CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: lucanthone
Accession: CHEBI:51052
browse the term
Definition: A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone.
Synonyms: exact_synonym: 1-{[2-(diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one
related_synonym: 1-diethylaminoethylethylamino-4-methyl-thioxanthenone; 1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-one; Formula=C20H24N2OS; InChI=1S/C20H24N2OS/c1-4-22(5-2)13-12-21-16-11-10-14(3)20-18(16)19(23)15-8-6-7-9-17(15)24-20/h6-11,21H,4-5,12-13H2,1-3H3; InChIKey=FBQPGGIHOFZRGH-UHFFFAOYSA-N; SMILES=CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12; lucanthonum; lucantona
alt_id: CHEBI:19039; CHEBI:6552
xref: Beilstein:312369; CAS:479-50-5; DrugBank:DB04967; Drug_Central:1616; HMDB:HMDB0015607; KEGG:C11715
xref_mesh: MESH:D008154
xref: PMID:21148553; PMID:21935361; PMID:4368942; PMID:6887199; PMID:9169823; Reaxys:312369; Wikipedia:Lucanthone
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Abca12
ATP binding cassette subfamily A member 12
increases expression
ISO
Lucanthone results in increased expression of ABCA12 mRNA
CTD
PMID:21148553
NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049
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Acta2
actin alpha 2, smooth muscle
increases expression
ISO
Lucanthone results in increased expression of ACTA2 mRNA
CTD
PMID:21148553
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Aldh1l2
aldehyde dehydrogenase 1 family, member L2
decreases expression
ISO
Lucanthone results in decreased expression of ALDH1L2 mRNA
CTD
PMID:21148553
NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776
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Anln
anillin, actin binding protein
decreases expression
ISO
Lucanthone results in decreased expression of ANLN mRNA
CTD
PMID:21148553
NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
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Anxa3
annexin A3
decreases expression
ISO
Lucanthone results in decreased expression of ANXA3 mRNA
CTD
PMID:21148553
NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
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Aqp3
aquaporin 3 (Gill blood group)
increases expression
ISO
Lucanthone results in increased expression of AQP3 mRNA
CTD
PMID:21148553
NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
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Arhgap11a
Rho GTPase activating protein 11A
decreases expression
ISO
Lucanthone results in decreased expression of ARHGAP11A mRNA
CTD
PMID:21148553
NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
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Asns
asparagine synthetase (glutamine-hydrolyzing)
decreases expression
ISO
Lucanthone results in decreased expression of ASNS mRNA
CTD
PMID:21148553
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Aspm
assembly factor for spindle microtubules
decreases expression
ISO
Lucanthone results in decreased expression of ASPM mRNA
CTD
PMID:21148553
NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
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Atad2
ATPase family, AAA domain containing 2
decreases expression
ISO
Lucanthone results in decreased expression of ATAD2 mRNA
CTD
PMID:21148553
NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
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Aurka
aurora kinase A
decreases expression
ISO
Lucanthone results in decreased expression of AURKA mRNA
CTD
PMID:21148553
NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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Aurkb
aurora kinase B
decreases expression
ISO
Lucanthone results in decreased expression of AURKB mRNA
CTD
PMID:21148553
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
Lucanthone results in decreased expression of BIRC5 mRNA
CTD
PMID:21148553
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Blm
BLM RecQ like helicase
decreases expression
ISO
Lucanthone results in decreased expression of BLM mRNA
CTD
PMID:21148553
NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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Brca1
BRCA1, DNA repair associated
decreases expression
ISO
Lucanthone results in decreased expression of BRCA1 mRNA
CTD
PMID:21148553
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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Brca2
BRCA2, DNA repair associated
decreases expression
ISO
Lucanthone results in decreased expression of BRCA2 mRNA
CTD
PMID:21148553
NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
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Bub1
BUB1 mitotic checkpoint serine/threonine kinase
decreases expression
ISO
Lucanthone results in decreased expression of BUB1 mRNA
CTD
PMID:21148553
NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
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Bub1b
BUB1 mitotic checkpoint serine/threonine kinase B
decreases expression
ISO
Lucanthone results in decreased expression of BUB1B mRNA
CTD
PMID:21148553
NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
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C2h5orf34
similar to human chromosome 5 open reading frame 34
decreases expression
ISO
Lucanthone results in decreased expression of C5ORF34 mRNA
CTD
PMID:21148553
NCBI chr 2:51,553,223...51,577,090
Ensembl chr 2:51,555,432...51,577,085
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Ccn3
cellular communication network factor 3
increases expression
ISO
Lucanthone results in increased expression of CCN3 mRNA
CTD
PMID:21148553
NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
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Ccna2
cyclin A2
decreases expression
ISO
