Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:calcipotriol
go back to main search page
Accession:CHEBI:50749 term browser browse the term
Definition:A seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.
Synonyms:exact_synonym: (1S,3R,5Z,7E,22E,24S)-26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene-1,3,24-triol
 related_synonym: Calcipotriene;   Daivonex;   Dovonex;   Formula=C27H40O3;   InChI=1S/C27H40O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3/b13-6+,19-7+,21-10-/t17-,22-,23-,24+,25-,26+,27-/m1/s1;   InChIKey=LWQQLNNNIPYSNX-UROSTWAQSA-N;   SMILES=[C@@H]1(C[C@@H](C/C(/C1=C)=C/C=C\\2/[C@]3([C@](CCC2)([C@](CC3)([C@@H](/C=C/[C@@H](O)C4CC4)C)[H])C)[H])O)O
 alt_id: CHEBI:31335;   CHEBI:43947
 xref: CAS:112965-21-6;   DrugBank:DB02300;   Drug_Central:465;   HMDB:HMDB0015567;   KEGG:D01125;   LIPID_MAPS_instance:LMST03020106
 xref_mesh: MESH:C055085
 xref: PDBeChem:MC9;   PMID:23441902;   PMID:23621170;   PMID:24090798;   PMID:24286371;   PMID:24419155;   PMID:24533503;   PMID:24592364;   PMID:24593129;   PMID:24670691;   PMID:24788893;   PMID:24907534;   PMID:25027750;   PMID:25355140;   PMID:25484388;   PMID:25561873;   PMID:25574190;   PMID:25592908;   PMID:25904071;   PMID:26081515;   PMID:26224733;   PMID:7994616;   Patent:US4866048;   Patent:WO8700834;   Reaxys:5309193


show annotations for term's descendants           Sort by:
calcipotriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression		 ISO VDR protein affects the reaction [calcipotriene results in increased expression of ABCC3 protein] CTD PMID:30419252 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Becn1 beclin 1 increases expression ISO calcipotriene results in increased expression of BECN1 protein CTD PMID:21228817 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions ISO calcipotriene promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; calcipotriene promotes the reaction [resveratrol results in increased expression of CAMP mRNA] CTD PMID:24039193 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Crlf2 cytokine receptor-like factor 2 multiple interactions
increases expression		 ISO lithol rubine BCA analog promotes the reaction [calcipotriene results in increased expression of CRLF2 mRNA]; lithol rubine BCA promotes the reaction [calcipotriene results in increased expression of CRLF2 mRNA] CTD PMID:29462589 NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 increases expression ISO calcipotriene results in increased expression of CYP24A1 mRNA CTD PMID:7530193 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions		 ISO calcipotriene results in decreased expression of CYP7A1 protein
calcipotriene inhibits the reaction [VDR protein affects the expression of CYP7A1 protein]		 CTD PMID:30419252 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Flg filaggrin decreases expression ISO calcipotriene results in decreased expression of FLG protein CTD PMID:7508215 NCBI chr 2:178,884,793...178,912,986 JBrowse link
G Il13 interleukin 13 multiple interactions ISO [lithol rubine BCA analog results in increased susceptibility to calcipotriene] which results in increased expression of IL13 mRNA; [lithol rubine BCA results in increased susceptibility to calcipotriene] which results in increased expression of IL13 mRNA CTD PMID:29462589 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [lithol rubine BCA analog results in increased susceptibility to calcipotriene] which results in increased expression of IL4 mRNA; [lithol rubine BCA results in increased susceptibility to calcipotriene] which results in increased expression of IL4 mRNA CTD PMID:29462589 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO [lithol rubine BCA analog results in increased susceptibility to calcipotriene] which results in increased expression of IL5 mRNA; [lithol rubine BCA results in increased susceptibility to calcipotriene] which results in increased expression of IL5 mRNA CTD PMID:29462589 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Ivl involucrin decreases expression ISO calcipotriene results in decreased expression of IVL protein CTD PMID:7508215 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100 		JBrowse link
G Krt10 keratin 10 decreases expression ISO calcipotriene results in decreased expression of KRT10 protein CTD PMID:7508215 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701 		JBrowse link
G Krt16 keratin 16 decreases expression ISO calcipotriene results in decreased expression of KRT16 protein CTD PMID:7508215 NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt17 keratin 17 decreases expression ISO calcipotriene results in decreased expression of KRT17 protein CTD PMID:7508215 NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases response to substance ISO MAPK8 gene mutant form results in decreased susceptibility to calcipotriene CTD PMID:24046278 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO calcipotriene results in increased expression of NR0B2 protein CTD PMID:30419252 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO calcipotriene binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Tnfsf4 TNF superfamily member 4 multiple interactions ISO [lithol rubine BCA analog results in increased susceptibility to calcipotriene] which results in increased expression of TNFSF4 mRNA; [lithol rubine BCA results in increased susceptibility to calcipotriene] which results in increased expression of TNFSF4 mRNA CTD PMID:29462589 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
increases secretion
multiple interactions		 ISO calcipotriene results in increased expression of TSLP mRNA
calcipotriene results in increased secretion of TSLP protein
lithol rubine BCA analog promotes the reaction [calcipotriene results in increased expression of TSLP mRNA]; lithol rubine BCA analog promotes the reaction [calcipotriene results in increased secretion of TSLP protein]; lithol rubine BCA promotes the reaction [calcipotriene results in increased expression of TSLP mRNA]; lithol rubine BCA promotes the reaction [calcipotriene results in increased secretion of TSLP protein]
Calcipotriol increases expression of Tslp mRNA and protein in skin of external ear]		 CTD
RGD		 PMID:16880407 PMID:29462589 PMID:29310423 RGD:38549374 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
G Vdr vitamin D receptor multiple interactions
affects response to substance
increases expression		 ISO calcipotriene affects the reaction [Calcitriol binds to VDR protein]; calcipotriene inhibits the reaction [VDR protein affects the expression of CYP7A1 protein]; VDR protein affects the reaction [calcipotriene results in increased expression of ABCC3 protein]
VDR promoter SNP affects the susceptibility to calcipotriene
calcipotriene results in increased expression of VDR protein		 CTD PMID:7530193 PMID:15864137 PMID:30419252 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        pharmaceutical 19556
          drug 19556
            drug allergen 11848
              calcipotriol 20
                calcipotriol hydrate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic polycyclic compound 17311
                                  steroid 14705
                                    seco-steroid 2701
                                      seco-cholestane 2671
                                        calcipotriol 20
                                          calcipotriol hydrate + 0
paths to the root