Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bosentan
go back to main search page
Accession:CHEBI:51450 term browser browse the term
Definition:A pyrimidine that has formula C27H29N5O6S.
Synonyms:exact_synonym: 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
 related_synonym: 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide;   Formula=C27H29N5O6S;   InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32);   InChIKey=GJPICJJJRGTNOD-UHFFFAOYSA-N;   SMILES=COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1;   bosentanum;   p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
 xref: CAS:147536-97-8;   DrugBank:DB00559;   Drug_Central:392;   KEGG:D07538;   LINCS:LSM-5825
 xref_mesh: MESH:C086232
 xref: Patent:US2986573;   Wikipedia:Bosentan


show annotations for term's descendants           Sort by:
bosentan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
decreases expression		 EXP
ISO		 bosentan metabolite results in decreased activity of ABCB11 protein; bosentan results in decreased activity of ABCB11 protein
bosentan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
bosentan results in decreased expression of ABCB11 mRNA
Bosentan results in decreased expression of ABCB11 mRNA		 CTD PMID:11309550 PMID:15465654 PMID:15509663 PMID:20829430 PMID:23956101 More... NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO bosentan results in decreased expression of ABCB1 mRNA CTD PMID:28369585 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO Bosentan results in decreased expression of ABCB4 mRNA CTD PMID:29761207 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
decreases expression		 EXP
ISO		 bosentan results in increased expression of ABCC2 mRNA
bosentan results in decreased expression of ABCC2 mRNA
Bosentan results in increased expression of ABCC2 mRNA		 CTD PMID:27765674 PMID:28369585 PMID:29761207 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression		 EXP
ISO		 bosentan results in increased expression of ABCC3 mRNA
bosentan results in decreased expression of ABCC3 mRNA		 CTD PMID:27765674 PMID:28369585 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression EXP bosentan results in increased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression
affects expression		 EXP
ISO		 bosentan results in increased expression of ABCG5 mRNA
Bosentan affects the expression of ABCG5 mRNA		 CTD PMID:27765674 PMID:29761207 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP bosentan results in increased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression ISO Bosentan results in decreased expression of ADH1C mRNA; Bosentan results in decreased expression of ADH1C protein CTD PMID:29761207 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression ISO Bosentan results in decreased expression of ADH4 mRNA; Bosentan results in decreased expression of ADH4 protein CTD PMID:29761207 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 affects expression ISO Bosentan affects the expression of ALDH8A1 mRNA CTD PMID:29761207 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385 		JBrowse link
G Aldob aldolase, fructose-bisphosphate B decreases expression ISO Bosentan results in decreased expression of ALDOB mRNA; Bosentan results in decreased expression of ALDOB protein CTD PMID:29761207 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 affects expression ISO Bosentan affects the expression of ASCL1 mRNA CTD PMID:29761207 NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO bosentan inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:17974986 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G C3h15orf48 similar to human chromosome 15 open reading frame 48 affects expression ISO Bosentan affects the expression of C15ORF48 mRNA CTD PMID:29761207 NCBI chr 3:109,719,952...109,723,505
Ensembl chr 3:109,719,897...109,724,006
Ensembl chr 3:109,719,897...109,724,006 		JBrowse link
G C9 complement C9 affects expression ISO Bosentan affects the expression of C9 mRNA CTD PMID:29761207 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Car12 carbonic anhydrase 12 affects expression ISO Bosentan affects the expression of CA12 mRNA CTD PMID:29761207 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Bosentan inhibits the reaction [Fluorouracil results in increased cleavage of CASP3 protein] CTD PMID:34800596 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases expression ISO Bosentan results in decreased expression of CAT mRNA CTD PMID:29761207 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO bosentan results in decreased expression of COL1A2 protein CTD PMID:11729239 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 decreases expression ISO Bosentan results in decreased expression of CPS1 mRNA; Bosentan results in decreased expression of CPS1 protein CTD PMID:29761207 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033 		JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule decreases expression
multiple interactions		 ISO bosentan results in decreased expression of CXADR mRNA; bosentan results in decreased expression of CXADR protein
EDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA]		 CTD PMID:20392896 NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Bosentan results in increased expression of CYP2B6 mRNA CTD PMID:18332078 PMID:29761207 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 affects expression ISO Bosentan affects the expression of CYP3A43 mRNA CTD PMID:29761207 NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Bosentan results in increased expression of CYP3A4 mRNA CTD PMID:18332078 PMID:29761207 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Bosentan results in decreased expression of CYP7A1 mRNA CTD PMID:29761207 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dclk1 doublecortin-like kinase 1 affects expression ISO Bosentan affects the expression of DCLK1 mRNA CTD PMID:29761207 NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956 		JBrowse link
G Dlx6 distal-less homeobox 6 decreases expression ISO bosentan results in decreased expression of DLX6 mRNA CTD PMID:15063187 NCBI chr 4:34,984,264...34,989,926
Ensembl chr 4:34,984,232...34,991,343 		JBrowse link
G Edn1 endothelin 1 decreases activity
multiple interactions
decreases expression		 EXP
ISO		 bosentan results in decreased activity of EDN1 protein
3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]; bosentan binds to and results in decreased activity of EDN1 protein; bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]; bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]