Lucanthone results in decreased expression of CCNA2 mRNA
CTD
PMID:21148553
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
decreases expression
ISO
Lucanthone results in decreased expression of CCNB1 mRNA
CTD
PMID:21148553
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnb2
cyclin B2
decreases expression
ISO
Lucanthone results in decreased expression of CCNB2 mRNA
CTD
PMID:21148553
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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Cdc20
cell division cycle 20
decreases expression
ISO
Lucanthone results in decreased expression of CDC20 mRNA
CTD
PMID:21148553
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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Cdc25c
cell division cycle 25C
decreases expression
ISO
Lucanthone results in decreased expression of CDC25C mRNA
CTD
PMID:21148553
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdc45
cell division cycle 45
decreases expression
ISO
Lucanthone results in decreased expression of CDC45 mRNA
CTD
PMID:21148553
NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
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Cdc6
cell division cycle 6
decreases expression
ISO
Lucanthone results in decreased expression of CDC6 mRNA
CTD
PMID:21148553
NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
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Cdca2
cell division cycle associated 2
decreases expression
ISO
Lucanthone results in decreased expression of CDCA2 mRNA
CTD
PMID:21148553
NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
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Cdk1
cyclin-dependent kinase 1
decreases expression
ISO
Lucanthone results in decreased expression of CDK1 mRNA
CTD
PMID:21148553
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Lucanthone results in increased expression of CDKN1A mRNA
CTD
PMID:21148553
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn3
cyclin-dependent kinase inhibitor 3
decreases expression
ISO
Lucanthone results in decreased expression of CDKN3 mRNA
CTD
PMID:21148553
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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Cenpa
centromere protein A
decreases expression
ISO
Lucanthone results in decreased expression of CENPA mRNA
CTD
PMID:21148553
NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
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Cenpe
centromere protein E
decreases expression
ISO
Lucanthone results in decreased expression of CENPE mRNA
CTD
PMID:21148553
NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
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Cenpf
centromere protein F
decreases expression
ISO
Lucanthone results in decreased expression of CENPF mRNA
CTD
PMID:21148553
NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
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Cenpi
centromere protein I
decreases expression
ISO
Lucanthone results in decreased expression of CENPI mRNA
CTD
PMID:21148553
NCBI chr X:97,515,919...97,567,671
Ensembl chr X:97,515,972...97,567,657
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Cenpk
centromere protein K
decreases expression
ISO
Lucanthone results in decreased expression of CENPK mRNA
CTD
PMID:21148553
NCBI chr 2:35,360,390...35,421,372
Ensembl chr 2:35,360,132...35,385,706
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Cenpl
centromere protein L
decreases expression
ISO
Lucanthone results in decreased expression of CENPL mRNA
CTD
PMID:21148553
NCBI chr13:73,337,235...73,352,115
Ensembl chr13:73,337,257...73,352,114
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Cenpu
centromere protein U
decreases expression
ISO
Lucanthone results in decreased expression of CENPU mRNA
CTD
PMID:21148553
NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823
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Cep55
centrosomal protein 55
decreases expression
ISO
Lucanthone results in decreased expression of CEP55 mRNA
CTD
PMID:21148553
NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394
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Cip2a
cellular inhibitor of PP2A
decreases expression
ISO
Lucanthone results in decreased expression of CIP2A mRNA
CTD
PMID:21148553
NCBI chr11:51,792,143...51,823,016
Ensembl chr11:51,795,024...51,822,938
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Cit
citron rho-interacting serine/threonine kinase
decreases expression
ISO
Lucanthone results in decreased expression of CIT mRNA
CTD
PMID:21148553
NCBI chr12:40,603,073...40,764,846
Ensembl chr12:40,605,563...40,763,860
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Ckap2l
cytoskeleton associated protein 2-like
decreases expression
ISO
Lucanthone results in decreased expression of CKAP2L mRNA
CTD
PMID:21148553
NCBI chr 3:116,497,186...116,524,302
Ensembl chr 3:116,498,022...116,524,366
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Cks1b
CDC28 protein kinase regulatory subunit 1B
decreases expression
ISO
Lucanthone results in decreased expression of CKS1B mRNA
CTD
PMID:21148553
NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
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Clca2
chloride channel accessory 2
increases expression
ISO
Lucanthone results in increased expression of CLCA2 mRNA
CTD
PMID:21148553
NCBI chr 2:233,993,619...234,022,691
Ensembl chr 2:233,995,078...234,022,199
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Cldn1
claudin 1
decreases expression
ISO
Lucanthone results in decreased expression of CLDN1 mRNA
CTD
PMID:21148553
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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Clgn
calmegin
decreases expression
ISO
Lucanthone results in decreased expression of CLGN mRNA
