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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:wortmannin
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Accession:CHEBI:52289 term browser browse the term
Definition:A delta-lactone that has formula C23H24O8.
Synonyms:exact_synonym: (1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
 related_synonym: Formula=C23H24O8;   InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1;   InChIKey=QDLHCMPXEPAAMD-QAIWCSMKSA-N;   SMILES=[H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)C2=C3C(=CO2)C(=O)O[C@H](COC)[C@]13C;   Wartmannin
 alt_id: CHEBI:43674
 xref: CAS:19545-26-7;   DrugBank:DB08059;   HMDB:HMDB0259902;   KEGG:C15181;   KNApSAcK:C00023672;   LINCS:LSM-3947
 xref_mesh: MESH:C009687
 xref: MetaCyc:CPD-11924;   PDBeChem:KWT;   PMID:11090628;   PMID:18703838;   PMID:19805105;   PMID:20017609;   PMID:22003059;   PMID:22056625;   PMID:22524784;   PMID:25449276;   PMID:27375631;   PMID:28000865;   PMID:28474885;   PMID:30036994;   PMID:32052028;   PMID:34306363;   Reaxys:67676;   Wikipedia:Wortmannin


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wortmannin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 affects localization
decreases activity
multiple interactions		 EXP
ISO		 wortmannin affects the localization of ABCB11 protein
wortmannin results in decreased activity of ABCB11 protein
wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]		 CTD PMID:12702492 PMID:20815017 PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects localization
multiple interactions		 EXP wortmannin affects the localization of ABCC2 protein
Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]		 CTD PMID:12702492 PMID:20815017 PMID:31300867 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP wortmannin inhibits the reaction [bisphenol A results in decreased expression of ACOX1 mRNA] CTD PMID:23399309 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Wortmannin inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Wortmannin inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Wortmannin inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] CTD PMID:15121739 PMID:15849355 PMID:25398788 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of AHR mRNA] CTD PMID:26466350 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases localization EXP wortmannin results in decreased localization of AIFM1 protein CTD PMID:21256120 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases reaction
decreases phosphorylation
decreases activity
decreases expression		 ISO
EXP		 AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; Wortmannin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [baicalein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [CXCL8 results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Estrone results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Hexanones results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Humic Substances results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Hydrocarbons, Chlorinated results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [ochratoxin A results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Trp-Lys-Tyr-Met-Val-Met results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin promotes the reaction [evodiamine results in decreased phosphorylation of AKT1 protein]
Wortmannin inhibits the reaction [ethanol increases phosphorylation of Akt1 protein in cardiac muscle cells]
Wortmannin inhibits the reaction [Insulin increases activity of Akt1 protein in adipocytes]
wortmannin inhibits the reaction [estrogen increases phosphorylation of Akt1 protein] in rat uterus
wortmannin results in decreased phosphorylation of AKT1 protein
wortmannin results in decreased activity of AKT1 protein
Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [astringin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [hydroxyflutamide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [linsidomine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]]; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Taurocholic Acid inhibits the reaction [Carbon Tetrachloride results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]
wortmannin results in decreased expression of AKT1 protein
Wortmannin results in decreased phosphorylation of AKT1 protein
Resveratrol promotes the reaction [Wortmannin results in decreased phosphorylation of AKT1 protein]; Thimerosal promotes the reaction [Wortmannin results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4-hydroxyisoleucine inhibits the reaction [TNF protein results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [zinc chloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Wortmannin promotes the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Thimerosal results in decreased phosphorylation of AKT1 protein]; Wortmannin results in decreased activity of and results in decreased phosphorylation of AKT1 protein		 CTD
RGD		 PMID:11306697 PMID:11340092 PMID:11788791 PMID:12032135 PMID:12388182 More... RGD:408346755, RGD:407420264, RGD:152177689 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt1s1 AKT1 substrate 1 multiple interactions
decreases phosphorylation		 ISO wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1S1 protein]
wortmannin results in decreased phosphorylation of AKT1S1 protein		 CTD PMID:20880397 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions
increases activity		 ISO wortmannin promotes the reaction [Methotrexate results in increased activity of ALPI protein]
wortmannin results in increased activity of ALPI protein		 CTD PMID:16598758 NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877 		JBrowse link
G Apob apolipoprotein B multiple interactions EXP wortmannin inhibits the reaction [[bisphenol A results in decreased expression of APOB mRNA] which results in decreased abundance of Triglycerides]; wortmannin inhibits the reaction [bisphenol A results in decreased expression of APOB mRNA] CTD PMID:23399309 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Areg amphiregulin decreases activity EXP wortmannin results in decreased activity of AREG protein CTD PMID:12589827 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions EXP wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of ARNT mRNA] CTD PMID:26466350 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions EXP Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of ATF2 protein] CTD PMID:10611455 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of ATM protein]
ATM protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene]		 CTD PMID:15489221 PMID:20888899 PMID:22119920 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases phosphorylation		 ISO
EXP		 wortmannin inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of BAD protein]
wortmannin results in decreased phosphorylation of BAD protein
Wortmannin inhibits the reaction [Mannitol results in increased phosphorylation of BAD protein]; Wortmannin inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and affects the localization of BAD protein]		 CTD PMID:15190125 PMID:15608143 PMID:15786717 PMID:19596284 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP		 Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; Wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of BAX protein]]		 CTD PMID:15142122 PMID:15970427 PMID:31173752 PMID:32805344 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member multiple interactions ISO [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]; wortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of BCAR1 protein] CTD PMID:10537051 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 Wortmannin inhibits the reaction [[Hydrogen Peroxide co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein]; Wortmannin inhibits the reaction [Ethanol results in increased expression of BCL2 protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of BCL2 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]
Wortmannin inhibits the reaction [[1,1-dimethylbutyl-1-deoxy-Delta(9)-THC co-treated with Magnesium deficiency] results in increased expression of BCL2 protein]; Wortmannin inhibits the reaction [Propofol results in increased expression of BCL2 protein]		 CTD PMID:15142122 PMID:19703415 PMID:21410490 PMID:30542433 PMID:31173752 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]] CTD PMID:15142122 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO
EXP		 wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of BDNF protein]]		 CTD PMID:17209049 PMID:32805344 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions
decreases expression		 ISO
EXP		 wortmannin promotes the reaction [Ethanol results in increased degradation of BECN1 protein]
wortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein]
wortmannin results in decreased expression of BECN1 protein		 CTD PMID:21410490 PMID:23604964 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression		 ISO wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC2 protein]
wortmannin results in decreased expression of BIRC2 mRNA; wortmannin results in decreased expression of BIRC2 protein		 CTD PMID:15065019 PMID:19596284 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC3 protein] CTD PMID:19596284 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions		 ISO wortmannin results in decreased expression of BIRC5 mRNA; wortmannin results in decreased expression of BIRC5 protein
wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein]
wortmannin promotes the reaction [resveratrol results in decreased expression of BIRC5 protein]		 CTD PMID:15065019 PMID:18025287 PMID:22137261 PMID:23145070 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G C5 complement C5 multiple interactions ISO wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA]; wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein] CTD PMID:16116186 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Casp1 caspase 1 increases cleavage ISO wortmannin results in increased cleavage of CASP1 protein CTD PMID:26847702 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
decreases activity		 ISO
EXP		 ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP3 protein]
wortmannin results in increased cleavage of CASP3 protein
[Rotenone co-treated with wortmannin] results in increased cleavage of CASP3 protein; Thimerosal promotes the reaction [wortmannin results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [resveratrol results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [Thimerosal results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [wortmannin results in increased cleavage of CASP3 protein]
wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP3 protein]
wortmannin results in decreased activity of CASP3 protein		 CTD PMID:15142122 PMID:15695173 PMID:17935137 PMID:20104024 PMID:21256120 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP7 protein] CTD PMID:25002221 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO
EXP		 ABT-737 promotes the reaction [wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]
wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP8 protein]		 CTD PMID:20104024 PMID:24726520 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO
EXP		 ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]
wortmannin results in increased cleavage of CASP9 protein
Thimerosal promotes the reaction [wortmannin results in increased cleavage of CASP9 protein]; wortmannin promotes the reaction [Thimerosal results in increased cleavage of CASP9 protein]
wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP9 protein]		 CTD PMID:17935137 PMID:20104024 PMID:22137261 PMID:23145070 PMID:24726520 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to Hydrogen Peroxide]; wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to sodium arsenite] CTD PMID:12640124 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:22225513 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA] CTD PMID:19016906 PMID:22225513 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO wortmannin inhibits the reaction [Vanadates results in increased expression of CCNA2 protein] CTD PMID:14971663 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNB1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNB1 protein] CTD PMID:26385184 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO
EXP		 Wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]; Wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of CCND1 mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of CCND1 protein]
Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of CCND1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of CCND1 mRNA]
Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased expression of CCND1 protein]]; Wortmannin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CCND1 protein]
wortmannin results in decreased expression of CCND1 protein		 CTD PMID:15695173 PMID:18353414 PMID:19801633 PMID:28321046 PMID:30542433 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 decreases methylation
increases expression		 ISO wortmannin results in decreased methylation of CCND2 promoter
wortmannin results in increased expression of CCND2 mRNA		 CTD PMID:14745455 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 affects localization
multiple interactions		 ISO wortmannin affects the localization of CCND3 protein
[wortmannin co-treated with Imatinib Mesylate] affects the localization of CCND3 protein; wortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein]		 CTD PMID:10849422 PMID:17129604 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO wortmannin inhibits the reaction [Vanadates results in increased expression of CCNE1 protein]
[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]		 CTD PMID:14971663 PMID:26385184 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions ISO wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide] CTD PMID:19016906 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA] CTD PMID:19640849 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdc25a cell division cycle 25A multiple interactions
decreases expression		 ISO Imatinib Mesylate promotes the reaction [wortmannin results in decreased expression of CDC25A protein] CTD PMID:17129604 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdc5l cell division cycle 5-like multiple interactions EXP wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]] CTD PMID:20629186 NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO wortmannin results in increased expression of CDH1 protein CTD PMID:25856345 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CDH2 protein]; Wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CDH2 protein] CTD PMID:28163245 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; wortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein] CTD PMID:18025287 PMID:26385184 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
multiple interactions
decreases expression		 ISO wortmannin results in decreased activity of CDK2 protein
[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein]
wortmannin results in decreased expression of CDK2 protein		 CTD PMID:17129604 PMID:26385184 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of CDK4 protein] CTD PMID:36288207 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
increases expression		 ISO wortmannin inhibits the reaction [Aspirin results in increased expression of CDKN1A protein]; wortmannin inhibits the reaction [docetaxel results in increased expression of CDKN1A protein]
wortmannin results in decreased expression of CDKN1A protein
wortmannin results in increased expression of CDKN1A protein		 CTD PMID:15695173 PMID:17129604 PMID:20878124 PMID:21617849 PMID:22290291 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression		 ISO wortmannin promotes the reaction [Doxorubicin results in increased expression of CDKN1B protein]; wortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein]
Imatinib Mesylate promotes the reaction [wortmannin results in increased expression of CDKN1B protein]		 CTD PMID:17129604 PMID:17935137 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO wortmannin inhibits the reaction [CGP 12177 results in increased activity of CFTR protein] CTD PMID:15563584 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
decreases expression		 ISO wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein]
wortmannin results in decreased expression of CHEK1 protein		 CTD PMID:19261750 PMID:22119920 PMID:22409540 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
decreases phosphorylation		 ISO wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK2 protein]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK2 protein]
wortmannin results in decreased phosphorylation of CHEK2 protein		 CTD PMID:19111594 PMID:22119920 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ckb creatine kinase B decreases reaction EXP wortmannin inhibits the reaction [estrogen increases expression of Ckb mRNA] in rat uterus RGD PMID:17272396 RGD:152177689 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Clu clusterin multiple interactions ISO wortmannin inhibits the reaction [Zinc results in increased expression of CLU protein] CTD PMID:19288494 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain multiple interactions ISO wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]; wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein] CTD PMID:13679210 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO wortmannin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] CTD PMID:11343241 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP wortmannin inhibits the reaction [bisphenol A results in decreased expression of CPT1A mRNA] CTD PMID:23399309 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein]
wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CREB1 protein]]		 CTD PMID:15608143 PMID:22952890 PMID:23626723 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crp C-reactive protein multiple interactions ISO wortmannin inhibits the reaction [Dust analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Dust results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Particulate Matter analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Particulate Matter results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Vehicle Emissions analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Vehicle Emissions results in increased expression of CRP mRNA] CTD PMID:16263508 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein] CTD PMID:23001822 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
