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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:drospirenone
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Accession:CHEBI:50838 term browser browse the term
Definition:A steroid lactone that has formula C24H30O3.
Synonyms:exact_synonym: 3-oxo-6alpha,7alpha,15alpha,16alpha-tetrahydro-7'H,16'H-dicyclopropa[6,7;15,16]-17alpha-pregn-4-ene-21,17-carbolactone
 related_synonym: 1,2-Dihydrospirorenone;   6beta,7beta;15beta,16beta-Dimethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone;   Dehydrospirorenone;   Formula=C24H30O3;   InChI=1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1;   InChIKey=METQSPRSQINEEU-HXCATZOESA-N;   SMILES=[H][C@]12CC[C@@]3(C)[C@@]([H])([C@@H]4C[C@@H]4[C@@]33CCC(=O)O3)[C@]1([H])[C@H]1C[C@H]1C1=CC(=O)CC[C@]21C;   drospirenona;   drospirenonum
 xref: Beilstein:4765500;   CAS:67392-87-4;   DrugBank:DB01395;   Drug_Central:968;   KEGG:D03917
 xref_mesh: MESH:C035144
 xref: Patent:DE2652761;   Patent:US4129564;   Wikipedia:Drospirenone


show annotations for term's descendants           Sort by:
drospirenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO drospirenone results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ar androgen receptor multiple interactions
affects localization		 ISO drospirenone binds to and results in increased activity of AR protein
drospirenone affects the localization of AR protein		 CTD PMID:28478275 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in decreased activity of CYP17A1 protein CTD PMID:17418832 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions ISO drospirenone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:28257955 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of HSPD1 mRNA CTD PMID:19631796 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in decreased expression of NOS2 mRNA CTD PMID:19631796 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding EXP drospirenone binds to NR3C2 protein CTD PMID:1493716 PMID:14667981 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Pgr progesterone receptor affects binding ISO drospirenone binds to PGR protein CTD PMID:14667981 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Serpina6 serpin family A member 6 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SERPINA6 protein CTD PMID:11245553 NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349 		JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SHBG protein CTD PMID:11245553 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      group 19825
        organic group 18977
          3-oxo-Delta(4)-steroid group 9163
            3-oxo-Delta(4) steroid 9163
              drospirenone 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbonyl compound 18908
                                    ketone 17258
                                      oxo steroid 10532
                                        3-oxo steroid 9922
                                          3-oxo-Delta(4) steroid 9163
                                            drospirenone 10
paths to the root