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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aureolic acid
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Accession:CHEBI:52513 term browser browse the term
Definition:Glycoside compounds that have a 1-keto-8,9-dihydroxyanthracene skeleton, a functionalized alkyl chain at the 3- position, and two oligosaccharide chains of variable lengths.
Synonyms:related_synonym: aureolic acids


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mithramycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP Plicamycin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA] CTD PMID:25398788 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression EXP Plicamycin results in decreased expression of ANKRD37 mRNA CTD PMID:23814049 NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963 		JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions
decreases expression		 EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of ATP7A mRNA]
Plicamycin results in decreased expression of ATP7A mRNA		 CTD PMID:23814049 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Axl Axl receptor tyrosine kinase decreases expression ISO Plicamycin results in decreased expression of AXL CTD PMID:18522535 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like multiple interactions
decreases expression		 EXP
ISO		 Plicamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BNIP3L mRNA]
Plicamycin results in decreased expression of BNIP3L mRNA		 CTD PMID:16291751 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]] CTD PMID:19593637 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Plicamycin inhibits the reaction [[Cyclosporine co-treated with NGF protein] results in increased expression of CDKN1A mRNA]; Plicamycin inhibits the reaction [SP1 protein binds to CDKN1A promoter] CTD PMID:24244623 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cybrd1 cytochrome b reductase 1 multiple interactions
decreases expression		 EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of CYBRD1 mRNA]
Plicamycin results in decreased expression of CYBRD1 mRNA		 CTD PMID:23814049 NCBI chr 3:55,934,874...55,962,132
Ensembl chr 3:55,934,874...55,962,108 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein] CTD PMID:17307335 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression EXP Plicamycin results in decreased expression of EPAS1 mRNA CTD PMID:23814049 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Plicamycin inhibits the reaction [Butyric Acid results in increased expression of ERN1 protein] CTD PMID:26784903 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]] CTD PMID:19593637 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
decreases expression		 ISO Plicamycin inhibits the reaction [Asbestos results in increased expression of F3 mRNA]
Plicamycin results in decreased expression of F3 mRNA		 CTD PMID:15636197 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO Plicamycin results in decreased expression of GATA4 protein CTD PMID:34087332 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Plicamycin inhibits the reaction [Butyric Acid results in increased expression of HSPA5 protein] CTD PMID:26784903 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Plicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] CTD PMID:18953428 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO Plicamycin inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA] CTD PMID:15946989 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO Plicamycin inhibits the reaction [[Cyclosporine co-treated with NGF protein] results in increased expression of CDKN1A mRNA] CTD PMID:24244623 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO Plicamycin results in decreased expression of PFKP mRNA CTD PMID:34087332 NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018 		JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions ISO Plicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] CTD PMID:18953428 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] CTD PMID:15690306 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon2 paraoxonase 2 multiple interactions ISO Plicamycin inhibits the reaction [Chlorpyrifos results in increased expression of PON2 mRNA] CTD PMID:24979751 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
decreases expression		 EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC11A2 mRNA]
Plicamycin results in decreased expression of SLC11A2 mRNA		 CTD PMID:23814049 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
multiple interactions		 EXP Plicamycin results in decreased expression of SLC40A1 mRNA
Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC40A1 mRNA]		 CTD PMID:23814049 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Sp1 Sp1 transcription factor decreases activity
multiple interactions
decreases expression		 ISO
EXP		 Plicamycin results in decreased activity of SP1 protein
[Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]; Plicamycin inhibits the reaction [SP1 protein binds to CDKN1A promoter]; Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]
Plicamycin results in decreased expression of SP1 mRNA
Plicamycin results in decreased expression of SP1 protein		 CTD PMID:15946989 PMID:17307335 PMID:21603612 PMID:23814049 PMID:24244623 More... NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tfrc transferrin receptor increases expression EXP Plicamycin results in increased expression of TFRC mRNA CTD PMID:23814049 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Plicamycin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA] CTD PMID:25398788 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein; Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter] CTD PMID:21603612 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 decreases expression ISO Plicamycin results in decreased expression of TNIP1 mRNA CTD PMID:23464785 NCBI chr10:39,037,048...39,084,328
Ensembl chr10:39,037,058...39,077,625 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression ISO Mithramycin A decreases expression of XRCC1 mRNA in lung and liver cancer and liver cancer cell lines RGD PMID:30088263 RGD:15036795 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          oxygen atom 19541
            oxygen molecular entity 19541
              organooxygen compound 19191
                polyketide 11519
                  decaketide 32
                    aureolic acid 32
                      chromomycin + 0
                      durhamycin A 0
                      durhamycin B 0
                      mithramycin 32
                      olivomycin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbohydrates and carbohydrate derivatives 15289
                                    carbohydrate 15289
                                      carbohydrate derivative 14305
                                        glycosyl compound 13067
                                          glycoside 11835
                                            aureolic acid 32
                                              chromomycin + 0
                                              durhamycin A 0
                                              durhamycin B 0
                                              mithramycin 32
                                              olivomycin + 0
paths to the root