Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
go back to main search page
Accession:CHEBI:50750 term browser browse the term
Definition:A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
Synonyms:related_synonym: DNA gyrase inhibitor;   DNA gyrase inhibitors;   DNA topoisomerase (ATP-hydrolysing) inhibitor;   DNA topoisomerase (ATP-hydrolysing) inhibitors;   DNA topoisomerase II inhibitor;   DNA topoisomerase II inhibitors;   EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors;   EC 5.99.1.3 inhibitor;   EC 5.99.1.3 inhibitors;   inhibitor of type II topoisomerase;   inhibitors of type II topoisomerase;   topoisomerase II inhibitor;   topoisomerase II inhibitors;   type II DNA topoisomerase inhibitor;   type II DNA topoisomerase inhibitors
 alt_id: CHEBI:132229;   CHEBI:50234



show annotations for term's descendants           Sort by:


Your selection has 4044 annotated objects. The maximum number of objects that can be shown is 2000. The list is too large to display.

  • Select a more specific term using the term browser
  • Download the entire list for this term
  • Display annotations for this term only (exclude descendants)



  • Term paths to the root
    Path 1
    Term Annotations click to browse term
      CHEBI ontology 19878
        role 19848
          biological role 19846
            biochemical role 19550
              enzyme inhibitor 18743
                EC 5.* (isomerase) inhibitor 7963
                  EC 5.99.* (other isomerases) inhibitor 7515
                    EC 5.99.1.* (miscellaneous isomerase) inhibitor 7515
                      topoisomerase inhibitor 7515
                        EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor 4044
                          (R)-temafloxacin + 0
                          (S)-temafloxacin + 0
                          4'-epidoxorubicin 64
                          4,4'-propane-1,3-diyldipiperazine-2,6-dione 0
                          ICRF-193 0
                          TOP-53 0
                          aclacinomycin A 12
                          aclacinomycin A zwitterion 0
                          amsacrine 42
                          betulinic acid + 55
                          celastrol 201
                          ciprofloxacin + 79
                          ciprofloxacin dihydrochloride 0
                          ciprofloxacin hydrochloride (anhydrous) + 0
                          ciprofloxacin hydrochloride hydrate 0
                          dextrofloxacin + 24
                          dihydrobetulinic acid 0
                          ellagic acid + 165
                          fisetin + 132
                          fleroxacin 1
                          flumequine 28
                          gatifloxacin + 8
                          genistein + 3613
                          kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-beta-D-apiofuranosyl-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          levofloxacin + 203
                          lucanthone + 189
                          maleimide + 85
                          manoalide 3
                          methyl brevifolincarboxylate 0
                          nepalensinol D 0
                          nepalensinol E 0
                          nepalensinol F 0
                          novobiocin 5
                          ofloxacin 24
                          procyanidin B4 + 0
                          temafloxacin 0
                          teniposide 23
                          wedelolactone 18
    paths to the root