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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fluoxetine hydrochloride
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Accession:CHEBI:5119 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine hydrochloride. A selective serotonin reuptake inhibitor (SSRI), it is used for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Synonyms:related_synonym: (+-)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride;   (+-)-methyl-gamma-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride;   3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine hydrochloride;   Adofen;   Affectine;   Ansilan;   Deproxin;   Digassim;   Erocap;   Fluctin;   Fluctine;   Fludac;   Flufran;   Flunil;   Fluox-Puren;   Fluoxac;   Fluoxeren;   Fluoxil;   Flutin;   Flutine;   Fluxen;   Fluxil;   Fontex;   Foxetin;   LY 110140;   LY110140;   Lilly 110140;   Lorien;   Lovan;   Margrilan;   Modipran;   Neupax;   Nopres;   Nuzak;   Oxedep;   Pragmaten;   Prizma;   Proctin;   Prodep;   Profluzac;   Prozac;   Reconcile;   Rowexetina;   Sanzur;   Sarafem;   Selfemra;   Sinzac;   Zactin;   Zepax;   fluoxetine HCl;   rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride;   rac-fluoxetine hydrochloride
 xref: CAS:56296-78-7;   CAS:59333-67-4;   DrugBank:DB00472;   Reaxys:27994391;   Reaxys:6759273;   kegg.drug:D00823;   pmc:PMC3894728;   pubmed:16121130;   pubmed:19144769;   pubmed:23885544;   pubmed:24503458;   pubmed:24615023;   pubmed:24785765;   pubmed:25685415;   wikipedia.en:Fluoxetine
 chemrof_formula: C17H19ClF3NO


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fluoxetine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a4 solute carrier family 6 member 4 decreases expression EXP fluoxetine decreases expression of Slc6a4 mRNA in the dorsal raphe nucleus RGD PMID:15936043 RGD:38549581 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        pharmacological role 19772
          analgesic 14742
            fluoxetine hydrochloride 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      halogen 19174
                        chlorine atom 18936
                          chlorine molecular entity 18936
                            elemental chlorine 10248
                              monoatomic chlorine 10235
                                chloride 10235
                                  chloride salt 10235
                                    organic chloride salt 1119
                                      hydrochloride 749
                                        (R)-fluoxetine hydrochloride 1
                                          fluoxetine hydrochloride 1
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