CTD
PMID:21148553
NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758
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Cmklr2
chemerin chemokine-like receptor 2
decreases expression
ISO
Lucanthone results in decreased expression of CMKLR2 mRNA
CTD
PMID:21148553
NCBI chr 9:64,583,310...64,617,883
Ensembl chr 9:64,585,594...64,586,655
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Ctsd
cathepsin D
increases expression
ISO
Lucanthone results in increased expression of CTSD mRNA; Lucanthone results in increased expression of CTSD protein
CTD
PMID:21148553
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cxcl10
C-X-C motif chemokine ligand 10
increases expression
ISO
Lucanthone results in increased expression of CXCL10 mRNA
CTD
PMID:21148553
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
Lucanthone results in increased expression of CYP1A1 mRNA
CTD
PMID:21148553
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Ddit3
DNA-damage inducible transcript 3
decreases expression
ISO
Lucanthone results in decreased expression of DDIT3 mRNA
CTD
PMID:21148553
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Depdc1
DEP domain containing 1
decreases expression
ISO
Lucanthone results in decreased expression of DEPDC1 mRNA
CTD
PMID:21148553
NCBI chr 2:248,684,508...248,717,951
Ensembl chr 2:248,684,523...248,717,951
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Depdc1b
DEP domain containing 1B
decreases expression
ISO
Lucanthone results in decreased expression of DEPDC1B mRNA
CTD
PMID:21148553
NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779
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Dhcr24
24-dehydrocholesterol reductase
increases expression
ISO
Lucanthone results in increased expression of DHCR24 mRNA
CTD
PMID:21148553
NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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Diaph3
diaphanous-related formin 3
decreases expression
ISO
Lucanthone results in decreased expression of DIAPH3 mRNA
CTD
PMID:21148553
NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975
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Dlgap5
DLG associated protein 5
decreases expression
ISO
Lucanthone results in decreased expression of DLGAP5 mRNA
CTD
PMID:21148553
NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
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Dnai3
dynein axonemal intermediate chain 3
increases expression
ISO
Lucanthone results in increased expression of DNAI3 mRNA
CTD
PMID:21148553
NCBI chr 2:234,947,910...235,006,173
Ensembl chr 2:234,929,677...235,006,173
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Dpp4
dipeptidylpeptidase 4
increases expression
ISO
Lucanthone results in increased expression of DPP4 mRNA
CTD
PMID:21148553
NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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Dtl
denticleless E3 ubiquitin protein ligase homolog
decreases expression
ISO
Lucanthone results in decreased expression of DTL mRNA
CTD
PMID:21148553
NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
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Ect2
epithelial cell transforming 2
decreases expression
ISO
Lucanthone results in decreased expression of ECT2 mRNA
CTD
PMID:21148553
NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
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Efemp1
EGF containing fibulin extracellular matrix protein 1
decreases expression
ISO
Lucanthone results in decreased expression of EFEMP1 mRNA
CTD
PMID:21148553
NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018
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Ercc6l
ERCC excision repair 6 like, spindle assembly checkpoint helicase
decreases expression
ISO
Lucanthone results in decreased expression of ERCC6L mRNA
CTD
PMID:21148553
NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756
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Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
decreases expression
ISO
Lucanthone results in decreased expression of ESCO2 mRNA
CTD
PMID:21148553
NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306
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Espl1
extra spindle pole bodies like 1, separase
decreases expression
ISO
Lucanthone results in decreased expression of ESPL1 mRNA
CTD
PMID:21148553
NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984
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Exo1
exonuclease 1
decreases expression
ISO
Lucanthone results in decreased expression of EXO1 mRNA
CTD
PMID:21148553
NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
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Exosc8
exosome component 8
decreases expression
ISO
Lucanthone results in decreased expression of EXOSC8 mRNA
CTD
PMID:21148553
NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928
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Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
decreases expression
ISO
Lucanthone results in decreased expression of EZH2 mRNA
CTD
PMID:21148553
NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
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Fam72a
family with sequence similarity 72, member A
decreases expression
ISO
Lucanthone results in decreased expression of FAM72A mRNA
CTD
PMID:21148553
NCBI chr13:42,967,701...42,979,083
Ensembl chr13:42,967,578...42,984,208
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Fanci
FA complementation group I
decreases expression
ISO
Lucanthone results in decreased expression of FANCI mRNA
CTD
PMID:21148553
NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
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Fbxo5
F-box protein 5
decreases expression
