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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aureolic acid
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Accession:CHEBI:52513 term browser browse the term
Definition:Glycoside compounds that have a 1-keto-8,9-dihydroxyanthracene skeleton, a functionalized alkyl chain at the 3- position, and two oligosaccharide chains of variable lengths.
Synonyms:related_synonym: aureolic acids


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mithramycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP Plicamycin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA] CTD PMID:25398788 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression EXP Plicamycin results in decreased expression of ANKRD37 mRNA CTD PMID:23814049 NCBI chr16:53,001,487...53,004,545
Ensembl chr16:52,994,740...53,004,545 		JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions
decreases expression 		EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of ATP7A mRNA]
Plicamycin results in decreased expression of ATP7A mRNA 		CTD PMID:23814049 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:75,159,782...75,267,093 		JBrowse link
G Axl Axl receptor tyrosine kinase decreases expression ISO Plicamycin results in decreased expression of AXL CTD PMID:18522535 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like multiple interactions
decreases expression 		EXP
ISO 		Plicamycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BNIP3L mRNA]
Plicamycin results in decreased expression of BNIP3L mRNA 		CTD PMID:16291751 NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]] CTD PMID:19593637 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Plicamycin inhibits the reaction [[Cyclosporine co-treated with NGF protein] results in increased expression of CDKN1A mRNA]; Plicamycin inhibits the reaction [SP1 protein binds to CDKN1A promoter] CTD PMID:24244623 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cybrd1 cytochrome b reductase 1 multiple interactions
decreases expression 		EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of CYBRD1 mRNA]
Plicamycin results in decreased expression of CYBRD1 mRNA 		CTD PMID:23814049 NCBI chr 3:76,342,231...76,369,846
Ensembl chr 3:76,342,404...76,370,061 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein] CTD PMID:17307335 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037 		JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression EXP Plicamycin results in decreased expression of EPAS1 mRNA CTD PMID:23814049 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Plicamycin inhibits the reaction [Butyric Acid results in increased expression of ERN1 protein] CTD PMID:26784903 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Plicamycin inhibits the reaction [afimoxifene promotes the reaction [ESR1 protein binds to CDH1 promoter]] CTD PMID:19593637 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
decreases expression 		ISO Plicamycin inhibits the reaction [Asbestos results in increased expression of F3 mRNA]
Plicamycin results in decreased expression of F3 mRNA 		CTD PMID:15636197 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO Plicamycin results in decreased expression of GATA4 protein CTD PMID:34087332 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Plicamycin inhibits the reaction [Butyric Acid results in increased expression of HSPA5 protein] CTD PMID:26784903 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Plicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] CTD PMID:18953428 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO Plicamycin inhibits the reaction [Dexamethasone results in increased expression of MAOA mRNA] CTD PMID:15946989 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO Plicamycin inhibits the reaction [[Cyclosporine co-treated with NGF protein] results in increased expression of CDKN1A mRNA] CTD PMID:24244623 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Pfkp phosphofructokinase, platelet decreases expression ISO Plicamycin results in decreased expression of PFKP mRNA CTD PMID:34087332 NCBI chr17:68,639,749...68,704,055
Ensembl chr17:68,639,481...68,705,752 		JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions ISO Plicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] CTD PMID:18953428 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] CTD PMID:15690306 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Pon2 paraoxonase 2 multiple interactions ISO Plicamycin inhibits the reaction [Chlorpyrifos results in increased expression of PON2 mRNA] CTD PMID:24979751 NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:34,356,274...34,391,996 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] CTD PMID:20160399 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
decreases expression 		EXP Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC11A2 mRNA]
Plicamycin results in decreased expression of SLC11A2 mRNA 		CTD PMID:23814049 NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression
multiple interactions 		EXP Plicamycin results in decreased expression of SLC40A1 mRNA
Plicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC40A1 mRNA] 		CTD PMID:23814049 NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460 		JBrowse link
G Sp1 Sp1 transcription factor decreases activity
multiple interactions
decreases expression 		ISO
EXP 		Plicamycin results in decreased activity of SP1 protein
[Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; [Plicamycin results in decreased activity of SP1 protein] inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]; Plicamycin inhibits the reaction [SP1 protein binds to CDKN1A promoter]; Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]
Plicamycin results in decreased expression of SP1 mRNA
Plicamycin results in decreased expression of SP1 protein 		CTD PMID:15946989 PMID:17307335 PMID:21603612 PMID:23814049 PMID:24244623 More... NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513 		JBrowse link
G Tfrc transferrin receptor increases expression EXP Plicamycin results in increased expression of TFRC mRNA CTD PMID:23814049 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Plicamycin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA] CTD PMID:25398788 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein; Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter] CTD PMID:21603612 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 decreases expression ISO Plicamycin results in decreased expression of TNIP1 mRNA CTD PMID:23464785 NCBI chr10:39,537,759...39,585,038
Ensembl chr10:39,537,437...39,585,158 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression ISO Mithramycin A decreases expression of XRCC1 mRNA in lung and liver cancer and liver cancer cell lines RGD PMID:30088263 RGD:15036795 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      atom 20872
        nonmetal atom 20781
          oxygen atom 20437
            oxygen molecular entity 20437
              organooxygen compound 19713
                polyketide 10698
                  decaketide 32
                    aureolic acid 32
                      chromomycin + 0
                      durhamycin A 0
                      durhamycin B 0
                      iso-mithramycin 0
                      mithramycin 32
                      mithramycin DK 0
                      olivomycin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbohydrates and carbohydrate derivatives 15263
                                    carbohydrate derivative 14522
                                      glycosyl compound 13128
                                        glycoside 12247
                                          aureolic acid 32
                                            chromomycin + 0
                                            durhamycin A 0
                                            durhamycin B 0
                                            iso-mithramycin 0
                                            mithramycin 32
                                            mithramycin DK 0
                                            olivomycin + 0
paths to the root