nickel sulfate - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	nickel sulfate	go back to main search page
Accession:	CHEBI:53001	browse the term
Definition:	A metal sulfate having nickel(2+) as the metal ion.
Synonyms:	exact_synonym:	nickel(2+) sulfate
	related_synonym:	Formula=NiO4S; InChI=1S/Ni.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2; InChIKey=LGQLOGILCSXPEA-UHFFFAOYSA-L; NiSO4; Nickel sulfate(1:1); Nickel sulphate; Nickel(II) sulfate (1:1); SMILES=[Ni++].[O-]S([O-])(=O)=O; nickel(II) sulfate
	xref:	CAS:7786-81-4; Gmelin:8299
	xref_mesh:	MESH:C029938
	xref:	PMID:10444249; PMID:10444250; PMID:10469300; PMID:10975816; PMID:11207315; PMID:11851891; PMID:14634084; PMID:1694310; PMID:18837732; PMID:2026136; PMID:21616561; PMID:2415590; PMID:2477914; PMID:25042713; PMID:25097477; PMID:7615984; PMID:7687268; PMID:8566016; PMID:8891004; PMID:8991630; Reaxys:11329960; Wikipedia:Nickel(II)_sulfate

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Genes (1583)

nickel sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate-semialdehyde synthase

decreases expression

nickel sulfate results in decreased expression of AASS mRNA

NCBI chr 4:51,606,461...51,663,136
Ensembl chr 4:51,606,462...51,663,136

G

ATP binding cassette subfamily A member 5

increases expression

nickel sulfate results in increased expression of ABCA5 mRNA

NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976

G

ATP binding cassette subfamily A member 6

decreases expression

nickel sulfate results in decreased expression of ABCA6 mRNA

PMID:16780908 PMID:17374397

NCBI chr10:95,142,805...95,212,087
Ensembl chr10:95,142,966...95,211,530

G

ATP binding cassette subfamily C member 1

increases expression

nickel sulfate results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 3

increases expression

nickel sulfate results in increased expression of ABCC3 mRNA

PMID:16314067 PMID:22714537

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

abhydrolase domain containing 10, depalmitoylase

decreases expression

nickel sulfate results in decreased expression of ABHD10 mRNA

NCBI chr11:55,081,273...55,095,044
Ensembl chr11:55,081,049...55,107,866

G

abhydrolase domain containing 12, lysophospholipase

decreases expression

nickel sulfate results in decreased expression of ABHD12 mRNA

NCBI chr 3:139,659,315...139,719,529
Ensembl chr 3:139,659,317...139,719,564

G

abhydrolase domain containing 17A, depalmitoylase

increases expression

nickel sulfate results in increased expression of ABHD17A mRNA

NCBI chr 7:9,124,332...9,132,762
Ensembl chr 7:9,124,332...9,130,762

G

ABI family member 3 binding protein

increases expression

nickel sulfate results in increased expression of ABI3BP mRNA

NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929

G

actin-binding LIM protein 1

decreases expression

nickel sulfate results in decreased expression of ABLIM1 mRNA

NCBI chr 1:256,083,747...256,372,075
Ensembl chr 1:256,084,297...256,371,969

G

abraxas 1, BRCA1 A complex subunit

decreases expression

nickel sulfate results in decreased expression of ABRAXAS1 mRNA

NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622

G

acyl-CoA binding domain containing 7

decreases expression

nickel sulfate results in decreased expression of ACBD7 mRNA

NCBI chr17:74,903,936...74,909,977
Ensembl chr17:74,903,177...74,905,811

G

aconitase 1

decreases expression

nickel sulfate results in decreased expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

increases expression

nickel sulfate results in increased expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA thioesterase 13

increases expression

nickel sulfate results in increased expression of ACOT13 mRNA

NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851

G

acyl-CoA thioesterase 2

increases expression

nickel sulfate results in increased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA thioesterase 4

decreases expression

nickel sulfate results in decreased expression of ACOT4 mRNA

NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917

G

acyl-CoA oxidase 2

increases expression

nickel sulfate results in increased expression of ACOX2 mRNA

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

G

acyl-CoA synthetase long-chain family member 5

decreases expression

nickel sulfate results in decreased expression of ACSL5 mRNA

NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607

G

acyl-CoA synthetase short-chain family member 2

increases expression

nickel sulfate results in increased expression of ACSS2 mRNA

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

G

actin, alpha 1, skeletal muscle

increases expression

nickel sulfate results in increased expression of ACTA1 mRNA

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin, alpha, cardiac muscle 1

decreases expression

nickel sulfate results in decreased expression of ACTC1 mRNA

NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523

G

actin gamma 2, smooth muscle

increases expression

nickel sulfate results in increased expression of ACTG2 mRNA

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

activin A receptor type 1

increases expression

nickel sulfate results in increased expression of ACVR1 mRNA

NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241

G

activin A receptor type 1B

increases expression

nickel sulfate results in increased expression of ACVR1B mRNA

NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673

G

adenosine deaminase

increases expression

nickel sulfate results in increased expression of ADA mRNA

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

ADAM metallopeptidase domain 12

decreases expression

nickel sulfate results in decreased expression of ADAM12 mRNA

NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667

G

ADAM metallopeptidase domain 19

decreases expression

nickel sulfate results in decreased expression of ADAM19 mRNA

NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105

G

ADAM metallopeptidase domain 32

decreases expression

nickel sulfate results in decreased expression of ADAM32 mRNA

NCBI chr16:67,102,384...67,212,163
Ensembl chr16:67,102,320...67,212,161

G

ADAM metallopeptidase domain 8

increases expression

nickel sulfate results in increased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

decreases expression

nickel sulfate results in decreased expression of ADAMTS12 mRNA

NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629

G

ADAM metallopeptidase with thrombospondin type 1, motif 3

decreases expression

nickel sulfate results in decreased expression of ADAMTS3 mRNA

NCBI chr14:18,231,128...18,437,771
Ensembl chr14:18,231,165...18,435,556

G

ADAMTS-like 1

decreases expression

nickel sulfate results in decreased expression of ADAMTSL1 mRNA

NCBI chr 5:99,964,406...100,919,786
Ensembl chr 5:99,964,486...100,918,384

G

ADAMTS-like 3

decreases expression

nickel sulfate results in decreased expression of ADAMTSL3 mRNA

NCBI chr 1:136,288,793...136,596,986
Ensembl chr 1:136,288,793...136,596,986

G

aarF domain containing kinase 2

increases expression

nickel sulfate results in increased expression of ADCK2 mRNA

NCBI chr 4:68,348,853...68,362,725
Ensembl chr 4:68,348,864...68,374,608

G

adenylate cyclase 7

decreases expression

nickel sulfate results in decreased expression of ADCY7 mRNA

NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311

G

adducin 3

decreases expression

nickel sulfate results in decreased expression of ADD3 mRNA

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

G

adhesion G protein-coupled receptor G1

increases expression

nickel sulfate results in increased expression of ADGRG1 mRNA

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

G

adrenomedullin

increases expression
decreases expression

nickel sulfate results in increased expression of ADM mRNA
nickel sulfate results in decreased expression of ADM mRNA

PMID:18651567 PMID:22714537

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adenosine A2a receptor

increases expression

nickel sulfate results in increased expression of ADORA2A mRNA

PMID:16780908 PMID:22714537

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adenosine A2B receptor

increases expression

nickel sulfate results in increased expression of ADORA2B mRNA

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

G

actin filament associated protein 1-like 2

decreases expression

nickel sulfate results in decreased expression of AFAP1L2 mRNA

NCBI chr 1:255,964,238...256,060,828
Ensembl chr 1:255,964,238...256,060,820

G

ALF transcription elongation factor 3

increases expression

nickel sulfate results in increased expression of AFF3 mRNA

NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247

G

AGBL carboxypeptidase 5

increases expression

nickel sulfate results in increased expression of AGBL5 mRNA

NCBI chr 6:25,472,333...25,492,173
Ensembl chr 6:25,472,333...25,490,738

G

agmatinase

decreases expression

nickel sulfate results in decreased expression of AGMAT mRNA

NCBI chr 5:154,043,665...154,074,278
Ensembl chr 5:154,060,151...154,074,276

G

ATP/GTP binding carboxypeptidase 1

decreases expression

nickel sulfate results in decreased expression of AGTPBP1 mRNA

NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869

G

adenosylhomocysteinase-like 1

affects expression

nickel sulfate affects the expression of AHCYL1 mRNA

NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815

G

AT hook, DNA binding motif, containing 1

increases expression

nickel sulfate results in increased expression of AHDC1 mRNA

NCBI chr 5:145,228,228...145,294,170
Ensembl chr 5:145,228,227...145,294,145

G

AHNAK nucleoprotein 2

increases expression

nickel sulfate results in increased expression of AHNAK2 mRNA

NCBI chr 6:131,830,668...131,876,311

G

A-kinase anchoring protein 11

decreases expression

nickel sulfate results in decreased expression of AKAP11 mRNA

NCBI chr15:53,911,635...53,956,138
Ensembl chr15:53,911,657...53,941,605

G

aldo-keto reductase family 1 member B1

increases expression

nickel sulfate results in increased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

increases expression

nickel sulfate results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C1

increases expression

nickel sulfate results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C3

increases expression

nickel sulfate results in increased expression of AKR1C3 mRNA

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 1, member E2

decreases expression

nickel sulfate results in decreased expression of AKR1E2 mRNA

NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441

G

AKT serine/threonine kinase 1

increases phosphorylation

nickel sulfate results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

activated leukocyte cell adhesion molecule

increases expression

nickel sulfate results in increased expression of ALCAM mRNA

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

aldehyde dehydrogenase 1 family, member L2

decreases expression

nickel sulfate results in decreased expression of ALDH1L2 mRNA

NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776

G

aldehyde dehydrogenase 3 family, member A2

increases expression

nickel sulfate results in increased expression of ALDH3A2 mRNA

NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281

G

aldehyde dehydrogenase 5 family, member A1

increases expression

nickel sulfate results in increased expression of ALDH5A1 mRNA

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

aldolase, fructose-bisphosphate C

increases expression

nickel sulfate results in increased expression of ALDOC mRNA

PMID:17382205 PMID:22714537

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

ALG5, dolichyl-phosphate beta-glucosyltransferase

decreases expression

nickel sulfate results in decreased expression of ALG5 mRNA

NCBI chr 2:138,936,998...138,951,228
Ensembl chr 2:138,936,993...138,951,216

G

arachidonate 5-lipoxygenase activating protein

decreases expression

nickel sulfate results in decreased expression of ALOX5AP mRNA

NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986

G

alpha-kinase 2

decreases expression

nickel sulfate results in decreased expression of ALPK2 mRNA

NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258

G

Aly/REF export factor

increases expression

nickel sulfate results in increased expression of THOC4 mRNA

NCBI chr10:105,871,424...105,875,076
Ensembl chr10:105,871,306...105,875,069

G

adenosine monophosphate deaminase 3

affects expression

nickel sulfate affects the expression of AMPD3 mRNA

NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887

G

angiopoietin-like 4

multiple interactions
increases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of ANGPTL4 mRNA
nickel sulfate results in increased expression of ANGPTL4 mRNA

PMID:16166746 PMID:17382205 PMID:18832182

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

ANKH inorganic pyrophosphate transport regulator

increases expression

nickel sulfate results in increased expression of ANKH mRNA

NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187

G

ankyrin repeat domain 1

decreases expression

nickel sulfate results in decreased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

G

ankyrin repeat domain 6

increases expression

nickel sulfate results in increased expression of ANKRD6 mRNA

NCBI chr 5:47,197,981...47,343,183
Ensembl chr 5:47,202,873...47,343,090

G

anoctamin 2

decreases expression

nickel sulfate results in decreased expression of ANO2 mRNA

NCBI chr 4:158,514,200...158,855,639
Ensembl chr 4:158,496,014...158,855,651

G

alanyl aminopeptidase, membrane

decreases expression

nickel sulfate results in decreased expression of ANPEP mRNA

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

ANTXR cell adhesion molecule 1

increases expression

nickel sulfate results in increased expression of ANTXR1 mRNA

NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232

G

ANTXR cell adhesion molecule 2

increases expression
decreases expression

nickel sulfate results in increased expression of ANTXR2 mRNA
nickel sulfate results in decreased expression of ANTXR2 mRNA

PMID:16780908 PMID:22714537

NCBI chr14:11,541,718...11,682,110
Ensembl chr14:11,541,772...11,682,094

G

annexin A1

increases expression

nickel sulfate results in increased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A2

increases expression

nickel sulfate results in increased expression of ANXA2 mRNA

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

annexin A3

decreases expression

nickel sulfate results in decreased expression of ANXA3 mRNA

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

amine oxidase, copper containing 1

increases expression

nickel sulfate results in increased expression of AOC1 mRNA

NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840

G

aldehyde oxidase 1

decreases expression

nickel sulfate results in decreased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

adaptor-related protein complex 1 associated regulatory protein

decreases expression

nickel sulfate results in decreased expression of AP1AR mRNA

NCBI chr 2:216,276,631...216,309,020
Ensembl chr 2:216,276,631...216,309,013

G

amyloid beta precursor protein binding family A member 2

increases expression

nickel sulfate results in increased expression of APBA2 mRNA

NCBI chr 1:118,053,270...118,286,858
Ensembl chr 1:118,103,219...118,285,699

G

adipocyte plasma membrane associated protein

decreases expression

nickel sulfate results in decreased expression of APMAP mRNA

NCBI chr 3:139,409,021...139,437,296
Ensembl chr 3:139,409,022...139,437,341

G

apolipoprotein E

decreases expression
increases expression

nickel sulfate results in decreased expression of APOE mRNA
nickel sulfate results in increased expression of APOE mRNA

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

aquaporin 3 (Gill blood group)

decreases expression

nickel sulfate results in decreased expression of AQP3 mRNA

PMID:16780908 PMID:20713136

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

aquaporin 9

decreases expression

nickel sulfate results in decreased expression of AQP9 mRNA

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

androgen receptor

increases expression

nickel sulfate results in increased expression of AR mRNA

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

decreases expression

nickel sulfate results in decreased expression of ARAP2 mRNA

NCBI chr14:46,717,657...46,917,326
Ensembl chr14:46,718,760...46,917,154

G

amphiregulin

increases expression
decreases expression

nickel sulfate results in increased expression of AREG mRNA
nickel sulfate results in decreased expression of AREG mRNA