ISO
Lucanthone results in decreased expression of FBXO5 mRNA
CTD
PMID:21148553
NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
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Flg
filaggrin
decreases expression
ISO
Lucanthone results in decreased expression of FLG mRNA
CTD
PMID:21148553
NCBI chr 2:178,884,793...178,912,986
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Foxm1
forkhead box M1
decreases expression
ISO
Lucanthone results in decreased expression of FOXM1 mRNA
CTD
PMID:21148553
NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
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Gbp1
guanylate binding protein 1
decreases expression
ISO
Lucanthone results in decreased expression of GBP1 mRNA
CTD
PMID:21148553
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
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Gdf15
growth differentiation factor 15
increases expression
ISO
Lucanthone results in increased expression of GDF15 mRNA
CTD
PMID:21148553
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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Gpnmb
glycoprotein nmb
increases expression
ISO
Lucanthone results in increased expression of GPNMB mRNA
CTD
PMID:21148553
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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Gpx8
glutathione peroxidase 8
decreases expression
ISO
Lucanthone results in decreased expression of GPX8 mRNA
CTD
PMID:21148553
NCBI chr 2:44,676,448...44,680,042
Ensembl chr 2:44,676,454...44,680,195
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Gtpbp2
GTP binding protein 2
decreases expression
ISO
Lucanthone results in decreased expression of GTPBP2 mRNA
CTD
PMID:21148553
NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241
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H1f4
H1.4 linker histone, cluster member
decreases expression
ISO
Lucanthone results in decreased expression of H1-4 mRNA
CTD
PMID:21148553
NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403
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H1f5
H1.5 linker histone, cluster member
decreases expression
ISO
Lucanthone results in decreased expression of H1-5 mRNA
CTD
PMID:21148553
NCBI chr17:42,726,132...42,727,162
Ensembl chr17:42,726,127...42,769,160
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H2ac12
H2A clustered histone 12
decreases expression
ISO
Lucanthone results in decreased expression of H2AC12 mRNA
CTD
PMID:21148553
NCBI chr17:42,486,415...42,486,880
Ensembl chr17:42,486,415...42,486,941
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H2ac21
H2A clustered histone 21
decreases expression
ISO
Lucanthone results in decreased expression of H2AC21 mRNA
CTD
PMID:21148553
NCBI chr 2:183,779,355...183,779,788
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H2ac4
H2A clustered histone 4
decreases expression
ISO
Lucanthone results in decreased expression of H2AC4 mRNA
CTD
PMID:21148553
NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381
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H2bc8
H2B clustered histone 8
decreases expression
ISO
Lucanthone results in decreased expression of H2BC8 mRNA
CTD
PMID:21148553
NCBI chr17:42,708,658...42,709,408
G
H2bc9
H2B clustered histone 9
decreases expression
ISO
Lucanthone results in decreased expression of H2BC9 mRNA
CTD
PMID:21148553
NCBI chr17:42,470,593...42,478,590
G
H3c13
H3 clustered histone 13
decreases expression
ISO
Lucanthone results in decreased expression of H3C13 mRNA
CTD
PMID:21148553
NCBI chr17:41,531,502...41,531,971
Ensembl chr 2:183,795,504...183,809,469 Ensembl chr17:183,795,504...183,809,469 Ensembl chr 2:183,795,504...183,809,469 Ensembl chr17:183,795,504...183,809,469 Ensembl chr17:183,795,504...183,809,469 Ensembl chr 2:183,795,504...183,809,469
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H4c14
H4 clustered histone 14
decreases expression
ISO
Lucanthone results in decreased expression of H4C2 mRNA
CTD
PMID:21148553
NCBI chr 2:183,831,601...183,831,996
Ensembl chr 2:183,825,994...183,832,048
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H4f3
H1.3 linker histone, cluster member
decreases expression
ISO
Lucanthone results in decreased expression of H1-3 mRNA
CTD
PMID:21148553
NCBI chr17:41,551,524...41,552,303
Ensembl chr17:41,529,667...41,552,334
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Hist1h2bq
histone cluster 1 H2B family member Q
decreases expression
ISO
Lucanthone results in decreased expression of H2BC7 mRNA
CTD
PMID:21148553
NCBI chr17:41,432,100...41,441,487
Ensembl chr17:41,429,164...41,442,153
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Hjurp
Holliday junction recognition protein
decreases expression
ISO
Lucanthone results in decreased expression of HJURP mRNA
CTD
PMID:21148553
NCBI chr 9:88,853,379...88,867,730
Ensembl chr 9:88,853,386...88,867,728
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Hmgb2
high mobility group box 2
decreases expression
ISO
Lucanthone results in decreased expression of HMGB2 mRNA
CTD
PMID:21148553
NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
Lucanthone results in increased expression of HMGCS1 mRNA
CTD
PMID:21148553
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Hmmr
hyaluronan-mediated motility receptor
decreases expression
ISO
Lucanthone results in decreased expression of HMMR mRNA
CTD
PMID:21148553
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
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Icam1
intercellular adhesion molecule 1
increases expression
ISO
Lucanthone results in increased expression of ICAM1 mRNA
CTD
PMID:21148553
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Idi1
isopentenyl-diphosphate delta isomerase 1
increases expression
ISO
