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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apo carotenoid
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Accession:CHEBI:53183 term browser browse the term
Definition:A compound arising from loss of part of the carotene skeleton (excluding retinoids)
Synonyms:related_synonym: apo carotenoids;   apocarotenoid;   apocarotenoids


show annotations for term's descendants           Sort by:
(+)-abscisic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion
multiple interactions		 ISO CCL2 protein results in increased secretion of Abscisic Acid
fluridone inhibits the reaction [CCL2 protein results in increased secretion of Abscisic Acid]		 CTD PMID:24211328 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
8'-apo-beta,psi-caroten-8'-al term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-Coenzyme A dehydrogenase, medium chain increases expression ISO apocarotenal results in increased expression of ACADM mRNA CTD PMID:17034753 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases expression ISO apocarotenal results in increased expression of ADH5 mRNA CTD PMID:17034753 NCBI chr 3:138,142,961...138,161,260
Ensembl chr 3:138,148,854...138,161,260 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression ISO apocarotenal results in decreased expression of ALDH1B1 mRNA CTD PMID:17034753 NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604 		JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 decreases expression ISO apocarotenal results in decreased expression of ALDH3B1 mRNA CTD PMID:17034753 NCBI chr19:3,963,491...3,980,898
Ensembl chr19:3,963,491...3,979,808 		JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 decreases expression ISO apocarotenal results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 NCBI chr 4:139,348,404...139,377,002
Ensembl chr 4:139,350,177...139,377,001 		JBrowse link
G Ank2 ankyrin 2, brain increases expression ISO apocarotenal results in increased expression of ANK2 mRNA CTD PMID:17034753 NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999 		JBrowse link
G Ank3 ankyrin 3, epithelial increases expression ISO apocarotenal results in increased expression of ANK3 mRNA CTD PMID:17034753 NCBI chr10:69,234,608...69,863,266
Ensembl chr10:69,234,603...69,863,268 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO apocarotenal results in increased expression of ASAH1 mRNA CTD PMID:17034753 NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810 		JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO apocarotenal results in increased expression of ASB1 mRNA CTD PMID:17034753 NCBI chr 1:91,467,725...91,487,312
Ensembl chr 1:91,468,266...91,487,311 		JBrowse link
G Asb9 ankyrin repeat and SOCS box-containing 9 increases expression ISO apocarotenal results in increased expression of ASB9 mRNA CTD PMID:17034753 NCBI chr  X:163,280,899...163,322,748
Ensembl chr  X:163,289,323...163,322,748 		JBrowse link
G Bax BCL2-associated X protein decreases expression ISO apocarotenal results in decreased expression of BAX mRNA CTD PMID:17034753 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bco2 beta-carotene oxygenase 2 multiple interactions EXP [BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Cryptoxanthins] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite; [BCO2 protein results in increased metabolism of Zeaxanthins] which results in increased chemical synthesis of apocarotenal metabolite CTD PMID:21106934 NCBI chr 9:50,444,387...50,466,513
Ensembl chr 9:50,444,387...50,466,481 		JBrowse link
G Casp8ap2 caspase 8 associated protein 2 increases expression ISO apocarotenal results in increased expression of CASP8AP2 mRNA CTD PMID:17034753 NCBI chr 4:32,615,462...32,653,271
Ensembl chr 4:32,615,451...32,653,265 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO apocarotenal results in increased expression of CDH1 mRNA CTD PMID:17034753 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cldn10 claudin 10 increases expression ISO apocarotenal results in increased expression of CLDN10 mRNA CTD PMID:17034753 NCBI chr14:119,025,283...119,111,937
Ensembl chr14:119,025,320...119,112,901 		JBrowse link
G Cldn18 claudin 18 increases expression ISO apocarotenal results in increased expression of CLDN18 mRNA CTD PMID:17034753 NCBI chr 9:99,572,849...99,599,320