PMID:16166746 PMID:18651567 PMID:22714537

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

ADP-ribosylation factor interacting protein 2

increases expression

nickel sulfate results in increased expression of ARFIP2 mRNA

NCBI chr 1:159,974,255...159,980,398
Ensembl chr 1:159,974,201...159,980,336

G

arginase 2

increases expression

nickel sulfate results in increased expression of ARG2 mRNA

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

Rho GTPase activating protein 17

decreases expression

nickel sulfate results in decreased expression of ARHGAP17 mRNA

NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854

G

Rho GTPase activating protein 18

increases expression

nickel sulfate results in increased expression of ARHGAP18 mRNA

NCBI chr 1:18,403,531...18,637,306
Ensembl chr 1:18,403,537...18,637,256

G

Rho GTPase activating protein 42

decreases expression

nickel sulfate results in decreased expression of ARHGAP42 mRNA

NCBI chr 8:6,154,759...6,384,497
Ensembl chr 8:6,156,865...6,384,870

G

Rho GTPase activating protein 44

increases expression

nickel sulfate results in increased expression of ARHGAP44 mRNA

NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297

G

Rho GTPase activating protein 5

decreases expression

nickel sulfate results in decreased expression of ARHGAP5 mRNA

NCBI chr 6:69,975,904...70,039,299
Ensembl chr 6:69,976,214...70,037,660

G

Cdc42 guanine nucleotide exchange factor 9

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of ARHGEF9 mRNA

NCBI chr X:59,919,560...60,077,538
Ensembl chr X:59,920,870...60,077,513

G

ADP-ribosylation factor like GTPase 10

decreases expression

nickel sulfate results in decreased expression of ARL10 mRNA

NCBI chr17:10,030,213...10,038,625
Ensembl chr17:10,030,213...10,038,703

G

ADP ribosylation factor like GTPase 4C

increases expression

nickel sulfate results in increased expression of ARL4C mRNA

PMID:17374397 PMID:18651567

NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513

G

armadillo repeat containing, X-linked 1

decreases expression

nickel sulfate results in decreased expression of ARMCX1 mRNA

NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299

G

armadillo repeat containing, X-linked 2

decreases expression

nickel sulfate results in decreased expression of ARMCX2 mRNA

NCBI chr X:97,980,662...97,985,523
Ensembl chr X:97,980,660...97,985,552

G

armadillo repeat containing, X-linked 4

decreases expression

nickel sulfate results in decreased expression of ARMCX4 mRNA

NCBI chr X:97,860,526...97,870,912
Ensembl chr X:97,860,629...97,870,912

G

aryl hydrocarbon receptor nuclear translocator

affects localization

nickel sulfate affects the localization of ARNT protein

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

aryl hydrocarbon receptor nuclear translocator 2

increases expression

nickel sulfate results in increased expression of ARNT2 mRNA

NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153

G

actin related protein 2/3 complex, subunit 2

increases expression

nickel sulfate results in increased expression of ARPC2 mRNA

NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471

G

actin related protein 2/3 complex, subunit 4

increases expression

nickel sulfate results in increased expression of ARPC4 mRNA

NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785

G

arrestin, beta 1

increases expression

nickel sulfate results in increased expression of ARRB1 mRNA

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

N-acylsphingosine amidohydrolase 1

decreases expression

nickel sulfate results in decreased expression of ASAH1 mRNA

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

asialoglycoprotein receptor 1

decreases expression

nickel sulfate results in decreased expression of ASGR1 mRNA

NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631

G

asialoglycoprotein receptor 2

decreases expression

nickel sulfate results in decreased expression of ASGR2 mRNA

NCBI chr10:54,821,407...54,834,624
Ensembl chr10:54,821,438...54,834,617

G

acetylserotonin O-methyltransferase-like

increases expression

nickel sulfate results in increased expression of ASMTL mRNA

NCBI chr12:16,315,335...16,318,083
Ensembl chr12:16,315,414...16,318,080

G

argininosuccinate synthase 1

increases expression

nickel sulfate results in increased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

alpha tubulin acetyltransferase 1

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of ATAT1 mRNA

NCBI chr20:2,844,595...2,857,809
Ensembl chr20:2,844,616...2,861,964

G

activating transcription factor 3

increases expression

nickel sulfate results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 6

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

atlastin GTPase 1

decreases expression

nickel sulfate results in decreased expression of ATL1 mRNA

NCBI chr 6:88,377,168...88,475,242
Ensembl chr 6:88,377,239...88,475,204

G

atlastin GTPase 3

decreases expression

nickel sulfate results in decreased expression of ATL3 mRNA

NCBI chr 1:204,680,958...204,727,360
Ensembl chr 1:204,680,968...204,723,354

G

ATPase phospholipid transporting 11A

decreases expression

nickel sulfate results in decreased expression of ATP11A mRNA

NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640

G

ATPase Na+/K+ transporting subunit beta 1

decreases expression

nickel sulfate results in decreased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase Na+/K+ transporting subunit beta 3

increases expression
decreases expression

nickel sulfate results in increased expression of ATP1B3 mRNA
nickel sulfate results in decreased expression of ATP1B3 mRNA

PMID:16780908 PMID:18651567

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598

G

ATPase plasma membrane Ca2+ transporting 4

decreases expression

nickel sulfate results in decreased expression of ATP2B4 mRNA

NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246

G

ATPase H+ transporting V1 subunit A

decreases expression

nickel sulfate results in decreased expression of ATP6V1A mRNA

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase phospholipid transporting 8B2

decreases expression

nickel sulfate results in decreased expression of ATP8B2 mRNA

NCBI chr 2:175,378,514...175,402,265
Ensembl chr 2:175,378,517...175,401,883

G

ATPase phospholipid transporting 9A (putative)

increases expression

nickel sulfate results in increased expression of ATP9A mRNA

NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818

G

attractin

decreases expression

nickel sulfate results in decreased expression of ATRN mRNA

NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322

G

ataxin 1

increases expression

nickel sulfate results in increased expression of ATXN1 mRNA

NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360

G

ataxin 7-like 1

increases expression

nickel sulfate results in increased expression of ATXN7L1 mRNA

NCBI chr 6:49,759,876...49,982,323
Ensembl chr 6:49,759,883...49,982,320

G

activator of transcription and developmental regulator AUTS2

increases expression

nickel sulfate results in increased expression of AUTS2 mRNA

NCBI chr12:24,104,187...25,194,123
Ensembl chr12:24,104,192...25,194,416

G

antizyme inhibitor 1

decreases expression

nickel sulfate results in decreased expression of AZIN1 mRNA

NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578

G

beta-1,3-glucuronyltransferase 1

decreases expression

nickel sulfate results in decreased expression of B3GAT1 mRNA

NCBI chr 8:25,087,123...25,114,692
Ensembl chr 8:25,087,547...25,113,395

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

increases expression

nickel sulfate results in increased expression of B3GNT5 mRNA

NCBI chr11:81,141,102...81,153,206
Ensembl chr11:81,140,599...81,156,166

G

beta-1,4-N-acetyl-galactosaminyl transferase 1

increases expression

nickel sulfate results in increased expression of B4GALNT1 mRNA

NCBI chr 7:62,988,429...62,996,190
Ensembl chr 7:62,988,930...62,996,190

G

BTB domain and CNC homolog 1

increases expression

nickel sulfate results in increased expression of BACH1 mRNA

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

BAR/IMD domain containing adaptor protein 2 like 1

increases expression

nickel sulfate results in increased expression of BAIAP2L1 mRNA

NCBI chr12:10,250,434...10,339,937
Ensembl chr12:10,250,473...10,339,928

G

BCL2-antagonist/killer 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]
nickel sulfate results in increased expression of BAK1 mRNA; nickel sulfate results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BMP and activin membrane-bound inhibitor

increases expression

nickel sulfate results in increased expression of BAMBI mRNA

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

sesamin inhibits the reaction [nickel sulfate results in increased expression of BAX protein]
pyrazolanthrone inhibits the reaction [nickel sulfate results in increased expression of BAX protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of BAX protein]
nickel sulfate results in increased expression of BAX mRNA; nickel sulfate results in increased expression of BAX protein

PMID:23317420 PMID:35499276

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bardet-Biedl syndrome 5

increases expression

nickel sulfate results in increased expression of BBS5 mRNA

NCBI chr 3:54,410,429...54,431,831
Ensembl chr 3:54,410,775...54,431,829

G

BCAR1 scaffold protein, Cas family member

decreases expression

nickel sulfate results in decreased expression of BCAR1 mRNA

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

BCL11 transcription factor A

decreases expression

nickel sulfate results in decreased expression of BCL11A mRNA

NCBI chr14:98,029,018...98,124,181
Ensembl chr14:98,030,461...98,124,180

G

BCL2, apoptosis regulator

increases expression
decreases expression
multiple interactions

nickel sulfate results in increased expression of BCL2 protein
nickel sulfate results in decreased expression of BCL2 protein
sesamin inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]
nickel sulfate results in decreased expression of BCL2 mRNA; nickel sulfate results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]; Selenium inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]

PMID:21776270 PMID:23317420 PMID:34612572 PMID:35499276

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

increases expression

nickel sulfate results in increased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

increases expression
multiple interactions
decreases expression

nickel sulfate results in increased expression of BCL2L1 protein
pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of BCL2L1 protein]
nickel sulfate results in decreased expression of BCL2L1 mRNA; nickel sulfate results in decreased expression of BCL2L1 protein

PMID:21776270 PMID:35499276

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

Bcl2-like 11

increases expression

nickel sulfate results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

BCL9, transcription coactivator

increases expression

nickel sulfate results in increased expression of BCL9 mRNA

NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435

G

3-hydroxybutyrate dehydrogenase 1

decreases expression

nickel sulfate results in decreased expression of BDH1 mRNA

NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671

G

brain expressed X-linked 2

decreases expression

nickel sulfate results in decreased expression of BEX1 mRNA

NCBI chr X:99,019,847...99,021,375
Ensembl chr X:99,019,000...99,021,503

G

brain expressed, X-linked 4

decreases expression

nickel sulfate results in decreased expression of BEX4 mRNA

NCBI chr X:99,131,985...99,133,417
Ensembl chr X:99,131,942...99,133,531

G

basic helix-loop-helix family, member e40

increases expression

nickel sulfate results in increased expression of BHLHE40 mRNA

PMID:18651567 PMID:22714537

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

BicC family RNA binding protein 1

decreases expression

nickel sulfate results in decreased expression of BICC1 mRNA

NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776

G

BH3 interacting domain death agonist

increases expression

nickel sulfate results in increased expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

bridging integrator 1

increases expression

nickel sulfate results in increased expression of BIN1 mRNA

NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263

G

baculoviral IAP repeat-containing 2

increases expression

nickel sulfate results in increased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

increases expression

nickel sulfate results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

multiple interactions

nickel sulfate affects the localization of and results in increased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BMI1 proto-oncogene, polycomb ring finger

decreases expression

nickel sulfate results in decreased expression of BMI1 mRNA

NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690

G

bone morphogenetic protein 2

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 4

increases expression

nickel sulfate results in increased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

bone morphogenetic protein 6

increases expression

nickel sulfate results in increased expression of BMP6 mRNA

PMID:16780908 PMID:17374397

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

BMP-binding endothelial regulator

decreases expression

nickel sulfate results in decreased expression of BMPER mRNA

NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256

G

BCL2 interacting protein 3

increases expression

nickel sulfate results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BRCA1/BRCA2-containing complex subunit 3

decreases expression

nickel sulfate results in decreased expression of BRCC3 mRNA

NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080

G

bromodomain containing 2

decreases expression

nickel sulfate results in decreased expression of BRD2 mRNA

NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388

G

bone marrow stromal cell antigen 2

increases expression

nickel sulfate results in increased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

BTB domain containing 2

increases expression

nickel sulfate results in increased expression of BTBD2 mRNA

NCBI chr 7:9,058,609...9,075,341
Ensembl chr 7:9,060,788...9,075,344

G

BTB domain containing 3

decreases expression

nickel sulfate results in decreased expression of BTBD3 mRNA

NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038

G

BTG anti-proliferation factor 1

increases expression

nickel sulfate results in increased expression of BTG1 mRNA

PMID:16780908 PMID:17374397 PMID:22714537

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

nickel sulfate results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

similar to human chromosome 10 open reading frame 67

decreases expression

nickel sulfate results in decreased expression of C10ORF67 mRNA

NCBI chr17:82,062,461...82,174,401
Ensembl chr17:82,071,838...82,174,353

G

similar to human chromosome 1 open reading frame 198

increases expression

nickel sulfate results in increased expression of C1ORF198 mRNA

NCBI chr19:52,604,060...52,629,436
Ensembl chr19:52,604,060...52,629,436

G

similar to human chromosome 19 open reading frame 33

decreases expression

nickel sulfate results in decreased expression of C19ORF33 mRNA

NCBI chr 1:84,549,830...84,550,666
Ensembl chr 1:84,549,831...84,550,664

G

complement C1q A chain

decreases expression

nickel sulfate results in decreased expression of C1QA mRNA

NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534

G

complement C1q B chain

decreases expression

nickel sulfate results in decreased expression of C1QB mRNA

NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407

G

complement C1q C chain

decreases expression

nickel sulfate results in decreased expression of C1QC mRNA

NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017

G

complement C1q like 4

increases expression

nickel sulfate results in increased expression of C1QL4 mRNA

NCBI chr 7:130,243,606...130,246,678
Ensembl chr 7:130,243,606...130,246,678

G

complement C1r

increases expression

nickel sulfate results in increased expression of C1R mRNA

NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484

G

complement C1s

increases expression

nickel sulfate results in increased expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

G

similar to human chromosome 15 open reading frame 48

increases expression

nickel sulfate results in increased expression of C15ORF48 mRNA

NCBI chr 3:109,719,952...109,723,505
Ensembl chr 3:109,719,897...109,724,006
Ensembl chr 3:109,719,897...109,724,006

G

complement C5

affects expression
decreases expression

nickel sulfate affects the expression of HC mRNA
nickel sulfate results in decreased expression of HC mRNA

