Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isophorone diisocyanate
go back to main search page
Accession:CHEBI:53214 term browser browse the term
Definition:A diisocyanate in which the two isocyanate groups are linked by an isophorone substituent.
Synonyms:exact_synonym: 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethylcyclohexane
 related_synonym: 3-Isocyanatomethyl-3,5,5-trimethylcyclohexylisocyanate;   Formula=C12H18N2O2;   IPDI;   InChI=1S/C12H18N2O2/c1-11(2)4-10(14-9-16)5-12(3,6-11)7-13-8-15/h10H,4-7H2,1-3H3;   InChIKey=NIMLQBUJDJZYEJ-UHFFFAOYSA-N;   Isocyanic acid, methylene(3,5,5-trimethyl-3,1-cyclohexylene) ester;   Isophorone diamine diisocyanate;   SMILES=CC1(C)CC(CC(C)(CN=C=O)C1)N=C=O
 xref: CAS:4098-71-9
 xref_mesh: MESH:C015301
 xref: PMID:1447476;   PMID:19851844;   PMID:20817708;   PMID:22237013;   PMID:23218325;   PMID:23394610;   PMID:23484438;   PMID:23548862;   PMID:23564646;   PMID:23648023;   Wikipedia:Isophorone_diisocyanate



show annotations for term's descendants           Sort by:
isophorone diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions
EXP isophorone diisocyanate results in increased expression of CXCL8 mRNA
[isophorone diisocyanate co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA
CTD PMID:29594315 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G IL10 interleukin 10 increases expression ISO isophorone diisocyanate results in increased expression of IL10 protein CTD PMID:19422874 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL13 interleukin 13 increases secretion ISO isophorone diisocyanate results in increased secretion of IL13 protein CTD PMID:17693426 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL1B interleukin 1 beta decreases expression EXP isophorone diisocyanate results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions EXP [isophorone diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL4 interleukin 4 increases expression
increases secretion
ISO isophorone diisocyanate results in increased expression of IL4 protein
isophorone diisocyanate results in increased secretion of IL4 protein
CTD PMID:17693426 PMID:19422874 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 affects the susceptibility to isophorone diisocyanate CTD PMID:23564646 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26503
    role 26326
      application 25592
        solvent 19119
          isophorone 10
            isophorone diisocyanate 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 26503
    subatomic particle 26479
      composite particle 26479
        hadron 26479
          baryon 26479
            nucleon 26479
              atomic nucleus 26479
                atom 26479
                  main group element atom 26217
                    p-block element atom 26217
                      carbon group element atom 25662
                        carbon atom 25624
                          organic molecular entity 25624
                            heteroorganic entity 25012
                              organochalcogen compound 24605
                                organooxygen compound 24201
                                  carbonyl compound 23679
                                    ketone 19582
                                      alpha,beta-unsaturated ketone 10576
                                        enone 10576
                                          isophorone 10
                                            isophorone diisocyanate 7
paths to the root