CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: nitrososulfamethoxazole
Accession: CHEBI:53017
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Definition: A sulfonamide compound having a 4-nitrosophenyl group attached to the sulfur atom and a 1,2-oxazol-3-yl group attached to the nitrogen atom.
Synonyms: exact_synonym: N-(5-methylisoxazol-3-yl)-4-nitrosobenzenesulfonamide
related_synonym: 4-Nitrososulfamethoxazole; Formula=C10H9N3O4S; InChI=1S/C10H9N3O4S/c1-7-6-10(12-17-7)13-18(15,16)9-4-2-8(11-14)3-5-9/h2-6H,1H3,(H,12,13); InChIKey=GHNQGDUYHCZZPT-UHFFFAOYSA-N; N-(5-Methyl-3-isoxazolyl)-4-nitrosobenzenesulfonamide; SMILES=Cc1cc(NS(=O)(=O)c2ccc(cc2)N=O)no1; SMX-NO; nitroso sulphamethoxazole
xref: Beilstein:6338308; CAS:131549-85-4
xref_mesh: MESH:C072956
xref: PMID:10217534; PMID:10843725; PMID:11153075; PMID:11350866; PMID:12181439; PMID:12676884; PMID:15588915; PMID:15664433; PMID:16473451; PMID:17442935; PMID:18334600; PMID:19358516; PMID:20221587; PMID:22342371; PMID:25851465; PMID:9262343; Reaxys:6338308
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
4-nitrososulfamethoxazole results in increased expression of AKR1B10 mRNA
CTD
PMID:28444390
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Hmgb1
high mobility group box 1
increases secretion
ISO
4-nitrososulfamethoxazole results in increased secretion of HMGB1 protein
CTD
PMID:28444390
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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Ifng
interferon gamma
increases secretion
ISO
4-nitrososulfamethoxazole results in increased secretion of IFNG protein
CTD
PMID:22331489
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il13
interleukin 13
increases secretion
ISO
4-nitrososulfamethoxazole results in increased secretion of IL13 protein
CTD
PMID:22331489
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il1a
interleukin 1 alpha
increases secretion
ISO
4-nitrososulfamethoxazole results in increased secretion of IL1A protein
CTD
PMID:28444390
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
increases secretion
ISO
4-nitrososulfamethoxazole results in increased secretion of IL1B protein
CTD
PMID:28444390
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il5
interleukin 5
increases secretion
ISO
4-nitrososulfamethoxazole results in increased secretion of IL5 protein
CTD
PMID:22331489
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Il6
interleukin 6
increases secretion
ISO
4-nitrososulfamethoxazole results in increased secretion of IL6 protein
CTD
PMID:28444390
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mpo
myeloperoxidase
affects binding multiple interactions
ISO
4-nitrososulfamethoxazole binds to MPO protein [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole
CTD
PMID:25531135
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
4-nitrososulfamethoxazole results in increased expression of NQO1 mRNA
CTD
PMID:28444390
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Srxn1
sulfiredoxin 1
increases expression
ISO
4-nitrososulfamethoxazole results in increased expression of SRXN1 mRNA
CTD
PMID:28444390
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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Tnf
tumor necrosis factor
increases secretion
ISO
4-nitrososulfamethoxazole results in increased secretion of TNF protein
CTD
PMID:28444390
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
4-nitrososulfamethoxazole results in increased expression of TXNRD1 mRNA
CTD
PMID:28444390
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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