PMID:12718980 PMID:16166746

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

similar to human chromosome 6 open reading frame 132

decreases expression

nickel sulfate results in decreased expression of C6ORF132 mRNA

NCBI chr 9:13,524,822...13,561,756
Ensembl chr 9:13,525,395...13,561,585

G

Cdk5 and Abl enzyme substrate 1

increases expression

nickel sulfate results in increased expression of CABLES1 mRNA

NCBI chr18:3,076,556...3,181,181
Ensembl chr18:3,075,524...3,181,181

G

cache domain containing 1

increases expression

nickel sulfate results in increased expression of CACHD1 mRNA

NCBI chr 5:115,411,833...115,637,312
Ensembl chr 5:115,411,071...115,657,505

G

calcium voltage-gated channel subunit alpha1 I

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of CACNA1I mRNA

NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688

G

calcitonin receptor like receptor

increases expression

nickel sulfate results in increased expression of CALCRL mRNA

PMID:16780908 PMID:17374397

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

G

calcium/calmodulin-dependent protein kinase I

increases expression

nickel sulfate results in increased expression of CAMK1 mRNA

NCBI chr 4:146,481,196...146,492,039
Ensembl chr 4:146,481,196...146,492,081

G

calnexin

decreases expression

nickel sulfate results in decreased expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

caprin family member 2

increases expression

nickel sulfate results in increased expression of CAPRIN2 mRNA

NCBI chr 4:181,806,105...181,860,754
Ensembl chr 4:181,806,575...181,860,830

G

carbonic anhydrase 13

decreases expression

nickel sulfate results in decreased expression of CA13 mRNA

NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525

G

carbonic anhydrase 2

decreases expression

nickel sulfate results in decreased expression of CA2 mRNA

PMID:16780908 PMID:17374397

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 9

multiple interactions
increases expression
decreases expression

Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of CA9 protein]
nickel sulfate results in decreased expression of CA9 mRNA

PMID:16288478 PMID:22714537

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

caspase recruitment domain family, member 10

increases expression

nickel sulfate results in increased expression of CARD10 mRNA

NCBI chr 7:110,330,460...110,371,551
Ensembl chr 7:110,330,408...110,359,224

G

capping protein regulator and myosin 1 linker 1

increases expression

nickel sulfate results in increased expression of CARMIL1 mRNA

NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326

G

calcium/calmodulin dependent serine protein kinase

decreases expression

nickel sulfate results in decreased expression of CASK mRNA

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

G

caspase 12

increases expression
multiple interactions

nickel sulfate results in increased expression of CASP12 mRNA; nickel sulfate results in increased expression of CASP12 protein
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP12 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]

PMID:28296042 PMID:34612572

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases cleavage
increases expression
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]]; nickel sulfate inhibits the reaction [Potassium Dichromate results in increased cleavage of and results in increased activity of CASP3 protein]; nickel sulfate results in increased cleavage of and results in increased activity of CASP3 protein; nickel sulfate results in increased expression of and results in increased cleavage of CASP3 protein; Potassium Dichromate inhibits the reaction [nickel sulfate results in increased cleavage of and results in increased activity of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in decreased expression of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]
nickel sulfate results in increased cleavage of CASP3 protein
sesamin inhibits the reaction [nickel sulfate results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]
nickel sulfate results in increased expression of CASP3 protein; nickel sulfate results in increased expression of CASP3 protein modified form
nickel sulfate results in increased expression of CASP3 mRNA; nickel sulfate results in increased expression of CASP3 protein modified form

PMID:20493934 PMID:23317420 PMID:28296042 PMID:34612572 PMID:35499276

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP9 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]
nickel sulfate results in increased expression of CASP9 mRNA; nickel sulfate results in increased expression of CASP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]

PMID:28296042 PMID:34612572

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases expression
multiple interactions
decreases activity
increases activity

nickel sulfate results in increased expression of CAT mRNA
naringin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]; Selenium inhibits the reaction [nickel sulfate results in increased activity of CAT protein]; Zinc inhibits the reaction [nickel sulfate results in increased activity of CAT protein]
sesamin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]

PMID:15535990 PMID:20566472 PMID:20950607 PMID:23317420 PMID:34612572

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cbl proto-oncogene B

increases expression

nickel sulfate results in increased expression of CBLB mRNA

NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839

G

carbonyl reductase 2

decreases expression

nickel sulfate results in decreased expression of CBR2 mRNA

NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001

G

chromobox 2

increases expression

nickel sulfate results in increased expression of CBX2 mRNA

NCBI chr10:104,278,517...104,287,384
Ensembl chr10:104,278,549...104,287,383

G

coiled-coil domain containing 167

increases expression

nickel sulfate results in increased expression of CCDC167 mRNA

NCBI chr20:7,763,927...7,782,090
Ensembl chr20:7,751,782...7,781,613

G

coiled-coil domain containing 169

decreases expression

nickel sulfate results in decreased expression of CCDC169 mRNA

NCBI chr 2:139,321,644...139,351,161
Ensembl chr 2:139,321,670...139,351,161

G

coiled-coil domain containing 18

decreases expression

nickel sulfate results in decreased expression of CCDC18 mRNA

NCBI chr14:1,501,749...1,607,672
Ensembl chr14:1,501,784...1,607,711

G

coiled-coil domain containing 3

increases expression

nickel sulfate results in increased expression of CCDC3 mRNA

NCBI chr17:73,031,891...73,135,173
Ensembl chr17:73,035,045...73,135,337

G

coiled-coil domain containing 68

increases expression

nickel sulfate results in increased expression of CCDC68 mRNA

NCBI chr18:63,541,828...63,584,122
Ensembl chr18:63,541,896...63,584,119

G

coiled-coil domain containing 80

decreases expression

nickel sulfate results in decreased expression of CCDC80 mRNA

NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137

G

coiled-coil domain containing 88C

increases expression

nickel sulfate results in increased expression of CCDC88C mRNA

NCBI chr 6:120,169,752...120,289,459
Ensembl chr 6:120,169,738...120,289,555

G

C-C motif chemokine ligand 1

increases expression

nickel sulfate results in increased expression of CCL1 mRNA

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 11

decreases expression
affects expression
increases expression

nickel sulfate results in decreased expression of CCL11 mRNA
nickel sulfate affects the expression of CCL11 mRNA
nickel sulfate results in increased expression of CCL11 mRNA

PMID:16166746 PMID:18202158 PMID:18832182

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 12

decreases expression

nickel sulfate results in decreased expression of CCL13 mRNA

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

C-C motif chemokine ligand 17

affects expression
increases expression

nickel sulfate affects the expression of CCL17 mRNA
nickel sulfate results in increased expression of CCL17 mRNA

PMID:16166746 PMID:18202158

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 2

decreases expression
increases expression
multiple interactions

nickel sulfate results in decreased expression of CCL2 mRNA
nickel sulfate results in increased expression of CCL2 mRNA
[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of CCL2 mRNA

PMID:12060402 PMID:15585374 PMID:16100012 PMID:16166746 PMID:16780908 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

multiple interactions
increases secretion

IL1A protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]; TNF protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]

PMID:15679580 PMID:16099135

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 22

affects expression
increases expression

nickel sulfate affects the expression of CCL22 mRNA
nickel sulfate results in increased expression of CCL22 mRNA

PMID:12060402 PMID:16166746 PMID:18202158

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 27

increases secretion

nickel sulfate results in increased secretion of CCL27 protein

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

G

C-C motif chemokine ligand 28

decreases expression

nickel sulfate results in decreased expression of CCL28 mRNA

NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997

G

C-C motif chemokine ligand 3

affects expression
increases expression

nickel sulfate affects the expression of CCL3 mRNA
nickel sulfate results in increased expression of CCL3 mRNA

PMID:15585374 PMID:16780908 PMID:18202158 PMID:19732821

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

increases expression
increases secretion

nickel sulfate results in increased expression of CCL4 mRNA; nickel sulfate results in increased expression of CCL4 protein
nickel sulfate results in increased secretion of CCL4 protein

PMID:12060402 PMID:15585374 PMID:16314067 PMID:16780908 PMID:18353026 More...

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

affects expression
increases secretion

nickel sulfate affects the expression of CCL5 mRNA
nickel sulfate results in increased secretion of CCL5 protein

PMID:16099135 PMID:18202158

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

increases expression

nickel sulfate results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine receptor 1

affects expression

nickel sulfate affects the expression of CCR1 mRNA

NCBI chr 8:123,556,286...123,561,841

G

C-C motif chemokine receptor 2

decreases expression

nickel sulfate results in decreased expression of CCR2 mRNA

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 6

decreases expression

nickel sulfate results in decreased expression of CCR6 protein

NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603

G

C-C motif chemokine receptor 7

affects expression
increases expression

nickel sulfate affects the expression of CCR7 mRNA
nickel sulfate results in increased expression of CCR7 mRNA

PMID:15304089 PMID:16780908 PMID:17374397 PMID:18202158 PMID:21697260

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

C-C motif chemokine receptor 8

affects expression
increases expression

nickel sulfate affects the expression of CCR8 mRNA
nickel sulfate results in increased expression of CCR8 mRNA

PMID:11145678 PMID:18202158

NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629

G

Cd200 molecule

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CD200 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of CD200 mRNA

PMID:22714537 PMID:31734292

NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648

G

CD207 molecule

multiple interactions
decreases expression

pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CD207 protein]

NCBI chr 4:116,155,229...116,161,587
Ensembl chr 4:116,155,212...116,161,518

G

CD274 molecule

increases expression
decreases expression

nickel sulfate results in increased expression of CD274 protein
nickel sulfate results in decreased expression of CD274 mRNA

PMID:22714537 PMID:25673294

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

Cd276 molecule

increases expression

nickel sulfate results in increased expression of CD276 mRNA

NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380

G

CD36 molecule

decreases expression

nickel sulfate results in decreased expression of CD36 mRNA

PMID:16780908 PMID:17374397

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD40 molecule

multiple interactions
increases expression

BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD40 protein]

PMID:17636246 PMID:25673294

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

Cd68 molecule

increases expression

nickel sulfate results in increased expression of CD68 mRNA

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

Cd69 molecule

increases expression

nickel sulfate results in increased expression of CD69 mRNA

NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542

G

CD74 molecule

decreases expression

nickel sulfate results in decreased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

CD79a molecule

decreases expression

nickel sulfate results in decreased expression of CD79A mRNA

NCBI chr 1:80,493,581...80,497,936
Ensembl chr 1:80,493,581...80,497,935

G

Cd80 molecule

increases expression

nickel sulfate results in increased expression of CD80 protein

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

Cd82 molecule

increases expression

nickel sulfate results in increased expression of CD82 mRNA

NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809

G

CD83 molecule

increases expression
multiple interactions

nickel sulfate results in increased expression of CD83 mRNA; nickel sulfate results in increased expression of CD83 protein
BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD83 protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [nickel sulfate results in increased expression of CD83 protein]; TNF protein promotes the reaction [nickel sulfate results in increased expression of CD83 protein]

PMID:16099135 PMID:16780908 PMID:17636246 PMID:21697260 PMID:25673294

NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083

G

CD86 molecule

increases expression
multiple interactions
affects expression

nickel sulfate results in increased expression of CD86 mRNA; nickel sulfate results in increased expression of CD86 protein
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]
nickel sulfate affects the expression of CD86 mRNA

PMID:16099135 PMID:16780908 PMID:17374397 PMID:17636246 PMID:18202158 More...

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

CD8 subunit alpha

increases expression

nickel sulfate results in increased expression of CD8A mRNA

NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040

G

CD99 molecule (Xg blood group)

increases expression

nickel sulfate results in increased expression of CD99 mRNA

NCBI chr20:54,418,239...54,422,882

G

cell division cycle 25B

decreases expression

nickel sulfate results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 34, ubiqiutin conjugating enzyme

increases expression

nickel sulfate results in increased expression of CDC34 mRNA

NCBI chr 7:10,017,588...10,023,586
Ensembl chr 7:10,017,588...10,023,186

G

cadherin 1

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CDH1 mRNA; nickel sulfate results in decreased expression of CDH1 protein
pyrazolanthrone promotes the reaction [nickel sulfate results in decreased expression of CDH1 protein]

PMID:15588916 PMID:16780908 PMID:22648416

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 13

decreases expression

nickel sulfate results in decreased expression of CDH13 mRNA

NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459

G

cadherin 16

decreases expression

nickel sulfate results in decreased expression of CDH16 mRNA

NCBI chr19:360,824...371,008
Ensembl chr19:360,824...371,007

G

cadherin 3

decreases expression

nickel sulfate results in decreased expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

G

cadherin 8

decreases expression

nickel sulfate results in decreased expression of CDH8 mRNA

NCBI chr19:5,494,038...5,901,810
Ensembl chr19:5,494,174...5,895,669

G

cyclin-dependent kinase 10

increases expression

nickel sulfate results in increased expression of CDK10 mRNA

NCBI chr19:51,260,012...51,273,009
Ensembl chr19:51,261,356...51,269,078

G

cyclin-dependent kinase 14

decreases expression

nickel sulfate results in decreased expression of CDK14 mRNA

NCBI chr 4:28,666,416...29,258,865
Ensembl chr 4:28,666,843...29,258,861

G

cyclin-dependent kinase 6

decreases expression

nickel sulfate results in decreased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin dependent kinase like 2

increases expression

nickel sulfate results in increased expression of CDKL2 mRNA

NCBI chr14:16,027,381...16,063,257
Ensembl chr14:16,028,363...16,063,252

G

cyclin-dependent kinase-like 5

decreases expression

nickel sulfate results in decreased expression of CDKL5 mRNA

NCBI chr X:33,757,605...33,988,075
Ensembl chr X:33,821,257...33,986,582

G

cyclin-dependent kinase inhibitor 1A

increases expression

nickel sulfate results in increased expression of CDKN1A mRNA

PMID:16100012 PMID:16166746 PMID:16314067

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin dependent kinase inhibitor 2D

increases expression

nickel sulfate results in increased expression of CDKN2D mRNA

NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674

G

cysteine dioxygenase type 1

decreases expression

nickel sulfate results in decreased expression of CDO1 mRNA

NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296

G

CDP-diacylglycerol synthase 2

decreases expression

nickel sulfate results in decreased expression of CDS2 mRNA

NCBI chr 3:119,514,963...119,553,555
Ensembl chr 3:119,515,000...119,553,541

G

chromatin licensing and DNA replication factor 1

increases expression

nickel sulfate results in increased expression of CDT1 mRNA

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

G

choline/ethanolamine phosphotransferase 1

decreases expression

nickel sulfate results in decreased expression of CEPT1 mRNA

NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578

G

ceramide kinase-like

decreases expression

nickel sulfate results in decreased expression of CERKL mRNA

NCBI chr 3:64,238,714...64,344,695
Ensembl chr 3:64,237,522...64,340,675

G

ceramide synthase 6

increases expression

nickel sulfate results in increased expression of LASS6 mRNA

NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848

G

cilia and flagella associated protein 119

increases expression

nickel sulfate results in increased expression of CFAP119 mRNA

NCBI chr 1:182,197,171...182,216,936
Ensembl chr 1:182,192,947...182,202,338

G

cilia and flagella associated protein 251

decreases expression

nickel sulfate results in decreased expression of CFAP251 mRNA

NCBI chr12:33,261,622...33,337,028
Ensembl chr12:33,261,476...33,293,932

G

cilia and flagella associated protein 44

decreases expression

nickel sulfate results in decreased expression of CFAP44 mRNA

NCBI chr11:56,199,772...56,283,964
Ensembl chr11:56,201,049...56,283,986

G

cilia and flagella associated protein 69

increases expression

nickel sulfate results in increased expression of CFAP69 mRNA

NCBI chr 4:28,379,604...28,452,562
Ensembl chr 4:28,375,996...28,450,698

G

CASP8 and FADD-like apoptosis regulator

increases expression

nickel sulfate results in increased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

glycoprotein hormones, alpha polypeptide

increases expression
multiple interactions

nickel sulfate results in increased expression of CGA mRNA
[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 protein; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 protein; [CGA protein co-treated with nickel sulfate] results in decreased expression of HSD17B3 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of STAR mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of STAR protein