bosentan inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]; bosentan inhibits the reaction [Oxotremorine results in increased activity of EDN1 protein]; bosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein]; EDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA]
bosentan results in decreased expression of EDN1 protein		 CTD PMID:10474778 PMID:10961375 PMID:11093786 PMID:16431896 PMID:20392896 More... NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn3 endothelin 3 decreases activity EXP bosentan results in decreased activity of EDN3 protein CTD PMID:10961375 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093 		JBrowse link
G Ednra endothelin receptor type A multiple interactions ISO
EXP		 bosentan binds to and results in decreased activity of EDNRA protein
3,5-dibromosalicylic acid inhibits the reaction [bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]]; bosentan binds to and results in decreased activity of EDNRA protein; bosentan inhibits the reaction [EDN1 protein binds to EDNRA protein]		 CTD PMID:11093786 PMID:15964565 PMID:16219361 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO bosentan binds to and results in decreased activity of EDNRB protein CTD PMID:16219361 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Bosentan results in decreased expression of FABP1 mRNA; Bosentan results in decreased expression of FABP1 protein CTD PMID:29761207 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO bosentan inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; bosentan inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:12388107 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G G0s2 G0/G1switch 2 affects expression ISO Bosentan affects the expression of G0S2 mRNA CTD PMID:29761207 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 affects expression ISO Bosentan affects the expression of G6PC1 mRNA CTD PMID:29761207 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
affects activity		 ISO
EXP		 bosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 mRNA]; bosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]
bosentan affects the activity of GATA4 protein		 CTD PMID:17974986 PMID:21084678 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Bosentan results in increased expression of GCLC mRNA CTD PMID:29761207 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Bosentan inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of GPT protein] CTD PMID:33026618 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Bosentan results in decreased expression of GPX1 mRNA CTD PMID:29761207 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 decreases expression ISO Bosentan results in decreased expression of GSTT2 mRNA CTD PMID:29761207 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Bosentan results in increased expression of HMOX1 mRNA CTD PMID:29761207 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO Bosentan results in decreased expression of HNF4A mRNA CTD PMID:29761207 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 affects expression ISO Bosentan affects the expression of HSD3B1 mRNA CTD PMID:29761207 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Igf1 insulin-like growth factor 1 affects expression ISO Bosentan affects the expression of IGF1 mRNA CTD PMID:29761207 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il6 interleukin 6 increases expression ISO Bosentan results in increased expression of IL6 mRNA CTD PMID:29761207 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhbe inhibin subunit beta E affects expression ISO Bosentan affects the expression of INHBE mRNA CTD PMID:29761207 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172 		JBrowse link
G Kmo kynurenine 3-monooxygenase affects expression ISO Bosentan affects the expression of KMO mRNA CTD PMID:29761207 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
G Leap2 liver enriched antimicrobial peptide 2 affects expression ISO Bosentan affects the expression of LEAP2 mRNA CTD PMID:29761207 NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression ISO Bosentan results in decreased expression of MGST1 mRNA CTD PMID:29761207 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mrc1 mannose receptor, C type 1 affects expression ISO Bosentan affects the expression of MRC1 mRNA CTD PMID:29761207 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857 		JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression ISO Bosentan results in decreased expression of MTTP mRNA CTD PMID:29761207 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Bosentan inhibits the reaction [Fluorouracil results in increased expression of MYD88 protein] CTD PMID:34800596 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Bosentan inhibits the reaction [MYH7 gene mutant form results in increased expression of NPPB protein] CTD PMID:29741611 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfix nuclear factor I X decreases expression ISO Bosentan results in decreased expression of NFIX mRNA CTD PMID:29761207 NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Bosentan inhibits the reaction [Fluorouracil results in decreased expression of NOS3 protein] CTD PMID:34800596 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox4 NADPH oxidase 4 decreases expression ISO Bosentan results in decreased expression of NOX4 mRNA CTD PMID:29761207 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO Bosentan inhibits the reaction [MYH7 gene mutant form results in increased expression of NPPB protein] CTD PMID:29741611 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Bosentan results in increased expression of NQO1 mRNA CTD PMID:29761207 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 decreases expression ISO Bosentan results in decreased expression of NR1H2 mRNA CTD PMID:29761207 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression ISO Bosentan results in decreased expression of NR1H3 mRNA CTD PMID:29761207 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression ISO Bosentan results in decreased expression of NR1H4 mRNA CTD PMID:29761207 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression ISO Bosentan results in decreased expression of PCK2 mRNA CTD PMID:29761207 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 affects expression ISO Bosentan affects the expression of PGLYRP2 mRNA CTD PMID:29761207 NCBI chr 7:11,418,674...11,432,162
Ensembl chr 7:11,418,880...11,427,773 		JBrowse link
