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G |
Acadsb |
acyl-CoA dehydrogenase, short/branched chain |
decreases expression |
ISO |
indirubin results in decreased expression of ACADSB mRNA |
CTD |
PMID:15056799 |
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NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects binding increases activity |
ISO EXP |
indirubin binds to and results in increased activity of AHR protein indirubin binds to AHR protein AHR mutant form inhibits the reaction [indirubin results in increased expression of CYP1A1 protein]; AHR mutant form inhibits the reaction [indirubin results in increased expression of CYP1B1 protein]; indirubin binds to and results in increased activity of AHR protein; indirubin promotes the reaction [AHR protein binds to ARNT protein]; indirubin promotes the reaction [AHR protein binds to CYP1A1 promoter]; indirubin results in increased localization of and results in increased degradation of AHR protein indirubin results in increased activity of AHR protein |
CTD |
PMID:11425848 PMID:12972062 PMID:15001395 PMID:15056799 PMID:19299563 PMID:19860415 PMID:20634293 PMID:20951181 PMID:25329374 More...
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aqp9 |
aquaporin 9 |
multiple interactions |
ISO |
[[tetraarsenic tetrasulfide co-treated with indirubin] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [[tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein; indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein] |
CTD |
PMID:18344322 |
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NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G |
Arf4 |
ARF GTPase 4 |
decreases expression |
ISO |
indirubin results in decreased expression of ARF4 mRNA |
CTD |
PMID:15056799 |
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NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions increases activity |
EXP ISO |
indirubin promotes the reaction [AHR protein binds to ARNT protein] indirubin results in increased activity of ARNT protein |
CTD |
PMID:12972062 PMID:20951181 |
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NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[arsenic disulfide co-treated with indirubin] results in increased expression of and results in increased cleavage of BAX protein; [arsenic disulfide co-treated with indirubin] results in increased expression of BAX mRNA |
CTD |
PMID:25789073 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[arsenic disulfide co-treated with indirubin] results in decreased expression of BCL2 mRNA |
CTD |
PMID:25789073 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[arsenic disulfide co-treated with indirubin] results in increased expression of CASP3 mRNA |
CTD |
PMID:25789073 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccn1 |
cellular communication network factor 1 |
increases expression |
ISO |
indirubin results in increased expression of CCN1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G |
Cct4 |
chaperonin containing TCP1 subunit 4 |
decreases expression |
ISO |
indirubin results in decreased expression of CCT4 mRNA |
CTD |
PMID:15056799 |
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NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267
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G |
Cd40lg |
CD40 ligand |
multiple interactions |
ISO |
indirubin inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of IGHE mRNA]; indirubin inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of IGHG2 mRNA]; indirubin inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of IGHG3 mRNA]; indirubin inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of IGHG4 mRNA] |
CTD |
PMID:38526216 |
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NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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G |
Cdh2 |
cadherin 2 |
decreases expression |
ISO |
indirubin results in decreased expression of CDH2 mRNA |
CTD |
PMID:15056799 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
indirubin results in decreased expression of CDK1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression multiple interactions decreases activity |
ISO |
indirubin results in decreased expression of CDK2 protein indirubin inhibits the reaction [CDK2 protein results in increased phosphorylation of RB1 protein] indirubin results in decreased activity of CDK2 protein [tanshinone co-treated with indirubin] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of CDK2 protein]; [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased expression of CDK2 protein] |
CTD |
PMID:16115123 PMID:18344322 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression multiple interactions |
ISO |
indirubin results in increased expression of CDKN1B protein indirubin promotes the reaction [tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]; indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]; tanshinone promotes the reaction [indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; tetraarsenic tetrasulfide promotes the reaction [indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]] |
CTD |
PMID:18344322 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPA protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPA protein] |
CTD |
PMID:18344322 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPB protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPB protein] |
CTD |
PMID:18344322 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Cebpe |
CCAAT/enhancer binding protein epsilon |
multiple interactions |
ISO |
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPE protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPE protein] |
CTD |
PMID:18344322 |
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NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814
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G |
Clk1 |
CDC-like kinase 1 |