Lucanthone results in increased expression of IDI1 mRNA
CTD
PMID:21148553
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Ifi30
IFI30, lysosomal thiol reductase
increases expression
ISO
Lucanthone results in increased expression of IFI30 mRNA
CTD
PMID:21148553
NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175
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Il18
interleukin 18
decreases expression
ISO
Lucanthone results in decreased expression of IL18 mRNA
CTD
PMID:21148553
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il24
interleukin 24
increases expression
ISO
Lucanthone results in increased expression of IL24 mRNA
CTD
PMID:21148553
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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Il6
interleukin 6
increases expression
ISO
Lucanthone results in increased expression of IL6 mRNA
CTD
PMID:21148553
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Iqgap3
IQ motif containing GTPase activating protein 3
decreases expression
ISO
Lucanthone results in decreased expression of IQGAP3 mRNA
CTD
PMID:21148553
NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956
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Itga3
integrin subunit alpha 3
increases expression
ISO
Lucanthone results in increased expression of ITGA3 mRNA
CTD
PMID:21148553
NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
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Kif11
kinesin family member 11
decreases expression
ISO
Lucanthone results in decreased expression of KIF11 mRNA
CTD
PMID:21148553
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
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Kif14
kinesin family member 14
decreases expression
ISO
Lucanthone results in decreased expression of KIF14 mRNA
CTD
PMID:21148553
NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164
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Kif15
kinesin family member 15
decreases expression
ISO
Lucanthone results in decreased expression of KIF15 mRNA
CTD
PMID:21148553
NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750
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Kif20a
kinesin family member 20A
decreases expression
ISO
Lucanthone results in decreased expression of KIF20A mRNA
CTD
PMID:21148553
NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
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Kif20b
kinesin family member 20B
decreases expression
ISO
Lucanthone results in decreased expression of KIF20B mRNA
CTD
PMID:21148553
NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
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Kif22
kinesin family member 22
decreases expression
ISO
Lucanthone results in decreased expression of KIF22 mRNA
CTD
PMID:21148553
NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401
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Kif23
kinesin family member 23
decreases expression
ISO
Lucanthone results in decreased expression of KIF23 mRNA
CTD
PMID:21148553
NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
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Kif2c
kinesin family member 2C
decreases expression
ISO
Lucanthone results in decreased expression of KIF2C mRNA
CTD
PMID:21148553
NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637
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Kif4a
kinesin family member 4A
decreases expression
ISO
Lucanthone results in decreased expression of KIF4A mRNA
CTD
PMID:21148553
NCBI chr X:65,721,746...65,824,277
Ensembl chr X:65,721,779...65,824,139
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Kifc1
kinesin family member C1
decreases expression
ISO
Lucanthone results in decreased expression of KIFC1 mRNA
CTD
PMID:21148553
NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
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Knl1
kinetochore scaffold 1
decreases expression
ISO
Lucanthone results in decreased expression of KNL1 mRNA
CTD
PMID:21148553
NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
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Lamp3
lysosomal-associated membrane protein 3
decreases expression
ISO
Lucanthone results in decreased expression of LAMP3 mRNA
CTD
PMID:21148553
NCBI chr11:81,153,491...81,224,643
Ensembl chr11:81,193,649...81,221,784
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Lin9
lin-9 DREAM MuvB core complex component
decreases expression
ISO
Lucanthone results in decreased expression of LIN9 mRNA
CTD
PMID:21148553
NCBI chr13:92,374,612...92,419,664
Ensembl chr13:92,374,593...92,419,654
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Lrp1
LDL receptor related protein 1
increases expression
ISO
Lucanthone results in increased expression of LRP1 mRNA
CTD
PMID:21148553
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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Lxn
latexin
increases expression
ISO
Lucanthone results in increased expression of LXN mRNA
CTD
PMID:21148553
NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460
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Mad2l1
mitotic arrest deficient 2 like 1
decreases expression
ISO
Lucanthone results in decreased expression of MAD2L1 mRNA
CTD
PMID:21148553
NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
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Mboat1
membrane bound O-acyltransferase domain containing 1
decreases expression
ISO
Lucanthone results in decreased expression of MBOAT1 mRNA
CTD
PMID:21148553
NCBI chr17:34,331,413...34,445,088
Ensembl chr17:34,331,422...34,445,088
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Mcm10
minichromosome maintenance 10 replication initiation factor
decreases expression
ISO
