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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doxycycline
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Accession:CHEBI:50845 term browser browse the term
Definition:Tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.
Synonyms:related_synonym: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE;   5-hydroxy-alpha-6-deoxytetracycline;   6alpha-deoxy-5-oxytetracycline;   Doxycyclin;   Formula=C22H24N2O8;   InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1;   InChIKey=JBIWCJUYHHGXTC-AKNGSSGZSA-N;   Jenacyclin;   SMILES=[H][C@@]12[C@@H](C)c3cccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]2O;   Supracyclin;   Vibramycin;   doxiciclina;   doxycycline (anhydrous);   doxycyclinum
 alt_id: CHEBI:42135;   CHEBI:4713
 xref: CAS:564-25-0;   Chemspider:10469369;   DrugBank:DB00254;   Drug_Central:961;   HMDB:HMDB0014399;   KEGG:C06973;   KEGG:D07876;   KNApSAcK:C00017127;   LIPID_MAPS_instance:LMPK07000001
 xref_mesh: MESH:D004318
 xref: MetaCyc:CPD-19256;   PDBeChem:DXT;   PMCID:PMC8464303;   PMCID:PMC8466018;   PMID:11477376;   PMID:11850258;   PMID:11891205;   PMID:1650428;   PMID:16651635;   PMID:19630297;   PMID:23698443;   PMID:24134630;   PMID:34128838;   PMID:34228348;   PMID:34318509;   PMID:34338231;   PMID:34355683;   PMID:34551605;   PMID:34577552;   Patent:US3019260;   Patent:US3200149;   Reaxys:3041790;   VSDB:1840;   Wikipedia:Doxycycline



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doxycycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Doxycycline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
increases expression
ISO Doxycycline results in decreased expression of ABCB1 protein
MB protein inhibits the reaction [Doxycycline results in increased expression of ABCB1 protein]
CTD PMID:11147995 PMID:38115220 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP Doxycycline results in decreased expression of ABCB4 mRNA CTD PMID:27765674 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions
ISO Doxycycline results in increased expression of ABCC1 protein
MB protein inhibits the reaction [Doxycycline results in increased expression of ABCC1 protein]
CTD PMID:38115220 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Doxycycline results in decreased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression EXP Doxycycline results in decreased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Doxycycline results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of ACTA2 mRNA] CTD PMID:18089841 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ada adenosine deaminase multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ADA mRNA] CTD PMID:18089841 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Agt angiotensinogen multiple interactions EXP Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP9 protein] CTD PMID:20837116 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO [[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA
[Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA; Doxycycline results in increased expression of AHR protein
CTD PMID:22273977 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ang angiogenin multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ANG mRNA] CTD PMID:18089841 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Arid3a AT-rich interaction domain 3A multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of ARID3A mRNA] CTD PMID:38115220 NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of ATF2 protein] CTD PMID:18089841 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAD protein] CTD PMID:17673183 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:17673183 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:17673183 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] CTD PMID:17673183 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Doxycycline increases expression of Bnip3 mRNA in cardiac myocytes RGD PMID:25489073 RGD:11561978 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Doxycycline inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein] CTD PMID:17673183 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CCNG2 mRNA] CTD PMID:18089841 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CDKN1A mRNA] CTD PMID:18089841 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of CEBPD mRNA] CTD PMID:38115220 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Chst4 carbohydrate sulfotransferase 4 multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of CHST4 mRNA] CTD PMID:38115220 NCBI chr19:37,993,471...38,002,123
Ensembl chr19:37,991,417...38,003,608
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 multiple interactions ISO [Doxycycline co-treated with erastin] results in increased expression of CITED2 mRNA CTD PMID:38115220 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]] CTD PMID:36565944 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]] CTD PMID:36565944 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO [[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA
[Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA
CTD PMID:22273977 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of DDIT4 mRNA] CTD PMID:18089841 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]] CTD PMID:36565944 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA] CTD PMID:18089841 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of GABARAPL1 mRNA] CTD PMID:38115220 NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
JBrowse link
G Gap43 growth associated protein 43 increases expression EXP Doxycycline results in increased expression of GAP43 protein CTD PMID:33798505 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]] CTD PMID:36565944 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of GEM mRNA] CTD PMID:18089841 NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of GJA1 mRNA] CTD PMID:18089841 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases expression
ISO MB protein promotes the reaction [Doxycycline results in decreased expression of GPX4 protein] CTD PMID:38115220 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Doxycycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmga2 high mobility group AT-hook 2 multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of HMGA2 mRNA] CTD PMID:38115220 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases response to substance
multiple interactions
ISO Doxycycline results in increased expression of HMOX1 protein
HMOX1 protein results in increased susceptibility to Doxycycline
Doxycycline promotes the reaction [erastin results in increased expression of HMOX1 mRNA]; ferrostatin-1 inhibits the reaction [HMOX1 protein results in increased susceptibility to Doxycycline]; MB protein promotes the reaction [Doxycycline results in increased expression of HMOX1 protein]
CTD PMID:38115220 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA] CTD PMID:17267227 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:25977597 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Krt5 keratin 5 multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of KRT5 mRNA] CTD PMID:38115220 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of LCN2 mRNA] CTD PMID:18089841 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K6 mRNA] CTD PMID:18089841 NCBI chr 5:145,440,126...145,452,213
