,646,216...100,652,871 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of MYC mRNA CTD PMID:24211530 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nab2 Ngfi-A binding protein 2 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of NAB2 gene CTD PMID:25445006 NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989 		JBrowse link
G Nat1 N-acetyltransferase 1 increases response to substance ISO NAT1 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to 1,6-hexamethylene diisocyanate CTD PMID:11927838 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nexn nexilin (F actin binding protein) affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of NEXN mRNA CTD PMID:19527780 NCBI chr 2:241,186,783...241,218,315
Ensembl chr 2:241,186,790...241,218,342 		JBrowse link
G Nmbr neuromedin B receptor increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of NMBR gene CTD PMID:25445006 NCBI chr 1:9,115,033...9,146,081
Ensembl chr 1:9,134,889...9,145,462 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of NQO1 mRNA CTD PMID:24211530 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Olr1433 olfactory receptor 1433 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of OR2W3 mRNA CTD PMID:19527780 NCBI chr10:43,042,427...43,046,293
Ensembl chr10:43,037,857...43,046,701 		JBrowse link
G Osbp2 oxysterol binding protein 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of OSBP2 mRNA CTD PMID:19527780 NCBI chr14:78,585,088...78,746,785
Ensembl chr14:78,585,089...78,746,786 		JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of RNMT promoter CTD PMID:25445006 NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775 		JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644 		JBrowse link
G Slc16a4 solute carrier family 16, member 4 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of SLC16A4 mRNA CTD PMID:19110044 NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117 		JBrowse link
G Slc25a28 solute carrier family 25 member 28 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of SLC25A28 gene CTD PMID:25445006 NCBI chr 1:242,530,877...242,542,140
Ensembl chr 1:242,530,899...242,542,115 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SLC7A11 mRNA CTD PMID:24211530 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of SOCS3 mRNA CTD PMID:19110044 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Specc1 sperm antigen with calponin homology and coiled-coil domains 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of SPECC1 gene CTD PMID:25445006 NCBI chr10:46,638,947...46,912,989
Ensembl chr10:46,638,809...46,912,802 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stc1 stanniocalcin 1 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of STC1 mRNA CTD PMID:19527780 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264 		JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO 1,6-hexamethylene diisocyanate results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:94,537,088...94,848,085
Ensembl chr 6:94,537,088...94,848,064 		JBrowse link
G Tlr2 toll-like receptor 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of TLR2 mRNA CTD PMID:19110044 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tmem253 transmembrane protein 253 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of TMEM253 promoter CTD PMID:25445006 NCBI chr15:24,706,517...24,709,107
Ensembl chr15:24,706,529...24,708,625 		JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO 1,6-hexamethylene diisocyanate results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 1,6-hexamethylene diisocyanate results in increased expression of TXNRD1 mRNA CTD PMID:24211530 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 affects expression ISO 1,6-hexamethylene diisocyanate affects the expression of UBA2 mRNA CTD PMID:19527780 NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682 		JBrowse link
G Ube2e1 ubiquitin-conjugating enzyme E2E 1 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of UBE2E1 promoter CTD PMID:25445006 NCBI chr15:7,439,751...7,493,410
Ensembl chr15:7,439,759...7,493,400 		JBrowse link
G Zfp219 zinc finger protein 219 increases methylation ISO 1,6-hexamethylene diisocyanate results in increased methylation of ZNF219 promoter CTD PMID:25445006 NCBI chr15:24,695,831...24,710,039
Ensembl chr15:24,695,837...24,710,030 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        hapten 3059
          hexamethylene diisocyanate 64
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      p-block molecular entity 19826
                        carbon group molecular entity 19766
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  isocyanates 347
                                    diisocyanate 308
                                      hexamethylene diisocyanate 64
paths to the root