decreases expression |
ISO |
indirubin results in decreased expression of CLK1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
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G |
Cops2 |
COP9 signalosome subunit 2 |
decreases expression |
ISO |
indirubin results in decreased expression of COPS2 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 3:113,084,174...113,110,090
Ensembl chr 3:113,084,176...113,109,947
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G |
Csf3r |
colony stimulating factor 3 receptor |
increases expression |
ISO |
indirubin results in increased expression of CSF3R protein |
CTD |
PMID:16115123 |
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NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881
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G |
Cxcr1 |
C-X-C motif chemokine receptor 1 |
increases expression |
ISO |
indirubin results in increased expression of CXCR1 protein |
CTD |
PMID:16115123 |
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NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases expression |
ISO |
indirubin results in increased expression of CYP19A1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression increases activity increases metabolic processing |
EXP ISO |
AHR mutant form inhibits the reaction [indirubin results in increased expression of CYP1A1 protein]; indirubin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; indirubin promotes the reaction [AHR protein binds to CYP1A1 promoter] indirubin results in increased expression of CYP1A1 mRNA; indirubin results in increased expression of CYP1A1 protein indirubin binds to and results in decreased activity of CYP1A1 protein; indirubin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] indirubin results in increased activity of CYP1A1 protein CYP1A1 protein results in increased metabolism of indirubin |
CTD |
PMID:14637189 PMID:15001395 PMID:15056799 PMID:18493746 PMID:19299563 PMID:20951181 More...
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
ISO |
indirubin results in increased expression of CYP1A2 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing increases expression multiple interactions |
ISO EXP |
CYP1B1 protein results in increased metabolism of indirubin indirubin results in increased expression of CYP1B1 mRNA indirubin results in increased expression of CYP1B1 mRNA; indirubin results in increased expression of CYP1B1 protein AHR mutant form inhibits the reaction [indirubin results in increased expression of CYP1B1 protein] |
CTD |
PMID:14637189 PMID:20951181 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression |
ISO |
indirubin results in decreased expression of E2F1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
ISO |
indirubin results in increased expression of GSTP1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
H1f2 |
H1.2 linker histone, cluster member |
decreases phosphorylation multiple interactions |
ISO |
indirubin results in decreased phosphorylation of H1F2 protein [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein]; tanshinone promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein]; tetraarsenic tetrasulfide promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein] |
CTD |
PMID:18344322 |
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NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
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G |
Hdac1 |
histone deacetylase 1 |
multiple interactions |
ISO |
[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]] |
CTD |
PMID:18344322 |
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NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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G |
Hsbp1 |
heat shock factor binding protein 1 |
decreases expression |
ISO |
indirubin results in decreased expression of HSBP1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr19:47,401,039...47,405,373
Ensembl chr19:47,400,966...47,435,821
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
decreases expression |
ISO |
indirubin results in decreased expression of HSPD1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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G |
Hsph1 |
heat shock protein family H (Hsp110) member 1 |
decreases expression |
ISO |
indirubin results in decreased expression of HSPH1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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G |
Ifng |
interferon gamma |
decreases expression |
ISO |
indirubin results in decreased expression of IFNG protein |
CTD |
PMID:11134660 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
ISO |
indirubin results in increased expression of IGFBP1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
IgG-2a |
gamma-2a immunoglobulin heavy chain |
multiple interactions |
ISO |
indirubin inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of IGHG4 mRNA] |
CTD |
PMID:38526216 |
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G |
Ighe |
immunoglobulin heavy constant epsilon |
multiple interactions |
ISO |
indirubin inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of IGHE mRNA] |
CTD |
PMID:38526216 |
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G |
Il1r1 |
interleukin 1 receptor type 1 |
decreases expression |
ISO |
indirubin results in decreased expression of IL1R1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
indirubin inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of IGHE mRNA]; indirubin inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of IGHG2 mRNA]; indirubin inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of IGHG3 mRNA]; indirubin inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of IGHG4 mRNA] |
CTD |
PMID:38526216 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
decreases expression |
ISO |
indirubin results in decreased expression of IL6 protein |
CTD |
PMID:11134660 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ilf2 |