Ensembl chr 9:99,571,514...99,599,320 		JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression ISO apocarotenal results in decreased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col4a1 collagen, type IV, alpha 1 decreases expression ISO apocarotenal results in decreased expression of COL4A1 mRNA CTD PMID:17034753 NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826 		JBrowse link
G Col4a2 collagen, type IV, alpha 2 decreases expression ISO apocarotenal results in decreased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr 8:11,362,878...11,499,287
Ensembl chr 8:11,362,805...11,499,287 		JBrowse link
G Crabp2 cellular retinoic acid binding protein II decreases expression ISO apocarotenal results in decreased expression of CRABP2 mRNA CTD PMID:17034753 NCBI chr 3:87,856,000...87,860,679
Ensembl chr 3:87,855,973...87,860,683 		JBrowse link
G Ctsb cathepsin B decreases expression ISO apocarotenal results in decreased expression of CTSB mRNA CTD PMID:17034753 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO apocarotenal results in increased expression of CXCL12 mRNA CTD PMID:17034753 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cxcl5 C-X-C motif chemokine ligand 5 increases expression ISO apocarotenal results in increased expression of CXCL6 mRNA CTD PMID:17034753 NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO apocarotenal results in increased expression of CXCL9 mRNA CTD PMID:17034753 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO apocarotenal results in increased expression of CXCR4 mRNA CTD PMID:17034753 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases expression ISO apocarotenal results in increased expression of CYP2C9 mRNA CTD PMID:17034753 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Dlx2 distal-less homeobox 2 increases expression ISO apocarotenal results in increased expression of DLX2 mRNA CTD PMID:17034753 NCBI chr 2:71,373,752...71,377,095
Ensembl chr 2:71,373,752...71,377,098 		JBrowse link
G Dlx4 distal-less homeobox 4 increases expression ISO apocarotenal results in increased expression of DLX4 mRNA CTD PMID:17034753 NCBI chr11:95,031,273...95,037,116
Ensembl chr11:95,031,273...95,037,089 		JBrowse link
G Ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 decreases expression ISO apocarotenal results in decreased expression of ERCC2 mRNA CTD PMID:17034753 NCBI chr 7:19,115,942...19,129,619
Ensembl chr 7:19,115,935...19,129,619 		JBrowse link
G Ets1 E26 avian leukemia oncogene 1, 5' domain decreases expression ISO apocarotenal results in decreased expression of ETS1 mRNA CTD PMID:17034753 NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO apocarotenal results in increased expression of FAS mRNA CTD PMID:17034753 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasn fatty acid synthase decreases expression ISO apocarotenal results in decreased expression of FASN mRNA CTD PMID:17034753 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO apocarotenal results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635 		JBrowse link
G Gbp2b guanylate binding protein 2b increases expression ISO apocarotenal results in increased expression of GBP1 mRNA CTD PMID:17034753 NCBI chr 3:142,300,577...142,324,940
Ensembl chr 3:142,300,608...142,324,940 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO apocarotenal results in decreased expression of GSTK1 mRNA CTD PMID:17034753 NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381 		JBrowse link
G Gstm2 glutathione S-transferase, mu 2 decreases expression ISO apocarotenal results in decreased expression of GSTM2 mRNA CTD PMID:17034753 NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769 		JBrowse link
G Gstm4 glutathione S-transferase, mu 4 decreases expression ISO apocarotenal results in decreased expression of GSTM4 mRNA CTD PMID:17034753 NCBI chr 3:107,937,887...107,952,495
Ensembl chr 3:107,947,724...107,952,210 		JBrowse link
G Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) decreases expression ISO apocarotenal results in decreased expression of GSTZ1 mRNA CTD PMID:17034753 NCBI chr12:87,192,102...87,211,497
Ensembl chr12:87,193,939...87,211,497 		JBrowse link
G Hoxa7 homeobox A7 increases expression ISO apocarotenal results in increased expression of HOXA7 mRNA CTD PMID:17034753 NCBI chr 6:52,191,471...52,198,757
Ensembl chr 6:52,191,471...52,198,834 		JBrowse link
G Hoxb6 homeobox B6 increases expression ISO apocarotenal results in increased expression of HOXB6 mRNA CTD PMID:17034753 NCBI chr11:96,183,647...96,192,395
Ensembl chr11:96,183,302...96,192,395 		JBrowse link
G Hoxc10 homeobox C10 increases expression ISO apocarotenal results in increased expression of HOXC10 mRNA CTD PMID:17034753 NCBI chr15:102,875,231...102,880,333
