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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chromium(3+) trichloride
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Accession:CHEBI:53351 term browser browse the term
Definition:A chromium chloride with the chromium cation in the +3 oxidation state.
Synonyms:related_synonym: Chromic chloride;   Chromium chloride;   Chromium trichloride;   Chromium(III) chloride;   CrCl3;   Formula=Cl3Cr;   InChI=1S/3ClH.Cr/h3*1H;/q;;;+3/p-3;   InChIKey=QSWDMMVNRMROPK-UHFFFAOYSA-K;   Puratronic chromium chloride;   SMILES=[Cl-].[Cl-].[Cl-].[Cr+3];   Trichlorochromium;   anhydrous chromium(III) chloride
 xref: CAS:10025-73-7;   CAS:39345-92-1;   Drug_Central:5118;   Gmelin:130477;   Gmelin:1890;   Gmelin:532690
 xref_mesh: MESH:C022990
 xref: PMID:1108802;   PMID:1254974;   PMID:16349963;   PMID:19013231;   PMID:20237381;   PMID:29079364;   PMID:5112173;   PMID:670731;   PMID:7351481;   Patent:CN101456852;   Patent:CN101473776;   Patent:CN101632832;   Patent:CN101863755;   Reaxys:3903065;   Wikipedia:Chromium(III)_chloride


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chromium(3+) trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
decreases expression 		ISO [cobaltous chloride co-treated with chromic chloride] results in decreased expression of ALPL protein
chromic chloride results in decreased expression of ALPL protein 		CTD PMID:25966675 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Aspm assembly factor for spindle microtubules increases expression ISO chromic chloride results in increased expression of ASPM mRNA CTD PMID:12128095 NCBI chr13:53,625,584...53,674,489
Ensembl chr13:53,625,584...53,674,489 		JBrowse link
G Bach2 BTB domain and CNC homolog 2 increases expression ISO chromic chloride results in increased expression of BACH2 mRNA CTD PMID:12128095 NCBI chr 5:51,428,802...51,779,030
Ensembl chr 5:51,434,870...51,774,234 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO chromic chloride results in increased expression of BAX protein CTD PMID:14741615 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO chromic chloride results in decreased expression of BCL2 protein CTD PMID:14741615 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO chromic chloride results in increased expression of BTG2 mRNA CTD PMID:12128095 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO chromic chloride results in increased expression of and results in increased activity of CASP3 protein CTD PMID:14741615 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO chromic chloride results in increased expression of and results in increased activity of CASP8 protein CTD PMID:14741615 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Cat catalase increases activity EXP chromic chloride results in increased activity of CAT protein CTD PMID:21888059 PMID:23413686 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions 		ISO chromic chloride results in increased expression of CCL2 protein
chromic chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein]
[cobaltous chloride co-treated with chromic chloride] results in increased expression of CCL2 mRNA 		CTD PMID:17665966 PMID:23629852 PMID:25966675 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO chromic chloride results in increased expression of CDC25A mRNA CTD PMID:12128095 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188 		JBrowse link
G Eng endoglin increases expression ISO chromic chloride results in increased expression of ENG mRNA CTD PMID:12128095 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP chromic chloride results in increased activity of GSR protein CTD PMID:21888059 PMID:23413686 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO chromic chloride results in increased expression of ICAM1 protein CTD PMID:23629852 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
increases expression 		EXP
ISO 		chromic chloride promotes the reaction [INS1 protein results in increased expression of IGF1 mRNA]
chromic chloride results in increased expression of IGF1 mRNA 		CTD PMID:12153762 PMID:20013160 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 decreases expression ISO chromic chloride results in decreased expression of IGFBP1 mRNA CTD PMID:12153762 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:86,261,277...86,266,344 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		ISO chromic chloride inhibits the reaction [Glucose results in increased secretion of IL6 protein]; chromic chloride promotes the reaction [Estradiol inhibits the reaction [Glucose results in increased secretion of IL6 protein]]
chromic chloride results in increased expression of IL6 mRNA
[cobaltous chloride co-treated with chromic chloride] results in increased expression of IL6 mRNA 		CTD PMID:15528032 PMID:17665966 PMID:25966675 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP chromic chloride promotes the reaction [INS1 protein results in decreased expression of UBC mRNA]; chromic chloride promotes the reaction [INS1 protein results in increased expression of IGF1 mRNA] CTD PMID:20013160 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ins2 insulin 2 multiple interactions
