Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flucytosine
go back to main search page
Accession:CHEBI:5100 term browser browse the term
Definition:An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Synonyms:exact_synonym: 4-amino-5-fluoropyrimidin-2(1H)-one
 related_synonym: 5-FC;   5-Fluorocystosine;   5-Fluorocytosine;   Ancobon (TN);   Ancotil;   Formula=C4H4FN3O;   InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9);   InChIKey=XRECTZIEBJDKEO-UHFFFAOYSA-N;   SMILES=Nc1nc(=O)[nH]cc1F;   flucytosina;   flucytosinum
 xref: CAS:2022-85-7;   DrugBank:DB01099;   Drug_Central:1188;   HMDB:HMDB0015231;   KEGG:D00323;   LINCS:LSM-5878
 xref_mesh: MESH:D005437
 xref: PDBeChem:1LD;   PMID:11519290;   PMID:14871609;   PMID:18731030;   PMID:23576540;   PMID:25649231;   PMID:26201447;   PMID:28166217;   Patent:US2802005;   Patent:US2945038;   Patent:US3040026;   Wikipedia:Flucytosine


show annotations for term's descendants           Sort by:
flucytosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Flucytosine results in decreased expression of BCL2 protein CTD PMID:15592511 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression ISO Flucytosine results in increased expression of MDM2 protein CTD PMID:15592511 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Flucytosine results in increased expression of TP53 protein CTD PMID:15592511 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22327
    role 22313
      application 21950
        pro-agent 11520
          prodrug 11239
            flucytosine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 22327
    subatomic particle 22322
      composite particle 22322
        hadron 22322
          baryon 22322
            nucleon 22322
              atomic nucleus 22322
                atom 22322
                  main group element atom 22209
                    main group molecular entity 22209
                      s-block molecular entity 21837
                        hydrogen molecular entity 21756
                          hydrides 20799
                            inorganic hydride 18725
                              pnictogen hydride 18706
                                nitrogen hydride 18575
                                  azane 18480
                                    ammonia 18479
                                      organic amino compound 18479
                                        aromatic amine 15794
                                          aminopyrimidine 2049
                                            cytosine 1492
                                              flucytosine 3
paths to the root