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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cobalt(2+) sulfate
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Accession:CHEBI:53470 term browser browse the term
Definition:A compound of cobalt and sulfate in which the ratio of cobalt (+2 oxidation state) to sulfate is 1:1.
Synonyms:related_synonym: CoSO4;   Cobalt Brown;   Cobalt monosulfate;   Cobalt sulfate;   Cobalt(II) sulfate;   Cobaltous sulfate;   Formula=CoO4S;   InChI=1S/Co.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2;   InChIKey=KTVIXTQDYHMGHF-UHFFFAOYSA-L;   SMILES=[Co++].[O-]S([O-])(=O)=O
 xref: CAS:10026-24-1;   CAS:10124-43-3;   Gmelin:268815;   Gmelin:270126;   Gmelin:270959;   Gmelin:8292;   KEGG:C17383;   KEGG:C19215
 xref_mesh: MESH:C026305
 xref: PMID:2415590


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cobalt(2+) sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ak1 adenylate kinase 1 decreases expression ISO cobalt sulfate results in decreased expression of AK1 mRNA CTD PMID:19502547 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO cobalt sulfate results in increased expression of ALDOA mRNA CTD PMID:19502547 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Ankrd37 ankyrin repeat domain 37 increases expression ISO cobalt sulfate results in increased expression of ANKRD37 mRNA CTD PMID:19502547 NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP cobalt sulfate results in decreased expression of BAX protein CTD PMID:25310813 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Car9 carbonic anhydrase 9 increases expression ISO cobalt sulfate results in increased expression of CA9 mRNA CTD PMID:19502547 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Casp3 caspase 3 decreases expression EXP cobalt sulfate results in decreased expression of CASP3 protein CTD PMID:25310813 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion
increases expression		 ISO cobalt sulfate results in increased secretion of CCL4 protein
cobalt sulfate results in increased expression of CCL4 mRNA		 CTD PMID:16314067 PMID:20713136 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO cobalt sulfate results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO cobalt sulfate results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases expression ISO cobalt sulfate results in increased expression of EGLN1 mRNA CTD PMID:19502547 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 decreases expression ISO cobalt sulfate results in decreased expression of EGLN2 mRNA CTD PMID:19502547 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751 		JBrowse link
G Eno1 enolase 1 increases expression ISO cobalt sulfate results in increased expression of ENO1 mRNA CTD PMID:19502547 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Eno2 enolase 2 increases expression ISO cobalt sulfate results in increased expression of ENO2 mRNA CTD PMID:19502547 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO cobalt sulfate results in increased expression of FOS mRNA CTD PMID:10362023 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO cobalt sulfate results in increased expression of GAPDH mRNA CTD PMID:19502547 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity		 ISO HIF1A protein promotes the reaction [cobalt sulfate results in increased expression of VEGFA protein]
cobalt sulfate results in increased activity of HIF1A protein		 CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha decreases expression ISO cobalt sulfate results in decreased expression of HIF3A mRNA CTD PMID:19502547 NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758 		JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated increases expression ISO cobalt sulfate results in increased expression of HILPDA mRNA CTD PMID:19502547 NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO cobalt sulfate results in increased expression of HK2 mRNA CTD PMID:19502547 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO cobalt sulfate results in increased expression of HMOX1 mRNA CTD PMID:20713136 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Igf1 insulin-like growth factor 1 increases secretion EXP cobalt sulfate results in increased secretion of IGF1 protein CTD PMID:25310813 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO cobalt sulfate results in increased expression of IL1B mRNA CTD PMID:20713136 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il7r interleukin 7 receptor increases expression ISO cobalt sulfate results in increased expression of IL7R mRNA CTD PMID:20713136 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO cobalt sulfate results in increased expression of LDHA mRNA CTD PMID:19502547 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO cobalt sulfate results in increased expression of MIF mRNA CTD PMID:19502547 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mt2A metallothionein 2A increases expression ISO cobalt sulfate results in increased expression of MT2A mRNA CTD PMID:10362023 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Nppb natriuretic peptide B increases expression ISO cobalt sulfate results in increased expression of NPPB mRNA CTD PMID:19502547 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression ISO cobalt sulfate results in increased expression of PDK1 mRNA CTD PMID:19502547 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO cobalt sulfate results in increased expression of PGK1 mRNA CTD PMID:19502547 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO cobalt sulfate results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta decreases expression ISO cobalt sulfate results in decreased expression of PPP2R1B mRNA CTD PMID:19502547 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485 		JBrowse link
G Tfrc transferrin receptor increases expression ISO cobalt sulfate results in increased expression of TFRC mRNA CTD PMID:19502547 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO cobalt sulfate results in increased expression of TNFAIP3 mRNA CTD PMID:20713136 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO cobalt sulfate results in increased expression of TNFAIP6 mRNA CTD PMID:20713136 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
increases expression
multiple interactions		 ISO cobalt sulfate results in decreased expression of VEGFA mRNA
cobalt sulfate results in increased expression of VEGFA protein
HIF1A protein promotes the reaction [cobalt sulfate results in increased expression of VEGFA protein]		 CTD PMID:19502547 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          cofactor 16588
            cobalt(2+) 4273
              cobalt(2+) sulfate 35
                cobalt(2+) sulfate heptahydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      chalcogen 19598
                        oxygen atom 19570
                          oxygen molecular entity 19570
                            hydroxides 19374
                              oxoacid 18808
                                chalcogen oxoacid 13794
                                  sulfur oxoacid 13562
                                    sulfuric acid 8248
                                      sulfuric acid derivative 8251
                                        sulfates 8243
                                          sulfate salt 7137
                                            inorganic sulfate salt 7079
                                              metal sulfate 7066
                                                cobalt(2+) sulfate 35
                                                  cobalt(2+) sulfate heptahydrate 0
paths to the root