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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apo carotenoid
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Accession:CHEBI:53183 term browser browse the term
Definition:A compound arising from loss of part of the carotene skeleton (excluding retinoids)
Synonyms:related_synonym: apo carotenoids;   apocarotenoid;   apocarotenoids


show annotations for term's descendants           Sort by:
(+)-abscisic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 increases secretion
multiple interactions		 EXP CCL2 protein results in increased secretion of Abscisic Acid
fluridone inhibits the reaction [CCL2 protein results in increased secretion of Abscisic Acid]		 CTD PMID:24211328 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
8'-apo-beta,psi-caroten-8'-al term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADM acyl-CoA dehydrogenase medium chain increases expression EXP apocarotenal results in increased expression of ACADM mRNA CTD PMID:17034753 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575 		JBrowse link
G ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide increases expression EXP apocarotenal results in increased expression of ADH1A mRNA CTD PMID:17034753 NCBI chr 4:99,276,369...99,290,985
Ensembl chr 4:99,276,369...99,291,003 		JBrowse link
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide increases expression EXP apocarotenal results in increased expression of ADH5 mRNA CTD PMID:17034753 NCBI chr 4:99,070,978...99,088,788
Ensembl chr 4:99,070,978...99,088,801 		JBrowse link
G ALDH1B1 aldehyde dehydrogenase 1 family member B1 decreases expression EXP apocarotenal results in decreased expression of ALDH1B1 mRNA CTD PMID:17034753 NCBI chr 9:38,392,702...38,398,661
Ensembl chr 9:38,392,702...38,398,661 		JBrowse link
G ALDH3B1 aldehyde dehydrogenase 3 family member B1 decreases expression EXP apocarotenal results in decreased expression of ALDH3B1 mRNA CTD PMID:17034753 NCBI chr11:68,008,547...68,029,276
Ensembl chr11:68,008,578...68,029,282 		JBrowse link
G ALDH4A1 aldehyde dehydrogenase 4 family member A1 decreases expression EXP apocarotenal results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 NCBI chr 1:18,871,430...18,902,555
Ensembl chr 1:18,871,430...18,902,724 		JBrowse link
G ANK2 ankyrin 2 increases expression EXP apocarotenal results in increased expression of ANK2 mRNA CTD PMID:17034753 NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221 		JBrowse link
G ANK3 ankyrin 3 increases expression EXP apocarotenal results in increased expression of ANK3 mRNA CTD PMID:17034753 NCBI chr10:60,026,298...60,733,528
Ensembl chr10:60,026,298...60,733,490 		JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 increases expression EXP apocarotenal results in increased expression of ASAH1 mRNA CTD PMID:17034753 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998 		JBrowse link
G ASB1 ankyrin repeat and SOCS box containing 1 increases expression EXP apocarotenal results in increased expression of ASB1 mRNA CTD PMID:17034753 NCBI chr 2:238,426,927...238,452,250
Ensembl chr 2:238,426,742...238,452,250 		JBrowse link
G ASB9 ankyrin repeat and SOCS box containing 9 increases expression EXP apocarotenal results in increased expression of ASB9 mRNA CTD PMID:17034753 NCBI chr  X:15,243,987...15,270,467
Ensembl chr  X:15,235,288...15,270,467 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression EXP apocarotenal results in decreased expression of BAX mRNA CTD PMID:17034753 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCO2 beta-carotene oxygenase 2 multiple interactions ISO [BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Cryptoxanthins] which results in increased chemical synthesis of apocarotenal; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite; [BCO2 protein results in increased metabolism of Zeaxanthins] which results in increased chemical synthesis of apocarotenal metabolite CTD PMID:21106934 NCBI chr11:112,175,512...112,218,946
Ensembl chr11:112,175,510...112,224,699 		JBrowse link
G CASP8AP2 caspase 8 associated protein 2 increases expression EXP apocarotenal results in increased expression of CASP8AP2 mRNA CTD PMID:17034753 NCBI chr 6:89,829,880...89,874,436