increases phosphorylation
multiple interactions		 ISO wortmannin results in decreased expression of CTNNB1 protein
wortmannin results in increased phosphorylation of CTNNB1 protein
wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTNNB1 protein]; wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CTNNB1 protein]; wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CTNNB1 protein]		 CTD PMID:11739494 PMID:28163245 PMID:28321046 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL1 protein] CTD PMID:20117814 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO
EXP		 wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of BAD protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein]
wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL2 protein]		 CTD PMID:15608143 PMID:20117814 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO wortmannin inhibits the reaction [CXCL8 protein results in increased activity of CXCR2 protein] CTD PMID:12975484 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cycs cytochrome c, somatic decreases secretion EXP wortmannin results in decreased secretion of CYCS protein CTD PMID:21256120 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA] CTD PMID:25253736 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP
ISO		 wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A1 mRNA]
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]		 CTD PMID:26466350 PMID:29724254 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A2 mRNA] CTD PMID:26466350 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions EXP
ISO		 wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1B1 mRNA]
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]		 CTD PMID:26466350 PMID:29724254 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO		 wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]
Wortmannin inhibits the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; Wortmannin inhibits the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]		 CTD PMID:11306697 PMID:22486562 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein] CTD PMID:17171638 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA] CTD PMID:28321046 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein] CTD PMID:23626723 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein] CTD PMID:23626723 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dnmt3l DNA methyltransferase 3 like multiple interactions ISO wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein] CTD PMID:23626723 NCBI chr20:10,614,933...10,629,337
Ensembl chr20:10,614,934...10,629,516 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO wortmannin inhibits the reaction [Vanadates results in increased expression of E2F1 protein] CTD PMID:14971663 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]] CTD PMID:12839867 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 multiple interactions
increases expression		 ISO [Wortmannin co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of EEF1A2 protein
Wortmannin results in increased expression of EEF1A2 protein		 CTD PMID:37051183 NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP		 [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein]
Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose]		 CTD PMID:15691865 PMID:15849355 PMID:25856345 PMID:26385184 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of EGFR mRNA]
wortmannin inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]		 CTD PMID:15177934 PMID:21568938 PMID:25856345 PMID:36190352 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of EIF4EBP1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of EIF4EBP1 protein modified form] CTD PMID:12569580 PMID:20936651 PMID:32802178 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of ELK1 mRNA] CTD PMID:36190352 PMID:37992829 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Epor erythropoietin receptor multiple interactions ISO wortmannin inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA] CTD PMID:20189893 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257 		JBrowse link
G Esr1 estrogen receptor 1 decreases reaction EXP wortmannin inhibits the reaction [estrogen increases expression of Esr1 mRNA] in rat uterus RGD PMID:17272396 RGD:152177689 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO wortmannin promotes the reaction [Histamine results in increased expression of F3] CTD PMID:16009787 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO Wortmannin affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions ISO wortmannin inhibits the reaction [evodiamine results in increased expression of FASLG protein] CTD PMID:20005289 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases activity
multiple interactions		 ISO
EXP		 wortmannin results in decreased activity of FGF1 protein
wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]		 CTD PMID:15121739 PMID:15695173 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA] CTD PMID:15803460 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FKBP1A mRNA] CTD PMID:36190352 PMID:37992829 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Flna filamin A multiple interactions ISO wortmannin inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein] CTD PMID:25944616 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand multiple interactions ISO wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein] CTD PMID:23001822 NCBI chr 1:95,615,056...95,620,463
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO		 wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA]
Wortmannin inhibits the reaction [Dieldrin results in increased expression of FOS mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS protein]		 CTD PMID:11687581 PMID:31068361 PMID:33582643 PMID:36190352 PMID:37992829 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO wortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Copper affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Copper Sulfate affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [INS protein results in increased expression of FOXO1 protein modified form]; wortmannin inhibits the reaction [Zinc affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Zinc Sulfate affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO1 protein]
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOXO1 mRNA]		 CTD PMID:16973122 PMID:17935137 PMID:20936651 PMID:24024143 PMID:37992829 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
decreases phosphorylation		 ISO Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO3 protein modified form]
wortmannin results in decreased phosphorylation of FOXO3 protein		 CTD PMID:17935137 PMID:20936651 PMID:23673518 PMID:24024143 PMID:25856345 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Foxo4 forkhead box O4 multiple interactions ISO wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO4 protein] CTD PMID:16973122 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115 		JBrowse link
G Foxp1 forkhead box P1 decreases expression ISO wortmannin results in decreased expression of FOXP1 protein CTD PMID:25663935 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of STAR mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; wortmannin inhibits the reaction [FSHB protein results in increased expression of STAR mRNA] CTD PMID:25253736 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FSHR mRNA] CTD PMID:37992829 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO wortmannin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA] CTD PMID:23829535 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression
multiple interactions		 ISO Wortmannin results in increased expression of G6PC1 mRNA
Wortmannin inhibits the reaction [INS protein results in decreased expression of G6PC1 mRNA]		 CTD PMID:24535192 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gast gastrin decreases secretion EXP wortmannin results in decreased secretion of GAST protein CTD PMID:19208342 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]] CTD PMID:34077701 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO wortmannin results in increased expression of GDF15 protein CTD PMID:23178381 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP wortmannin inhibits the reaction [hydroxyflutamide results in decreased expression of GJA1 protein] CTD PMID:26437446 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions EXP wortmannin inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein] CTD PMID:22925809 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in decreased expression of GNRH1 mRNA] CTD PMID:37992829 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of GPER1 mRNA] CTD PMID:36190352 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions EXP wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of GSK3B protein]; wortmannin promotes the reaction [GRK2 protein promotes the reaction [GRK2 protein binds to PIK3CG protein]] CTD PMID:28759639 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grn granulin precursor multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]; U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]; wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]; wortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein] CTD PMID:21820214 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions ISO Wortmannin inhibits the reaction [sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]] CTD PMID:25769802 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation
decreases expression		 ISO
EXP		 Wortmannin affects the reaction [sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]]; Wortmannin inhibits the reaction [Bortezomib results in decreased activity of and results in increased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of GSK3B protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]
wortmannin results in decreased phosphorylation of GSK3B protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]; wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of GSK3B protein]; wortmannin inhibits the reaction [rosiglitazone results in increased phosphorylation of GSK3B protein]
wortmannin results in decreased expression of GSK3B protein modified form
Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]; Vitamin E inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]; wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]		 CTD PMID:12614848 PMID:15842767 PMID:16076840 PMID:17513037 PMID:18040759 More... NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]; Wortmannin inhibits the reaction [Decitabine results in increased expression of H2AX protein]; Wortmannin promotes the reaction [Docetaxel results in increased expression of H2AX protein]; Wortmannin promotes the reaction [Soil Pollutants results in increased phosphorylation of H2AX protein] CTD PMID:17991895 PMID:20878124 PMID:22409540 PMID:34784199 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases reaction
decreases expression		 ISO
EXP		 [wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein]; wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]
wortmannin inhibits the reaction [estrogen increases expression of Hif1a mRNA] in rat uterus
wortmannin results in decreased expression of HIF1A protein		 CTD
RGD		 PMID:11424089 PMID:13679210 PMID:14726529 PMID:15050414 PMID:16499871 More... RGD:152177689 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO wortmannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and affects the localization of HMGB1 protein] CTD PMID:19265175 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP		 Wortmannin inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]
Wortmannin inhibits the reaction [astringin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Resveratrol results in increased expression of HMOX1 protein]
Wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [hydroquinone results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [quinone results in increased expression of HMOX1 protein]		 CTD PMID:17535857 PMID:18048804 PMID:20028456 PMID:20117814 PMID:22022464 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsf1 heat shock transcription factor 1 affects localization
multiple interactions		 ISO wortmannin affects the localization of HSF1 protein
wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]		 CTD PMID:11424089 PMID:20090934 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO wortmannin results in decreased expression of HSPA1A protein; wortmannin results in decreased expression of HSPA1A protein alternative form CTD PMID:20090934 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA] CTD PMID:19428936 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP
ISO		 wortmannin inhibits the reaction [resveratrol results in decreased activity of ICAM1 protein]
wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]		 CTD PMID:20117814 PMID:23114885 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA] CTD PMID:16399790 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifng interferon gamma multiple interactions ISO wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] CTD PMID:16968468 PMID:25352548 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO
EXP		 [wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]; wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]]
wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]		 CTD PMID:12569580 PMID:14745455 PMID:16499871 PMID:16682453 PMID:17520698 More... NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf2 insulin-like growth factor 2 decreases response to substance
multiple interactions		 ISO wortmannin results in decreased susceptibility to IGF2 protein
wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]		 CTD PMID:24055520 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; Wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16116186 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16116186 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA] CTD PMID:17982072 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO wortmannin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein] CTD PMID:15178407 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:16968468 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]; wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]		 CTD PMID:16359550 PMID:22952890 PMID:25352548 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO wortmannin results in decreased expression of IL1RN mRNA CTD PMID:26847702 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA] CTD PMID:16116186 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il3 interleukin 3 multiple interactions ISO Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]; Wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] CTD PMID:11544337 PMID:23001822 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of and results in increased secretion of IL4 protein]; Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 mRNA] CTD PMID:10611455 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 wortmannin inhibits the reaction [resveratrol results in decreased activity of IL6 protein]
[4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]
wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]		 CTD PMID:20117814 PMID:24631921 PMID:30217479 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO
EXP		 Wortmannin inhibits the reaction [BLX 1002 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Wortmannin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased expression of SORT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1S1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of NDRG1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased transport of Sodium]; Wortmannin inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Wortmannin inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]]; Wortmannin inhibits the reaction [Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]
Wortmannin inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of AHR mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of ARNT mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A1 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A2 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1B1 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased uptake of 2-(methylamino)isobutyric acid]		 CTD PMID:9877156 PMID:11306697 PMID:15172182 PMID:17962351 PMID:18591783 More... NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO
EXP		 [Wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; Wortmannin inhibits the reaction [INS protein results in decreased expression of G6PC1 mRNA]; Wortmannin inhibits the reaction [INS protein results in decreased susceptibility to Coumaric Acids]; Wortmannin inhibits the reaction [INS protein results in increased expression of EIF4EBP1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO3 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK3 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]
wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]		 CTD PMID:11574405 PMID:17550345 PMID:17728140 PMID:20015842 PMID:20936651 More... NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor multiple interactions EXP Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]] CTD PMID:32805344 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 decreases expression ISO wortmannin results in decreased expression of IRAK3 mRNA CTD PMID:26847702 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO
EXP		 wortmannin inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA]]		 CTD PMID:20936651 PMID:32805344 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] CTD PMID:15213856 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] CTD PMID:15213856 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740 		JBrowse link
G Kitlg KIT ligand multiple interactions ISO wortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein]; wortmannin inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein]
wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]		 CTD PMID:10849422 PMID:23001822 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions EXP wortmannin inhibits the reaction [Estradiol results in increased expression of KLF4 protein] CTD PMID:21484412 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Klf6 KLF transcription factor 6 decreases expression
