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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flucytosine
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Accession:CHEBI:5100 term browser browse the term
Definition:An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.
Synonyms:related_synonym: 4-amino-5-fluoropyrimidin-2(1H)-one;   5-FC;   5-Fluorocystosine;   5-Fluorocytosine;   Ancobon (TN);   Ancotil;   flucytosina;   flucytosinum
 xref: CAS:2022-85-7;   DrugBank:DB01099;   HMDB:HMDB0015231
 xref_mesh: MESH:D005437
 xref: Patent:US2802005;   Patent:US2945038;   Patent:US3040026;   drugcentral:1188;   kegg.drug:D00323;   lincs.smallmolecule:LSM-5878;   pdb-ccd:1LD;   pubmed:11519290;   pubmed:14871609;   pubmed:18731030;   pubmed:23576540;   pubmed:25649231;   pubmed:26201447;   pubmed:28166217;   wikipedia.en:Flucytosine
 chemrof_formula: C4H4FN3O
 chemrof_inchi: InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
 chemrof_smiles: Nc1nc(=O)ncc1F
 chemrof_inchikey: XRECTZIEBJDKEO-UHFFFAOYSA-N
 cyclic_relationship: has_functional_parent CHEBI:16040


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flucytosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Flucytosine results in decreased expression of BCL2 protein CTD PMID:15592511 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Flucytosine results in increased expression of MDM2 protein CTD PMID:15592511 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Flucytosine results in increased expression of TP53 protein CTD PMID:15592511 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        pro-agent 8265
          prodrug 7985
            flucytosine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbohydrates and carbohydrate derivatives 15263
                                    carbohydrate derivative 14522
                                      glycosyl compound 13128
                                        N-glycosyl compound 5000
                                          nucleoside analogue 899
                                            flucytosine 3
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