Ensembl chr 6:89,829,894...89,874,436 		JBrowse link
G CDH1 cadherin 1 increases expression EXP apocarotenal results in increased expression of CDH1 mRNA CTD PMID:17034753 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CLDN10 claudin 10 increases expression EXP apocarotenal results in increased expression of CLDN10 mRNA CTD PMID:17034753 NCBI chr13:95,433,755...95,579,759
Ensembl chr13:95,433,604...95,579,759 		JBrowse link
G CLDN18 claudin 18 increases expression EXP apocarotenal results in increased expression of CLDN18 mRNA CTD PMID:17034753 NCBI chr 3:137,998,816...138,033,649
Ensembl chr 3:137,998,735...138,033,655 		JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression EXP apocarotenal results in decreased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL4A1 collagen type IV alpha 1 chain decreases expression EXP apocarotenal results in decreased expression of COL4A1 mRNA CTD PMID:17034753 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,202 		JBrowse link
G COL4A2 collagen type IV alpha 2 chain decreases expression EXP apocarotenal results in decreased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr13:110,307,284...110,513,209
Ensembl chr13:110,305,812...110,513,209 		JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 decreases expression EXP apocarotenal results in decreased expression of CRABP2 mRNA CTD PMID:17034753 NCBI chr 1:156,699,606...156,705,784
Ensembl chr 1:156,699,606...156,705,816 		JBrowse link
G CTSB cathepsin B decreases expression EXP apocarotenal results in decreased expression of CTSB mRNA CTD PMID:17034753 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 increases expression EXP apocarotenal results in increased expression of CXCL12 mRNA CTD PMID:17034753 NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 increases expression EXP apocarotenal results in increased expression of CXCL6 mRNA CTD PMID:17034753 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 increases expression EXP apocarotenal results in increased expression of CXCL9 mRNA CTD PMID:17034753 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression EXP apocarotenal results in increased expression of CXCR4 mRNA CTD PMID:17034753 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases expression EXP apocarotenal results in increased expression of CYP2C9 mRNA CTD PMID:17034753 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G DLX2 distal-less homeobox 2 increases expression EXP apocarotenal results in increased expression of DLX2 mRNA CTD PMID:17034753 NCBI chr 2:172,099,438...172,102,900
Ensembl chr 2:172,099,438...172,102,900 		JBrowse link
G DLX4 distal-less homeobox 4 increases expression EXP apocarotenal results in increased expression of DLX4 mRNA CTD PMID:17034753 NCBI chr17:49,968,572...49,974,959
Ensembl chr17:49,968,588...49,974,959 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression EXP apocarotenal results in decreased expression of ERCC2 mRNA CTD PMID:17034753 NCBI chr19:45,349,837...45,370,573
Ensembl chr19:45,349,837...45,370,918 		JBrowse link
G ETS1 ETS proto-oncogene 1, transcription factor decreases expression EXP apocarotenal results in decreased expression of ETS1 mRNA CTD PMID:17034753 NCBI chr11:128,458,765...128,587,558
Ensembl chr11:128,458,761...128,587,558 		JBrowse link
G FAS Fas cell surface death receptor increases expression EXP apocarotenal results in increased expression of FAS mRNA CTD PMID:17034753 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASN fatty acid synthase decreases expression EXP apocarotenal results in decreased expression of FASN mRNA CTD PMID:17034753 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G GATA6 GATA binding protein 6 increases expression EXP apocarotenal results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528 		JBrowse link
G GBP1 guanylate binding protein 1 increases expression EXP apocarotenal results in increased expression of GBP1 mRNA CTD PMID:17034753 NCBI chr 1:89,052,319...89,065,208
Ensembl chr 1:89,051,882...89,065,360 		JBrowse link
G GJA9 gap junction protein alpha 9 increases expression EXP apocarotenal results in increased expression of GJA9 mRNA CTD PMID:17034753 NCBI chr 1:38,874,069...38,881,587
