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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fluticasone
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Accession:CHEBI:5134 term browser browse the term
Definition:A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.
Synonyms:related_synonym: S-(fluoromethyl) (6alpha,11beta,16alpha,17alpha)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioate;   fluticasona;   fluticasonum
 xref: CAS:90566-53-3
 xref_mesh: MESH:C065382
 xref: Reaxys:8173308;   kegg.compound:C07815;   kegg.drug:D07981;   pubmed:22370858;   pubmed:23276699;   pubmed:23591272;   pubmed:23796052;   wikipedia.en:Fluticasone
 chemrof_formula: C22H27F3O4S
 chemrof_inchi: InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
 chemrof_inchikey: MGNNYOODZCAHBA-GQKYHHCASA-N
 chemrof_smiles: [H][C@@]12C[C@@H](C)[C@](O)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@@]21C
 cyclic_relationship: has_parent_hybride CHEBI:35509


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fluticasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases secretion
multiple interactions
increases expression 		ISO ABCB1 protein results in increased secretion of Fluticasone
Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Fluticasone]
Fluticasone results in increased expression of ABCB1 protein 		CTD PMID:22464980 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Anxa1 annexin A1 affects localization ISO Fluticasone affects the localization of ANXA1 protein CTD PMID:15753895 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831 		JBrowse link
G Ar androgen receptor multiple interactions ISO Fluticasone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Fluticasone results in increased expression of BGLAP protein CTD PMID:11555383 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP3 protein CTD PMID:15536434 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP8 protein CTD PMID:15536434 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Fluticasone inhibits the reaction [RELA protein binds to CCL11 promoter]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]] CTD PMID:15531761 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:15531761 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein] CTD PMID:9150321 PMID:10903220 PMID:14643170 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases activity
decreases secretion 		ISO Fluticasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Fluticasone results in increased activity of CSF2 protein
Fluticasone results in decreased secretion of CSF2 protein 		CTD PMID:10460758 PMID:10868704 PMID:11730731 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO Fluticasone inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]] CTD PMID:31822346 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Fluticasone inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]] CTD PMID:31822346 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Fluticasone results in decreased activity of CYP3A4 protein CTD PMID:20707410 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance
increases metabolic processing
decreases activity
increases expression
multiple interactions 		ISO CYP3A5 protein affects the susceptibility to Fluticasone
CYP3A5 protein results in increased metabolism of Fluticasone
Fluticasone results in decreased activity of CYP3A5 protein
Fluticasone results in increased expression of CYP3A5 mRNA
Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA] 		CTD PMID:20707410 PMID:24555085 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions
increases expression 		ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of DUSP1 mRNA; [Fluticasone co-treated with Tetradecanoylphorbol Acetate] results in increased expression of DUSP1 mRNA; Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of DUSP1 mRNA] CTD PMID:15860753 PMID:15862954 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644 		JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP Fluticasone inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:73,164,096...73,175,180
Ensembl chr10:73,164,096...73,175,180 		JBrowse link
G Ggt5 gamma-glutamyltransferase 5 multiple interactions
increases expression
increases activity 		ISO [Fluticasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4
Fluticasone results in increased expression of GGT5 mRNA 		CTD PMID:11447392 NCBI chr20:13,042,694...13,070,960
Ensembl chr20:13,042,696...13,070,892 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Fluticasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:9150321 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IFNG mRNA] CTD PMID:10075860 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Mifepristone inhibits the reaction [Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]] CTD PMID:9371735 PMID:10460758 PMID:31822346 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL2 mRNA] CTD PMID:10075860 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL4 mRNA] CTD PMID:10075860 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 decreases expression
multiple interactions 		ISO Fluticasone results in decreased expression of IL5 protein
Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL5 mRNA] 		CTD PMID:10075860 PMID:15634547 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of IL6 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]] CTD PMID:10075860 PMID:31822346 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Fluticasone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Fluticasone inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:25851902 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]] CTD PMID:31822346 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in decreased phosphorylation of NFKBIA protein CTD PMID:15536434 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Fluticasone results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects localization
affects binding 		ISO
EXP 		[Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of and results in increased activity of NR3C1 protein; [Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of NR3C1 protein; [Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein; Fluticasone affects the localization of and results in increased activity of NR3C1 protein; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]]; Salmeterol Xinafoate promotes the reaction [[Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of and results in increased activity of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of NR3C1 protein]
Fluticasone binds to NR3C1 protein 		CTD PMID:7878687 PMID:15531761 PMID:15536434 PMID:15860753 PMID:15862954 More... NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Fluticasone binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Pla2g4a phospholipase A2 group 4A affects localization ISO Fluticasone affects the localization of PLA2G4A protein CTD PMID:15753895 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Fluticasone results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Fluticasone promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]] CTD PMID:15531761 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO Fluticasone results in decreased expression of PRKCA protein CTD PMID:15634547 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]; Fluticasone inhibits the reaction [RELA protein binds to CCL11 promoter]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]] CTD PMID:15531761 PMID:31822346 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sele selectin E multiple interactions ISO Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE protein]; Mifepristone inhibits the reaction [Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]] CTD PMID:9371735 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Fluticasone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [Fluticasone results in decreased transport of Formoterol Fumarate] CTD PMID:17920670 PMID:21914487 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions
increases expression 		ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA; Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA] CTD PMID:15860753 PMID:15862954 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]] CTD PMID:31822346 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fluticasone inhibits the reaction [Amb a I protein, Ambrosia artemisiifolia results in increased expression of TNF mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Fluticasone inhibits the reaction [TNF protein results in increased acetylation of H4C16 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of SELE protein]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased expression of RELA protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]] CTD PMID:9150321 PMID:9371735 PMID:10075860 PMID:10100995 PMID:10903220 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases stability 		ISO Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Fluticasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Fluticasone results in decreased stability of VCAM1 mRNA 		CTD PMID:10100995 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        anti-asthmatic agent 9365
          anti-asthmatic drug 8710
            fluticasone 41
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Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbonyl compound 18827
                                    ketone 17484
                                      oxo steroid 9896
                                        3-oxo steroid 9875
                                          3-oxo-Delta(4) steroid 9083
                                            fluticasone 41
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