Ensembl chr15:102,875,231...102,880,328 		JBrowse link
G Irf8 interferon regulatory factor 8 increases expression ISO apocarotenal results in increased expression of IRF8 mRNA CTD PMID:17034753 NCBI chr 8:121,463,097...121,483,433
Ensembl chr 8:121,463,097...121,483,433 		JBrowse link
G Irx4 Iroquois homeobox 4 decreases expression ISO apocarotenal results in decreased expression of IRX4 mRNA CTD PMID:17034753 NCBI chr13:73,407,708...73,417,741
Ensembl chr13:73,408,598...73,417,727 		JBrowse link
G Itgb4 integrin beta 4 decreases expression ISO apocarotenal results in decreased expression of ITGB4 mRNA CTD PMID:17034753 NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238 		JBrowse link
G Ivl involucrin increases expression ISO apocarotenal results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 3:92,478,206...92,481,097
Ensembl chr 3:92,478,209...92,481,042 		JBrowse link
G Krt17 keratin 17 decreases expression ISO apocarotenal results in decreased expression of KRT17 mRNA CTD PMID:17034753 NCBI chr11:100,147,041...100,151,855
Ensembl chr11:100,147,043...100,151,855 		JBrowse link
G Krt2 keratin 2 increases expression ISO apocarotenal results in increased expression of KRT2 mRNA CTD PMID:17034753 NCBI chr15:101,719,124...101,727,391
Ensembl chr15:101,719,124...101,726,604 		JBrowse link
G Krt7 keratin 7 affects expression ISO apocarotenal affects the expression of KRT7 mRNA CTD PMID:17034753 NCBI chr15:101,310,284...101,325,687
Ensembl chr15:101,308,924...101,328,194 		JBrowse link
G Lhx3 LIM homeobox protein 3 increases expression ISO apocarotenal results in increased expression of LHX3 mRNA CTD PMID:17034753 NCBI chr 2:26,090,224...26,098,261
Ensembl chr 2:26,090,224...26,098,301 		JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 affects expression ISO apocarotenal affects the expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487 		JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO apocarotenal results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 2:115,691,745...115,897,925
Ensembl chr 2:115,693,545...115,896,320 		JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO apocarotenal results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr11:101,768,336...101,785,309
Ensembl chr11:101,768,336...101,785,200 		JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 increases expression ISO apocarotenal results in increased expression of MNX1 mRNA CTD PMID:17034753 NCBI chr 5:29,678,821...29,683,468
Ensembl chr 5:29,678,032...29,683,468 		JBrowse link
G Msh5 mutS homolog 5 increases expression ISO apocarotenal results in increased expression of MSH5 mRNA CTD PMID:17034753 NCBI chr17:35,247,581...35,267,842
Ensembl chr17:35,247,581...35,265,721 		JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric increases expression ISO apocarotenal results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal increases expression ISO apocarotenal results in increased expression of NOS1 mRNA CTD PMID:17034753 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression ISO apocarotenal results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128 		JBrowse link
G Pcdhgc3 protocadherin gamma subfamily C, 3 increases expression ISO apocarotenal results in increased expression of PCDHGC3 mRNA CTD PMID:17034753 NCBI chr18:37,939,463...37,974,926
Ensembl chr18:37,939,417...37,974,926 		JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO apocarotenal results in increased expression of PLSCR1 mRNA CTD PMID:17034753 NCBI chr 9:92,132,265...92,154,034
Ensembl chr 9:92,131,803...92,154,331 		JBrowse link
G Plscr3 phospholipid scramblase 3 increases expression ISO apocarotenal results in increased expression of PLSCR3 mRNA CTD PMID:17034753 NCBI chr11:69,734,937...69,742,884
Ensembl chr11:69,737,202...69,742,884 		JBrowse link
G Plscr4 phospholipid scramblase 4 increases expression ISO apocarotenal results in increased expression of PLSCR4 mRNA CTD PMID:17034753 NCBI chr 9:92,339,431...92,374,509
Ensembl chr 9:92,339,426...92,374,509 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO apocarotenal results in increased expression of RAD51AP1 mRNA CTD PMID:17034753 NCBI chr 6:126,900,378...126,916,664
Ensembl chr 6:126,900,013...126,916,550 		JBrowse link
G Rad51d RAD51 paralog D increases expression ISO apocarotenal results in increased expression of RAD51D mRNA CTD PMID:17034753 NCBI chr11:82,762,786...82,781,571
