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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fomepizole
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Accession:CHEBI:5141 term browser browse the term
Definition:A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Synonyms:exact_synonym: 4-methyl-1H-pyrazole
 related_synonym: 4-Methylpyrazol;   4-Methylpyrazole;   Antizol;   Formula=C4H6N2;   InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6);   InChIKey=RIKMMFOAQPJVMX-UHFFFAOYSA-N;   SMILES=Cc1cn[nH]c1;   fomepizol;   fomepizolum
 xref: CAS:7554-65-6;   DrugBank:DB01213;   Drug_Central:1233;   HMDB:HMDB0015344;   KEGG:C07837;   KEGG:D00707;   LINCS:LSM-5671
 xref_mesh: MESH:C010238
 xref: PDBeChem:4PZ;   PMID:11172179;   PMID:11899949;   PMID:16035197;   PMID:22554311;   Reaxys:105204;   Wikipedia:Fomepizole


show annotations for term's descendants           Sort by:
fomepizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide decreases activity
multiple interactions 		ISO fomepizole results in decreased activity of ADH1 protein
fomepizole inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol] 		CTD PMID:7943667 PMID:21167143 NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide multiple interactions ISO fomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol] CTD PMID:21167143 NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:229,622,095...229,641,879 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO fomepizole inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol] CTD PMID:21167143 NCBI chr 2:229,422,125...229,436,584
Ensembl chr 2:229,421,252...229,436,691 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein] CTD PMID:29739258 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen affects the localization of BAX protein] CTD PMID:29739258 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen results in increased cleavage of CASP12 protein] CTD PMID:38042273 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 mRNA]; Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 protein] CTD PMID:19280452 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA] CTD PMID:9540844 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of CXCL2 mRNA] CTD PMID:20116195 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
increases activity
decreases activity 		ISO
EXP 		[Fomepizole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of vinyl fluoride; Fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]; Fomepizole inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; Fomepizole inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]; Fomepizole inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]; Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]
fomepizole results in increased expression of CYP2E1 protein
[fomepizole results in decreased activity of CYP2E1 protein] which results in decreased uptake of vinyl fluoride; fomepizole promotes the reaction [CYP2E1 protein results in increased metabolism of methylformamide]
fomepizole results in increased activity of CYP2E1 protein 		CTD PMID:1538706 PMID:3113478 PMID:3782137 PMID:8074729 PMID:8531136 More... NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases expression 		EXP fomepizole promotes the reaction [Ethanol results in increased expression of CYP4A1 protein]
fomepizole results in increased expression of CYP4A1 protein 		CTD PMID:20116195 NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen results in increased expression of DDIT3 protein] CTD PMID:38042273 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen affects the localization of DIABLO protein] CTD PMID:29739258 NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO 		fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]]
Fomepizole inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; Fomepizole inhibits the reaction [leupeptin promotes the reaction [Acetaminophen results in increased activity of GPT protein]] 		CTD PMID:11394713 PMID:29739258 PMID:33458793 PMID:38042273 PMID:38551724 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] CTD PMID:28300663 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA] CTD PMID:16737972 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression 		EXP Ethanol inhibits the reaction [fomepizole results in decreased expression of IL4 mRNA]; fomepizole inhibits the reaction [Ethanol results in decreased expression of IL4 mRNA] CTD PMID:20116195 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen results in increased expression of LCN2 protein] CTD PMID:38042273 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen results in decreased activity of LDHA protein] CTD PMID:38042273 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased lipidation of MAP1LC3B protein] CTD PMID:24492484 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK1 protein] CTD PMID:18317950 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK3 protein] CTD PMID:18317950 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects binding
multiple interactions 		ISO Fomepizole binds to MAPK8 protein
Fomepizole inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein] 		CTD PMID:29739258 PMID:30903181 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 affects binding ISO Fomepizole binds to MAPK9 protein CTD PMID:30903181 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA] CTD PMID:17934066 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of PDGFRB mRNA] CTD PMID:20116195 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233 		JBrowse link
G Pdyn prodynorphin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA] CTD PMID:17934066 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503 		JBrowse link
G Penk proenkephalin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of PENK mRNA] CTD PMID:17934066 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705 		JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA] CTD PMID:17934066 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in decreased activity of PPARA protein] CTD PMID:11022051 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fomepizole inhibits the reaction [Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]] CTD PMID:17030193 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP fomepizole inhibits the reaction [allyl alcohol affects the localization of PRKCD protein] CTD PMID:12755590 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of TNF mRNA] CTD PMID:20116195 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of TRIB3 mRNA] CTD PMID:20116195 NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802 		JBrowse link
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  CHEBI ontology 20849
    role 20820
      application 20622
        pharmaceutical 20416
          drug 20416
            protective agent 18637
              fomepizole 35
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  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20403
                                organic heterocyclic compound 19386
                                  heteroarene 17452
                                    monocyclic heteroarene 15192
                                      azole 14611
                                        diazole 10862
                                          pyrazoles 2366
                                            pyrazole 1616
                                              1H-pyrazole 1615
                                                fomepizole 35
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