Ensembl chr 1:38,874,069...38,881,587 		JBrowse link
G GSTK1 glutathione S-transferase kappa 1 decreases expression EXP apocarotenal results in decreased expression of GSTK1 mRNA CTD PMID:17034753 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854 		JBrowse link
G GSTM2 glutathione S-transferase mu 2 decreases expression EXP apocarotenal results in decreased expression of GSTM2 mRNA CTD PMID:17034753 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551 		JBrowse link
G GSTM4 glutathione S-transferase mu 4 decreases expression EXP apocarotenal results in decreased expression of GSTM4 mRNA CTD PMID:17034753 NCBI chr 1:109,656,099...109,667,727
Ensembl chr 1:109,656,099...109,665,496 		JBrowse link
G GSTM5 glutathione S-transferase mu 5 increases expression EXP apocarotenal results in increased expression of GSTM5 mRNA CTD PMID:17034753 NCBI chr 1:109,711,751...109,718,268
Ensembl chr 1:109,711,780...109,775,428 		JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 decreases expression EXP apocarotenal results in decreased expression of GSTZ1 mRNA CTD PMID:17034753 NCBI chr14:77,321,036...77,331,597
Ensembl chr14:77,320,996...77,331,597 		JBrowse link
G HOXA7 homeobox A7 increases expression EXP apocarotenal results in increased expression of HOXA7 mRNA CTD PMID:17034753 NCBI chr 7:27,153,716...27,156,675
Ensembl chr 7:27,153,716...27,157,936 		JBrowse link
G HOXB6 homeobox B6 increases expression EXP apocarotenal results in increased expression of HOXB6 mRNA CTD PMID:17034753 NCBI chr17:48,595,751...48,604,986
Ensembl chr17:48,595,751...48,604,992 		JBrowse link
G HOXC10 homeobox C10 increases expression EXP apocarotenal results in increased expression of HOXC10 mRNA CTD PMID:17034753 NCBI chr12:53,985,146...53,990,279
Ensembl chr12:53,985,065...53,990,279 		JBrowse link
G IFNA14 interferon alpha 14 increases expression EXP apocarotenal results in increased expression of IFNA14 mRNA CTD PMID:17034753 NCBI chr 9:21,239,002...21,240,005
Ensembl chr 9:21,239,002...21,240,005 		JBrowse link
G IFNA16 interferon alpha 16 increases expression EXP apocarotenal results in increased expression of IFNA16 mRNA CTD PMID:17034753 NCBI chr 9:21,216,373...21,217,311
Ensembl chr 9:21,216,373...21,217,311 		JBrowse link
G IFNA17 interferon alpha 17 increases expression EXP apocarotenal results in increased expression of IFNA17 mRNA CTD PMID:17034753 NCBI chr 9:21,227,243...21,228,222
Ensembl chr 9:21,227,243...21,228,222 		JBrowse link
G IFNA5 interferon alpha 5 increases expression EXP apocarotenal results in increased expression of IFNA5 mRNA CTD PMID:17034753 NCBI chr 9:21,304,326...21,305,313
Ensembl chr 9:21,304,326...21,305,313 		JBrowse link
G IRF8 interferon regulatory factor 8 increases expression EXP apocarotenal results in increased expression of IRF8 mRNA CTD PMID:17034753 NCBI chr16:85,899,162...85,922,609
Ensembl chr16:85,899,116...85,922,606 		JBrowse link
G IRX4 iroquois homeobox 4 decreases expression EXP apocarotenal results in decreased expression of IRX4 mRNA CTD PMID:17034753 NCBI chr 5:1,877,413...1,887,179
Ensembl chr 5:1,877,413...1,887,236 		JBrowse link
G ITGB4 integrin subunit beta 4 decreases expression EXP apocarotenal results in decreased expression of ITGB4 mRNA CTD PMID:17034753 NCBI chr17:75,721,459...75,757,818
Ensembl chr17:75,721,328...75,757,818 		JBrowse link
G IVL involucrin increases expression EXP apocarotenal results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 1:152,908,546...152,911,886
Ensembl chr 1:152,908,546...152,911,886 		JBrowse link
G KRT17 keratin 17 decreases expression EXP apocarotenal results in decreased expression of KRT17 mRNA CTD PMID:17034753 NCBI chr17:41,619,442...41,624,575
Ensembl chr17:41,619,442...41,624,842 		JBrowse link
G KRT2 keratin 2 increases expression EXP apocarotenal results in increased expression of KRT2 mRNA CTD PMID:17034753 NCBI chr12:52,644,558...52,652,211
Ensembl chr12:52,644,558...52,652,211 		JBrowse link
G KRT7 keratin 7 affects expression EXP apocarotenal affects the expression of KRT7 mRNA CTD PMID:17034753 NCBI chr12:52,233,243...52,255,853
Ensembl chr12:52,232,520...52,252,186 		JBrowse link