Ensembl chr11:82,767,260...82,781,440 		JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO apocarotenal results in decreased expression of RARA mRNA CTD PMID:17034753 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO apocarotenal results in increased expression of RARB mRNA CTD PMID:17034753 NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924 		JBrowse link
G Rarres1 retinoic acid receptor responder (tazarotene induced) 1 increases expression ISO apocarotenal results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 3:67,386,219...67,422,856
Ensembl chr 3:67,386,305...67,422,856 		JBrowse link
G Six6 sine oculis-related homeobox 6 increases expression ISO apocarotenal results in increased expression of SIX6 mRNA CTD PMID:17034753 NCBI chr12:72,986,656...72,991,673
Ensembl chr12:72,986,666...72,991,673 		JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression ISO apocarotenal results in decreased expression of SOD1 mRNA CTD PMID:17034753 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 affects expression ISO apocarotenal affects the expression of SPTLC2 mRNA CTD PMID:17034753 NCBI chr12:87,351,832...87,435,129
Ensembl chr12:87,351,832...87,435,129 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO apocarotenal results in increased expression of SREBF1 mRNA CTD PMID:17034753 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Tgm4 transglutaminase 4 (prostate) increases expression ISO apocarotenal results in increased expression of TGM4 mRNA CTD PMID:17034753 NCBI chr 9:122,863,806...122,896,623
Ensembl chr 9:122,863,791...122,896,626 		JBrowse link
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 increases expression ISO apocarotenal results in increased expression of TNFRSF9 mRNA CTD PMID:17034753 NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559 		JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 increases expression ISO apocarotenal results in increased expression of TNFSF10 mRNA CTD PMID:17034753 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576 		JBrowse link
G Txndc9 thioredoxin domain containing 9 increases expression ISO apocarotenal results in increased expression of TXNDC9 mRNA CTD PMID:17034753 NCBI chr 1:38,022,385...38,036,324
Ensembl chr 1:38,024,270...38,036,974 		JBrowse link
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 increases expression ISO apocarotenal results in increased expression of XRCC3 mRNA CTD PMID:17034753 NCBI chr12:111,769,626...111,780,326
Ensembl chr12:111,769,626...111,780,307 		JBrowse link
alpha-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gna15 guanine nucleotide binding protein, alpha 15 multiple interactions
increases response to substance		 ISO [GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OR1A1B protein CTD PMID:15598656 NCBI chr10:81,338,147...81,360,283
Ensembl chr10:81,338,140...81,360,059 		JBrowse link
G Or1a1b olfactory receptor family 1 subfamily A member 1B multiple interactions ISO [GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OR1A1B protein CTD PMID:15598656 NCBI chr11:74,097,024...74,098,115
Ensembl chr11:74,096,490...74,102,205 		JBrowse link
G Or51e2 olfactory receptor family 51 subfamily E member 2 decreases activity ISO alpha-ionone results in decreased activity of OR51E2 protein CTD PMID:27226631 NCBI chr 7:102,389,928...102,408,678
Ensembl chr 7:102,387,718...102,408,678 		JBrowse link
beta-damascenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12e arachidonate lipoxygenase, epidermal increases expression EXP beta-damascenone results in increased expression of ALOX12E mRNA CTD PMID:22982537 NCBI chr11:70,206,436...70,213,545
Ensembl chr11:70,206,436...70,213,454 		JBrowse link
G Calm4 calmodulin 4 increases expression EXP beta-damascenone results in increased expression of CALM4 mRNA CTD PMID:22982537 NCBI chr13:3,887,757...3,888,671
Ensembl chr13:3,887,757...3,888,673 		JBrowse link
G Casp14 caspase 14 increases expression
affects localization		 EXP beta-damascenone results in increased expression of CASP14 mRNA
beta-damascenone affects the localization of CASP14 protein		 CTD PMID:22982537 NCBI chr10:78,547,829...78,554,181
Ensembl chr10:78,547,825...78,554,128 		JBrowse link
G Ces3b carboxylesterase 3B increases expression EXP beta-damascenone results in increased expression of CES3 mRNA CTD PMID:22982537 NCBI chr 8:105,810,365...105,820,561
Ensembl chr 8:105,810,385...105,820,561 		JBrowse link
G Clca1 chloride channel accessory 1 increases expression EXP beta-damascenone results in increased expression of CLCA1 mRNA CTD PMID:22982537 NCBI chr 3:144,710,298...144,738,537
Ensembl chr 3:144,709,578...144,738,537 		JBrowse link