PMID:18651567 PMID:29567110

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

chromodomain helicase DNA binding protein 1-like

decreases expression

nickel sulfate results in decreased expression of CHD1L mRNA

NCBI chr 2:185,138,526...185,217,498
Ensembl chr 2:185,139,308...185,217,595

G

choline kinase alpha

increases expression

nickel sulfate results in increased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

charged multivesicular body protein 1A

increases expression

nickel sulfate results in increased expression of CHMP1A mRNA

NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436

G

chordin-like 1

decreases expression

nickel sulfate results in decreased expression of CHRDL1 mRNA

NCBI chr X:106,889,125...106,992,937
Ensembl chr X:106,889,125...106,992,921

G

carbohydrate sulfotransferase 11

decreases expression

nickel sulfate results in decreased expression of CHST11 mRNA

NCBI chr 7:20,524,535...20,743,008
Ensembl chr 7:20,528,100...20,743,111

G

carbohydrate sulfotransferase 15

decreases expression

nickel sulfate results in decreased expression of CHST15 mRNA

NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707

G

cell death-inducing DFFA-like effector a

multiple interactions
decreases expression

[nickel sulfate co-treated with Particulate Matter] results in decreased expression of CIDEA mRNA
nickel sulfate results in decreased expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cell death-inducing DFFA-like effector c

increases expression

nickel sulfate results in increased expression of CIDEC mRNA

PMID:16780908 PMID:17374397

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

CDGSH iron sulfur domain 1

decreases expression

nickel sulfate results in decreased expression of CISD1 mRNA

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

decreases expression

nickel sulfate results in decreased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

creatine kinase B

decreases expression

nickel sulfate results in decreased expression of CKB mRNA

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

chloride voltage-gated channel 4

increases expression

nickel sulfate results in increased expression of CLCN4 mRNA

NCBI chr X:23,729,194...23,795,391
Ensembl chr X:23,729,338...23,793,238

G

claudin 11

increases expression

nickel sulfate results in increased expression of CLDN11 mRNA

NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050

G

chloride intracellular channel 4

increases expression

nickel sulfate results in increased expression of CLIC4 mRNA

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

CAP-GLY domain containing linker protein 2

increases expression

nickel sulfate results in increased expression of CLIP2 mRNA

NCBI chr12:22,163,044...22,227,023
Ensembl chr12:22,163,218...22,227,023

G

clathrin, light chain B

decreases expression
increases expression

nickel sulfate results in decreased expression of CLTB mRNA
nickel sulfate results in increased expression of CLTB mRNA

PMID:16780908 PMID:18651567

NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169

G

carboxymethylenebutenolidase homolog

increases expression

nickel sulfate results in increased expression of CMBL mRNA

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009

G

c-Maf-inducing protein

increases expression

nickel sulfate results in increased expression of CMIP mRNA

NCBI chr19:45,304,597...45,510,653
Ensembl chr19:45,304,031...45,508,709

G

cytidine/uridine monophosphate kinase 2

decreases expression

nickel sulfate results in decreased expression of CMPK2 mRNA

NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183

G

calponin 1

decreases expression

nickel sulfate results in decreased expression of CNN1 mRNA

NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098

G

cyclin and CBS domain divalent metal cation transport mediator 1

decreases expression

nickel sulfate results in decreased expression of CNNM1 mRNA

NCBI chr 1:242,296,367...242,354,957
Ensembl chr 1:242,296,422...242,353,513

G

contactin associated protein 1

decreases expression

nickel sulfate results in decreased expression of CNTNAP1 mRNA

NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611

G

contactin associated protein family member 3

increases expression

nickel sulfate results in increased expression of CNTNAP3 mRNA

NCBI chr17:267,379...455,478
Ensembl chr17:267,508...454,102

G

cochlin

decreases expression

nickel sulfate results in decreased expression of COCH mRNA

NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109

G

collagen type XII alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

G

collagen type XV alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL15A1 mRNA

NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591

G

collagen type XVI alpha 1 chain

increases expression

nickel sulfate results in increased expression of COL16A1 mRNA

NCBI chr 5:142,388,376...142,442,825
Ensembl chr 5:142,388,426...142,442,825

G

collagen type I alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type IV alpha 4 chain

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of COL4A4 mRNA

NCBI chr 9:83,833,173...83,875,436
Ensembl chr 9:83,755,515...83,875,876

G

collagen type IV alpha 5 chain

decreases expression

nickel sulfate results in decreased expression of COL4A5 mRNA

NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692

G

collagen type V alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

collagen type V alpha 2 chain

increases expression

nickel sulfate results in increased expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

collagen type VI alpha 3 chain

decreases expression

nickel sulfate results in decreased expression of COL6A3 mRNA

NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471

G

collagen type VIII alpha 1 chain

decreases expression

nickel sulfate results in decreased expression of COL8A1 mRNA

NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424

G

COMM domain containing 3

decreases expression

nickel sulfate results in decreased expression of COMMD3 mRNA

NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177

G

catechol-O-methyltransferase

increases expression

nickel sulfate results in increased expression of COMT mRNA

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

coronin 2B

decreases expression

nickel sulfate results in decreased expression of CORO2B mRNA

NCBI chr 8:62,906,861...63,017,295
Ensembl chr 8:62,906,867...63,017,302

G

carboxypeptidase E

decreases expression

nickel sulfate results in decreased expression of CPE mRNA

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

G

cytoplasmic polyadenylation element binding protein 3

decreases expression

nickel sulfate results in decreased expression of CPEB3 mRNA

NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560

G

copine 3

decreases expression

nickel sulfate results in decreased expression of CPNE3 mRNA

NCBI chr 5:33,014,658...33,063,934
Ensembl chr 5:33,016,307...33,063,934

G

calcineurin-like phosphoesterase domain containing 1

increases expression

nickel sulfate results in increased expression of CPPED1 mRNA

NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054

G

carboxypeptidase Q

increases expression

nickel sulfate results in increased expression of PGCP mRNA

NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546

G

carnitine palmitoyltransferase 1c

decreases expression

nickel sulfate results in decreased expression of CPT1C mRNA

NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342

G

carboxypeptidase, vitellogenic-like

increases expression

nickel sulfate results in increased expression of CPVL mRNA

NCBI chr 4:82,981,421...83,091,730
Ensembl chr 4:82,981,422...83,085,655

G

cellular retinoic acid binding protein 2

decreases expression

nickel sulfate results in decreased expression of CRABP2 mRNA

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

G

cAMP responsive element binding protein 1

affects expression
multiple interactions
increases phosphorylation

nickel sulfate affects the expression of CREB1 mRNA
[nickel sulfate co-treated with Dinoprostone] results in increased expression of CREB1 protein; CREB1 protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]
nickel sulfate results in increased phosphorylation of CREB1 protein
puerarin inhibits the reaction [nickel sulfate results in increased phosphorylation of CREB1 protein]

PMID:20385217 PMID:23526216 PMID:26607348

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element binding protein 5

decreases expression

nickel sulfate results in decreased expression of CREB5 mRNA

NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325

G

cAMP responsive element modulator

increases expression

nickel sulfate results in increased expression of CREM mRNA

PMID:16780908 PMID:17374397

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

cysteine rich transmembrane BMP regulator 1

increases expression

nickel sulfate results in increased expression of CRIM1 mRNA

NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259

G

cardiolipin synthase 1

decreases expression

nickel sulfate results in decreased expression of CRLS1 mRNA

NCBI chr 3:120,119,822...120,138,674
Ensembl chr 3:120,119,852...120,138,655

G

crooked neck pre-mRNA splicing factor 1

decreases expression

nickel sulfate results in decreased expression of CRNKL1 mRNA

NCBI chr 3:133,338,593...133,354,329
Ensembl chr 3:133,337,039...133,354,302
Ensembl chr 6:133,337,039...133,354,302

G

crystallin beta-gamma domain containing 3

decreases expression

nickel sulfate results in decreased expression of CRYBG3 mRNA

NCBI chr11:40,749,198...40,861,753
Ensembl chr11:40,749,214...40,861,752

G

colony stimulating factor 2 receptor subunit beta

affects expression

nickel sulfate affects the expression of CSF2RB mRNA

NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157

G

colony stimulating factor 3 receptor

increases expression

nickel sulfate results in increased expression of CSF3R mRNA

NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881

G

casein kinase 2 alpha 1

decreases expression

nickel sulfate results in decreased expression of CSNK2A1 mRNA

NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696

G

chondroitin sulfate proteoglycan 4

decreases expression

nickel sulfate results in decreased expression of CSPG4 mRNA

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010

G

cystatin A

decreases expression

nickel sulfate results in decreased expression of CSTA mRNA

NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488

G

cystathionine gamma-lyase

decreases expression

nickel sulfate results in decreased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

catenin alpha-like 1

decreases expression

nickel sulfate results in decreased expression of CTNNAL1 mRNA

NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431

G

CTP synthase 1

increases expression

nickel sulfate results in increased expression of CTPS1 mRNA

NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180

G

cathepsin B

increases expression

nickel sulfate results in increased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin C

decreases expression

nickel sulfate results in decreased expression of CTSC mRNA

PMID:16780908 PMID:17374397 PMID:22714537 PMID:25673294

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

cathepsin F

decreases expression

nickel sulfate results in decreased expression of CTSF mRNA

NCBI chr 1:202,152,777...202,158,525
Ensembl chr 1:202,152,728...202,158,525

G

cathepsin L

increases expression
decreases expression

nickel sulfate results in increased expression of CTSL mRNA
nickel sulfate results in decreased expression of CTSL mRNA

PMID:16780908 PMID:17374397

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cullin 4B

decreases expression

nickel sulfate results in decreased expression of CUL4B mRNA

NCBI chr X:117,287,481...117,326,688
Ensembl chr X:117,287,484...117,326,688

G

CXADR, Ig-like cell adhesion molecule

decreases expression

nickel sulfate results in decreased expression of CXADR mRNA

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

G

C-X-C motif chemokine ligand 1

multiple interactions
increases expression

HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL1 protein]; macrophage stimulatory lipopeptide 2 promotes the reaction [nickel sulfate results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL1 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL1 protein]

PMID:16780908 PMID:18832182

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

increases expression
multiple interactions
decreases expression

nickel sulfate results in increased expression of CXCL10 mRNA
[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of CXCL10 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [nickel sulfate inhibits the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL10 protein]]; nickel sulfate inhibits the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL10 mRNA]; nickel sulfate inhibits the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL10 protein]
nickel sulfate results in decreased expression of CXCL10 mRNA

PMID:12060402 PMID:18096868 PMID:18832182 PMID:23445166

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 16

increases expression

nickel sulfate results in increased expression of CXCL16 mRNA

NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592

G

C-X-C motif chemokine ligand 2

affects expression
increases expression

nickel sulfate affects the expression of CXCL2 mRNA
nickel sulfate results in increased expression of CXCL2 mRNA

PMID:11708899 PMID:18202158

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions
increases expression

HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL1 protein]; macrophage stimulatory lipopeptide 2 promotes the reaction [nickel sulfate results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL1 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL1 protein]

PMID:16166746 PMID:16780908 PMID:18832182

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 6

multiple interactions

nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL6 mRNA]

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

C-X-C motif chemokine receptor 4

decreases expression
affects expression
increases expression

nickel sulfate results in decreased expression of CXCR4 protein
nickel sulfate affects the expression of CXCR4 mRNA
nickel sulfate results in increased expression of CXCR4 mRNA

PMID:15924226 PMID:16780908 PMID:17374397 PMID:17382205 PMID:18202158

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

similar to human chromosome X open reading frame 38

decreases expression

nickel sulfate results in decreased expression of CXORF38 mRNA

NCBI chr X:10,128,070...10,150,904
Ensembl chr X:10,129,657...10,150,900

G

cytochrome b-245 alpha chain

increases expression

nickel sulfate results in increased expression of CYBA mRNA

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome c, somatic

increases expression
multiple interactions

nickel sulfate results in increased expression of CYCS mRNA; nickel sulfate results in increased expression of CYCS protein
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CYCS mRNA]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of CYCS mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]]; Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]

PMID:28296042 PMID:34612572

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytoglobin

decreases expression

nickel sulfate results in decreased expression of CYGB mRNA

NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CYP11A1 mRNA; nickel sulfate results in decreased expression of CYP11A1 protein
[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 protein; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions
decreases expression

[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 protein; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]
nickel sulfate results in decreased expression of CYP17A1 mRNA; nickel sulfate results in decreased expression of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases expression

nickel sulfate results in increased expression of CYP1A1 mRNA
nickel sulfate results in decreased expression of CYP1A1 mRNA

PMID:20491607 PMID:20713136

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression
multiple interactions

nickel sulfate results in decreased expression of CYP1B1 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of CYP1B1 mRNA

PMID:22714537 PMID:31734292

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression
increases expression
multiple interactions

nickel sulfate results in decreased expression of CYP27A1 mRNA
nickel sulfate results in increased expression of CYP27A1 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of CYP27A1 mRNA

PMID:20713136 PMID:22714537 PMID:31734292

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases expression

nickel sulfate results in decreased expression of CYP2B10 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily f, polypeptide 4

affects expression
decreases expression

nickel sulfate affects the expression of CYP2F2 mRNA
nickel sulfate results in decreased expression of CYP2F2 mRNA