interleukin enhancer binding factor 2 |
decreases expression |
ISO |
indirubin results in decreased expression of ILF2 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 2:175,952,174...175,971,191
Ensembl chr 2:175,952,186...175,971,337
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G |
Itgb1 |
integrin subunit beta 1 |
decreases expression |
ISO |
indirubin results in decreased expression of ITGB1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgb2 |
integrin subunit beta 2 |
increases expression |
ISO |
indirubin results in increased expression of ITGB2 protein |
CTD |
PMID:16115123 |
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NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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G |
Jup |
junction plakoglobin |
increases expression |
EXP |
indirubin results in increased expression of JUP mRNA |
CTD |
PMID:20951181 |
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NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057
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G |
Mgst2 |
microsomal glutathione S-transferase 2 |
decreases expression |
ISO |
indirubin results in decreased expression of MGST2 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
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G |
Msh2 |
mutS homolog 2 |
decreases expression |
ISO |
indirubin results in decreased expression of MSH2 mRNA |
CTD |
PMID:15056799 |
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NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC mRNA]; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC protein] |
CTD |
PMID:18344322 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
increases expression |
ISO |
indirubin results in increased expression of NCF1 protein |
CTD |
PMID:16115123 |
|
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression |
EXP |
indirubin results in increased expression of NFE2L2 mRNA |
CTD |
PMID:20951181 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Npc1 |
NPC intracellular cholesterol transporter 1 |
increases expression |
ISO |
indirubin results in increased expression of NPC1 mRNA |
CTD |
PMID:15056799 |
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NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
EXP |
indirubin results in increased expression of NQO1 mRNA |
CTD |
PMID:20951181 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Pram1 |
PML-RARA regulated adaptor molecule 1 |
multiple interactions |
ISO |
[tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 protein |
CTD |
PMID:18344322 |
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NCBI chr 7:14,428,548...14,438,081
Ensembl chr 7:14,420,165...14,438,166
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G |
Rarb |
retinoic acid receptor, beta |
multiple interactions |
ISO |
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of RARB mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of RARB mRNA]; [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]] |
CTD |
PMID:18344322 |
|
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
indirubin inhibits the reaction [CDK2 protein results in increased phosphorylation of RB1 protein] [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein; [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased phosphorylation of RB1 protein; [tanshinone co-treated with indirubin] results in increased expression of RB1 protein |
CTD |
PMID:16115123 PMID:18344322 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Septin2 |
septin 2 |
decreases expression |
ISO |
indirubin results in decreased expression of SEPTIN2 mRNA |
CTD |
PMID:15056799 |
|
NCBI chr 9:94,018,141...94,051,386
Ensembl chr 9:94,018,208...94,051,386
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G |
Slc2a2 |
solute carrier family 2 member 2 |
decreases expression |
ISO |
indirubin results in decreased expression of SLC2A2 mRNA |
CTD |
PMID:15056799 |
|
NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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G |
Spi1 |
Spi-1 proto-oncogene |
increases activity |
ISO |
indirubin results in increased activity of SPI1 protein |
CTD |
PMID:16115123 |
|
NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
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G |
Tcf12 |
transcription factor 12 |
decreases expression |
ISO |
indirubin results in decreased expression of TCF12 mRNA |
CTD |
PMID:15056799 |
|
NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201
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G |
Top1 |
DNA topoisomerase I |
decreases expression |
ISO |
indirubin results in decreased expression of TOP1 mRNA |
CTD |
PMID:15056799 |
|
NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
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G |
Top2a |
DNA topoisomerase II alpha |
decreases expression |
ISO |
indirubin results in decreased expression of TOP2A mRNA |
CTD |
PMID:15056799 |
|
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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G |
Actb |
actin, beta |
affects expression |
ISO |
indirubin-3'-monoxime affects the expression of ACTB protein |
CTD |
PMID:18958680 |
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NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects binding |
ISO |
AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of CD86 protein]; AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of ITGAX protein] indirubin-3'-monoxime binds to AHR protein indirubin-3'-monoxime binds to and results in increased activity of AHR protein |
CTD |
PMID:15001395 PMID:21948866 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
multiple interactions increases expression |
ISO |
Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of ALDH1A1 protein] |
CTD |
PMID:21948866 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldh1a2 |
aldehyde dehydrogenase 1 family, member A2 |