G LHX3 LIM homeobox 3 increases expression EXP apocarotenal results in increased expression of LHX3 mRNA CTD PMID:17034753 NCBI chr 9:136,196,250...136,205,128
Ensembl chr 9:136,196,250...136,205,128 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member affects expression EXP apocarotenal affects the expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738 		JBrowse link
G MEIS2 Meis homeobox 2 increases expression EXP apocarotenal results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr15:36,889,204...37,101,311
Ensembl chr15:36,889,204...37,101,299 		JBrowse link
G MEOX1 mesenchyme homeobox 1 increases expression EXP apocarotenal results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr17:43,640,389...43,661,922
Ensembl chr17:43,640,389...43,661,922 		JBrowse link
G MNX1 motor neuron and pancreas homeobox 1 increases expression EXP apocarotenal results in increased expression of MNX1 mRNA CTD PMID:17034753 NCBI chr 7:157,004,854...157,010,663
Ensembl chr 7:156,994,051...157,010,663 		JBrowse link
G MSH5 mutS homolog 5 increases expression EXP apocarotenal results in increased expression of MSH5 mRNA CTD PMID:17034753 NCBI chr 6:31,740,005...31,762,676
Ensembl chr 6:31,739,677...31,762,676 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming increases expression EXP apocarotenal results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138 		JBrowse link
G NOS1 nitric oxide synthase 1 increases expression EXP apocarotenal results in increased expression of NOS1 mRNA CTD PMID:17034753 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170 		JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 increases expression EXP apocarotenal results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138 		JBrowse link
G PCDHGC3 protocadherin gamma subfamily C, 3 increases expression EXP apocarotenal results in increased expression of PCDHGC3 mRNA CTD PMID:17034753 NCBI chr 5:141,475,966...141,512,975
Ensembl chr 5:141,475,947...141,512,977 		JBrowse link
G PLAAT4 phospholipase A and acyltransferase 4 decreases expression EXP apocarotenal results in decreased expression of PLAAT4 mRNA CTD PMID:17034753 NCBI chr11:63,536,808...63,546,458
Ensembl chr11:63,536,808...63,548,808 		JBrowse link
G PLSCR1 phospholipid scramblase 1 increases expression EXP apocarotenal results in increased expression of PLSCR1 mRNA CTD PMID:17034753 NCBI chr 3:146,515,180...146,544,607
Ensembl chr 3:146,515,180...146,544,856 		JBrowse link
G PLSCR3 phospholipid scramblase 3 increases expression EXP apocarotenal results in increased expression of PLSCR3 mRNA CTD PMID:17034753 NCBI chr17:7,389,727...7,394,525
Ensembl chr17:7,389,727...7,394,842 		JBrowse link
G PLSCR4 phospholipid scramblase 4 increases expression EXP apocarotenal results in increased expression of PLSCR4 mRNA CTD PMID:17034753 NCBI chr 3:146,192,335...146,251,105
Ensembl chr 3:146,192,335...146,251,179 		JBrowse link
G RAD51AP1 RAD51 associated protein 1 increases expression EXP apocarotenal results in increased expression of RAD51AP1 mRNA CTD PMID:17034753 NCBI chr12:4,538,890...4,560,047
Ensembl chr12:4,538,798...4,560,047 		JBrowse link
G RAD51D RAD51 paralog D increases expression EXP apocarotenal results in increased expression of RAD51D mRNA CTD PMID:17034753 NCBI chr17:35,092,221...35,119,860
Ensembl chr17:35,092,221...35,121,522 		JBrowse link
G RARA retinoic acid receptor alpha decreases expression EXP apocarotenal results in decreased expression of RARA mRNA CTD PMID:17034753 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643 		JBrowse link
G RARB retinoic acid receptor beta increases expression EXP apocarotenal results in increased expression of RARB mRNA CTD PMID:17034753 NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:24,687,887...25,597,932 		JBrowse link
G RARRES1 retinoic acid receptor responder 1 increases expression EXP apocarotenal results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 3:158,696,892...158,732,457
Ensembl chr 3:158,696,892...158,732,489 		JBrowse link
G SIX6 SIX homeobox 6 increases expression EXP apocarotenal results in increased expression of SIX6 mRNA CTD PMID:17034753 NCBI chr14:60,509,146...60,512,850