G Clca2 chloride channel accessory 2 increases expression EXP beta-damascenone results in increased expression of CLCA2 mRNA CTD PMID:22982537 NCBI chr 3:144,776,021...144,805,204
Ensembl chr 3:144,776,024...144,805,204 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression EXP beta-damascenone results in increased expression of CYP17A1 mRNA CTD PMID:22982537 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611 		JBrowse link
G Cyp2b19 cytochrome P450, family 2, subfamily b, polypeptide 19 increases expression EXP beta-damascenone results in increased expression of CYP2B19 mRNA CTD PMID:22982537 NCBI chr 7:26,456,567...26,472,055
Ensembl chr 7:26,456,567...26,472,055 		JBrowse link
G Fcgbp Fc fragment of IgG binding protein increases expression EXP beta-damascenone results in increased expression of FCGBP mRNA CTD PMID:22982537 NCBI chr 7:27,770,661...27,820,289
Ensembl chr 7:27,770,661...27,820,287 		JBrowse link
G Flg filaggrin increases expression EXP beta-damascenone results in increased expression of FLG mRNA; beta-damascenone results in increased expression of FLG protein CTD PMID:22982537 NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993 		JBrowse link
G Hrnr hornerin increases expression EXP beta-damascenone results in increased expression of HRNR mRNA CTD PMID:22982537 NCBI chr 3:93,227,056...93,240,879
Ensembl chr 3:93,227,056...93,240,877 		JBrowse link
G Il20ra interleukin 20 receptor, alpha increases expression EXP beta-damascenone results in increased expression of IL20RA mRNA CTD PMID:22982537 NCBI chr10:19,587,421...19,635,801
Ensembl chr10:19,588,318...19,635,801 		JBrowse link
G Il36rn interleukin 36 receptor antagonist increases expression EXP beta-damascenone results in increased expression of IL36RN mRNA CTD PMID:22982537 NCBI chr 2:24,166,966...24,172,444
Ensembl chr 2:24,166,966...24,173,438 		JBrowse link
G Krt1 keratin 1 increases expression EXP beta-damascenone results in increased expression of KRT1 mRNA CTD PMID:22982537 NCBI chr15:101,753,861...101,759,221
Ensembl chr15:101,753,861...101,759,229 		JBrowse link
G Krt10 keratin 10 increases expression EXP beta-damascenone results in increased expression of KRT10 mRNA CTD PMID:22982537 NCBI chr11:99,276,080...99,288,631
Ensembl chr11:99,276,080...99,280,190 		JBrowse link
G Lce1a2 late cornified envelope 1A2 increases expression EXP beta-damascenone results in increased expression of LCE1A2 mRNA CTD PMID:22982537 NCBI chr 3:92,575,920...92,577,622
Ensembl chr 3:92,575,920...92,577,622 		JBrowse link
G Lce1b late cornified envelope 1B increases expression EXP beta-damascenone results in increased expression of LCE1B mRNA CTD PMID:22982537 NCBI chr 3:92,562,957...92,564,233
Ensembl chr 3:92,562,957...92,564,233 		JBrowse link
G Lce1c late cornified envelope 1C increases expression EXP beta-damascenone results in increased expression of LCE1C mRNA CTD PMID:22982537 NCBI chr 3:92,586,554...92,588,225
Ensembl chr 3:92,586,554...92,588,225 		JBrowse link
G Lce1d late cornified envelope 1D increases expression EXP beta-damascenone results in increased expression of LCE1D mRNA CTD PMID:22982537 NCBI chr 3:92,592,806...92,594,517
Ensembl chr 3:92,592,806...92,594,517 		JBrowse link
G Lce1f late cornified envelope 1F increases expression EXP beta-damascenone results in increased expression of LCE1F mRNA CTD PMID:22982537 NCBI chr 3:92,626,003...92,627,657
Ensembl chr 3:92,625,992...92,627,657 		JBrowse link
G Lce1i late cornified envelope 1I increases expression EXP beta-damascenone results in increased expression of LCE1I mRNA CTD PMID:22982537 NCBI chr 3:92,684,517...92,686,206
Ensembl chr 3:92,684,517...92,686,206 		JBrowse link
G Lipm lipase, family member M increases expression EXP beta-damascenone results in increased expression of LIPM mRNA CTD PMID:22982537 NCBI chr19:34,078,343...34,100,087
Ensembl chr19:34,078,333...34,100,087 		JBrowse link
G Loricrin loricrin cornified envelope precursor protein increases expression EXP beta-damascenone results in increased expression of LORICRIN mRNA CTD PMID:22982537 NCBI chr 3:91,987,578...91,990,447
Ensembl chr 3:91,987,578...91,990,449 		JBrowse link
G Otop3 otopetrin 3 increases expression EXP beta-damascenone results in increased expression of OTOP3 mRNA CTD PMID:22982537 NCBI chr11:115,225,557...115,237,753
Ensembl chr11:115,225,557...115,237,753 		JBrowse link
G Pla2g4f phospholipase A2, group IVF increases expression EXP beta-damascenone results in increased expression of PLA2G4F mRNA CTD PMID:22982537 NCBI chr 2:120,130,433...120,144,646