decreases expression |
ISO |
indirubin-3'-monoxime results in decreased expression of ALDH1A2 protein |
CTD |
PMID:21948866 |
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NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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G |
Aqp9 |
aquaporin 9 |
multiple interactions |
ISO |
indirubin-3'-monoxime promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; indirubin-3'-monoxime promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein] |
CTD |
PMID:18344322 |
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NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G |
Ar |
androgen receptor |
increases activity |
ISO |
indirubin-3'-monoxime analog results in increased activity of AR protein; indirubin-3'-monoxime results in increased activity of AR protein |
CTD |
PMID:21111724 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bax |
BCL2 associated X, apoptosis regulator |
decreases expression |
ISO |
indirubin-3'-monoxime results in decreased expression of BAX mRNA |
CTD |
PMID:18958680 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BCL2L1 mRNA |
CTD |
PMID:18958680 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CASP8 mRNA |
CTD |
PMID:18958680 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Cat |
catalase |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CAT mRNA |
CTD |
PMID:18958680 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl4 |
C-C motif chemokine ligand 4 |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL4 mRNA |
CTD |
PMID:18958680 |
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NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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G |
Cd40 |
CD40 molecule |
multiple interactions decreases expression |
ISO |
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD40 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein] indirubin-3'-monoxime results in decreased expression of CD40 protein |
CTD |
PMID:21948866 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd80 |
Cd80 molecule |
increases expression multiple interactions |
ISO |
indirubin-3'-monoxime results in increased expression of CD80 protein [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased expression of CD80 protein; indirubin-3'-monoxime promotes the reaction [Lipopolysaccharides results in increased expression of CD80 protein] |
CTD |
PMID:21948866 |
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NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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G |
Cd86 |
CD86 molecule |
multiple interactions decreases expression |
ISO |
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD86 protein; AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of CD86 protein]; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein] |
CTD |
PMID:21948866 |
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NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases activity |
ISO |
indirubin-3'-monoxime results in decreased activity of CDK2 protein |
CTD |
PMID:12534346 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CDKN1A mRNA |
CTD |
PMID:18958680 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO EXP |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CYP1A1 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP1A1 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP1A1 protein indirubin-3'-monoxime results in increased expression of CYP1A1 mRNA indirubin-3'-monoxime results in increased expression of CYP1A1 protein |
CTD |
PMID:15001395 PMID:18958680 PMID:21948866 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Ephx2 |
epoxide hydrolase 2 |
decreases expression |
ISO |
indirubin-3'-monoxime results in decreased expression of EPHX2 mRNA |
CTD |
PMID:18958680 |
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NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases expression |
ISO |
indirubin-3'-monoxime results in decreased expression of GPX1 mRNA |
CTD |
PMID:18958680 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases activity |
ISO |
indirubin-3'-monoxime results in decreased activity of GSK3B protein |
CTD |
PMID:12534346 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
increases expression |
ISO |
indirubin-3'-monoxime results in increased expression of GSR mRNA |
CTD |
PMID:18958680 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HMOX1 mRNA |
CTD |
PMID:18958680 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa2 |
heat shock protein family A (Hsp70) member 2 |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in decreased expression of HSPA2 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA2 mRNA |
CTD |
PMID:18958680 |
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NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
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G |
Hspa6l-ps1 |
heat shock protein family A (Hsp70) member 6 like, pseudogene 1 |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA6 mRNA |
CTD |
PMID:18958680 |
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NCBI chr13:83,273,176...83,274,317
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
multiple interactions increases expression |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA9 mRNA indirubin-3'-monoxime results in increased expression of HSPA9 mRNA |
CTD |
PMID:18958680 |
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NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions decreases expression |
ISO |
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of ICAM1 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein] indirubin-3'-monoxime results in decreased expression of ICAM1 protein |
CTD |
PMID:21948866 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ido1 |
indoleamine 2,3-dioxygenase 1 |
increases expression multiple interactions |
ISO |