PMID:12718980 PMID:16100012

NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896

G

cytochrome P450, family 2, subfamily u, polypeptide 1

decreases expression

nickel sulfate results in decreased expression of CYP2U1 mRNA

NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882

G

cytohesin 1 interacting protein

increases expression

nickel sulfate results in increased expression of CYTIP mRNA

NCBI chr 3:42,698,058...42,774,955
Ensembl chr 3:42,698,768...42,725,993

G

DAB adaptor protein 1

increases expression

nickel sulfate results in increased expression of DAB1 mRNA

NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552

G

dishevelled-binding antagonist of beta-catenin 1

decreases expression

nickel sulfate results in decreased expression of DACT1 mRNA

NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906

G

death associated protein kinase 1

decreases expression

nickel sulfate results in decreased expression of DAPK1 mRNA

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

discoidin, CUB and LCCL domain containing 2

decreases expression

nickel sulfate results in decreased expression of DCBLD2 mRNA

NCBI chr11:42,125,525...42,179,927
Ensembl chr11:42,125,787...42,179,697

G

doublecortin-like kinase 2

increases expression

nickel sulfate results in increased expression of DCLK2 mRNA

NCBI chr 2:172,202,733...172,338,411
Ensembl chr 2:172,208,706...172,338,250

G

dopachrome tautomerase

increases expression

nickel sulfate results in increased expression of DCT mRNA

NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836

G

dCTP pyrophosphatase 1

decreases expression

nickel sulfate results in decreased expression of DCTPP1 mRNA

NCBI chr 1:181,877,440...181,880,833
Ensembl chr 1:181,877,437...181,880,839

G

DDAH family member 2, ADMA-independent

increases expression

nickel sulfate results in increased expression of DDAH2 mRNA

NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of DDIT3 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of DDIT3 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of DDIT3 protein]
nickel sulfate results in increased expression of DDIT3 mRNA; nickel sulfate results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression

nickel sulfate results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

D-aspartate oxidase

increases expression

nickel sulfate results in increased expression of DDO mRNA

NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095

G

discoidin domain receptor tyrosine kinase 1

increases expression

nickel sulfate results in increased expression of DDR1 mRNA

NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468

G

discoidin domain receptor tyrosine kinase 2

increases expression

nickel sulfate results in increased expression of DDR2 mRNA

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

DDRGK domain containing 1

decreases expression

nickel sulfate results in decreased expression of DDRGK1 mRNA

NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680

G

DEAD-box helicase 17

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of DDX17 mRNA

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

G

DExD-box helicase 39B

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of DDX39B mRNA

NCBI chr20:3,547,702...3,585,064
Ensembl chr20:3,572,056...3,584,996

G

DEAF1 transcription factor

increases expression

nickel sulfate results in increased expression of DEAF1 mRNA

NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541

G

differentially expressed in FDCP 8 homolog

increases expression

nickel sulfate results in increased expression of DEF8 mRNA

NCBI chr19:51,474,783...51,495,638
Ensembl chr19:51,474,878...51,495,638

G

DENN domain containing 1B

increases expression

nickel sulfate results in increased expression of DENND1B mRNA

NCBI chr13:50,545,324...50,772,922
Ensembl chr13:50,545,836...50,770,601

G

DENN domain containing 2D

decreases expression

nickel sulfate results in decreased expression of DENND2D mRNA

NCBI chr 2:193,973,231...193,992,275
Ensembl chr 2:193,973,231...193,992,270

G

DEPP autophagy regulator 1

increases expression

nickel sulfate results in increased expression of DEPP1 mRNA

PMID:16780908 PMID:17382205

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

diacylglycerol kinase, alpha

decreases expression

nickel sulfate results in decreased expression of DGKA mRNA

NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110

G

diacylglycerol kinase, eta

decreases expression

nickel sulfate results in decreased expression of DGKH mRNA

NCBI chr15:53,981,079...54,150,470
Ensembl chr15:53,991,481...54,150,706

G

diacylglycerol kinase, iota

decreases expression

nickel sulfate results in decreased expression of DGKI mRNA

NCBI chr 4:65,410,878...65,872,733
Ensembl chr 4:65,420,108...65,872,733

G

dehydrogenase/reductase 11

increases expression

nickel sulfate results in increased expression of DHRS11 mRNA

NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295

G

diaphanous-related formin 2

decreases expression

nickel sulfate results in decreased expression of DIAPH2 mRNA

NCBI chr X:92,395,189...93,234,521
Ensembl chr X:92,395,251...93,229,869

G

iodothyronine deiodinase 2

increases expression

nickel sulfate results in increased expression of DIO2 mRNA

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

dyskerin pseudouridine synthase 1

decreases expression

nickel sulfate results in decreased expression of DKC1 mRNA

PMID:16780908 PMID:17374397

G

distal-less homeobox 1

increases expression

nickel sulfate results in increased expression of DLX1 mRNA

NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780

G

distal-less homeobox 2

increases expression

nickel sulfate results in increased expression of DLX2 mRNA

NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597

G

dynein axonemal assembly factor 9

decreases expression

nickel sulfate results in decreased expression of DNAAF9 mRNA

NCBI chr 3:117,918,047...118,052,641
Ensembl chr 3:117,921,620...118,052,630

G

dynein, axonemal, heavy chain 11

increases expression

nickel sulfate results in increased expression of DNAH11 mRNA

NCBI chr 6:138,839,175...139,155,554
Ensembl chr 6:138,839,177...139,155,536

G

dynein, axonemal, heavy chain 9

decreases expression

nickel sulfate results in decreased expression of DNAH9 mRNA

NCBI chr10:50,496,174...50,864,909
Ensembl chr10:50,497,688...50,864,949

G

DnaJ heat shock protein family (Hsp40) member A4

decreases expression

nickel sulfate results in decreased expression of DNAJA4 mRNA

NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207

G

DnaJ heat shock protein family (Hsp40) member B6

increases expression

nickel sulfate results in increased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member C1

decreases expression

nickel sulfate results in decreased expression of DNAJC1 mRNA

NCBI chr17:80,955,209...81,112,025
Ensembl chr17:80,955,237...81,111,988

G

dynein, axonemal, light intermediate chain 1

decreases expression

nickel sulfate results in decreased expression of DNALI1 mRNA

NCBI chr 5:137,318,475...137,327,313
Ensembl chr 5:137,318,477...137,327,336

G

dynamin 3

decreases expression

nickel sulfate results in decreased expression of DNM3 mRNA

NCBI chr13:74,359,043...74,838,135
Ensembl chr13:74,359,213...74,838,108

G

dedicator of cytokinesis 10

increases expression

nickel sulfate results in increased expression of DOCK10 mRNA

NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525

G

dedicator of cytokinesis 11

increases expression

nickel sulfate results in increased expression of DOCK11 mRNA

NCBI chr X:115,131,720...115,314,854
Ensembl chr X:115,131,909...115,314,854

G

dipeptidylpeptidase 4

decreases expression
increases expression

nickel sulfate results in decreased expression of DPP4 mRNA
nickel sulfate results in increased expression of DPP4 mRNA

PMID:16780908 PMID:22714537

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

dipeptidylpeptidase 7

decreases expression

nickel sulfate results in decreased expression of DPP7 mRNA

NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355

G

dpy-19 like C-mannosyltransferase 3

decreases expression

nickel sulfate results in decreased expression of DPY19L3 mRNA

NCBI chr 1:88,350,303...88,417,339
Ensembl chr 1:88,350,303...88,417,339

G

dihydropyrimidine dehydrogenase

decreases expression

nickel sulfate results in decreased expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

DNA-damage regulated autophagy modulator 1

increases expression

nickel sulfate results in increased expression of DRAM1 mRNA

NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765

G

dermatan sulfate epimerase

decreases expression

nickel sulfate results in decreased expression of DSE mRNA

NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992

G

dermatan sulfate epimerase-like

increases expression

nickel sulfate results in increased expression of DSEL mRNA

NCBI chr13:186,413...192,592
Ensembl chr13:175,805...192,647

G

desmoglein 2

increases expression

nickel sulfate results in increased expression of DSG2 mRNA

PMID:16780908 PMID:22714537

NCBI chr18:11,846,207...11,904,630
Ensembl chr18:11,846,183...11,904,156

G

destrin, actin depolymerizing factor

decreases expression

nickel sulfate results in decreased expression of DSTN mRNA

NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379

G

D-aminoacyl-tRNA deacylase 1

decreases expression

nickel sulfate results in decreased expression of DTD1 mRNA

NCBI chr 3:131,995,870...132,158,646
Ensembl chr 3:131,995,861...132,158,659

G

deltex E3 ubiquitin ligase 3

decreases expression

nickel sulfate results in decreased expression of DTX3 mRNA

NCBI chr 7:63,013,769...63,018,431
Ensembl chr 7:63,013,371...63,018,522

G

dual specificity phosphatase 1

increases expression

nickel sulfate results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 10

increases expression

nickel sulfate results in increased expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

dual specificity phosphatase 22

increases expression

nickel sulfate results in increased expression of DUSP22 mRNA

NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321

G

dual specificity phosphatase 23

decreases expression

nickel sulfate results in decreased expression of DUSP23 mRNA

NCBI chr13:85,097,899...85,100,054
Ensembl chr13:85,097,899...85,100,093

G

dual specificity phosphatase 4

increases expression

nickel sulfate results in increased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity phosphatase 5

increases expression

nickel sulfate results in increased expression of DUSP5 mRNA

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

dynein cytoplasmic 2 heavy chain 1

decreases expression

nickel sulfate results in decreased expression of DYNC2H1 mRNA

NCBI chr 8:4,189,067...4,412,183
Ensembl chr 8:4,189,257...4,412,183

G

dysferlin

decreases expression

nickel sulfate results in decreased expression of DYSF mRNA

NCBI chr 4:116,490,877...116,690,709
Ensembl chr 4:116,490,616...116,690,709

G

Epstein-Barr virus induced 3

increases expression
multiple interactions

nickel sulfate results in increased expression of EBI3 mRNA
BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of EBI3 mRNA]; TLR4 protein affects the reaction [nickel sulfate results in increased expression of EBI3 mRNA]

PMID:16780908 PMID:30421605

NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544

G

endothelin converting enzyme 1

increases expression

nickel sulfate results in increased expression of ECE1 mRNA

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

G

enoyl CoA hydratase domain containing 3

decreases expression

nickel sulfate results in decreased expression of ECHDC3 mRNA

NCBI chr17:72,070,697...72,093,519
Ensembl chr17:72,070,668...72,093,516

G

extracellular matrix protein 1

increases expression

nickel sulfate results in increased expression of ECM1 mRNA

NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671

G

EDAR associated via death domain

increases expression

nickel sulfate results in increased expression of EDARADD mRNA

NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447

G

ER degradation enhancing alpha-mannosidase like protein 3

decreases expression

nickel sulfate results in decreased expression of EDEM3 mRNA

NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523

G

EGF like repeats and discoidin domains 3

decreases expression

nickel sulfate results in decreased expression of EDIL3 mRNA

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008

G

endothelin 1

increases expression

nickel sulfate results in increased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

EGF containing fibulin extracellular matrix protein 2

decreases expression

nickel sulfate results in decreased expression of EFEMP2 mRNA

NCBI chr 1:202,781,692...202,789,784
Ensembl chr 1:202,781,665...202,789,414

G

EF-hand domain containing 1

increases expression

nickel sulfate results in increased expression of EFHC1 mRNA

NCBI chr 9:23,375,815...23,414,283
Ensembl chr 9:23,375,840...23,414,283

G

ephrin A1

multiple interactions
increases expression

[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of EFNA1 mRNA
nickel sulfate results in increased expression of EFNA1 mRNA

PMID:18651567 PMID:18832182

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

G

ephrin A3

increases expression
multiple interactions

nickel sulfate results in increased expression of EFNA3 mRNA
[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of EFNA3 mRNA

NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736

G

ephrin A5

decreases expression

nickel sulfate results in decreased expression of EFNA5 mRNA

NCBI chr 9:102,316,753...102,595,480
Ensembl chr 9:102,320,295...102,597,413

G

epidermal growth factor receptor

multiple interactions

[TGFA protein binds to and affects the activity of EGFR protein] which results in decreased susceptibility to nickel sulfate

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression

nickel sulfate results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

increases expression

nickel sulfate results in increased expression of EHHADH mRNA

PMID:17374397 PMID:22714537

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

euchromatic histone lysine methyltransferase 2

increases expression

nickel sulfate results in increased expression of EHMT2 mRNA

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

EI24, autophagy associated transmembrane protein

decreases expression

nickel sulfate results in decreased expression of EI24 mRNA

NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571

G

eukaryotic translation initiation factor 1A, X-linked

decreases expression

nickel sulfate results in decreased expression of EIF1A mRNA

NCBI chr X:35,498,698...35,513,402
Ensembl chr X:35,498,517...35,513,335

G

eukaryotic translation initiation factor 4 gamma 1

increases expression

nickel sulfate results in increased expression of EIF4G1 mRNA

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

G

elastin

increases expression

nickel sulfate results in increased expression of ELN mRNA

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

ELOVL fatty acid elongase 2

increases expression

nickel sulfate results in increased expression of ELOVL2 mRNA

NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848

G

ELOVL fatty acid elongase 3

multiple interactions

[nickel sulfate co-treated with Particulate Matter] results in decreased expression of ELOVL3 mRNA

NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115

G

ELOVL fatty acid elongase 7

increases expression

nickel sulfate results in increased expression of ELOVL7 mRNA

NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845

G

embigin

decreases expression

nickel sulfate results in decreased expression of EMB mRNA

NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050

G

ER membrane protein complex subunit 8

increases expression

nickel sulfate results in increased expression of EMC8 mRNA

NCBI chr19:48,708,304...48,721,626
Ensembl chr19:48,582,574...48,721,543

G

EMAP like 1

increases expression

nickel sulfate results in increased expression of EML1 mRNA

NCBI chr 6:127,283,968...127,457,246
Ensembl chr 6:127,284,029...127,457,246

G

epithelial membrane protein 1

decreases expression

nickel sulfate results in decreased expression of EMP1 mRNA

NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904

G

ectodermal-neural cortex 1

decreases expression

nickel sulfate results in decreased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

endonuclease domain containing 1

decreases expression

nickel sulfate results in decreased expression of ENDOD1 mRNA

NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:11,211,110...11,238,892

G

enolase 1

increases expression

nickel sulfate results in increased expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

enolase 2

increases expression

nickel sulfate results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

enolase 3

affects expression

nickel sulfate affects the expression of ENO3 mRNA

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

increases expression

nickel sulfate results in increased expression of ENPP1 mRNA

NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715

G

ectonucleotide pyrophosphatase/phosphodiesterase 4

decreases expression

nickel sulfate results in decreased expression of ENPP4 mRNA

NCBI chr 9:16,888,923...16,898,860
Ensembl chr 9:16,887,739...16,898,860

G

ectonucleoside triphosphate diphosphohydrolase 1

increases expression

nickel sulfate results in increased expression of ENTPD1 mRNA

NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317

G

ectonucleoside triphosphate diphosphohydrolase 6

decreases expression

nickel sulfate results in decreased expression of ENTPD6 mRNA

NCBI chr 3:139,575,659...139,598,163
Ensembl chr 3:139,575,686...139,598,154

G

endothelial PAS domain protein 1

multiple interactions
increases stability
increases expression

[HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in decreased expression of USP28 protein]; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in increased degradation of MYC protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of EPAS1 protein]
nickel sulfate results in increased stability of EPAS1 protein
nickel sulfate results in increased expression of EPAS1 mRNA; nickel sulfate results in increased expression of EPAS1 protein