Lucanthone results in decreased expression of MCM10 mRNA
CTD
PMID:21148553
NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
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Mcm8
minichromosome maintenance 8 homologous recombination repair factor
decreases expression
ISO
Lucanthone results in decreased expression of MCM8 mRNA
CTD
PMID:21148553
NCBI chr 3:120,086,741...120,117,008
Ensembl chr 3:120,086,763...120,117,008
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Melk
maternal embryonic leucine zipper kinase
decreases expression
ISO
Lucanthone results in decreased expression of MELK mRNA
CTD
PMID:21148553
NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Lucanthone results in decreased expression of MKI67 mRNA
CTD
PMID:21148553
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mmp1
matrix metallopeptidase 1
increases expression
ISO
Lucanthone results in increased expression of MMP1 mRNA
CTD
PMID:21148553
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mnd1
meiotic nuclear divisions 1
decreases expression
ISO
Lucanthone results in decreased expression of MND1 mRNA
CTD
PMID:21148553
NCBI chr 2:169,433,523...169,496,081
Ensembl chr 2:169,433,540...169,496,096
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Mocos
molybdenum cofactor sulfurase
decreases expression
ISO
Lucanthone results in decreased expression of MOCOS mRNA
CTD
PMID:21148553
NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187
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Msmo1
methylsterol monooxygenase 1
increases expression
ISO
Lucanthone results in increased expression of MSMO1 mRNA
CTD
PMID:21148553
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Mtfr2
mitochondrial fission regulator 2
decreases expression
ISO
Lucanthone results in decreased expression of MTFR2 mRNA
CTD
PMID:21148553
NCBI chr 1:15,123,232...15,138,632
Ensembl chr 1:15,070,894...15,148,832
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Mx1
MX dynamin like GTPase 1
increases expression
ISO
Lucanthone results in increased expression of MX1 mRNA
CTD
PMID:21148553
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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Mybl2
MYB proto-oncogene like 2
decreases expression
ISO
Lucanthone results in decreased expression of MYBL2 mRNA
CTD
PMID:21148553
NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
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Ncapg
non-SMC condensin I complex, subunit G
decreases expression
ISO
Lucanthone results in decreased expression of NCAPG mRNA
CTD
PMID:21148553
NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902
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Ncapg2
non-SMC condensin II complex, subunit G2
decreases expression
ISO
Lucanthone results in decreased expression of NCAPG2 mRNA
CTD
PMID:21148553
NCBI chr 6:137,342,449...137,418,083
Ensembl chr 6:137,342,943...137,415,159
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Ncaph
non-SMC condensin I complex, subunit H
decreases expression
ISO
Lucanthone results in decreased expression of NCAPH mRNA
CTD
PMID:21148553
NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180
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Ndc80
NDC80 kinetochore complex component
decreases expression
ISO
Lucanthone results in decreased expression of NDC80 mRNA
CTD
PMID:21148553
NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
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Nek2
NIMA-related kinase 2
decreases expression
ISO
Lucanthone results in decreased expression of NEK2 mRNA
CTD
PMID:21148553
NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
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Nemp1
nuclear envelope integral membrane protein 1
decreases expression
ISO
Lucanthone results in decreased expression of NEMP1 mRNA
CTD
PMID:21148553
NCBI chr 7:63,514,025...63,538,791
Ensembl chr 7:63,479,951...63,534,602
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Niban1
niban apoptosis regulator 1
decreases expression
ISO
Lucanthone results in decreased expression of NIBAN1 mRNA
CTD
PMID:21148553
NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
increases expression
ISO
Lucanthone results in increased expression of NR4A2 mRNA
CTD
PMID:21148553
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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Nuf2
NUF2 component of NDC80 kinetochore complex
decreases expression
ISO
Lucanthone results in decreased expression of NUF2 mRNA
CTD
PMID:21148553
NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
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Nusap1
nucleolar and spindle associated protein 1
decreases expression
ISO
Lucanthone results in decreased expression of NUSAP1 mRNA
CTD
PMID:21148553
NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
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Orc6
origin recognition complex, subunit 6
decreases expression
ISO
Lucanthone results in decreased expression of ORC6 mRNA
CTD
PMID:21148553
NCBI chr19:21,757,867...21,765,638
Ensembl chr19:21,757,866...21,765,662
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Otub2
OTU deubiquitinase, ubiquitin aldehyde binding 2
increases expression
ISO
Lucanthone results in increased expression of OTUB2 mRNA
CTD
PMID:21148553
NCBI chr 6:122,545,067...122,563,657
Ensembl chr 6:122,545,061...122,563,644
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Pbk
PDZ binding kinase
decreases expression
ISO
Lucanthone results in decreased expression of PBK mRNA
CTD
PMID:21148553
NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
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Pclaf
PCNA clamp associated factor
decreases expression
ISO
Lucanthone results in decreased expression of PCLAF mRNA