Ensembl chr14:60,509,146...60,512,850 		JBrowse link
G SOD1 superoxide dismutase 1 decreases expression EXP apocarotenal results in decreased expression of SOD1 mRNA CTD PMID:17034753 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SPTLC2 serine palmitoyltransferase long chain base subunit 2 affects expression EXP apocarotenal affects the expression of SPTLC2 mRNA CTD PMID:17034753 NCBI chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,637 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 increases expression EXP apocarotenal results in increased expression of SREBF1 mRNA CTD PMID:17034753 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G TGM4 transglutaminase 4 increases expression EXP apocarotenal results in increased expression of TGM4 mRNA CTD PMID:17034753 NCBI chr 3:44,874,608...44,914,990
Ensembl chr 3:44,874,608...44,914,990 		JBrowse link
G TNFRSF9 TNF receptor superfamily member 9 increases expression EXP apocarotenal results in increased expression of TNFRSF9 mRNA CTD PMID:17034753 NCBI chr 1:7,915,871...7,940,839
Ensembl chr 1:7,915,871...7,943,165 		JBrowse link
G TNFSF10 TNF superfamily member 10 increases expression EXP apocarotenal results in increased expression of TNFSF10 mRNA CTD PMID:17034753 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TXNDC9 thioredoxin domain containing 9 increases expression EXP apocarotenal results in increased expression of TXNDC9 mRNA CTD PMID:17034753 NCBI chr 2:99,306,184...99,336,333
Ensembl chr 2:99,318,982...99,340,702 		JBrowse link
G XRCC3 X-ray repair cross complementing 3 increases expression EXP apocarotenal results in increased expression of XRCC3 mRNA CTD PMID:17034753 NCBI chr14:103,697,617...103,715,451
Ensembl chr14:103,697,609...103,715,504 		JBrowse link
alpha-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNA15 G protein subunit alpha 15 increases response to substance
multiple interactions		 EXP GNA15 protein results in increased susceptibility to alpha-ionone
[GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OR1A1B protein		 CTD PMID:15598656 NCBI chr19:3,136,033...3,163,749
Ensembl chr19:3,136,033...3,163,749 		JBrowse link
G OR1A1 olfactory receptor family 1 subfamily A member 1 multiple interactions EXP [GNA15 protein results in increased susceptibility to alpha-ionone] which results in increased activity of OR1A1B protein CTD PMID:15598656 NCBI chr17:3,207,667...3,218,896
Ensembl chr17:3,207,539...3,218,896 		JBrowse link
G OR51E2 olfactory receptor family 51 subfamily E member 2 decreases activity EXP alpha-ionone results in decreased activity of OR51E2 protein CTD PMID:27226631 NCBI chr11:4,680,171...4,697,853
Ensembl chr11:4,680,171...4,697,854 		JBrowse link
beta-damascenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALML5 calmodulin like 5 increases expression ISO beta-damascenone results in increased expression of CALM4 mRNA CTD PMID:22982537 NCBI chr10:5,498,697...5,499,570
Ensembl chr10:5,498,697...5,499,570 		JBrowse link
G CASP14 caspase 14 increases expression
affects localization		 ISO beta-damascenone results in increased expression of CASP14 mRNA
beta-damascenone affects the localization of CASP14 protein		 CTD PMID:22982537 NCBI chr19:15,049,480...15,058,293
Ensembl chr19:15,049,480...15,058,293 		JBrowse link
G CES3 carboxylesterase 3 increases expression ISO beta-damascenone results in increased expression of CES3 mRNA CTD PMID:22982537 NCBI chr16:66,961,266...66,975,149
Ensembl chr16:66,961,245...66,975,149 		JBrowse link
G CLCA1 chloride channel accessory 1 increases expression ISO beta-damascenone results in increased expression of CLCA1 mRNA CTD PMID:22982537 NCBI chr 1:86,468,927...86,500,259
Ensembl chr 1:86,468,368...86,500,259 		JBrowse link
G CLCA2 chloride channel accessory 2 increases expression ISO beta-damascenone results in increased expression of CLCA2 mRNA CTD PMID:22982537 NCBI chr 1:86,424,171...86,456,553
Ensembl chr 1:86,424,171...86,456,553 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 increases expression ISO beta-damascenone results in increased expression of CYP17A1 mRNA CTD PMID:22982537 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472 		JBrowse link