PMID:16288478 PMID:20046830 PMID:22714537

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

epithelial cell adhesion molecule

decreases expression

nickel sulfate results in decreased expression of EPCAM mRNA

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

ependymin related 1

increases expression

nickel sulfate results in increased expression of EPDR1 mRNA

NCBI chr17:45,333,932...45,358,597
Ensembl chr17:45,333,956...45,358,594

G

Eph receptor A4

increases expression

nickel sulfate results in increased expression of EPHA4 mRNA

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

G

Eph receptor B6

increases expression

nickel sulfate results in increased expression of EPHB6 mRNA

NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230

G

EPM2A interacting protein 1

decreases expression

nickel sulfate results in decreased expression of EPM2AIP1 mRNA

NCBI chr 8:111,233,871...111,241,219
Ensembl chr 8:111,233,826...111,241,871

G

erb-b2 receptor tyrosine kinase 3

decreases expression

nickel sulfate results in decreased expression of ERBB3 mRNA

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

esterase D

increases expression

nickel sulfate results in increased expression of ESD mRNA

NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144

G

ESF1 nucleolar pre-rRNA processing protein homolog

decreases expression

nickel sulfate results in decreased expression of ESF1 mRNA

NCBI chr 3:127,454,744...127,507,941
Ensembl chr 3:127,454,811...127,507,817

G

enhancer trap locus 4

decreases expression

nickel sulfate results in decreased expression of KIAA1217 mRNA

NCBI chr17:82,841,075...83,304,868
Ensembl chr17:82,495,041...83,304,715

G

ETS proto-oncogene 1, transcription factor

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in increased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

ETS proto-oncogene 2, transcription factor

increases expression

nickel sulfate results in increased expression of ETS2 mRNA

PMID:16780908 PMID:18651567

NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319

G

ETS variant transcription factor 2

increases expression

nickel sulfate results in increased expression of ETV2 mRNA

NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431

G

ETS variant transcription factor 6

increases expression

nickel sulfate results in increased expression of ETV6 mRNA

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

G

eva-1 homolog C

increases expression

nickel sulfate results in increased expression of EVA1C mRNA

NCBI chr11:30,089,510...30,163,596
Ensembl chr11:30,089,365...30,163,596

G

ecotropic viral integration site 2B

increases expression

nickel sulfate results in increased expression of EVI2B mRNA

NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560

G

exocyst complex component 2

increases expression

nickel sulfate results in increased expression of EXOC2 mRNA

NCBI chr17:33,506,289...33,698,246
Ensembl chr17:33,506,338...33,693,289

G

exocyst complex component 6

decreases expression

nickel sulfate results in decreased expression of EXOC6 mRNA

NCBI chr 1:235,314,612...235,457,824
Ensembl chr 1:235,300,369...235,457,015

G

exosome component 8

decreases expression

nickel sulfate results in decreased expression of EXOSC8 mRNA

NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928

G

exophilin 5

decreases expression

nickel sulfate results in decreased expression of EXPH5 mRNA

NCBI chr 8:53,698,825...53,775,371
Ensembl chr 8:53,698,852...53,773,169

G

EYA transcriptional coactivator and phosphatase 1

decreases expression

nickel sulfate results in decreased expression of EYA1 mRNA

NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483

G

EYA transcriptional coactivator and phosphatase 2

decreases expression

nickel sulfate results in decreased expression of EYA2 mRNA

NCBI chr 3:154,335,598...154,519,006
Ensembl chr 3:154,335,400...154,518,793

G

coagulation factor XIII A1 chain

decreases expression

nickel sulfate results in decreased expression of F13A1 mRNA

PMID:16780908 PMID:17374397

NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700

G

coagulation factor II (thrombin) receptor-like 2

decreases expression

nickel sulfate results in decreased expression of F2RL2 mRNA

NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098

G

coagulation factor III, tissue factor

increases expression
decreases expression

nickel sulfate results in increased expression of F3 mRNA
nickel sulfate results in decreased expression of F3 mRNA

PMID:16100012 PMID:22714537

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid binding protein 3

increases expression
decreases expression

nickel sulfate results in increased expression of FABP3 mRNA
nickel sulfate results in decreased expression of FABP3 mRNA

PMID:17382205 PMID:22714537

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

fatty acid binding protein 5

increases expression
decreases expression

nickel sulfate results in increased expression of FABP5 mRNA
nickel sulfate results in decreased expression of FABP5 mRNA

PMID:16780908 PMID:18651567

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

family with sequence similarity 117, member B

increases expression

nickel sulfate results in increased expression of FAM117B mRNA

NCBI chr 9:61,340,284...61,418,531
Ensembl chr 9:61,340,249...61,408,483

G

family with sequence similarity 120 member C

increases expression

nickel sulfate results in increased expression of FAM120C mRNA

NCBI chr X:20,324,046...20,477,831
Ensembl chr X:20,323,381...20,477,275

G

family with sequence similarity 162, member A

increases expression
decreases expression

nickel sulfate results in increased expression of FAM162A mRNA
nickel sulfate results in decreased expression of FAM162A mRNA

PMID:17382205 PMID:22714537

NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239

G

family with sequence similarity 171, member B

increases expression

nickel sulfate results in increased expression of FAM171B mRNA

NCBI chr 3:68,930,755...68,986,113
Ensembl chr 3:68,930,822...68,986,127

G

family with sequence similarity 221, member A

decreases expression

nickel sulfate results in decreased expression of FAM221A mRNA

NCBI chr 4:78,337,296...78,358,918
Ensembl chr 4:78,337,296...78,358,909

G

FAM3 metabolism regulating signaling molecule C

decreases expression

nickel sulfate results in decreased expression of FAM3C mRNA

NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078

G

family with sequence similarity 43, member A

increases expression

nickel sulfate results in increased expression of FAM43A mRNA

NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401

G

family with sequence similarity 81, member A

increases expression

nickel sulfate results in increased expression of FAM81A mRNA

NCBI chr 8:70,762,852...70,821,898
Ensembl chr 8:70,763,614...70,821,875

G

FA complementation group A

increases expression

nickel sulfate results in increased expression of FANCA mRNA

NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527

G

FERM, ARH/RhoGEF and pleckstrin domain protein 1

increases expression

nickel sulfate results in increased expression of FARP1 mRNA

NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299

G

phenylalanyl-tRNA synthetase 2, mitochondrial

increases expression

nickel sulfate results in increased expression of FARS2 mRNA

NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337

G

fatty acid synthase

increases expression
decreases expression

nickel sulfate results in increased expression of FASN mRNA
nickel sulfate results in decreased expression of FASN mRNA

PMID:16100012 PMID:16780908

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

failed axon connections homolog, metaxin like GST domain containing

increases expression

nickel sulfate results in increased expression of FAXC mRNA

NCBI chr 5:35,480,137...35,539,741
Ensembl chr 5:35,480,402...35,544,446

G

fibulin 2

decreases expression

nickel sulfate results in decreased expression of FBLN2 mRNA

NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948

G

fibrillin 1

decreases expression

nickel sulfate results in decreased expression of FBN1 mRNA

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

G

fibrillin 2

decreases expression

nickel sulfate results in decreased expression of FBN2 mRNA

NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976

G

F-box protein 32

increases expression

nickel sulfate results in increased expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

F-box protein 4

decreases expression

nickel sulfate results in decreased expression of FBXO4 mRNA

NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792

G

f-box protein 9

decreases expression

nickel sulfate results in decreased expression of FBXO9 mRNA

NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949

G

F-box and WD repeat domain containing 7

multiple interactions

FBXW7 mRNA affects the reaction [nickel sulfate results in increased degradation of MYC protein]; FBXW7 protein affects the reaction [nickel sulfate results in increased degradation of MYC protein]

NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941

G

Fc gamma receptor 2B

increases expression

nickel sulfate results in increased expression of FCGR2B mRNA

NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778

G

ferrochelatase

increases expression

nickel sulfate results in increased expression of FECH mRNA

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

fetuin B

decreases expression

nickel sulfate results in decreased expression of FETUB mRNA

NCBI chr11:78,082,158...78,093,022
Ensembl chr11:78,082,156...78,095,135

G

fasciculation and elongation protein zeta 2

increases expression

nickel sulfate results in increased expression of FEZ2 mRNA

NCBI chr 6:16,654,572...16,694,628
Ensembl chr 6:16,654,614...16,694,626

G

fibroblast growth factor 1

decreases expression

nickel sulfate results in decreased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 2

increases expression

nickel sulfate results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 5

decreases expression

nickel sulfate results in decreased expression of FGF5 mRNA

NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997

G

fibroblast growth factor receptor 2

increases expression

nickel sulfate results in increased expression of FGFR2 protein

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fibrinogen-like 2

decreases expression

nickel sulfate results in decreased expression of FGL2 mRNA

PMID:16780908 PMID:17374397

NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207

G

filamin A interacting protein 1-like

decreases expression

nickel sulfate results in decreased expression of FILIP1L mRNA

NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415

G

FKBP prolyl isomerase 1A

decreases expression

nickel sulfate results in decreased expression of FKBP1A mRNA

NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743

G

FKBP prolyl isomerase 1B

decreases expression

nickel sulfate results in decreased expression of FKBP1B mRNA

NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653

G

filaggrin

decreases expression

nickel sulfate results in decreased expression of FLG mRNA

NCBI chr 2:178,884,793...178,912,986

G

Fli-1 proto-oncogene, ETS transcription factor

increases expression

nickel sulfate results in increased expression of FLI1 mRNA

NCBI chr 8:30,831,422...30,950,468
Ensembl chr 8:30,832,753...30,950,433

G

filamin A

increases expression

nickel sulfate results in increased expression of FLNA mRNA

NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052

G

filamin C

decreases expression

nickel sulfate results in decreased expression of FLNC mRNA

NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844

G

flotillin 1

increases expression

nickel sulfate results in increased expression of FLOT1 mRNA

NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978

G

Fms related receptor tyrosine kinase 1

increases expression

nickel sulfate results in increased expression of FLT1 mRNA

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

Fms related receptor tyrosine kinase 3 ligand

decreases expression

nickel sulfate results in decreased expression of FLT3L mRNA

NCBI chr 1:95,615,056...95,620,463
Ensembl chr 1:95,609,370...95,620,463

G

fragile X messenger ribonucleoprotein 1

decreases expression

nickel sulfate results in decreased expression of FMR1 mRNA

NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050

G

fibronectin 1

increases expression

nickel sulfate results in increased expression of FN1 mRNA; nickel sulfate results in increased expression of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

fibronectin type III domain containing 3a

increases expression

nickel sulfate results in increased expression of FNDC3A mRNA

NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

nickel sulfate results in increased expression of FOS mRNA

PMID:16780908 PMID:19131640

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 2, AP-1 transcription factor subunit

decreases expression
increases expression

nickel sulfate results in decreased expression of FOSL2 mRNA
nickel sulfate results in increased expression of FOSL2 mRNA

PMID:16780908 PMID:17374397

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box C2

increases expression

nickel sulfate results in increased expression of FOXC2 mRNA

NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737

G

forkhead box F2

increases expression

nickel sulfate results in increased expression of FOXF2 mRNA

NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176

G

formyl peptide receptor 3

increases expression

nickel sulfate results in increased expression of FPR3 mRNA

NCBI chr 1:58,884,427...58,893,472
Ensembl chr 1:58,845,118...58,893,467

G

FERM domain containing 3

increases expression

nickel sulfate results in increased expression of FRMD3 mRNA

NCBI chr 5:87,764,755...88,031,091
Ensembl chr 5:87,764,604...88,031,091

G

FERM domain containing 4A

decreases expression

nickel sulfate results in decreased expression of FRMD4A mRNA

NCBI chr17:73,667,787...74,258,487
Ensembl chr17:73,667,789...74,258,687

G

FERM domain containing 5

decreases expression

nickel sulfate results in decreased expression of FRMD5 mRNA

NCBI chr 3:108,492,099...108,763,715
Ensembl chr 3:108,474,562...108,763,498

G

FRY microtubule binding protein

decreases expression

nickel sulfate results in decreased expression of FRY mRNA

NCBI chr12:4,493,890...4,887,118
Ensembl chr12:4,493,891...4,799,116

G

follistatin

increases expression

nickel sulfate results in increased expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

follistatin like 3

decreases expression

nickel sulfate results in decreased expression of FSTL3 mRNA

NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639

G

ferritin heavy chain 1

increases expression

nickel sulfate results in increased expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

increases expression

nickel sulfate results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

ferritin mitochondrial

increases expression

nickel sulfate results in increased expression of FTMT protein

NCBI chr18:45,758,874...45,760,123
Ensembl chr18:45,758,874...45,760,123

G

alpha-L-fucosidase 1

decreases expression

nickel sulfate results in decreased expression of FUCA1 mRNA

NCBI chr 5:148,152,718...148,169,972
Ensembl chr 5:148,152,700...148,169,972

G

FUN14 domain containing 2

decreases expression

nickel sulfate results in decreased expression of FUNDC2 mRNA

NCBI chr18:128,473...138,232
Ensembl chr18:132,248...138,345

G

Fus RNA binding protein

increases expression

nickel sulfate results in increased expression of FUS mRNA

NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414

G

FYN proto-oncogene, Src family tyrosine kinase

increases expression

nickel sulfate results in increased expression of FYN mRNA

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

frizzled class receptor 2

decreases expression

nickel sulfate results in decreased expression of FZD2 mRNA

PMID:16100012 PMID:16166746

NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334

G

frizzled class receptor 3

decreases expression

nickel sulfate results in decreased expression of FZD3 mRNA

NCBI chr15:39,421,366...39,488,369
Ensembl chr15:39,421,355...39,488,369

G

frizzled class receptor 6

increases expression

nickel sulfate results in increased expression of FZD6 mRNA

NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776

G

G4 protein

increases expression

nickel sulfate results in increased expression of C6ORF47 mRNA

NCBI chr20:3,693,691...3,696,194
Ensembl chr20:3,693,649...3,696,088

G

glucose-6-phosphate dehydrogenase

increases expression
multiple interactions
decreases activity

nickel sulfate results in increased expression of G6PD mRNA
naringin inhibits the reaction [nickel sulfate results in decreased activity of G6PD protein]