multiple interactions		 ISO Wortmannin results in decreased expression of KLF6 mRNA
Wortmannin inhibits the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; Wortmannin inhibits the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]		 CTD PMID:22486562 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Kng1 kininogen 1 multiple interactions EXP KNG1 protein inhibits the reaction [[Wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; Wortmannin inhibits the reaction [KNG1 protein results in increased phosphorylation of PTK2 protein] CTD PMID:10537051 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lat2 linker for activation of T cells family, member 2 multiple interactions ISO wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein] CTD PMID:23001822 NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288 		JBrowse link
G Lep leptin decreases expression
multiple interactions
decreases secretion		 ISO wortmannin results in decreased expression of LEP mRNA
wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium]
wortmannin results in decreased secretion of LEP protein		 CTD PMID:19254925 PMID:20107083 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of LHR mRNA] CTD PMID:37992829 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521 		JBrowse link
G Lig1 DNA ligase 1 multiple interactions ISO wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein] CTD PMID:16700562 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
decreases expression		 ISO wortmannin inhibits the reaction [Rotenone results in increased expression of MAP1LC3B protein]
wortmannin results in decreased expression of MAP1LC3B protein		 CTD PMID:26847702 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO
EXP		 [bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; KN 93 promotes the reaction [Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; Wortmannin inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK1 protein modified form]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [ON123300 results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK1 mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]; Wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; Wortmannin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein]
Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of MAPK1 protein]
wortmannin results in decreased phosphorylation of MAPK1 protein
wortmannin results in increased phosphorylation of MAPK1 protein
Wortmannin affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]		 CTD PMID:10611455 PMID:15086530 PMID:15177934 PMID:15355987 PMID:15608143 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO wortmannin promotes the reaction [Tretinoin results in increased phosphorylation of MAPK14 protein] CTD PMID:12032135 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO
EXP		 [bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; KN 93 promotes the reaction [Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; Wortmannin inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK3 protein modified form]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [ON123300 results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK3 mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]; Wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; Wortmannin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK3 protein]
Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of MAPK3 protein]
wortmannin results in decreased phosphorylation of MAPK3 protein
wortmannin results in increased phosphorylation of MAPK3 protein
Wortmannin affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]		 CTD PMID:10611455 PMID:15086530 PMID:15177934 PMID:15355987 PMID:15608143 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK6 mRNA] CTD PMID:36190352 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
decreases phosphorylation		 ISO
EXP		 wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK8 protein]; wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK8 protein]
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK8 mRNA]
Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of MAPK8 protein]
wortmannin results in decreased phosphorylation of MAPK8 protein		 CTD PMID:10611455 PMID:18950629 PMID:36190352 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of MAPK9 protein] CTD PMID:10611455 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases phosphorylation		 ISO Melatonin inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]; Vitamin E inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]
Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPT protein]]		 CTD PMID:15842767 PMID:31173752 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression		 ISO AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased stability of and results in decreased ubiquitination of MCL1 protein]; Wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]; Wortmannin promotes the reaction [Doxorubicin results in decreased expression of MCL1 protein]; Wortmannin promotes the reaction [Etoposide results in decreased expression of MCL1 protein]
wortmannin results in decreased expression of MCL1 protein		 CTD PMID:15970427 PMID:17935137 PMID:23353698 PMID:32802178 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO wortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein]; wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein] CTD PMID:17935137 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mir200a microRNA 200a multiple interactions ISO [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA CTD PMID:25969534 NCBI chr 5:166,648,494...166,648,582 JBrowse link
G Mir21 microRNA 21 multiple interactions ISO wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; wortmannin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] CTD PMID:23052036 PMID:25969534 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir22 microRNA 22 multiple interactions ISO [wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA CTD PMID:25969534 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133 		JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] CTD PMID:16359550 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of MMP14 protein] CTD PMID:36288207 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin results in decreased expression of and results in decreased activity of MMP2 protein
wortmannin results in decreased expression of MMP2		 CTD PMID:23707804 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity		 EXP
ISO		 wortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]
wortmannin results in decreased activity of MMP9 protein
wortmannin inhibits the reaction [fucoidan results in decreased expression of MMP9]; wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wortmannin promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein]		 CTD PMID:20195827 PMID:22033475 PMID:23288142 PMID:24333868 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP		 Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]
wortmannin inhibits the reaction [resveratrol results in decreased activity of MPO protein]		 CTD PMID:18987595 PMID:20117814 PMID:26262998 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Ms4a2 membrane spanning 4-domains A2 multiple interactions
decreases response to substance		 ISO MS4A2 protein mutant form inhibits the reaction [wortmannin inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide]]
MS4A2 protein mutant form results in decreased susceptibility to wortmannin		 CTD PMID:19467708 NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Wortmannin inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA] CTD PMID:11551972 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mt3 metallothionein 3 decreases response to substance ISO wortmannin results in decreased susceptibility to MT3 protein CTD PMID:19767621 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of MTOR protein]; Wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein]
Wortmannin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MTOR protein]		 CTD PMID:19139269 PMID:32802178 PMID:36288207 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Wortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MYC mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MYC protein]
Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of MYC protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MYC mRNA]		 CTD PMID:33582643 PMID:36190352 PMID:36288207 PMID:37992829 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor multiple interactions ISO wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein] CTD PMID:12569580 NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590 		JBrowse link
G Myh4 myosin heavy chain 4 multiple interactions ISO Wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA] CTD PMID:19657059 NCBI chr10:51,923,149...51,946,297
Ensembl chr10:51,885,913...51,946,295 		JBrowse link
G Myl7 myosin light chain 7 multiple interactions
decreases phosphorylation		 ISO wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]
wortmannin results in decreased phosphorylation of MYL7 protein		 CTD PMID:15621049 NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions ISO Wortmannin inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein] CTD PMID:32283200 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641 		JBrowse link