CTD
PMID:21148553
NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994 Ensembl chr 8:66,420,587...66,432,994
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Phgdh
phosphoglycerate dehydrogenase
decreases expression
ISO
Lucanthone results in decreased expression of PHGDH mRNA
CTD
PMID:21148553
NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
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Plk1
polo-like kinase 1
decreases expression
ISO
Lucanthone results in decreased expression of PLK1 mRNA
CTD
PMID:21148553
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
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Plk4
polo-like kinase 4
decreases expression
ISO
Lucanthone results in decreased expression of PLK4 mRNA
CTD
PMID:21148553
NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942
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Pole2
DNA polymerase epsilon 2, accessory subunit
decreases expression
ISO
Lucanthone results in decreased expression of POLE2 mRNA
CTD
PMID:21148553
NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305
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Prc1
protein regulator of cytokinesis 1
decreases expression
ISO
Lucanthone results in decreased expression of PRC1 mRNA
CTD
PMID:21148553
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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Prim1
DNA primase subunit 1
decreases expression
ISO
Lucanthone results in decreased expression of PRIM1 mRNA
CTD
PMID:21148553
NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526
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Prr11
proline rich 11
decreases expression
ISO
Lucanthone results in decreased expression of PRR11 mRNA
CTD
PMID:21148553
NCBI chr10:71,898,858...71,943,325
Ensembl chr10:71,901,202...71,921,012
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Psat1
phosphoserine aminotransferase 1
decreases expression
ISO
Lucanthone results in decreased expression of PSAT1 mRNA
CTD
PMID:21148553
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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Psmc3ip
PSMC3 interacting protein
decreases expression
ISO
Lucanthone results in decreased expression of PSMC3IP mRNA
CTD
PMID:21148553
NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423
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Ptchd4
patched domain containing 4
increases expression
ISO
Lucanthone results in increased expression of PTCHD4 mRNA
CTD
PMID:21148553
NCBI chr 9:18,462,934...18,666,272
Ensembl chr 9:18,463,737...18,665,705
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Pxdn
peroxidasin
increases expression
ISO
Lucanthone results in increased expression of PXDN mRNA
CTD
PMID:21148553
NCBI chr 6:46,580,749...46,658,345
Ensembl chr 6:46,580,761...46,658,345
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Racgap1
Rac GTPase-activating protein 1
decreases expression
ISO
Lucanthone results in decreased expression of RACGAP1 mRNA
CTD
PMID:21148553
NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831
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Rad51
RAD51 recombinase
decreases expression
ISO
Lucanthone results in decreased expression of RAD51 mRNA
CTD
PMID:21148553
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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Rad51ap1
RAD51 associated protein 1
decreases expression
ISO
Lucanthone results in decreased expression of RAD51AP1 mRNA
CTD
PMID:21148553
NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524
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Rrm2
ribonucleotide reductase regulatory subunit M2
decreases expression
ISO
Lucanthone results in decreased expression of RRM2 mRNA
CTD
PMID:21148553
NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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Sat1
spermidine/spermine N1-acetyl transferase 1
increases expression
ISO
Lucanthone results in increased expression of SAT1 mRNA
CTD
PMID:21148553
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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Scube1
signal peptide, CUB domain and EGF like domain containing 1
increases expression
ISO
Lucanthone results in increased expression of SCUBE1 mRNA
CTD
PMID:21148553
NCBI chr 7:114,759,016...114,880,995
Ensembl chr 7:114,759,010...114,880,940
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Sectm1b
secreted and transmembrane 1B
increases expression
ISO
Lucanthone results in increased expression of SECTM1 mRNA
CTD
PMID:21148553
NCBI chr10:106,324,070...106,333,779
Ensembl chr10:106,325,203...106,333,769
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Serpinb2
serpin family B member 2
increases expression
ISO
Lucanthone results in increased expression of SERPINB2 mRNA
CTD
PMID:21148553
NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
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Sgo1
shugoshin 1
decreases expression
ISO
Lucanthone results in decreased expression of SGO1 mRNA
CTD
PMID:21148553
NCBI chr 9:6,672,109...6,687,908
Ensembl chr 9:6,672,123...6,687,805
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Sgo2
shugoshin 2
decreases expression
ISO
Lucanthone results in decreased expression of SGO2 mRNA
CTD
PMID:21148553
NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229
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Shc4
SHC adaptor protein 4
increases expression
ISO
Lucanthone results in increased expression of SHC4 mRNA
CTD
PMID:21148553
NCBI chr 3:112,880,598...112,974,216
Ensembl chr 3:112,880,600...112,974,366
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Shcbp1
SHC binding and spindle associated 1
decreases expression
ISO
Lucanthone results in decreased expression of SHCBP1 mRNA