G FCGBP Fc gamma binding protein increases expression ISO beta-damascenone results in increased expression of FCGBP mRNA CTD PMID:22982537 NCBI chr19:39,863,323...39,934,634
Ensembl chr19:39,863,323...39,934,626 		JBrowse link
G FLG filaggrin increases expression ISO beta-damascenone results in increased expression of FLG mRNA; beta-damascenone results in increased expression of FLG protein CTD PMID:22982537 NCBI chr 1:152,302,165...152,325,239
Ensembl chr 1:152,302,165...152,325,239 		JBrowse link
G HRNR hornerin increases expression ISO beta-damascenone results in increased expression of HRNR mRNA CTD PMID:22982537 NCBI chr 1:152,212,076...152,224,193
Ensembl chr 1:152,212,076...152,224,193 		JBrowse link
G IL20RA interleukin 20 receptor subunit alpha increases expression ISO beta-damascenone results in increased expression of IL20RA mRNA CTD PMID:22982537 NCBI chr 6:136,999,971...137,044,965
Ensembl chr 6:136,999,971...137,045,180 		JBrowse link
G IL36RN interleukin 36 receptor antagonist increases expression ISO beta-damascenone results in increased expression of IL36RN mRNA CTD PMID:22982537 NCBI chr 2:113,058,638...113,064,744
Ensembl chr 2:113,058,638...113,065,382 		JBrowse link
G KRT1 keratin 1 increases expression ISO beta-damascenone results in increased expression of KRT1 mRNA CTD PMID:22982537 NCBI chr12:52,674,736...52,680,407
Ensembl chr12:52,674,736...52,680,407 		JBrowse link
G KRT10 keratin 10 increases expression ISO beta-damascenone results in increased expression of KRT10 mRNA CTD PMID:22982537 NCBI chr17:40,818,117...40,822,614
Ensembl chr17:40,818,117...40,822,614 		JBrowse link
G LCE1B late cornified envelope 1B increases expression ISO beta-damascenone results in increased expression of LCE1B mRNA CTD PMID:22982537 NCBI chr 1:152,811,971...152,813,108
Ensembl chr 1:152,811,971...152,813,108 		JBrowse link
G LCE1C late cornified envelope 1C increases expression ISO beta-damascenone results in increased expression of LCE1C mRNA CTD PMID:22982537 NCBI chr 1:152,804,832...152,806,651
Ensembl chr 1:152,804,832...152,806,651 		JBrowse link
G LCE1D late cornified envelope 1D increases expression ISO beta-damascenone results in increased expression of LCE1D mRNA CTD PMID:22982537 NCBI chr 1:152,796,721...152,798,181
Ensembl chr 1:152,796,721...152,798,181 		JBrowse link
G LCE1F late cornified envelope 1F increases expression ISO beta-damascenone results in increased expression of LCE1F mRNA CTD PMID:22982537 NCBI chr 1:152,775,140...152,777,024
Ensembl chr 1:152,775,140...152,777,024 		JBrowse link
G LIPM lipase family member M increases expression ISO beta-damascenone results in increased expression of LIPM mRNA CTD PMID:22982537 NCBI chr10:88,802,730...88,820,546
Ensembl chr10:88,802,730...88,820,546 		JBrowse link
G LORICRIN loricrin cornified envelope precursor protein increases expression ISO beta-damascenone results in increased expression of LORICRIN mRNA CTD PMID:22982537 NCBI chr 1:153,259,687...153,262,124
Ensembl chr 1:153,259,687...153,262,124 		JBrowse link
G OTOP3 otopetrin 3 increases expression ISO beta-damascenone results in increased expression of OTOP3 mRNA CTD PMID:22982537 NCBI chr17:74,935,802...74,949,992
Ensembl chr17:74,935,898...74,949,992 		JBrowse link
G PLA2G4F phospholipase A2 group IVF increases expression ISO beta-damascenone results in increased expression of PLA2G4F mRNA CTD PMID:22982537 NCBI chr15:42,139,034...42,156,636
Ensembl chr15:42,139,034...42,156,636 		JBrowse link
G PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 increases expression ISO beta-damascenone results in increased expression of PLCXD1 mRNA CTD PMID:22982537 NCBI chr  X:276,356...303,356
NCBI chr  Y:276,356...303,356
Ensembl chr  Y:276,322...303,356
Ensembl chr  X:276,322...303,356 		JBrowse link
G SDR16C5 short chain dehydrogenase/reductase family 16C member 5 increases expression ISO beta-damascenone results in increased expression of SDR16C5 mRNA CTD PMID:22982537 NCBI chr 8:56,300,005...56,320,175
Ensembl chr 8:56,300,005...56,320,776 		JBrowse link
G SUSD2 sushi domain containing 2 increases expression ISO beta-damascenone results in increased expression of SUSD2 mRNA CTD PMID:22982537 NCBI chr22:24,181,487...24,189,106