indirubin-3'-monoxime results in increased expression of IDO1 protein Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of IDO1 protein] |
CTD |
PMID:21948866 |
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NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
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G |
Ido2 |
indoleamine 2,3-dioxygenase 2 |
increases expression multiple interactions |
ISO |
indirubin-3'-monoxime results in increased expression of IDO2 protein Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of IDO2 protein] |
CTD |
PMID:21948866 |
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NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
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G |
Ifng |
interferon gamma |
decreases secretion |
ISO |
indirubin-3'-monoxime results in decreased secretion of IFNG protein |
CTD |
PMID:21948866 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il10 |
interleukin 10 |
multiple interactions decreases secretion |
ISO |
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased secretion of IL10 protein; indirubin-3'-monoxime promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] indirubin-3'-monoxime results in decreased secretion of IL10 protein |
CTD |
PMID:21948866 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of IL1B protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:21948866 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
increases secretion |
ISO |
indirubin-3'-monoxime results in increased secretion of IL2 protein |
CTD |
PMID:21948866 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il27 |
interleukin 27 |
decreases expression multiple interactions |
ISO |
indirubin-3'-monoxime results in decreased expression of IL27 protein Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of IL27 protein] |
CTD |
PMID:21948866 |
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NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of IL6 protein; [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of IL6 protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:21948866 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgax |
integrin subunit alpha X |
multiple interactions decreases expression |
ISO |
AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of ITGAX protein]; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAX protein] |
CTD |
PMID:21948866 |
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NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
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G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
increases expression |
ISO |
indirubin-3'-monoxime analog results in increased expression of KLK3 mRNA; indirubin-3'-monoxime results in increased expression of KLK3 mRNA |
CTD |
PMID:21111724 |
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NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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G |
Lck |
LCK proto-oncogene, Src family tyrosine kinase |
decreases activity |
ISO |
indirubin-3'-monoxime results in decreased activity of LCK protein |
CTD |
PMID:12534346 |
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NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
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G |
Mt2A |
metallothionein 2A |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MT2A mRNA |
CTD |
PMID:18958680 |
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NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in decreased expression of NFKBIA mRNA |
CTD |
PMID:18958680 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein |
CTD |
PMID:18958680 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rad23a |
RAD23 homolog A, nucleotide excision repair protein |
decreases expression |
ISO |
indirubin-3'-monoxime results in decreased expression of RAD23A mRNA |
CTD |
PMID:18958680 |
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NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases activity |
ISO |
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased activity of RELA protein indirubin-3'-monoxime results in decreased activity of RELA protein |
CTD |
PMID:21948866 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SERPINE1 mRNA |
CTD |
PMID:18958680 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
decreases activity |
ISO |
indirubin-3'-monoxime results in decreased activity of SGK1 protein |
CTD |
PMID:12534346 |
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NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SOD2 mRNA |
CTD |
PMID:18958680 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Tgfb2 |
transforming growth factor, beta 2 |
increases expression multiple interactions |
ISO |
indirubin-3'-monoxime results in increased expression of TGFB2 protein Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB2 protein] |
CTD |
PMID:21948866 |
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NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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G |
Tgfb3 |
transforming growth factor, beta 3 |
increases expression multiple interactions |
ISO |
indirubin-3'-monoxime results in increased expression of TGFB3 protein Lipopolysaccharides affects the susceptibility to [indirubin-3'-monoxime results in increased expression of TGFB3 protein] |
CTD |
PMID:21948866 |
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NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased secretion of TNF protein; indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:21948866 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ung |
uracil-DNA glycosylase |
increases expression |
ISO |
indirubin-3'-monoxime results in increased expression of UNG mRNA |
CTD |
PMID:18958680 |
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NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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