CTD
PMID:21148553
NCBI chr16:84,672,277...84,703,843
Ensembl chr16:84,672,321...84,703,844
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Slc1a4
solute carrier family 1 member 4
decreases expression
ISO
Lucanthone results in decreased expression of SLC1A4 mRNA
CTD
PMID:21148553
NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
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Smc4
structural maintenance of chromosomes 4
decreases expression
ISO
Lucanthone results in decreased expression of SMC4 mRNA
CTD
PMID:21148553
NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
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Spag5
sperm associated antigen 5
decreases expression
ISO
Lucanthone results in decreased expression of SPAG5 mRNA
CTD
PMID:21148553
NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745
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Spata18
spermatogenesis associated 18
increases expression
ISO
Lucanthone results in increased expression of SPATA18 mRNA
CTD
PMID:21148553
NCBI chr14:34,531,931...34,558,671
Ensembl chr14:34,531,061...34,558,687
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Spc25
SPC25 component of NDC80 kinetochore complex
decreases expression
ISO
Lucanthone results in decreased expression of SPC25 mRNA
CTD
PMID:21148553
NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959
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Spdl1
spindle apparatus coiled-coil protein 1
decreases expression
ISO
Lucanthone results in decreased expression of SPDL1 mRNA
CTD
PMID:21148553
NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127
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Stmn1
stathmin 1
decreases expression
ISO
Lucanthone results in decreased expression of STMN1 mRNA
CTD
PMID:21148553
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
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Sulf2
sulfatase 2
increases expression
ISO
Lucanthone results in increased expression of SULF2 mRNA
CTD
PMID:21148553
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
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Tcp11l2
t-complex 11 like 2
increases expression
ISO
Lucanthone results in increased expression of TCP11L2 mRNA
CTD
PMID:21148553
NCBI chr 7:19,150,241...19,185,135
Ensembl chr 7:19,150,252...19,185,095
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Tfpi2
tissue factor pathway inhibitor 2
increases expression
ISO
Lucanthone results in increased expression of TFPI2 mRNA
CTD
PMID:21148553
NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
ISO
Lucanthone results in increased expression of TIPARP mRNA
CTD
PMID:21148553
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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Tmem45a
transmembrane protein 45A
increases expression
ISO
Lucanthone results in increased expression of TMEM45A mRNA
CTD
PMID:21148553
NCBI chr11:43,713,309...43,799,526
Ensembl chr11:43,713,782...43,799,526
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Tnfsf15
TNF superfamily member 15
increases expression
ISO
Lucanthone results in increased expression of TNFSF15 mRNA
CTD
PMID:21148553
NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228
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Top2a
DNA topoisomerase II alpha
decreases expression
ISO
Lucanthone results in decreased expression of TOP2A mRNA
CTD
PMID:21148553
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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Tp53i3
tumor protein p53 inducible protein 3
increases expression
ISO
Lucanthone results in increased expression of TP53I3 mRNA
CTD
PMID:21148553
NCBI chr 6:27,818,327...27,825,753
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Tp53inp1
tumor protein p53 inducible nuclear protein 1
increases expression
ISO
Lucanthone results in increased expression of TP53INP1 mRNA
CTD
PMID:21148553
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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Tpx2
TPX2, microtubule nucleation factor
decreases expression
ISO
Lucanthone results in decreased expression of TPX2 mRNA
CTD
PMID:21148553
NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
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Ttk
Ttk protein kinase
decreases expression
ISO
Lucanthone results in decreased expression of TTK mRNA
CTD
PMID:21148553
NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
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Ube2t
ubiquitin-conjugating enzyme E2T
decreases expression
ISO
Lucanthone results in decreased expression of UBE2T mRNA
CTD
PMID:21148553
NCBI chr13:46,403,352...46,413,854
Ensembl chr13:46,403,375...46,414,835
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Wdr76
WD repeat domain 76
decreases expression
ISO
Lucanthone results in decreased expression of WDR76 mRNA
CTD
PMID:21148553
NCBI chr 3:108,456,784...108,491,528
Ensembl chr 3:108,456,815...108,490,840
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Xrcc2
X-ray repair cross complementing 2
decreases expression
ISO
Lucanthone results in decreased expression of XRCC2 mRNA
CTD
PMID:21148553
NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482
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Zwint
ZW10 interacting kinetochore protein
decreases expression
ISO
Lucanthone results in decreased expression of ZWINT mRNA
CTD
PMID:21148553
NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
Hycanthone results in increased activity of NR1I2 protein
CTD
PMID:25455453
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Tp53
tumor protein p53
affects activity
ISO
Hycanthone affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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