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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:friedelin
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Accession:CHEBI:5171 term browser browse the term
Definition:A pentacyclic triterpenoid that is perhydropicene which is substituted by an oxo group at position 3 and by methyl groups at the 4, 4a, 6b, 8a, 11, 11, 12b, and 14a-positions (the 4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS-enantiomer). It is the major triterpenoid constituent of cork.
Synonyms:exact_synonym: (4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-octamethylicosahydropicen-3(2H)-one
 related_synonym: D:A-friedooleanan-3-one;   Formula=C30H50O;   InChI=1S/C30H50O/c1-20-21(31)9-10-22-27(20,5)12-11-23-28(22,6)16-18-30(8)24-19-25(2,3)13-14-26(24,4)15-17-29(23,30)7/h20,22-24H,9-19H2,1-8H3/t20-,22+,23-,24+,26+,27+,28-,29+,30-/m0/s1;   InChIKey=OFMXGFHWLZPCFL-SVRPQWSVSA-N;   SMILES=[H][C@@]12CCC(=O)[C@H](C)[C@@]1(C)CC[C@@]1([H])[C@@]2(C)CC[C@@]2(C)[C@]3([H])CC(C)(C)CC[C@]3(C)CC[C@]12C;   friedelan-3-one;   friedeline
 xref: CAS:559-74-0;   KEGG:C08626;   KNApSAcK:C00003747
 xref_mesh: MESH:C060796
 xref: MetaCyc:CPD-13047;   PMID:17639555;   PMID:20610397;   PMID:20675291;   PMID:21718291;   Patent:WO2009072916


show annotations for term's descendants           Sort by:
friedelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO friedelin inhibits the reaction [Ethanol results in increased expression of CASP3 protein] CTD PMID:37939858 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO friedelin inhibits the reaction [Ethanol results in increased expression of PARP1 protein] CTD PMID:37939858 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO friedelin inhibits the reaction [Ethanol results in increased expression of RELA protein] CTD PMID:37939858 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        anti-inflammatory agent 16672
          anti-inflammatory drug 14964
            friedelin 3
              1beta-hydroxyfriedelin 0
              3beta-hydroxyfriedelan-23-oic acid 0
              acetyl aleuritolic acid 0
              friedelin-3,4-lactone 0
              maytenfolone A 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbonyl compound 18914
                                    ketone 17263
                                      cyclic ketone 15911
                                        alicyclic ketone 1268
                                          cyclic terpene ketone 189
                                            friedelin 3
                                              1beta-hydroxyfriedelin 0
                                              3beta-hydroxyfriedelan-23-oic acid 0
                                              acetyl aleuritolic acid 0
                                              friedelin-3,4-lactone 0
                                              maytenfolone A 0
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