Ensembl chr 5:145,440,346...145,452,212
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K8 mRNA] CTD PMID:18089841 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK14 protein] CTD PMID:18089841 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mb myoglobin increases response to substance
multiple interactions
increases expression
ISO MB protein results in increased susceptibility to Doxycycline
Doxycycline promotes the reaction [erastin results in increased expression of MB mRNA]; MB protein inhibits the reaction [Doxycycline results in increased expression of ABCB1 protein]; MB protein inhibits the reaction [Doxycycline results in increased expression of ABCC1 protein]; MB protein promotes the reaction [Doxycycline results in decreased expression of GPX4 protein]; MB protein promotes the reaction [Doxycycline results in increased expression of HMOX1 protein]
Doxycycline results in increased expression of MB protein
CTD PMID:38115220 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases expression
decreases activity
ISO Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Doxycycline results in increased expression of MMP13 mRNA
Doxycycline analog results in decreased activity of MMP13 protein
CTD PMID:17267227 PMID:20338993 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
ISO
EXP
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP2]
Doxycycline results in decreased activity of MMP2 protein
Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Lead results in increased expression of and results in increased activity of MMP2 protein]
Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]
Doxycycline results in decreased expression of MMP2 protein
Doxycycline analog results in decreased activity of MMP2 protein
CTD PMID:17267227 PMID:17498959 PMID:18089841 PMID:18178469 PMID:18836702 More... NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
decreases activity
ISO Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA]
Doxycycline results in decreased activity of MMP3 protein
CTD PMID:17267227 PMID:18089841 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO Doxycycline analog results in decreased activity of MMP8 protein CTD PMID:17267227 NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
decreases expression
ISO
EXP
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP9]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]
Doxycycline results in decreased activity of MMP9 protein
Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP9 protein]
Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
Doxycycline results in decreased expression of MMP9 protein
CTD PMID:15131573 PMID:17498959 PMID:18089841 PMID:18178469 PMID:19375915 More... NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MT2 mRNA] CTD PMID:18089841 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA] CTD PMID:18089841 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Nefh neurofilament heavy chain increases expression EXP Doxycycline results in increased expression of NEFH protein CTD PMID:33798505 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO Doxycycline results in decreased stability of and results in decreased expression of NOS2 mRNA
Doxycycline results in decreased expression of NOS2 protein
CTD PMID:16365451 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of NOX4 mRNA] CTD PMID:18089841 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]] CTD PMID:36565944 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 increases phosphorylation EXP Doxycycline results in increased phosphorylation of NTRK1 protein CTD PMID:33798505 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Osmr oncostatin M receptor multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of OSMR mRNA] CTD PMID:18089841 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
JBrowse link
G Pla2g7 phospholipase A2 group VII multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of PLA2G7 mRNA] CTD PMID:18089841 NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
JBrowse link
G Rnasel ribonuclease L multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of RNASEL mRNA] CTD PMID:38115220 NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704
JBrowse link
G Rnf38 ring finger protein 38 multiple interactions ISO [Doxycycline co-treated with erastin] results in increased expression of RNF38 mRNA CTD PMID:38115220 NCBI chr 5:58,358,771...58,467,424
Ensembl chr 5:58,361,976...58,467,446
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A8 mRNA] CTD PMID:18089841 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A9 mRNA] CTD PMID:18089841 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 mRNA]; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 protein] CTD PMID:18089841 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G Serpina3n serpin family A member 3N multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SERPINA3N mRNA] CTD PMID:18089841 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Doxycycline results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Doxycycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions ISO Doxycycline promotes the reaction [erastin results in increased expression of SLPI mRNA] CTD PMID:38115220 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Smyd1 SET and MYND domain containing 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of SMYD1 mRNA] CTD PMID:18089841 NCBI chr 4:103,195,330...103,252,989
Ensembl chr 4:103,200,322...103,311,766
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SOCS3 mRNA] CTD PMID:18089841 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of SOD1 protein] CTD PMID:17673183 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Syn1 synapsin I increases expression EXP Doxycycline results in increased expression of SYN1 protein CTD PMID:33798505 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions
decreases expression
ISO [Doxycycline analog results in decreased expression of TARDBP protein] inhibits the reaction [sodium arsenite affects the localization of TARDBP protein] CTD PMID:24019256 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TGFBR2 mRNA] CTD PMID:18089841 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Doxycycline inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:16134060 PMID:25977597 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TRP53INP1 mRNA] CTD PMID:18089841 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        immunomodulator 15067
          doxycycline 79
            doxycycline HCl + 0
            doxycycline monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            organic hydride 18687
                              organic fundamental parent 18687
                                hydrocarbon 18438
                                  cyclic hydrocarbon 17231
                                    arene 17212
                                      polycyclic arene 17037
                                        ortho-fused polycyclic arene 9836
                                          acene 7794
                                            tetracene 7791
                                              tetracyclines 526
                                                doxycycline 79
                                                  doxycycline HCl + 0
                                                  doxycycline monohydrate 0
paths to the root