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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ABCA1 mRNA] |
CTD |
PMID:12010990 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions affects localization |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone affects the localization of AIFM1 protein] |
CTD |
PMID:19679660 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:17136479 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
decreases activity |
EXP |
Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of ALDH2 protein |
CTD |
PMID:11142365 |
|
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]] |
CTD |
PMID:10567916 |
|
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [bisphenol A results in decreased expression of APOA1 mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of APOE mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of CETP mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of APOE protein]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of CETP protein] |
CTD |
PMID:22056562 PMID:31842455 |
|
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apoe |
apolipoprotein E |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of APOE mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of APOE protein] |
CTD |
PMID:22056562 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases cleavage multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of BCL2 protein Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of BCL2 protein] |
CTD |
PMID:19679660 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC2 protein Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC2 protein] |
CTD |
PMID:19679660 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC3 protein] |
CTD |
PMID:19679660 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP3 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein] |
CTD |
PMID:12821135 PMID:19679660 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP7 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP7 protein] |
CTD |
PMID:12821135 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:19679660 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases expression |
ISO EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CCL2 mRNA] Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of CCL2 mRNA Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] |
CTD |
PMID:12016129 PMID:12846738 PMID:15139008 PMID:16600694 PMID:18706406 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CDKN1A protein |
CTD |
PMID:12821135 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA] |
CTD |
PMID:17952619 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein] |
CTD |
PMID:17030184 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsd |
cathepsin D |
increases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CTSD protein |
CTD |
PMID:10772776 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA |
CTD |
PMID:22851183 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLM mRNA |
CTD |
PMID:22851183 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Hax1 |
HCLS1 associated protein X-1 |
multiple interactions decreases response to substance decreases expression |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein] HAX1 results in decreased susceptibility to Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 mRNA; Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein |
CTD |
PMID:19679660 |
|
NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 protein] |
CTD |
PMID:15588712 PMID:15965080 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of ICAM1 mRNA |
CTD |
PMID:11735124 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ikbkg |
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]] |
CTD |
PMID:17136479 |
|
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of IL6 mRNA] |
CTD |
PMID:12016129 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] |
CTD |
PMID:7476933 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of PDPK1 protein] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA] |
CTD |
PMID:12010990 PMID:17136479 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of IL6 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased expression of IL6 mRNA] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]] |
CTD |
PMID:10616907 PMID:10814840 PMID:12016129 PMID:15601679 PMID:17952619 PMID:18706406 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein] |
CTD |
PMID:10739673 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases activity |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of MMP9 protein |
CTD |
PMID:22033475 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects response to substance |
ISO |
NFE2L2 protein affects the susceptibility to Tosylphenylalanyl Chloromethyl Ketone |
CTD |
PMID:22851183 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased localization of [RELA protein co-treated with NFKB1 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of NFKB1 protein] |
CTD |
PMID:10416616 PMID:10616907 PMID:11094054 PMID:12016129 PMID:16631160 PMID:17952619 More...
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|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases degradation decreases phosphorylation |
ISO EXP |
[Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein] Tosylphenylalanyl Chloromethyl Ketone results in decreased degradation of NFKBIA protein Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIA protein Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein] |
CTD |
PMID:9580637 PMID:10381628 PMID:10921504 PMID:12574206 PMID:15687330 PMID:16288038 PMID:17952619 PMID:18449507 PMID:18666753 More...
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions decreases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein]; Cysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein] |
CTD |
PMID:10381628 |
|
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] |
CTD |
PMID:15601679 PMID:18449507 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased expression of NQO1 mRNA |
CTD |
PMID:22851183 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nrg1 |
neuregulin 1 |
multiple interactions |
EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [NRG1 protein results in increased transport of Glucose] |
CTD |
PMID:14711829 |
|
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of PARP1 protein] |
CTD |
PMID:19679660 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pde5a |
phosphodiesterase 5A |
decreases expression |
EXP |
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of PDE5A mRNA |
CTD |
PMID:12466227 |
|
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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G |
Pdpk1 |
3-phosphoinositide dependent protein kinase-1 |
multiple interactions decreases activity |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of PDPK1 protein] Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of PDPK1 protein |
CTD |
PMID:17136479 |
|
NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
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G |
Plau |
plasminogen activator, urokinase |
decreases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of PLAU protein |
CTD |
PMID:10467400 |
|
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] |
CTD |
PMID:9580637 PMID:17944529 PMID:18449507 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects activity decreases activity |
ISO EXP |
[Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased transport of RELA protein] Tosylphenylalanyl Chloromethyl Ketone affects the activity of RELA protein Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased localization of [RELA protein co-treated with NFKB1 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of RELA protein] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:10416616 PMID:10467400 PMID:10616907 PMID:10640779 PMID:11094054 PMID:12016129 PMID:15687330 PMID:16288038 PMID:16631160 PMID:17136479 PMID:17952619 PMID:18706406 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Scarb1 |
scavenger receptor class B, member 1 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 mRNA] |
CTD |
PMID:12010990 |
|
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 protein] |
CTD |
PMID:7476933 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein] |
CTD |
PMID:10616907 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Sts |
steroid sulfatase |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tretinoin results in increased activity of STS protein] |
CTD |
PMID:16178010 |
|
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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G |
Tcf4 |
transcription factor 4 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]] |
CTD |
PMID:17030184 |
|
NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
[Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:16288038 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased transport of RELA protein] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of RELA protein] |
CTD |
PMID:7476933 PMID:9580637 PMID:10416616 PMID:10616907 PMID:10640779 PMID:12574206 PMID:15601679 PMID:15687330 PMID:18706406 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases response to substance decreases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of and results in increased activity of TP53 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein]; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP7 protein] TP53 protein results in increased susceptibility to Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of TRP53 protein |
CTD |
PMID:11536013 PMID:12821135 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
decreases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of VCAM1 mRNA |
CTD |
PMID:11735124 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of XIAP protein] |
CTD |
PMID:19679660 |
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NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[Sulfur co-treated with zoxamide co-treated with cyflufenamid] results in decreased expression of BAX mRNA; [Sulfur co-treated with zoxamide co-treated with metrafenone] results in decreased expression of BAX mRNA |
CTD |
PMID:35564597 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[Sulfur co-treated with zoxamide co-treated with metrafenone] results in decreased expression of BCL2 mRNA |
CTD |
PMID:35564597 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Dio1 |
iodothyronine deiodinase 1 |
decreases activity |
ISO |
zoxamide results in decreased activity of DIO1 protein |
CTD |
PMID:29228274 PMID:30561685 |
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NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Dio2 |
iodothyronine deiodinase 2 |
decreases activity |
ISO |
zoxamide results in decreased activity of DIO2 protein |
CTD |
PMID:30561685 |
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NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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G |
Dio3 |
iodothyronine deiodinase 3 |
decreases activity |
ISO |
zoxamide results in decreased activity of DIO3 protein |
CTD |
PMID:30561685 |
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NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
[Sulfur co-treated with zoxamide co-treated with metrafenone] results in decreased expression of NFE2L2 mRNA |
CTD |
PMID:35564597 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Tp53 |
tumor protein p53 |
affects activity |
ISO |
zoxamide affects the activity of TP53 protein |
CTD |
PMID:35435491 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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