Ensembl chr 2:120,130,438...120,144,646 		JBrowse link
G Plcxd1 phosphatidylinositol-specific phospholipase C, X domain containing 1 increases expression EXP beta-damascenone results in increased expression of PLCXD1 mRNA CTD PMID:22982537 NCBI chr 5:110,247,661...110,253,819
Ensembl chr 5:110,247,835...110,253,819 		JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 increases expression EXP beta-damascenone results in increased expression of SDR16C5 mRNA CTD PMID:22982537 NCBI chr 4:3,995,942...4,019,663
Ensembl chr 4:3,995,936...4,019,663 		JBrowse link
G Susd2 sushi domain containing 2 increases expression EXP beta-damascenone results in increased expression of SUSD2 mRNA CTD PMID:22982537 NCBI chr10:75,472,453...75,479,842
Ensembl chr10:75,472,540...75,479,842 		JBrowse link
G Tmprss4 transmembrane protease, serine 4 increases expression EXP beta-damascenone results in increased expression of TMPRSS4 mRNA CTD PMID:22982537 NCBI chr 9:45,084,024...45,115,417
Ensembl chr 9:45,084,024...45,115,390 		JBrowse link
beta-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression ISO beta-ionone results in increased expression of BAX protein CTD PMID:31506784 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions		 ISO beta-ionone results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; Hydroxychloroquine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; STK11 protein affects the reaction [beta-ionone results in decreased expression of BCL2 protein]		 CTD PMID:23100158 PMID:31506784 PMID:36843289 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression		 ISO [alpha-Tocopherol co-treated with beta-ionone] results in increased activity of CASP3 protein
beta-ionone results in increased cleavage of CASP3 protein
beta-ionone results in increased expression of CASP3 protein modified form		 CTD PMID:17618090 PMID:23100158 PMID:31506784 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO beta-ionone results in increased cleavage of CASP9 protein CTD PMID:36843289 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO beta-ionone results in decreased expression of CCND1 protein CTD PMID:15450939 PMID:31506784 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO beta-ionone results in decreased expression of CDK2 protein CTD PMID:15450939 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression ISO beta-ionone results in decreased expression of CDK4 protein CTD PMID:15450939 PMID:31506784 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cryz crystallin, zeta increases activity EXP beta-ionone results in increased activity of CRYZ protein CTD PMID:31506784 NCBI chr 3:154,302,348...154,328,819
Ensembl chr 3:154,302,348...154,328,819 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions ISO beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] CTD PMID:20435455 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Lmnb1 lamin B1 decreases farnesylation ISO beta-ionone results in decreased farnesylation of LMNB1 protein CTD PMID:10203554 NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO 3-methyladenine inhibits the reaction [beta-ionone results in increased expression of and results in increased lipidation of MAP1LC3B protein]; beta-ionone results in increased expression of and results in increased lipidation of MAP1LC3B protein; STK11 protein affects the reaction [beta-ionone results in increased lipidation of MAP1LC3B protein] CTD PMID:36843289 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO
EXP		 beta-ionone results in increased phosphorylation of MAPK1 protein
beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]		 CTD PMID:23268108 PMID:27226631 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]
beta-ionone results in increased phosphorylation of MAPK3 protein		 CTD PMID:23268108 PMID:27226631 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP beta-ionone inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:23268108 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:23268108 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Or51e2 olfactory receptor family 51 subfamily E member 2 multiple interactions ISO beta-ionone binds to and results in increased activity of OR51E2 protein CTD PMID:27226631 NCBI chr 7:102,389,928...102,408,678
Ensembl chr 7:102,387,718...102,408,678 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