G Pklr pyruvate kinase L/R affects expression ISO Bosentan affects the expression of PKLR mRNA CTD PMID:29761207 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Pon1 paraoxonase 1 decreases expression ISO Bosentan results in decreased expression of PON1 mRNA CTD PMID:29761207 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Por cytochrome p450 oxidoreductase affects expression ISO Bosentan affects the expression of POR mRNA CTD PMID:29761207 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Bosentan results in decreased expression of PPARG mRNA CTD PMID:29761207 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO Bosentan results in decreased expression of PPARGC1A mRNA CTD PMID:29761207 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptgis prostaglandin I2 synthase multiple interactions EXP Bosentan inhibits the reaction [Monocrotaline increases expression of Ptgis mRNA in lung] RGD PMID:18612919 RGD:401901264 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 bosentan inhibits the reaction [Glucose results in increased activity of RELA protein]
Bosentan inhibits the reaction [Fluorouracil results in increased expression of RELA protein]		 CTD PMID:12388107 PMID:34800596 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions EXP Bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPA1 mRNA]; Bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPA1 mRNA]; Bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA] CTD PMID:15640287 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685 		JBrowse link
G Sftpb surfactant protein B multiple interactions EXP bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPB mRNA]; bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]; bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA] CTD PMID:15640287 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436 		JBrowse link
G Sftpc surfactant protein C multiple interactions EXP bosentan inhibits the reaction [Nitric Oxide Donors results in decreased expression of SFTPC mRNA]; bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]; bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA] CTD PMID:15640287 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP
ISO		 bosentan results in decreased expression of SLC10A1 mRNA
Bosentan results in decreased expression of SLC10A1 mRNA		 CTD PMID:27765674 PMID:28369585 PMID:29761207 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 affects expression ISO Bosentan affects the expression of SLC22A7 mRNA CTD PMID:29761207 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Bosentan results in increased expression of SLC3A2 mRNA; Bosentan results in increased expression of SLC3A2 protein CTD PMID:29761207 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc51a solute carrier family 51 member A increases expression ISO Bosentan results in increased expression of SLC51A mRNA CTD PMID:29761207 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Slc51b SLC51 subunit beta increases expression ISO Bosentan results in increased expression of SLC51B mRNA CTD PMID:29761207 NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 affects expression ISO Bosentan affects the expression of SLC6A1 mRNA CTD PMID:29761207 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 multiple interactions
increases uptake		 EXP [biochanin A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [kaempferol results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [licochalcone A results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [Luteolin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [sinensetin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan
SLCO1B1 protein results in increased uptake of Bosentan		 CTD PMID:32259555 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Bosentan results in decreased expression of SOD1 mRNA CTD PMID:29761207 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Bosentan results in increased expression of SOD2 mRNA CTD PMID:29761207 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 affects expression ISO Bosentan affects the expression of SULT1E1 mRNA CTD PMID:29761207 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Tat tyrosine aminotransferase affects expression ISO Bosentan affects the expression of TAT mRNA CTD PMID:29761207 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO bosentan inhibits the reaction [TGFB1 protein results in increased activity of EDN1 protein] CTD PMID:22796455 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Bosentan inhibits the reaction [Fluorouracil results in increased expression of TLR4 protein] CTD PMID:34800596 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO bosentan inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:17974986 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni1 troponin I1, slow skeletal type multiple interactions EXP Bosentan inhibits the reaction [Fluorouracil results in increased expression of TNNI1 protein] CTD PMID:34800596 NCBI chr13:47,229,217...47,241,640
Ensembl chr13:47,229,216...47,241,644 		JBrowse link
G Txn2 thioredoxin 2 decreases expression ISO Bosentan results in decreased expression of TXN2 mRNA CTD PMID:29761207 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Bosentan results in increased expression of TXNRD1 mRNA CTD PMID:29761207 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression ISO Bosentan results in decreased expression of UGT1A6 mRNA CTD PMID:29761207 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vnn1 vanin 1 affects expression ISO Bosentan affects the expression of VNN1 mRNA CTD PMID:29761207 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395 		JBrowse link
G Xdh xanthine dehydrogenase decreases expression ISO Bosentan results in decreased expression of XDH mRNA CTD PMID:29761207 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            cardiovascular drug 8644
              antihypertensive agent 1946
                bosentan 95
                  bosentan hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      chalcogen 19569
                        oxygen atom 19541
                          oxygen molecular entity 19541
                            hydroxides 19347
                              oxoacid 18782
                                chalcogen oxoacid 13784
                                  sulfur oxoacid 13573
                                    sulfonic acid 11618
                                      sulfonic acid derivative 11618
                                        sulfonamide 5307
                                          bosentan 95
                                            bosentan hydrate 0
paths to the root