PMID:20566472 PMID:20950607

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor associated protein like 1

increases expression

nickel sulfate results in increased expression of GABARAPL1 mRNA

NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450

G

glutamate decarboxylase 1

increases expression

nickel sulfate results in increased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

galanin and GMAP prepropeptide

decreases expression

nickel sulfate results in decreased expression of GAL mRNA

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

galactose-3-O-sulfotransferase 4

increases expression

nickel sulfate results in increased expression of GAL3ST4 mRNA

NCBI chr12:17,267,963...17,276,951
Ensembl chr12:17,267,963...17,276,833

G

galactosylceramidase

decreases expression

nickel sulfate results in decreased expression of GALC mRNA

NCBI chr 6:117,452,888...117,522,281
Ensembl chr 6:117,452,895...117,515,830

G

galactosamine (N-acetyl)-6-sulfatase

increases expression

nickel sulfate results in increased expression of GALNS mRNA

NCBI chr19:50,628,639...50,662,477
Ensembl chr19:50,628,552...50,662,246

G

gigaxonin

increases expression

nickel sulfate results in increased expression of GAN mRNA

NCBI chr19:45,207,783...45,265,066
Ensembl chr19:45,207,184...45,254,107

G

glyceraldehyde-3-phosphate dehydrogenase

affects expression

nickel sulfate affects the expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

growth arrest specific 6

decreases expression

nickel sulfate results in decreased expression of GAS6 mRNA

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

growth arrest specific 8

increases expression

nickel sulfate results in increased expression of GAS8 mRNA

NCBI chr19:51,552,770...51,572,323
Ensembl chr19:51,552,816...51,572,305

G

glycine amidinotransferase

decreases expression

nickel sulfate results in decreased expression of GATM mRNA

NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129

G

guanylate binding protein 1

increases expression

nickel sulfate results in increased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

guanylate binding protein 4

increases expression

nickel sulfate results in increased expression of GBP4 mRNA

NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879

G

glutamate-cysteine ligase, catalytic subunit

increases expression

nickel sulfate results in increased expression of GCLC mRNA

PMID:16100012 PMID:20491607 PMID:20566472

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

nickel sulfate results in increased expression of GCLM mRNA

PMID:16314067 PMID:20566472

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glucosaminyl (N-acetyl) transferase 2

increases expression

nickel sulfate results in increased expression of GCNT2 mRNA

NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611

G

glucosaminyl (N-acetyl) transferase 4

increases expression

nickel sulfate results in increased expression of GCNT4 mRNA

NCBI chr 2:28,253,325...28,283,082
Ensembl chr 2:28,252,860...28,283,082

G

glycine cleavage system protein H

increases expression

nickel sulfate results in increased expression of GCSH mRNA

NCBI chr19:45,036,013...45,046,770
Ensembl chr19:45,036,011...45,046,792

G

growth differentiation factor 15

increases expression

nickel sulfate results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glial cell derived neurotrophic factor

decreases expression

nickel sulfate results in decreased expression of GDNF mRNA

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glutamine-fructose-6-phosphate transaminase 2

increases expression

nickel sulfate results in increased expression of GFPT2 mRNA

NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329

G

GDNF family receptor alpha 2

decreases expression

nickel sulfate results in decreased expression of GFRA2 mRNA

NCBI chr15:45,941,841...46,033,715
Ensembl chr15:45,941,828...46,033,714

G

GDP-L-fucose synthase

increases expression

nickel sulfate results in increased expression of GFUS mRNA

NCBI chr 7:107,612,087...107,617,005
Ensembl chr 7:107,612,094...107,616,948

G

gamma-glutamyltransferase 1

increases activity
multiple interactions

nickel sulfate results in increased activity of GGT1 protein
troxerutin inhibits the reaction [nickel sulfate results in increased activity of GGT1 protein]

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

GINS complex subunit 1

decreases expression

nickel sulfate results in decreased expression of GINS1 mRNA

NCBI chr 3:139,724,513...139,745,930
Ensembl chr 3:139,724,490...139,745,936

G

GINS complex subunit 2

increases expression

nickel sulfate results in increased expression of GINS2 mRNA

NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339

G

gap junction protein, alpha 1

increases expression

nickel sulfate results in increased expression of GJA1 mRNA

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glucocorticoid induced 1

decreases expression

nickel sulfate results in decreased expression of GLCCI1 mRNA

NCBI chr 4:36,307,956...36,635,614
Ensembl chr 4:36,307,903...36,635,612

G

GLI pathogenesis-related 1

decreases expression

nickel sulfate results in decreased expression of GLIPR1 mRNA

NCBI chr 7:47,487,342...47,498,974
Ensembl chr 7:47,487,345...47,498,429

G

GLI pathogenesis-related 2

decreases expression

nickel sulfate results in decreased expression of GLIPR2 mRNA

NCBI chr 5:58,170,417...58,202,258
Ensembl chr 5:58,170,425...58,202,272

G

GLIS family zinc finger 3

decreases expression

nickel sulfate results in decreased expression of GLIS3 mRNA

NCBI chr 1:225,976,029...226,395,849
Ensembl chr 1:225,976,326...226,395,899

G

glucagon-like peptide 2 receptor

increases expression

nickel sulfate results in increased expression of GLP2R mRNA

NCBI chr10:52,402,748...52,466,012
Ensembl chr10:52,402,748...52,466,012

G

glycine receptor, beta

decreases expression

nickel sulfate results in decreased expression of GLRB mRNA

NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489

G

glutamate-ammonia ligase

increases expression

nickel sulfate results in increased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

ganglioside GM2 activator

decreases expression
increases expression

nickel sulfate results in decreased expression of GM2A mRNA
nickel sulfate results in increased expression of GM2A mRNA

NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757

G

guanosine monophosphate reductase

increases expression

nickel sulfate results in increased expression of GMPR mRNA

NCBI chr17:19,151,820...19,189,626
Ensembl chr17:19,151,815...19,189,621

G

G protein subunit alpha 15

increases expression

nickel sulfate results in increased expression of GNA15 mRNA

NCBI chr 7:8,184,632...8,205,508
Ensembl chr 7:8,184,861...8,205,508

G

G protein subunit alpha L

increases expression

nickel sulfate results in increased expression of GNAL mRNA

NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599

G

G protein subunit alpha z

increases expression

nickel sulfate results in increased expression of GNAZ mRNA

NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907

G

G protein subunit beta 2

increases expression

nickel sulfate results in increased expression of GNB2 mRNA

NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019

G

G protein subunit gamma 11

increases expression

nickel sulfate results in increased expression of GNG11 mRNA

NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442

G

glycoprotein IX (platelet)

increases expression

nickel sulfate results in increased expression of GP9 mRNA

NCBI chr 4:120,235,500...120,237,110
Ensembl chr 4:120,235,421...120,237,110

G

glycerol-3-phosphate acyltransferase 3

increases expression

nickel sulfate results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

G patch domain containing 2-like

decreases expression

nickel sulfate results in decreased expression of GPATCH2L mRNA

NCBI chr 6:105,883,383...105,935,644
Ensembl chr 6:105,883,460...105,934,888

G

glypican 4

increases expression

nickel sulfate results in increased expression of GPC4 mRNA

NCBI chr X:131,644,711...131,755,349
Ensembl chr X:131,644,704...131,755,284

G

G protein-coupled estrogen receptor 1

increases expression

nickel sulfate results in increased expression of GPER1 mRNA

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

gephyrin

decreases expression

nickel sulfate results in decreased expression of GPHN mRNA

NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612

G

glycoprotein m6b

increases expression

nickel sulfate results in increased expression of GPM6B mRNA

NCBI chr X:28,057,788...28,204,409
Ensembl chr X:28,059,450...28,204,211

G

glycoprotein nmb

increases expression

nickel sulfate results in increased expression of GPNMB mRNA

PMID:16314067 PMID:22714537

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

G protein-coupled receptor 39

increases expression

nickel sulfate results in increased expression of GPR39 mRNA

NCBI chr13:37,115,258...37,327,312
Ensembl chr13:37,115,102...37,328,267

G

G protein-coupled receptor 4

decreases expression

nickel sulfate results in decreased expression of GPR4 mRNA

NCBI chr 1:78,865,376...78,877,126
Ensembl chr 1:78,865,409...78,876,599

G

G protein-coupled receptor, class C, group 5, member B

increases expression

nickel sulfate results in increased expression of GPRC5B mRNA

NCBI chr 1:173,316,904...173,340,933
Ensembl chr 1:173,316,907...173,340,932

G

glutamic--pyruvic transaminase

increases activity
multiple interactions

nickel sulfate results in increased activity of GPT protein
troxerutin inhibits the reaction [nickel sulfate results in increased activity of GPT protein]
puerarin inhibits the reaction [nickel sulfate results in increased activity of GPT protein]

PMID:24112957 PMID:26607348

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 3

increases expression

nickel sulfate results in increased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione peroxidase 4

increases expression
multiple interactions

nickel sulfate results in increased expression of GPX4 mRNA
[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of GPX4 mRNA

PMID:18651567 PMID:31734292

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutathione peroxidase 7

decreases expression

nickel sulfate results in decreased expression of GPX7 mRNA

NCBI chr 5:123,145,151...123,153,141
Ensembl chr 5:123,144,331...123,153,004

G

GRAM domain containing 1C

increases expression

nickel sulfate results in increased expression of GRAMD1C mRNA

NCBI chr11:56,633,229...56,718,570
Ensembl chr11:56,633,227...56,718,570

G

gremlin 1, DAN family BMP antagonist

decreases expression

nickel sulfate results in decreased expression of GREM1 mRNA

NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082

G

Gse1 coiled-coil protein

increases expression

nickel sulfate results in increased expression of GSE1 mRNA

NCBI chr19:48,274,164...48,629,456
Ensembl chr19:48,274,127...48,629,458

G

glycogen synthase kinase 3 beta

increases expression

nickel sulfate results in increased expression of GSK3B mRNA

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

increases expression

nickel sulfate results in increased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

G1 to S phase transition 2

decreases expression

nickel sulfate results in decreased expression of GSPT2 mRNA

NCBI chr X:59,587,237...59,589,758
Ensembl chr X:59,587,276...59,594,162

G

glutathione-disulfide reductase

increases expression
multiple interactions
decreases activity

nickel sulfate results in increased expression of GSR mRNA
naringin inhibits the reaction [nickel sulfate results in decreased activity of GSR protein]

PMID:20566472 PMID:20950607

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

general transcription factor IIB

increases expression

nickel sulfate results in increased expression of GTF2B mRNA

NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651

G

GTP binding protein 6 (putative)

increases expression

nickel sulfate results in increased expression of GTPBP6 mRNA

NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873

G

guanylate kinase 1

increases expression

nickel sulfate results in increased expression of GUK1 mRNA

NCBI chr10:43,971,514...43,988,658
Ensembl chr10:43,971,509...43,980,107

G

GULP PTB domain containing engulfment adaptor 1

increases expression

nickel sulfate results in increased expression of GULP1 mRNA

NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005

G

GDNF-inducible zinc finger protein 1

decreases expression

nickel sulfate results in decreased expression of GZF1 mRNA

NCBI chr 3:136,119,004...136,131,223
Ensembl chr 3:136,119,113...136,131,223

G

granzyme F

decreases expression

nickel sulfate results in decreased expression of GZMF mRNA

NCBI chr15:30,005,361...30,018,649
Ensembl chr15:30,007,267...30,018,649

G

H1.0 linker histone

decreases expression

nickel sulfate results in decreased expression of H1-0 mRNA

NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694

G

H1.10 linker histone

increases expression

nickel sulfate results in increased expression of H1-10 mRNA

NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448

G

H2A clustered histone 18

increases expression

nickel sulfate results in increased expression of H2AC18 mRNA

NCBI chr 2:183,808,398...183,808,992

G

H3.4 histone, cluster member

increases methylation

nickel sulfate results in increased methylation of H3-4 protein
nickel sulfate results in increased methylation of H3F4 protein

NCBI chr10:43,740,702...43,741,262

G

histone H4C like 1

decreases expression

nickel sulfate results in decreased expression of H4C6 mRNA

NCBI chr17:41,368,743...41,426,735

G

3-hydroxyacyl-CoA dehydratase 4

decreases expression

nickel sulfate results in decreased expression of HACD4 mRNA

NCBI chr 5:102,887,597...102,915,376
Ensembl chr 5:102,887,588...102,915,338

G

hemoglobin alpha, adult chain 1

affects expression

nickel sulfate affects the expression of HBA-A1 mRNA

NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392

G

hemoglobin, beta adult minor chain

decreases expression

nickel sulfate results in decreased expression of HBB-B2 mRNA

NCBI chr 1:158,243,696...158,245,076
Ensembl chr 1:158,120,200...158,252,012

G

HEAT repeat containing 5B

decreases expression

nickel sulfate results in decreased expression of HEATR5B mRNA

NCBI chr 6:16,243,424...16,323,444
Ensembl chr 6:16,243,461...16,323,435

G

HECT and RLD domain containing E3 ubiquitin protein ligase 4

decreases expression

nickel sulfate results in decreased expression of HERC4 mRNA

NCBI chr20:25,329,972...25,404,657
Ensembl chr20:25,330,280...25,404,657

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

increases expression

nickel sulfate results in increased expression of HERC6 mRNA

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

G

hes family bHLH transcription factor 1

increases expression

nickel sulfate results in increased expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

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hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions
decreases expression
decreases hydroxylation
increases stability

nickel sulfate results in increased expression of HIF1A mRNA; nickel sulfate results in increased expression of HIF1A protein
[chromium hexavalent ion co-treated with nickel sulfate] results in increased expression of HIF1A protein; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in decreased expression of USP28 protein]; [HIF1A mRNA co-treated with EPAS1 mRNA] affects the reaction [nickel sulfate results in increased degradation of MYC protein]; [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in decreased expression of HIF1A mRNA; [nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of HIF1A protein; [potassium chromate(VI) co-treated with nickel sulfate] results in increased expression of HIF1A protein; [U 0126 co-treated with SB 203580] inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of HIF1A protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in decreased hydroxylation of HIF1A protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in increased expression of HIF1A protein]; Ascorbic Acid inhibits the reaction [nickel sulfate results in increased stability of HIF1A protein]; Dinoprostone promotes the reaction [nickel sulfate results in increased expression of and results in increased activity of HIF1A protein]; HIF1A mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PTGS2 mRNA]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PTGS2 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL1 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL5 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL8 protein]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of VEGFA protein]; HIF1A protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; macrophage stimulatory lipopeptide 2 co-treated with [nickel sulfate results in increased expression of HIF1A protein]; nickel sulfate affects the localization of and results in increased stability of HIF1A protein; nickel sulfate promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; nickel sulfate results in increased expression of and results in increased activity of HIF1A protein; SB 203580 inhibits the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of HIF1A protein]; U 0126 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of HIF1A protein]
nickel sulfate results in decreased expression of HIF1A mRNA

PMID:16288478 PMID:16314067 PMID:17382205 PMID:18832182 PMID:19074761 More...

