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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine
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Accession:CHEBI:52450 term browser browse the term
Definition:A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has octadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.
Synonyms:exact_synonym: (2R)-2-acetoxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate;   (2RR)-2-acetoxy-3-(octadecyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
 related_synonym: (-)-1-O-octadeyl-2-O-acetyl-sn-glycerylphosphocholine;   (R)-7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptaconasan-1-aminium hydroxide inner salt 4-oxide;   1-0-octadecyl 2-0-acetyl sn-glycero-3-phosphorylcholine;   1-O-Octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-Octadecyl-platelet-activating factor;   1-O-Stearoyl-2-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-Stearyl-2-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphorylcholine;   1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine;   1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine;   1-O-octadecyl-PAF;   1-octadecyl-2-acetyl-sn-glycero-3-phosphocholine;   AGEPC;   Blood platelet activating factor-aether;   Blood platelet-activating factor;   C18-PAF-acether;   C18-Paf;   C18:0 PAF;   Formula=C28H58NO7P;   InChI=1S/C28H58NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h28H,6-26H2,1-5H3/t28-/m1/s1;   InChIKey=ZXCIEWBDUAPBJF-MUUNZHRXSA-N;   PAF;   PAF-acether;   PC(O-18:0/2:0);   Ro 14-8161;   SMILES=P(OC[C@@H](COCCCCCCCCCCCCCCCCCC)OC(C)=O)(=O)(OCC[N+](C)(C)C)[O-];   acetyl-glyceryl-ether-phosphorylcholine;   blood platelet activating factor-acether;   phosphatidylcholine (O-18:0/2:0);   platelet activating factor;   platelet activating factor-acether
 alt_id: CHEBI:26164;   CHEBI:52390;   CHEBI:75217
 xref: Beilstein:5364572;   CAS:74389-69-8;   DrugBank:DB02261;   LIPID_MAPS_instance:LMGP01020094;   Reaxys:5364572;   Wikipedia:Platelet-activating_factor


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2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor increases expression EXP platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasma RGD PMID:10452877 RGD:38508900 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            bronchoconstrictor agent 67
              2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      chalcogen 19563
                        oxygen atom 19535
                          oxygen molecular entity 19535
                            hydroxides 19341
                              oxoacid 18777
                                pnictogen oxoacid 14974
                                  phosphorus oxoacid 14577
                                    phosphoric acids 13926
                                      phosphoric acid 13926
                                        phosphoric acid derivative 13835
                                          phosphate 13834
                                            organic phosphate 13834
                                              phospholipid 322
                                                glycerophospholipid 218
                                                  glycerophosphocholine 124
                                                    alkylacylglycero-3-phosphocholine 33
                                                      alkyl,acyl-sn-glycero-3-phosphocholine 33
                                                        2-acyl-1-alkyl-sn-glycero-3-phosphocholine 33
                                                          2-acetyl-1-alkyl-sn-glycero-3-phosphocholine 33
                                                            2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine 1
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