increases activity 		ISO [chromic chloride results in increased activity of INS protein modified form] which results in increased import of Glucose; [chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate; Mannose inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate]; Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] CTD PMID:17965850 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Insr insulin receptor increases expression EXP chromic chloride results in increased expression of INSR mRNA CTD PMID:19283340 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:5,981,835...6,128,803 		JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] affects the expression of LRP5 mRNA CTD PMID:25966675 NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822 		JBrowse link
G Ly6d lymphocyte antigen 6 family member D decreases expression ISO chromic chloride results in decreased expression of LY6D mRNA CTD PMID:12128095 NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:108,532,215...108,533,716 		JBrowse link
G Mtf2 metal response element binding transcription factor 2 increases expression ISO chromic chloride results in increased expression of MTF2 mRNA CTD PMID:12128095 NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,783,627...1,828,414 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] results in increased expression of NFATC1 mRNA CTD PMID:25966675 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:76,321,386...76,430,990 		JBrowse link
G Pon1 paraoxonase 1 increases expression ISO chromic chloride results in increased expression of PON1 mRNA CTD PMID:12128095 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] affects the expression of RUNX2 mRNA CTD PMID:25966675 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G Sephs2 selenophosphate synthetase 2 increases expression ISO chromic chloride results in increased expression of SEPHS2 mRNA CTD PMID:12128095 NCBI chr 1:181,893,146...181,895,464
Ensembl chr 1:191,323,641...191,325,955 		JBrowse link
G Serpina1 serpin family A member 1 decreases activity EXP
ISO 		chromic chloride results in decreased activity of SERPINA1 protein CTD PMID:12122574 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:128,619,382...128,660,703 		JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 increases expression ISO chromic chloride results in increased expression of SGPL1 mRNA CTD PMID:12128095 NCBI chr20:29,047,793...29,094,209
Ensembl chr20:29,592,721...29,667,753 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization ISO chromic chloride affects the localization of SLC2A4 protein CTD PMID:16339278 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Sp7 Sp7 transcription factor multiple interactions
decreases expression 		ISO [cobaltous chloride co-treated with chromic chloride] results in decreased expression of SP7 mRNA
chromic chloride results in decreased expression of SP7 mRNA 		CTD PMID:25966675 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:135,363,199...135,373,559 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chromic chloride inhibits the reaction [[Hydrogen Peroxide co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]
[cobaltous chloride co-treated with chromic chloride] results in increased expression of TNF mRNA 		CTD PMID:11726202 PMID:25966675 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
decreases expression 		ISO [cobaltous chloride co-treated with chromic chloride] results in decreased expression of TNFRSF11B mRNA
chromic chloride results in decreased expression of TNFRSF11B mRNA 		CTD PMID:25966675 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:87,456,319...87,485,075 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [cobaltous chloride co-treated with chromic chloride] results in increased expression of TNFSF11 mRNA CTD PMID:25966675 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Ubc ubiquitin C decreases expression
multiple interactions 		EXP chromic chloride results in decreased expression of UBC mRNA
chromic chloride promotes the reaction [INS1 protein results in decreased expression of UBC mRNA] 		CTD PMID:20013160 NCBI chr12:31,239,149...31,243,924
Ensembl chr12:36,900,127...36,905,275 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        aetiopathogenetic role 19855
          sensitiser 9896
            chromium(3+) trichloride 35
              chromium(3+) trichloride hexahydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  metal atom 18405
                    transition element atom 17948
                      d-block element atom 17943
                        chromium group element atom 7995
                          chromium atom 6853
                            chromium molecular entity 6826
                              chromium coordination entity 5640
                                chromium halide 35
                                  chromium chloride 35
                                    chromium(3+) trichloride 35
                                      chromium(3+) trichloride hexahydrate 0
paths to the root