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

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hypoxia inducible lipid droplet-associated

increases expression

nickel sulfate results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

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histidine triad nucleotide binding protein 3

increases expression

nickel sulfate results in increased expression of HINT3 mRNA

NCBI chr 1:27,035,936...27,045,799
Ensembl chr 1:27,035,905...27,047,721

G

huntingtin interacting protein 1

increases expression

nickel sulfate results in increased expression of HIP1 mRNA

NCBI chr12:21,133,364...21,267,796
Ensembl chr12:21,133,406...21,267,725

G

homeodomain interacting protein kinase 2

increases expression

nickel sulfate results in increased expression of HIPK2 mRNA

NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223

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HIVEP zinc finger 1

increases expression

nickel sulfate results in increased expression of HIVEP1 mRNA

PMID:16780908 PMID:22714537

NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956

G

hexokinase 2

decreases expression

nickel sulfate results in decreased expression of HK2 mRNA

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

increases expression

nickel sulfate results in increased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

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heme oxygenase 1

increases expression
decreases expression
multiple interactions

nickel sulfate results in increased expression of HMOX1 mRNA
nickel sulfate results in decreased expression of HMOX1 protein
Quercetin inhibits the reaction [nickel sulfate results in decreased expression of HMOX1 protein]

PMID:16314067 PMID:19033392 PMID:20146380 PMID:20491607 PMID:20566472 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

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heterogeneous nuclear ribonucleoprotein A1

increases expression

nickel sulfate results in increased expression of HNRNPA1 mRNA

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

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homer scaffold protein 1

increases expression

nickel sulfate results in increased expression of HOMER1 mRNA

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

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homeobox A1

increases expression

nickel sulfate results in increased expression of HOXA1 mRNA

NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504

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homeobox A2

increases expression

nickel sulfate results in increased expression of HOXA2 mRNA

NCBI chr 4:81,262,668...81,266,970
Ensembl chr 4:81,262,768...81,265,044

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homeobox A3

increases expression

nickel sulfate results in increased expression of HOXA3 mRNA

NCBI chr 4:81,269,243...81,313,218
Ensembl chr 4:81,269,243...81,313,218

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homeo box C10

increases expression

nickel sulfate results in increased expression of HOXC10 mRNA

NCBI chr 7:134,103,741...134,108,966
Ensembl chr 7:134,103,643...134,108,966

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homeobox C13

increases expression

nickel sulfate results in increased expression of HOXC13 mRNA

NCBI chr 7:134,058,640...134,065,479
Ensembl chr 7:134,058,640...134,064,800

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homeobox C9

increases expression

nickel sulfate results in increased expression of HOXC9 mRNA

NCBI chr 7:134,118,817...134,121,497
Ensembl chr 7:134,118,817...134,121,492

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hippocalcin-like 1

increases expression

nickel sulfate results in increased expression of HPCAL1 mRNA

NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687

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15-hydroxyprostaglandin dehydrogenase

decreases expression

nickel sulfate results in decreased expression of HPGD mRNA

NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228

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hypoxanthine phosphoribosyltransferase 1

affects expression

nickel sulfate affects the expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

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HPS5, biogenesis of lysosomal organelles complex 2 subunit 2

increases expression

nickel sulfate results in increased expression of HPS5 mRNA

NCBI chr 1:97,281,626...97,320,945
Ensembl chr 1:97,247,598...97,321,019

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heparan sulfate 6-O-sulfotransferase 1

increases expression

nickel sulfate results in increased expression of HS6ST1 mRNA

NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions
decreases expression

[CGA protein co-treated with nickel sulfate] results in decreased expression of HSD17B3 mRNA; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]; pyrazolanthrone inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]; U 0126 inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]

NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554

G

hydroxysteroid (17-beta) dehydrogenase 6

increases expression

nickel sulfate results in increased expression of HSD17B6 mRNA

NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425

G

hydroxysteroid (17-beta) dehydrogenase 7

multiple interactions

[nickel sulfate results in increased abundance of Nickel] which results in decreased expression of HSD17B7 mRNA

NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017

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hydroxysteroid dehydrogenase like 1

increases expression

nickel sulfate results in increased expression of HSDL1 mRNA

NCBI chr19:47,615,794...47,631,892
Ensembl chr19:47,615,796...47,631,846

G

heat shock transcription factor 1

increases expression

nickel sulfate results in increased expression of HSF1 mRNA

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein family A (Hsp70) member 12A

increases expression

nickel sulfate results in increased expression of HSPA12A mRNA

NCBI chr 1:257,935,642...258,096,602
Ensembl chr 1:257,935,644...258,096,846

G

heat shock protein family A (Hsp70) member 1A

increases expression

nickel sulfate results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]
nickel sulfate results in increased expression of HSPA5 mRNA; nickel sulfate results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

nickel sulfate results in increased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family B (small) member 8

increases expression

nickel sulfate results in increased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

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heparan sulfate proteoglycan 2

decreases expression

nickel sulfate results in decreased expression of HSPG2 mRNA

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

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HIV-1 Tat interactive protein 2

increases expression

nickel sulfate results in increased expression of HTATIP2 mRNA

NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629

G

5-hydroxytryptamine receptor 1D

increases expression

nickel sulfate results in increased expression of HTR1D mRNA

NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619

G

5-hydroxytryptamine receptor 7

decreases expression

nickel sulfate results in decreased expression of HTR7 mRNA

NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626

G

intercellular adhesion molecule 1

increases expression
affects expression

nickel sulfate results in increased expression of ICAM1 mRNA
nickel sulfate affects the expression of ICAM1 mRNA
nickel sulfate results in increased expression of ICAM1 protein

PMID:11114790 PMID:18202158 PMID:19702435 PMID:20417223 PMID:29540657

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

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inhibitor of DNA binding 1

increases expression

nickel sulfate results in increased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 2

increases expression

nickel sulfate results in increased expression of ID2 mRNA

PMID:16780908 PMID:20146380

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

inhibitor of DNA binding 3

increases expression

nickel sulfate results in increased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

inhibitor of DNA binding 4

increases expression

nickel sulfate results in increased expression of ID4 mRNA

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta

decreases expression

nickel sulfate results in decreased expression of IDH3B mRNA

NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982

G

indoleamine 2,3-dioxygenase 1

increases expression

nickel sulfate results in increased expression of IDO1 mRNA

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

iduronate 2-sulfatase

decreases expression

nickel sulfate results in decreased expression of IDS mRNA

NCBI chr X:149,025,976...149,046,641
Ensembl chr X:149,025,976...149,046,663

G

immediate early response 2

increases expression

nickel sulfate results in increased expression of IER2 mRNA

NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211

G

immediate early response 3

increases expression

nickel sulfate results in increased expression of IER3 mRNA

PMID:17374397 PMID:18651567 PMID:22714537

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

IFI30, lysosomal thiol reductase

increases expression

nickel sulfate results in increased expression of IFI30 mRNA

NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175

G

interferon-induced protein 44

increases expression

nickel sulfate results in increased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon induced with helicase C domain 1

increases expression

nickel sulfate results in increased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

interferon-induced protein with tetratricopeptide repeats 2

decreases expression

nickel sulfate results in decreased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon induced transmembrane protein 1

increases expression

nickel sulfate results in increased expression of IFITM1 mRNA

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

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interferon beta 1

increases expression

nickel sulfate results in increased expression of IFNB1 mRNA

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon, epsilon

decreases expression

nickel sulfate results in decreased expression of IFNE mRNA

NCBI chr 5:103,571,630...103,572,290
Ensembl chr 5:103,569,675...103,572,256

G

interferon gamma

multiple interactions
increases expression
affects expression
increases secretion

[nickel sulfate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Cholecalciferol inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Cyclosporine inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; Hydrocortisone inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]; IFNG protein promotes the reaction [nickel sulfate results in increased expression of IL27 mRNA]; Zinc Sulfate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]
nickel sulfate results in increased expression of IFNG mRNA
nickel sulfate affects the expression of IFNG mRNA

PMID:10929769 PMID:11145678 PMID:14650623 PMID:15270870 PMID:15663561 More...

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon-related developmental regulator 1

increases expression

nickel sulfate results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

intraflagellar transport 56

increases expression

nickel sulfate results in increased expression of IFT56 mRNA

NCBI chr 4:67,090,622...67,154,707
Ensembl chr 4:67,090,660...67,147,903

G

intraflagellar transport 70A2

increases expression

nickel sulfate results in increased expression of IFT70A mRNA

NCBI chr 3:60,899,193...60,901,634
Ensembl chr 3:60,899,196...60,901,634

G

intraflagellar transport 88

decreases expression

nickel sulfate results in decreased expression of IFT88 mRNA

NCBI chr15:31,573,325...31,666,068
Ensembl chr15:31,573,376...31,672,147

G

insulin-like growth factor 2 mRNA binding protein 1

decreases expression

nickel sulfate results in decreased expression of IGF2BP1 mRNA

NCBI chr10:80,908,300...80,951,097
Ensembl chr10:80,908,076...80,951,129

G

insulin-like growth factor binding protein 4

decreases expression

nickel sulfate results in decreased expression of IGFBP4 mRNA

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

insulin-like growth factor binding protein 6

decreases expression
increases expression

nickel sulfate results in decreased expression of IGFBP6 mRNA
nickel sulfate results in increased expression of IGFBP6 mRNA

PMID:16100012 PMID:16780908 PMID:17374397

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

interleukin 10

increases secretion
increases expression

nickel sulfate results in increased secretion of IL10 protein
nickel sulfate results in increased expression of IL10 mRNA

PMID:11145678 PMID:15347381

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 11

decreases expression

nickel sulfate results in decreased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

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interleukin 12A

increases expression

nickel sulfate results in increased expression of IL12A mRNA

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

affects expression
multiple interactions
increases secretion
increases expression

nickel sulfate affects the expression of IL12B mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [nickel sulfate results in increased secretion of IL12B protein]; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]
nickel sulfate results in increased expression of IL12B mRNA; nickel sulfate results in increased expression of IL12B protein

PMID:17636246 PMID:18202158 PMID:19101624 PMID:20525893 PMID:25673294 More...

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

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interleukin 13 receptor subunit alpha 1

increases expression

nickel sulfate results in increased expression of IL13RA1 mRNA

NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681

G

interleukin 15

affects expression

nickel sulfate affects the expression of IL15 mRNA

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 18

decreases expression
increases expression

nickel sulfate results in decreased expression of IL18 mRNA
nickel sulfate results in increased expression of IL18 protein

PMID:18651567 PMID:23063874

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

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interleukin 1 alpha

increases secretion
multiple interactions

nickel sulfate results in increased secretion of IL1A protein
IL1A protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]; IL1A protein affects the reaction [nickel sulfate results in increased secretion of CXCL8 protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

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interleukin 1 beta

increases expression
increases secretion
multiple interactions
decreases expression

nickel sulfate results in increased expression of IL1B mRNA
nickel sulfate results in increased secretion of IL1B protein
[Tetradecanoylphorbol Acetate co-treated with nickel sulfate] results in increased expression of and results in increased secretion of IL1B protein; Zinc Sulfate inhibits the reaction [nickel sulfate results in increased secretion of IL1B protein]
nickel sulfate results in increased expression of IL1B mRNA; nickel sulfate results in increased expression of IL1B protein
Quercetin inhibits the reaction [nickel sulfate results in increased expression of IL1B protein]
nickel sulfate results in decreased expression of IL1B mRNA

PMID:11033066 PMID:11114790 PMID:11751209 PMID:14650623 PMID:16166746 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

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interleukin 1 receptor type 1

increases expression

nickel sulfate results in increased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

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interleukin 1 receptor type 2

increases expression

nickel sulfate results in increased expression of IL1R2 mRNA

PMID:16166746 PMID:16780908

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

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interleukin 1 receptor antagonist

increases expression

nickel sulfate results in increased expression of IL1RN mRNA

PMID:16166746 PMID:16780908

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

increases secretion
increases expression
multiple interactions

nickel sulfate results in increased secretion of IL2 protein
nickel sulfate results in increased expression of IL2 protein
[nickel sulfate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA

PMID:12925207 PMID:22381623 PMID:29594315

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 23 subunit alpha

increases expression

nickel sulfate results in increased expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 24

decreases expression

nickel sulfate results in decreased expression of IL24 mRNA

NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487

G

interleukin 27

increases expression
multiple interactions

nickel sulfate results in increased expression of IL27 mRNA
BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of IL27 mRNA]; IFNG protein promotes the reaction [nickel sulfate results in increased expression of IL27 mRNA]; Janus Kinase Inhibitors inhibits the reaction [nickel sulfate results in increased secretion of IL27 mRNA]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of IL27 mRNA]; TLR4 protein affects the reaction [nickel sulfate results in increased expression of IL27 mRNA]

NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582

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interleukin 4

increases secretion
increases expression

nickel sulfate results in increased secretion of IL4 protein
nickel sulfate results in increased expression of IL4 mRNA

PMID:10929769 PMID:11145678

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

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interleukin 4 receptor

increases expression

nickel sulfate results in increased expression of IL4RA mRNA; nickel sulfate results in increased expression of IL4RA protein

PMID:16100012 PMID:22381623

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

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interleukin 5

multiple interactions
increases secretion

Cyclosporine inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]; Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]; Hydrocortisone inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]

PMID:10929769 PMID:15270870 PMID:15347381 PMID:15663561 PMID:19572476

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

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interleukin 6

increases expression
multiple interactions
increases secretion

nickel sulfate results in increased expression of IL6 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of IL6 mRNA; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of IL6 mRNA; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein; [Tetradecanoylphorbol Acetate co-treated with nickel sulfate] results in increased expression of and results in increased secretion of IL6 protein; BAY 11-7085 inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; HIF1A mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; nickel sulfate results in increased expression of and results in increased secretion of IL6 protein; PTGS2 mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased expression of IL6 protein]; pyrazolanthrone inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased secretion of IL6 protein]; U 0126 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; U 0126 inhibits the reaction [nickel sulfate results in increased expression of IL6 protein]
nickel sulfate results in increased expression of IL6 mRNA; nickel sulfate results in increased expression of IL6 protein
puerarin inhibits the reaction [nickel sulfate results in increased expression of IL6 protein]

PMID:11033066 PMID:11114790 PMID:16166746 PMID:16780908 PMID:17118622 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178