Ensembl chr22:24,181,487...24,189,106 		JBrowse link
G TMPRSS4 transmembrane serine protease 4 increases expression ISO beta-damascenone results in increased expression of TMPRSS4 mRNA CTD PMID:22982537 NCBI chr11:118,077,078...118,125,505
Ensembl chr11:118,077,012...118,125,510 		JBrowse link
beta-ionone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP beta-ionone results in increased expression of BAX protein CTD PMID:31506784 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP beta-ionone results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; Hydroxychloroquine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; STK11 protein affects the reaction [beta-ionone results in decreased expression of BCL2 protein]		 CTD PMID:23100158 PMID:31506784 PMID:36843289 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
increases expression		 EXP [alpha-Tocopherol co-treated with beta-ionone] results in increased activity of CASP3 protein
beta-ionone results in increased cleavage of CASP3 protein
beta-ionone results in increased expression of CASP3 protein modified form		 CTD PMID:17618090 PMID:23100158 PMID:31506784 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 increases cleavage EXP beta-ionone results in increased cleavage of CASP9 protein CTD PMID:36843289 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP beta-ionone results in decreased expression of CCND1 protein CTD PMID:15450939 PMID:31506784 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP beta-ionone results in decreased expression of CDK2 protein CTD PMID:15450939 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP beta-ionone results in decreased expression of CDK4 protein CTD PMID:15450939 PMID:31506784 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G CRYZ crystallin zeta increases activity ISO beta-ionone results in increased activity of CRYZ protein CTD PMID:31506784 NCBI chr 1:74,705,486...74,733,050
Ensembl chr 1:74,705,482...74,733,408 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO beta-ionone promotes the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of HMGCR mRNA] CTD PMID:20435455 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G LMNB1 lamin B1 decreases farnesylation EXP beta-ionone results in decreased farnesylation of LMNB1 protein CTD PMID:10203554 NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions EXP 3-methyladenine inhibits the reaction [beta-ionone results in increased expression of and results in increased lipidation of MAP1LC3B protein]; beta-ionone results in increased expression of and results in increased lipidation of MAP1LC3B protein; STK11 protein affects the reaction [beta-ionone results in increased lipidation of MAP1LC3B protein] CTD PMID:36843289 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP
ISO		 beta-ionone results in increased phosphorylation of MAPK1 protein
beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK1 protein modified form]		 CTD PMID:23268108 PMID:27226631 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 protein modified form]
beta-ionone results in increased phosphorylation of MAPK3 protein		 CTD PMID:23268108 PMID:27226631 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:23268108 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:23268108 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G OR51E2 olfactory receptor family 51 subfamily E member 2 multiple interactions EXP beta-ionone binds to and results in increased activity of OR51E2 protein CTD PMID:27226631 NCBI chr11:4,680,171...4,697,853
Ensembl chr11:4,680,171...4,697,854 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 EXP 3-methyladenine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; Hydroxychloroquine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; STK11 protein affects the reaction [beta-ionone results in increased cleavage of PARP1 protein] CTD PMID:36843289 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP		 beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
beta-ionone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:23268108 PMID:31506784 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:23268108 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G STK11 serine/threonine kinase 11 multiple interactions