G Ncs1 neuronal calcium sensor 1 multiple interactions EXP wortmannin inhibits the reaction [NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate] CTD PMID:12471042 NCBI chr 3:14,523,220...14,568,829
Ensembl chr 3:14,523,220...14,568,829 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases phosphorylation
multiple interactions		 ISO wortmannin results in decreased phosphorylation of NDRG1 protein
wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of NDRG1 protein]		 CTD PMID:20880397 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase multiple interactions EXP wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]] CTD PMID:20100827 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]] CTD PMID:34077701 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:18207479 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Wortmannin inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Etoposide results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein]
wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]]		 CTD PMID:15142122 PMID:17935137 PMID:20005289 PMID:23170834 PMID:24085292 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions
decreases activity		 ISO
EXP		 wortmannin inhibits the reaction [NGF results in increased localization of TRPV1 protein]; wortmannin inhibits the reaction [NGF results in increased susceptibility to Capsaicin]
wortmannin results in decreased activity of NGF protein
wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]; wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]]; wortmannin inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:12815188 PMID:16319926 PMID:17324588 PMID:20629186 PMID:21975456 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Carvedilol promotes the reaction [Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]
wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]		 CTD PMID:12839867 PMID:17159805 PMID:22952890 PMID:24462917 PMID:25352548 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases phosphorylation		 ISO
EXP		 Fenofibrate inhibits the reaction [wortmannin results in decreased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [diallyl disulfide results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [diallyl trisulfide results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; wortmannin inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]]; wortmannin inhibits the reaction [Progesterone results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [Progesterone results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]; wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]]; wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]
wortmannin affects the reaction [Carbon Tetrachloride results in increased phosphorylation of and results in increased activity of NOS3 protein]		 CTD PMID:11788791 PMID:15358673 PMID:16442496 PMID:18296501 PMID:18317400 More... NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO wortmannin inhibits the reaction [Zinc affects the localization of NOTCH1 protein]; wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein] CTD PMID:17513037 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; Wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein] CTD PMID:20028456 PMID:34077701 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions ISO wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein] CTD PMID:19549922 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Ntf3 neurotrophin 3 decreases transport ISO wortmannin results in decreased transport of NTF3 protein CTD PMID:11948662 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Ntf4 neurotrophin 4 decreases transport ISO wortmannin results in decreased transport of NTF4 protein CTD PMID:11948662 NCBI chr 1:95,893,560...95,896,391
Ensembl chr 1:95,893,457...95,897,243 		JBrowse link
G Nts neurotensin multiple interactions ISO wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15177934 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of PA2G4 mRNA] CTD PMID:37992829 NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; Wortmannin promotes the reaction [demethoxycurcumin results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [sodium arsenite results in increased degradation of PARP1 protein]
wortmannin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]		 CTD PMID:12614848 PMID:17935137 PMID:22155090 PMID:32802178 PMID:34291863 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP [troglitazone co-treated with wortmannin] results in decreased expression of PCK1 mRNA CTD PMID:10446394 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Wortmannin results in increased expression of PDCD4 mRNA; Wortmannin results in increased expression of PDCD4 protein CTD PMID:17259349 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO wortmannin inhibits the reaction [Dexamethasone results in increased phosphorylation of PDK1 protein] CTD PMID:21655274 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions ISO wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]
[wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]; wortmannin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]		 CTD PMID:9873045 PMID:11574405 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Pdzk1 PDZ domain containing 1 multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of PDZK1 mRNA] CTD PMID:36190352 PMID:37992829 NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514 		JBrowse link
G Pgr progesterone receptor decreases reaction EXP wortmannin inhibits the reaction [estrogen increases expression of Pgr mRNA] in rat uterus RGD PMID:17272396 RGD:152177689 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions
decreases activity		 ISO wortmannin inhibits the reaction [Sirolimus results in increased activity of PIK3CA protein]
Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of PIK3CA protein]
wortmannin results in decreased activity of PIK3CA protein		 CTD PMID:16227402 PMID:19036708 PMID:36288207 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta decreases activity
multiple interactions		 ISO wortmannin results in decreased activity of PIK3CB protein
Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of PIK3CB protein]		 CTD PMID:11931710 PMID:36288207 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases activity ISO wortmannin results in decreased activity of PIK3CD protein CTD PMID:21644799 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions
decreases activity		 ISO
EXP		 wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]
wortmannin promotes the reaction [GRK2 protein promotes the reaction [GRK2 protein binds to PIK3CG protein]]
wortmannin results in decreased activity of PIK3CG protein		 CTD PMID:15178407 PMID:21644799 PMID:28759639 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases activity
multiple interactions		 ISO
EXP		 wortmannin results in decreased activity of PIK3R1 protein
Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of PIK3R1 mRNA]]		 CTD PMID:19036708 PMID:27832966 PMID:32805344 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Plac1 placenta enriched 1 multiple interactions ISO wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA] CTD PMID:15803460 NCBI chr  X:132,821,347...132,955,143
Ensembl chr  X:132,821,347...132,985,668 		JBrowse link
G Pln phospholamban multiple interactions EXP wortmannin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]] CTD PMID:28324061 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Postn periostin multiple interactions EXP wortmannin inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA] CTD PMID:15121739 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARA mRNA] CTD PMID:23399309 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARD mRNA] CTD PMID:23399309 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARG mRNA] CTD PMID:23399309 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D multiple interactions ISO wortmannin inhibits the reaction [Soil Pollutants results in increased expression of PPM1D protein] CTD PMID:22409540 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] CTD PMID:17209049 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; wortmannin inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein] CTD PMID:11424089 PMID:17171638 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions ISO PRKDC protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene] CTD PMID:20888899 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Prpf19 pre-mRNA processing factor 19 multiple interactions EXP wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]] CTD PMID:20629186 NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO
EXP		 Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin]; Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide]; Wortmannin inhibits the reaction [tetrachlorodian results in decreased expression of PTEN mRNA]
Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of PTEN mRNA]]; Wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]; Wortmannin inhibits the reaction [Zinc Sulfate results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased ubiquitination of PTEN protein]		 CTD PMID:17935137 PMID:20100827 PMID:27832966 PMID:32805344 PMID:36190352 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptger1 prostaglandin E receptor 1 multiple interactions ISO wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein] CTD PMID:20335389 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin]; wortmannin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 protein]
Wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; Wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]		 CTD PMID:15980035 PMID:18089846 PMID:18840457 PMID:22952890 PMID:23968725 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO
EXP		 [Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein; [Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with Tetradecanoylphorbol Acetate] inhibits the reaction [oxotremorine M results in increased phosphorylation of PTK2 protein]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]; oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]; wortmannin inhibits the reaction [Testosterone results in increased phosphorylation of PTK2 protein]
[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein; KNG1 protein inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; wortmannin inhibits the reaction [KNG1 protein results in increased phosphorylation of PTK2 protein]		 CTD PMID:10537051 PMID:16038899 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Pxn paxillin multiple interactions ISO [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]; wortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of PXN protein] CTD PMID:10537051 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Rad23b RAD23 homolog B, nucleotide excision repair protein multiple interactions ISO wortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein] CTD PMID:21742020 NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319 		JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [wortmannin co-treated with docetaxel] results in decreased expression of RAD50 protein CTD PMID:20878124 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO wortmannin promotes the reaction [hydroxyflutamide results in increased phosphorylation of RAF1 protein]; wortmannin promotes the reaction [ON123300 results in increased phosphorylation of RAF1 protein] CTD PMID:24568969 PMID:28163245 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] CTD PMID:16963453 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO
EXP		 wortmannin inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein]; wortmannin inhibits the reaction [Vanadates results in increased phosphorylation of RB1 protein]
Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased phosphorylation of RB1 protein]]; Wortmannin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of RB1 protein]		 CTD PMID:10849422 PMID:14971663 PMID:18353414 PMID:30542433 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO wortmannin inhibits the reaction [Norepinephrine affects the localization of REL protein]; wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]] CTD PMID:23114885 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]; wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]
Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of RELA protein]]		 CTD PMID:17982072 PMID:18207479 PMID:24462917 PMID:32805344 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Riox2 ribosomal oxygenase 2 multiple interactions ISO wortmannin inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA] CTD PMID:24434654 NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein] CTD PMID:20335389 PMID:23001822 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation		 EXP
ISO		 wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]
Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of RPS6KB1 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]
wortmannin results in decreased phosphorylation of RPS6KB1 protein
wortmannin inhibits the reaction [arsenite affects the activity of RPS6KB1 protein]		 CTD PMID:14516795 PMID:20936651 PMID:21195169 PMID:25663935 PMID:32802178 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions ISO wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein] CTD PMID:12087098 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078 		JBrowse link
G Scg2 secretogranin II decreases activity ISO wortmannin results in decreased activity of SCG2 protein alternative form CTD PMID:9473216 NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097 		JBrowse link
G Sct secretin multiple interactions EXP wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; wortmannin inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT] CTD PMID:22194894 NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658 		JBrowse link
G Selenop selenoprotein P increases expression ISO wortmannin results in increased expression of SELENOP protein CTD PMID:24535192 NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] CTD PMID:16458614 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions ISO wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 mRNA]; wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 protein] CTD PMID:13679210 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801 		JBrowse link
G Sftpc surfactant protein C decreases expression ISO wortmannin results in decreased expression of SFTPC protein CTD PMID:15695173 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions ISO wortmannin inhibits the reaction [Dexamethasone results in increased phosphorylation of SGK1 protein] CTD PMID:21655274 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Shbg sex hormone binding globulin multiple interactions EXP wortmannin inhibits the reaction [nonylphenol results in increased expression of SHBG mRNA] CTD PMID:27832966 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Sirpa signal-regulatory protein alpha multiple interactions ISO wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] CTD PMID:12805067 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein]
wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]		 CTD PMID:18298901 PMID:22952890 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 multiple interactions
decreases activity		 EXP wortmannin inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]
wortmannin results in decreased activity of SLC1A1 protein		 CTD PMID:16150575 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP
ISO		 Wortmannin inhibits the reaction [4-hydroxyisoleucine results in increased localization of SLC2A4 protein]; Wortmannin inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]
wortmannin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]		 CTD PMID:11978788 PMID:18591783 PMID:22610671 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions EXP wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein] CTD PMID:15691865 NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO wortmannin inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]] CTD PMID:20300827 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO wortmannin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine] CTD PMID:20875051 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein] CTD PMID:22685291 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP wortmannin results in increased expression of SOD2 mRNA CTD PMID:20596034 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sort1 sortilin 1 multiple interactions
increases ubiquitination		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [wortmannin results in increased degradation of SORT1 protein]; wortmannin inhibits the reaction [INS1 protein results in increased expression of SORT1 protein]; wortmannin results in decreased expression of and results in increased degradation of SORT1 protein
wortmannin results in increased ubiquitination of SORT1 protein		 CTD PMID:25805502 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
decreases reaction		 ISO
EXP		 wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein]
wortmannin inhibits the reaction [estrogen increases expression of Sp1 mRNA] in rat uterus		 CTD
RGD		 PMID:17441964 PMID:17272396 RGD:152177689 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
decreases expression		 ISO [wortmannin co-treated with Ethanol] results in increased expression of SQSTM1 protein
wortmannin results in increased expression of SQSTM1 protein
wortmannin results in decreased expression of SQSTM1 protein		 CTD PMID:22459179 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein] CTD PMID:25856345 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Wortmannin inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Wortmannin inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein] CTD PMID:22031849 PMID:25398788 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srf serum response factor multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of SRF mRNA] CTD PMID:36190352 PMID:37992829 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of STAR mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of STAR mRNA] CTD PMID:25253736 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]; wortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein]; wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]; wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]; wortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 PMID:24055520 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein] CTD PMID:30851366 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of TFF1 mRNA] CTD PMID:36190352 PMID:37992829 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO wortmannin inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein] CTD PMID:21649584 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO
EXP		 wortmannin affects the reaction [HU 211 results in decreased expression of TH mRNA]
[wortmannin co-treated with manganese chloride] results in decreased expression of TH protein		 CTD PMID:18950629 PMID:23604964 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO wortmannin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA] CTD PMID:22841774 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein] CTD PMID:19252288 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance		 ISO
EXP		 Wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; Wortmannin inhibits the reaction [Dieldrin results in increased expression of TNF mRNA]; Wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Wortmannin results in increased susceptibility to TNF protein
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]
Wortmannin inhibits the reaction [4-hydroxyisoleucine inhibits the reaction [TNF protein results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]		 CTD PMID:12805067 PMID:12839867 PMID:16458614 PMID:16968468 PMID:17464197 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases phosphorylation		 ISO
EXP		 Wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [3,3'-diindolylmethane results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Asbestos, Serpentine results in increased expression of TP53 protein]; Wortmannin inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Wortmannin inhibits the reaction [Mustard Gas results in increased expression of TP53 protein]; Wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [spermine nitric oxide complex results in increased phosphorylation of TP53 protein]; Wortmannin promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein]; Wortmannin results in decreased phosphorylation of and results in decreased expression of TP53 protein
wortmannin results in decreased phosphorylation of TP53 protein
wortmannin inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; wortmannin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of TP53 protein]		 CTD PMID:11751435 PMID:12676607 PMID:15489221 PMID:15837074 PMID:16024610 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO wortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein]; wortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein] CTD PMID:21214929 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Tpp2 tripeptidyl peptidase 2 multiple interactions ISO wortmannin promotes the reaction [Etoposide affects the localization of TPP2 protein] CTD PMID:20643100 NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO wortmannin inhibits the reaction [NGF results in increased localization of TRPV1 protein] CTD PMID:16319926 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA] CTD PMID:34077701 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Tyr tyrosinase multiple interactions ISO [Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of TYR protein
[Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein		 CTD PMID:28849034 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Usp7 ubiquitin specific peptidase 7 multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein] CTD PMID:32802178 NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases secretion
decreases reaction		 ISO
EXP		 [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [Oxaliplatin results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of VEGFA mRNA]
Wortmannin results in decreased secretion of VEGFA protein
wortmannin inhibits the reaction [estrogen increases expression of Vegfa mRNA] in rat uterus		 CTD
RGD		 PMID:13679210 PMID:15050414 PMID:16499871 PMID:18252963 PMID:18790786 More... RGD:152177689 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin decreases expression ISO wortmannin results in decreased expression of VIM protein CTD PMID:25856345 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 multiple interactions ISO [wortmannin co-treated with docetaxel] results in decreased expression of XRCC5 protein CTD PMID:20878124 NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions ISO [wortmannin co-treated with docetaxel] results in decreased expression of XRCC6 protein CTD PMID:20878124 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions ISO wortmannin promotes the reaction [Cisplatin results in increased expression of YAP1 protein modified form]; wortmannin promotes the reaction [Doxorubicin results in increased expression of YAP1 protein modified form] CTD PMID:21214929 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta multiple interactions EXP wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]; wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]] CTD PMID:20629186 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105 		JBrowse link
G Zfp143 zinc finger protein 143 multiple interactions ISO wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein] CTD PMID:20733350 NCBI chr 1:164,109,041...164,144,902
Ensembl chr 1:164,109,116...164,144,902 		JBrowse link
PX-866 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO PX-866 results in decreased phosphorylation of AKT1 protein
PX-866 inhibits the reaction [[Calcium co-treated with Ionomycin] results in increased phosphorylation of AKT1 protein]; PX-866 promotes the reaction [STO 609 results in decreased phosphorylation of AKT1 protein]; STO 609 promotes the reaction [PX-866 results in decreased phosphorylation of AKT1 protein]		 CTD PMID:25805502 PMID:28634229 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Axin2 axin 2 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of AXIN2 mRNA CTD PMID:27017931 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions		 ISO PX-866 results in decreased phosphorylation of BAD protein
[PX-866 co-treated with BBR3610] results in decreased phosphorylation of BAD protein		 CTD PMID:20473884 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of BHLHE40 mRNA CTD PMID:27017931 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 affects response to substance ISO CAMKK2 protein affects the susceptibility to PX-866 CTD PMID:28634229 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCND1 mRNA CTD PMID:27017931 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne2 cyclin E2 decreases expression
multiple interactions		 ISO PX-866 results in decreased expression of CCNE2 mRNA
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCNE2 mRNA		 CTD PMID:26660119 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA CTD PMID:25805502 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdc6 cell division cycle 6 multiple interactions
decreases expression		 ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CDC6 mRNA
PX-866 results in decreased expression of CDC6 mRNA		 CTD PMID:26660119 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of CDKN1A mRNA CTD PMID:27017931 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA CTD PMID:25805502 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of E2F1 mRNA CTD PMID:26660119 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA] CTD PMID:25805502 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of HBEGF mRNA CTD PMID:27017931 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Il11 interleukin 11 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of IL11 mRNA CTD PMID:26660119 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of LIF mRNA CTD PMID:27017931 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases phosphorylation
multiple interactions		 ISO PX-866 results in decreased phosphorylation of MDM2 protein
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of MDM2 protein		 CTD PMID:27017931 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA] CTD PMID:25805502 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of RB1 protein CTD PMID:26660119 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA] CTD PMID:25805502 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sort1 sortilin 1 multiple interactions
decreases expression		 ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA; [PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA; PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA]; SORT1 protein inhibits the reaction [PX-866 results in increased abundance of Triglycerides]
PX-866 results in decreased expression of SORT1 protein		 CTD PMID:25805502 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of TERT mRNA CTD PMID:27017931 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        inhibitor 18924
          autophagy inhibitor 861
            wortmannin 296
              PX-866 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      monocarboxylic acid 18004
                                        acetic acid 11085
                                          acetate ester 4056
                                            wortmannin 296
                                              PX-866 22
paths to the root