increases cleavage		 ISO 3-methyladenine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; Hydroxychloroquine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; STK11 protein affects the reaction [beta-ionone results in increased cleavage of PARP1 protein] CTD PMID:36843289 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO		 beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
beta-ionone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:23268108 PMID:31506784 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP beta-ionone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:23268108 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions
increases phosphorylation		 ISO STK11 protein affects the reaction [beta-ionone results in decreased expression of BCL2 protein]; STK11 protein affects the reaction [beta-ionone results in increased cleavage of PARP1 protein]; STK11 protein affects the reaction [beta-ionone results in increased lipidation of MAP1LC3B protein]
beta-ionone results in increased phosphorylation of STK11 protein		 CTD PMID:36843289 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:23268108 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tyr tyrosinase increases expression ISO beta-ionone results in increased expression of TYR mRNA; beta-ionone results in increased expression of TYR protein CTD PMID:27226631 NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22289
    chemical entity 22288
      atom 22284
        nonmetal atom 22114
          carbon atom 21906
            organic molecular entity 21906
              isoprenoid 14765
                apo carotenoid 128
                  (3R)-3-hydroxy-10'-apo-beta-carotenal 0
                  (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal 0
                  10'-apo-beta-carotenal 0
                  13-apo-beta-carotenone 0
                  13-cis-10'-apo-lycopenal 0
                  2,6-dimethyldeca-2,4,6,8-tetraenedial 0
                  4,4'-diapolycopenedial 0
                  4,9-dimethyldodeca-2,4,6,8,10-pentaenedial 0
                  4-methylocta-2,4,6-trienedial 0
                  5-cis-10'-apo-lycopenal 0
                  6'-apo-beta-carotenal 0
                  9-cis-10'-apo-beta-carotenal 0
                  apo carotenoid C25 terpenoid + 0
                  apo carotenoid C35 terpenoid + 0
                  apo carotenoid diterpenoid + 0
                  apo carotenoid monoterpenoid + 53
                  apo carotenoid sesquiterpenoid + 1
                  apo carotenoid triterpenoid + 75
                  bixin dialdehyde 0
                  citranaxanthin 0
                  rosafluene 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22289
    subatomic particle 22284
      composite particle 22284
        hadron 22284
          baryon 22284
            nucleon 22284
              atomic nucleus 22284
                atom 22284
                  main group element atom 22164
                    main group molecular entity 22164
                      p-block molecular entity 22164
                        carbon group molecular entity 21966
                          organic molecular entity 21906
                            lipid 18911
                              isoprenoid 14765
                                apo carotenoid 128
                                  (3R)-3-hydroxy-10'-apo-beta-carotenal 0
                                  (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal 0
                                  10'-apo-beta-carotenal 0
                                  13-apo-beta-carotenone 0
                                  13-cis-10'-apo-lycopenal 0
                                  2,6-dimethyldeca-2,4,6,8-tetraenedial 0
                                  4,4'-diapolycopenedial 0
                                  4,9-dimethyldodeca-2,4,6,8,10-pentaenedial 0
                                  4-methylocta-2,4,6-trienedial 0
                                  5-cis-10'-apo-lycopenal 0
                                  6'-apo-beta-carotenal 0
                                  9-cis-10'-apo-beta-carotenal 0
                                  apo carotenoid C25 terpenoid + 0
                                  apo carotenoid C35 terpenoid + 0
                                  apo carotenoid diterpenoid + 0
                                  apo carotenoid monoterpenoid + 53
                                  apo carotenoid sesquiterpenoid + 1
                                  apo carotenoid triterpenoid + 75
                                  bixin dialdehyde 0
                                  citranaxanthin 0
                                  rosafluene 0
paths to the root