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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fraxetin
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Accession:CHEBI:5169 term browser browse the term
Definition:A hydroxycoumarin that is 6-methoxycoumarin in which the hydrogens at positions 7 and 8 have been replaced by hydroxy groups.
Synonyms:exact_synonym: 7,8-dihydroxy-6-methoxy-2H-chromen-2-one
 related_synonym: 7,8-dihydroxy-6-methoxy-2-benzopyrone;   7,8-dihydroxy-6-methoxycoumarin;   Formula=C10H8O5;   InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3;   InChIKey=HAVWRBANWNTOJX-UHFFFAOYSA-N;   SMILES=C12=C(C=C(OC)C(=C1O)O)C=CC(O2)=O
 xref: CAS:574-84-5;   KEGG:C09265;   KNApSAcK:C00002473;   LINCS:LSM-3712
 xref_mesh: MESH:C105671
 xref: PMID:11456117;   PMID:12860476;   PMID:15120578;   PMID:15904944;   PMID:15996779;   PMID:16394523;   PMID:19721227;   PMID:23788190;   PMID:23806420;   PMID:23994349;   PMID:24025985;   PMID:25189268;   PMID:25445053;   PMID:26945887;   PMID:27722139;   PMID:28976788;   PMID:29157824;   PMID:29344176;   PMID:29414667;   PMID:29559590;   PMID:29581584;   PMID:29786751;   PMID:30205426;   PMID:9120770;   Reaxys:198796;   Wikipedia:Fraxetin


show annotations for term's descendants           Sort by:
fraxetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation 		ISO fraxetin inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]
fraxetin results in decreased phosphorylation of AKT1 protein 		CTD PMID:34553399 PMID:37867445 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression 		ISO fraxetin results in decreased expression of BAX protein
Fraxetin increases expression of BAX protein in colorectum
fraxetin results in increased expression of BAX mRNA; fraxetin results in increased expression of BAX protein 		CTD
RGD		 PMID:15996779 PMID:37867445 PMID:32504672 RGD:125097526 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Fraxetin decreases expression of BCL2 protein in colorectum
fraxetin results in decreased expression of BCL2 mRNA; fraxetin results in decreased expression of BCL2 protein 		CTD
RGD		 PMID:37867445 PMID:32504672 RGD:125097526 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 decreases activity
increases cleavage 		ISO fraxetin results in decreased activity of CASP3 protein
fraxetin results in increased cleavage of CASP3 protein 		CTD PMID:15996779 PMID:37867445 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 decreases activity ISO fraxetin results in decreased activity of CASP9 protein CTD PMID:15996779 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions ISO fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of CAT protein] CTD PMID:15904944 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Fraxetin decreases expression of CCNA2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Fraxetin decreases expression of CCNE1 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Fraxetin decreases expression of CDK2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO fraxetin affects the localization of CYCS protein CTD PMID:15996779 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA] CTD PMID:30496664 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO Fraxetin decreases phosphorylation of JAK2 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO fraxetin results in decreased phosphorylation of MAPK8 protein CTD PMID:37867445 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO fraxetin results in decreased expression of MKI67 protein CTD PMID:37867445 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO fraxetin results in increased cleavage of PARP1 protein CTD PMID:37867445 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO Fraxetin decreases expression of SKP2 mRNA and protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO fraxetin inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein] CTD PMID:15904944 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Fraxetin decreases phosphorylation of STAT3 protein in colorectum RGD PMID:32504672 RGD:125097526 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fraxetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA] CTD PMID:30496664 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        antioxidant 16464
          fraxetin 19
            fraxin 0
            sideretin (reduced form) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  oxacycle 18300
                                    benzopyran 12186
                                      1-benzopyran 11917
                                        chromenes 4455
                                          chromenone 4396
                                            coumarins 4159
                                              hydroxycoumarin 361
                                                fraxetin 19
                                                  fraxin 0
                                                  sideretin (reduced form) + 0
paths to the root