increases phosphorylation		 EXP STK11 protein affects the reaction [beta-ionone results in decreased expression of BCL2 protein]; STK11 protein affects the reaction [beta-ionone results in increased cleavage of PARP1 protein]; STK11 protein affects the reaction [beta-ionone results in increased lipidation of MAP1LC3B protein]
beta-ionone results in increased phosphorylation of STK11 protein		 CTD PMID:36843289 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO beta-ionone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; beta-ionone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:23268108 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TYR tyrosinase increases expression EXP beta-ionone results in increased expression of TYR mRNA; beta-ionone results in increased expression of TYR protein CTD PMID:27226631 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26503
    chemical entity 26483
      atom 26479
        nonmetal atom 25741
          carbon atom 25623
            organic molecular entity 25623
              isoprenoid 14726
                apo carotenoid 132
                  (3R)-3-hydroxy-10'-apo-beta-carotenal 0
                  (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal 0
                  10'-apo-beta-carotenal 0
                  13-apo-beta-carotenone 0
                  13-cis-10'-apo-lycopenal 0
                  2,6-dimethyldeca-2,4,6,8-tetraenedial 0
                  4,4'-diapolycopenedial 0
                  4,9-dimethyldodeca-2,4,6,8,10-pentaenedial 0
                  4-methylocta-2,4,6-trienedial 0
                  5-cis-10'-apo-lycopenal 0
                  6'-apo-beta-carotenal 0
                  9-cis-10'-apo-beta-carotenal 0
                  apo carotenoid C25 terpenoid + 0
                  apo carotenoid C35 terpenoid + 0
                  apo carotenoid diterpenoid + 0
                  apo carotenoid monoterpenoid + 49
                  apo carotenoid sesquiterpenoid + 1
                  apo carotenoid triterpenoid + 83
                  bixin dialdehyde 0
                  citranaxanthin 0
                  rosafluene 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26503
    subatomic particle 26479
      composite particle 26479
        hadron 26479
          baryon 26479
            nucleon 26479
              atomic nucleus 26479
                atom 26479
                  main group element atom 26216
                    main group molecular entity 26216
                      p-block molecular entity 26211
                        carbon group molecular entity 25661
                          organic molecular entity 25623
                            lipid 21398
                              isoprenoid 14726
                                apo carotenoid 132
                                  (3R)-3-hydroxy-10'-apo-beta-carotenal 0
                                  (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal 0
                                  10'-apo-beta-carotenal 0
                                  13-apo-beta-carotenone 0
                                  13-cis-10'-apo-lycopenal 0
                                  2,6-dimethyldeca-2,4,6,8-tetraenedial 0
                                  4,4'-diapolycopenedial 0
                                  4,9-dimethyldodeca-2,4,6,8,10-pentaenedial 0
                                  4-methylocta-2,4,6-trienedial 0
                                  5-cis-10'-apo-lycopenal 0
                                  6'-apo-beta-carotenal 0
                                  9-cis-10'-apo-beta-carotenal 0
                                  apo carotenoid C25 terpenoid + 0
                                  apo carotenoid C35 terpenoid + 0
                                  apo carotenoid diterpenoid + 0
                                  apo carotenoid monoterpenoid + 49
                                  apo carotenoid sesquiterpenoid + 1
                                  apo carotenoid triterpenoid + 83
                                  bixin dialdehyde 0
                                  citranaxanthin 0
                                  rosafluene 0
paths to the root