Gentiopicrin - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	Gentiopicrin	go back to main search page
Accession:	CHEBI:5321	browse the term
Definition:	A glycoside that has formula C16H20O9.
Synonyms:	related_synonym:	Formula=C16H20O9; Gentiopicroside; InChI=1S/C16H20O9/c1-2-7-8-3-4-22-14(21)9(8)6-23-15(7)25-16-13(20)12(19)11(18)10(5-17)24-16/h2-3,6-7,10-13,15-20H,1,4-5H2/t7-,10-,11-,12+,13-,15+,16+/m1/s1; InChIKey=DUAGQYUORDTXOR-GPQRQXLASA-N; SMILES=OC[C@H]1O[C@@H](O[C@@H]2OC=C3C(=O)OCC=C3[C@H]2C=C)[C@H](O)[C@@H](O)[C@@H]1O
	xref:	CAS:20831-76-9; KEGG:C09782; KNApSAcK:C00003082
	xref_mesh:	MESH:C012997

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Genes (20)

Gentiopicrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

multiple interactions

Gentiopicrin reverses the interaction [1-naphthyl isothiocyanate decreases expression of MRP4 mRNA in rat liver]

RGD

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

BCL2 associated X, apoptosis regulator

multiple interactions

gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

gentiopicroside inhibits the reaction [[[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP3 protein] which results in increased cleavage of PARP1 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP3 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP3 protein modified form]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP8 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP8 protein modified form]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP9 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CASP9 protein modified form]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin-dependent kinase 5 regulatory subunit 1

multiple interactions

gentiopicroside analog inhibits the reaction [Galactose results in increased expression of CDK5R1 protein]

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

catenin beta 1

multiple interactions

gentiopicroside analog inhibits the reaction [Galactose results in decreased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome c, somatic

multiple interactions

gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased localization of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

Gentiopicrin decreases expression of Cyp7a1 mRNA in rat ANIT induced cholestatic liver

RGD

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

glycogen synthase kinase 3 beta

multiple interactions

gentiopicroside analog inhibits the reaction [Galactose results in increased expression of and results in decreased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

LDL receptor related protein 6

multiple interactions

[Galactose co-treated with gentiopicroside analog] results in increased expression of LRP6 protein

NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497

G

mitogen activated protein kinase 1

multiple interactions

gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of MAPK1 protein modified form]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of MAPK3 protein modified form]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

gentiopicroside analog inhibits the reaction [Galactose results in increased expression of MAPT protein]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

Gentiopicrin reverses the reaction [1-naphthyl isothiocyanate decreases expression of Nr1h4 mRNA in rat liver]

RGD

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

poly (ADP-ribose) polymerase 1

multiple interactions

gentiopicroside inhibits the reaction [[[Galactosamine co-treated with Lipopolysaccharides] results in increased cleavage of and results in increased activity of CASP3 protein] which results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

presenilin enhancer gamma secretase subunit

multiple interactions

gentiopicroside analog inhibits the reaction [Galactose results in increased expression of PSENEN protein]

NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192

G

RE1-silencing transcription factor

multiple interactions

gentiopicroside analog inhibits the reaction [Galactose results in decreased expression of REST protein]

NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354

G

tumor necrosis factor

multiple interactions

gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
chemical entity	19872
atom	19872
nonmetal atom	19794
oxygen atom	19535
oxygen molecular entity	19535
organooxygen compound	19184
carbohydrates and carbohydrate derivatives	15285
carbohydrate derivative	14300
glycosyl compound	13062
glycoside	11830
Gentiopicrin	20
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
main group element atom	19811
p-block element atom	19811
carbon group element atom	19751
carbon atom	19748
organic molecular entity	19748
heteroorganic entity	19505
organochalcogen compound	19268
organooxygen compound	19184
carbohydrates and carbohydrate derivatives	15285
carbohydrate	15285
carbohydrate derivative	14300
glycosyl compound	13062
glycoside	11830
Gentiopicrin	20

paths to the root